Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture

Overview
TitlePlanarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture
AuthorsCebrià F, Newmark PA
TypeJournal Article
Journal NameDevelopment (Cambridge, England)
Volume132
Issue16
Year2005
Page(s)3691-703
CitationCebrià F, Newmark PA. Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture. Development (Cambridge, England). 2005 Aug; 132(16):3691-703.

Abstract

Conserved axon guidance mechanisms are essential for proper wiring of the nervous system during embryogenesis; however, the functions of these cues in adults and during regeneration remain poorly understood. Because freshwater planarians can regenerate a functional central nervous system (CNS) from almost any portion of their body, they are useful models in which to study the roles of guidance cues during neural regeneration. Here, we characterize two netrin homologs and one netrin receptor family member from Schmidtea mediterranea. RNAi analyses indicate that Smed-netR (netrin receptor) and Smed-netrin2 are required for proper CNS regeneration and that Smed-netR may mediate the response to Smed-netrin2. Remarkably, Smed-netR and Smed-netrin2 are also required in intact planarians to maintain the proper patterning of the CNS. These results suggest a crucial role for guidance cues, not only in CNS regeneration but also in maintenance of neural architecture.

Properties
Additional details for this publication include:
Property NameValue
Publication ModelPrint-Electronic
ISSN0950-1991
pISSN0950-1991
Publication Date2005 Aug
Journal AbbreviationDevelopment
LanguageEnglish
Language Abbreng
Publication TypeJournal Article
Journal CountryEngland
Publication TypeResearch Support, N.I.H., Extramural
Publication TypeResearch Support, Non-U.S. Gov't
Publication TypeResearch Support, U.S. Gov't, Non-P.H.S.
Publication TypeResearch Support, U.S. Gov't, P.H.S.
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DatabaseAccession
PMID: PMID:16033796