HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Overview


Name	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Smed ID	SMED30035968
Length (bp)	7780

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (SMED30035968) t-SNE clustered cells

Violin plots show distribution of expression levels for HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (SMED30035968) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (SMED30035968) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30035968

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
posterior side	SMED30035968	h1SMcG0014262	dd_Smed_v4_9316_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30035968	h1SMcG0014262	dd_Smed_v4_9316_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30035968	h1SMcG0014262	dd_Smed_v4_9316_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
Category 3 cell	SMED30035968	h1SMcG0014262	GAKN01015423.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
parenchyma	SMED30035968	h1SMcG0014262	GAKN01015423.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
parapharyngeal region	SMED30035968	h1SMcG0014262	DN303757	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
neoblast	SMED30035968	h1SMcG0014262	DN303757	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
parenchymal cell	SMED30035968	h1SMcG0014262	DN303757	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015

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Homology

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
Match: HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:HGNC Symbol;Acc:HGNC:4867])

HSP 1 Score: 605.134 bits (1559), Expect = 1.831e-174
Identity = 475/1677 (28.32%), Postives = 753/1677 (44.90%), Query Frame = 2

Query: 2321 LLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMEL---LAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVIL-TDQICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDK--LTCVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQF-SDT------------------------GDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCN-GDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNL------KNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQ-------------LHWLFTIDEVMKLTQAICFERDIPDNI-IPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            L+  P+ ++ Q L    + +L+     ++ +Y   + E +  +EL   LA   +S    S+ + W  Q L++    + ++          + D+  DL       I L      V   +    +  + T+  +GT+R+W++      + +L+QT +F           +R      E     ++P                ++ S +G YLA +L   +NIW       K  V      ++ L +P++        E+P +LLLV    G L L+ + D  S +    ++     +++VT  AW  E    A+GY +G ++L T +   K    L   H + +  + + P T H   T        E+++ +W        C+ SL  P  +  I W        K   ++  G  +GL+  W+   DT                            K +    GH+  V  +    +   L SG   G +N+WSL+D S++ T   G G +    W P+  +    +RS+          + L  N   +WA    +      A   + +  L      + F+  L  +L EQ+  E   V  G  +V+S Y+QCL      L+L                                         L  N  +PP+HQ               WL      +K  +A+      P++  +P    +  V  DE       SKW N         ++  W    PE W        Y+WG G  G+   +  +  +     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVT+ G L+ FG G  G+LG    S    P  V   +G  +IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  +D      + KV CG  FS ALT++G VYT+G    +G  L +      +      P     L G+  I D+  G + T AL +N  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA    P   R    S P      +P+    +Y  L   E + + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  +S  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ + LE++VCG   IS+++LK + RY + D    +  WFW  L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3326 LVTSPNFVVTQAL----VALLADKGAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTTLQTLADMGGDL--RKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTK---KQYSLQQTCVF-----------NRLEGDAEESLGSPSDP------------SFSPVSWSISGKYLAGALEKMVNIWQVNG--GKGLVDIQPHWVSALAWPEEGPATAWSGESP-ELLLVGRMDGSLGLIEVVDV-STMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDP-TGHILMT-----CAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSK----------DVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHL---------------------------------------DQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPD---LEPVPEDELVFLMDNSKWINGM-----DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQQIPVLAGV-IIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL--QLGLPDTVPPQYGALR--EVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIV--DLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDN 4853

HSP 2 Score: 181.8 bits (460), Expect = 1.367e-44
Identity = 124/371 (33.42%), Postives = 187/371 (50.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY-YPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L  + +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +++  +   ++ +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     I +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732

HSP 3 Score: 89.7373 bits (221), Expect = 1.007e-16
Identity = 85/319 (26.65%), Postives = 138/319 (43.26%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK   +     +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  +S G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGM-FIRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
Match: HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:4868])

HSP 1 Score: 357.836 bits (917), Expect = 1.457e-98
Identity = 297/1099 (27.02%), Postives = 480/1099 (43.68%), Query Frame = 2

Query: 3926 LKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIP--PQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            L   +  L + L  QF  E  +V+ G  +++S + + L+     L L    +P         +  +K  W         F+R  +   + +   L     L  LF +DEV K  + +  + +  D +                H        ++ +  +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD      S           +       IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ +P    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 1060 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLEL--DTLPC-------CAETHKWAW---------FRRYCMASRVAV--ALDKRTPLPRLF-LDEVAKKIRELMADSENMDVL----------------HE------SHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVVDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPM--------------------------FDLEG------SLDETGLGPS---------VGFDTLRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 2046

HSP 2 Score: 147.902 bits (372), Expect = 1.928e-34
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct:  209 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 570

HSP 3 Score: 93.2041 bits (230), Expect = 7.581e-18
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct:  364 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 573

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
Match: HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:4868])

HSP 1 Score: 357.836 bits (917), Expect = 4.673e-98
Identity = 270/947 (28.51%), Postives = 430/947 (45.41%), Query Frame = 2

Query: 4382 NNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIP--PQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            ++ +  +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD      S           +       IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ +P    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3922 HDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVVDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPM--------------------------FDLEG------SLDETGLGPS---------VGFDTLRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4799

HSP 2 Score: 149.443 bits (376), Expect = 7.450e-35
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2962 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3323

HSP 3 Score: 146.362 bits (368), Expect = 6.221e-34
Identity = 103/288 (35.76%), Postives = 151/288 (52.43%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A+   GEV+SWG G  G+LGHG    L++PK I A  GK +    +   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS ALT++G+VY+WG  D       +  +    E H+  P L   L G   +ID+ AG+    ALT +  ++ WGSN      + LR+     A  P L       H+  I+CG  ++ A +SC
Sbjct:  506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKLLEGLQG-KKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGL----DTKHIVGIACGPAQSFAWSSC 779

HSP 4 Score: 94.3597 bits (233), Expect = 3.923e-18
Identity = 68/231 (29.44%), Postives = 104/231 (45.02%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   Y WGCG  G  G        +P +++    +Q       I CGS  +  IT E +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK IE L+    +   CG   S  +T  G +Y +G G N +LG+        P+L++   G+ K+  V+ G  H LAL+ D +
Sbjct:  501 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK-KVIDVAAGSTHCLALTEDSE 729

HSP 5 Score: 94.3597 bits (233), Expect = 4.160e-18
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3117 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3326

HSP 6 Score: 60.4622 bits (145), Expect = 7.131e-8
Identity = 53/210 (25.24%), Postives = 94/210 (44.76%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            Y WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G    +    R  +       ++   +   V   +      IA+T  G+V+SWG G + +LGHG    ++ PK +E L+GK  I    G  H   +T    ++ +G     Q  + +      P  +   D +  +G ++CG   + A S+
Sbjct:  573 YTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG---DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVG-IACGPAQSFAWSS 778

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
Match: HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:4868])

HSP 1 Score: 219.935 bits (559), Expect = 1.793e-60
Identity = 129/365 (35.34%), Postives = 197/365 (53.97%), Query Frame = 2

Query: 6059 VFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-----FIPNPDPTIP--PQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ +P    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct:  132 VFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 488

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
Match: HECTD3 (HECT domain E3 ubiquitin protein ligase 3 [Source:HGNC Symbol;Acc:HGNC:26117])

HSP 1 Score: 142.895 bits (359), Expect = 7.530e-35
Identity = 99/343 (28.86%), Postives = 162/343 (47.23%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNEL-ENEAIFPRILTPIPSDTST-------------FIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSV---NKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISK---QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W+ K + EG  D GG + ++++++  EL  + A  P    P+P    T             ++PNP      +Y  ++G LM  A+R K+ + L L    WK+++   VS         S    LL + E    G D     +   K + F+    ++   E+   G    V   + S F+      RL E    +  ++     + P  +LD+++W+ LEK VCG   +++D L+ + R+ D + +D    +FWE L +F   ++S FLRFVTG+SRLP+       R++IY  K   +  ++LP+S TC + + LP Y S    E  LR A   C +ID D
Sbjct:  138 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTP---VPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKY-EWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVME----GMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPA-------RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 465

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 2.123e-23
Identity = 102/364 (28.02%), Postives = 161/364 (44.23%), Query Frame = 2

Query: 6047 KKEPVFIQTCRQVINMDAVS--LRLPWRAWK----VKLVNEGADDAGGAYDETISEICNEL--ENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNR-CIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            ++  V +Q  R  +  D+     RL    WK    +    E   DAGG   E  S I  E+   N A+F       P D  T++ N    I P+   YF F+G L+A ++   K +D +    F+K +    V   DL   DP++F SL  L  N    L  D L     V++F   SV     ++   G K +V+  N  ++V   C           ++     F  I P  ++ + + + LE ++ G  T+ ID +     Y           WFW  L SF + +K+ FL+FVTG S++P     S +     + F I++  +  + LP + TCFNQ+ LP+Y+S   +   L +AI +C
Sbjct: 3824 RRNDVSVQVSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALF----ITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLALD-LTFSTEVEEFGVRSVR----DLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIREC 4178

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 2.251e-23
Identity = 102/364 (28.02%), Postives = 161/364 (44.23%), Query Frame = 2

Query: 6047 KKEPVFIQTCRQVINMDAVS--LRLPWRAWK----VKLVNEGADDAGGAYDETISEICNEL--ENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNR-CIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            ++  V +Q  R  +  D+     RL    WK    +    E   DAGG   E  S I  E+   N A+F       P D  T++ N    I P+   YF F+G L+A ++   K +D +    F+K +    V   DL   DP++F SL  L  N    L  D L     V++F   SV     ++   G K +V+  N  ++V   C           ++     F  I P  ++ + + + LE ++ G  T+ ID +     Y           WFW  L SF + +K+ FL+FVTG S++P     S +     + F I++  +  + LP + TCFNQ+ LP+Y+S   +   L +AI +C
Sbjct: 3821 RRNDVSVQVSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALF----ITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLALD-LTFSTEVEEFGVRSVR----DLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIREC 4175

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 2.368e-23
Identity = 102/364 (28.02%), Postives = 161/364 (44.23%), Query Frame = 2

Query: 6047 KKEPVFIQTCRQVINMDAVS--LRLPWRAWK----VKLVNEGADDAGGAYDETISEICNEL--ENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNR-CIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            ++  V +Q  R  +  D+     RL    WK    +    E   DAGG   E  S I  E+   N A+F       P D  T++ N    I P+   YF F+G L+A ++   K +D +    F+K +    V   DL   DP++F SL  L  N    L  D L     V++F   SV     ++   G K +V+  N  ++V   C           ++     F  I P  ++ + + + LE ++ G  T+ ID +     Y           WFW  L SF + +K+ FL+FVTG S++P     S +     + F I++  +  + LP + TCFNQ+ LP+Y+S   +   L +AI +C
Sbjct: 3822 RRNDVSVQVSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALF----ITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLALD-LTFSTEVEEFGVRSVR----DLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIREC 4176

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 2.387e-23
Identity = 102/364 (28.02%), Postives = 161/364 (44.23%), Query Frame = 2

Query: 6047 KKEPVFIQTCRQVINMDAVS--LRLPWRAWK----VKLVNEGADDAGGAYDETISEICNEL--ENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNR-CIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            ++  V +Q  R  +  D+     RL    WK    +    E   DAGG   E  S I  E+   N A+F       P D  T++ N    I P+   YF F+G L+A ++   K +D +    F+K +    V   DL   DP++F SL  L  N    L  D L     V++F   SV     ++   G K +V+  N  ++V   C           ++     F  I P  ++ + + + LE ++ G  T+ ID +     Y           WFW  L SF + +K+ FL+FVTG S++P     S +     + F I++  +  + LP + TCFNQ+ LP+Y+S   +   L +AI +C
Sbjct: 3821 RRNDVSVQVSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALF----ITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLALD-LTFSTEVEEFGVRSVR----DLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIREC 4175

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 2.428e-23
Identity = 102/364 (28.02%), Postives = 161/364 (44.23%), Query Frame = 2

Query: 6047 KKEPVFIQTCRQVINMDAVS--LRLPWRAWK----VKLVNEGADDAGGAYDETISEICNEL--ENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNR-CIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            ++  V +Q  R  +  D+     RL    WK    +    E   DAGG   E  S I  E+   N A+F       P D  T++ N    I P+   YF F+G L+A ++   K +D +    F+K +    V   DL   DP++F SL  L  N    L  D L     V++F   SV     ++   G K +V+  N  ++V   C           ++     F  I P  ++ + + + LE ++ G  T+ ID +     Y           WFW  L SF + +K+ FL+FVTG S++P     S +     + F I++  +  + LP + TCFNQ+ LP+Y+S   +   L +AI +C
Sbjct: 3819 RRNDVSVQVSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALF----ITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLALD-LTFSTEVEEFGVRSVR----DLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIREC 4173

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
Match: HERC2 (gene:FBgn0031107 transcript:FBtr0301344)

HSP 1 Score: 330.102 bits (845), Expect = 6.371e-90
Identity = 264/941 (28.06%), Postives = 427/941 (45.38%), Query Frame = 2

Query: 4403 QQTELFQWYQDSPEYWISEY--SNSTYIWGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALS-TDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYD------MTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK---------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTP-----IPSDTSTFIPNP--DPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLL---SMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIY--ISKQPANS-LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDY 7102
               +L QW    P+ W   +  +++ Y WG   +G+ G         PT    +++    Q+  G      +T + KL A G G          +       +  L    +  V+ + G + H +A+T  GEV++WG G  GKLGHG+  +  +PK +E L G       CG  HSA +TASG +  +G G  G+LG+        P+LV+   G   I  ++CG      L  TD   ++++G+G YGKLG G       P  ++      ++KV CG  FS ALT++G VYTWG  DF    L    VD     H+  P   ++L G   II +  G+    A +++  +Y WG N    L  G       P LV   +  H+ +++CG  H  A   +  S R           + +P  PL         EY+         + ARLIL+ +++ELV       +P +             +SLG+                       K    +NI E           +   + I  +M+ ++ +  ++ ++RI  K               + VF Q  +++  +   +L LP R WKVK V E  DD GG Y E+I+E+C+EL+N ++   I TP       ++   F+ +P     +    F FLG+LM  A+RT  P+ ++L    W+++T  ++   DL  +D  Y   LL   +M++   L F +L+  +         V    T   H      +   N +++V   + +RLHEFD  ++ +R     + P+ +L + S   L+ +VCGS  I + +LK++A Y   D +  + +WFWE++  F   E+SLFLRFV G++RLP   +    R F+   + K P +  LP+S TCF  +++PRY  ++ +   L+ AI  C+SID D+Y
Sbjct: 4026 HDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGK-HCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAID-IACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDF--HRLGHGSVD-----HVRRPKKVAALQGKK-IISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSER----------LRPLPNPPL---------EYDLVRDLAPEALHARLILLHHFSELVCPCLAM-LPISG-----------DLSLGA----------------------LKDVLVYNIKE-----------AAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKL-FTALELPFSTSSARGHEV-PLSTRYTH------ISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEY 4884

HSP 2 Score: 162.925 bits (411), Expect = 2.850e-39
Identity = 117/374 (31.28%), Postives = 184/374 (49.20%), Query Frame = 2

Query: 4469 STYIWGCGIKGEAGFSTNDDWIKPTL-MNINGIQ--QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            +  +WG   K + G         PT    I+ ++   I  GS    +++ + K+ ACGEG        +         +PVL  Y +  V+   G + H +A+T+ G+VFSWG G  GKLGHG+ TTL KP+ +EALR K      CG  HSA +++ G LY +GLG  G+LG+   +    P+LV    G  ++  V+CG     TLAL+ DG  ++++G+G +GKLG G  +   +P  ++      ++++ CG  FS ALT  GEV+TWG  D+         +    + H+  P     L G   +I +  G     A+T+   +Y WG N +     G       P LV     + + +++CG +H+ A
Sbjct: 2987 TVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK-HALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGR-RVVQVACGSRDAQTLALTEDG-AVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYY-------RLGHGGDQHVRKPQPIGGLRG-RRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349

HSP 3 Score: 111.694 bits (278), Expect = 1.083e-23
Identity = 84/278 (30.22%), Postives = 137/278 (49.28%), Query Frame = 2

Query: 4778 GEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGK--GSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSY 5596
            G+V++ G G++G+LG G    +  P  +  LR      +    G  H+  +T  G ++ +G G +G+LG+   +  D PRLV+    + KI  V+CG +H+ A+S+ G+ LY +G G YG+LG GD   +  P LV     +++++V CG   + + ALTE+G V++WG  DF       SE   +D  H +       L GIG ++ +  G   + ALT    ++ WG      L  GG  H   P+ +   +   +  ++ G  H  A   A   Y
Sbjct: 3038 GKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAK-KIRDVACGSSHSAAISSQGE-LYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEG--SDTPHEI-----ERLSGIG-VVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVY 3305

HSP 4 Score: 109.768 bits (273), Expect = 3.842e-23
Identity = 93/329 (28.27%), Postives = 147/329 (44.68%), Query Frame = 2

Query: 4481 WGCGIKGEAGFSTNDDWIKPTLM---NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSN 5455
            W    K + GFS      +PTL       G+  + C   +  +  CE++++   +  ++      + E   +    V +D  I+     +G   H +AI      +SWG G   +LGHG       P  I AL         CG  +SA +T  G L  +G G   +LG+        P LV   +D       +  G  H+LAL+++G  ++A+G+G YGKLG G+      P LV+    ++ +V  G  FS AL+  G++YTWG +  +G  L +  V         VP L SSL     I+D+        AL+++  ++GWG N
Sbjct:  540 WPSLSKDQQGFSA-----EPTLSWSGESAGVPTLSCRFQIKQVACCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEG--RHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGL-VFAWGDGDYGKLGNGNCNGSLQPILVE-SLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCS-----VPRLVSSLQH-KRIVDVAVSVAHCLALSSSGEVFGWGRN 853

HSP 5 Score: 100.523 bits (249), Expect = 2.682e-20
Identity = 85/291 (29.21%), Postives = 126/291 (43.30%), Query Frame = 2

Query: 4721 THVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTP-RLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHA 5584
            +H  A+  PE  +        V  WG+    +LG    + +K P   + +     I    G     +V+  G +Y  G G NG+LG  +      P +L        K   V  G  H LAL+ DG K++++GEG  GKLG G+      P LV+  + KK+  V CG S SAA++  GE+YTWG  ++         +   D +  L P L ++L G   +   C   D  T ALT +  ++ WG      L  GG   +  P  +     I + QI CG   + A   A
Sbjct: 2972 SHEEAAAAPEQDLPCT-----VMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDG-KVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEY-------GRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRA 3249

HSP 6 Score: 79.337 bits (194), Expect = 6.055e-14
Identity = 63/225 (28.00%), Postives = 102/225 (45.33%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLG--VNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEG 5122
            +++ Y WG G     G         PT    +  + +Q + CG   +  ITC   L+  G G          ++      V  L+D+ +  V+   G ++H +A+T  G VF+WG G +GKLG+G+     +P  +E+L     + +  G   S  +++ G LY +G    +  QL    + GC  PRLV       +I  V+  + H LALS+ G+    FG G
Sbjct:  634 NHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSG-DAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFA--GSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQ-HKRIVDVAVSVAHCLALSSSGE---VFGWG 851

HSP 7 Score: 77.7962 bits (190), Expect = 1.601e-13
Identity = 57/181 (31.49%), Postives = 94/181 (51.93%), Query Frame = 2

Query: 4751 SHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKG--SIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEG--VYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSD 5278
            S+  AIT  G + +WG G++ +LGHG++     P  + AL       +    G  HS  +T+ G ++ +G G  G+LGN   +G   P LV+     P++  V  G   ++ALS++GQ LY +G+   +  +L    V+    P LV   Q K+++ V    +   AL+ +GEV+ WG +D
Sbjct:  678 SYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVE---SLPRVQRVFAGSQFSVALSSEGQ-LYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRND 854

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0310555)

HSP 1 Score: 121.709 bits (304), Expect = 5.730e-27
Identity = 103/365 (28.22%), Postives = 161/365 (44.11%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMNI-----NGIQQIVCGSGVTLLITCESKLMACGE------GLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG-HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLG---NEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPT-LVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALT-NNCHLYGWGSNANNLLRLGGKAHAYYPELV 5512
            Y WG    G+ G    +D    T   I       +QQ+ CG   TL +T   K+ ACG       G ++   P  R      + +P L DY I  +        H +A++ +G+V SWG    G+LGH      ++ PK +  L  K  +   CG+ HS  +T+ G LY +G  + GQLG      L+ C+ P  +    G P +  ++CG NH+  +S  G  ++ +G    G+LG+ D  +R  PT L   +   +  V CG  FS  LT  G V+T G   +  +G   S +E         ++P +   L+G   I  +  GN  T AL  +   +Y +G  ++  L          P++V
Sbjct:    8 YCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDL---PTKRPRMSPFLLIPELQDYVIIQICCGS---RHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIP-LAAIACGGNHSFLISKSG-AVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNE---------MLPRMVMELMG-STITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 354

HSP 2 Score: 101.679 bits (252), Expect = 7.083e-21
Identity = 79/266 (29.70%), Postives = 129/266 (48.50%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHG--HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDF----TDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKD--RFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCG 5554
            E++ WG  SHG+LG G      +  P  I            CGH H+  +TA+G +Y  G     QLG+++ +    PR+  F       +  I  + CG  H+LALS  GQ L ++G+   G+LG    K+  +    +     K ++++ CG + S ALT  GE+Y+WG S+  G    +S  DLT   H   P   ++L+GI      C GN  +F ++ +  ++GWG N    L L  + +  YP  +   + + ++ ++CG
Sbjct:    6 ELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPT--KRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVL-SWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWG-SNIYGQLGVNSPNDLT---HCNYPLRLTTLLGIPLAAIACGGNH-SFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACG 263

HSP 3 Score: 88.1965 bits (217), Expect = 8.427e-17
Identity = 90/363 (24.79%), Postives = 151/363 (41.60%), Query Frame = 2

Query: 6050 KEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDE--TISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFL-GILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--------NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFV-NRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDA--DINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANS-LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDM 7093
            +E +   + R++ +     L+ P    K+K   E A+DAGG   E   +           +F         + S  +   D T   +  +FL G+L   AI     I+L      +K++    V + DL ++ P   NS+ S+         E   L F+   +V+G  +  C   N  E  +     ++ VD+    DFV N+ +    + F        K F  +    ++ I     L  +V G++      L++   Y +    ++D I  WFWE++   +E EK  FL F+TG  R+P         L + I   P    LP + TCFN + LPRYK++  ++  L  AI Q +   +
Sbjct:  721 RENLVQDSLRELQHYSQSDLKKPL---KIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEY------EQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDL--YVDFVFNKSVELHYNAF-------HKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTI-KWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKA---LKLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061

HSP 4 Score: 82.0333 bits (201), Expect = 6.957e-15
Identity = 72/226 (31.86%), Postives = 110/226 (48.67%), Query Frame = 2

Query: 4928 ASGG-LYMFGLGVNGQLGNEILSGCD-----TPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLG--VGDVKDRFSPTLV--DFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGK---AHAYYPELVFFEKDIHLQQISCGRNHA 5566
            ASG  LY +G   +GQLG   L G +     TP  + +T  +  +  V+CG  HTL L+  G K+YA G   Y +LG  +   + R SP L+  + Q   ++++ CG   S AL++ G+V +WG +D             TD+  + +P +   LV    ++ +  GN+ + ALT+   LY WGSN    L +       H  YP  +     I L  I+CG NH+
Sbjct:    2 ASGKELYCWGSTSHGQLG---LGGIEDEQILTPSQIPWTP-DTAVQQVACGHRHTLFLTATG-KVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDND------CGQLGHATDKEIVQLPKVVRQLV-TKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHS 215

HSP 5 Score: 64.6994 bits (156), Expect = 1.166e-9
Identity = 53/185 (28.65%), Postives = 89/185 (48.11%), Query Frame = 2

Query: 5093 GQKLYAFGEGVYGKLGVGDVKDR--FSPTLVDFQKKKLL-KVICGKSFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIH------LQQISCGRNHAAA--SCHAPYSYRNTI 5608
            G++LY +G   +G+LG+G ++D    +P+ + +     + +V CG   +  LT  G+VY  G +D+  +G  L      ++    LL+P L   +     II +C G+  + AL++   +  WG N       G   HA   E+V   K +       + QI+CG NH+ A  SC   YS+ + I
Sbjct:    4 GKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPRMS--PFLLIPELQDYV-----IIQICCGSRHSLALSDWGQVLSWGDN-----DCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNI 176

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0072670)

HSP 1 Score: 120.168 bits (300), Expect = 1.439e-26
Identity = 102/359 (28.41%), Postives = 159/359 (44.29%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMNI-----NGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG-HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLG---NEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPT-LVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALT-NNCHLYGWGSNANNLLRLGGKAHAYYPELV 5512
            Y WG    G+ G    +D    T   I       +QQ+ CG   TL +T   K+ ACG          +   T R + +P L DY I  +        H +A++ +G+V SWG    G+LGH      ++ PK +  L  K  +   CG+ HS  +T+ G LY +G  + GQLG      L+ C+ P  +    G P +  ++CG NH+  +S  G  ++ +G    G+LG+ D  +R  PT L   +   +  V CG  FS  LT  G V+T G   +  +G   S +E         ++P +   L+G   I  +  GN  T AL  +   +Y +G  ++  L          P++V
Sbjct:    8 YCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDL--PTKRPLLIPELQDYVIIQICCGS---RHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIP-LAAIACGGNHSFLISKSG-AVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNE---------MLPRMVMELMG-STITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 349

HSP 2 Score: 102.834 bits (255), Expect = 3.241e-21
Identity = 79/264 (29.92%), Postives = 128/264 (48.48%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHG--HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCD--TPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKD--RFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCG 5554
            E++ WG  SHG+LG G      +  P  I            CGH H+  +TA+G +Y  G     QLG+++ +      P L D+      I  + CG  H+LALS  GQ L ++G+   G+LG    K+  +    +     K ++++ CG + S ALT  GE+Y+WG S+  G    +S  DLT   H   P   ++L+GI      C GN  +F ++ +  ++GWG N    L L  + +  YP  +   + + ++ ++CG
Sbjct:    6 ELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPLLIPELQDYV-----IIQICCGSRHSLALSDWGQVL-SWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWG-SNIYGQLGVNSPNDLT---HCNYPLRLTTLLGIPLAAIACGGNH-SFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACG 258

HSP 3 Score: 88.5817 bits (218), Expect = 7.470e-17
Identity = 90/363 (24.79%), Postives = 151/363 (41.60%), Query Frame = 2

Query: 6050 KEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDE--TISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFL-GILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--------NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFV-NRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDA--DINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANS-LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDM 7093
            +E +   + R++ +     L+ P    K+K   E A+DAGG   E   +           +F         + S  +   D T   +  +FL G+L   AI     I+L      +K++    V + DL ++ P   NS+ S+         E   L F+   +V+G  +  C   N  E  +     ++ VD+    DFV N+ +    + F        K F  +    ++ I     L  +V G++      L++   Y +    ++D I  WFWE++   +E EK  FL F+TG  R+P         L + I   P    LP + TCFN + LPRYK++  ++  L  AI Q +   +
Sbjct:  717 RENLVQDSLRELQHYSQSDLKKPL---KIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEY------EQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDL--YVDFVFNKSVELHYNAF-------HKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTI-KWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKA---LKLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1057

HSP 4 Score: 79.337 bits (194), Expect = 4.347e-14
Identity = 69/222 (31.08%), Postives = 107/222 (48.20%), Query Frame = 2

Query: 4928 ASGG-LYMFGLGVNGQLGNEILSGCD-----TPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGK---AHAYYPELVFFEKDIHLQQISCGRNHA 5566
            ASG  LY +G   +GQLG   L G +     TP  + +T  +  +  V+CG  HTL L+  G K+YA G   Y +LG  D+  +    + + Q   ++++ CG   S AL++ G+V +WG +D             TD+  + +P +   LV    ++ +  GN+ + ALT+   LY WGSN    L +       H  YP  +     I L  I+CG NH+
Sbjct:    2 ASGKELYCWGSTSHGQLG---LGGIEDEQILTPSQIPWTP-DTAVQQVACGHRHTLFLTATG-KVYACGSNDYSQLG-HDLPTKRPLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDND------CGQLGHATDKEIVQLPKVVRQLV-TKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHS 210

HSP 5 Score: 68.9366 bits (167), Expect = 6.487e-11
Identity = 54/183 (29.51%), Postives = 88/183 (48.09%), Query Frame = 2

Query: 5093 GQKLYAFGEGVYGKLGVGDVKDR--FSPTLVDFQKKKLL-KVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIH------LQQISCGRNHAAA--SCHAPYSYRNTI 5608
            G++LY +G   +G+LG+G ++D    +P+ + +     + +V CG   +  LT  G+VY  G +D+     S    DL  +  LL+P L   +     II +C G+  + AL++   +  WG N       G   HA   E+V   K +       + QI+CG NH+ A  SC   YS+ + I
Sbjct:    4 GKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDY-----SQLGHDLPTKRPLLIPELQDYV-----IIQICCGSRHSLALSDWGQVLSWGDN-----DCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNI 171

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0072671)

HSP 1 Score: 120.168 bits (300), Expect = 1.439e-26
Identity = 102/359 (28.41%), Postives = 159/359 (44.29%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMNI-----NGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG-HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLG---NEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPT-LVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALT-NNCHLYGWGSNANNLLRLGGKAHAYYPELV 5512
            Y WG    G+ G    +D    T   I       +QQ+ CG   TL +T   K+ ACG          +   T R + +P L DY I  +        H +A++ +G+V SWG    G+LGH      ++ PK +  L  K  +   CG+ HS  +T+ G LY +G  + GQLG      L+ C+ P  +    G P +  ++CG NH+  +S  G  ++ +G    G+LG+ D  +R  PT L   +   +  V CG  FS  LT  G V+T G   +  +G   S +E         ++P +   L+G   I  +  GN  T AL  +   +Y +G  ++  L          P++V
Sbjct:    8 YCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDL--PTKRPLLIPELQDYVIIQICCGS---RHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIP-LAAIACGGNHSFLISKSG-AVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNE---------MLPRMVMELMG-STITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 349

HSP 2 Score: 102.834 bits (255), Expect = 3.241e-21
Identity = 79/264 (29.92%), Postives = 128/264 (48.48%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHG--HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCD--TPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKD--RFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCG 5554
            E++ WG  SHG+LG G      +  P  I            CGH H+  +TA+G +Y  G     QLG+++ +      P L D+      I  + CG  H+LALS  GQ L ++G+   G+LG    K+  +    +     K ++++ CG + S ALT  GE+Y+WG S+  G    +S  DLT   H   P   ++L+GI      C GN  +F ++ +  ++GWG N    L L  + +  YP  +   + + ++ ++CG
Sbjct:    6 ELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPLLIPELQDYV-----IIQICCGSRHSLALSDWGQVL-SWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWG-SNIYGQLGVNSPNDLT---HCNYPLRLTTLLGIPLAAIACGGNH-SFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACG 258

HSP 3 Score: 88.5817 bits (218), Expect = 7.470e-17
Identity = 90/363 (24.79%), Postives = 151/363 (41.60%), Query Frame = 2

Query: 6050 KEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDE--TISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFL-GILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--------NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFV-NRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDA--DINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANS-LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDM 7093
            +E +   + R++ +     L+ P    K+K   E A+DAGG   E   +           +F         + S  +   D T   +  +FL G+L   AI     I+L      +K++    V + DL ++ P   NS+ S+         E   L F+   +V+G  +  C   N  E  +     ++ VD+    DFV N+ +    + F        K F  +    ++ I     L  +V G++      L++   Y +    ++D I  WFWE++   +E EK  FL F+TG  R+P         L + I   P    LP + TCFN + LPRYK++  ++  L  AI Q +   +
Sbjct:  717 RENLVQDSLRELQHYSQSDLKKPL---KIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEY------EQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDL--YVDFVFNKSVELHYNAF-------HKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTI-KWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKA---LKLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1057

HSP 4 Score: 79.337 bits (194), Expect = 4.347e-14
Identity = 69/222 (31.08%), Postives = 107/222 (48.20%), Query Frame = 2

Query: 4928 ASGG-LYMFGLGVNGQLGNEILSGCD-----TPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGK---AHAYYPELVFFEKDIHLQQISCGRNHA 5566
            ASG  LY +G   +GQLG   L G +     TP  + +T  +  +  V+CG  HTL L+  G K+YA G   Y +LG  D+  +    + + Q   ++++ CG   S AL++ G+V +WG +D             TD+  + +P +   LV    ++ +  GN+ + ALT+   LY WGSN    L +       H  YP  +     I L  I+CG NH+
Sbjct:    2 ASGKELYCWGSTSHGQLG---LGGIEDEQILTPSQIPWTP-DTAVQQVACGHRHTLFLTATG-KVYACGSNDYSQLG-HDLPTKRPLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDND------CGQLGHATDKEIVQLPKVVRQLV-TKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHS 210

HSP 5 Score: 68.9366 bits (167), Expect = 6.487e-11
Identity = 54/183 (29.51%), Postives = 88/183 (48.09%), Query Frame = 2

Query: 5093 GQKLYAFGEGVYGKLGVGDVKDR--FSPTLVDFQKKKLL-KVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIH------LQQISCGRNHAAA--SCHAPYSYRNTI 5608
            G++LY +G   +G+LG+G ++D    +P+ + +     + +V CG   +  LT  G+VY  G +D+     S    DL  +  LL+P L   +     II +C G+  + AL++   +  WG N       G   HA   E+V   K +       + QI+CG NH+ A  SC   YS+ + I
Sbjct:    4 GKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDY-----SQLGHDLPTKRPLLIPELQDYV-----IIQICCGSRHSLALSDWGQVLSWGDN-----DCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNI 171

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
Match: HUWE1 (gene:FBgn0030674 transcript:FBtr0339688)

HSP 1 Score: 106.301 bits (264), Expect = 4.895e-22
Identity = 101/382 (26.44%), Postives = 167/382 (43.72%), Query Frame = 2

Query: 6017 TSLVRIDRINKKEPVFIQTCRQVINMDA--VSLRLPWRAWK----VKLVNEGADDAGGAYDETISEICNELENE--AIFPRILTPIPSDTSTFIPNPDPTIPP---QYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLG----FDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRL-----HEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            T L R+D   ++E   +   R  +  D+  V  RL    WK    +   +E   DAGG   E    I  E+ N   A+F       P D  T++ NP     P    YF F+G ++A A+   K ++ +    F+K +    V   D+   D  ++  L  L  N+ ++LG    F +  + +GV +      N  +T +            N  ++V      ++      + D+ +E     F +I P  ++ I + + LE ++ G   I I+ LK    Y           WFW  L SF++ +++ FL+FVTG S++P     S +     + F I+   +  + LP + TCFNQ+ LP YKS   + +CL  AI +C
Sbjct: 4745 TELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALF----CVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTE---------ENKFEYVQLVCQLKMSGSIRQQLDAFLE----GFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHEC 5109

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Zebrafish
Match: herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:ZFIN;Acc:ZDB-GENE-030131-8542])

HSP 1 Score: 607.831 bits (1566), Expect = 1.546e-175
Identity = 454/1554 (29.21%), Postives = 723/1554 (46.53%), Query Frame = 2

Query: 2690 ILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQ-MTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTK----SIYSKPYVTSFSSLITTLIFPQQTSNGL-HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVIL--TDQICN-KFFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKL------TCVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLIT--------------------FC----------GHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTC-NGDGYVIGIEWTPQNNLVTAFSRSQYIKI----WRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLT-----GSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDN-IIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            + T+  +GT+R+W++     ++  L+QT +F+       +T D +     E C+  +  P    L+          +A S +G YLA ++   +NIW       S+  +P+       +++L +P++ +  L    P +LLLV    G L LL + D+ S +    +Q     ++ V   AW  E    A+GY +G +++   + + N    +   H   IS L ++P     G   L  S   E  + +W           TC+ S+  P  +  + W S      K  ++       GL+  W             T                    +C          GHM  V  +    +   L SG   G +N+WSL+D S++ T   G G +    W P   +    +RS+ + +      +  +N +     C+ A  ++  +    A        ++ F+  L  +L EQ+  E   V  G  +V+S Y+QCL   +  L L        + P+    P +  + +       IPS   +                 + +  WL      +K  +A+      P++ I+P    +  V  D+ A     SKW +         ++  W    PE W        ++WG G  G+   +  +  +     + +  QQ+VCG   T +I     + ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVT+ G L+ FG G  G+LG    S    P  V   +G  ++G V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P    +L G+ FI D+  G + T  L++   +Y WGSN+   L LG   H   P L+   +  ++QQIS GR H+AA    P   R    S P      +P     +Y+ L   E +   + ARL L+ ++++L+  +W+                   ++L   +    SR N+         W           ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+  +        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    +S++DL  +D  Y    NS+L + E + +   +  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+++LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+S M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3414 LATSGNDGTVRVWNVTK---SQYTLQQTCVFN-------KTDDSS-----EDCMSNLGSPGDPSLAP---------VAWSVSGKYLAAAMEKIVNIWQVNGGKVSLELQPH------WVSSLAWPEEEAGSLWGGEPRELLLVGRMDGTLGLLEVLDD-SDMQRTELQHCFRKDVAVMQIAWYSEDRPFAVGYADGKLLIGFKEPLENGSVVVIDAHKESISSLRWAP----GGQVLL--SCAKEEIVRLWTGSGTDLGQNWTCLQSIMHPAVVNAVAWCSLPGQGPKPLNMFATCCQNGLVSVWTVPQDPSSYSQSSTAYLDAWWESESRSRLMLKPQWCEGAVCVFQLRGHMTPVRTVAFSPDGLALVSGGVGGLLNIWSLRDGSVLQTVVAGSGAIHNTVWIPDVGVAVCSNRSKDVLVVNSSMEFMATNHVL--ATCRTALKKQGVVGLNMAPC------MRAFLERLPIMLQEQYAYEKPHVVCGEQLVHSPYMQCLASLSVGLQLDVLLCHPPVPPHMAHCPPEPGSSS-------IPSHGSWA----------------SSEWAWLHCFSTTIKTAEALARGHTFPESFIVPD---LEPVAKDKLALLMDNSKWVSGM-----DEQVMSWATSRPEDWHLGGKCDVFLWGAGRHGQLAEAGRNILVPTLAPSFSQAQQVVCGQNCTFVIQANGTVSACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQMVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFSFGNGDYGRLGLGNTSNKKLPERVSALEGH-QVGQVACGLNHTLAVSADGMTVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGNVYTFGQDRLIG--LPEGRARNHNR-----PQQVPALTGV-FIEDVAVGAEHTLTLSSTGDVYAWGSNSEGQLGLGHTNHVREPTLISALQGKNIQQISAGRCHSAAWTAPPVPPRAPGSSVPL--QLGLPVCVPPQYSALR--EVSMEALRARLRLLYHFSDLMYSSWRL------------------LNLSPNNQSCTSRYNA-------GTWG------IVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNAAAEVGYNRDRFLLNPSACLEEHLLQFKFLGILMGVAIRTKKPLDLHLAPMVWKQLCCIPLSLEDLEEVDLLYVQTLNSILHL-EDSGITEQNFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGLPEISVEVLKKVVRYREVDEQQQLVQWFWQTLDDFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQSVMAERLRYAINNCRSIDMDNYMLSRNVDN 4844

HSP 2 Score: 179.104 bits (453), Expect = 5.509e-44
Identity = 122/371 (32.88%), Postives = 187/371 (50.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHA-YYPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L  + +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA V+  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +V+  +   ++ +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     ++D+  G+    AL+++  +Y WG+N+      G        P+ V     + +QQIS G +H+ A
Sbjct:  370 YVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISSDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRAIKKVSSSKGSDGHTLAFTSEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVSEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELA-TTRVVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVIGLDGVAIQQISAGTSHSLA 727

HSP 3 Score: 88.9669 bits (219), Expect = 1.007e-16
Identity = 88/344 (25.58%), Postives = 146/344 (42.44%), Query Frame = 2

Query: 4706 NDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            +DY  T  S           ++   EV+ WG  S  +L  G    + +PK   +     +I  + G   + V+++ G +   G G  G+LG    +   T + + F   EP     K+        HTLA +++G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA++E+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  343 SDYSRTCASPDSIQAGEAAMVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISSDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRAIKKVSSSKGSDGHTLAFTSEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVSEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGM-FIRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELATTRVVDISIGDSHCLALSH 677

[Close]

Query: 2690 ILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQ-MTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTK----SIYSKPYVTSFSSLITTLIFPQQTSNGL-HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVIL--TDQICN-KFFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKL------TCVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLIT--------------------FC----------GHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTC-NGDGYVIGIEWTPQNNLVTAFSRSQYIKI----WRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLT-----GSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDN-IIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            + T+  +GT+R+W++     ++  L+QT +F+       +T D +     E C+  +  P    L+          +A S +G YLA ++   +NIW       S+  +P+       +++L +P++ +  L    P +LLLV    G L LL + D+ S +    +Q     ++ V   AW  E    A+GY +G +++   + + N    +   H   IS L ++P     G   L  S   E  + +W           TC+ S+  P  +  + W S      K  ++       GL+  W             T                    +C          GHM  V  +    +   L SG   G +N+WSL+D S++ T   G G +    W P   +    +RS+ + +      +  +N +     C+ A  ++  +    A        ++ F+  L  +L EQ+  E   V  G  +V+S Y+QCL   +  L L        + P+    P +  + +       IPS   +                 + +  WL      +K  +A+      P++ I+P    +  V  D+ A     SKW +         ++  W    PE W        ++WG G  G+   +  +  +     + +  QQ+VCG   T +I     + ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVT+ G L+ FG G  G+LG    S    P  V   +G  ++G V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P    +L G+ FI D+  G + T  L++   +Y WGSN+   L LG   H   P L+   +  ++QQIS GR H+AA    P   R    S P      +P     +Y+ L   E +   + ARL L+ ++++L+  +W+                   ++L   +    SR N+         W           ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+  +        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    +S++DL  +D  Y    NS+L + E + +   +  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+++LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+S M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3414 LATSGNDGTVRVWNVTK---SQYTLQQTCVFN-------KTDDSS-----EDCMSNLGSPGDPSLAP---------VAWSVSGKYLAAAMEKIVNIWQVNGGKVSLELQPH------WVSSLAWPEEEAGSLWGGEPRELLLVGRMDGTLGLLEVLDD-SDMQRTELQHCFRKDVAVMQIAWYSEDRPFAVGYADGKLLIGFKEPLENGSVVVIDAHKESISSLRWAP----GGQVLL--SCAKEEIVRLWTGSGTDLGQNWTCLQSIMHPAVVNAVAWCSLPGQGPKPLNMFATCCQNGLVSVWTVPQDPSSYSQSSTAYLDAWWESESRSRLMLKPQWCEGAVCVFQLRGHMTPVRTVAFSPDGLALVSGGVGGLLNIWSLRDGSVLQTVVAGSGAIHNTVWIPDVGVAVCSNRSKDVLVVNSSMEFMATNHVL--ATCRTALKKQGVVGLNMAPC------MRAFLERLPIMLQEQYAYEKPHVVCGEQLVHSPYMQCLASLSVGLQLDVLLCHPPVPPHMAHCPPEPGSSS-------IPSHGSWA----------------SSEWAWLHCFSTTIKTAEALARGHTFPESFIVPD---LEPVAKDKLALLMDNSKWVSGM-----DEQVMSWATSRPEDWHLGGKCDVFLWGAGRHGQLAEAGRNILVPTLAPSFSQAQQVVCGQNCTFVIQANGTVSACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQMVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFSFGNGDYGRLGLGNTSNKKLPERVSALEGH-QVGQVACGLNHTLAVSADGMTVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGNVYTFGQDRLIG--LPEGRARNHNR-----PQQVPALTGV-FIEDVAVGAEHTLTLSSTGDVYAWGSNSEGQLGLGHTNHVREPTLISALQGKNIQQISAGRCHSAAWTAPPVPPRAPGSSVPL--QLGLPVCVPPQYSALR--EVSMEALRARLRLLYHFSDLMYSSWRL------------------LNLSPNNQSCTSRYNA-------GTWG------IVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNAAAEVGYNRDRFLLNPSACLEEHLLQFKFLGILMGVAIRTKKPLDLHLAPMVWKQLCCIPLSLEDLEEVDLLYVQTLNSILHL-EDSGITEQNFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGLPEISVEVLKKVVRYREVDEQQQLVQWFWQTLDDFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQSVMAERLRYAINNCRSIDMDNYMLSRNVDN 4844

HSP 2 Score: 179.104 bits (453), Expect = 5.509e-44
Identity = 122/371 (32.88%), Postives = 187/371 (50.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHA-YYPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L  + +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA V+  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +V+  +   ++ +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     ++D+  G+    AL+++  +Y WG+N+      G        P+ V     + +QQIS G +H+ A
Sbjct:  370 YVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISSDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRAIKKVSSSKGSDGHTLAFTSEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVSEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELA-TTRVVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVIGLDGVAIQQISAGTSHSLA 727

HSP 3 Score: 88.9669 bits (219), Expect = 1.007e-16
Identity = 88/344 (25.58%), Postives = 146/344 (42.44%), Query Frame = 2

Query: 4706 NDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            +DY  T  S           ++   EV+ WG  S  +L  G    + +PK   +     +I  + G   + V+++ G +   G G  G+LG    +   T + + F   EP     K+        HTLA +++G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA++E+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  343 SDYSRTCASPDSIQAGEAAMVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISSDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRAIKKVSSSKGSDGHTLAFTSEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVSEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGM-FIRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELATTRVVDISIGDSHCLALSH 677

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Zebrafish
Match: LO018116.1 (pep chromosome:GRCz11:CHR_ALT_CTG6_1_36:37834788:37847878:1 gene:ENSDARG00000115404.1 transcript:ENSDART00000185717.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:LO018116.1)

HSP 1 Score: 223.402 bits (568), Expect = 1.136e-62
Identity = 130/364 (35.71%), Postives = 197/364 (54.12%), Query Frame = 2

Query: 6059 VFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-----FIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA++  F+++   + V    C    +  ++  H      + + N S++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct:   62 VFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKSPLHISMFRFLGVLLGIAIRTGSPLSLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEFEAMPLPFTVPS-ACGQEVQLSSKHSH------ISLENRSEYVRLAINYRLHEFDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGVEPTAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVVQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKLVLEEKLKYAIHFCKSIDTDDYARI 418

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Zebrafish
Match: herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-070718-6])

HSP 1 Score: 231.491 bits (589), Expect = 6.985e-60
Identity = 138/420 (32.86%), Postives = 219/420 (52.14%), Query Frame = 2

Query: 5933 VRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            +R  + S+   +   + +  +M+ +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA++  F+++   + V    C    +  ++  H      + + N S++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 4383 LRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKSPLHISMFRFLGVLLGIAIRTGSPLSLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEFEAMPLPFTVPS-ACGQEVQLSSKHSH------ISLENRSEYVRLAINYRLHEFDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGVEPTAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVVQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKLVLEEKLKYAIHFCKSIDTDDYARI 4795

HSP 2 Score: 157.147 bits (396), Expect = 2.441e-37
Identity = 123/435 (28.28%), Postives = 196/435 (45.06%), Query Frame = 2

Query: 4382 NNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLI 5659
            ++ +  +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GE++SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA +TASG LY +G G  G+LG+        P+LV+   G  ++  V+CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EI +I
Sbjct: 3918 HDLFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPTEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIRKVAVNSGGK-HCLALSSEGELYSWGEAEDGKLGHGNRSPCDRPRVIESLRGVEVVDIAAGGAHSACITASGELYTWGKGRYGRLGHGDSEDQLKPKLVEALQGH-RVIDVACGSGDAQTLCL-TDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSAHTLAWSTSKPTNAGKLPAQVPMEYNHLQEIAII 4340

HSP 3 Score: 152.14 bits (383), Expect = 8.346e-36
Identity = 116/374 (31.02%), Postives = 181/374 (48.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L++Y +  V+   G   H +A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P+LV    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+   F      D+    H+  P +   L G   I+ +  G     A+T    ++ WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2956 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGLSSGTIPIPRQISALSNYVVKKVAVHSGGR-HAMALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGH-RVVQVACGSRDAQTLALTDEGM-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY---FRLGHGTDV----HVRKPQMVEGLRG-KKIVHVAVGALHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3317

HSP 4 Score: 149.443 bits (376), Expect = 4.983e-35
Identity = 113/350 (32.29%), Postives = 172/350 (49.14%), Query Frame = 2

Query: 4436 SPEYWISEYSNS---TYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRG----KGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSN 5455
            SP    S  SN      + G G+ G   ++  +  I+   ++  G+ QIVC     L++T              ++    +  T   + V  L   KI  ++A    + H +A+++ GEVFSWG G  G+LGHG  T L++P  I    G    K  +   CG  +SA +TA G L+ +G G  G+LG+       TP LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P LV+  Q   ++KV CG  FS ALT++G+VYTWG  D       +  +    + H+  P L  SL G   ++D+  G+    ALT    ++ WGSN
Sbjct:  398 SPPQCSSPTSNKGTLQEVIGWGLLGWKPYANVNGPIQCKALSNLGVTQIVCSEKGFLILTITG----------AVYTQNYKSTTLAPMLVHALTSRKIMKLAAHPDGQ-HYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGELHTWGRGNYGRLGHGSSEDQTTPMLVTALKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGD-------NQRLGHGTDEHVRYPKLLDSLQG-KRVVDIAVGSTHCLALTEEGEVHSWGSN 726

HSP 5 Score: 107.071 bits (266), Expect = 3.331e-22
Identity = 85/313 (27.16%), Postives = 148/313 (47.28%), Query Frame = 2

Query: 4679 YRIINVPV----LNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGH---MHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP---KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKK-KLLKVICGK--SFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            Y  +N P+    L++  +T +  S   E   + +TI G V++            + +T   P  + AL  +  IM    H    H   ++ +G ++ +G G  G+LG+   +  + P ++    G P   ++  ++CG  ++ A++ DG+ L+ +G G YG+LG G  +D+ +P LV   K  K++ V CG   + + A+TENG+V++WG  D+  +G   SD             P L   L  +  I+ +C G+  + ALT +  +Y WG   N  L  G   H  YP+L+   +   +  I+ G  H  A
Sbjct:  426 YANVNGPIQCKALSNLGVTQIVCS---EKGFLILTITGAVYT----------QNYKSTTLAPMLVHALTSR-KIMKLAAHPDGQHYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGE-LHTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG---------CKTPKLVEKLQDLD-IVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGKRVVDIAVGSTHCLA 713

HSP 6 Score: 104.375 bits (259), Expect = 2.311e-21
Identity = 99/338 (29.29%), Postives = 146/338 (43.20%), Query Frame = 2

Query: 4607 CESKLMACG-EGLEMIFNPFMREETYRIINVPVL-------NDYKITHVSASK----GPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGC-DTPRLVD-FTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            C S  + C   GL  +    +R E   +  VP L        D K    S S+    G ES   A TI  +VF WG+    +LG    + +K P   E L     +    G      VTA G +Y  G   NG+LG  + SG    PR +   ++   K   V  G  H +AL+ DG K++++GEG  GKLG     +   P L++  + K++  + CG S SAA+T +GE+Y+WG  ++         +   D +  L P L   L+G   +   C   D  T ALT+   ++ WG      L  GG      P+ +       + QI CG   + A
Sbjct: 2889 CRSSGIDCKIHGLSAVGR--VRAEDEDLATVPFLASDNEEEEDEKTATGSMSRKRLSGLES---AATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGLSSGTIPIPRQISALSNYVVKKVAVHSGGRHAMALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEY-------GRLGHGDNTTQLRPKLVKVLLGHRVVQVACGSRDAQTLALTDEGMVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLA 3213

HSP 7 Score: 96.6709 bits (239), Expect = 4.824e-19
Identity = 64/231 (27.71%), Postives = 106/231 (45.89%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI-------NGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   + WGCG  G  G        +PT++++         +  I CGS  +  IT + +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK +E L+    +   CG   S  +T  G +Y +G G N +LG+        P+L+D   G+ ++  ++ G  H LAL+ +G+
Sbjct:  491 HPDGQHYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGELHTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGK-RVVDIAVGSTHCLALTEEGE 719

HSP 8 Score: 60.8474 bits (146), Expect = 3.190e-8
Identity = 44/154 (28.57%), Postives = 67/154 (43.51%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVT 4927
            + WG G  G+ G   ++    P     +N  G+ QI CG+  +L +T    +   G+G              +   V  L   KI HV+       H +A+T  G+VF+WG   HG+ G+G  T  +KP  ++ L G+      CG  HS   T
Sbjct: 3169 FSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQMVEGLRGKKIVHVAVGA---LHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3319

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Zebrafish
Match: herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-070718-6])

HSP 1 Score: 147.132 bits (370), Expect = 5.496e-35
Identity = 113/350 (32.29%), Postives = 172/350 (49.14%), Query Frame = 2

Query: 4436 SPEYWISEYSNS---TYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRG----KGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSN 5455
            SP    S  SN      + G G+ G   ++  +  I+   ++  G+ QIVC     L++T              ++    +  T   + V  L   KI  ++A    + H +A+++ GEVFSWG G  G+LGHG  T L++P  I    G    K  +   CG  +SA +TA G L+ +G G  G+LG+       TP LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P LV+  Q   ++KV CG  FS ALT++G+VYTWG  D       +  +    + H+  P L  SL G   ++D+  G+    ALT    ++ WGSN
Sbjct:  398 SPPQCSSPTSNKGTLQEVIGWGLLGWKPYANVNGPIQCKALSNLGVTQIVCSEKGFLILTITG----------AVYTQNYKSTTLAPMLVHALTSRKIMKLAAHPDGQ-HYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGELHTWGRGNYGRLGHGSSEDQTTPMLVTALKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGD-------NQRLGHGTDEHVRYPKLLDSLQG-KRVVDIAVGSTHCLALTEEGEVHSWGSN 726

HSP 2 Score: 105.916 bits (263), Expect = 3.412e-22
Identity = 90/337 (26.71%), Postives = 156/337 (46.29%), Query Frame = 2

Query: 4607 CESKLMACGEGLEMIFNPFMREETYRIINVPV----LNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGH---MHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP---KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKK-KLLKVICGK--SFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            C S     G   E+I    +  + Y  +N P+    L++  +T +  S   E   + +TI G V++            + +T   P  + AL  +  IM    H    H   ++ +G ++ +G G  G+LG+   +  + P ++    G P   ++  ++CG  ++ A++ DG+ L+ +G G YG+LG G  +D+ +P LV   K  K++ V CG   + + A+TENG+V++WG  D+  +G   SD             P L   L  +  I+ +C G+  + ALT +  +Y WG   N  L  G   H  YP+L+   +   +  I+ G  H  A
Sbjct:  402 CSSPTSNKGTLQEVIGWGLLGWKPYANVNGPIQCKALSNLGVTQIVCS---EKGFLILTITGAVYT----------QNYKSTTLAPMLVHALTSR-KIMKLAAHPDGQHYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGE-LHTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG---------CKTPKLVEKLQDLD-IVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGKRVVDIAVGSTHCLA 713

HSP 3 Score: 95.5153 bits (236), Expect = 5.574e-19
Identity = 64/231 (27.71%), Postives = 106/231 (45.89%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI-------NGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   + WGCG  G  G        +PT++++         +  I CGS  +  IT + +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK +E L+    +   CG   S  +T  G +Y +G G N +LG+        P+L+D   G+ ++  ++ G  H LAL+ +G+
Sbjct:  491 HPDGQHYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGELHTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGK-RVVDIAVGSTHCLALTEEGE 719

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
Match: HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:NCBI gene;Acc:100493988])

HSP 1 Score: 630.558 bits (1625), Expect = 0.000e+0
Identity = 491/1681 (29.21%), Postives = 774/1681 (46.04%), Query Frame = 2

Query: 2312 DTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMEL---LAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQS----------ILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQ-ICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLT--CVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQF-----------SDTGDDVKNLITF-----------C-----GHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLI-STCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGI---CQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNL-----TGSLMPYYVMEPIDASNRNKSLWM-LEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            +  L+  P+ ++ Q L    + +L+     ++ +Y   + E    +EL   LA   +S    S+ + W  Q L++    + ++      A   + D+  DL            C+ T  KL + +NR +          + T+  +GT+R+W++     T+ +L+QT +F                  ME   + T+P             +  I  S +G YLA +L   +NIW       K  V +    ++ L +P++ S      + P + LLV    G L L+ + D  S+     ++     E+ VT  AW  E    A+GY +G +++ ++ I  K    +   H + I  + + P     G   L  +   E  + +W K  L+   +  L+ P  +    W S   +        + G  +GL+  W             S   DD K  I F           C     GH+  V  +    +   L SG   G +N+WSLKD S++ S   G G V    W P   +    +RS+ + +   F    L  N +   C+ A  ++  +    A        ++ F+  L  +L EQ+  E   V  G  +V+S Y+QCL      LNL        + P++   P D ++ N + W+ LE     CF   I          L    Q    FT+ ++            +P+              +E       SKW N         ++  W    PE W        ++WG G  G+   +  +  I     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVTA G L+ FG G  G+LG    S    P  V   +G   IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P L   L+GI FI D+  G + T AL+ +  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA   AP   R    + P      +P++   +Y+ L   +   + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  ++  E+  +D FV  S +     I   G    +  +N  ++V+R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+D+LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3301 ENKLVTSPNFVVTQAL----VALLADKGAKLRPNYDKAEMEKRGPLELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTAPQTLADMAGDLR----------KCSFT--KLEAHQNRVTASVWCSKKDLLATSGSDGTVRVWNVSR---TQYSLQQTCVFH----------------KMEGSTEETDP------------SLSLICWSVSGRYLAGALEKTINIWQVNG--GKGLVDAQPHWVSALTWPEENSGAAWTSDAP-ESLLVGRMDGSLGLIEVTDASSM-QRMELEHCYRKEVAVTCIAWYSEDRSFAVGYSDGKLLIGNRDIAEKAGIVIIDAHKDMIVSMKWDPT----GQMLL--TCAKEETVKLWGKSGLSWKTLYCLSHPSLVNTAAWCS---LVGNGERPQLMGCQSGLVCVWIIPQIPQEGVQPKSSASDDWKEQIPFQEMFRKVEYVRCVFKLRGHITPVRTVAFSHDGLALVSGGLGGLMNIWSLKDGSVLQSVVTGSGAVTTTVWIPDVGVAACSNRSKDVLVVN-FTPEWLSSNHVLATCRTALKQQGIVGLNMAPC------MQTFLERLPVMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLNLDRLLCNPPVPPHHYPSPPDPASWNPTEWVWLE-----CFSTTI-----KAAEALARGSQFPECFTVPDL----------EPVPE--------------EELKLVMDNSKWNNG-----TDEQIMSWATSKPEDWHLGGKCDVFLWGAGRHGQLAEAGRNVMIPSGAGSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTADGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGL-HIGQVACGLNHTLAVSADGSLVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQLVPVLLGI-FIDDIAVGAEHTLALSASGEVYAWGSNSEGQLGLGHTNHVREPTLVTALQGKNIRQISAGRCHSAAWTAAPVPPRAPGVAVPL--QLGLPDVIPPQYSCL--KDICLHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQSSASHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNATAEVGYNRDRFLLNPSSGLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEENFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVDRAIDYRLHEMDRQVAAVREGMSWIIPVPLLSLLTARQLEQMVCGMPEISVDVLKKVVRYREVDEQHQLVQWFWQTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPHDSLPTSQTCFFQLRLPPYSSQPVMAERLRYAINNCRSIDMDNYMLSRNVDN 4825

HSP 2 Score: 181.415 bits (459), Expect = 1.477e-44
Identity = 124/371 (33.42%), Postives = 185/371 (49.87%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHA-YYPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L    +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +V+  +    + +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     + +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFTRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGVAIQQISAGTSHSLA 732

HSP 3 Score: 88.5817 bits (218), Expect = 2.057e-16
Identity = 85/319 (26.65%), Postives = 136/319 (42.63%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK         +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ F   +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGM-FTRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
Match: HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:NCBI gene;Acc:100493988])

HSP 1 Score: 619.002 bits (1595), Expect = 5.553e-179
Identity = 481/1634 (29.44%), Postives = 751/1634 (45.96%), Query Frame = 2

Query: 2441 QIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQS----------ILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQ-ICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLT--CVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQF-----------SDTGDD---------------VKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLI-STCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGI---CQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLM-----PYYVMEPIDASNRNKSLWM-LEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            ++   LA   +S    S+ + W  Q L++    + ++      A   + D+  DL            C+ T  KL + +NR +          + T+  +GT+R+W++     T+ +L+QT +F                    K    TE     LS          I  S +G YLA +L   +NIW       K  V +    ++ L +P++ S      + P + LLV    G L L+ + D  S+     ++     E+ VT  AW  E    A+GY +G +++ ++ I  K    +   H + I  + + P     G   L  +   E  + +W K  L+   +  L+ P  +    W S   +        + G  +GL+  W             S   DD               V+ +    GH+  V  +    +   L SG   G +N+WSLKD S++ S   G G V    W P   +    +RS+ + +   F    L  N +   C+ A  ++  +    A        ++ F+  L  +L EQ+  E   V  G  +V+S Y+QCL      LNL   L      P++   P D ++ N + W+ LE     CF   I          L    Q    FT+ ++            +P+              +E       SKW N         ++  W    PE W        ++WG G  G+   +  +  I     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVTA G L+ FG G  G+LG    S    P  V   +G   IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P L   L+GI FI D+  G + T AL+ +  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA   AP   R    + P      +P++   +Y+ L   +   + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  ++  E+  +D FV  S +     I   G    +  +N  ++V+R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+D+LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3331 ELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTAPQTLADMAGDLR----------KCSFT--KLEAHQNRVTASVWCSKKDLLATSGSDGTVRVWNVSR---TQYSLQQTCVF-------------------HKMCGSTEETDPSLSL---------ICWSVSGRYLAGALEKTINIWQVNG--GKGLVDAQPHWVSALTWPEENSGAAWTSDAP-ESLLVGRMDGSLGLIEVTDASSM-QRMELEHCYRKEVAVTCIAWYSEDRSFAVGYSDGKLLIGNRDIAEKAGIVIIDAHKDMIVSMKWDPT----GQMLL--TCAKEETVKLWGKSGLSWKTLYCLSHPSLVNTAAWCS---LVGNGERPQLMGCQSGLVCVWIIPQIPQEGVQPKSSASDDWKEQAISKVREKVEYVRCVFKLRGHITPVRTVAFSHDGLALVSGGLGGLMNIWSLKDGSVLQSVVTGSGAVTTTVWIPDVGVAACSNRSKDVLVVN-FTPEWLSSNHVLATCRTALKQQGIVGLNMAPC------MQTFLERLPVMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLNLDRLLCNPPVPPHHYPSPPDPASWNPTEWVWLE-----CFSTTI-----KAAEALARGSQFPECFTVPDL----------EPVPE--------------EELKLVMDNSKWNNG-----TDEQIMSWATSKPEDWHLGGKCDVFLWGAGRHGQLAEAGRNVMIPSGAGSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTADGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGL-HIGQVACGLNHTLAVSADGSLVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQLVPVLLGI-FIDDIAVGAEHTLALSASGEVYAWGSNSEGQLGLGHTNHVREPTLVTALQGKNIRQISAGRCHSAAWTAAPVPPRAPGVAVPL--QLGLPDVIPPQYSCL--KDICLHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQSSASHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNATAEVGYNRDRFLLNPSSGLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEENFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVDRAIDYRLHEMDRQVAAVREGMSWIIPVPLLSLLTARQLEQMVCGMPEISVDVLKKVVRYREVDEQHQLVQWFWQTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPHDSLPTSQTCFFQLRLPPYSSQPVMAERLRYAINNCRSIDMDNYMLSRNVDN 4812

HSP 2 Score: 180.644 bits (457), Expect = 2.590e-44
Identity = 124/371 (33.42%), Postives = 185/371 (49.87%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY-YPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L    +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +V+  +    + +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     + +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFTRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGVAIQQISAGTSHSLA 732

HSP 3 Score: 88.1965 bits (217), Expect = 2.494e-16
Identity = 85/319 (26.65%), Postives = 136/319 (42.63%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK         +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ F   +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGM-FTRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
Match: HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:100487407])

HSP 1 Score: 351.288 bits (900), Expect = 4.898e-96
Identity = 268/941 (28.48%), Postives = 426/941 (45.27%), Query Frame = 2

Query: 4400 KQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNP--DPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA +TA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      + KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +PS    ++  + EI +I         ++  ++    I +                          +DL         LD + +  S           +       IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    T+    F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFW+++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3825 EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDIAAGGAHSACITAAGELYTWGKGRYGRLGHGDSEDQLKPKLVEALQGY-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGVGVTKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSAHTLAWSTSKPANAGKLPSQVPMEYNHLQEIMIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------RLDESGQGPS---------IGFDTLRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMASFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKTTLHMNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAM--------ILPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAIGYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPTASLIQWFWDVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4696

HSP 2 Score: 152.14 bits (383), Expect = 1.108e-35
Identity = 116/374 (31.02%), Postives = 181/374 (48.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L++Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+   F      D+    H+  P +   L G   I+ +  G     A+T+   +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2857 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLALTKSGVVWTWGKGDY---FRLGHGTDV----HVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQKITRVACGSSHSVA 3218

HSP 3 Score: 116.701 bits (291), Expect = 6.499e-25
Identity = 94/288 (32.64%), Postives = 143/288 (49.65%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A++   E+FSWG G            L  P  + AL GK +    I   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  VSCG     TL+++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS A+T++G+VY+WG  D       +  +    E H+  P + + L G   ++D+  G+    ALT +  +Y WGSN      + LR+     +  P L       H+  ISCG  ++ A +SC
Sbjct:  412 HYLALSATSELFSWGCGD----------VLFCPL-VSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLGHGSSEDQTVPMLVTGLKGL-KVVDVSCGSGDAQTLSVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKIMNGLQG-KKVVDVAVGSTHCLALTESGEVYSWGSNDQCQHFDTLRIAKPVPSVLPGL----DSKHIVGISCGPAQSFAWSSC 674

HSP 4 Score: 104.76 bits (260), Expect = 2.311e-21
Identity = 85/310 (27.42%), Postives = 144/310 (46.45%), Query Frame = 2

Query: 4688 INVPVLND-YKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG-HATTLKKPKSIEALRG--KGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSY 5596
            I VP  ++     +V    G    + A+T  G+V++ G  ++G+LG G  + T+  P+ I AL       +    G  H+  +T  G ++ +G G +G+LG+     CD PRL++    + +I  ++CG +H+ A+++ G+ LY +G G YG+LG GD   +  P +V      ++++V CG   + + ALT+ G V++WG  DF       SE          +P     L G       C G   + ALT +  ++ WG      L  G   H   P++V   +   +  ++ G  H  A   A   Y
Sbjct: 2875 IKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAAITSSGE-LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSE-------GCNIPQNIERLNGQAVCQIEC-GAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVY 3174

HSP 5 Score: 103.219 bits (256), Expect = 7.350e-21
Identity = 83/272 (30.51%), Postives = 122/272 (44.85%), Query Frame = 2

Query: 4769 TIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSG-CDTPR-LVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            TI  +VF WG+    +LG    + +K P   E L     +    G      VTA G +Y  G   NG+LG  I SG    PR +   ++   K   V  G  H  AL+ DG K++++GEG  GKLG     +   P L++  + K++  + CG S SAA+T +GE+YTWG  ++         +   D +  L P +   L+G   I   C   D  T ALT+   ++ WG      L  GG      P+ +       + QI CG   + A
Sbjct: 2851 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGRHATALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYTWGLGEY-------GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLA 3114

HSP 6 Score: 93.2041 bits (230), Expect = 8.487e-18
Identity = 65/214 (30.37%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT +G +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3012 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQ-KITRVACGSSHSVAWTT 3221

HSP 7 Score: 87.8113 bits (216), Expect = 3.071e-16
Identity = 67/236 (28.39%), Postives = 108/236 (45.76%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQ------QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFG 5116
            + D   Y     ++  + WGCG          D    P +  ++G Q       I CGS  +  IT + +L   G G          E+    + V  L   K+  VS   G ++  +++T  G+V+SWG G +GKLG G +   K PK IE L+    +   CG   S  +T  G +Y +G G N +LG+        P++++   G+ K+  V+ G  H LAL+  G+ +Y++G
Sbjct:  407 HPDGQHYLALSATSELFSWGCG----------DVLFCPLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLGHGSSEDQTVPMLVTGLKGLKVVDVSCGSG-DAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGDNQRLGHGTEEHVRYPKIMNGLQGK-KVVDVAVGSTHCLALTESGE-VYSWG 629

HSP 8 Score: 80.4925 bits (197), Expect = 4.858e-14
Identity = 77/284 (27.11%), Postives = 124/284 (43.66%), Query Frame = 2

Query: 4745 PESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFT---DGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKK----LLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLC-AGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            P SH  A+    EV SWG+     LG  +   +  P   EAL   G     C      +++ +G LY      N  LG +++ G  +  +V      DG+           H LALS   + L+++G         GDV   F P +     K+    ++ + CG ++SAA+T +GE+YTWG  ++ G     S  D T      VP L + L G+  +   C +G+  T ++T N  ++ WG      L  GG      P+L+   +D+ + ++ CG   + A
Sbjct:  321 PTSHKGALQ---EVISWGL-----LGWKYYANVSGPIQCEALANLGVTQVACAEKCFLILSRNGKLYTQAYN-NNTLGPQLVQGLASRNIVKIAAHPDGQ-----------HYLALSATSE-LFSWG--------CGDV--LFCPLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNY-GRLGHGSSEDQT------VPMLVTGLKGLKVVDVSCGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIA 566

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
Match: HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:100487407])

HSP 1 Score: 351.288 bits (900), Expect = 5.024e-96
Identity = 268/941 (28.48%), Postives = 426/941 (45.27%), Query Frame = 2

Query: 4400 KQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNP--DPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA +TA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      + KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +PS    ++  + EI +I         ++  ++    I +                          +DL         LD + +  S           +       IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    T+    F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFW+++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3903 EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDIAAGGAHSACITAAGELYTWGKGRYGRLGHGDSEDQLKPKLVEALQGY-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGVGVTKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSAHTLAWSTSKPANAGKLPSQVPMEYNHLQEIMIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------RLDESGQGPS---------IGFDTLRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMASFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKTTLHMNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAM--------ILPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAIGYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPTASLIQWFWDVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4774

HSP 2 Score: 152.14 bits (383), Expect = 1.066e-35
Identity = 116/374 (31.02%), Postives = 181/374 (48.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L++Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+   F      D+    H+  P +   L G   I+ +  G     A+T+   +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2935 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLALTKSGVVWTWGKGDY---FRLGHGTDV----HVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQKITRVACGSSHSVA 3296

HSP 3 Score: 116.701 bits (291), Expect = 5.988e-25
Identity = 94/288 (32.64%), Postives = 143/288 (49.65%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A++   E+FSWG G            L  P  + AL GK +    I   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  VSCG     TL+++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS A+T++G+VY+WG  D       +  +    E H+  P + + L G   ++D+  G+    ALT +  +Y WGSN      + LR+     +  P L       H+  ISCG  ++ A +SC
Sbjct:  493 HYLALSATSELFSWGCGD----------VLFCPL-VSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLGHGSSEDQTVPMLVTGLKGL-KVVDVSCGSGDAQTLSVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKIMNGLQG-KKVVDVAVGSTHCLALTESGEVYSWGSNDQCQHFDTLRIAKPVPSVLPGL----DSKHIVGISCGPAQSFAWSSC 755

HSP 4 Score: 105.145 bits (261), Expect = 2.058e-21
Identity = 85/310 (27.42%), Postives = 144/310 (46.45%), Query Frame = 2

Query: 4688 INVPVLND-YKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG-HATTLKKPKSIEALRG--KGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSY 5596
            I VP  ++     +V    G    + A+T  G+V++ G  ++G+LG G  + T+  P+ I AL       +    G  H+  +T  G ++ +G G +G+LG+     CD PRL++    + +I  ++CG +H+ A+++ G+ LY +G G YG+LG GD   +  P +V      ++++V CG   + + ALT+ G V++WG  DF       SE          +P     L G       C G   + ALT +  ++ WG      L  G   H   P++V   +   +  ++ G  H  A   A   Y
Sbjct: 2953 IKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAAITSSGE-LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSE-------GCNIPQNIERLNGQAVCQIEC-GAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVY 3252

HSP 5 Score: 103.219 bits (256), Expect = 6.885e-21
Identity = 83/272 (30.51%), Postives = 122/272 (44.85%), Query Frame = 2

Query: 4769 TIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSG-CDTPR-LVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            TI  +VF WG+    +LG    + +K P   E L     +    G      VTA G +Y  G   NG+LG  I SG    PR +   ++   K   V  G  H  AL+ DG K++++GEG  GKLG     +   P L++  + K++  + CG S SAA+T +GE+YTWG  ++         +   D +  L P +   L+G   I   C   D  T ALT+   ++ WG      L  GG      P+ +       + QI CG   + A
Sbjct: 2929 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGRHATALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYTWGLGEY-------GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLA 3192

HSP 6 Score: 93.2041 bits (230), Expect = 7.687e-18
Identity = 65/214 (30.37%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT +G +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3090 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQ-KITRVACGSSHSVAWTT 3299

HSP 7 Score: 87.8113 bits (216), Expect = 2.949e-16
Identity = 67/236 (28.39%), Postives = 108/236 (45.76%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQ------QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFG 5116
            + D   Y     ++  + WGCG          D    P +  ++G Q       I CGS  +  IT + +L   G G          E+    + V  L   K+  VS   G ++  +++T  G+V+SWG G +GKLG G +   K PK IE L+    +   CG   S  +T  G +Y +G G N +LG+        P++++   G+ K+  V+ G  H LAL+  G+ +Y++G
Sbjct:  488 HPDGQHYLALSATSELFSWGCG----------DVLFCPLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLGHGSSEDQTVPMLVTGLKGLKVVDVSCGSG-DAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGDNQRLGHGTEEHVRYPKIMNGLQGK-KVVDVAVGSTHCLALTESGE-VYSWG 710

HSP 8 Score: 80.8777 bits (198), Expect = 4.289e-14
Identity = 77/284 (27.11%), Postives = 122/284 (42.96%), Query Frame = 2

Query: 4745 PESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFT---DGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKK----LLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            P SH  A+    EV SWG+     LG  +   +  P   EAL   G     C      +++ +G LY      N  LG +++ G  +  +V      DG+           H LALS   + L+++G         GDV   F P +     K+    ++ + CG ++SAA+T +GE+YTWG  ++ G     S  D T      VP L + L G+  +   C   D  T ++T N  ++ WG      L  GG      P+L+   +D+ + ++ CG   + A
Sbjct:  402 PTSHKGALQ---EVISWGL-----LGWKYYANVSGPIQCEALANLGVTQVACAEKCFLILSRNGKLYTQAYN-NNTLGPQLVQGLASRNIVKIAAHPDGQ-----------HYLALSATSE-LFSWG--------CGDV--LFCPLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNY-GRLGHGSSEDQT------VPMLVTGLKGLKVVDVSCGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIA 647

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
Match: HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:100487407])

HSP 1 Score: 351.288 bits (900), Expect = 5.068e-96
Identity = 268/941 (28.48%), Postives = 426/941 (45.27%), Query Frame = 2

Query: 4400 KQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNP--DPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA +TA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      + KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +PS    ++  + EI +I         ++  ++    I +                          +DL         LD + +  S           +       IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    T+    F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFW+++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3906 EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDIAAGGAHSACITAAGELYTWGKGRYGRLGHGDSEDQLKPKLVEALQGY-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGVGVTKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSAHTLAWSTSKPANAGKLPSQVPMEYNHLQEIMIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------RLDESGQGPS---------IGFDTLRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMASFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKTTLHMNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAM--------ILPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAIGYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPTASLIQWFWDVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4777

HSP 2 Score: 152.14 bits (383), Expect = 1.066e-35
Identity = 116/374 (31.02%), Postives = 181/374 (48.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L++Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+   F      D+    H+  P +   L G   I+ +  G     A+T+   +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2938 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLALTKSGVVWTWGKGDY---FRLGHGTDV----HVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQKITRVACGSSHSVA 3299

HSP 3 Score: 116.701 bits (291), Expect = 6.193e-25
Identity = 94/288 (32.64%), Postives = 143/288 (49.65%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A++   E+FSWG G            L  P  + AL GK +    I   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  VSCG     TL+++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS A+T++G+VY+WG  D       +  +    E H+  P + + L G   ++D+  G+    ALT +  +Y WGSN      + LR+     +  P L       H+  ISCG  ++ A +SC
Sbjct:  493 HYLALSATSELFSWGCGD----------VLFCPL-VSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLGHGSSEDQTVPMLVTGLKGL-KVVDVSCGSGDAQTLSVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKIMNGLQG-KKVVDVAVGSTHCLALTESGEVYSWGSNDQCQHFDTLRIAKPVPSVLPGL----DSKHIVGISCGPAQSFAWSSC 755

HSP 4 Score: 105.145 bits (261), Expect = 2.076e-21
Identity = 85/310 (27.42%), Postives = 144/310 (46.45%), Query Frame = 2

Query: 4688 INVPVLND-YKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG-HATTLKKPKSIEALRG--KGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSY 5596
            I VP  ++     +V    G    + A+T  G+V++ G  ++G+LG G  + T+  P+ I AL       +    G  H+  +T  G ++ +G G +G+LG+     CD PRL++    + +I  ++CG +H+ A+++ G+ LY +G G YG+LG GD   +  P +V      ++++V CG   + + ALT+ G V++WG  DF       SE          +P     L G       C G   + ALT +  ++ WG      L  G   H   P++V   +   +  ++ G  H  A   A   Y
Sbjct: 2956 IKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAAITSSGE-LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSE-------GCNIPQNIERLNGQAVCQIEC-GAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVY 3255

HSP 5 Score: 103.219 bits (256), Expect = 7.120e-21
Identity = 83/272 (30.51%), Postives = 122/272 (44.85%), Query Frame = 2

Query: 4769 TIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSG-CDTPR-LVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            TI  +VF WG+    +LG    + +K P   E L     +    G      VTA G +Y  G   NG+LG  I SG    PR +   ++   K   V  G  H  AL+ DG K++++GEG  GKLG     +   P L++  + K++  + CG S SAA+T +GE+YTWG  ++         +   D +  L P +   L+G   I   C   D  T ALT+   ++ WG      L  GG      P+ +       + QI CG   + A
Sbjct: 2932 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSGGRHATALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYTWGLGEY-------GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLA 3195

HSP 6 Score: 93.2041 bits (230), Expect = 8.152e-18
Identity = 65/214 (30.37%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT +G +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3093 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQAVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQ-KITRVACGSSHSVAWTT 3302

HSP 7 Score: 87.8113 bits (216), Expect = 3.207e-16
Identity = 67/236 (28.39%), Postives = 108/236 (45.76%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQ------QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFG 5116
            + D   Y     ++  + WGCG          D    P +  ++G Q       I CGS  +  IT + +L   G G          E+    + V  L   K+  VS   G ++  +++T  G+V+SWG G +GKLG G +   K PK IE L+    +   CG   S  +T  G +Y +G G N +LG+        P++++   G+ K+  V+ G  H LAL+  G+ +Y++G
Sbjct:  488 HPDGQHYLALSATSELFSWGCG----------DVLFCPLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLGHGSSEDQTVPMLVTGLKGLKVVDVSCGSG-DAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGDNQRLGHGTEEHVRYPKIMNGLQGK-KVVDVAVGSTHCLALTESGE-VYSWG 710

HSP 8 Score: 80.8777 bits (198), Expect = 4.218e-14
Identity = 77/284 (27.11%), Postives = 122/284 (42.96%), Query Frame = 2

Query: 4745 PESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFT---DGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKK----LLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            P SH  A+    EV SWG+     LG  +   +  P   EAL   G     C      +++ +G LY      N  LG +++ G  +  +V      DG+           H LALS   + L+++G         GDV   F P +     K+    ++ + CG ++SAA+T +GE+YTWG  ++ G     S  D T      VP L + L G+  +   C   D  T ++T N  ++ WG      L  GG      P+L+   +D+ + ++ CG   + A
Sbjct:  402 PTSHKGALQ---EVISWGL-----LGWKYYANVSGPIQCEALANLGVTQVACAEKCFLILSRNGKLYTQAYN-NNTLGPQLVQGLASRNIVKIAAHPDGQ-----------HYLALSATSE-LFSWG--------CGDV--LFCPLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNY-GRLGHGSSEDQT------VPMLVTGLKGLKVVDVSCGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDIVKVRCGSQFSIA 647

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
Match: Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:MGI Symbol;Acc:MGI:2384589])

HSP 1 Score: 610.912 bits (1574), Expect = 1.673e-176
Identity = 480/1664 (28.85%), Postives = 757/1664 (45.49%), Query Frame = 2

Query: 2321 LLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMEL---LAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQ--TSNGLHETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVIL-TDQICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDK--LTCVLSLNEPITC--IEWLSRKYINDKNHHVIIAGLSTGLIQFW-------------------QFSDTGDD------VKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCN-GDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNL------KNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNI-IPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            L+  P+ ++ Q L    + +L+     ++ +Y   + E +  +EL   LA   +S    S+ + W  Q L++    + ++      A   + D+  DL       I L      V   +    +  + T+  +GT+R+W++      + +L+QT +F           +R      E     ++P                ++ S +G YLA +L   +NIW       K  V      ++ L +P++   +    E+P +LLLV    G L L+ + D  S +    ++     +++VT  AW  E    A+GY +G +++ T +   K    L   H   +  + + P T H   T        E N+ +W        C+ SL  P T   I W S      K   ++  G   GL+  W                   Q S+  D        K +    GH+  V  +    +   L SG   G +N+WSL+D S++ T   G G +    W P+  +    +RS+          + L  N   +WA    +      A   + +  L      + F+  L  +L EQ+  E   V  G  +V+S Y+QCL      L+L   L       P+   ++N       +P  T +                PN +  WL      +K  +A+      P++  +P    +  V  DE       SKW N         ++  W    PE W        Y+WG G  G+   +  +  +  T  + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVT+ G L+ FG G  G+LG    S    P  V   +G  +IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P     L G+  I D+  G + T AL +   +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA    P   R    S P      +P+    +Y  L   E + + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  +S  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ + LE++VCG   I +D+LK + RY + D    +  W W  L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3324 LVTSPNFVVTQAL----VALLADKGAKLRPNYDKTEIEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTAPQTLADMGGDL--RKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTK---KQYSLQQTCVF-----------NRLEGDAEESLGSPSDP------------SFSPVSWSISGKYLAGALEKMVNIWQVNG--GKGLVDIQPHWVSALAWPEEGPATTWSGESP-ELLLVGRMDGSLGLIEVVDV-STMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLMGTKEPLEKGGIVLIDAHKETLVSMKWDP-TGHILMT-----CAKEENVKLWGPVSGCWRCLHSLCHPSTVNGIAWCSLPGKGSKMQLLMATGCQNGLVCVWRIPQDTTQTSMTSSEGWWDQESNCQDGYRKSAGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSK----------DVLVVNCTAEWASANHILATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLL----CNPPVPPHHQNC------LPDPTSWN---------------PN-EWAWLECFSTTIKAAEALTNGAQFPESFTVPD---LEPVPEDELVLLMDNSKWINGM-----DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQQIPVLAGV-VIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNIRQISAGRCHSAAWTAPPVPPRAPGVSVPL--QLGLPDAVPPQYGALR--EVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIV--DLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDN 4851

HSP 2 Score: 181.415 bits (459), Expect = 1.120e-44
Identity = 123/371 (33.15%), Postives = 187/371 (50.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY-YPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L  + +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +++  +   ++ +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    +L+++  +Y WG+N+      G        P+ V     I +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDISIGDSHCLSLSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732

HSP 3 Score: 89.3521 bits (220), Expect = 7.579e-17
Identity = 85/319 (26.65%), Postives = 138/319 (43.26%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK   +     +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  +  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGM-FIRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLSLSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
Match: Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:103234])

HSP 1 Score: 363.999 bits (933), Expect = 4.526e-100
Identity = 299/1099 (27.21%), Postives = 481/1099 (43.77%), Query Frame = 2

Query: 3926 LKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            L   +  L + L  QF  E  +V+ G  +++S + + L+     L L    +P         +  +K  W         F+R  +   + +   L     L  LF +DEV K  + +  + +  D +                 H   S +K      +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD                    P   F+   +R  + S+   +   + +  +M+ +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3779 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLEL--DTLPC-------CAETHKWAW---------FRRYCMASRVAV--ALDKRTPLPRLF-LDEVAKKIRELMADSESMDVL-----------------HESHSIFKR-----EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------SLDET---------------GLGPSVGFDT--LRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4765

HSP 2 Score: 149.828 bits (377), Expect = 4.430e-35
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ +CGE         M   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2963 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3324

HSP 3 Score: 144.821 bits (364), Expect = 1.207e-33
Identity = 102/288 (35.42%), Postives = 150/288 (52.08%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A+   GEV+SWG G  G+LGHG    L++PK I A  GK +    +   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS ALT++G+VY+WG  D       +  +    E H+  P L   L G   +ID+ AG+    ALT +  ++ WGSN      + LR+        P L       H+  I+CG  ++ A +SC
Sbjct:  507 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKLLEGLQG-KKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGL----DSKHIVGIACGPAQSFAWSSC 780

HSP 4 Score: 94.3597 bits (233), Expect = 2.219e-18
Identity = 69/231 (29.87%), Postives = 104/231 (45.02%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   Y WGCG  G  G        +P +++    +Q       I CGS  +  IT E +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK IE L+    I   CG   S  +T  G +Y +G G N +LG+        P+L++   G+ K+  V+ G  H LAL+ D +
Sbjct:  502 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK-KVIDVAAGSTHCLALTEDSE 730

HSP 5 Score: 93.9745 bits (232), Expect = 3.078e-18
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3118 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3327

HSP 6 Score: 60.077 bits (144), Expect = 5.189e-8
Identity = 53/210 (25.24%), Postives = 94/210 (44.76%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            Y WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G    +    R  +       ++   +   V   +      IA+T  G+V+SWG G + +LGHG    ++ PK +E L+GK  I    G  H   +T    ++ +G     Q  + +      P  +   D +  +G ++CG   + A S+
Sbjct:  574 YTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG---DYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGLDSKHIVG-IACGPAQSFAWSS 779

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
Match: Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:103234])

HSP 1 Score: 363.999 bits (933), Expect = 4.821e-100
Identity = 299/1099 (27.21%), Postives = 481/1099 (43.77%), Query Frame = 2

Query: 3926 LKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            L   +  L + L  QF  E  +V+ G  +++S + + L+     L L    +P         +  +K  W         F+R  +   + +   L     L  LF +DEV K  + +  + +  D +                 H   S +K      +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD                    P   F+   +R  + S+   +   + +  +M+ +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3815 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLEL--DTLPC-------CAETHKWAW---------FRRYCMASRVAV--ALDKRTPLPRLF-LDEVAKKIRELMADSESMDVL-----------------HESHSIFKR-----EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------SLDET---------------GLGPSVGFDT--LRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4801

HSP 2 Score: 149.828 bits (377), Expect = 4.147e-35
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ +CGE         M   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2963 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3324

HSP 3 Score: 144.821 bits (364), Expect = 1.209e-33
Identity = 102/288 (35.42%), Postives = 150/288 (52.08%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A+   GEV+SWG G  G+LGHG    L++PK I A  GK +    +   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS ALT++G+VY+WG  D       +  +    E H+  P L   L G   +ID+ AG+    ALT +  ++ WGSN      + LR+        P L       H+  I+CG  ++ A +SC
Sbjct:  507 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKLLEGLQG-KKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGL----DSKHIVGIACGPAQSFAWSSC 780

HSP 4 Score: 94.7449 bits (234), Expect = 2.184e-18
Identity = 69/231 (29.87%), Postives = 104/231 (45.02%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   Y WGCG  G  G        +P +++    +Q       I CGS  +  IT E +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK IE L+    I   CG   S  +T  G +Y +G G N +LG+        P+L++   G+ K+  V+ G  H LAL+ D +
Sbjct:  502 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK-KVIDVAAGSTHCLALTEDSE 730

HSP 5 Score: 93.9745 bits (232), Expect = 3.029e-18
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3118 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3327

HSP 6 Score: 60.077 bits (144), Expect = 5.368e-8
Identity = 53/210 (25.24%), Postives = 94/210 (44.76%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            Y WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G    +    R  +       ++   +   V   +      IA+T  G+V+SWG G + +LGHG    ++ PK +E L+GK  I    G  H   +T    ++ +G     Q  + +      P  +   D +  +G ++CG   + A S+
Sbjct:  574 YTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG---DYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGLDSKHIVG-IACGPAQSFAWSS 779

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
Match: Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:103234])

HSP 1 Score: 363.999 bits (933), Expect = 4.821e-100
Identity = 299/1099 (27.21%), Postives = 481/1099 (43.77%), Query Frame = 2

Query: 3926 LKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            L   +  L + L  QF  E  +V+ G  +++S + + L+     L L    +P         +  +K  W         F+R  +   + +   L     L  LF +DEV K  + +  + +  D +                 H   S +K      +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD                    P   F+   +R  + S+   +   + +  +M+ +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3815 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLEL--DTLPC-------CAETHKWAW---------FRRYCMASRVAV--ALDKRTPLPRLF-LDEVAKKIRELMADSESMDVL-----------------HESHSIFKR-----EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------SLDET---------------GLGPSVGFDT--LRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4801

HSP 2 Score: 149.828 bits (377), Expect = 4.147e-35
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ +CGE         M   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2963 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3324

HSP 3 Score: 144.821 bits (364), Expect = 1.209e-33
Identity = 102/288 (35.42%), Postives = 150/288 (52.08%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A+   GEV+SWG G  G+LGHG    L++PK I A  GK +    +   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS ALT++G+VY+WG  D       +  +    E H+  P L   L G   +ID+ AG+    ALT +  ++ WGSN      + LR+        P L       H+  I+CG  ++ A +SC
Sbjct:  507 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKLLEGLQG-KKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGL----DSKHIVGIACGPAQSFAWSSC 780

HSP 4 Score: 94.7449 bits (234), Expect = 2.184e-18
Identity = 69/231 (29.87%), Postives = 104/231 (45.02%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   Y WGCG  G  G        +P +++    +Q       I CGS  +  IT E +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK IE L+    I   CG   S  +T  G +Y +G G N +LG+        P+L++   G+ K+  V+ G  H LAL+ D +
Sbjct:  502 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK-KVIDVAAGSTHCLALTEDSE 730

HSP 5 Score: 93.9745 bits (232), Expect = 3.029e-18
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3118 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3327

HSP 6 Score: 60.077 bits (144), Expect = 5.368e-8
Identity = 53/210 (25.24%), Postives = 94/210 (44.76%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            Y WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G    +    R  +       ++   +   V   +      IA+T  G+V+SWG G + +LGHG    ++ PK +E L+GK  I    G  H   +T    ++ +G     Q  + +      P  +   D +  +G ++CG   + A S+
Sbjct:  574 YTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG---DYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGLDSKHIVG-IACGPAQSFAWSS 779

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
Match: Hectd3 (HECT domain E3 ubiquitin protein ligase 3 [Source:MGI Symbol;Acc:MGI:1923858])

HSP 1 Score: 142.895 bits (359), Expect = 1.424e-33
Identity = 99/343 (28.86%), Postives = 163/343 (47.52%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNEL-ENEAIFPRILTPIPSDTST-------------FIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSV---NKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISK---QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W+ K + EG  D GG + ++++++  EL  + A  P    P+P    T             ++PNP      +Y  ++G LM  A+R K+ + L L    WK+++   VS         S    LL + E    G D     +   K + F+    ++   E+   G    V+  + S F+      RL E    +  ++     + P  +LD+++W+ LEK VCG   +++D L+ + R+ D + +D    +FWE L +F   ++S FLRFVTG+SRLP+       R++IY  K   +  ++LP+S TC + + LP Y S    E  LR A   C +ID D
Sbjct:  528 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTP---VPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKY-EWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVME----GVDKETFEFKFGKELTFTTVLSDQQVVELIPGGTGIVVEYEDRSRFIQLVRKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPA-------RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
Match: sp|Q15751|HERC1_HUMAN (Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2)

HSP 1 Score: 605.134 bits (1559), Expect = 8.793e-174
Identity = 475/1677 (28.32%), Postives = 753/1677 (44.90%), Query Frame = 2

Query: 2321 LLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMEL---LAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVIL-TDQICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDK--LTCVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQF-SDT------------------------GDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCN-GDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNL------KNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQ-------------LHWLFTIDEVMKLTQAICFERDIPDNI-IPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            L+  P+ ++ Q L    + +L+     ++ +Y   + E +  +EL   LA   +S    S+ + W  Q L++    + ++          + D+  DL       I L      V   +    +  + T+  +GT+R+W++      + +L+QT +F           +R      E     ++P                ++ S +G YLA +L   +NIW       K  V      ++ L +P++        E+P +LLLV    G L L+ + D  S +    ++     +++VT  AW  E    A+GY +G ++L T +   K    L   H + +  + + P T H   T        E+++ +W        C+ SL  P  +  I W        K   ++  G  +GL+  W+   DT                            K +    GH+  V  +    +   L SG   G +N+WSL+D S++ T   G G +    W P+  +    +RS+          + L  N   +WA    +      A   + +  L      + F+  L  +L EQ+  E   V  G  +V+S Y+QCL      L+L                                         L  N  +PP+HQ               WL      +K  +A+      P++  +P    +  V  DE       SKW N         ++  W    PE W        Y+WG G  G+   +  +  +     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVT+ G L+ FG G  G+LG    S    P  V   +G  +IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  +D      + KV CG  FS ALT++G VYT+G    +G  L +      +      P     L G+  I D+  G + T AL +N  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA    P   R    S P      +P+    +Y  L   E + + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  +S  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ + LE++VCG   IS+++LK + RY + D    +  WFW  L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3326 LVTSPNFVVTQAL----VALLADKGAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTTLQTLADMGGDL--RKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTK---KQYSLQQTCVF-----------NRLEGDAEESLGSPSDP------------SFSPVSWSISGKYLAGALEKMVNIWQVNG--GKGLVDIQPHWVSALAWPEEGPATAWSGESP-ELLLVGRMDGSLGLIEVVDV-STMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDP-TGHILMT-----CAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSK----------DVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHL---------------------------------------DQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPD---LEPVPEDELVFLMDNSKWINGM-----DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQQIPVLAGV-IIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL--QLGLPDTVPPQYGALR--EVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIV--DLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDN 4853

HSP 2 Score: 181.8 bits (460), Expect = 6.566e-44
Identity = 124/371 (33.42%), Postives = 187/371 (50.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY-YPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L  + +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +++  +   ++ +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     I +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732

HSP 3 Score: 89.7373 bits (221), Expect = 4.835e-16
Identity = 85/319 (26.65%), Postives = 138/319 (43.26%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK   +     +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  +S G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGM-FIRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
Match: sp|Q4U2R1|HERC2_MOUSE (E3 ubiquitin-protein ligase HERC2 OS=Mus musculus OX=10090 GN=Herc2 PE=1 SV=3)

HSP 1 Score: 363.999 bits (933), Expect = 3.372e-99
Identity = 299/1099 (27.21%), Postives = 481/1099 (43.77%), Query Frame = 2

Query: 3926 LKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            L   +  L + L  QF  E  +V+ G  +++S + + L+     L L    +P         +  +K  W         F+R  +   + +   L     L  LF +DEV K  + +  + +  D +                 H   S +K      +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD                    P   F+   +R  + S+   +   + +  +M+ +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3815 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLEL--DTLPC-------CAETHKWAW---------FRRYCMASRVAV--ALDKRTPLPRLF-LDEVAKKIRELMADSESMDVL-----------------HESHSIFKR-----EQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVIDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHISELFCPCIPM--------------------------FDLEG------SLDET---------------GLGPSVGFDT--LRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4801

HSP 2 Score: 149.828 bits (377), Expect = 2.901e-34
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ +CGE         M   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2963 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3324

HSP 3 Score: 144.821 bits (364), Expect = 8.455e-33
Identity = 102/288 (35.42%), Postives = 150/288 (52.08%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A+   GEV+SWG G  G+LGHG    L++PK I A  GK +    +   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS ALT++G+VY+WG  D       +  +    E H+  P L   L G   +ID+ AG+    ALT +  ++ WGSN      + LR+        P L       H+  I+CG  ++ A +SC
Sbjct:  507 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKLLEGLQG-KKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGL----DSKHIVGIACGPAQSFAWSSC 780

HSP 4 Score: 94.7449 bits (234), Expect = 1.528e-17
Identity = 69/231 (29.87%), Postives = 104/231 (45.02%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   Y WGCG  G  G        +P +++    +Q       I CGS  +  IT E +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK IE L+    I   CG   S  +T  G +Y +G G N +LG+        P+L++   G+ K+  V+ G  H LAL+ D +
Sbjct:  502 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK-KVIDVAAGSTHCLALTEDSE 730

HSP 5 Score: 93.9745 bits (232), Expect = 2.119e-17
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3118 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3327

HSP 6 Score: 60.077 bits (144), Expect = 3.755e-7
Identity = 53/210 (25.24%), Postives = 94/210 (44.76%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            Y WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G    +    R  +       ++   +   V   +      IA+T  G+V+SWG G + +LGHG    ++ PK +E L+GK  I    G  H   +T    ++ +G     Q  + +      P  +   D +  +G ++CG   + A S+
Sbjct:  574 YTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG---DYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGLDSKHIVG-IACGPAQSFAWSS 779

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
Match: sp|O95714|HERC2_HUMAN (E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2)

HSP 1 Score: 357.836 bits (917), Expect = 2.244e-97
Identity = 270/947 (28.51%), Postives = 430/947 (45.41%), Query Frame = 2

Query: 4382 NNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIP--PQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQK-VDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            ++ +  +Q  +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA VTA+G LY +G G  G+LG+        P+LV+   G  ++  ++CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP+I         ++  ++    I +                          +DL        SLD      S           +       IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+EIC EL+N      I+TP   D S      ++ +P    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++         + F+V     +      K   + ++N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   + +  +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3922 HDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH-RVVDIACGSGDAQTLCL-TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPM--------------------------FDLEG------SLDETGLGPS---------VGFDTLRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMS--------LPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4799

HSP 2 Score: 149.443 bits (376), Expect = 3.578e-34
Identity = 114/374 (30.48%), Postives = 180/374 (48.13%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   +  L+ Y +  V+   G   H  A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P++V    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+         +    + H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2962 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF-------RLGHGSDVHVRKPQVVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3323

HSP 3 Score: 146.362 bits (368), Expect = 2.988e-33
Identity = 103/288 (35.76%), Postives = 151/288 (52.43%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNAN----NLLRLGGKAHAYYPELVFFEKDIHLQQISCG--RNHAAASC 5578
            H +A+   GEV+SWG G  G+LGHG    L++PK I A  GK +    +   CG  +SA +TA G LY +G G  G+LG+        P LV    G  K+  V+CG     TLA++ +GQ ++++G+G YGKLG G      +P L++  Q   ++KV CG  FS ALT++G+VY+WG  D       +  +    E H+  P L   L G   +ID+ AG+    ALT +  ++ WGSN      + LR+     A  P L       H+  I+CG  ++ A +SC
Sbjct:  506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGD-------NQRLGHGTEEHVRYPKLLEGLQG-KKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGL----DTKHIVGIACGPAQSFAWSSC 779

HSP 4 Score: 94.3597 bits (233), Expect = 1.884e-17
Identity = 68/231 (29.44%), Postives = 104/231 (45.02%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   Y     +   Y WGCG  G  G        +P +++    +Q       I CGS  +  IT E +L   G G          E+    + V  L   K+  V+   G ++  +A+T  G+V+SWG G +GKLG G +   K PK IE L+    +   CG   S  +T  G +Y +G G N +LG+        P+L++   G+ K+  V+ G  H LAL+ D +
Sbjct:  501 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG-DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK-KVIDVAAGSTHCLALTEDSE 729

HSP 5 Score: 94.3597 bits (233), Expect = 1.998e-17
Identity = 66/214 (30.84%), Postives = 103/214 (48.13%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   +KP ++ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++WG G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3117 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3326

HSP 6 Score: 60.4622 bits (145), Expect = 3.424e-7
Identity = 53/210 (25.24%), Postives = 94/210 (44.76%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            Y WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G    +    R  +       ++   +   V   +      IA+T  G+V+SWG G + +LGHG    ++ PK +E L+GK  I    G  H   +T    ++ +G     Q  + +      P  +   D +  +G ++CG   + A S+
Sbjct:  573 YTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG---DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVG-IACGPAQSFAWSS 778

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
Match: sp|Q9VR91|HERC2_DROME (Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila melanogaster OX=7227 GN=HERC2 PE=1 SV=3)

HSP 1 Score: 330.102 bits (845), Expect = 6.387e-89
Identity = 264/941 (28.06%), Postives = 427/941 (45.38%), Query Frame = 2

Query: 4403 QQTELFQWYQDSPEYWISEY--SNSTYIWGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALS-TDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYD------MTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK---------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTP-----IPSDTSTFIPNP--DPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLL---SMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIY--ISKQPANS-LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDY 7102
               +L QW    P+ W   +  +++ Y WG   +G+ G         PT    +++    Q+  G      +T + KL A G G          +       +  L    +  V+ + G + H +A+T  GEV++WG G  GKLGHG+  +  +PK +E L G       CG  HSA +TASG +  +G G  G+LG+        P+LV+   G   I  ++CG      L  TD   ++++G+G YGKLG G       P  ++      ++KV CG  FS ALT++G VYTWG  DF    L    VD     H+  P   ++L G   II +  G+    A +++  +Y WG N    L  G       P LV   +  H+ +++CG  H  A   +  S R           + +P  PL         EY+         + ARLIL+ +++ELV       +P +             +SLG+                       K    +NI E           +   + I  +M+ ++ +  ++ ++RI  K               + VF Q  +++  +   +L LP R WKVK V E  DD GG Y E+I+E+C+EL+N ++   I TP       ++   F+ +P     +    F FLG+LM  A+RT  P+ ++L    W+++T  ++   DL  +D  Y   LL   +M++   L F +L+  +         V    T   H      +   N +++V   + +RLHEFD  ++ +R     + P+ +L + S   L+ +VCGS  I + +LK++A Y   D +  + +WFWE++  F   E+SLFLRFV G++RLP   +    R F+   + K P +  LP+S TCF  +++PRY  ++ +   L+ AI  C+SID D+Y
Sbjct: 4026 HDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGK-HCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAID-IACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDF--HRLGHGSVD-----HVRRPKKVAALQGKK-IISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSER----------LRPLPNPPL---------EYDLVRDLAPEALHARLILLHHFSELVCPCLAM-LPISG-----------DLSLGA----------------------LKDVLVYNIKE-----------AAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKL-FTALELPFSTSSARGHEV-PLSTRYTH------ISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEY 4884

HSP 2 Score: 162.925 bits (411), Expect = 2.856e-38
Identity = 117/374 (31.28%), Postives = 184/374 (49.20%), Query Frame = 2

Query: 4469 STYIWGCGIKGEAGFSTNDDWIKPTL-MNINGIQ--QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            +  +WG   K + G         PT    I+ ++   I  GS    +++ + K+ ACGEG        +         +PVL  Y +  V+   G + H +A+T+ G+VFSWG G  GKLGHG+ TTL KP+ +EALR K      CG  HSA +++ G LY +GLG  G+LG+   +    P+LV    G  ++  V+CG     TLAL+ DG  ++++G+G +GKLG G  +   +P  ++      ++++ CG  FS ALT  GEV+TWG  D+         +    + H+  P     L G   +I +  G     A+T+   +Y WG N +     G       P LV     + + +++CG +H+ A
Sbjct: 2987 TVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK-HALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGR-RVVQVACGSRDAQTLALTEDG-AVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYY-------RLGHGGDQHVRKPQPIGGLRG-RRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349

HSP 3 Score: 111.694 bits (278), Expect = 1.086e-22
Identity = 84/278 (30.22%), Postives = 137/278 (49.28%), Query Frame = 2

Query: 4778 GEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGK--GSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSY 5596
            G+V++ G G++G+LG G    +  P  +  LR      +    G  H+  +T  G ++ +G G +G+LG+   +  D PRLV+    + KI  V+CG +H+ A+S+ G+ LY +G G YG+LG GD   +  P LV     +++++V CG   + + ALTE+G V++WG  DF       SE   +D  H +       L GIG ++ +  G   + ALT    ++ WG      L  GG  H   P+ +   +   +  ++ G  H  A   A   Y
Sbjct: 3038 GKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAK-KIRDVACGSSHSAAISSQGE-LYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEG--SDTPHEI-----ERLSGIG-VVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVY 3305

HSP 4 Score: 109.768 bits (273), Expect = 3.851e-22
Identity = 93/329 (28.27%), Postives = 147/329 (44.68%), Query Frame = 2

Query: 4481 WGCGIKGEAGFSTNDDWIKPTLM---NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSN 5455
            W    K + GFS      +PTL       G+  + C   +  +  CE++++   +  ++      + E   +    V +D  I+     +G   H +AI      +SWG G   +LGHG       P  I AL         CG  +SA +T  G L  +G G   +LG+        P LV   +D       +  G  H+LAL+++G  ++A+G+G YGKLG G+      P LV+    ++ +V  G  FS AL+  G++YTWG +  +G  L +  V         VP L SSL     I+D+        AL+++  ++GWG N
Sbjct:  540 WPSLSKDQQGFSA-----EPTLSWSGESAGVPTLSCRFQIKQVACCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEG--RHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGL-VFAWGDGDYGKLGNGNCNGSLQPILVE-SLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCS-----VPRLVSSLQH-KRIVDVAVSVAHCLALSSSGEVFGWGRN 853

HSP 5 Score: 100.523 bits (249), Expect = 2.689e-19
Identity = 85/291 (29.21%), Postives = 126/291 (43.30%), Query Frame = 2

Query: 4721 THVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTP-RLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHA 5584
            +H  A+  PE  +        V  WG+    +LG    + +K P   + +     I    G     +V+  G +Y  G G NG+LG  +      P +L        K   V  G  H LAL+ DG K++++GEG  GKLG G+      P LV+  + KK+  V CG S SAA++  GE+YTWG  ++         +   D +  L P L ++L G   +   C   D  T ALT +  ++ WG      L  GG   +  P  +     I + QI CG   + A   A
Sbjct: 2972 SHEEAAAAPEQDLPCT-----VMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDG-KVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEY-------GRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRA 3249

HSP 6 Score: 79.337 bits (194), Expect = 6.069e-13
Identity = 63/225 (28.00%), Postives = 102/225 (45.33%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLG--VNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEG 5122
            +++ Y WG G     G         PT    +  + +Q + CG   +  ITC   L+  G G          ++      V  L+D+ +  V+   G ++H +A+T  G VF+WG G +GKLG+G+     +P  +E+L     + +  G   S  +++ G LY +G    +  QL    + GC  PRLV       +I  V+  + H LALS+ G+    FG G
Sbjct:  634 NHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSG-DAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFA--GSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQ-HKRIVDVAVSVAHCLALSSSGE---VFGWG 851

HSP 7 Score: 77.7962 bits (190), Expect = 1.605e-12
Identity = 57/181 (31.49%), Postives = 94/181 (51.93%), Query Frame = 2

Query: 4751 SHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKG--SIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEG--VYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSD 5278
            S+  AIT  G + +WG G++ +LGHG++     P  + AL       +    G  HS  +T+ G ++ +G G  G+LGN   +G   P LV+     P++  V  G   ++ALS++GQ LY +G+   +  +L    V+    P LV   Q K+++ V    +   AL+ +GEV+ WG +D
Sbjct:  678 SYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVE---SLPRVQRVFAGSQFSVALSSEGQ-LYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRND 854

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
Match: sp|Q3U487|HECD3_MOUSE (E3 ubiquitin-protein ligase HECTD3 OS=Mus musculus OX=10090 GN=Hectd3 PE=1 SV=2)

HSP 1 Score: 142.895 bits (359), Expect = 9.959e-33
Identity = 99/343 (28.86%), Postives = 163/343 (47.52%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNEL-ENEAIFPRILTPIPSDTST-------------FIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSV---NKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISK---QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W+ K + EG  D GG + ++++++  EL  + A  P    P+P    T             ++PNP      +Y  ++G LM  A+R K+ + L L    WK+++   VS         S    LL + E    G D     +   K + F+    ++   E+   G    V+  + S F+      RL E    +  ++     + P  +LD+++W+ LEK VCG   +++D L+ + R+ D + +D    +FWE L +F   ++S FLRFVTG+SRLP+       R++IY  K   +  ++LP+S TC + + LP Y S    E  LR A   C +ID D
Sbjct:  528 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTP---VPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKY-EWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVME----GVDKETFEFKFGKELTFTTVLSDQQVVELIPGGTGIVVEYEDRSRFIQLVRKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPA-------RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
Match: A0A210R2T9 (E3 ubiquitin-protein ligase HERC1 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT14666 PE=4 SV=1)

HSP 1 Score: 641.728 bits (1654), Expect = 0.000e+0
Identity = 470/1621 (28.99%), Postives = 748/1621 (46.14%), Query Frame = 2

Query: 2441 QIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDL-----SIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTS--NGLHETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQICNKF---FLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLT-CVLSL---NEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFW-----------QFSDTG------------------DDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLD--EVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREND 7129
            Q++  LA  ++S       K W  + L++     + +S P     VN VDL  DL     S  +     LA C  + KK +       + T+  +GT+R+W + +   T Q L+QT +F+ G+ +L                        DL  +L+     NI  S  G  LA S+   +N+WST     K  +      ++ L +P   S   G      D+LLV    G L +L I   GS      ++  S   + VT+ AW +E    A GY +G VI++++  + F    +   H N I  L + P T H     L + +  +N + +W   +   C+L L   + P+    W S     D  H ++ +G   GL+  W           Q +  G                    +K + T  GHM SV  +    +  +LASGC  GWVN+W L +  L+ T   +G V  + W     L   F+R + + I  Y N+   QK      A  +   L+      +     L+  +  L  +L +Q+L E  +V SG  +V+S YLQCL      L+L   L                           C  + ++ H  N  +      +  WL +    +K   A+      PD+             ++   +       N  W L   T++  W    PE W        ++WG G  G+        ++   + + +  Q+++CG   T +I     ++ACGEG          ++ + +  +  L  + +  ++ S G + H + +T  GEVFSWG G +GKLGHG++   ++P+ IEAL+ +  +   CG  HSAVV+A G L+ FG G  G+LG   +     P  V   +G  +IGFV+CG+NHTL +S+DG+ ++AFG+G YGKLG+G+   +  P  ++  Q + + KV CG  FS AL+++G V+TWG    +G      + +     H+  P   ++L G  ++ D+  G + T ALT    ++ WG+N+   L +G        P+LV      +++QIS GR H+AA    P   R   P  P      IP+    +YT L  +  +  D+  R  L+ ++++L+  +W+  +P T+     + Y+     +          ++ +L                     R  ++    +  + R I  +M+  + Y   + + R++ +    +PVF Q  +QV+ + A  LRLP RAWKVKL+ EGADDAGG +D+TI+E+C ELE   +   I TP   + S      F+ NP  T   +   F FLGIL   AIRTKKP+DLH  P  WK +    +  +DL  +D  Y  SL+ +++    G +  +  E   +D F+  S +     +   G   ++  +N  D+V   + +RLHE D     +R+    I P+ +L ++S R LE++VCG + +++DIL+ + RY   D  + +  WFWE+L SF+  E+  FLRFV+G++RLP++ S I  R  I  S + A+ LP SQTCF Q+RLP Y SR  +   LR AI  CRSIDMD+YML RN END
Sbjct: 3347 QLINALAGCVLSTKLPPSHKQWAAKQLLQSLSSHRHSSSPL----VNQVDLGGDLPHCQVSKLEGHQNRLAMCQWSQKKSM-------LATSGYDGTLRVWSLPN--KTHQFLQQTCVFNRGEDLLGE----------------------DLDGHLLD----NICWSANGRLLAGSMDNLVNVWSTGGC--KGILDVQDHWVSALAWPSHKSMVGGCLGMTTDILLVGRLDGSLAVLEIL-GGSSFNRKELEHCSRNSVAVTLLAWYDEDRNFAAGYSDGVVIISNR--SDFETPVITETHQNCIIGLSWDP-TGHL----LLTCAEKDNCVKVWLPGREGLCLLYLLPDSAPVCSAMWCSIPGKGDSKHLLLASGNEMGLVSMWTVPQRQSTSQTQITPFGIRRETVYENQNMECMEQVRTIKPVRTLHGHMTSVTSMTFSPDGLMLASGCTRGWVNIWCLSNGCLLQTHVENGTVNDLCWYADYGLAICFNRIKDVVILHY-NAELHQKTRCVAMARKK---LKQQGIVGLNQAPCLQGLLQQLPTMLQDQYLSEKPMVVSGHQLVHSSYLQCLASLAVGLSLEHVL---------------------------CHNQTLIHHQHNAEDQDLLVTEWQWLLSYSAAIKSADALAQRTPFPDSFKRL---------NKDTRNGGSVPMDNGRWDLNMDTQIMLWALQRPEDWQLGGKCEVFLWGSGRHGQICEGGRASFVPTKVSSFSCAQKVICGQNCTFVIQSNGTILACGEGSYGRLGQGNSDDHHALTAISSLQGFVVIQLATSVGSDGHSLTLTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQREEIVQLSCGFKHSAVVSADGKLFCFGNGEYGRLGLGNIVNKKIPHRVTALEGH-QIGFVACGLNHTLCVSSDGKNVWAFGDGDYGKLGLGNTTGKHLPAKIEALQAQTIKKVACGAQFSVALSKDGRVFTWGQDRLIG------QPEFRGRGHM-TPQEVTALSGY-YVEDVVCGAEHTLALTCTGDVWAWGNNSEGQLGIGHTNTPVREPQLVPCLTGKNIKQISAGRTHSAAWTAQPPPQRK--PGVPLPLQLGIPDGIPPQYTAL--TAVSLEDIQGRFKLLHHFSDLIYSSWRL-LPLTSTQSTLTRYETGMRGI----------IDGRL---------------------RPLLSPRVYTLPLVRAIGKTMVQGKNYGPQITVKRLSTRGKKCKPVFTQIAQQVVKLKAEDLRLPARAWKVKLIGEGADDAGGVFDDTITEMCQELEMRVVPLLITTPNAQNESGNNRDRFLLNPSLTSDEEMEMFKFLGILCGVAIRTKKPLDLHFAPCVWKLLVGIPLQHEDLEEVDHLYIQSLIGISDIQKSGVNETNFHEFIPLDSFLGQSSDGRLIPVISGGSTIRLHFHNRRDYVEAALNFRLHEMDRQAAAVREGMAWIVPVPLLTLLSPRVLEQMVCGMEDMNVDILRKVVRYRGIDEKNEVVRWFWEVLESFSNDERIQFLRFVSGRTRLPANPSDISQRFQIMNSDRGADCLPTSQTCFFQLRLPSYPSREVLAEKLRYAIYNCRSIDMDNYMLARNVEND 4833

HSP 2 Score: 179.874 bits (455), Expect = 7.142e-41
Identity = 124/376 (32.98%), Postives = 185/376 (49.20%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPT-LMNINGIQQIVCGSGVTLLITCESKLMACGEGL--EMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSI-EALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGE-PKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY----YPELVFFEKDIHLQQISCGRNHAAA 5572
            YIWG     +      +  + P    +     QI  G   +  I  E  + ACG+G    +       + T + +N     + KI  +S+SKG + H +A++  GE++SWG G +GKLGHG + T+K PK +   L GK       G+ HSA VT  G LY +G G  G+LG+    GC   +       E   +G VSCG +HT+A+S DG+ +++FG G  GKLG GD   ++ P L++ F    + KV CG   S ALT  G++Y WG     G+ L     D T     LV  L S       I+D+  G+    AL+++  +Y WG   NN +   G+ HA      P+ V   + +++ QIS G +H+ A
Sbjct:  364 YIWGSNSSHQLAEDRQEKILAPKQATSFTDCHQIEAGQFCSFGIHTEGSVSACGKGSYGRLGLGDSNNQTTPKKLNFE--PNRKIKKISSSKGSDGHTLAMSTDGEIYSWGDGDYGKLGHGSSCTVKYPKIVLGPLAGKIVKCVAAGYRHSAAVTEDGELYTWGEGDYGRLGH----GCSNSKSFPTRVTEISSVGQVSCGGSHTMAVSQDGKHIWSFGGGDNGKLGHGDTSKQYKPKLIEAFAGLYIRKVACGSQASMALTSTGQLYAWG----CGSCLGCGSEDFTALRPRLVEDLQSK-----RIVDISFGDSHCLALSHDSEVYAWG---NNAMGQCGQGHAQSPITRPKKVLGLEGVNVHQISAGTSHSVA 721

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
Match: V4BCY8 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_181433 PE=4 SV=1)

HSP 1 Score: 640.573 bits (1651), Expect = 0.000e+0
Identity = 507/1632 (31.07%), Postives = 761/1632 (46.63%), Query Frame = 2

Query: 2441 QIMELLAFGIISQNTVSKVKIWCLQNLMKMF----QLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLIS-VRNRQSILTADC--EGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHET----PVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSV-ILTDQICNKFFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKK--DKLTCV--LSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQ------------------FSDTGD--DVKNLI-----TFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNI----NNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNF-WSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKG---EAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGG-KAHAYYPELVFFEKDIHLQQISCGRNHAAA-SCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRIN----KKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYF----------HFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLD--EVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 7132
            Q++  L+  +IS    S  + W  Q L++      Q +QS++          VDL  DL     P     N  A   +L + + N +  L A    +GT+R+W++   I   Q L+QT +F           +R+     E                L  + + NI  + TG  LA S    +NIW+T    SK ++   S  +T L +PQ  + GL E     PVD +LV    G++ L+ + D+ S      ++      +++T  AW  E     IGY++G++ I +++  ++      H N IS L + P T H     L S++ ++  + IWK+  + L CV  L    P+T IEW       D    ++ +G   G I  W                   FS   D  D  NLI     T  GH+ SV  L    N  +L SGC  G VN+WSL D  L  T  G+G +  + W     +    SRS+ + I  +   N  + N I   A   +  L+S     +      +  +  L  LL EQ+  E  +V SG  +++SQYLQCL+     L+L  +L                           C+    L H        N+T+    +  WL      +K   A+      P + I       C   D  +++  +    +N  W+L Q  E+  W  + PE W     + +Y+WG G  G   E G S N     P+    +  QQIVCG   T +I     +MACGEG          ++ + +  +  L  + +T V+ S G + H +A+T  GEVFSWG G +GKLGHG++   K+P+ IEAL+G+  I    G+ HSAVVTA G L+ FG G  G+LG+   +    P  V   +   +IG+VSCG+NHTL +S DG  ++AFG+G YGKLG+G+      P  ++  Q  K+ KV CG  FS AL+  G VYTWG    +G   S +      +    V  LN  L     I D+  G + T ALT    ++ WGSN +  L LG   +    P  V   + +H+ QIS G+ H+AA +   P +               +PE    +Y++L   + N Y +  RL L+  +++L+  TW+      NQ+       L S   G+  +     ++ +L                     R  ++    +  M R I  +M+  +     + + R++    K  PV+IQT +QV+ +    LRLP RAWKVKL+ EGADDAGG +D+TI+E+C ELE+  I P +L P P+  +    N D  +    F           FLGIL   AIRTKKP+DLHL P  WK +    + V+D+  +D  Y  SL  +      G +  +  E   +D F   S +     +   GLK  +  NN  D+V+R + YRLHE D   E IR+    I P+ +L ++S   LE++VCG+  +SI++L+ + RY   + + I+  WFWE L +F   E+  FLRF++G++RLP++ + I  R  I  S +  NSLP SQTCF Q+RLP Y S+  +   LR AI+ CRSIDMD+YML RN EN +
Sbjct: 3236 QLINALSACVISARMSSNYRCWAAQQLVQALSAQGQRVQSDT-------DTQVDLSGDL-----PPCATTNLEAHQNRLSTCIWNSKKCLLASGGYDGTVRIWNM---ISKSQLLQQTCVF-----------NRDEGQTAED---------------LDGIPLNNICWNSTGKLLAASSDNMINIWATGG--SKGHLEIQSEWVTALAWPQ--TRGLFEGRLGLPVDCILVGSLDGKVALIDVVDSCSFYRKE-LEHCYRYNVSITQIAWYNEDKKFVIGYNDGTLSIASNKDYDQPINTEAHQNSISMLKWDP-TGHL----LLSTASNDQTVKIWKEGVEGLDCVAILPHQAPVTYIEWCPLLGHRDDKKLLLASGCEDGSIYLWTTPQPKTSNLTPSTIKTVGFSSPVDASDNSNLISKPIKTLLGHLTSVSCLTFSPNGLMLVSGCVKGLVNIWSLHDACLCQTYTGNGTIRSLCWFSDRMIAVCSSRSKDLTIIHFSPENYNRNNRIVSVA---RKSLKSRGLVGLHQAPCFRGLLQRLPDLLQEQYQHEKPMVFSGDQLMFSQYLQCLVTLVVGLSLDTAL---------------------------CYTPTPLHHQTGTTGRYNSTV---SEWQWLLNYSTAVKSCDALTKRSPFPQSFIN-----LCQNLDFISNNKEEILVSDNSKWNLIQDGEIMSWAINHPEDWQMGGLSESYLWGYGRHGQMCEGGQSCNKPVKVPSF---SCAQQIVCGQNCTFVIQFNGTIMACGEGSYGRLGQGNSDDLHTLTAIATLQGFVVTQVATSVGSDGHSLAVTESGEVFSWGDGDYGKLGHGNSDRQKRPRQIEALQGEEVIQLSTGYKHSAVVTADGKLFTFGNGDYGRLGHGSTANKKLPERVGELENY-QIGYVSCGLNHTLCVSVDGNNVWAFGDGDYGKLGLGNTTATAVPNKIEALQGVKIQKVACGNQFSVALSRCGSVYTWGLERLIGQANSSNRNPNKPQK---VSALNGHL-----ITDIAVGAEHTLALTVTGEVWAWGSNTDGQLGLGHINSPVKEPVCVPNLEGVHIIQISAGKTHSAAWTARPPPARTPGSLRPLLSLTLSLPEESPPQYSSL--KDINSYYIRGRLALLHQFSDLIYNTWRLLSLPKNQN------SLTSFETGAMGI-----IDGRL---------------------RSVLSPRVYTLPMVRSIGRTMVQGKNCGPHITVKRLSTRGKKCRPVYIQTAQQVVKLKPEELRLPARAWKVKLIGEGADDAGGVFDDTITEMCLELES-GIVP-LLLPTPNTKTETGNNRDRFLLNASFKAIEDHEVLYKFLGILFGVAIRTKKPLDLHLAPCVWKLLAGMTLQVEDIEEVDYLYIQSLRGILNIQENGVNETNFHEFIPIDSFEGQSSSGEMVPVIPGGLKIPLHFNNRKDYVDRVMQYRLHEMDRQAELIREGMSWIIPVPLLSLLSASALEQLVCGTAEVSINVLRQVVRYRGIEESHILIKWFWETLENFTNDERIQFLRFISGRTRLPTNPADISQRFQIMTSDRGLNSLPTSQTCFFQLRLPMYSSQEVLAEKLRYAINHCRSIDMDNYMLTRNTENGM 4730

HSP 2 Score: 181.8 bits (460), Expect = 1.936e-41
Identity = 121/375 (32.27%), Postives = 191/375 (50.93%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQQIVCGSGVTLLITCESKLMACGEGL--EMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY----YPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG     +    + +    P L +     QQI  G   T ++  +  + ACG+G    +       +   + I+     +  I  +S+SKG + H +A+T  GEVF+WG G +G+LGHG+ TT K PK ++AL GK       G+ HSAVVT  G LY +G G  G+LG+   +    P+LV D ++    +G V+CG ++T+A+S DG+ +++FG G  GKLG GD+  ++ P +++ F    + KV CG   S ALT  G+VY W                   E   L P L   L  +  I+D+  G+    AL+++  +Y WG+NA   +   G+ H+      P  VF  + + +QQIS G +H+ A
Sbjct:  381 FVWGSNSSHQLAEGSQEKIHTPKLASSFTDCQQIEAGQFCTFILMRDGSVSACGKGSYGRLGLGDSNNQAVPKTIHFEP--ERTIKKISSSKGSDGHTLALTHRGEVFTWGDGDYGRLGHGNNTTQKTPKLVQALLGKIVKSVSAGYRHSAVVTEDGELYTWGEGDYGRLGHGDSTSRGLPKLVKDISN----VGQVACGNSNTIAVSQDGKTVWSFGSGDNGKLGHGDMNRQYKPKVIEAFNGMCIRKVSCGSQTSLALTSTGQVYVW--------GSGSGLGCGLSEFTALTPQLVKDLHNV-HIVDIAMGDSHCIALSHDNRIYAWGNNA---MGQCGQGHSQSPLTRPRKVFGLEGVSIQQISAGTSHSVA 737

HSP 3 Score: 89.3521 bits (220), Expect = 1.649e-13
Identity = 73/271 (26.94%), Postives = 123/271 (45.39%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLK-VICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCH-LYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            +VF WG  S  +L  G    +  PK   +      I  + G   + ++   G +   G G  G+LG    +    P+ + F   EP     KI        HTLAL+  G+ ++ +G+G YG+LG G+   + +P LV     K++K V  G   SA +TE+GE+YTWG  D+         +   D +   +P L   +  +G    +  GN  T A++ +   ++ +GS  N  L  G     Y P+++     + ++++SCG   + A
Sbjct:  379 DVFVWGSNSSHQLAEGSQEKIHTPKLASSFTDCQQI--EAGQFCTFILMRDGSVSACGKGSYGRLGLGDSNNQAVPKTIHF---EPERTIKKISSSKGSDGHTLALTHRGE-VFTWGDGDYGRLGHGNNTTQKTPKLVQALLGKIVKSVSAGYRHSAVVTEDGELYTWGEGDY-------GRLGHGDSTSRGLPKLVKDISNVG---QVACGNSNTIAVSQDGKTVWSFGSGDNGKLGHGDMNRQYKPKVIEAFNGMCIRKVSCGSQTSLA 633

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
Match: A0A5G3L5I9 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 OS=Xenopus tropicalis OX=8364 GN=herc1 PE=4 SV=1)

HSP 1 Score: 630.558 bits (1625), Expect = 2.037e-179
Identity = 491/1681 (29.21%), Postives = 774/1681 (46.04%), Query Frame = 2

Query: 2312 DTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMEL---LAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQS----------ILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQ-ICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLT--CVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQF-----------SDTGDDVKNLITF-----------C-----GHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLI-STCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGI---CQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNL-----TGSLMPYYVMEPIDASNRNKSLWM-LEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            +  L+  P+ ++ Q L    + +L+     ++ +Y   + E    +EL   LA   +S    S+ + W  Q L++    + ++      A   + D+  DL            C+ T  KL + +NR +          + T+  +GT+R+W++     T+ +L+QT +F                  ME   + T+P             +  I  S +G YLA +L   +NIW       K  V +    ++ L +P++ S      + P + LLV    G L L+ + D  S+     ++     E+ VT  AW  E    A+GY +G +++ ++ I  K    +   H + I  + + P     G   L  +   E  + +W K  L+   +  L+ P  +    W S   +        + G  +GL+  W             S   DD K  I F           C     GH+  V  +    +   L SG   G +N+WSLKD S++ S   G G V    W P   +    +RS+ + +   F    L  N +   C+ A  ++  +    A        ++ F+  L  +L EQ+  E   V  G  +V+S Y+QCL      LNL        + P++   P D ++ N + W+ LE     CF   I          L    Q    FT+ ++            +P+              +E       SKW N         ++  W    PE W        ++WG G  G+   +  +  I     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVTA G L+ FG G  G+LG    S    P  V   +G   IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P L   L+GI FI D+  G + T AL+ +  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA   AP   R    + P      +P++   +Y+ L   +   + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  ++  E+  +D FV  S +     I   G    +  +N  ++V+R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+D+LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3301 ENKLVTSPNFVVTQAL----VALLADKGAKLRPNYDKAEMEKRGPLELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTAPQTLADMAGDLR----------KCSFT--KLEAHQNRVTASVWCSKKDLLATSGSDGTVRVWNVSR---TQYSLQQTCVFH----------------KMEGSTEETDP------------SLSLICWSVSGRYLAGALEKTINIWQVNG--GKGLVDAQPHWVSALTWPEENSGAAWTSDAP-ESLLVGRMDGSLGLIEVTDASSM-QRMELEHCYRKEVAVTCIAWYSEDRSFAVGYSDGKLLIGNRDIAEKAGIVIIDAHKDMIVSMKWDPT----GQMLL--TCAKEETVKLWGKSGLSWKTLYCLSHPSLVNTAAWCS---LVGNGERPQLMGCQSGLVCVWIIPQIPQEGVQPKSSASDDWKEQIPFQEMFRKVEYVRCVFKLRGHITPVRTVAFSHDGLALVSGGLGGLMNIWSLKDGSVLQSVVTGSGAVTTTVWIPDVGVAACSNRSKDVLVVN-FTPEWLSSNHVLATCRTALKQQGIVGLNMAPC------MQTFLERLPVMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLNLDRLLCNPPVPPHHYPSPPDPASWNPTEWVWLE-----CFSTTI-----KAAEALARGSQFPECFTVPDL----------EPVPE--------------EELKLVMDNSKWNNG-----TDEQIMSWATSKPEDWHLGGKCDVFLWGAGRHGQLAEAGRNVMIPSGAGSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTADGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGL-HIGQVACGLNHTLAVSADGSLVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQLVPVLLGI-FIDDIAVGAEHTLALSASGEVYAWGSNSEGQLGLGHTNHVREPTLVTALQGKNIRQISAGRCHSAAWTAAPVPPRAPGVAVPL--QLGLPDVIPPQYSCL--KDICLHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQSSASHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNATAEVGYNRDRFLLNPSSGLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEENFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVDRAIDYRLHEMDRQVAAVREGMSWIIPVPLLSLLTARQLEQMVCGMPEISVDVLKKVVRYREVDEQHQLVQWFWQTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPHDSLPTSQTCFFQLRLPPYSSQPVMAERLRYAINNCRSIDMDNYMLSRNVDN 4825

HSP 2 Score: 181.415 bits (459), Expect = 2.319e-41
Identity = 124/371 (33.42%), Postives = 185/371 (49.87%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHA-YYPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L    +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +V+  +    + +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     + +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFTRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGVAIQQISAGTSHSLA 732

HSP 3 Score: 88.5817 bits (218), Expect = 3.230e-13
Identity = 85/319 (26.65%), Postives = 136/319 (42.63%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK         +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ F   +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGM-FTRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
Match: A0A5G3L226 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 OS=Xenopus tropicalis OX=8364 GN=herc1 PE=4 SV=1)

HSP 1 Score: 619.002 bits (1595), Expect = 8.719e-176
Identity = 481/1634 (29.44%), Postives = 751/1634 (45.96%), Query Frame = 2

Query: 2441 QIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQS----------ILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQ-ICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLT--CVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQF-----------SDTGDD---------------VKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLI-STCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGI---CQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLM-----PYYVMEPIDASNRNKSLWM-LEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            ++   LA   +S    S+ + W  Q L++    + ++      A   + D+  DL            C+ T  KL + +NR +          + T+  +GT+R+W++     T+ +L+QT +F                    K    TE     LS          I  S +G YLA +L   +NIW       K  V +    ++ L +P++ S      + P + LLV    G L L+ + D  S+     ++     E+ VT  AW  E    A+GY +G +++ ++ I  K    +   H + I  + + P     G   L  +   E  + +W K  L+   +  L+ P  +    W S   +        + G  +GL+  W             S   DD               V+ +    GH+  V  +    +   L SG   G +N+WSLKD S++ S   G G V    W P   +    +RS+ + +   F    L  N +   C+ A  ++  +    A        ++ F+  L  +L EQ+  E   V  G  +V+S Y+QCL      LNL   L      P++   P D ++ N + W+ LE     CF   I          L    Q    FT+ ++            +P+              +E       SKW N         ++  W    PE W        ++WG G  G+   +  +  I     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVTA G L+ FG G  G+LG    S    P  V   +G   IG V+CG+NHTLA+S DG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P L   L+GI FI D+  G + T AL+ +  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA   AP   R    + P      +P++   +Y+ L   +   + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  ++  E+  +D FV  S +     I   G    +  +N  ++V+R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+D+LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3331 ELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTAPQTLADMAGDLR----------KCSFT--KLEAHQNRVTASVWCSKKDLLATSGSDGTVRVWNVSR---TQYSLQQTCVF-------------------HKMCGSTEETDPSLSL---------ICWSVSGRYLAGALEKTINIWQVNG--GKGLVDAQPHWVSALTWPEENSGAAWTSDAP-ESLLVGRMDGSLGLIEVTDASSM-QRMELEHCYRKEVAVTCIAWYSEDRSFAVGYSDGKLLIGNRDIAEKAGIVIIDAHKDMIVSMKWDPT----GQMLL--TCAKEETVKLWGKSGLSWKTLYCLSHPSLVNTAAWCS---LVGNGERPQLMGCQSGLVCVWIIPQIPQEGVQPKSSASDDWKEQAISKVREKVEYVRCVFKLRGHITPVRTVAFSHDGLALVSGGLGGLMNIWSLKDGSVLQSVVTGSGAVTTTVWIPDVGVAACSNRSKDVLVVN-FTPEWLSSNHVLATCRTALKQQGIVGLNMAPC------MQTFLERLPVMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLNLDRLLCNPPVPPHHYPSPPDPASWNPTEWVWLE-----CFSTTI-----KAAEALARGSQFPECFTVPDL----------EPVPE--------------EELKLVMDNSKWNNG-----TDEQIMSWATSKPEDWHLGGKCDVFLWGAGRHGQLAEAGRNVMIPSGAGSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTADGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGL-HIGQVACGLNHTLAVSADGSLVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQLVPVLLGI-FIDDIAVGAEHTLALSASGEVYAWGSNSEGQLGLGHTNHVREPTLVTALQGKNIRQISAGRCHSAAWTAAPVPPRAPGVAVPL--QLGLPDVIPPQYSCL--KDICLHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQSSASHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNATAEVGYNRDRFLLNPSSGLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEENFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVDRAIDYRLHEMDRQVAAVREGMSWIIPVPLLSLLTARQLEQMVCGMPEISVDVLKKVVRYREVDEQHQLVQWFWQTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPHDSLPTSQTCFFQLRLPPYSSQPVMAERLRYAINNCRSIDMDNYMLSRNVDN 4812

HSP 2 Score: 180.644 bits (457), Expect = 4.066e-41
Identity = 124/371 (33.42%), Postives = 185/371 (49.87%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY-YPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L    +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +V+  +    + +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     + +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFTRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGVAIQQISAGTSHSLA 732

HSP 3 Score: 88.1965 bits (217), Expect = 3.916e-13
Identity = 85/319 (26.65%), Postives = 136/319 (42.63%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK         +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ F   +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPCFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGM-FTRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
Match: A0A2K6EJT9 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 OS=Propithecus coquereli OX=379532 GN=HERC1 PE=4 SV=1)

HSP 1 Score: 615.92 bits (1587), Expect = 9.192e-175
Identity = 481/1677 (28.68%), Postives = 755/1677 (45.02%), Query Frame = 2

Query: 2321 LLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMEL---LAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGL--HETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVIL-TDQICNK--FFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLT--CVLSLNEP--ITCIEWLSRKYINDKNHHVIIAGLSTGLIQFW-------------------QFSDTGDD------VKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCN-GDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNL------KNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQ-------------LHWLFTIDEVMKLTQAICFERDIPDNI-IPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK----EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST-------FIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            L+  P+ ++ Q L    + +L+     ++ +Y   + E +  +EL   LA   +S    S+ + W  Q L++    + ++          + D+  DL       I L      V   +    +  + T+  +GT+R+W++      + +L+QT +F           +R      E     ++P                ++ S +G YLA +L   +NIW       K  V      ++ L +P++        E+P +LLLV    G L L+ + D  S +    ++     +++VT  AW  E    A+GY +G ++L T +   K    L   H + I  + + P T H   T        E N+ +W        C+ SL  P  +  I W S      K   ++  G  +GL+  W                   Q S+  D        K +    GH+  V  +    +   L SG   G +N+WSL+D S++ T   G G +    W P+  +    +RS+          + L  N   +WA    +      A   + +  L      + F+  L  +L EQ+  E   V  G  +V+S Y+QCL      L+L                                         L  N  +PP+HQ               WL      +K  +A+      P++  +P    +  V  DE       SKW N         ++  W    PE W        Y+WG G  G+   +  +  +     + +  QQ++CG   T +I     ++ACGEG          ++ + +  +  L  + +T +  S G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEAL+G+  +   CG  HSAVVT+ G L+ FG G  G+LG    S    P  V   +G  +IG V+CG+NHTLA+STDG  ++AFG+G YGKLG+G+   + SP  VD      + KV CG  FS ALT++G VYT+G    +G  L +      +      P     L G+  I D+  G + T AL +N  +Y WGSN+   L LG   H   P LV   +  +++QIS GR H+AA    P   R    S P      +P+    +Y  L   E + + + ARL L+ ++++L+  +W+      N     S Y+  +                           W         ++R  +     +  M R I  +M+  + Y   + + RI+ +    +P+F+Q  RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   +L P P+ T+        F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E + +  +S  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ + LE++VCG   IS+++LK + RY + D    +  WFW  L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN +N
Sbjct: 3311 LVTSPNFVVTQAL----VALLADKGAKLRPNYDKTEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRT---LAAHDRDNQTTLQTLADMGGDL--RKCSFIKLEAHQNRVMTCVWCNKKGLLATSGTDGTIRVWNVTK---KQYSLQQTCVF-----------NRLEGDAEESLGSPSDP------------SFSPVSWSISGKYLAGALEKMVNIWQVNG--GKGLVDIQPHWVSALAWPEEGPAAAWSGESP-ELLLVGRMDGSLGLIEVVDV-STMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTIVSMKWDP-TGHILMT-----CAKEENVKLWGPVSGCWCCLQSLCHPSIVNGIAWCSLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTSVTSSEGWWDQESNCQDGYRKSTGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSK----------DVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHL---------------------------------------DQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPD---LEPVPEDELVFLMDNSKWINGM-----DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVACGLNHTLAVSTDGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG--LPEGRARNHNR-----PQQIPVLAGV-VIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL--QLGLPDAVPPQYGVLR--EVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGT---------------------------WGIVQG----QLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVV--DLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHI-EDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLIMAERLRYAINNCRSIDMDNYMLSRNVDN 4838

HSP 2 Score: 182.57 bits (462), Expect = 1.054e-41
Identity = 124/371 (33.42%), Postives = 187/371 (50.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLM-NINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAY-YPELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    T +  ++P L  + +  Q I  G   T +I+ +  + ACG+G               +  +       I  VS+SKG + H +A T  GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G VSCG +HT+ALS DG+ +++FG G  GKLG GD    + P +++  +   ++ +C G   S ALT  G+VY WG    +G   S        E+  L P L   L     I+D+  G+    AL+++  +Y WG+N+      G        P+ V     I +QQIS G +H+ A
Sbjct:  375 YVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS--------EATALRPKLIEELAAT-RIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732

HSP 3 Score: 90.5077 bits (223), Expect = 7.450e-14
Identity = 86/319 (26.96%), Postives = 138/319 (43.26%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEP-----KIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF------------VGTFLSD--------------------------------SEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG-GKAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            EV+ WG  S  +L  G    + +PK   +     +I  + G   + V++  G +   G G  G+LG    +   T + + F   EP     K+        HTLA +T+G+ ++++G+G YGKLG G+   +  P L+    Q K ++ V  G   SAA+TE+GE+YTWG  DF            + T + D                                 ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   +Y WG  A   L  G  +A A  P+L+       +  IS G +H  A  H
Sbjct:  373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTF---EPHRSIKKVSSSKGSDGHTLAFTTEGE-VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGM-FIRKVCAGSQSSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLALSH 682

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
Match: herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-070718-6])

HSP 1 Score: 355.91 bits (912), Expect = 1.038e-97
Identity = 270/946 (28.54%), Postives = 430/946 (45.45%), Query Frame = 2

Query: 4382 NNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIP--PQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            +  +  +   +L QW    P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+ +   +P+ IE+LRG   +    G  HSA +TASG LY +G G  G+LG+        P+LVD   G  ++  V+CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYTWG  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EIP++         ++  ++    I +           +  + QT Q            S+G  +L                           IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    P     F FLG+L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA++  F+++   + V    C    +  ++  H      + + N +++V   I YRLHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3917 HELFKREHDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPTEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIRKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGVEVVDIAAGGAHSACITASGELYTWGKGRYGRLGHGDSEDQLKPKLVDALQGH-RVIDVACGSGDAQTLCL-TDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSAHTLAWSTSKPTNAGKLPAQVPMEYNHLQEIPIMALRNRLLLLHHISELFCPCIPM--------FDLEGRLGQTGQ----------GPSVGFDTL-----------------------RGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKSPLHMSMFRFLGVLLGIAIRTGSPLSLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEFEAMPLPFTVPN-ACGQEVQLSSKYSH------ISLENRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGVEPTAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVVQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKLVLEEKLKYAIHFCKSIDTDDYARI 4794

HSP 2 Score: 150.599 bits (379), Expect = 1.810e-35
Identity = 117/374 (31.28%), Postives = 181/374 (48.40%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N + Q+  GS     +T E K+ ACGE         +   T  I   V  L++Y +  V+   G   H +A+T+ G+VFSWG G  GKLGH       KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P+LV    G  ++  V+CG     TLAL+ +G  ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+TWG  D+   F      D+    H+  P +   L G   I+ +  G     A+T    ++ WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2955 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-VVQVSGGSKSLFAVTAEGKVYACGEATNGRLGLGLSSGTIPIPRQVSALSNYVVKKVAVHSGGR-HAMALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGH-RVIQVACGSRDAQTLALTDEGL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY---FRLGHGTDV----HVRKPQMVEGLRG-KKIVHVAVGALHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3316

HSP 3 Score: 149.058 bits (375), Expect = 4.994e-35
Identity = 110/334 (32.93%), Postives = 170/334 (50.90%), Query Frame = 2

Query: 4478 IWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPES-HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSN 5455
            + G G+ G   ++  +  I+   ++  G+ QIVC     L+++              ++    +  T   + V  L+  KI  ++A   PE  H +A++  GEVFSWG G  G+LGHG  T L++P  I A  GK      +   CG  +SA +TA G L+ +G G  G+LG+       TP LV    G  K+  V+CG     TL+++ +GQ ++++G+G YGKLG G      SP LV+  Q   ++KV CG  FS ALT++G+VYTWG  D       +  +    + H+  P L  SL G   ++D+  G+    ALT +  ++ WGSN
Sbjct:  424 VIGWGLLGWKVYANVNGPIQCKALSSLGVTQIVCSEKGFLILSISGA----------VYTQNYKSTTLSPMLVHGLSSRKIVKLAAH--PEGQHYLALSANGEVFSWGCGDGGRLGHGDTTYLEEPTMIAAFSGKQVGKHVVHIACGSTYSAAITADGELFTWGRGNYGRLGHGSSEDQTTPMLVTALKGL-KVIDVACGSGDAQTLSVTENGQ-VWSWGDGDYGKLGRGGSDGCKSPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGD-------NQRLGHGTDEHVRYPKLLDSLQG-KKVVDIAVGSTHCLALTEDGEVHSWGSN 735

HSP 4 Score: 105.531 bits (262), Expect = 7.405e-22
Identity = 97/335 (28.96%), Postives = 144/335 (42.99%), Query Frame = 2

Query: 4607 CESKLMACG-EGLEMIFNPFMREETYRIINVPVL--------NDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGC-DTPRLVD-FTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            C S  + C   GL ++    +R E   +  VP L        +D   T   A K       A +I  +VF WG+    +LG    + +K P   E L     +    G      VTA G +Y  G   NG+LG  + SG    PR V   ++   K   V  G  H +AL+ DG K++++GEG  GKLG     +   P L++  + K++  + CG S SAA+T +GE+Y+WG  ++         +   D +  L P L   L+G   I   C   D  T ALT+   ++ WG      L  GG      P+ +       + QI CG   + A
Sbjct: 2888 CRSSGIDCKIHGLSIVGR--IRAEDEDLATVPFLASDNEEEEDDKAATGSLARKRSSGLESAASIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVSGGSKSLFAVTAEGKVYACGEATNGRLGLGLSSGTIPIPRQVSALSNYVVKKVAVHSGGRHAMALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEY-------GRLGHGDNTTQLRPKLVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLA 3212

HSP 5 Score: 94.7449 bits (234), Expect = 1.564e-18
Identity = 65/231 (28.14%), Postives = 105/231 (45.45%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQ-------IVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + +   Y     +   + WGCG  G  G        +PT++     +Q       I CGS  +  IT + +L   G G          E+    + V  L   K+  V+   G ++  +++T  G+V+SWG G +GKLG G +   K PK +E L+    +   CG   S  +T  G +Y +G G N +LG+        P+L+D   G+ K+  ++ G  H LAL+ DG+
Sbjct:  500 HPEGQHYLALSANGEVFSWGCGDGGRLGHGDTTYLEEPTMIAAFSGKQVGKHVVHIACGSTYSAAITADGELFTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSG-DAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKSPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGK-KVVDIAVGSTHCLALTEDGE 728

HSP 6 Score: 63.1586 bits (152), Expect = 5.686e-9
Identity = 53/210 (25.24%), Postives = 96/210 (45.71%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQ--QIVCGSG--VTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            + WG G  G  G  +++D   P L+  + G++   + CGSG   TL +T   ++ + G+G          +       V  L D  I  V          +A+T  G+V++WG G + +LGHG    ++ PK +++L+GK  +    G  H   +T  G ++ +G     Q  + + S    P+ +   + +  +G +SCG   + A S+
Sbjct:  572 FTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKSPKLVEKLQDLDIVKVCCGS---QFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGKKVVDIAVGSTHCLALTEDGEVHSWGSNDKLQHFDTLFSNKKQPKALPGLNSKHIVG-ISCGPGQSFAWSS 777

HSP 7 Score: 60.8474 bits (146), Expect = 2.819e-8
Identity = 44/154 (28.57%), Postives = 67/154 (43.51%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVT 4927
            + WG G  G+ G   ++    P     +N  G+ QI CG+  +L +T    +   G+G              +   V  L   KI HV+       H +A+T  G+VF+WG   HG+ G+G  T  +KP  ++ L G+      CG  HS   T
Sbjct: 3168 FSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQMVEGLRGKKIVHVAVGA---LHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3318

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
Match: ENSAMXT00000014806.2 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000133.1:558903:571495:-1 gene:ENSAMXG00000014386.2 transcript:ENSAMXT00000014806.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 284.263 bits (726), Expect = 1.944e-82
Identity = 154/360 (42.78%), Postives = 221/360 (61.39%), Query Frame = 2

Query: 6077 RQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPS-----DTSTFIPNPDPTIPPQY--FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSY---FNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            RQV+ ++A  LRLP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   I +P+P+     +   F+ NP   +      F FLGILM  AIRTKKP+DLHL P+ WK++    ++++DL  +D  Y    NS+L + E  S+   +  E+  +D FV  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   IS+++LK + RY + +    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I    +P +SLP SQTCF Q+RLP Y S+S M   LR AI+ CRSIDMD+YML RN +N
Sbjct:  190 RQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPMPTAEVGYNRDRFLLNPSACLEEHLLQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHL-EDTSITEQNFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEIDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGLPEISVEVLKKVVRYREVEEQQQLVQWFWQTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIM---KPYDSLPTSQTCFFQLRLPPYSSQSLMAERLRYAINNCRSIDMDNYMLSRNVDN 545

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
Match: ENSAMXT00000042389.1 (pep primary_assembly:Astyanax_mexicanus-2.0:14:34361486:34364822:-1 gene:ENSAMXG00000041031.1 transcript:ENSAMXT00000042389.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 144.821 bits (364), Expect = 3.238e-38
Identity = 75/211 (35.55%), Postives = 120/211 (56.87%), Query Frame = 2

Query: 6308 FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMN--EAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHI 6934
            F FLGILMA A+RTKKP+DLHL P  WK++    +   DL  +D   + SL  +   + +S+  ++   +  +D FV  S       +   G    +   N +++V R + YRLHE D  +  +R+   +I P+ +L +++ R LE++VCG   +S+++LK + RY D   +  +  W W+ L  F   E+ LFLRFV+G+SRLPS+ + I
Sbjct:    4 FRFLGILMAVAVRTKKPLDLHLAPWVWKQLCCIPLGGADLEEVDLLTYRSLQGILHLDDSSINEENFTVMIPLDSFVAHSAEGKLVPVVPGGHNLPLTFTNRNEYVERALEYRLHEMDRQVAAVREGMSSIIPVPLLSLLTARQLEQLVCGLPEVSVEMLKKVVRYRDITESHQLIVWLWQSLEEFTNEERVLFLRFVSGRSRLPSNPADI 214

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
Match: hectd3 (HECT domain E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:103042680])

HSP 1 Score: 142.124 bits (357), Expect = 2.094e-33
Identity = 99/339 (29.20%), Postives = 162/339 (47.79%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNEL---ENEAIFP-----RILTPIPSDTSTF-IPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMT-KSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTE---TEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPA---NSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W+ K + EG  D GG + ++++++  EL     E   P     R    +  +   F +PNP      Q + ++G LM  A+R K  + L L  + WK++T +SI   +D   +D      L +M       FD     +   + + +S   ++    E+   G    V   +  +FV      RL E    I  I+     + P  +LD+++W+ +EK VCG   I+++ LK + RY D +  D+     WE L +F   ++S FLRFVTG+SRLP+        ++++  KQ +   ++LPQS TC + + LP+Y S    E  LR A   C +ID D
Sbjct:  524 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSAECAMPLPFFTRTSNQVAGEARDFYVPNPS-CREFQKYEWIGQLMGAALRGKDFLVLALPGLVWKQLTGESISWNEDFPAVDSVLVKLLEAMERMDKETFD-----FKFGQELVYSTPLSDGRLVELIPGGGSVVVRYEDRMEFVRLVQKSRLEESKEQIAAIQAGLMKVVPQAVLDLLTWQEVEKKVCGDPEITVEALKRLTRYEDLEQTDVRVQHLWEALTNFTNEDRSRFLRFVTGRSRLPAP-------IYVFPDKQGSETTDALPQSSTCSSTLYLPKYPSAKVCEEKLRYAAYNCVAIDTD 849

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
Match: SMURF2 (SMAD specific E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:103046280])

HSP 1 Score: 120.939 bits (302), Expect = 5.233e-27
Identity = 93/352 (26.42%), Postives = 160/352 (45.45%), Query Frame = 2

Query: 6050 KEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYR-LHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP------SHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQ 7075
            +E +F ++ RQV+ M    L   W+   VK   E   D GG   E +  + +E+ N   +  +      D  T   NPD  + P+   YFHF+G +M  A+     ID      F+K++    ++++D+  +DP   NSL+ + E    G   LD  + V+      +   + E+   G    V      ++V   + +R LH  ++    ++K F  + P  +L     + LE IVCG   I I   +   R      +  +  WFW+ + +F+E  ++  L+FVTG SR+P         +  P +  I+      N+LP++ TCFN++ +P Y+S   +   L  AI +
Sbjct:  385 REEIFEESYRQVMKMRQKDL---WKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNP--YYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLEDMESVDPDLHNSLVWILENDITGV--LDHTFCVEHSAYGQI--IQHELKPNGKTIPVSEETKKEYVRLYVNWRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIHDWRANTRLKHCTADSNVVKWFWKAVETFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRQFTIHQIDASTNNLPKAHTCFNRVDIPPYESYDKLYDKLLTAIEE 727

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001275.1 (pep scaffold:Pmarinus_7.0:GL476529:184068:212443:-1 gene:ENSPMAG00000001140.1 transcript:ENSPMAT00000001275.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 176.022 bits (445), Expect = 3.063e-44
Identity = 124/388 (31.96%), Postives = 196/388 (50.52%), Query Frame = 2

Query: 4433 DSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMN-INGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEA-LRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLV-DFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVIC-GKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHA----YYPELVFFEKDIHLQQISCGRNHAAA 5572
            DSP   +SE S   Y+WG     +      +  ++P + +     Q I  G   T +I  +  + ACG+G               +  +       +  +S+S+G + H +A+T+ GEVFSWG G +GKLGHG+++T K PK I+  L+GK  +    G+ HSA VT  G LY +G G  G+LG+   +  + P LV D ++    +G V+CG +HT+A+S DG+ +++FG G  GKLG GD    + P +++  +   ++ +C G   S ALT  G++Y WG    +G          + E+  L P L   L     I+D+  G+    ALT++  +Y WG   NN +   G+ H+      P+ V     I +QQIS G +H+ A
Sbjct:  371 DSP--VVSETSE-VYVWGSNSSHQLAEGAQEKILQPKMASGFANAQTIEAGQYCTFVIAVDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPQRAVKKISSSRGSDGHTLAVTMEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN----VGQVACGSSHTIAVSQDGRIVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQLYAWGCGACLGCG--------SSEATALRPKLIEDLA-CTRIVDISCGDSHCLALTHDNEVYAWG---NNSMGQCGQGHSTSPVTKPKKVMGMDGISVQQISAGTSHSLA 739

HSP 2 Score: 107.457 bits (267), Expect = 2.871e-23
Identity = 91/278 (32.73%), Postives = 143/278 (51.44%), Query Frame = 2

Query: 4766 ITIFGEVFSWGIGSHGKLGHGHA---TTLKKPKSIEALRGKGSIMSDCGH-MHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGE-VYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGG-KAHAYYPELVFFEKDIHLQQISCGRNHAAASCH 5581
            I + G V + G GS+G+LG G +   +TLKK  + E  R    I S  G   H+  VT  G ++ +G G  G+LG+   S    P+L+        +  VS G  H+ +++ DG+ LY +GEG +G+LG GD   R  PTLV      + +V CG S + A++++G  V+++G  D       + ++   D + +  P +  +L G+ FI  +CAG+ ++ ALT+   LY WG  A   L  G  +A A  P+L+       +  ISCG +H  A  H
Sbjct:  425 IAVDGSVRACGKGSYGRLGLGDSNNQSTLKK-LTFEPQRAVKKISSSRGSDGHTLAVTMEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGE-LYTWGEGDFGRLGHGDSNSRNIPTLVK-DISNVGQVACGSSHTIAVSQDGRIVWSFGGGD-------NGKLGHGDTNRVYKPKVIEALQGM-FIRKVCAGSQSSLALTSTGQLYAWGCGA--CLGCGSSEATALRPKLIEDLACTRIVDISCGDSHCLALTH 689

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005516.1 (pep scaffold:Pmarinus_7.0:GL477585:22018:44632:1 gene:ENSPMAG00000004971.1 transcript:ENSPMAT00000005516.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.775 bits (286), Expect = 1.043e-25
Identity = 91/339 (26.84%), Postives = 155/339 (45.72%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIP------------SDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTET-EICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANS---LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W      EG +DAGG   E +S+I  EL      P    P+P             ++  ++PNPD       F ++G +M  A+R    + L L  + WK++    V+  D   +D +   SL S+ EAA     +  +++G +     +++   T E+   G+  +V   +   +       RL E    +E IRK   ++ P  ++++++W+ +E+IV G   I++D+LK     V  D  +      +E L +F+  ++ LFLRFVTG+SR        P  + +  S   +N    LP++  C N + LP Y S    E  L  A+  C ++D D
Sbjct:  513 WSCDFTLEGMNDAGGGQRECLSDIAEELCPSD--PYCPVPVPFFLRMLGRSTGGQESCVYVPNPD-CRDLYMFTWIGKIMGAALRGANILILCLPALVWKQLVGETVTWSDFRSVDETLARSLRSLEEAADE--AAFAQLFGEELTYATTLSSGRTVELVPGGVWVRVHYGDRLRYARLVQEARLCESRQQVEAIRKGIFSVVPQHIVNLLTWQEMERIVSGEAEITMDVLKRSITSV-MDNGEARMKCLFEALSNFSNEDRRLFLRFVTGRSR-------PPITIQVMQSSMDSNKSDVLPETSLCSNTLILPNYSSAKVCEEKLHFAMYNCTTVDRD 838

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
Match: smurf2 (SMAD specific E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:563633])

HSP 1 Score: 93.9745 bits (232), Expect = 2.853e-19
Identity = 86/335 (25.67%), Postives = 149/335 (44.48%), Query Frame = 2

Query: 6059 VFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL---LSMNEAASLGFDSLDEVYGVDKFVCF-SVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPR 7024
            +F ++ RQV+ M    L+   +   VK   E   D GG   E +  + +E+ N   +  +      D  T   NPD  I P+   YFHF+G +M  A+     ID      F+K++    +++ D+  +DP    SL   L+ ++   L   ++   +G     CF +VNK        G+   + +     +V+   +  L   ++    ++K F  + P  +L     + LE I+ G   I +   K+  R         +  WFW  + SF+E  ++  L+FVTG SR+P     +       RLF I++     ++LP++ TCFN+I + R
Sbjct:  411 IFEESYRQVMKMRPRDLK---KRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNP--YYGLFQYSRDDIYTLQINPDSAINPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLADMETVDPELHKSLVWILNNSDVNILHEHTVHSCWGGRVQFCFRTVNK--------GVPAMIRLAPRRLYVS---WRFLRGIEAQFLALQKGFNELIPQPLLKSFDEKELELIIGGLGKIDVSDWKSNTRLKHCTPESSVVRWFWRAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHLIDAKTDNLPKAHTCFNRIDITR 729

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
Match: nedd4a (NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-051005-2])

HSP 1 Score: 90.8929 bits (224), Expect = 1.154e-18
Identity = 87/353 (24.65%), Postives = 155/353 (43.91%), Query Frame = 2

Query: 6077 RQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ----YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHE-FDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDAD-INDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPS------HDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDD 7099
            R+++ +    L L  R W ++   E   D GG   E    I  E+ N   +  +     +D  T   NP   +  +    YF F+G +   A+   K +D      F+K M +  ++++D+  +D  Y+NSL+ + E        LD  + +D+   F       E+   G +  V   N  +++   I +R  E     I    + F  + PM ++ I     LE ++CG   + ++  +    Y ++   N  +  WFW+ +   +  ++   L+FVTG SR+P       + S+ P +LF       +  LP++ TCFN++ LP Y+S  D+   L IAI   +  +  D
Sbjct:  151 RRIVAVKRADL-LKARLW-IEFDGEKGLDYGGVAREWFFLISKEMFNP--YYGLFEYSATDNYTLQINPISGLCNEEHLSYFTFIGRVAGMAVFHGKLLDGFFIRPFYKMMLQKPITLNDMESVDSEYYNSLMWILENDPA---DLDLRFCIDE-EMFGQQTHLVELKPNGSEILVTNENKKEYIELVIQWRFVERVQKQINAFMEGFSELIPMDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNSYCANHPVIQWFWKAVLLMDGEKRIRLLQFVTGTSRVPMNGFAELYGSNGP-QLFTIEMWSTSEKLPRAHTCFNRLDLPPYESFDDLREKLNIAIENAQGFEGVD 494

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
Match: NEK9 (NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC:18591])

HSP 1 Score: 90.5077 bits (223), Expect = 3.136e-18
Identity = 81/277 (29.24%), Postives = 128/277 (46.21%), Query Frame = 2

Query: 4712 YKITHVSASKGPESHIIAITIFGEVFSW-----GIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFG------LGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKK-KLLKVICGKSFSAALTENGEVYTWGHSDF-------VGTFLSDSEVDLTDESHL-LVPTLNSSLVGIGFIIDLCAGNDTTFALTNNC-HLYGWGSNANNLLRLG 5479
            Y    V AS    +H  A+T+  E+++W     G    G+LGH    + ++PK ++ L G       CG   +  +T  G ++ FG      +G NG+LG E+L     P  V F +  P +  +SCG  H +AL+  G  +YA+G G YG+LG+      F P  V    + K+ +V CG   +  LT  G+V   G+++F         + L + E  +  E  + L+PTL   L    + I   +G  T  A+ + C  L  +G N +  L  G
Sbjct:  350 YSALRVCASN---THFAAVTVEKELYTWANVQGGTKMVGQLGHKDKASYRQPKRVDKLLGLAVRQVACGDEFTVCLTEQGEVFSFGSDYYGCMGCNGELGVEVLE----PMPVQFFNINP-VTQISCGDCHVMALTRSG-AVYAWGCGEYGRLGLETDATEFYPKRVPLSNRWKITEVCCGTDGTFFLTAQGKVLACGNNEFNKLGLNQCTSGLRNRETSVFHEVIMKLMPTLVKQLS--IYKIRSISGGKTHSAVIDVCGRLLTFGHNKHGQLGTG 615

HSP 2 Score: 67.781 bits (164), Expect = 3.265e-11
Identity = 69/260 (26.54%), Postives = 110/260 (42.31%), Query Frame = 2

Query: 4559 GIQQIVCGSGVTLLITCESKLMACGEGLE--MIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSD-CGHMHSAVVTASGGLYMFGLGVNGQLG-NEILSGCDTPRLVDFTD-------------GEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD--FQKKKLLKVICGKSFSAALTE-NGEVYTWGHSD 5278
             ++Q+ CG   T+ +T + ++ + G      M  N  +  E    + V   N   +T +S     + H++A+T  G V++WG G +G+LG     T   PK +  L  +  I    CG   +  +TA G +   G     +LG N+  SG        F +                KI  +S G  H+  +   G +L  FG   +G+LG GD K      L       K +  V CG  F+ A TE +  +Y WG++D
Sbjct:  408 AVRQVACGDEFTVCLTEQGEVFSFGSDYYGCMGCNGELGVEVLEPMPVQFFNINPVTQISCG---DCHVMALTRSGAVYAWGCGEYGRLGLETDATEFYPKRV-PLSNRWKITEVCCGTDGTFFLTAQGKVLACGNNEFNKLGLNQCTSGLRNRETSVFHEVIMKLMPTLVKQLSIYKIRSISGGKTHSAVIDVCG-RLLTFGHNKHGQLGTGDFKKHLGIVLHKGPLVGKLITMVSCGDGFTIAATEADNHIYAWGNTD 662

HSP 3 Score: 67.781 bits (164), Expect = 3.265e-11
Identity = 72/262 (27.48%), Postives = 110/262 (41.98%), Query Frame = 2

Query: 4760 IAITIFGEVFSWG------IGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVG---------------DVKDRFSPTLV-DFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLG 5479
            + +T  GEVFS+G      +G +G+LG      + +P  ++           CG  H   +T SG +Y +G G  G+LG E  +    P+ V  ++   KI  V CG + T  L+  G K+ A G   + KLG+                +V  +  PTLV      K+  +  GK+ SA +   G + T+GH+        D +       HL +      LVG    +  C    T  A   + H+Y WG+  N   RLG
Sbjct:  420 VCLTEQGEVFSFGSDYYGCMGCNGELG----VEVLEPMPVQFFNINPVTQISCGDCHVMALTRSGAVYAWGCGEYGRLGLETDATEFYPKRVPLSN-RWKITEVCCGTDGTFFLTAQG-KVLACGNNEFNKLGLNQCTSGLRNRETSVFHEVIMKLMPTLVKQLSIYKIRSISGGKTHSAVIDVCGRLLTFGHNKHGQLGTGDFK------KHLGIVLHKGPLVGKLITMVSCGDGFTIAATEADNHIYAWGNTDNG--RLG 667

HSP 4 Score: 55.8398 bits (133), Expect = 1.217e-7
Identity = 76/259 (29.34%), Postives = 101/259 (39.00%), Query Frame = 2

Query: 4460 YSNSTYIWGC-GIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMA--CGE----GLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHAT--------------------TLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIG----FVSCGMNHTLALSTDGQKLYAFGEGVYGKLGV 5143
            +S  +  +GC G  GE G    +  +     NIN + QI CG    + +T    + A  CGE    GLE     F  +       VP+ N +KIT V            +T  G+V + G     KLG    T                    TL K  SI  +R   SI    G  HSAV+   G L  FG   +GQLG    +G     L       P +G     VSCG   T+A +     +YA+G    G+LGV
Sbjct:  429 FSFGSDYYGCMGCNGELGVEVLEP-MPVQFFNINPVTQISCGDCHVMALTRSGAVYAWGCGEYGRLGLETDATEFYPK------RVPLSNRWKITEVCCGT---DGTFFLTAQGKVLACGNNEFNKLGLNQCTSGLRNRETSVFHEVIMKLMPTLVKQLSIYKIR---SISG--GKTHSAVIDVCGRLLTFGHNKHGQLG----TGDFKKHLGIVLHKGPLVGKLITMVSCGDGFTIAATEADNHIYAWGNTDNGRLGV 668

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
Match: TOM1 (E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865])

HSP 1 Score: 110.153 bits (274), Expect = 4.142e-24
Identity = 91/360 (25.28%), Postives = 160/360 (44.44%), Query Frame = 2

Query: 6047 KKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENE--AIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLL-----SMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLH-EFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSH------DSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQ 7075
            ++E VF+ + R +      +  +     ++    E   DAGG   E    +  ++ N   A+F     P+PSD +TF PN    I P+   +F F+G+++  AIR +  +D H     +K +    VS+ D+  +DP Y+ SL+      + +     F    + YG  K +          +   G    V   N  D+V + + Y+L       +++    F  +    ++ I   + LE ++ G   I +D  KN   YV+        S+FW  + SF+  E++  L+FVTG S++P +        +   +  I+     +  LP S TCFNQ+ LP Y+S   +   L +AI++
Sbjct: 2916 RREQVFLDSYRALFF--KTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALF----LPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILENDITDIIEETFSVETDDYGEHKVI---------NLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINE 3260

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
Match: RSP5 (NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927])

HSP 1 Score: 91.6633 bits (226), Expect = 9.329e-19
Identity = 79/329 (24.01%), Postives = 141/329 (42.86%), Query Frame = 2

Query: 6134 VKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLL-----SMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPS------HDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            +K   E   D GG   E    + +E+ N   F  +      D  T   NP+  I P+   YF F+G ++   +  ++ +D       +K M +  V + D+  +D   +NSL      S++    L F + DE +G    V    +    E+     K+ V++      V+R       +F + ++     F  + P  ++ +   R LE ++ G   I I+  K    Y     +D +  WFW+ +  ++  +++  L+F TG SR+P         S  P R  I  + +    LP+S TCFN++ LP+Y     M+  L +A+ + 
Sbjct:  486 IKFDGEEGLDYGGVSREFFFLLSHEMFNP--FYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRV----QEQFKAFMD----GFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGE-VQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEET 803

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
Match: HUL4 (Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex [Source:SGD;Acc:S000003797])

HSP 1 Score: 78.5666 bits (192), Expect = 1.054e-14
Identity = 86/373 (23.06%), Postives = 160/373 (42.90%), Query Frame = 2

Query: 6023 LVRIDRINKKEPVF-IQTCRQVINMDAVSLRL-------PWRAWKVKLVNEGADDAGGAYDETISEICNELEN--EAIFPRILTPIPSDTSTFIPNPDPTIPP----QYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNK------------TETEICHWGLKQKVDVNNVSDFVNRCIYYRLH-----EFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSK---TISIDILKNIARYVDADINDI-IFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHD-SHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKS 7033
            L+ +D+    +  F I+  R VI+ D  SLR          ++ +++ VNE   DAGG   E    +   L N    +F  I     S  +   PN D +       + ++  G++M  AI     +DL      +K++    +S +D   + P    +L+ M        D+ ++V+ +     +  N                E+C  G    +  +N  +FV + + + L      +++  +   ++ F   A    + + +   LE++VCG +         L+++ +YV    +D     WFWEI+ S++   +   L+FVT   R+P+   S IPF++ + +    ++ LP + TCFN+I L  Y S
Sbjct:  508 LISLDKGKSVDVYFKIKVRRDVISHD--SLRCIKEHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTE---DNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVF---AECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISL-LGSHDSDDLPLAHTCFNEICLWNYSS 871

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
Match: HUL5 (Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock [Source:SGD;Acc:S000003109])

HSP 1 Score: 59.6918 bits (143), Expect = 6.853e-9
Identity = 67/283 (23.67%), Postives = 121/283 (42.76%), Query Frame = 2

Query: 6302 QYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKS----IVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTET-----EICHWGLKQKVDVNNVSDFVNRCIYYRLHE--------FDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSK-TISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHD-SHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDM 7093
            +Y  FLG ++   +     ID+     F K++       + S  DL   D   +N+L+ +    +      DE+  +D  + F +++ E+     ++   G K  V  +NV  +V +   Y+L++        F   +  I      IAP  M ++ +   L+ ++ G +  I +D LK+   Y      D     FWE+L  F   EK  FL+FVT   + P      +  +  I  +      LP + TC N ++LP Y++++ +   L  AI+     D+
Sbjct:  642 KYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTT------DEIKSLD--LTFEIDEPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVI------IAPHWM-EMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDL 909

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
Match: SRM1 (Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant [Source:SGD;Acc:S000003065])

HSP 1 Score: 50.447 bits (119), Expect = 3.217e-6
Identity = 64/231 (27.71%), Postives = 93/231 (40.26%), Query Frame = 2

Query: 4694 VPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLK----KPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLG--NEILSGC--DTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGV----------GDV--KDRFSPTLVDFQK-KKLLKVICGKSFSAALTENGEVYTWGHSDF----VGTFLSDSEV 5311
            VP  + Y I  ++  K    HI+ +   G VF+WG G   +LG       +     P+    LR    I S  G  H   +T    L  +GL   GQ G   ++  G     P+ +   D    I  ++ G +H+L LS DG  LY+ G     ++G+           DV  K R  P         K   V  G   S A+ +NG  Y+WG  +     +G F  D+EV
Sbjct:  215 VPTFSKYNIVQLAPGK---DHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPF-GLRHVKYIAS--GENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPD-NVVIRSIAAGEHHSLILSQDGD-LYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEV 437

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
Match: EDO45583 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSK9])

HSP 1 Score: 542.347 bits (1396), Expect = 7.034e-163
Identity = 360/1205 (29.88%), Postives = 573/1205 (47.55%), Query Frame = 2

Query: 3587 LITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKL----LDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDN-IIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIG--FIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA-SCHAPYSYRNTIPSGP-QFQHKE--IPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRI----NKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTP-----IPSDTSTFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFD--SLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNREN 7126
            L    GH   V+ +    +   +ASGC+ G +N+WS++D  +  T   DG V+ + WT     VTA  R     +  +FN    +K+ +  WA       E  + + +  L     F   L +L    LD+   E+ +L + G  +V+S +LQ L   T  L+L   +       PI   + N++                        N LP   +  WL +    +    A+ F      N ++P          ++ +         N+ WSL    ++  W    PE W +      Y+WG G  G+   S     +     ++   QQ+VCG   T ++     ++ACGEG          ++ + +  +  L  Y +  ++ S+G + H +A+T  GEVFSWG G +GKLGHG++   ++P+ IEALRG+  +   CG  HSAVVT  G L+ FG G  G+LG+   +   TP  V   + +  IG V+CG+NHTL LS DG  ++AFG+G YGKLG+G    + SP  +D        K+ CG  FS  LT +G V+++G     G            E  L  P     +  +   FI D+C G +   ALT+   ++GWG+N +  L LG       P ++   K  +++QIS GRNH+AA +   P          P Q  H E   P+ P +       +E +   + ARL ++ ++++LV  +W+ +     +  +   Y+  +I                                F   ++R  + +   +  + R +  +M+  + Y   + + R+     K + +F+Q   QV  + +  L LP RAWKVKLV EGADDAGG +D+TI+E+C ELE   +   I TP     +  +   F+ NP  T       + FLGIL   A+RTKKP+DLHL P+ WK++    ++ DD+         SL  + +    G D  +  E+  ++ F   S +     +   G    +  +N S++V + + +RL EFD  +  +R+    I P+ +L +++  +LE++VCGS  +S+D+LK + RY + D +D + SW W +L SF   E+ LF+RFV+G+SRLP++   I  R  +    +  +SLP +QTCF Q+RLP Y S+  M   LR AI+ CRSIDMD+YML RN + 
Sbjct:  233 LFESVGHGGVVVAMAFDKSGMFVASGCDQGVLNIWSVQDGVVGHTYKQDGAVLSVVWTGDQG-VTAACRGSKTPVLFHFNEEWYKKHRVLAWAR------ERLRVQGITGLSESTCFRALLERLPTIMLDQYNYEKAKLSR-GDQLVHSPFLQSLAALTVGLDLDRVMCHALSRAPIPPCSWNEA------------------------NALP---EWLWLKSFCVAVHAADALTFRERFQKNFLVPN--------EEKISEDEPFQPLDNSSWSLTMDEQVMAWAMRRPEDWETGGKCDAYLWGGGRHGQLAESGRGVNVPTVTKSLASAQQVVCGQNCTFVVQVNGTILACGEGSYGRLGMGNSDDLFTLSPISALQGYVVIQIATSRGSDGHSLALTDSGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALRGEEVVNMACGFKHSAVVTVDGKLFTFGNGDYGRLGHGNSANKKTPERVTALE-KHAIGQVACGLNHTLVLSADGNTVWAFGDGDYGKLGLGSCTAKTSPQAIDVLAGIGCKKICCGTQFSVVLTNDGRVFSFGQERLTG----------QPEGRLRGPQKPQQIQALASHFIDDVCVGAEHVLALTSTGEVWGWGNNVDGQLGLGHSNAQREPCVIPDLKGKNIRQISAGRNHSAAWTAPPPPPRFPPGAPMPLQLGHPEHTPPQFPAL-------AEVSTVAVRARLRVLHHFSDLVYSSWKMFSLMPGE-VEAHAYNRGTI-------------------------------GFVRGQLRPLLATRVSNLPIVRAMGRTMVQGKNYGPQITVKRLIGRGKKSKAIFVQIATQVTKLKSADLCLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELEEGVVNLLIHTPNSTAEVGFNRDRFLLNPAATSEDDLVLYKFLGILFGVAVRTKKPLDLHLAPLVWKQLVGIPLTPDDI-------EESLRGIRDIHESGVDETTFAEIIPIETFETQSADGRFVPMVPSGHNIHLTFSNRSEYVEQALKFRLQEFDRQVAAVREGMGWILPVPLLSLLTPDNLEQLVCGSAEVSVDMLKRVVRYREIDPSDSLVSWLWRVLESFTNEERILFMRFVSGRSRLPANVGDITQRFQLVKLDRGVDSLPTAQTCFFQLRLPPYSSQEAMANRLRYAINNCRSIDMDNYMLTRNADE 1337

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
Match: EDO37196 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGI6])

HSP 1 Score: 359.377 bits (921), Expect = 3.302e-99
Identity = 304/1104 (27.54%), Postives = 489/1104 (44.29%), Query Frame = 2

Query: 3923 NLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEY--SNSTYIWGCGIKGEAGFSTNDDWIKP-TLMNINGIQ--QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA--SCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKKE--------------PVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELE----NEAIFPRILTPIPSDTS-----TFIPNPDPT--IPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIY--ISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            +L + +  L + L  Q+  E  LV+ G  +++S + + ++     L +   L+P  +       +R++  W         F+R  +     I ++L     L + F  D   K+ + I  E               C   +EY  H          +  +Q  +L  W    P  W   +  S + Y WG   +G+ G         P T+  +  I+  QIV G      +T E K+ A G G          +    I  +  L    +  V+   G + H +A++  G+V+SWG G  GKLGHG+  +  +P+ IEALRGKG I   CG  HSA +T +  LY +G G  G+LG+        P++V+   G  ++  V+CG     TL L TD   ++++G+G YGKLG G       P  V+      + KV CG  FS ALT +G VYTWG  D+  +G  + D         H+  P   ++L G   +I +  G+    A T+   +Y WG N    L  G       P LV   +   + +++CG  H  A  +C    + R  +P     ++  +  IPL                  RLIL+  ++EL                        S++L              L+   +   ++ P     +  +R  +      +   + +  +M+ +R +  ++ ++RI  K+               VF Q C ++ N    SL LP R WKVK + E  DD GG Y E+I+E+C+EL+    N ++   I+TP   + S      FI NPD T  +    F FLG+L+  AIRT  P+ L+L    WK++    ++V DL  +D  Y   L+ + +  +   +++D       F   S +  E  + H  +K  +   N  ++V   + +RLHEFD     +R+    + P+  L + +   LE +VCGS  I +D+LK++  Y   D N  +  WFW+ L SF+  E+SLFLRFV G++RLP   +    R F++  + K   P + LP+S TCF  +++PRY S   +   L+ A+  C+SID DDY  I
Sbjct: 3214 SLGSLVRGLPEALQRQYEYEEPLVRGGKHLMHSDFFKVMVALACDLGI--DLLPCCM-------DRHEWAW---------FRRFCMASR--IASSLESRLPLPYNFVQDVREKILELIPEE---------------CGDGEEYVSH--------TVFKREQDEQLLLWLNQRPSDWTMTWGGSGTIYGWGHNHRGQLGSLEGAKVKLPQTIEALASIRPVQIVGGEQTLFAVTAEGKVYATGYGHGGRLGLGGTDTVTSIKMLESLQHVVVRKVAVHSGGK-HAMALSADGDVYSWGEGDDGKLGHGNRNSCDRPRVIEALRGKGVIDISCGGSHSACITQNHELYTWGKGRYGRLGHGDSEDQLLPKVVEALRGN-RVIDVACGSGDAQTLCL-TDDDCVWSWGDGDYGKLGRGGSDGCKIPMKVESLIGLGVSKVECGSQFSVALTRSGAVYTWGKGDYYRLGHGVDD---------HVRRPKRVAALQG-KKVITIATGSLHCVASTDTGEVYTWGDNDEGQLGDGTTNAIARPRLVTALQGKKISRVACGSAHTIAWSTCKPVNAGR--LPDEVPMEYNHLQHIPLAATRN-------------RLILLHEFSELF---------------------CTSVTL------------FDLDPGHEETLDYGPL--VGLDTLRGVLIPSNKETAFRKVVQTTMVRDRQHGPVIELNRIQVKKYRSKGGLAGPDGTKSVFGQACDKMSNFGPESLFLPHRVWKVKFIGESVDDCGGGYSESIAEMCDELQASYHNGSLPLLIVTPNGREESGANRDCFILNPDATSAVHLGMFRFLGMLIGIAIRTGSPLSLNLAEPTWKQLAGMTLTVTDLAEIDKDYVPGLMCIRDMDAAALEAMDM-----PFSTPSASGREMRL-HAKMK-TICQENREEYVRLALNHRLHEFDQQCSAVREGMGRVVPVPFLSLFTGPELETMVCGSPDIPLDLLKSVVTYKGIDGNAPLVRWFWDTLESFSNAERSLFLRFVWGRTRLPRTIADFRGRDFVFQVLDKYNPPDHYLPESYTCFFLLKMPRYSSHRILCEKLKYAVHFCKSIDSDDYARI 4204

HSP 2 Score: 146.747 bits (369), Expect = 1.118e-34
Identity = 110/375 (29.33%), Postives = 180/375 (48.00%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMNING---IQQIVCGSGVTLLITCESKLMACGEGL--EMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGN-EILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P L    G   +QQI  GS     ++ + K+ ACGE     +   P     T     +  L+ + +  VS   G   H +A+TI G++FSWG G  GKLGHG+      PK I+  +        CG  HSA + +SG LY +GLG  G+LG+ +  +     ++  FT    ++  ++CG     TLAL+ DG  ++++G+G +GKLG G  +    P  V+  Q + + KV CG  FS AL+ +G V+TWG  D+         +   +++H+  P +   L G   I+D+  G     A+T++  ++ WG N +             P+LV   +   + +++CG +H+ A
Sbjct: 2424 FVWGLNDKDQLGGLKGSKIKVPVLSEFIGALKVQQIAGGSKTLFAVSHDGKVFACGESTNGRLGLGPLSANVTVPR-QIENLSSFMVRKVSVHSGGR-HAMALTIEGKLFSWGEGEDGKLGHGNRMNCDHPKLIDTFKSSCVRDMSCGSSHSAAILSSGELYTWGLGEYGRLGHGDNYTHLKPKKVQSFTSH--RVIDIACGSRDAQTLALTDDG-TVWSWGDGDFGKLGRGGSEGCSVPNPVEKLQGQGVCKVACGAQFSLALSTSGLVWTWGKGDYY-------RLGHGNDTHVRKPQIVDGLRG-KKIVDVAVGALHCLAVTDSGQVFAWGDNDHGQQGNNTTTVNRRPQLVNGLEGQKITRVACGSSHSIA 2785

HSP 3 Score: 134.42 bits (337), Expect = 4.764e-31
Identity = 104/286 (36.36%), Postives = 142/286 (49.65%), Query Frame = 2

Query: 4754 HIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPE--LVFFEKDIHLQQISCGRNHAAA-SCHAPYS 5593
            H +A+T  GEV+SWG G  GKLGHG  +  ++P  +  L GK  I   CG  HSA VT+ G LY +G G  G+LG+        P LV    G   I  V+CG    HTLA + DG  ++++G+G YGKLG G      +P  ++  Q   + KV CG  FS ALT +G V+TWG  +  G  L         E H+  P L  +L G   ++D+  G+    ALT+   +Y WG N     +LG       PE  LV       +  I+CG   + A SC   +S
Sbjct:   28 HFLALTREGEVYSWGSGDGGKLGHGDTSPREEPTLVTGLAGKQVIRISCGSTHSAAVTSEGELYTWGRGNYGRLGHGSSEDQLVPVLVSGLRGHHIID-VACGSGDAHTLAAADDG-TVWSWGDGDYGKLGRGGSDGCKNPKSIERLQGLGVCKVYCGAQFSLALTRDGSVWTWGKGE--GFRLGHGT-----EDHVRHPKLVEALDG-KHVVDVSVGSIHCLALTDAGEVYCWGRNDQG--QLGDIDCQIRPEPTLVSGLASKGIVGIACGPAQSFAWSCAGQWS 301

HSP 4 Score: 114.775 bits (286), Expect = 5.059e-25
Identity = 90/292 (30.82%), Postives = 136/292 (46.58%), Query Frame = 2

Query: 4397 LKQQTELFQ--WYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIV---CGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGE 5254
            L ++ E+ Q   + D   +         Y WG G  G+ G        +PTL+     +Q++   CGS  +  +T E +L   G G          E+    + V  L  + I  V+   G ++H +A    G V+SWG G +GKLG G +   K PKSIE L+G G     CG   S  +T  G ++ +G G   +LG+        P+LV+  DG+  +  VS G  H LAL TD  ++Y +G    G+LG  D + R  PTLV     K ++ + CG + S A +  G+
Sbjct:   11 LSRKCEIVQVVTHTDGKHFLALTREGEVYSWGSGDGGKLGHGDTSPREEPTLVTGLAGKQVIRISCGSTHSAAVTSEGELYTWGRGNYGRLGHGSSEDQLVPVLVSGLRGHHIIDVACGSG-DAHTLAAADDGTVWSWGDGDYGKLGRGGSDGCKNPKSIERLQGLGVCKVYCGAQFSLALTRDGSVWTWGKGEGFRLGHGTEDHVRHPKLVEALDGKHVVD-VSVGSIHCLAL-TDAGEVYCWGRNDQGQLGDIDCQIRPEPTLVSGLASKGIVGIACGPAQSFAWSCAGQ 299

HSP 5 Score: 92.4337 bits (228), Expect = 2.464e-18
Identity = 76/259 (29.34%), Postives = 119/259 (45.95%), Query Frame = 2

Query: 4844 KKPKSIEALRGKGSIMSDCGHM---HSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSY 5596
            + P  +E L  K  I+    H    H   +T  G +Y +G G  G+LG+   S  + P LV    G+  I  +SCG  H+ A++++G+ LY +G G YG+LG G  +D+  P LV   +   ++ V CG   + + A  ++G V++WG  D+  +G   SD   +         P     L G+G     C G   + ALT +  ++ WG      L  G + H  +P+LV      H+  +S G  H  A   A   Y
Sbjct:    3 QPPAELECLSRKCEIVQVVTHTDGKHFLALTREGEVYSWGSGDGGKLGHGDTSPREEPTLVTGLAGKQVI-RISCGSTHSAAVTSEGE-LYTWGRGNYGRLGHGSSEDQLVPVLVSGLRGHHIIDVACGSGDAHTLAAADDGTVWSWGDGDYGKLGRGGSDGCKN---------PKSIERLQGLGVCKVYC-GAQFSLALTRDGSVWTWGKGEGFRLGHGTEDHVRHPKLVEALDGKHVVDVSVGSIHCLALTDAGEVY 249

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
Match: EDO45579 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSK3])

HSP 1 Score: 154.836 bits (390), Expect = 1.822e-37
Identity = 125/373 (33.51%), Postives = 183/373 (49.06%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKPTLMNING-IQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIE-ALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYY----PELVFFEKDIHLQQISCGRNHAAA 5572
            Y+WG     +    + D  + P L    G  QQI  G   T +I  +  + ACG+G              ++  +   N+  +  VS+SKG + H +A+T+ G+V+SWG G +GKLGHG++ T K PK +E AL  K       G+ HSA VT  G LY +G G  G+LG+   +  + P  V   D    +G V+CG  HT+ +S DGQ +++FG G  GKLG  D    + P +++  Q   + KV CG   S ALT  G+VY WG    +GT      VD T  +  L+  L S  V     +D+  G+    ALT + ++Y WG   NN +   G+ H       P+ V     + + QIS G +H  A
Sbjct:  367 YVWGSNSSHQLAEGSMDKILVPKLATSFGSAQQIEAGQYCTFVIFPDGFVHACGKGSYGRLGLGDSTNQTQLKRLNFDNECLVKSVSSSKGSDGHTLALTLDGKVYSWGDGDYGKLGHGNSQTQKIPKLVEGALGNKVVCCIAAGYRHSAAVTEDGELYTWGEGDYGRLGHGDNNSRNVP--VQVKD-VANVGQVACGSAHTVCVSQDGQTVWSFGSGDNGKLGHSDTNRVYKPKVIEALQGMVIRKVCCGSQCSLALTSTGQVYVWGCGPSLGT----GSVDATSATPKLLLALQSHSV-----VDISVGDSHCVALTQDNNVYAWG---NNSMGQCGQGHCTTPITKPKKVLGLDGVAVHQISAGTSHTVA 724

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
Match: EDO32366 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVB1])

HSP 1 Score: 110.923 bits (276), Expect = 4.618e-27
Identity = 57/161 (35.40%), Postives = 89/161 (55.28%), Query Frame = 2

Query: 6599 NNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYI----SKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAI 7069
             N  ++V   + +RLHEFD     +R+    + P+  L + +   LE +VCGS  I +D+LK++  Y   D N  +  WFW+ L SF+  E+SLFLRFV G++RLP   +    R F++        P + LP+S TCF  +++PRY S   +   L+ A+
Sbjct:   58 ENREEYVRLALNHRLHEFDQQCSAVREGMGRVVPVPFLSLFTGPELETMVCGSPDIPLDLLKSVVTYKGIDGNAPLVRWFWDTLESFSNAERSLFLRFVWGRTRLPRTIADFRGRDFVFQVLDKYNPPDHYLPESYTCFFLLKMPRYSSHRILCEKLKYAV 218

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
Match: EDO36112 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJK1])

HSP 1 Score: 109.383 bits (272), Expect = 2.194e-25
Identity = 89/345 (25.80%), Postives = 151/345 (43.77%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNEL--------ENEAIFPRILT---PIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLD----EVYGVD-----KFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDI--IFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W+VK + EG  D GG + E++ E+ +EL        E    F R       +     +++P+P  T    Y  +LG ++    R+ + + L   P  WK +    V+          +    + ++EAA +  D L+    ++Y        KF     + T  E+   G    V   +   F       R+ E    +  +R+   ++ P   L +++W  LE+ +CG+  +S  +LK+  +Y D D+++      + W  L  F   E+S FLRFVTG+ R P+     PF   +  +    N+LP + TC + I  P Y S +   A LR A+  C +ID D
Sbjct:   11 WEVKFIGEGIIDQGGGFRESLVEMTDELCPPEFGSLEVLPFFVRTANNKDAVGDYQDSYLPSPSCTEWSVY-EWLGKILGALYRSDENMTLTFPPFLWKLLVGEHVT----------WAKDFVDVDEAAVMFTDELERMDEDLYVATYRNECKFSTVLSDGTTKELIPGGNDVTVGPADRQRFAALLREARMTESVQQVLALRRGLMSVIPESALSLITWNELERGICGNPDVSPSVLKSACKYGD-DLSESSECIKFLWAALAQFTNDERSRFLRFVTGRRRPPA-----PFT--VAKAGDGRNALPTASTCASTIYWPAYTSAAMATARLRYAVYNCVAIDTD 336

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
Match: herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:101167612])

HSP 1 Score: 313.923 bits (803), Expect = 5.899e-85
Identity = 265/946 (28.01%), Postives = 423/946 (44.71%), Query Frame = 2

Query: 4382 NNFWSLKQQTELFQWYQDSPEYWI--SEYSNSTYIWGCGIKGEAGFSTNDDWIKPT----LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKK--------------EPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTS-----TFIPNPDPTIPPQ--YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSM--NEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK--QPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            ++ +  +   +L QW  + P+ W   +  S + Y WG   +G+ G         PT    L  +  +Q ++ G      +T + KL A G G          E       +  +    I  V+ + G + H +A++  GEV+SWG    GKLGHG+     +P+ IE+LRG   +    G  HSA +TASG L+ +G G  G+LG+        P+LVD   G  ++  V+CG     TL L TD   ++++G+G YGKLG G       P  +D      ++KV CG  FS ALT++G VYT G  D+         +    + H+  P     L G   +I +  G+      T +  +Y WG N    L  G       P LV   +   + +++CG  H  A   +  +    +P+    ++  + EI ++         ++F ++    I +           +  + QT  H     +D                                      IS+ ++    + + +TM R        +R +  +V ++RI  K              + VF Q C ++ +    SL LP R WKVK V E  DD GG Y E+I+E+C EL+N      I+TP   D S      F+ NP    P     F FL +L+  AIRT  P+ L+L    WK++    +++ DL  +D  +   L+ +  NEA S  F+++   + V        N +  +I        + + N +++V   I Y LHEFD  +  +R+    + P+ +L + +   LE +VCGS  I + +LK++A Y   +    +  WFWE++ SF+  E+SLFLRFV G++RLP   +    R F+   + K   P + LP+S TCF  ++LPRY  +  +E  L+ AI  C+SID DDY  I
Sbjct: 3862 HDLFKREHDEQLVQWM-NRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPTEALATLRPVQ-LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGN-RPCDRPRVIESLRGVEVVDIAAGGAHSACITASGELFTWGKGRYGRLGHGDSEDQLKPKLVDALQGH-RVIDVACGSGDAQTLCL-TDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYT-GKGDY-------HRLGHGSDDHVRRPRQVQGLQG-KKVIAIATGSLHCVCCTED-EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSAHTLAWSTSKPTNAGKMPAQVPMEYNHLQEISVMALRNRLLLLHHFSELFCPCIPM--------FDLEGRLGQTG-HGPSVGFDT--------------------------------LRGILISQGKEAAFRKVVQATMVR--------DRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFV-ESVDDCGGGYSESIAEMCEELQNSLTPLLIVTPNGRDESGANRDCFLLNPAAKSPLHMGMFRFL-VLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMTLPFTVP-------NASGQDIQLSSKYSHITLENRAEYVRLAINY-LHEFDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGVEPTAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVVQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARI 4732

HSP 2 Score: 143.665 bits (361), Expect = 2.368e-33
Identity = 99/308 (32.14%), Postives = 155/308 (50.32%), Query Frame = 2

Query: 4547 MNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGS----IMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSN 5455
            ++  G+ QIVC   V L+++              ++    +  T   + +  L+  KI  ++A    + H +A++  GEV+SWG G  G+LGHG A  L++P  I    GK +    +   CG  +SA VTA G LY +G G  G+LG+       TP LV    G+ K+  V+CG      L+    +++++G+G YGKLG G      +P LV+  Q   ++KV CG  FS ALT++G+VYTWG  D       +  +    + H+  P L  SL     ++D+  G+    ALT+   ++ WGSN
Sbjct:  421 LSSTGVTQIVCSEKVFLILSRSG----------AVYTQNYKSTTLAPMLIHGLSSRKIVKLAAHPDGQ-HFLALSTSGEVYSWGCGDGGRLGHGDAY-LEEPALITTFSGKQTGKQVVQIACGSTYSAAVTADGELYTWGRGNYGRLGHSS-EDVTTPMLVTALKGQ-KVVDVACGSGDAQTLAVTENQVWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGD-------NQRLGHGTDEHVRYPKLLDSLQK--KVVDIAVGSTHCLALTDEGEVHSWGSN 705

HSP 3 Score: 141.739 bits (356), Expect = 8.195e-33
Identity = 112/372 (30.11%), Postives = 179/372 (48.12%), Query Frame = 2

Query: 4475 YIWGCGIKGEAGFSTNDDWIKP----TLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRII-NVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            ++WG   K + G         P    TL  +N +Q  V G   +L  T E K+ ACGE         +   T +I   +  L++Y +  V+       H +A+T+ G+VFSWG G  GKLGH  +    KP+ IEAL+ K      CG  HSA +T+SG LY +GLG  G+LG+   +    P+LV    G  ++  V+CG      L+   + ++++G+G +GKLG G  +    P  ++    + + ++ CG  FS ALT++G V+T G  D+   F      D+    H+  P +   L G   I+ +  G     A+T++  +Y WG N +     G       P LV   +   + +++CG +H+ A
Sbjct: 2911 FVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQ--VAGGSKSLFATVEGKIYACGEATNGRLGLGLSSGTIQIPRQISALSNYVVKKVAVHS---RHAMALTVDGKVFSWGEGDDGKLGH-FSRNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGH-RVIQVACGSRDAQTLALTDELVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT-GKGDY---FRLGHGTDV----HVRKPQIVEGLRG-KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3266

HSP 4 Score: 97.0561 bits (240), Expect = 3.374e-19
Identity = 87/261 (33.33%), Postives = 127/261 (48.66%), Query Frame = 2

Query: 4475 YIWGCGIKGEAG-FSTNDDWIKPTL---MNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALT 5242
            + WG G  G+ G FS N D  KP L   +    I+ I CGS  +  IT   +L + G G              R   V VL  +++  V A    ++  +A+T    VFSWG G  GKLG G +     P++IE L G+G    +CG   S  +T SG ++  G G   +LG+        P++V+   G+ KI  V+ G  H LA++  GQ +YA+G+  +G+ G G       PTLV   + +K+ +V CG S S A T
Sbjct: 3015 FSWGEGDDGKLGHFSRNCD--KPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGHRVIQV-ACGSRDAQTLALT-DELVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT-GKGDYFRLGHGTDVHVRKPQIVEGLRGK-KIVHVAVGALHCLAVTDSGQ-VYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3268

HSP 5 Score: 94.3597 bits (233), Expect = 2.152e-18
Identity = 94/338 (27.81%), Postives = 144/338 (42.60%), Query Frame = 2

Query: 4607 CESKLMACG-EGLEMIFNPFMREETYRIINVPVL-------NDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGC-DTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFS-----PTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            C S  + C   GL ++    +R +   +  VP L       +D K     A K       A +I  +VF WG+    +LG    + +K P   E L    +++   G   S   T  G +Y  G   NG+LG  + SG    PR +        +  V+    H +AL+ DG K++++GEG  GKLG       FS     P L++  + K++  + CG S SAA+T +GE+Y+WG  ++         +   D +  L P L   L+G   I   C   D  T ALT+   ++ WG      L  GG      P+ +       + QI CG   + A
Sbjct: 2845 CRSSGIDCKIHGLNIVGR--IRADEEDLATVPFLASDNEEEDDEKTAAGLARKKSSGLESAASIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSAL-NVVQVAGGSKSLFATVEGKIYACGEATNGRLGLGLSSGTIQIPRQISALSNY-VVKKVAVHSRHAMALTVDG-KVFSWGEGDDGKLG------HFSRNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEY-------GRLGHGDNTTQLRPKLVKVLLGHRVIQVACGSRDAQTLALTDEL-VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLA 3163

HSP 6 Score: 85.5001 bits (210), Expect = 9.795e-16
Identity = 67/232 (28.88%), Postives = 108/232 (46.55%), Query Frame = 2

Query: 4427 YQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIK-PTLMNI-NGIQ------QIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQ 5098
            + D   +     S   Y WGCG  G  G    D +++ P L+   +G Q      QI CGS  +  +T + +L   G G          + T  ++ V  L   K+  V+   G ++  +A+T   +V+SWG G +GKLG G +   K PK +E L+    +   CG   S  +T  G +Y +G G N +LG+        P+L+D    + K+  ++ G  H LAL+ +G+
Sbjct:  474 HPDGQHFLALSTSGEVYSWGCGDGGRLGH--GDAYLEEPALITTFSGKQTGKQVVQIACGSTYSAAVTADGELYTWGRGNYGRLGHSSEDVTTPML-VTALKGQKVVDVACGSG-DAQTLAVT-ENQVWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSL--QKKVVDIAVGSTHCLALTDEGE 698

HSP 7 Score: 81.2629 bits (199), Expect = 1.625e-14
Identity = 74/272 (27.21%), Postives = 121/272 (44.49%), Query Frame = 2

Query: 4781 EVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFT---DGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKK----LLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDT-TFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            EV +WG+     LG      +  P   +AL   G     C      +++ SG +Y      +  L   ++ G  + ++V      DG+           H LALST G+ +Y++G G  G+LG GD        +  F  K+    ++++ CG ++SAA+T +GE+YTWG  ++    L  S  D+T       P L ++L G   +   C   D  T A+T N  ++ WG      L  GG      P+LV   +D+ + ++ CG   + A
Sbjct:  397 EVIAWGL-----LGWKLYANVCGPIHCKALSSTGVTQIVCSEKVFLILSRSGAVYTQNYK-STTLAPMLIHGLSSRKIVKLAAHPDGQ-----------HFLALSTSGE-VYSWGCGDGGRLGHGDAYLEEPALITTFSGKQTGKQVVQIACGSTYSAAVTADGELYTWGRGNY--GRLGHSSEDVT------TPMLVTALKGQKVVDVACGSGDAQTLAVTEN-QVWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVA 641

HSP 8 Score: 81.2629 bits (199), Expect = 1.905e-14
Identity = 68/230 (29.57%), Postives = 115/230 (50.00%), Query Frame = 2

Query: 4910 HSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGE---PKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGK--SFSAALTENGEVYTWGHSDF--VGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELV-FFEKDIHLQQISCGRNHAAA 5572
            H   ++ SG +Y +G G  G+LG+   +  + P L+    G+    ++  ++CG  ++ A++ DG+ LY +G G YG+LG    +D  +P LV   + +K++ V CG   + + A+TEN +V++WG  D+  +G   SD             P L   L  +  I+ +C G+  + ALT +  +Y WG   N  L  G   H  YP+L+   +K +    I+ G  H  A
Sbjct:  479 HFLALSTSGEVYSWGCGDGGRLGHGD-AYLEEPALITTFSGKQTGKQVVQIACGSTYSAAVTADGE-LYTWGRGNYGRLGHSS-EDVTTPMLVTALKGQKVVDVACGSGDAQTLAVTEN-QVWSWGDGDYGKLGRGGSDG---------CKTPKLVEKLQDLD-IVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQKKV--VDIAVGSTHCLA 692

HSP 9 Score: 80.4925 bits (197), Expect = 2.996e-14
Identity = 65/214 (30.37%), Postives = 102/214 (47.66%), Query Frame = 2

Query: 4463 SNSTYIWGCGIKGEAGFSTNDDWIKPTLMNI---NGIQQIVCGS--GVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALST 5089
            S   Y WG G  G  G   N   ++P L+ +   + + Q+ CGS    TL +T E  + + G+G          E      N+  LN   +  +          +A+T  G V++ G G + +LGHG    ++KP+ +E LRGK  +    G +H   VT SG +Y +G   +GQ GN   +    P LV   +G+ KI  V+CG +H++A +T
Sbjct: 3062 SGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGHRVIQVACGSRDAQTLALTDE-LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA---QFSLALTKSGVVWT-GKGDYFRLGHGTDVHVRKPQIVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWTT 3269

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
Match: ENSORLT00000035382.1 (pep primary_assembly:ASM223467v1:3:5797265:5802417:-1 gene:ENSORLG00000024579.1 transcript:ENSORLT00000035382.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 156.762 bits (395), Expect = 3.684e-42
Identity = 81/217 (37.33%), Postives = 125/217 (57.60%), Query Frame = 2

Query: 6308 FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMN--EAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI 6952
            F FLGILM  AIRTKKP+DLHL P+ WK++    + ++DL  +D  Y  +L S+   E + +  D+  E+  +D F+  S +     I   G    +  +N  ++V R I YRLHE D  +  +R+    I P+ +L +++ R LE++VCG   I  D+LK + RY + D    +  WFW+ L  F+  E+ LF+RFV+G+SRLP++ + I  R  I
Sbjct:    4 FKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLQLEDLEEVDLLYVQTLKSILHIEDSGITEDNFHEMIPLDSFIGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIGYRLHEIDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGMPEICCDVLKKVVRYREVDEQHTLVHWFWQTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQI 220

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
Match: ENSORLT00000043566.1 (pep primary_assembly:ASM223467v1:12:10210691:10213160:-1 gene:ENSORLG00000026831.1 transcript:ENSORLT00000043566.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 150.214 bits (378), Expect = 7.309e-40
Identity = 76/209 (36.36%), Postives = 120/209 (57.42%), Query Frame = 2

Query: 6308 FHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGF--DSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDS 6928
            F FLGILMA AIRTKKP+DLHL P  WK++    +   DL  +D   + +L  +    + G   ++   +  +D FV  S +     +   G    +   N +++V R + YRLHE DS +  +R+    I P+ +L +++ + LE++VCG   +S+++LK + RY D   ++ +  WFWE L  F   E+ LFLRFV+G+SRLPS+ +
Sbjct:   23 FRFLGILMAVAIRTKKPLDLHLAPWVWKQLCSMPLGGPDLEEVDLLTYRTLQGIVHLENSGITEENFHVMIPLDSFVAHSADGMLVPVVPGGQNISLTFANRTEYVERALDYRLHEMDSQVAAVREGMSTIIPVPLLSLLTAQQLEQLVCGLPEVSVEMLKRLVRYRDITESNQLIGWFWESLEEFTNEERVLFLRFVSGRSRLPSNPA 231

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
Match: hectd3 (HECT domain E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:101168239])

HSP 1 Score: 145.206 bits (365), Expect = 1.922e-34
Identity = 100/339 (29.50%), Postives = 161/339 (47.49%), Query Frame = 2

Query: 6128 WKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTST---------FIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVS-VDDLLRMDPSYFNSLLSMNEAASLGFD---SLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPA---NSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMD 7096
            W+ K + EG  D GG + ++++++  EL   +    I  P    TS          ++PNP      Q + ++G LM  A+R K  + L L  + WK++T   +S   D   +D    N L +M       F+     + VY          +    E+   G    V   + S+FV+     RL E    I  ++     + P  +LD+++W+ +EK VCG   IS++ LK + R+ D + ND+   + WE L +F   ++S FLRFVTG+SRLP+        ++++  KQ +   ++LPQS TC + + LP Y S    E  LR A   C +ID D
Sbjct:  525 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSAECPIPLPFFLRTSNQGSLEARDYYVPNPS-CKDFQKYEWIGQLMGAALRGKDFLVLALPGLVWKQLTGEAISWSKDFPSVDSVLVNLLEAMENMDKETFEFRFGEELVYNT-----LLTDGQMVELIPGGSSVAVRYEDRSEFVHLVQKARLEESKQQIAAMQAGLLKVVPQAVLDLLTWQEVEKKVCGDPEISVEALKRLTRFEDLEHNDVRVQYLWEALRNFTNEDRSRFLRFVTGRSRLPAP-------IYVFPEKQGSETTDALPQSSTCSSTLYLPNYPSAKVCEEKLRYAAYNCVAIDTD 850

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
Match: SMURF2 (E3 ubiquitin-protein ligase SMURF2 [Source:NCBI gene;Acc:101159489])

HSP 1 Score: 121.324 bits (303), Expect = 4.984e-27
Identity = 102/357 (28.57%), Postives = 164/357 (45.94%), Query Frame = 2

Query: 6050 KEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQ---YFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGV-DKFVCFSVNKTETEICHW----GLKQKVDVNNVSDFVNRCIYYR-LHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLP-----SHDSHIPFRLF-IYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQ 7075
            +E +F ++ RQV+ M    L   W+   +K   E   D GG   E +  + +E+ N   +  +      D  T   NPD  + P+   YFHF+G +M  A+     ID      F+K++    +++DD+  +DP   NSL+ +     LG D    + GV D   C   +     I H     G    V  +   ++V   + +R LH  ++    ++K F  + P  +L     + LE IVCG   I I   ++  R      +  I  WFW+ + SF+E  ++  L+FVTG SR+P     +       RLF I+     AN+LP++ TCFN+I +P Y+S   +   L  AI +
Sbjct:  428 REEIFEESYRQVMKMRPKDL---WKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNP--YYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGLAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWI-----LGND----ITGVLDHTFCVEHSAYGEIIPHELKPNGKSISVTEDTKKEYVRLYVNWRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIVDWRSNTRLKHCTTDSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDANANNLPKAHTCFNRIDIPPYESYEKLYDKLLTAIEE 770

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST
Match: SMESG000006057.1 (SMESG000006057.1)

HSP 1 Score: 4595.8 bits (11919), Expect = 0.000e+0
Identity = 2290/2383 (96.10%), Postives = 2297/2383 (96.39%), Query Frame = 2

Query:    2 MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFXXXXXXXXXXXHIQKESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSSASINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSKDEKLVKSLEFLYSKVVLMAXXXXXXXXXXXXSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDXXXXXXXXXXXXQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRVFFCASITSIGYCVCDEXXXXXXXXXXXXHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDTDFISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNR------QSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQICNKFFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 7132
            MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFSLNSNSLVSLNHI+KESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSS SINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSK +KLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRV+FCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDT FISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSK                                   + +   SPTIHLANCNATVKKLISVRNR      QSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSP IMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLT GELILLRIFDNGSLITHHPI GLSEIEL                              N   +DTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEIL GCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISS MYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAA+LGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI
Sbjct: 1842 MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFSLNSNSLVSLNHIKKESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSSVSINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSKGKKLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRVYFCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDTHFISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSK---------------------------------FTEKTCRYSPTIHLANCNATVKKLISVRNRHSSTFRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPEIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTHGELILLRIFDNGSLITHHPILGLSEIEL------------------------------NDIIMDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILCGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSAMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAAALGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 4161

HSP 2 Score: 78.1814 bits (191), Expect = 1.262e-13
Identity = 61/206 (29.61%), Postives = 94/206 (45.63%), Query Frame = 2

Query: 4697 PVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTP-RLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFG-EGVYGKLGVGDVKDRFSPTLVD---FQK----KKLLKVICGKSFSAALTENGEVYTWGHSDFVG 5287
            P+LND              HI+A+T  G+++SWG GS GKLGHG       P  IEALRG       CG  HS+ V+ +G  +++G   N    N     C  P RL      +  +  + CG + T  LS + + +Y  G +    +L   D   +  P++++   F K    +K+ K+    +    L  NG +Y+ GH   +G
Sbjct:  432 PILND------------SQHILALTQHGQLYSWGGGSFGKLGHGDMLDKHSPTLIEALRGYNIRNISCGASHSSAVSETGLGFVWG---NPHAFNSKDENCLFPVRL-----RQAIMSSIVCGPHSTFFLSINKRNVYYLGSQCSENELFTKDFILQHYPSIIEGLPFTKCDKSEKIEKIAVNSTVVLVLLNNGNLYSIGHGINLG 617

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST
Match: SMESG000006057.1 (SMESG000006057.1)

HSP 1 Score: 4451.35 bits (11544), Expect = 0.000e+0
Identity = 2215/2303 (96.18%), Postives = 2223/2303 (96.53%), Query Frame = 2

Query:  224 NISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFXXXXXXXXXXXHIQKESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSSASINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSKDEKLVKSLEFLYSKVVLMAXXXXXXXXXXXXSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDXXXXXXXXXXXXQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRVFFCASITSIGYCVCDEXXXXXXXXXXXXHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDTDFISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQICNKFFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 7132
            +ISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFSLNSNSLVSLNHI+KESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSS SINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSK +KLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRV+FCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDT FISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSK                                   + +   SPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSP IMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLT GELILLRIFDNGSLITHHPI GLSEIEL                              N   +DTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEIL GCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISS MYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAA+LGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI
Sbjct: 2115 SISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFSLNSNSLVSLNHIKKESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSSVSINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSKGKKLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRVYFCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDTHFISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSK---------------------------------FTEKTCRYSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPEIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTHGELILLRIFDNGSLITHHPILGLSEIEL------------------------------NDIIMDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILCGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSAMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAAALGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 4354

HSP 2 Score: 156.762 bits (395), Expect = 1.965e-37
Identity = 75/76 (98.68%), Postives = 76/76 (100.00%), Query Frame = 2

Query:    2 MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNI 229
            MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKN+
Sbjct: 1842 MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNV 1917

HSP 3 Score: 77.7962 bits (190), Expect = 1.461e-13
Identity = 61/206 (29.61%), Postives = 94/206 (45.63%), Query Frame = 2

Query: 4697 PVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTP-RLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFG-EGVYGKLGVGDVKDRFSPTLVD---FQK----KKLLKVICGKSFSAALTENGEVYTWGHSDFVG 5287
            P+LND              HI+A+T  G+++SWG GS GKLGHG       P  IEALRG       CG  HS+ V+ +G  +++G   N    N     C  P RL      +  +  + CG + T  LS + + +Y  G +    +L   D   +  P++++   F K    +K+ K+    +    L  NG +Y+ GH   +G
Sbjct:  432 PILND------------SQHILALTQHGQLYSWGGGSFGKLGHGDMLDKHSPTLIEALRGYNIRNISCGASHSSAVSETGLGFVWG---NPHAFNSKDENCLFPVRL-----RQAIMSSIVCGPHSTFFLSINKRNVYYLGSQCSENELFTKDFILQHYPSIIEGLPFTKCDKSEKIEKIAVNSTVVLVLLNNGNLYSIGHGINLG 617

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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST
Match: SMESG000006057.1 (SMESG000006057.1)

HSP 1 Score: 4450.2 bits (11541), Expect = 0.000e+0
Identity = 2215/2303 (96.18%), Postives = 2223/2303 (96.53%), Query Frame = 2

Query:  224 NISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFXXXXXXXXXXXHIQKESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSSASINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSKDEKLVKSLEFLYSKVVLMAXXXXXXXXXXXXSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDXXXXXXXXXXXXQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRVFFCASITSIGYCVCDEXXXXXXXXXXXXHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDTDFISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSNSLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTRGELILLRIFDNGSLITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQICNKFFLDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 7132
            +ISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFSLNSNSLVSLNHI+KESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSS SINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSK +KLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRV+FCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDT FISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSK                                   + +   SPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSP IMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLT GELILLRIFDNGSLITHHPI GLSEIEL                              N   +DTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEIL GCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISS MYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAA+LGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI
Sbjct: 2139 SISTPGIGSSLLFAFFLLNEHVNNRFCRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVICSIFSLNSNSLVSLNHIKKESSNNIRKSIFFEAVSNYIITNSDAIGSLSTFFSSVSINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLSSHIFLEAYLTSKGKKLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEATLKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRTLKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLFQNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVNKPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDGVIVDLDNRVYFCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEGYLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEVNYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVLSSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGRLRLNKHIDKLSNRVHCIRFKDTHFISVLILALESSLDSDEKIHNFIHIYIHNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFLIKNDYQIWQSEIEQIMELLAFGIISQNTVSK---------------------------------FTEKTCRYSPTIHLANCNATVKKLISVRNRQSILTADCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPEIMEKCLQMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSKPYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTHGELILLRIFDNGSLITHHPILGLSEIEL------------------------------NDIIMDTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLNEPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFCGHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGIEWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKAKSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILCGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYDMTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSAMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAAALGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLIRNRENDI 4378

HSP 2 Score: 156.762 bits (395), Expect = 2.122e-37
Identity = 75/76 (98.68%), Postives = 76/76 (100.00%), Query Frame = 2

Query:    2 MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNI 229
            MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKN+
Sbjct: 1842 MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIYLYEIVGVLLEKSIYINQFDLYFDKNV 1917

HSP 3 Score: 77.7962 bits (190), Expect = 1.686e-13
Identity = 61/206 (29.61%), Postives = 94/206 (45.63%), Query Frame = 2

Query: 4697 PVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTP-RLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFG-EGVYGKLGVGDVKDRFSPTLVD---FQK----KKLLKVICGKSFSAALTENGEVYTWGHSDFVG 5287
            P+LND              HI+A+T  G+++SWG GS GKLGHG       P  IEALRG       CG  HS+ V+ +G  +++G   N    N     C  P RL      +  +  + CG + T  LS + + +Y  G +    +L   D   +  P++++   F K    +K+ K+    +    L  NG +Y+ GH   +G
Sbjct:  432 PILND------------SQHILALTQHGQLYSWGGGSFGKLGHGDMLDKHSPTLIEALRGYNIRNISCGASHSSAVSETGLGFVWG---NPHAFNSKDENCLFPVRL-----RQAIMSSIVCGPHSTFFLSINKRNVYYLGSQCSENELFTKDFILQHYPSIIEGLPFTKCDKSEKIEKIAVNSTVVLVLLNNGNLYSIGHGINLG 617

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST
Match: SMESG000054104.1 (SMESG000054104.1)

HSP 1 Score: 288.886 bits (738), Expect = 1.625e-77
Identity = 295/1119 (26.36%), Postives = 481/1119 (42.98%), Query Frame = 2

Query: 3935 FILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFTTSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNINNTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEYAHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWI------SEYSNSTYIWGCGIKGEAGFSTNDDWIKPTL---MNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHG----HATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTD---------GQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAASCHAPYSYRNTIPSGPQFQHKEIPE--IPLIKYTTLYNSEYN--FYDMTARLILILYWNEL-------VRLTWQFWIPQTNQHYDKSDYD------LNSISLGSKSLDNASRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMINNRTYTSLVRIDRINKKEPVFIQTCRQVIN-MDAVS------------LRLPWRAWKVKLVNEGADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPPQYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSLLSMNEAASLGFDSLDEVYGVDKFVCFSVN-KTETEICHWGLKQKVDVNNVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPSHDSHIPFRLFI--YISK-QPANS-LPQSQTCFNQIRLPRYKSRSDMEACLRIAISQCRSIDMDDYMLI 7111
            F+L L K++ +QF  E   VKS   + YS++L+ LI+ +  + L  S+ P         S  ++  W         F+   L +      +L  N  L + F    + +       E  + D +      +  V   EYA            +S +   ++  W +  P+ W       S      + WG   +G+ G         P L   ++    +QI+ G     +++ + ++ A G G          E     I V  L +  +  V+ + G + H +A+   G V++WG     KLG          +  P  +++L     I    G  HSA ++ SG LY +G G  G+LG+        P++V+   G   IG V+CG     TL ++ +            ++++G+G YGKLG G       P  ++  +   ++KV CG  FS  LT +GEVYTWG  D+         +    ++H+  P   + L     IID+  G+      T +  +Y WG N    L  G       P ++       + +++CG  H  A          T  SG +    E P+  + L    T  N   N     +  R +L+ +W EL       + L  Q  + +  Q    S  +      + +   GSK      +VN +L+  + +            +EV    + E       R  NG +   RT        +I  ++ VF Q   ++I   D +S              LP R WKVKL+ E  DD GG Y E+I+EIC+EL+N    P  ++    D     P  D T   ++F FLG L+  AIRT +P+ L +  + WK ++   ++ +DL   D    +SL+S+        ++L   Y V       VN   ET    +     V+ +N + +++  I Y++HEFD     IR+    + P+ +L++ S R LE +VCG+ +I I  LK+I  Y     +D+I  WFWEI+       +SLFLRFV G++RLP + S +  + F+   +SK  PA+  LP++ TCF  ++LP Y S++ ++  L  AI  C+SID+DDY  I
Sbjct: 3981 FLLCLQKVVLKQFKFEEPEVKSSKQLFYSRFLKSLIELSCYIRL-DSISP--------VSTADEWAW---------FRNYCLTYR--TTESLITNSSLPYRF----INEFKSRFLKEPTVKDPLTREINAITAVS--EYADP--------REFSYQHDLQIVGWLKSRPDAWKKCWPIDSASGLEVWSWGHNHRGQLGGVEGSKIKVPVLCEHLSALRPRQIIGGEQSLFIVSIDGRVYATGFGNNGRLGIGSTESVQTPILVSGLEEKIVVKVAVNSGGK-HCLALCNNGLVYAWGDAEDNKLGLDIRVQPGEDVLTPTLVKSLVKAEIIDIAAGGSHSAAISRSGELYTWGKGRYGRLGHGNGDDQPFPKIVEALRGYHVIG-VACGSGDAQTLCITKNEDSRIDLVPNTSVWSWGDGDYGKLGRGGFDICKLPMKIETLEGAGVIKVDCGSQFSLVLTASGEVYTWGKGDYF-------RLGHGSDNHVRKPEKVAQL-NRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIESLTGKGINRVACGSAHTLAW---------TTVSGNKSHETESPDQRLSLSTRPTSCNLLENKSAVSLINRFLLLHHWTELFCSNLHFMDLNRQSVMDKVRQILLPSSKESLFRLMVQTTMYGSKKHGPEIKVN-RLHASAGTPAGVSILQRAGWAEVENHCDDE-------RRDNGDICVGRT--------KIQLEKTVFGQLGGKLIEEADCISKSGSIFVPPPDFFLLPNRVWKVKLIGESVDDCGGGYSESITEICDELQN-GHLPFFISSPDKDCFVLSPYADKT-NTKWFIFLGCLLGIAIRTNQPLSLTVSDLIWKILSGQSLNKNDLQLFDKDLLSSLMSLKAIDETELENLQIPYSVTAIDGKEVNLNIETSGAIF-----VNASNRNSYIDEVINYKIHEFDKTCLFIRRGISLVIPLPLLNLFSSRELECLVCGNDSIPISFLKSITLYRGVKSDDLIIIWFWEIMEEMTNEVRSLFLRFVWGRTRLPRYVSDLRGKEFVIQVLSKYSPADDYLPEAYTCFFLLKLPNYSSKAILQEKLLYAIHFCKSIDIDDYARI 5023

HSP 2 Score: 138.658 bits (348), Expect = 5.469e-32
Identity = 115/403 (28.54%), Postives = 178/403 (44.17%), Query Frame = 2

Query: 4430 QDSPEYWISEYSNSTYIWGCGIKGEAGFSTNDDWIKPTLMNINGIQQIVC-----GSGVTLLITCESKLMACGEG--------------LEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMN--HTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVD-FQKKKLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISCGRNHAAA 5572
            QD+ ++  S   +  Y+WG   K + G       +K  ++N   + ++ C     GS     +T   K+   G+                E+I  P   E          L+ Y I  V+   G   H IA+T  GE FSWG G  GKLGH     L  P+ I+  +GK  +   CG  HSA +   G LY +GLG  G+LG+   +    P LV  +  + K+  V+CG     TLAL++D   ++++G+G +GKLG G       P  ++      ++++ CG   S ALTENG+V+TWG  D+         +    + H+  P     L     I+ L  G     A+T+   +Y WG N +     G   +   P LV    D  +  ++CG +H+ A
Sbjct: 3112 QDNSKFK-SRIMSKIYVWGLNDKDQLGCEATSK-VKLPILN-EALSELDCVSISGGSKSLFCVTRTGKVYVAGDSSNGRLGIGSDTDITAEVIIGPKRLE---------ALDKYFIVKVAVHSGGR-HAIALTKNGETFSWGEGDDGKLGHNSRLKLNYPRKIKYFKGKRVVDVACGSSHSAAIVFGGHLYTWGLGDYGRLGHGDTAMRLHPELVK-SLRDYKVVQVACGSRDAQTLALTSDF-TVWSWGDGDFGKLGRGGSSGCLIPQKIECMSLSNVIQIECGAQSSFALTENGQVWTWGKGDYY-------RLGHGTDKHIREPMQIEDLKKTK-IVHLAVGALHCLAVTDRGQVYSWGDNDHGQQGNGTVTYNMRPTLVSALMDNKIAHVACGSSHSVA 3491

HSP 3 Score: 68.1662 bits (165), Expect = 1.103e-10
Identity = 43/139 (30.94%), Postives = 75/139 (53.96%), Query Frame = 2

Query: 5066 NHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSPTLVDFQKK---KLLKVICGKSFSAALTENGEVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGNDTTFALTNNCHLYGWGSNANNLLR 5473
            +H LA++  GQ +Y++G    GKLG GD KDR  PT++D   +   ++ +V CG+  S  LT++G++Y+ G  + +G        D+ D  HL +    S L+G+  +  +      +  L+N+  ++ WGS  +N  R
Sbjct:  529 SHVLAVTEAGQ-VYSWGTNTSGKLGQGDTKDRKRPTIIDTFSRCHLQVKQVACGEEHSLILTQSGDIYSCGR-NHMGQL---GHGDVKDR-HLPIRITASDLIGV-LVKQIAVDGHQSMCLSNDGAIFTWGSTFDNCRR 660

HSP 4 Score: 64.3142 bits (155), Expect = 1.827e-9
Identity = 49/180 (27.22%), Postives = 70/180 (38.89%), Query Frame = 2

Query: 4751 SHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEAL-RGKGSIMS-DCGHMHSAVVTASGGLYMFGLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQKLYAFGEGVYGKLGVGDVKDRFSP---TLVDFQKKKLLKVICGKSFSAALTENGEVYTWGHS 5275
            SH++A+T  G+V+SWG  + GKLG G     K+P  I+   R    +    CG  HS ++T SG +Y                                    SCG NH                   G+LG GDVKDR  P   T  D     + ++      S  L+ +G ++TWG +
Sbjct:  529 SHVLAVTEAGQVYSWGTNTSGKLGQGDTKDRKRPTIIDTFSRCHLQVKQVACGEEHSLILTQSGDIY------------------------------------SCGRNH------------------MGQLGHGDVKDRHLPIRITASDLIGVLVKQIAVDGHQSMCLSNDGAIFTWGST 654

HSP 5 Score: 58.151 bits (139), Expect = 1.324e-7
Identity = 41/154 (26.62%), Postives = 67/154 (43.51%), Query Frame = 2

Query: 4481 WGCGIKGEAGFSTNDDWIKPT---LMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMIFNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGIGSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTAS 4933
            WG G  G+ G   +   + P     M+++ + QI CG+  +  +T   ++   G+G          +     + +  L   KI H++       H +A+T  G+V+SWG   HG+ G+G  T   +P  + AL         CG  HS   TAS
Sbjct: 3345 WGDGDFGKLGRGGSSGCLIPQKIECMSLSNVIQIECGAQSSFALTENGQVWTWGKGDYYRLGHGTDKHIREPMQIEDLKKTKIVHLAVGA---LHCLAVTDRGQVYSWGDNDHGQQGNGTVTYNMRPTLVSALMDNKIAHVACGSSHSVAWTAS 3495

[Close]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST
Match: SMESG000059703.1 (SMESG000059703.1)

HSP 1 Score: 104.76 bits (260), Expect = 8.961e-22
Identity = 98/379 (25.86%), Postives = 166/379 (43.80%), Query Frame = 2

Query: 6026 VRIDRINKKEPVFIQTCRQVINMDAVSL--RLPWRAWK----VKLVNEGADDAGGAYDETISEICNEL--ENEAIFPRILTPIPSDTSTFIPNPDPTIPP---QYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYFNSL--LSMNEAASLGFDSLDEVYGVDKFVCFSVNKTET-EICHWGLKQKVDVNNVSDFV--------NRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVCGSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTGKSRLPS------HDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEACLRIAISQC 7078
            +R D  ++ E   +Q  R  +  D+     R     WK    +K +NE   D GG   E   ++ +E+   N A+F      +  D  T+  NP   +      YF F+G  +A AI   K +  +    F+K +    +   DL + D  +F  L  L  N+ +++    LD+ + +         +TET ++   G +  V   N S++V           I  +LH F        + F  I P  ++ I + + LE ++CG   I ++ LK    Y           WFW+ L SF++ +++ F++FVTG S++P          + P +  I ++    N LP + TCFN I LP+Y++   +  CL  AI +C
Sbjct: 3698 LRNDGDSRYEEELVQVSRARLFEDSYGRLHRKTAEEWKQRFCIKFINEEGQDGGGLLREWYLKMSHEIFNPNYALFK-----VSPDGVTYTINPASYVNNNHLSYFKFVGRFIAKAIFDNKLLTCYFTRAFYKHILGISIRYTDLEKEDYQFFRGLEFLLKNDVSTMF---LDQTFSIQ---ISEFGQTETRDLIPNGSQILVTEENKSEYVRLVCQEKMTGAIRQQLHSF-------LEGFYEIIPKNLISIFNEKELELLICGLPEIDLNDLKINTVYNKYTPASPQIQWFWQALESFDQEDRARFIQFVTGTSKVPLGGFSKLEGMNGPTKFQISLASMSTNHLPAAHTCFNSIDLPQYENFDKLHKCLLTAIREC 4058

The following BLAST results are available for this feature:

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Zebrafish
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HERC1	1.831e-174	28.32	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC2	1.457e-98	27.02	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC2	4.673e-98	28.51	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC2	1.793e-60	35.34	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HECTD3	7.530e-35	28.86	HECT domain E3 ubiquitin protein ligase 3 [Source:...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eel-1	2.123e-23	28.02	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]
eel-1	2.251e-23	28.02	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]
eel-1	2.368e-23	28.02	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]
eel-1	2.387e-23	28.02	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]
eel-1	2.428e-23	28.02	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HERC2	6.371e-90	28.06	gene:FBgn0031107 transcript:FBtr0301344	[more]
Herc4	5.730e-27	28.22	gene:FBgn0035207 transcript:FBtr0310555	[more]
Herc4	1.439e-26	28.41	gene:FBgn0035207 transcript:FBtr0072670	[more]
Herc4	1.439e-26	28.41	gene:FBgn0035207 transcript:FBtr0072671	[more]
HUWE1	4.895e-22	26.44	gene:FBgn0030674 transcript:FBtr0339688	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
herc1	1.546e-175	29.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
herc1	1.546e-175	29.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
LO018116.1	1.136e-62	35.71	pep chromosome:GRCz11:CHR_ALT_CTG6_1_36:37834788:3...	[more]
herc2	6.985e-60	32.86	HECT and RLD domain containing E3 ubiquitin protei...	[more]
herc2	5.496e-35	32.29	HECT and RLD domain containing E3 ubiquitin protei...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HERC1	1.477e-44	29.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC1	5.553e-179	29.44	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC2	4.898e-96	28.48	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC2	5.024e-96	28.48	HECT and RLD domain containing E3 ubiquitin protei...	[more]
HERC2	5.068e-96	28.48	HECT and RLD domain containing E3 ubiquitin protei...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Herc1	1.673e-176	28.85	HECT and RLD domain containing E3 ubiquitin protei...	[more]
Herc2	4.526e-100	27.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
Herc2	4.821e-100	27.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
Herc2	4.821e-100	27.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
Hectd3	1.424e-33	28.86	HECT domain E3 ubiquitin protein ligase 3 [Source:...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q15751\|HERC1_HUMAN	8.793e-174	28.32	Probable E3 ubiquitin-protein ligase HERC1 OS=Homo...	[more]
sp\|Q4U2R1\|HERC2_MOUSE	3.372e-99	27.21	E3 ubiquitin-protein ligase HERC2 OS=Mus musculus ...	[more]
sp\|O95714\|HERC2_HUMAN	2.244e-97	28.51	E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens ...	[more]
sp\|Q9VR91\|HERC2_DROME	6.387e-89	28.06	Probable E3 ubiquitin-protein ligase HERC2 OS=Dros...	[more]
sp\|Q3U487\|HECD3_MOUSE	9.959e-33	28.86	E3 ubiquitin-protein ligase HECTD3 OS=Mus musculus...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A210R2T9	7.142e-41	28.99	E3 ubiquitin-protein ligase HERC1 OS=Mizuhopecten ...	[more]
V4BCY8	1.936e-41	31.07	Uncharacterized protein OS=Lottia gigantea OX=2251...	[more]
A0A5G3L5I9	2.037e-179	29.21	HECT and RLD domain containing E3 ubiquitin protei...	[more]
A0A5G3L226	8.719e-176	29.44	HECT and RLD domain containing E3 ubiquitin protei...	[more]
A0A2K6EJT9	9.192e-175	28.68	HECT and RLD domain containing E3 ubiquitin protei...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
herc2	1.038e-97	28.54	HECT and RLD domain containing E3 ubiquitin protei...	[more]
ENSAMXT00000014806.2	1.944e-82	42.78	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
ENSAMXT00000042389.1	3.238e-38	35.55	pep primary_assembly:Astyanax_mexicanus-2.0:14:343...	[more]
hectd3	2.094e-33	29.20	HECT domain E3 ubiquitin protein ligase 3 [Source:...	[more]
SMURF2	5.233e-27	26.42	SMAD specific E3 ubiquitin protein ligase 2 [Sourc...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000001275.1	3.063e-44	31.96	pep scaffold:Pmarinus_7.0:GL476529:184068:212443:-...	[more]
ENSPMAT00000005516.1	1.043e-25	26.84	pep scaffold:Pmarinus_7.0:GL477585:22018:44632:1 g...	[more]
smurf2	2.853e-19	25.67	SMAD specific E3 ubiquitin protein ligase 2 [Sourc...	[more]
nedd4a	1.154e-18	24.65	NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;A...	[more]
NEK9	3.136e-18	29.24	NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
TOM1	4.142e-24	25.28	E3 ubiquitin ligase of the hect-domain class; has ...	[more]
RSP5	9.329e-19	24.01	NEDD4 family E3 ubiquitin ligase; regulates proces...	[more]
HUL4	1.054e-14	23.06	Protein with similarity to hect domain E3 ubiquiti...	[more]
HUL5	6.853e-9	23.67	Multiubiquitin chain assembly factor (E4); proteas...	[more]
SRM1	3.217e-6	27.71	Nucleotide exchange factor for Gsp1p; localizes to...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO45583	7.034e-163	29.88	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37196	3.302e-99	27.54	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45579	1.822e-37	33.51	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32366	4.618e-27	35.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36112	2.194e-25	25.80	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
herc2	5.899e-85	28.01	HECT and RLD domain containing E3 ubiquitin protei...	[more]
ENSORLT00000035382.1	3.684e-42	37.33	pep primary_assembly:ASM223467v1:3:5797265:5802417...	[more]
ENSORLT00000043566.1	7.309e-40	36.36	pep primary_assembly:ASM223467v1:12:10210691:10213...	[more]
hectd3	1.922e-34	29.50	HECT domain E3 ubiquitin protein ligase 3 [Source:...	[more]
SMURF2	4.984e-27	28.57	E3 ubiquitin-protein ligase SMURF2 [Source:NCBI ge...	[more]

BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000006057.1	1.262e-13	96.10	SMESG000006057.1	[more]
SMESG000006057.1	1.965e-37	96.18	SMESG000006057.1	[more]
SMESG000006057.1	2.122e-37	96.18	SMESG000006057.1	[more]
SMESG000054104.1	1.625e-77	26.36	SMESG000054104.1	[more]
SMESG000059703.1	8.961e-22	25.86	SMESG000059703.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30035968 ID=SMED30035968|Name=HECT and RLD domain containing E3 ubiquitin protein ligase family member 1|organism=Schmidtea mediterranea sexual|type=transcript|length=7780bp
AATGATATCCGTGAAACAATTGCGCTTATCTGAAATGTATGATGACGTTG
AGTTCTATAATAATACTCAGATATCACCGGATTATTATCTTGTTTTGAAG
CATCTCTATGTTGAGTTCAATAATTTTTTTGCAGTTATTCCTGACATATA
TTTATATGAAATTGTTGGAGTGTTATTAGAAAAATCTATTTATATAAATC
AATTCGATTTGTATTTTGATAAAAATATATCGACACCGGGAATTGGTAGT
TCACTGTTGTTTGCCTTCTTCTTATTGAATGAACATGTGAATAATCGATT
CTGTCGAGGTGAAATATGCCAATATTCCACCACAGAAAATGGAAAAGAAA
TTCAATGCTCAGGAATCATTTTCAATTTCAAAAGTAAAGGAAAAATTCAC
TTACGCGGTTTAAACTTTTTTGATAAATTGACAAAGTCAGAAGATGTAAT
TTGTAGCATTTTTTCTTTAAATTCAAATTCGTTGGTATCTCTAAATCACA
TTCAAAAAGAAAGCAGCAATAATATTAGAAAGTCAATTTTTTTCGAAGCA
GTCAGTAACTACATAATAACAAATAGTGATGCTATTGGGAGTTTAAGTAC
ATTTTTTAGTTCAGCGTCAATTAATTATTTTGATGCTGACATCATAAATT
TCGAAGGAATGGAGTGGTTGAAAGAACTTTCAGAGCGTTCGAAAATTGAA
TATTATTTTATTCGATACCAATATTCGCAGTTTATCATGAAACTTTTATC
AAGTCATATTTTCCTGGAAGCATATTTAACTAGCAAAGACGAAAAACTTG
TAAAGAGTTTAGAATTTTTATATTCTAAAGTTGTCTTAATGGCGCCAAGA
CCTTGCCCATTGAGAAGAAACAGAAATTTATCTGAATTTACTGAAGCAAC
CCTGAAACTTGTTGAATGTTTTTATCAATATTTTTTCGAAAACGAATTGG
GTCTCGTGAAAAAATGTGCATATTTATACATGGAAAACTATCATTCACTC
GATTTAAAAGGATTTTTAAACAAAAATGATCGTCGAATTTTATTGAGAAC
TCTCAAAAGGCAGTCTATTGATAAAAGTCTAATCGAGAATTTTACTTTGA
AATCGAAAGGATCTGAACAAACGTTGGAGTCAGGATTAGTTTCTTTCAGT
GACAGAAGGCGACGATTAGGTGATTATCTCTCACCATTTAATGTGCTTTT
TCAAAATCAGCTACCTGCCGATGAATATGATTCGCCACCATCAAACCCGG
CGGAAGTAGATTCCTCTTTTTCGACTGAAACATCGAATGAATCCTCACAA
GTGGAACCAAGTCAAAGATTAATGGACGAATTTATTTTACGATCAGTGAA
TAAGCCTAGAAAAACCTTTATTTGTCCTATTTGTGATGCATCATTCAAAT
ATCAGTCCCAACATTTATTTACCCATTTGTCTTATCATCACCCGTTAAAT
TGCAAGAAAGCCTTTCAACACCACGCATCAAATTGTATCAAATCAGATGG
AGTGATTGTCGATTTGGATAATAGGGTATTTTTCTGTGCCTCAATAACAT
CAATTGGTTACTGCGTCTGTGACGAATACCTGAAAATGAAATACCCGCCA
AAGAAATTACCACATATTAATGAAAATTTAAATTATTTTGTCAATGAAGG
TTATTTACATAATAATCTTATTGGTTGGAGTGGAACATTGGTGACTGAAC
ATTATTGCTACCAAAAGATTTCCGAGGTTTGCATGTCAGAAGACATTAGG
CCAAAGCTAGATCAAGTAAAAATTCTTGGCGATCATATTCGGCAAGAAGT
TAATTACTGCACCATTTCCTTGGATTCTTATTGCTATGAGCCTGACACCA
CTGAATGTTCTTTGCAAGGAGATATTTCATTTATATGTCAATTGAACGCG
GAGGCAATAGTTAAATGTTTAAGACGCTTAGAATATTCATTCCTTGTTTT
ATCGTCTAGAAATATAATCATTAAATTAGCAAAAAGAATATTCCTAAGTT
ACAGAAATTCTAACTCAGATGCTGTTTCCACAATAAAGAAATTTTACTTT
AATGATTTAATGTTTTCTGTAAATATGATTCGGTTATTTGAAGGGGGTCG
ATTGCGTTTAAATAAACACATTGATAAACTTTCAAATCGTGTTCATTGTA
TTCGGTTCAAAGATACTGATTTCATTTCAGTATTGATCTTAGCACTCGAA
TCAAGCTTGGATAGCGATGAAAAAATCCACAATTTTATTCATATTTATAT
TCACAATTTGGAAAATTTTCTCACTTGCTCACAAGAATATTTTAATCTTA
ATGCGGATTTTGATACTTCTTTATTAATTAGACCTAGCGCTTTGATTATC
CAATTATTGTTTAATATTGTCATTAGAGTTCTATCTAAAAACAACTTCCT
TATCAAAAATGATTATCAAATCTGGCAATCTGAAATTGAACAGATAATGG
AATTGTTAGCATTTGGCATCATTAGTCAAAATACAGTATCTAAAGTAAAA
ATTTGGTGTTTGCAAAACTTAATGAAGATGTTTCAACTGATCCAATCTAA
TAGTTTACCGAAAAACCCTGCCGATGTTAACATGGTTGACTTATTAGAAG
ATCTGAGCATTGAAGACTCACCAACAATTCATTTGGCCAATTGTAATGCT
ACAGTTAAAAAATTAATCTCCGTTAGAAATAGGCAAAGCATTCTCACCGC
TGATTGTGAAGGAACGATGCGTTTATGGGATATAGATTCTATTATTGGAA
CAGAGCAAAATCTGAAACAGACATTTTTGTTTTCACTTGGAGATCAGATA
TTGAAAAGAACTTCAGATAGAAACAGTCCGGGAATAATGGAGAAATGTCT
GCAAATGACGGAACCTTTAAGAATCGATCTATCAAATTATCTTGTCCAAG
TTGGAGTGCAAAATATTGCAGTTAGTCCCACTGGATCTTATTTAGCAGAA
TCACTTGGAATTTACTTGAATATTTGGAGTACAAAAAGTATTTATTCCAA
ACCTTACGTAACCTCGTTTTCAAGTTTAATTACCACTTTGATATTTCCTC
AACAAACATCTAATGGGTTGCATGAAACTCCTGTCGATTTATTACTGGTC
TGTCTTACTCGTGGGGAGTTGATATTATTGCGAATTTTTGACAATGGTTC
CCTAATCACTCATCATCCCATACAGGGACTGTCGGAGATCGAATTAAATG
TAACAATGGCTGCTTGGGATGAAGAAAGCAATCTAATTGCAATAGGATAT
CATAATGGGTCCGTCATACTAACCGATCAGATTTGCAACAAATTTTTTTT
AGATACCGTGCACAATAATCGAATATCATATCTCCTTTATTCTCCATACA
CTTCACATTTCGGATGCACTTTTTTGGCATCATCTTCGGTTGATGAAAAT
AACCTTGCAATTTGGAAGAAAGATAAATTGACATGTGTTTTATCTTTGAA
TGAGCCAATTACTTGCATAGAATGGTTATCAAGGAAATATATTAATGATA
AGAATCATCATGTCATCATAGCAGGGTTATCTACTGGTCTGATTCAATTT
TGGCAATTCAGTGATACTGGTGATGACGTTAAAAACCTTATCACTTTTTG
TGGACACATGTGCTCGGTTTTGAAATTAAGAGTGTGTGATAATACTAATC
TACTAGCCAGTGGGTGTAATAATGGCTGGGTAAATGTATGGAGTCTGAAA
GACCGTTCTTTGATAAGTACATGTAATGGTGATGGATATGTTATTGGAAT
TGAATGGACACCGCAAAATAATCTAGTAACAGCTTTTTCCCGCTCTCAAT
ACATTAAAATTTGGAGATATTTTAATTCCAATACTTTACAAAAAAACGGA
ATATGTCAATGGGCATATATTAGGAAACTTTTTCTTGAGTCAACTAAAGC
TAAATCAGTGAAACATTTAAAGAATCTGAAAAACTTTATTTTGTCTCTTC
ATAAATTATTAGATGAACAATTTCTTGAAGAAGTTGAGCTTGTAAAATCC
GGATTTTCTATTGTCTATTCACAATATCTACAATGTTTAATTCAATTCAC
AACTTCACTTAACCTCACTGGAAGCTTAATGCCATATTATGTAATGGAAC
CCATTGATGCAAGCAACCGAAATAAATCACTGTGGATGTTAGAAATACCA
AGTGAAACATGTTTTCAACGAGCAATCCTGCGGCATAATCTGAATATCAA
TAACACATTGCCGCCAAATCATCAATTACATTGGTTGTTCACTATTGATG
AAGTTATGAAGCTTACGCAGGCGATTTGTTTTGAACGTGATATTCCGGAT
AATATTATCCCTAGGTGGTGGTGGGTTTGGTGCGTTGGATCCGATGAATA
TGCACATCATTATCTTCAATCTAAATGGAAAAACAATTTCTGGTCTTTAA
AACAACAAACTGAACTTTTTCAATGGTATCAGGATTCACCAGAATATTGG
ATTAGTGAATATTCTAATTCTACCTATATTTGGGGATGTGGAATCAAAGG
AGAAGCGGGTTTTTCAACGAATGACGATTGGATAAAACCAACATTAATGA
ACATAAATGGAATACAGCAGATAGTTTGTGGCAGTGGAGTGACATTGCTA
ATTACGTGTGAAAGTAAATTAATGGCTTGTGGCGAAGGATTAGAGATGAT
ATTCAATCCATTCATGCGAGAAGAAACATATCGAATTATTAATGTGCCAG
TTCTAAATGATTACAAAATAACGCACGTTTCAGCGTCAAAGGGCCCAGAA
AGTCATATAATTGCAATTACTATTTTCGGAGAAGTATTTAGCTGGGGTAT
TGGGTCCCATGGAAAATTAGGGCATGGACATGCTACTACATTGAAAAAAC
CGAAATCAATTGAAGCACTTAGAGGAAAAGGGTCAATTATGTCTGACTGT
GGTCACATGCATAGCGCTGTTGTTACAGCATCGGGAGGACTTTACATGTT
TGGTTTGGGTGTCAATGGACAATTAGGAAATGAGATTCTTTCTGGTTGTG
ATACTCCTCGTCTAGTAGATTTCACGGACGGAGAACCTAAAATTGGGTTT
GTATCTTGTGGCATGAATCATACGCTAGCTTTATCAACTGACGGGCAAAA
ATTATATGCGTTTGGTGAAGGTGTTTATGGAAAATTGGGGGTTGGGGATG
TCAAAGACCGTTTTAGTCCAACACTTGTTGATTTTCAAAAGAAAAAGCTT
TTGAAGGTTATCTGTGGTAAAAGCTTTAGTGCTGCTTTAACTGAAAATGG
CGAAGTTTATACTTGGGGACATTCGGACTTTGTGGGAACATTTCTATCAG
ATTCTGAAGTTGATTTAACGGATGAAAGTCATTTACTTGTTCCTACTCTT
AATTCGAGTCTCGTTGGCATTGGTTTTATTATAGACCTTTGTGCAGGAAA
CGATACCACATTTGCTTTAACGAACAATTGTCATTTATATGGATGGGGTT
CAAATGCTAACAATTTATTGCGATTAGGAGGTAAAGCGCATGCCTATTAT
CCAGAACTCGTTTTTTTCGAAAAGGACATTCATTTGCAACAAATATCGTG
TGGTAGAAATCACGCTGCTGCTAGCTGTCATGCTCCTTATTCATACCGAA
ATACAATTCCATCTGGCCCTCAATTTCAACACAAAGAGATTCCTGAAATT
CCTCTGATTAAATATACAACTTTATATAATTCTGAATATAATTTCTATGA
CATGACTGCCCGATTAATTCTTATATTGTATTGGAATGAATTGGTACGTT
TAACATGGCAATTTTGGATTCCTCAAACCAATCAGCATTATGATAAATCT
GATTATGATTTGAATTCCATTAGTTTAGGATCCAAATCTTTAGACAATGC
ATCTCGTGTGAACTCTAAATTAAATTTGTTTTCACAGTCTAATTGGAATT
GGAAACCATTTAATAATTTTAATATTAGTGAAGTACGACAGTTTATAAAT
AGTGAATTTATATCATCAACTATGTACCGATATATAAATGGCAGTATGAT
TAATAATCGGACCTATACGTCCCTTGTTCGCATTGATAGAATCAACAAAA
AAGAACCGGTATTTATTCAGACTTGTCGACAAGTTATAAACATGGATGCT
GTTAGTCTACGATTGCCTTGGAGAGCTTGGAAAGTCAAATTGGTTAATGA
AGGAGCGGATGATGCTGGAGGGGCATATGATGAAACTATATCTGAAATTT
GCAATGAACTAGAAAACGAGGCTATATTTCCAAGAATACTTACTCCTATT
CCAAGTGATACAAGCACTTTCATTCCTAATCCTGATCCAACAATACCTCC
CCAGTATTTCCATTTCCTTGGAATCTTGATGGCAACTGCTATTCGAACCA
AAAAACCTATTGACTTGCATTTAGATCCAATATTTTGGAAGCGAATGACA
AAATCTATTGTTTCAGTTGATGATTTGCTACGGATGGATCCTTCTTATTT
CAATAGTTTGTTATCAATGAATGAAGCAGCTTCTTTGGGATTTGACAGCC
TTGATGAAGTGTATGGGGTTGATAAATTCGTTTGTTTTTCTGTGAATAAA
ACTGAAACAGAAATTTGTCATTGGGGATTGAAACAAAAAGTTGATGTGAA
TAATGTGTCGGATTTTGTCAATAGATGCATATATTACAGGTTGCACGAAT
TTGATAGTGCAATTGAGCATATTCGTAAAAGTTTTTGTAATATTGCTCCT
ATGGTTATGTTGGATATCATGAGTTGGAGGCATTTGGAGAAAATTGTCTG
TGGTTCCAAAACTATTAGCATTGACATTTTGAAGAATATTGCTAGGTATG
TTGACGCGGATATAAATGATATCATTTTTTCTTGGTTTTGGGAAATTCTC
GGATCATTCAATGAATTAGAAAAAAGTCTATTTCTAAGATTCGTAACTGG
TAAAAGTCGACTACCCTCACACGATTCTCATATTCCTTTCAGATTATTTA
TATATATTTCTAAACAGCCTGCAAATAGTTTGCCTCAATCTCAAACGTGT
TTTAATCAAATCCGTCTACCTAGGTACAAATCTCGATCCGATATGGAAGC
TTGTTTGAGAATTGCGATAAGTCAGTGTCGTAGTATAGATATGGATGATT
ATATGCTCATTAGGAATAGAGAAAATGATATTTAAATTTTTTGTAATTAT
TTACTGTATTTCCCCAGTGTATCCTTTTCATTATTTTGGAATTATTTTTG
ATAATTTTAAATGTGACATTTATTTATACAAAAAAGATATTTTTGTTTAA
TAACTTCTGTATATAAATATATAATAAATTAATGGAAAATTGGATAATCA
AATTCCATATTGTTGTCCTGATTTTGATGCCATTCCTTCAAAGTTACCTA
TGTTGTGGCTACCATGGCAACCAATGCCATATCATTTTTTACATCTTTCT
AAAAATAACTTTTAATGCTTTTTATTTTGTATCGTTTCTTATTGGTCATA
AATATGTTGACGTTTGTCGGTGAAATAATTAATTGATAATTATAGATCTA
ATTTCAAGTGTGCCATGGAAAGTCTGAAAATGTGAAGAACTTTATTTGAA
TTGTTTAAATTATGTATCATCAATATTGTTACAAGGGTTAACTTGACACA
AATTTACGGATATATGGTTGTTGTCTATAAAGATCGTCAGTATATTATTT
TTTGGTTGGAATCGAATTTTTTTAGTGTGTAGGCATAGATGTTTTTCTCA
TATTAACAGACGTGTTAAGAATTATATATGTCTTAAGCGATTTAGATTGG
TATGTTTTCATGGTAATATTGTTGTTGGGC

protein sequence of SMED30035968-orf-1

>SMED30035968-orf-1 ID=SMED30035968-orf-1|Name=SMED30035968-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=2378bp
MISVKQLRLSEMYDDVEFYNNTQISPDYYLVLKHLYVEFNNFFAVIPDIY
LYEIVGVLLEKSIYINQFDLYFDKNISTPGIGSSLLFAFFLLNEHVNNRF
CRGEICQYSTTENGKEIQCSGIIFNFKSKGKIHLRGLNFFDKLTKSEDVI
CSIFSLNSNSLVSLNHIQKESSNNIRKSIFFEAVSNYIITNSDAIGSLST
FFSSASINYFDADIINFEGMEWLKELSERSKIEYYFIRYQYSQFIMKLLS
SHIFLEAYLTSKDEKLVKSLEFLYSKVVLMAPRPCPLRRNRNLSEFTEAT
LKLVECFYQYFFENELGLVKKCAYLYMENYHSLDLKGFLNKNDRRILLRT
LKRQSIDKSLIENFTLKSKGSEQTLESGLVSFSDRRRRLGDYLSPFNVLF
QNQLPADEYDSPPSNPAEVDSSFSTETSNESSQVEPSQRLMDEFILRSVN
KPRKTFICPICDASFKYQSQHLFTHLSYHHPLNCKKAFQHHASNCIKSDG
VIVDLDNRVFFCASITSIGYCVCDEYLKMKYPPKKLPHINENLNYFVNEG
YLHNNLIGWSGTLVTEHYCYQKISEVCMSEDIRPKLDQVKILGDHIRQEV
NYCTISLDSYCYEPDTTECSLQGDISFICQLNAEAIVKCLRRLEYSFLVL
SSRNIIIKLAKRIFLSYRNSNSDAVSTIKKFYFNDLMFSVNMIRLFEGGR
LRLNKHIDKLSNRVHCIRFKDTDFISVLILALESSLDSDEKIHNFIHIYI
HNLENFLTCSQEYFNLNADFDTSLLIRPSALIIQLLFNIVIRVLSKNNFL
IKNDYQIWQSEIEQIMELLAFGIISQNTVSKVKIWCLQNLMKMFQLIQSN
SLPKNPADVNMVDLLEDLSIEDSPTIHLANCNATVKKLISVRNRQSILTA
DCEGTMRLWDIDSIIGTEQNLKQTFLFSLGDQILKRTSDRNSPGIMEKCL
QMTEPLRIDLSNYLVQVGVQNIAVSPTGSYLAESLGIYLNIWSTKSIYSK
PYVTSFSSLITTLIFPQQTSNGLHETPVDLLLVCLTRGELILLRIFDNGS
LITHHPIQGLSEIELNVTMAAWDEESNLIAIGYHNGSVILTDQICNKFFL
DTVHNNRISYLLYSPYTSHFGCTFLASSSVDENNLAIWKKDKLTCVLSLN
EPITCIEWLSRKYINDKNHHVIIAGLSTGLIQFWQFSDTGDDVKNLITFC
GHMCSVLKLRVCDNTNLLASGCNNGWVNVWSLKDRSLISTCNGDGYVIGI
EWTPQNNLVTAFSRSQYIKIWRYFNSNTLQKNGICQWAYIRKLFLESTKA
KSVKHLKNLKNFILSLHKLLDEQFLEEVELVKSGFSIVYSQYLQCLIQFT
TSLNLTGSLMPYYVMEPIDASNRNKSLWMLEIPSETCFQRAILRHNLNIN
NTLPPNHQLHWLFTIDEVMKLTQAICFERDIPDNIIPRWWWVWCVGSDEY
AHHYLQSKWKNNFWSLKQQTELFQWYQDSPEYWISEYSNSTYIWGCGIKG
EAGFSTNDDWIKPTLMNINGIQQIVCGSGVTLLITCESKLMACGEGLEMI
FNPFMREETYRIINVPVLNDYKITHVSASKGPESHIIAITIFGEVFSWGI
GSHGKLGHGHATTLKKPKSIEALRGKGSIMSDCGHMHSAVVTASGGLYMF
GLGVNGQLGNEILSGCDTPRLVDFTDGEPKIGFVSCGMNHTLALSTDGQK
LYAFGEGVYGKLGVGDVKDRFSPTLVDFQKKKLLKVICGKSFSAALTENG
EVYTWGHSDFVGTFLSDSEVDLTDESHLLVPTLNSSLVGIGFIIDLCAGN
DTTFALTNNCHLYGWGSNANNLLRLGGKAHAYYPELVFFEKDIHLQQISC
GRNHAAASCHAPYSYRNTIPSGPQFQHKEIPEIPLIKYTTLYNSEYNFYD
MTARLILILYWNELVRLTWQFWIPQTNQHYDKSDYDLNSISLGSKSLDNA
SRVNSKLNLFSQSNWNWKPFNNFNISEVRQFINSEFISSTMYRYINGSMI
NNRTYTSLVRIDRINKKEPVFIQTCRQVINMDAVSLRLPWRAWKVKLVNE
GADDAGGAYDETISEICNELENEAIFPRILTPIPSDTSTFIPNPDPTIPP
QYFHFLGILMATAIRTKKPIDLHLDPIFWKRMTKSIVSVDDLLRMDPSYF
NSLLSMNEAASLGFDSLDEVYGVDKFVCFSVNKTETEICHWGLKQKVDVN
NVSDFVNRCIYYRLHEFDSAIEHIRKSFCNIAPMVMLDIMSWRHLEKIVC
GSKTISIDILKNIARYVDADINDIIFSWFWEILGSFNELEKSLFLRFVTG
KSRLPSHDSHIPFRLFIYISKQPANSLPQSQTCFNQIRLPRYKSRSDMEA
CLRIAISQCRSIDMDDYMLIRNRENDI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR036322	WD40_repeat_dom_sf
IPR035983	Hect_E3_ubiquitin_ligase
IPR000408	Reg_chr_condens
IPR001680	WD40_repeat
IPR000569	HECT_dom
IPR015943	WD40/YVTN_repeat-like_dom_sf
IPR009091	RCC1/BLIP-II
IPR017986	WD40_repeat_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000408	Regulator of chromosome condensation, RCC1	PRINTS	PR00633	RCCNDNSATION	coord: 1745..1766 score: 27.27 coord: 1579..1595 score: 23.53 coord: 1491..1507 score: 34.31 coord: 1687..1705 score: 29.82 coord: 1595..1609 score: 37.78
IPR000408	Regulator of chromosome condensation, RCC1	PFAM	PF00415	RCC1	coord: 1644..1694 e-value: 9.9E-7 score: 29.3 coord: 1701..1746 e-value: 1.3E-6 score: 28.9 coord: 1593..1641 e-value: 8.3E-8 score: 32.7
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS00626	RCC1_2	coord: 1684..1694
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS50012	RCC1_3	coord: 1489..1537 score: 9.74
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS50012	RCC1_3	coord: 1593..1644 score: 13.318
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS50012	RCC1_3	coord: 1810..1861 score: 9.238
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS50012	RCC1_3	coord: 1645..1697 score: 12.916
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS50012	RCC1_3	coord: 1750..1809 score: 9.72
IPR000408	Regulator of chromosome condensation, RCC1	PROSITE	PS50012	RCC1_3	coord: 1699..1749 score: 12.454
IPR000569	HECT domain	SMART	SM00119	hect_3	coord: 2030..2370 e-value: 7.3E-43 score: 158.4
IPR000569	HECT domain	PFAM	PF00632	HECT	coord: 2086..2361 e-value: 3.4E-53 score: 181.1
IPR000569	HECT domain	PROSITE	PS50237	HECT	coord: 2032..2370 score: 43.222
IPR001680	WD40 repeat	SMART	SM00320	WD40_4	coord: 1192..1231 e-value: 0.0081 score: 25.4 coord: 1053..1092 e-value: 16.0 score: 9.4 coord: 1234..1272 e-value: 13.0 score: 10.0 coord: 1140..1185 e-value: 280.0 score: 1.5 coord: 871..910 e-value: 49.0 score: 6.3
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 1199..1240 score: 9.673
IPR015943	WD40/YVTN repeat-like-containing domain superfamily	GENE3D	G3DSA:2.130.10.10		coord: 1150..1323 e-value: 1.9E-13 score: 52.6
None	No IPR available	GENE3D	G3DSA:3.30.2410.10		coord: 2252..2364 e-value: 1.9E-23 score: 84.7
None	No IPR available	GENE3D	G3DSA:3.90.1750.10		coord: 2018..2251 e-value: 3.1E-34 score: 120.4
None	No IPR available	GENE3D	G3DSA:3.30.2160.10		coord: 2135..2216 e-value: 3.1E-34 score: 120.4
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 415..437
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 410..437
None	No IPR available	PANTHER	PTHR22870:SF338	HECT DOMAIN AND RLD 7	coord: 2202..2374
None	No IPR available	PANTHER	PTHR22870	REGULATOR OF CHROMOSOME CONDENSATION	coord: 2019..2131
None	No IPR available	PANTHER	PTHR22870	REGULATOR OF CHROMOSOME CONDENSATION	coord: 2202..2374
None	No IPR available	PANTHER	PTHR22870:SF338	HECT DOMAIN AND RLD 7	coord: 1571..1857
None	No IPR available	PANTHER	PTHR22870	REGULATOR OF CHROMOSOME CONDENSATION	coord: 1571..1857
None	No IPR available	PANTHER	PTHR22870:SF338	HECT DOMAIN AND RLD 7	coord: 2019..2131
IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	GENE3D	G3DSA:2.130.10.30		coord: 1489..1860 e-value: 3.4E-83 score: 281.5
IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	SUPERFAMILY	SSF50985	RCC1/BLIP-II	coord: 1489..1860
IPR017986	WD40-repeat-containing domain	PROSITE	PS50294	WD_REPEATS_REGION	coord: 1199..1240 score: 9.494
IPR036322	WD40-repeat-containing domain superfamily	SUPERFAMILY	SSF50978	WD40 repeat-like	coord: 831..1117
IPR036322	WD40-repeat-containing domain superfamily	SUPERFAMILY	SSF50978	WD40 repeat-like	coord: 1063..1279
IPR035983	HECT, E3 ligase catalytic domain	SUPERFAMILY	SSF56204	Hect, E3 ligase catalytic domain	coord: 2034..2359