S-adenosylmethionine decarboxylase proenzyme

Overview
NameS-adenosylmethionine decarboxylase proenzyme
Smed IDSMED30035923
Length (bp)1607
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of S-adenosylmethionine decarboxylase proenzyme (SMED30035923) t-SNE clustered cells

Violin plots show distribution of expression levels for S-adenosylmethionine decarboxylase proenzyme (SMED30035923) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of S-adenosylmethionine decarboxylase proenzyme (SMED30035923) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for S-adenosylmethionine decarboxylase proenzyme (SMED30035923) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30035923

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30035923h1SMcG0005297 dd_Smed_v4_1099_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30035923h1SMcG0005297 dd_Smed_v4_1099_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30035923h1SMcG0005297 dd_Smed_v4_1099_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30035923h1SMcG0005297 dd_Smed_v4_1099_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Human
Match: AMD1 (adenosylmethionine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:457])

HSP 1 Score: 235.728 bits (600), Expect = 1.418e-72
Identity = 143/331 (43.20%), Postives = 196/331 (59.21%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+    D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+        G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKI-------EGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Human
Match: AMD1 (adenosylmethionine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:457])

HSP 1 Score: 235.728 bits (600), Expect = 1.418e-72
Identity = 143/331 (43.20%), Postives = 196/331 (59.21%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+    D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+        G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKI-------EGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Human
Match: AMD1 (adenosylmethionine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:457])

HSP 1 Score: 233.417 bits (594), Expect = 4.627e-70
Identity = 143/330 (43.33%), Postives = 195/330 (59.09%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFV 1057
            +FFEG+EKLLE+WF+    D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+        G+ R D Q  + +D +  F  F 
Sbjct:    5 HFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKI-------EGFKRLDCQSAMFNDYNFVFTSFA 326
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Human
Match: AMD1 (adenosylmethionine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:457])

HSP 1 Score: 179.104 bits (453), Expect = 6.920e-52
Identity = 111/266 (41.73%), Postives = 155/266 (58.27%), Query Frame = 2 
Query:  284 LFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+        G+ R D Q  + +D +  F  F +
Sbjct:    1 MFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIF-PNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKI-------EGFKRLDCQSAMFNDYNFVFTSFAK 258
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Human
Match: AMD1 (adenosylmethionine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:457])

HSP 1 Score: 179.104 bits (453), Expect = 6.920e-52
Identity = 111/266 (41.73%), Postives = 155/266 (58.27%), Query Frame = 2 
Query:  284 LFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+        G+ R D Q  + +D +  F  F +
Sbjct:    1 MFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIF-PNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKI-------EGFKRLDCQSAMFNDYNFVFTSFAK 258
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Celegans
Match: smd-1 (S-adenosylmethionine decarboxylase proenzyme S-adenosylmethionine decarboxylase alpha chain S-adenosylmethionine decarboxylase beta chain [Source:UniProtKB/Swiss-Prot;Acc:O02655])

HSP 1 Score: 236.498 bits (602), Expect = 9.392e-73
Identity = 141/347 (40.63%), Postives = 209/347 (60.23%), Query Frame = 2 
Query:   59 TMKDFENQTNHIP---QEYFFEGSEKLLEIWF-NSDDNDC-DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEF-GKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPV---MPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFP-GASIDDFLFEPCGYSMNGLIVE-DKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQIS-DSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +  +F  QT+ +    +EYFFEG+EKLLE+WF +S  N+   LR IP+  I  +LD   C+I+    N+ +DSYVLSESSLF+S  R+ILKTCGTT LL AL  I++  G   G  + Q ++YSR+ F  P  QP +H++F AE+++ D+   V G+AY  G L  + W LY   + V     ++ D T E++M +LD + + KF +  ++DG D   +AGIDK+ P GA + D LF+PCGYSMN  + + D+Y TIH+TPEK FS+ SFETN  +       +K+L+ F P K + ++ + + S+   D+  +L        GY R + Q   +    L +A+FVR
Sbjct:    5 SATNFAVQTHPVKAPDEEYFFEGAEKLLELWFCSSTQNETRSLRIIPREEIDAMLDIARCKILHSKHNESIDSYVLSESSLFISDNRVILKTCGTTRLLAALPVIMQLAGAYAGLDQVQSVYYSRKNFLRPDLQPSLHKNFDAEVEYLDSFF-VDGHAYCLGSLKQDRWYLYTFHREVEFPAHKQPDHTLEILMSDLDEEVLHKFTKDYAVDGNDCFMRAGIDKIIPAGADVHDELFDPCGYSMNAYMNDTDQYATIHVTPEKAFSFASFETNQDLVCLYSQTRKVLQCFRPNKILMTVFANDISEKGKDAQQQLWD--RELPGYRRTNVQFVRLETETLVYAHFVR 348
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Fly
Match: SamDC (gene:FBgn0019932 transcript:FBtr0079994)

HSP 1 Score: 256.529 bits (654), Expect = 1.198e-80
Identity = 144/332 (43.37%), Postives = 198/332 (59.64%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFN-SDDNDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLY--------VTEKPVMPER-----WDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYF 1054
            +FFEG EKLLEIWF  S + D DLR+I +S    +L  VNCQIIS   ND +D++VLSESS+FVS+RR ILKTCGTT  L  L  +L+  +  G+     +FYSR+ F  P  Q   HQ F  E+ + D++    G +Y  G +N ECW LY        +T + +  E+      DQT E++M +LD + M  FY+    D   AT K+GID + P   IDDFLF+PCGYSMNG+  + +Y TIHITPE  FSYVSFETN A+ +Y  LI +++  F P KF+ ++ + +CS   ++  +L    S  + + R D Q C     +L FA +
Sbjct:    7 HFFEGVEKLLEIWFEESSNGDDDLRNISRSDWENVLSNVNCQIISTSKNDIIDAFVLSESSMFVSKRRWILKTCGTTTPLKCLGQLLKLAEANGYNVVADLFYSRKNFTRPEAQITPHQGFTEEVTYLDSIF-PNGRSYCLGSMNLECWYLYTFSRSDIKITPQLISDEKNVDSDPDQTIEILMQDLDPETMSIFYKNKFNDANGATVKSGIDTILPTMHIDDFLFDPCGYSMNGINDKGEYMTIHITPENQFSYVSFETNVALSNYRKLINQVINTFKPGKFIVTIFANKCSLAYETMKELEVEYSQGSHWKRTDMQCCNFPSYNLLFAQY 337
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Zebrafish
Match: amd1 (adenosylmethionine decarboxylase 1 [Source:ZFIN;Acc:ZDB-GENE-040426-760])

HSP 1 Score: 230.335 bits (586), Expect = 1.338e-70
Identity = 136/304 (44.74%), Postives = 186/304 (61.18%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDD---NDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERW-----DQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYR 985
            +FFEG+EKLLE+WF+  D      DLR+IP+    ++L+ V+C IIS    D  ++Y+LSESS+FVS+RR ILKTCGTT LL AL P+LE  +   GF   +  FYSR+ F  P  Q   H++F  E++ F +     G AY  GRLN +CW L+  E   +PE W     DQT E++M +LD   M +FY  + +   D T  +GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y +LI +++++F P KF+ +L   + S+     S   K  SYR
Sbjct:    7 HFFEGTEKLLEVWFSRQDEAKGTGDLRTIPRFEWDKLLENVHCLIISVTKTDKQEAYILSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDAIENFFYSRKNFMKPTHQEFPHRNFQEEVE-FLSQIFPNGAAYCMGRLNSDCWYLFTLE---LPEFWENKQADQTLEVLMSDLDPAVMDQFYMKDGVSANDVTRMSGIRDLIPGSVIDATMFNPCGYSMNGMKTDGTYWTIHITPEPEFSYVSFETNLSQTSYDELICRVVDVFKPGKFVTTLFVNQSSKCRSVFSSAQKLESYR 306
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Zebrafish
Match: amd1 (adenosylmethionine decarboxylase 1 [Source:ZFIN;Acc:ZDB-GENE-040426-760])

HSP 1 Score: 230.335 bits (586), Expect = 1.338e-70
Identity = 136/304 (44.74%), Postives = 186/304 (61.18%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDD---NDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERW-----DQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYR 985
            +FFEG+EKLLE+WF+  D      DLR+IP+    ++L+ V+C IIS    D  ++Y+LSESS+FVS+RR ILKTCGTT LL AL P+LE  +   GF   +  FYSR+ F  P  Q   H++F  E++ F +     G AY  GRLN +CW L+  E   +PE W     DQT E++M +LD   M +FY  + +   D T  +GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y +LI +++++F P KF+ +L   + S+     S   K  SYR
Sbjct:    7 HFFEGTEKLLEVWFSRQDEAKGTGDLRTIPRFEWDKLLENVHCLIISVTKTDKQEAYILSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDAIENFFYSRKNFMKPTHQEFPHRNFQEEVE-FLSQIFPNGAAYCMGRLNSDCWYLFTLE---LPEFWENKQADQTLEVLMSDLDPAVMDQFYMKDGVSANDVTRMSGIRDLIPGSVIDATMFNPCGYSMNGMKTDGTYWTIHITPEPEFSYVSFETNLSQTSYDELICRVVDVFKPGKFVTTLFVNQSSKCRSVFSSAQKLESYR 306
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Xenopus
Match: exosc2 (exosome component 2 [Source:Xenbase;Acc:XB-GENE-977773])

HSP 1 Score: 228.409 bits (581), Expect = 9.981e-70
Identity = 139/326 (42.64%), Postives = 192/326 (58.90%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDD---NDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+  D      DLR IP+    ++L+ V+C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+LE  +   GF   Q  FYSR+ F  P  Q   H++F  E++  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD + M +FY    +   D T  +GI  L  G+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN ++  Y DLI K++++F P KF+ +L   + S+   + S   K      G+ R D Q    +D +  F  F +
Sbjct:    9 HFFEGTEKLLEVWFSQQDESKGSGDLRDIPRFEWDKLLENVHCLIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDGIQNFFYSRKNFMKPDHQEYPHRNFQEEVEFLNQIFP-NGAAYCMGRINSDCWYLYTLDIPDGYVINQPDQTLEILMSELDPEVMDQFYMKEGVTANDVTRVSGIRDLITGSVIDATMFSPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNVSLTTYDDLISKVVDVFKPRKFVTTLFVNQSSKCRTAFSCAQKI----EGFRRLDRQFAQFNDYNFVFTSFAK 329
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Mouse
Match: Amd1 (S-adenosylmethionine decarboxylase 1 [Source:MGI Symbol;Acc:MGI:88004])

HSP 1 Score: 239.195 bits (609), Expect = 5.914e-74
Identity = 144/331 (43.50%), Postives = 198/331 (59.82%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Mouse
Match: Amd1 (S-adenosylmethionine decarboxylase 1 [Source:MGI Symbol;Acc:MGI:88004])

HSP 1 Score: 239.195 bits (609), Expect = 5.914e-74
Identity = 144/331 (43.50%), Postives = 198/331 (59.82%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Mouse
Match: Amd2 (S-adenosylmethionine decarboxylase 2 [Source:MGI Symbol;Acc:MGI:1333111])

HSP 1 Score: 236.498 bits (602), Expect = 5.085e-73
Identity = 143/331 (43.20%), Postives = 197/331 (59.52%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y  LI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDHLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Mouse
Match: Amd1 (S-adenosylmethionine decarboxylase 1 [Source:MGI Symbol;Acc:MGI:88004])

HSP 1 Score: 236.113 bits (601), Expect = 2.912e-71
Identity = 144/330 (43.64%), Postives = 197/330 (59.70%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFV 1057
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F 
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFA 326
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Mouse
Match: Amd1 (S-adenosylmethionine decarboxylase 1 [Source:MGI Symbol;Acc:MGI:88004])

HSP 1 Score: 140.969 bits (354), Expect = 9.168e-39
Identity = 86/186 (46.24%), Postives = 114/186 (61.29%), Query Frame = 2 
Query:  284 LFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVS 829
            +FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVS
Sbjct:    1 MFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVS 185
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. UniProt/SwissProt
Match: sp|P91931|DCAM_DROME (S-adenosylmethionine decarboxylase proenzyme OS=Drosophila melanogaster OX=7227 GN=SamDC PE=2 SV=1)

HSP 1 Score: 256.144 bits (653), Expect = 1.394e-79
Identity = 144/332 (43.37%), Postives = 198/332 (59.64%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFN-SDDNDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLY--------VTEKPVMPER-----WDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYF 1054
            +FFEG EKLLEIWF  S + D DLR+I +S    +L  VNCQIIS   ND +D++VLSESS+FVS+RR ILKTCGTT  L  L  +L+  +  G+     +FYSR+ F  P  Q   HQ F  E+ + D++    G +Y  G +N ECW LY        +T + +  E+      DQT E++M +LD + M  FY+    D   AT K+GID + P   IDDFLF+PCGYSMNG+  + +Y TIHITPE  FSYVSFETN A+ +Y  LI +++  F P KF+ ++ + +CS   ++  +L    S  + + R D Q C     +L FA +
Sbjct:    7 HFFEGVEKLLEIWFEESSNGDDDLRNISRSDWENVLSNVNCQIISTSKNDIIDAFVLSESSMFVSKRRWILKTCGTTTPLKCLGQLLKLAEANGYNVVADLFYSRKNFTRPEAQITPHQGFTEEVTYLDSIF-PNGRSYCLGSMNLECWYLYTFSRSDIKITPQLISDEKNVDSDPDQTIEILMQDLDPETMSIFYKNKFNDANGATVKSGIDTILPTMHIDDFLFDPCGYSMNGINDKGEYMTIHITPENQFSYVSFETNVALSNYRKLINQVINTFKPGKFIVTIFANKCSLAYETMKELEVEYSQGSHWKRTDMQCCNFPSYNLLFAQY 337
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. UniProt/SwissProt
Match: sp|P17708|DCAM_RAT (S-adenosylmethionine decarboxylase proenzyme OS=Rattus norvegicus OX=10116 GN=Amd1 PE=1 SV=3)

HSP 1 Score: 239.195 bits (609), Expect = 3.244e-73
Identity = 144/331 (43.50%), Postives = 198/331 (59.82%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDLPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. UniProt/SwissProt
Match: sp|P0DMN7|DCAM1_MOUSE (S-adenosylmethionine decarboxylase proenzyme 1 OS=Mus musculus OX=10090 GN=Amd1 PE=1 SV=1)

HSP 1 Score: 239.195 bits (609), Expect = 4.137e-73
Identity = 144/331 (43.50%), Postives = 198/331 (59.82%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. UniProt/SwissProt
Match: sp|P82185|DCAM2_MUSSP (S-adenosylmethionine decarboxylase proenzyme 2 OS=Mus spretus OX=10096 GN=Amd2 PE=3 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 4.651e-73
Identity = 144/331 (43.50%), Postives = 198/331 (59.82%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+       +G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNVIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------DGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. UniProt/SwissProt
Match: sp|P28918|DCAM_MESAU (S-adenosylmethionine decarboxylase proenzyme OS=Mesocricetus auratus OX=10036 GN=AMD1 PE=2 SV=1)

HSP 1 Score: 238.424 bits (607), Expect = 8.181e-73
Identity = 144/331 (43.50%), Postives = 197/331 (59.52%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDNDC-----DLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKP--VMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLI---SEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            +FFEG+EKLLE+WF+   +D      DLR+IP+S    +L  V C IIS    D  ++YVLSESS+FVS+RR ILKTCGTT LL AL P+L+  +   GF   Q  FYSR+ F  P+ Q   H++F  EI+  + +    G AY  GR+N +CW LY  + P   +  + DQT E++M  LD   M +FY  + +   D T ++GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y DLI+K++E+F P KF+ +L    S +C  +  S  K+        G+ R D Q  + +D +  F  F +
Sbjct:    5 HFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFP-NGAAYCMGRMNSDCWYLYTLDFPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKI-------EGFKRLDCQSAMFNDYNFVFTSFAK 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. TrEMBL
Match: A0A2C9LZK3 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106069419 PE=4 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 4.087e-88
Identity = 155/325 (47.69%), Postives = 208/325 (64.00%), Query Frame = 2 
Query:  101 EYFFEGSEKLLEIWFNSDDND--CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEF-GKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTL-TNVKGNAYTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            ++FFEG+EKLLEIWF S +ND  CDLR+I +    ++L  V C+IIS M ++ MDSYVLSESS+FV++ R ILKTCGTT LL A+K + +   K  G+     IFYSR+ F  P  Q  +HQ F  E+DH D + TN  G AY  GR+N +CW LY  E   + E+ DQT E++M ++   KM  F R  SIDG DAT K+GI  + PG  IDD+LF+PCGYSMNGL+    Y TIH+TPE   SYVSFETN     Y +L+KK+L++F P KF+ ++ +   S   D+H  + + +    GY+R D Q C + +  LT+  F R
Sbjct:    7 QHFFEGTEKLLEIWFTSSENDKSCDLRTIQRKDWEKLLKLVRCEIISFMKHEDMDSYVLSESSMFVTKNRFILKTCGTTTLLIAVKQLAQLVKKECGYDTIADIFYSRKNFSRPELQHYLHQSFDKEVDHLDQMFTN--GAAYVLGRMNKDCWYLYTLENGRV-EQPDQTLELLMWDMCRSKMEIFTRNQSIDGKDATKKSGICDIIPGIQIDDYLFDPCGYSMNGLLPGVYYITIHVTPEPHCSYVSFETNVPQASYQELLKKVLDVFKPGKFLMTVFANTASIAKDTHRHM-EHLDTIEGYMRSDHQFCSLKNYYLTYTQFSR 327
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. TrEMBL
Match: A0A0B7B9W9 (Uncharacterized protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF167460 PE=4 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 4.215e-88
Identity = 153/324 (47.22%), Postives = 209/324 (64.51%), Query Frame = 2 
Query:  101 EYFFEGSEKLLEIWFNSDDND--CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKI-LGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVR 1060
            ++FFEG+EKLLE+WF S  ND  CDLR+I +    ++L  V C+IIS M +D MDSYVLSESS+FV++ R ILKTCGTT LL A+K +++  K   GF     IFYSR+ F  P  Q  +HQ F  E+DH D + N  G AY  GR+N +CW LY  +   + E+ DQTFE++M  L  +KM+ F R    DG +AT ++GI  + PG  IDD+LFEPCGYSMNGL+    Y TIH+TPE   S+VSFE+N   + Y +LI+K+L++F P KF+ ++ + + S   DSH +L K +   +GY R D Q C     +LT+  + R
Sbjct:   12 QHFFEGTEKLLEVWFTSSTNDQTCDLRTIDRKDWEKLLKLVKCEIISFMKDDCMDSYVLSESSMFVTKNRFILKTCGTTTLLVAVKGLVQLVKRECGFDTLADIFYSRKNFARPELQHFMHQSFDKEVDHLDQMFN--GAAYVLGRMNKDCWYLYTRDSGGV-EQPDQTFELLMWELCPNKMKIFTRDVCADGKEATLRSGICDIIPGIKIDDYLFEPCGYSMNGLLPGGYYITIHVTPEPHCSFVSFESNVPQESYQNLIQKVLQVFNPGKFLMTVFANKASIARDSHKQLEK-VDTIDGYTRHDHQFCSFKSYNLTYTQYSR 331
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. TrEMBL
Match: A0A034W9U5 (S-adenosylmethionine decarboxylase proenzyme OS=Bactrocera dorsalis OX=27457 GN=DCAM PE=3 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 4.727e-88
Identity = 152/335 (45.37%), Postives = 206/335 (61.49%), Query Frame = 2 
Query:   95 PQEYFFEGSEKLLEIWFNSDDND-CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEK----PVMPERWD-----QTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNP 1066
            P  YFFEG EKLLEIWF  DDND CDLR IP++S   +L  V C+IIS   ND +D+YVLSESS+FVS++R ILKTCG+T LL +LKP+LE     GF E   +FYSR+ F  P  Q   H+ F  E+++ DT+   +G +Y  G +N ECW LY   K       P + D     QT E++M NLD D M KF +     GA+ T   GIDKL P   IDDFLF+PCGYSMNG+  + +Y TIHITPE  FSYVSFE+N ++ +Y +LI ++++ F P KF+ ++ + + S    +  +L    + +  + R + Q C     +L FA + + P
Sbjct:    9 PSVYFFEGVEKLLEIWFEDDDNDECDLRKIPRASWETLLQSVKCEIISFTKNDAIDAYVLSESSMFVSKKRWILKTCGSTTLLKSLKPLLELVPQYGFTEITDLFYSRKNFSRPELQAFPHRGFCEEVEYLDTVFE-EGRSYCLGSINRECWYLYTFSKYKKEVTRPRKLDNAEPDQTIEILMQNLDKDVMAKFSKDKYETGAEVTKATGIDKLLPNMIIDDFLFDPCGYSMNGIADKGEYMTIHITPESNFSYVSFESNVSMNNYAELINRVVKTFKPGKFVVTIFANKASPAYATIKELELEYAEKTSWKRSNMQYCSFPLYNLLFAQYCQCP 342
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. TrEMBL
Match: A0A0K8VQN0 (S-adenosylmethionine decarboxylase proenzyme OS=Bactrocera latifrons OX=174628 GN=SamDC_1 PE=3 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 6.252e-88
Identity = 152/335 (45.37%), Postives = 206/335 (61.49%), Query Frame = 2 
Query:   95 PQEYFFEGSEKLLEIWFNSDDND-CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEK----PVMPERWD-----QTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNP 1066
            P  YFFEG EKLLEIWF  DDND CDLR IP++S   +L  V C+IIS   ND +D+YVLSESS+FVS++R ILKTCG+T LL +LKP+LE     GF E   +FYSR+ F  P  Q   H+ F  E+++ DT+   +G +Y  G +N ECW LY   K       P + D     QT E++M NLD D M KF +     GA+ T   GIDKL P   IDDFLF+PCGYSMNG+  + +Y TIHITPE  FSYVSFE+N ++ +Y +LI ++++ F P KF+ ++ + + S    +  +L    + +  + R + Q C     +L FA + + P
Sbjct:    9 PSVYFFEGVEKLLEIWFEDDDNDECDLRKIPRASWETLLQSVKCEIISFTKNDAIDAYVLSESSMFVSKQRWILKTCGSTTLLKSLKPLLELVPQYGFTEITDLFYSRKNFSRPELQAFPHRGFCEEVEYLDTVFE-EGRSYCLGSINRECWYLYTFSKYKKEVTRPRKLDNAEPDQTIEILMQNLDKDVMAKFSKEKYETGAEVTKATGIDKLLPNMIIDDFLFDPCGYSMNGIADKGEYMTIHITPESNFSYVSFESNVSMNNYAELINRVVKTFKPGKFVVTIFANKASPAYATIKELELEYAEKTSWKRSNMQYCSFPLYNLLFAQYCQCP 342
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. TrEMBL
Match: A0A0A1XDF2 (S-adenosylmethionine decarboxylase proenzyme OS=Zeugodacus cucurbitae OX=28588 GN=SamDC PE=3 SV=1)

HSP 1 Score: 281.182 bits (718), Expect = 8.426e-87
Identity = 150/335 (44.78%), Postives = 206/335 (61.49%), Query Frame = 2 
Query:   95 PQEYFFEGSEKLLEIWFNSDDND-CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEK----PVMPERWD-----QTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNP 1066
            P  YFFEG EKLLEIWF  DDND CDLR IP+++   +L  V C+IIS   ND +D+YVLSESS+FVS++R ILKTCG+T LL +LKP+LE     GF E   +FYSR+ F  P  Q   H+ F  E+++ DT+   +G +Y  G +N ECW LY   K       P + D     QT E++M NLD + M KF +     GA+ T   GIDKL P   IDDFLF+PCGYSMNG+  + +Y TIHITPE  FSYVSFE+N ++ +Y +LI ++++ F P KF+ ++ + + S    +  +L    + +  + R + Q C     +L FA + + P
Sbjct:    9 PSVYFFEGVEKLLEIWFEDDDNDECDLRKIPRANWETLLQSVKCEIISFTKNDAIDAYVLSESSMFVSKKRWILKTCGSTTLLKSLKPLLELVPQYGFTEITDLFYSRKNFSRPELQAFPHRGFCEEVEYLDTVFE-EGRSYCLGSINRECWYLYTFSKYKKEVTRPRKLDNSEPDQTIEILMQNLDNEVMGKFSKEKYETGAEVTKATGIDKLLPNMVIDDFLFDPCGYSMNGIADKGEYMTIHITPESNFSYVSFESNVSMNNYAELINRVVKTFKPGKFVVTIFANKASPAYATIKELELEYAEKTSWKRSNMQYCSFPLYNLLFAQYCQCP 342
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Cavefish
Match: amd1 (adenosylmethionine decarboxylase 1 [Source:ZFIN;Acc:ZDB-GENE-040426-760])

HSP 1 Score: 199.134 bits (505), Expect = 5.063e-59
Identity = 122/282 (43.26%), Postives = 167/282 (59.22%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDD---NDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERW-----DQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSL 919
            +FFEG+EKLLE+WF+  D      DLR+IP+    ++L+ V+C IIS    D  ++Y+LSESS+FVS+RR ILKTCGTT LL AL P+LE  +   GF   +  FYSR+ F  P  Q   H++F  E++ F +     G AY  GRLN +CW L+  E   +PE W     DQT E++M +LD   M +FY  + +   D T  +GI  L PG+ ID  +F PCGYSMNG+  +  Y+TIHITPE  FSYV                 ++++F P KF+ +L
Sbjct:    7 HFFEGTEKLLEVWFSRQDETKGTGDLRTIPRFEWDKLLENVHCLIISVTKTDKQEAYILSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYSGFDTIENFFYSRKNFMKPTHQEFPHRNFEEEVE-FLSQIFPNGAAYCMGRLNSDCWYLFTLE---LPEYWENKQADQTLEVLMSDLDPAVMDQFYMKDGVSANDVTRMSGIRDLIPGSVIDATMFNPCGYSMNGMKTDGTYWTIHITPEPEFSYV-----------------IVDVFKPGKFVTTL 267
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Yeast
Match: SPE2 (S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically [Source:SGD;Acc:S000005412])

HSP 1 Score: 144.821 bits (364), Expect = 6.487e-39
Identity = 112/327 (34.25%), Postives = 171/327 (52.29%), Query Frame = 2 
Query:  110 FEGSEKLLEIWF----NSDDNDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTT---FLLNALKPILE------FGKILG--FQEYQIFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDEC--WNLYVTEKPVMPERW-------DQTFEMIMMNLDLDKMRKFY-----------RINSIDGAD----ATSKAGIDKLFPGASIDD--------FLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAV-------KDYIDLIKKLLEMFGPEKFMFSLISE 928
            FEG EKLLEIWF     S   +  LR+I     +EIL  V C+++S      +D+++LSESSLFV   ++ +KTCGTT   F L  L  I+E      F    G  ++ +++FYSRR F +P  Q  +HQ++  E+D+ +   +  G +Y+ GR ND+   WNLYVTE      +        D+TFE++M  LD +   KF              N   G +     T    +D+++  ++ D         F F PCGYS N ++ E  Y+T+H+TPEKG+SY SFE+N  V       +D +D++  +L +F P +F  +  ++
Sbjct:   28 FEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFD-NGKSYSVGR-NDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTK 352
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Nematostella
Match: EDO36391 (S-adenosylmethionine decarboxylase proenzyme [Source:UniProtKB/TrEMBL;Acc:A7SIS5])

HSP 1 Score: 242.276 bits (617), Expect = 1.536e-75
Identity = 146/337 (43.32%), Postives = 195/337 (57.86%), Query Frame = 2 
Query:  107 FFEGSEKLLEIWF----------------NSDDNDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEF-GKILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEE---CSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYF 1054
            FFEG EKLLEIW+                N      DLR IP+    +IL  VNCQIISE  N+ M SY+LSESS+F+S+ RIILKTCGTT LL ++KP+L    +  G    Q +FYSR  +  P  Q  +H+ F  E+   D L    G AY+ GR+N + W  Y   +  + E+ DQT E++M +LD + M+ FY     + ++ T   GI    PGA IDDFLF+PCGYSMNGL   D YFTIHITP+K  SYVSFETN  VK Y +L+ K+L+ F P +F+ +L + E   C     +  +LG      +GY R D Q C +   +LT+ ++
Sbjct:    6 FFEGPEKLLEIWWRPTLATESILRNRGKCNKMAKKGDLREIPRQKWEKILQLVNCQIISEKRNEDMISYLLSESSMFISKERIILKTCGTTTLLYSIKPLLNLAAEECGLTIVQDLFYSRMNYLKPDMQKDLHRSFEKEVQWLDKLF-ANGAAYSLGRVNGDSWYFYTLRQQGV-EQPDQTLEILMQDLDPNVMKAFYTGQYANVSEVTKATGIADFIPGAIIDDFLFDPCGYSMNGLF-GDNYFTIHITPQKECSYVSFETNIRVKCYKELVNKVLKAFKPGRFLMTLFANEGAPCGPSLKTFQELG-----FHGYQRWDLQLCQMKYYNLTYGHY 334
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Medaka
Match: amd1 (adenosylmethionine decarboxylase 1 [Source:NCBI gene;Acc:101168260])

HSP 1 Score: 242.662 bits (618), Expect = 1.868e-75
Identity = 145/333 (43.54%), Postives = 201/333 (60.36%), Query Frame = 2 
Query:  104 YFFEGSEKLLEIWFNSDDND---CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGK-ILGFQEYQ-IFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERW-----DQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEE---CSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRN 1063
            +FFEG+EKLLE+WF   D+     DLRSIP+    ++L+ V+C IIS    D  ++Y+LSESS+FVS+RR ILKTCGTT LL AL P+LE  +   GF   +  FYSR+ F  PA Q   H++F  E+D    +    G AY  GRLN +CW L+  +   +PE W     DQT E++M +LD   M +FY  + +  +D T  +GI  L PG+ ID  LF PCGYSMNG+  +  Y+TIHITPE  FSYVSFETN +   Y +L++K++E+F P KF+ +L   +   C  +  S+ KL       +GY R D Q    +D +  F+ + +N
Sbjct:   11 HFFEGTEKLLEVWFCRQDDTKGTGDLRSIPRFEWDKLLENVHCLIISVTKTDKQEAYILSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDSIENFFYSRKNFMKPAHQEFPHRNFQEEVDFLSQIF-PNGAAYCMGRLNSDCWYLFTLD---LPEYWENNQADQTLEVLMSDLDPAIMDQFYMKDGVSASDVTRMSGIRDLIPGSVIDATLFNPCGYSMNGMKTDGTYWTIHITPEPEFSYVSFETNLSQTSYDELVRKVVEVFKPGKFVTTLFVNQRSKCRSVFSSNQKL-------DGYKRLDRQLAQFNDYNFVFSSYTKN 332
[Close]
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Planmine SMEST
Match: SMESG000011356.1 (SMESG000011356.1)

HSP 1 Score: 696.812 bits (1797), Expect = 0.000e+0
Identity = 335/336 (99.70%), Postives = 336/336 (100.00%), Query Frame = 2 
Query:   62 MKDFENQTNHIPQEYFFEGSEKLLEIWFNSDDNDCDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQIFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNPG 1069
            MKDFENQTNHIPQEYFFEGSEKLLEIWFNSDDN+CDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQIFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNPG
Sbjct:    1 MKDFENQTNHIPQEYFFEGSEKLLEIWFNSDDNECDLRSIPKSSIVEILDKVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPILEFGKILGFQEYQIFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNAYTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSIDGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEKGFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSKLGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNPG 336
The following BLAST results are available for this feature:
BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
AMD11.418e-7243.20adenosylmethionine decarboxylase 1 [Source:HGNC Sy... [more]
AMD11.418e-7243.20adenosylmethionine decarboxylase 1 [Source:HGNC Sy... [more]
AMD14.627e-7043.33adenosylmethionine decarboxylase 1 [Source:HGNC Sy... [more]
AMD16.920e-5241.73adenosylmethionine decarboxylase 1 [Source:HGNC Sy... [more]
AMD16.920e-5241.73adenosylmethionine decarboxylase 1 [Source:HGNC Sy... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
smd-19.392e-7340.63S-adenosylmethionine decarboxylase proenzyme S-ade... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
SamDC1.198e-8043.37gene:FBgn0019932 transcript:FBtr0079994[more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
amd11.338e-7044.74adenosylmethionine decarboxylase 1 [Source:ZFIN;Ac... [more]
amd11.338e-7044.74adenosylmethionine decarboxylase 1 [Source:ZFIN;Ac... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
exosc29.981e-7042.64exosome component 2 [Source:Xenbase;Acc:XB-GENE-97... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Amd15.914e-7443.50S-adenosylmethionine decarboxylase 1 [Source:MGI S... [more]
Amd15.914e-7443.50S-adenosylmethionine decarboxylase 1 [Source:MGI S... [more]
Amd25.085e-7343.20S-adenosylmethionine decarboxylase 2 [Source:MGI S... [more]
Amd12.912e-7143.64S-adenosylmethionine decarboxylase 1 [Source:MGI S... [more]
Amd19.168e-3946.24S-adenosylmethionine decarboxylase 1 [Source:MGI S... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P91931|DCAM_DROME1.394e-7943.37S-adenosylmethionine decarboxylase proenzyme OS=Dr... [more]
sp|P17708|DCAM_RAT3.244e-7343.50S-adenosylmethionine decarboxylase proenzyme OS=Ra... [more]
sp|P0DMN7|DCAM1_MOUSE4.137e-7343.50S-adenosylmethionine decarboxylase proenzyme 1 OS=... [more]
sp|P82185|DCAM2_MUSSP4.651e-7343.50S-adenosylmethionine decarboxylase proenzyme 2 OS=... [more]
sp|P28918|DCAM_MESAU8.181e-7343.50S-adenosylmethionine decarboxylase proenzyme OS=Me... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2C9LZK34.087e-8847.69Uncharacterized protein OS=Biomphalaria glabrata O... [more]
A0A0B7B9W94.215e-8847.22Uncharacterized protein (Fragment) OS=Arion vulgar... [more]
A0A034W9U54.727e-8845.37S-adenosylmethionine decarboxylase proenzyme OS=Ba... [more]
A0A0K8VQN06.252e-8845.37S-adenosylmethionine decarboxylase proenzyme OS=Ba... [more]
A0A0A1XDF28.426e-8744.78S-adenosylmethionine decarboxylase proenzyme OS=Ze... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
amd15.063e-5943.26adenosylmethionine decarboxylase 1 [Source:ZFIN;Ac... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
SPE26.487e-3934.25S-adenosylmethionine decarboxylase; required for t... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO363911.536e-7543.32S-adenosylmethionine decarboxylase proenzyme [Sou... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
amd11.868e-7543.54adenosylmethionine decarboxylase 1 [Source:NCBI ge... [more]
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BLAST of S-adenosylmethionine decarboxylase proenzyme vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000011356.10.000e+099.70SMESG000011356.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30035923 ID=SMED30035923|Name=S-adenosylmethionine decarboxylase proenzyme|organism=Schmidtea mediterranea sexual|type=transcript|length=1607bp
TTTTTATTTTAAGTGGCTTGAAACTGAGAGGTGATATTTAAGTGGGATTC
AATTCCAAACTATGAAAGATTTTGAAAACCAAACCAATCATATTCCACAG
GAATATTTTTTTGAAGGCAGTGAAAAGTTGTTAGAAATATGGTTTAACTC
GGATGATAATGATTGCGATTTGCGATCCATTCCTAAAAGCTCCATCGTTG
AAATTCTTGATAAAGTTAATTGTCAGATCATTTCAGAGATGTCTAATGAT
TATATGGATTCTTATGTTTTAAGTGAGAGCAGTTTGTTCGTCTCTCAAAG
AAGAATAATTCTTAAAACTTGTGGCACAACATTTTTATTAAATGCTTTAA
AACCCATTTTAGAATTTGGCAAAATTTTAGGATTTCAAGAATACCAAATA
TTTTATTCTCGTCGACGATTTGAATATCCTGCCTGTCAACCATTGGTCCA
TCAAGACTTTTTTGCTGAAATTGATCATTTCGATACTCTTACTAACGTCA
AAGGAAATGCTTACACTTTTGGTCGATTAAACGATGAGTGCTGGAATCTG
TACGTCACTGAAAAACCAGTAATGCCTGAAAGATGGGATCAAACATTCGA
GATGATTATGATGAATTTGGATTTGGATAAAATGCGCAAATTCTATCGAA
TTAATAGTATTGACGGGGCGGATGCTACAAGCAAAGCTGGAATAGACAAA
CTCTTTCCCGGTGCATCAATTGATGATTTTCTATTTGAGCCATGCGGTTA
TTCAATGAACGGGCTCATTGTTGAGGATAAGTATTTCACGATTCACATAA
CACCGGAAAAGGGTTTTTCTTACGTCAGTTTTGAAACTAATTACGCCGTA
AAAGATTACATAGATCTAATCAAGAAGCTTTTGGAAATGTTTGGGCCGGA
AAAATTTATGTTTAGCTTGATTTCGGAAGAGTGCTCTCAGATTTCGGATA
GCCACAGCAAACTTGGCAAGTCCATTAGTTATAGGAACGGCTACTTGCGT
AAAGATTGGCAGCGATGTGTTGTTTCTGATTTAGATCTCACCTTCGCCTA
TTTTGTCCGTAACCCAGGCTAGGAAATAATGGGTGGGTATACTGCTTCAC
GGCAGTTACCCGCCCAATACAAACTGGTTCTAGCCAGTGGGCAACAACAT
TTTACTCTTTTATTTGTCGTTATATTTTTATCGCTAATAAATCAAAATGA
ACTGATGGAATGTTGTTGTTGTGTTAATGACTCTGATCGATTTCATAAGT
GTGACAGTTGCAGTAGTCTGATCTTTCGTGTAAGCAGCGCTCGCTGGTAT
AGGTGTGTTCTGAGGGTTTCATTGCCCGTGTCTAAGAGATTCTGTAATTG
GATTAGATTTAAATGTACCTATGTTTGGTGCGGTCAGACCTGTTACTCGA
TTTTATGACACCGCTTATCGGTGACGGTTTTTACCACGCTGTGTTTTCGG
TGCTCAATCGAGATTATGTGATTGGATTTCCTTATGATGTTCATTTTGAT
TGTTATTTTCCTTTTTGTTTGCGCTTATTTTTATTTATACTTTTAGAAAT
ATATGTTGTGTAGTTTTGTTTTTATTTCAATGAATTATATCTTATGCCTG
AAAAAAA
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protein sequence of SMED30035923-orf-1

>SMED30035923-orf-1 ID=SMED30035923-orf-1|Name=SMED30035923-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=337bp
MKDFENQTNHIPQEYFFEGSEKLLEIWFNSDDNDCDLRSIPKSSIVEILD
KVNCQIISEMSNDYMDSYVLSESSLFVSQRRIILKTCGTTFLLNALKPIL
EFGKILGFQEYQIFYSRRRFEYPACQPLVHQDFFAEIDHFDTLTNVKGNA
YTFGRLNDECWNLYVTEKPVMPERWDQTFEMIMMNLDLDKMRKFYRINSI
DGADATSKAGIDKLFPGASIDDFLFEPCGYSMNGLIVEDKYFTIHITPEK
GFSYVSFETNYAVKDYIDLIKKLLEMFGPEKFMFSLISEECSQISDSHSK
LGKSISYRNGYLRKDWQRCVVSDLDLTFAYFVRNPG*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR016067S-AdoMet_deCO2ase_core
IPR001985S-AdoMet_decarboxylase
IPR018167S-AdoMet_decarboxylase_subgr
IPR018166S-AdoMet_deCO2ase_CS
Vocabulary: molecular function
TermDefinition
GO:0004014adenosylmethionine decarboxylase activity
GO:0016829lyase activity
GO:0016831carboxy-lyase activity
Vocabulary: biological process
TermDefinition
GO:0008295spermidine biosynthetic process
GO:0006597spermine biosynthetic process
GO:0006557S-adenosylmethioninamine biosynthetic process
GO:0006596polyamine biosynthetic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001985S-adenosylmethionine decarboxylasePIRSFPIRSF001355SAM_decarbox_eukcoord: 2..335
e-value: 8.2E-108
score: 358.1
IPR001985S-adenosylmethionine decarboxylasePFAMPF01536SAM_decarboxcoord: 15..331
e-value: 4.3E-102
score: 341.8
IPR001985S-adenosylmethionine decarboxylaseTIGRFAMTIGR00535TIGR00535coord: 17..307
e-value: 6.6E-86
score: 286.2
IPR001985S-adenosylmethionine decarboxylasePANTHERPTHR11570S-ADENOSYLMETHIONINE DECARBOXYLASEcoord: 13..334
NoneNo IPR availableGENE3DG3DSA:3.60.90.10coord: 12..335
e-value: 4.8E-107
score: 359.8
NoneNo IPR availablePANTHERPTHR11570:SF0S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYMEcoord: 13..334
IPR018166S-adenosylmethionine decarboxylase, conserved sitePROSITEPS01336ADOMETDCcoord: 67..77
IPR016067S-adenosylmethionine decarboxylase, coreSUPERFAMILYSSF56276S-adenosylmethionine decarboxylasecoord: 15..332