noggin-like protein 7

Overview


Name	noggin-like protein 7 (ACO06232.1)
Smed ID	SMED30035881
Length (bp)	1496

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of noggin-like protein 7 (SMED30035881) t-SNE clustered cells

Violin plots show distribution of expression levels for noggin-like protein 7 (SMED30035881) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of noggin-like protein 7 (SMED30035881) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for noggin-like protein 7 (SMED30035881) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30035881

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
cephalic ganglia	SMED30035881	SMESG000016086.1	dd_Smed_v4_10469_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30035881	SMESG000016086.1	dd_Smed_v4_10469_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30035881	SMESG000016086.1	Contig42555	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30035881	SMESG000016086.1	Contig42555	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
gut	SMED30035881	SMESG000016086.1	FJ471489.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
ventral region of the whole animal	SMED30035881	SMESG000016086.1	FJ471489.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
body wall musculature	SMED30035881	SMESG000016086.1	FJ471489.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
gut	SMED30035881	SMESG000016086.1	FJ471489	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
ventral region of the whole animal	SMED30035881	SMESG000016086.1	FJ471489	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
body wall musculature	SMED30035881	SMESG000016086.1	FJ471489	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
muscle cell	SMED30035881	SMESG000016086.1	dd_Smed_v4_10469_0_1	dd_Smed_v4	PMID:30962434 Cote et al., 2019

Note: Hover over icons to view figure legend

Homology

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BLAST of noggin-like protein 7 vs. Ensembl Human
Match: NOG (noggin [Source:HGNC Symbol;Acc:HGNC:7866])

HSP 1 Score: 65.0846 bits (157), Expect = 2.566e-11
Identity = 31/88 (35.23%), Postives = 47/88 (53.41%), Query Frame = 1

Query:  763 VGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            +  L F+   + G    + + ++   + WL   + C + + W DLG  FWP +++ G C S +SCS P GM CK S S  L +LRW C
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 7 vs. Ensembl Zebrafish
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 79.7221 bits (195), Expect = 1.021e-16
Identity = 52/167 (31.14%), Postives = 76/167 (45.51%), Query Frame = 1

Query:  526 PDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            P EQD + K  +K +G N  ANF S                     HL  Q  +   P++ R  MP E           +  L+ T     G  +++ +  +  F +WL  Y+ C + + W+DLG  FWP +I+ G C S +SCS+P GM+CK   + T   LRW C
Sbjct:   52 PREQDLSEKTLLKKLGSNFDANFMS--------------------IHLPAQLNASAPPELPRLPMPAE-----------LKKLDLT-ETPYGRRVKVGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFSERSCSFPEGMSCKPVKAVTKTFLRWYC 186

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BLAST of noggin-like protein 7 vs. Ensembl Zebrafish
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 71.2478 bits (173), Expect = 1.004e-13
Identity = 43/121 (35.54%), Postives = 61/121 (50.41%), Query Frame = 1

Query:  667 LDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCL 1029
            LD Q L +N    L G+MP           K + NL+F      G   +  + ++   + WL  YS C + + W DLG  FWP ++R G C + +SCS P GM CK + S  + LLRW C+
Sbjct:   86 LDEQELQLN----LAGMMP-----------KDIKNLDFD--APWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTKRSCSVPEGMVCKPAKSTHITLLRWRCV 189

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 68.1662 bits (165), Expect = 1.229e-12
Identity = 28/69 (40.58%), Postives = 41/69 (59.42%), Query Frame = 1

Query:  847 WLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEA 1053
            WL  Y+ C +   W+DLG  FWP +++ G C + +SCS P GM CK + S  L +LRW C++   G + 
Sbjct:  136 WLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLKC 204

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 68.1662 bits (165), Expect = 1.241e-12
Identity = 28/69 (40.58%), Postives = 41/69 (59.42%), Query Frame = 1

Query:  847 WLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEA 1053
            WL  Y+ C +   W+DLG  FWP +++ G C + +SCS P GM CK + S  L +LRW C++   G + 
Sbjct:  136 WLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLKC 204

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Query:  847 WLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEA 1053
            WL  Y+ C +   W+DLG  FWP +++ G C + +SCS P GM CK + S  L +LRW C++   G + 
Sbjct:  136 WLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLKC 204

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BLAST of noggin-like protein 7 vs. Ensembl Xenopus
Match: nog4 (noggin 4 [Source:NCBI gene;Acc:733455])

HSP 1 Score: 77.0258 bits (188), Expect = 2.854e-15
Identity = 44/126 (34.92%), Postives = 64/126 (50.79%), Query Frame = 1

Query:  670 DTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSS-KSCSWPSGMACKHSGSRTLHLLRWVC-LKDTN 1041
            DT  LS    D+  G     +  A++      G+L      S  + L +    QN  R+WL++ +SCQ+   W DLG +FWP W+R   C  +  +CSWP GMAC+ +    + LL W C +KDT 
Sbjct:   99 DTSLLSTLSQDLYDGASRYRKKLAQEAQALDFGSLQLPRELSANSSLHV----QNEIRQWLVQRASCQLTSTWVDLGTVFWPRWVRHTDCDGANTACSWPPGMACRQAQLTQIKLLAWHCWMKDTG 220

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BLAST of noggin-like protein 7 vs. Ensembl Xenopus
Match: acad10 (acyl-CoA dehydrogenase family member 10 [Source:Xenbase;Acc:XB-GENE-967980])

HSP 1 Score: 72.4034 bits (176), Expect = 5.791e-14
Identity = 53/167 (31.74%), Postives = 76/167 (45.51%), Query Frame = 1

Query:  526 PDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            P EQD + +   K +G N   NF S   PN                ++ TQ  S+ K   L G +P+E           +  L+ +     G  + + +  +  F +WL  Y+ C + + W+DLG  FWP +I+ G C S KSCS+P GM CK   S T   LRW C
Sbjct:   54 PKEQDLDERTLRKKLGSNFDPNFMSVVLPN--------------SVNMSTQ-DSLTKMKTL-GSVPLE-----------LKKLDLS-ETPYGGRIRMGKKARRKFLQWLWAYTYCPVMYTWKDLGVRFWPRFIKEGHCFSEKSCSFPEGMYCKPIKSVTKTFLRWYC 192

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BLAST of noggin-like protein 7 vs. Ensembl Xenopus
Match: nog (noggin [Source:NCBI gene;Acc:493191])

HSP 1 Score: 64.6994 bits (156), Expect = 2.442e-11
Identity = 39/127 (30.71%), Postives = 65/127 (51.18%), Query Frame = 1

Query:  664 HLDTQWLSINKPDVLRGLMPVEQINA--RQELMKA----VGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            H D  +++IN P+   G+  + +++   RQ+   A    +  L F +    G    + + ++   + WL   + C + + W DLG  FWP +++ G C S +SCS P GM CK + S  L +LRW C
Sbjct:   72 HFDPNFMAINLPEERLGVEDLGELDLLLRQKPSGAMPAEIKGLEF-YEGLQGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKRSCSVPEGMVCKAAKSMHLTILRWRC 197

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BLAST of noggin-like protein 7 vs. Ensembl Mouse
Match: Nog (noggin [Source:MGI Symbol;Acc:MGI:104327])

HSP 1 Score: 65.0846 bits (157), Expect = 1.681e-11
Identity = 31/88 (35.23%), Postives = 47/88 (53.41%), Query Frame = 1

Query:  763 VGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            +  L F+   + G    + + ++   + WL   + C + + W DLG  FWP +++ G C S +SCS P GM CK S S  L +LRW C
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 7 vs. UniProt/SwissProt
Match: sp|Q9W740|NOGG2_DANRE (Noggin-2 OS=Danio rerio OX=7955 GN=nog2 PE=2 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 7.709e-16
Identity = 52/167 (31.14%), Postives = 76/167 (45.51%), Query Frame = 1

Query:  526 PDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            P EQD + K  +K +G N  ANF S                     HL  Q  +   P++ R  MP E           +  L+ T     G  +++ +  +  F +WL  Y+ C + + W+DLG  FWP +I+ G C S +SCS+P GM+CK   + T   LRW C
Sbjct:   52 PREQDLSEKTLLKKLGSNFDANFMS--------------------IHLPAQLNASAPPELPRLPMPAE-----------LKKLDLT-ETPYGRRVKVGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFSERSCSFPEGMSCKPVKAVTKTFLRWYC 186

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BLAST of noggin-like protein 7 vs. UniProt/SwissProt
Match: sp|Q9W741|NOGG1_DANRE (Noggin-1 OS=Danio rerio OX=7955 GN=nog1 PE=2 SV=1)

HSP 1 Score: 71.633 bits (174), Expect = 6.151e-13
Identity = 43/121 (35.54%), Postives = 61/121 (50.41%), Query Frame = 1

Query:  667 LDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCL 1029
            LD Q L +N    L G+MP           K + NL+F      G   +  + ++   + WL  YS C + + W DLG  FWP ++R G C + +SCS P GM CK + S  + LLRW C+
Sbjct:   86 LDEQELQLN----LAGMMP-----------KDIKNLDFD--APWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTKRSCSVPEGMVCKPAKSTHITLLRWRCV 189

[Close]

BLAST of noggin-like protein 7 vs. UniProt/SwissProt
Match: sp|Q9YHT8|NOGG_TAKRU (Noggin OS=Takifugu rubripes OX=31033 GN=nog PE=3 SV=1)

HSP 1 Score: 71.633 bits (174), Expect = 7.352e-13
Identity = 31/69 (44.93%), Postives = 41/69 (59.42%), Query Frame = 1

Query:  838 FRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNG 1044
             ++WL  YS C +   W DLG  FWP ++R G C S +SCS P GM CK + S  L +LRW C++   G
Sbjct:  133 LQQWLWAYSFCPLAHAWTDLGSRFWPRFVRAGSCLSKRSCSVPEGMTCKPATSTHLTILRWRCVQRKVG 201

[Close]

BLAST of noggin-like protein 7 vs. UniProt/SwissProt
Match: sp|Q9YHV3|NOGG3_DANRE (Noggin-3 OS=Danio rerio OX=7955 GN=nog3 PE=1 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 1.487e-11
Identity = 28/69 (40.58%), Postives = 40/69 (57.97%), Query Frame = 1

Query:  847 WLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEA 1053
            WL  Y+ C +   W+DLG  FWP +++ G C + +SCS P GM CK   S  L +LRW C++   G + 
Sbjct:  136 WLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPPKSSHLTVLRWRCVQRKGGLKC 204

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BLAST of noggin-like protein 7 vs. UniProt/SwissProt
Match: sp|P97466|NOGG_MOUSE (Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 1.176e-10
Identity = 31/88 (35.23%), Postives = 47/88 (53.41%), Query Frame = 1

Query:  763 VGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            +  L F+   + G    + + ++   + WL   + C + + W DLG  FWP +++ G C S +SCS P GM CK S S  L +LRW C
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 7 vs. TrEMBL
Match: C1JAC7 (Noggin-like protein 7 OS=Schmidtea mediterranea OX=79327 GN=nlg7 PE=2 SV=1)

HSP 1 Score: 587.8 bits (1514), Expect = 0.000e+0
Identity = 303/303 (100.00%), Postives = 303/303 (100.00%), Query Frame = 1

Query:  391 FASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK 1299
            FASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQMLYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK
Sbjct:   11 FASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQMLYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK 313

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BLAST of noggin-like protein 7 vs. TrEMBL
Match: C1JAC8 (Noggin-like protein 8 OS=Schmidtea mediterranea OX=79327 GN=nlg8 PE=2 SV=1)

HSP 1 Score: 190.66 bits (483), Expect = 8.848e-53
Identity = 106/287 (36.93%), Postives = 166/287 (57.84%), Query Frame = 1

Query:  460 KAKVKLSDVMNEK------RRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTS--SKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQC 1296
            KA VK+S+V+  K      +  +   WP    DK  K+ ++++G NI     +N +P +  +N K+L++L  +   DT W SI+ P  L+      +     +L  A   LN TF D  G    +PE++  +FR WL++ ++C M+++WEDLG +FWP WIRRG+C +  ++SCSWP GM C+ SGSR LH+L W C +D N  E     N + + ++++  K+     +RRRR+P+    NN   +    K+  R+ ++ S AS+GY+C+W + KY INDKCSC C
Sbjct:   32 KANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKRLLHEKR-DTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREF----NRRKQRESRERNKRRWTKTRRRRRYPNEKTFNN---QENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSC 310

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BLAST of noggin-like protein 7 vs. TrEMBL
Match: A0A4S2M4R3 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_003970 PE=4 SV=1)

HSP 1 Score: 160.999 bits (406), Expect = 1.074e-40
Identity = 87/280 (31.07%), Postives = 147/280 (52.50%), Query Frame = 1

Query:  517 SWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPD-----VLRGLMPVEQINARQELMKAVGNLNFTFV-DSVGAMLEIPENMQN----LFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFP----DSTRSNNLSKEVQSKKKATRITRL-----LSRASDGYFCQWSMLKYYINDKCSCQCK 1299
            SWPP+   +  ++ ++++G+ I +    + +P+    + +KL K+     L +QW+S+  P        R ++ +        L+KAVG LNFT +  S G  + +P  M +    L + WL++ +SC++++VWEDLG +FWP WIRRG+C ++ +CSWP GM C+ SGSR L LLRWVC  D+N T+    +                   +RR  +P       R   L +    +++            LS  ++GY+C+WS  +Y ++D+C+C C+
Sbjct:  144 SWPPENSQEFARVDVRVMGERIDSVALLHLRPSSNAESTRKLRKILGS-DLQSQWMSVEPPPKDSERTSRSVVTMSMPQQDDRLLKAVGELNFTVLRSSPGTDMVVPVEMTHDQIELVKAWLVQRASCRLDYVWEDLGPLFWPRWIRRGICMNTMACSWPPGMLCRPSGSRQLKLLRWVCKNDSNPTDDDPQKR------------------RRRHEYPFYYKRYKREGPLLRRRIPREERRSRRVRRLIRKLSLTANGYYCEWSRHEYVVSDQCACGCE 404

[Close]

BLAST of noggin-like protein 7 vs. TrEMBL
Match: G7YQS9 (Noggin-3 OS=Clonorchis sinensis OX=79923 GN=CLF_107558 PE=4 SV=1)

HSP 1 Score: 160.999 bits (406), Expect = 1.097e-40
Identity = 89/280 (31.79%), Postives = 150/280 (53.57%), Query Frame = 1

Query:  517 SWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPD-----VLRGLMPVEQINARQELMKAVGNLNFTFV-DSVGAMLEIPENMQN----LFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFP----DSTRSNNLSKEVQSKKKATRITRL-----LSRASDGYFCQWSMLKYYINDKCSCQCK 1299
            SWPP+   +  ++ ++++G+ I +    + +P+    + +KL K+     L +QW+S++ P        R ++ +        L+KAVG LNFT +  S G  + +P  M +    L + WL++ +SC++++VWEDLG +FWP WIRRG+C ++ +CSWP GM C+ SGSR L LLRWVC  D+N T+   LQ                  ++RR  +P       R   L +    +++            LS  ++GY+C+WS  +Y ++D+C+C C+
Sbjct:  145 SWPPENSQEFARVDVRVMGERIDSVALLHLRPSSNAESIRKLRKILGS-DLQSQWMSVDPPPKDPERTSRSVVTMSMPQQDDRLLKAVGELNFTVLRPSPGTDMVVPVEMTHDQIELVKAWLVQRASCRLDYVWEDLGPLFWPRWIRRGICMNTMACSWPPGMLCRPSGSRQLKLLRWVCKNDSNPTD-DDLQK-----------------RRRRHEYPFYYKRYKREGPLLRRRIPREERRSRRVRRLIRKLSLTANGYYCEWSRHEYVVSDQCACGCE 405

[Close]

BLAST of noggin-like protein 7 vs. TrEMBL
Match: A0A074ZMB4 (Noggin OS=Opisthorchis viverrini OX=6198 GN=T265_04942 PE=4 SV=1)

HSP 1 Score: 159.458 bits (402), Expect = 3.517e-40
Identity = 91/282 (32.27%), Postives = 149/282 (52.84%), Query Frame = 1

Query:  517 SWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPD-----VLRGLMPVEQINARQELMKAVGNLNFTFV-DSVGAMLEIPENMQN----LFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQ-----------SKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK 1299
            SWPP+   +  ++ ++++G+ I +    + +P+    + +KL K+     L +QW+S++ P        R ++ +        L+KA G LNFT +  S G  + +P  M +    L + WL++ +SC++++VWEDLG +FWP WIRRG+C ++ +CSWP GM C+ SGSR L LLRWVC  D+N T+   LQ                    RRRR           +E Q             ++  R+ R LS  ++GY+C+WS  +Y ++D+C+C C+
Sbjct:  144 SWPPENSQEFARVDVRVMGERIDSVALLHLRPSSNAESIRKLRKILGS-DLQSQWMSVDPPPKDSERTSRSVVTMSMPPQDDRLLKAAGELNFTVLRPSPGTDMVVPVEMTHDQIELVKAWLVQRASCRLDYVWEDLGPLFWPRWIRRGICINTMACSWPPGMLCRPSGSRQLKLLRWVCKNDSNPTD-DDLQK-------------------RRRRHEYPFYYKRYKREGQLLRRRIPREERRSRRVRRLIRKLSLTANGYYCEWSRHEYVVSDQCACGCE 404

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Cavefish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 72.0182 bits (175), Expect = 3.719e-14
Identity = 30/75 (40.00%), Postives = 43/75 (57.33%), Query Frame = 1

Query:  820 ENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNG 1044
            + M+   + WL  Y+ C + + W+DLG  FWP +++ G C S +SCS P GM C  + S  L LLRW C+    G
Sbjct:  104 KKMRRRLQLWLWSYTFCPVVYAWQDLGSRFWPRYVKVGSCASKRSCSVPEGMVCSPAKSAHLTLLRWYCIPRKAG 178

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Cavefish
Match: ENSAMXT00000051007.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000650.1:142689:143405:-1 gene:ENSAMXG00000039724.1 transcript:ENSAMXT00000051007.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.8474 bits (146), Expect = 3.075e-10
Identity = 34/102 (33.33%), Postives = 50/102 (49.02%), Query Frame = 1

Query:  727 EQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLK 1032
            E  N   ELM+  G       D + A  +     +   R++  E + C +   W DLG  FWP ++R G C+  +SCS P+GM C  + S  + LLRW C +
Sbjct:   86 EPENNEHELMQRAGGSG----DHLHAGKKRKRRRRLWLREFERERALCPVVQTWSDLGARFWPRYVRMGSCSRERSCSVPAGMLCTPAASTHVTLLRWRCAR 183

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009391.1 (pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-1 gene:ENSPMAG00000008500.1 transcript:ENSPMAT00000009391.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 77.411 bits (189), Expect = 1.039e-16
Identity = 39/130 (30.00%), Postives = 60/130 (46.15%), Query Frame = 1

Query:  667 LDTQWLSINKPDVLRGLMPVEQINARQELMKAVGN--------LNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLC--TSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
             D  W+S+ +P        +  +  R   + A G         LNFT +   GA +   E       +WL++ + C +   W DLG +FWP W+RR  C  +    CSWP+GM+C  + S  + +L W C
Sbjct:   42 FDPFWMSVKRPSSSSTTGDIGALATRSSAVTAAGRKLHAAARALNFTVLTDSGAAVAATEATAAFMTRWLLQKAECGVASSWHDLGSVFWPRWVRRSHCEESGGGGCSWPAGMSCAPAQSTHIKILAWHC 171

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011420.1 (pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gene:ENSPMAG00000010393.1 transcript:ENSPMAT00000011420.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 73.1738 bits (178), Expect = 6.208e-15
Identity = 46/163 (28.22%), Postives = 72/163 (44.17%), Query Frame = 1

Query:  595 DSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLM-----PVEQ-------INARQELMKAVGNLNFTFV-------DSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            D    P  +  + + L +L    H D  ++S+  P  +RGL      P EQ           + +   + +++F             GA+         LF   L  Y+ C + + W+DLG  FWP ++R G C S +SCS P+GM+CK   S +  +LRW C
Sbjct:   51 DPELDPKTKDLDERVLRRLL-GSHFDPTFMSVAAPGEVRGLAKNASEPGEQHGRGAAAARRERAMPSEIRDMDFARAAWPDPRGSRAGALGRKARRKMQLF---LWAYTQCPVAYAWKDLGGRFWPRYVREGSCQSGRSCSIPAGMSCKAQRSTSKAILRWYC 209

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Sea Lamprey
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 70.8626 bits (172), Expect = 2.857e-14
Identity = 31/76 (40.79%), Postives = 47/76 (61.84%), Query Frame = 1

Query:  799 GAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            G  ++I +  +    +WL  Y+ C + + W+DLGE FWP +++ G C + +SCS+P GMACK   S +  LLRW C
Sbjct:  120 GQKIKIGKRARRKILQWLWSYTFCPVLYTWKDLGERFWPRFVKEGSCYNGRSCSFPEGMACKPFKSASKTLLRWHC 195

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Sea Lamprey
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 60.8474 bits (146), Expect = 6.916e-11
Identity = 27/76 (35.53%), Postives = 43/76 (56.58%), Query Frame = 1

Query:  799 GAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
            G  L++ +  +  F +WL  +++C + + W++L   FWP +I+ G C S++SCS P GM CK         LRW C
Sbjct:  131 GQKLKLGKRARRKFLQWLWAHTACPVVYSWKELNVRFWPRYIKEGSCYSARSCSVPEGMVCKPVKFSNKTFLRWHC 206

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Nematostella
Match: EDO36952 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH36])

HSP 1 Score: 58.9214 bits (141), Expect = 5.946e-11
Identity = 30/80 (37.50%), Postives = 44/80 (55.00%), Query Frame = 1

Query:  808 LEIPENMQNLFRK-------WLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
             ++P   +NL  K       WL E SSC +   W+D G++ WP +   G C+   +CS+P GM CK S ++ + LLRW C
Sbjct:   11 FQMPGEGRNLGPKASRKLQLWLWELSSCPVYQKWKDQGQLIWPRYRNIGRCSRKSTCSYPGGMKCKRSKTKRVALLRWFC 90

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Nematostella
Match: EDO36981 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH37])

HSP 1 Score: 53.9138 bits (128), Expect = 3.519e-9
Identity = 25/70 (35.71%), Postives = 39/70 (55.71%), Query Frame = 1

Query:  826 MQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKD 1035
            M+     WL++  +C + + W D+G  FWP +++R  C  SK CS      C+ S SR  ++LRW C+ D
Sbjct:    5 MERFMMGWLLQRENCPVVYSWRDMGPHFWPRFVKRATC-KSKQCSIDPSTQCEPSNSRYFNILRWHCMDD 73

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Medaka
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 73.1738 bits (178), Expect = 2.017e-14
Identity = 37/120 (30.83%), Postives = 62/120 (51.67%), Query Frame = 1

Query:  667 LDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVC 1026
             D  ++SI+ P  +       Q+  +  +   +  L+ T     G  +++ +  +  F +WL  Y+ C + + W+DLG  FWP +I+ G C S +SCS+P GM+CK + S     LRW C
Sbjct:   71 FDPNFMSISSPLQVNLSASDYQVKLQGPMPNEIKKLDLT-ETPYGKRVKVGKKARRKFLQWLWTYTHCPVVYTWKDLGVRFWPRYIKEGKCFSERSCSFPEGMSCKPAKSINKIFLRWYC 189

[Close]

BLAST of noggin-like protein 7 vs. Ensembl Medaka
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 70.0922 bits (170), Expect = 2.845e-13
Identity = 30/65 (46.15%), Postives = 40/65 (61.54%), Query Frame = 1

Query:  838 FRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLK 1032
             ++WL  YS C + + W DLG  FWP ++R G C S +SCS P GM CK + S  L  LRW C++
Sbjct:  137 LQQWLWAYSFCPVLYSWTDLGNRFWPRFVRVGSCLSKRSCSVPEGMVCKPASSTHLTTLRWRCVQ 201

[Close]

BLAST of noggin-like protein 7 vs. Planmine SMEST
Match: SMESG000016086.1 (SMESG000016086.1)

HSP 1 Score: 587.8 bits (1514), Expect = 0.000e+0
Identity = 303/303 (100.00%), Postives = 303/303 (100.00%), Query Frame = 1

Query:  391 FASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK 1299
            FASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQMLYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK
Sbjct:   11 FASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQMLYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQCK 313

[Close]

BLAST of noggin-like protein 7 vs. Planmine SMEST
Match: SMESG000008387.1 (SMESG000008387.1)

HSP 1 Score: 190.66 bits (483), Expect = 2.659e-56
Identity = 106/287 (36.93%), Postives = 166/287 (57.84%), Query Frame = 1

Query:  460 KAKVKLSDVMNEK------RRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTS--SKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQC 1296
            KA VK+S+V+  K      +  +   WP    DK  K+ ++++G NI     +N +P +  +N K+L++L  +   DT W SI+ P  L+      +     +L  A   LN TF D  G    +PE++  +FR WL++ ++C M+++WEDLG +FWP WIRRG+C +  ++SCSWP GM C+ SGSR LH+L W C +D N  E     N + + ++++  K+     +RRRR+P+    NN   +    K+  R+ ++ S AS+GY+C+W + KY INDKCSC C
Sbjct:   31 KANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKRLLHEKR-DTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREF----NRRKQRESRERNKRRWTKTRRRRRYPNEKTFNN---QENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSC 309

[Close]

BLAST of noggin-like protein 7 vs. Planmine SMEST
Match: SMESG000007405.1 (SMESG000007405.1)

HSP 1 Score: 129.413 bits (324), Expect = 5.569e-34
Identity = 80/237 (33.76%), Postives = 126/237 (53.16%), Query Frame = 1

Query:  598 SNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKP-DVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKATRITRL---LSRASDGYFCQWSMLKYYINDKCSCQC 1296
            +N  PNL     KKL+K+    HL   WL++ KP ++   L    +I++R  L   +   NF F +  G  + +  ++ +  + WL E SSCQM ++W +L   FWP WI++GLC S  SCSWP GM+CK   ++ L LL++ C +D    +    +    +L+  + K+Q   Y ++R  F    RSNN  + V  ++K  R   L   L    +G++C+W    YY+N+ CSC C
Sbjct:   34 TNFIPNLSPSIDKKLKKILDSDHLFDNWLALTKPAEIYIPLNGTNKIDSR--LRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVSLTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVF--QGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNELCSCSC 266

[Close]

BLAST of noggin-like protein 7 vs. Planmine SMEST
Match: SMESG000034704.1 (SMESG000034704.1)

HSP 1 Score: 129.028 bits (323), Expect = 1.275e-33
Identity = 80/237 (33.76%), Postives = 126/237 (53.16%), Query Frame = 1

Query:  598 SNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKP-DVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKATRITRL---LSRASDGYFCQWSMLKYYINDKCSCQC 1296
            +N  PNL     KKL+K+    HL   WL++ KP ++   L    +I++R  L   +   NF F +  G  + +  ++ +  + WL E SSCQM ++W +L   FWP WI++GLC S  SCSWP GM+CK   ++ L LL++ C +D    +    +    +L+  + K+Q   Y ++R  F    RSNN  + V  ++K  R   L   L    +G++C+W    YY+N+ CSC C
Sbjct:   55 TNFIPNLSPSIDKKLKKILDSDHLFGNWLALTKPAEIYIPLNGTNKIDSR--LRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVSLTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVF--QGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNELCSCSC 287

[Close]

BLAST of noggin-like protein 7 vs. Planmine SMEST
Match: SMESG000032255.1 (SMESG000032255.1)

HSP 1 Score: 127.102 bits (318), Expect = 4.605e-33
Identity = 69/246 (28.05%), Postives = 130/246 (52.85%), Query Frame = 1

Query:  565 LIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQ-ELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFXXXXXXXXXXXXXXXXXXRRRRFPDSTRSNNLSKEVQSKKKAT-RITRLLSRASDGYFCQWSMLKYYINDKCSCQC 1296
            LIG  +  +     KP     +   L+++    + +  W+S+N P ++     +E  N +Q +++ +  NL+FT  D  G ++   +N+    R+W+++ ++C+ +++W+ L E  WPSWI+ G+C+S++ CSWP GMACK S  +TL +L+W CL D  G   +K   F+  +   + ++++  +Q +R             K+ +  K+   R     S+ + GY CQW  + Y + + C+C C
Sbjct:   29 LIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFT--DEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLG---EKWNAFRELMHEDRKRRRLRRHQFKRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 269

The following BLAST results are available for this feature:

BLAST of noggin-like protein 7 vs. Ensembl Human
BLAST of noggin-like protein 7 vs. Ensembl Celegans
BLAST of noggin-like protein 7 vs. Ensembl Fly
BLAST of noggin-like protein 7 vs. Ensembl Zebrafish
BLAST of noggin-like protein 7 vs. Ensembl Xenopus
BLAST of noggin-like protein 7 vs. Ensembl Mouse
BLAST of noggin-like protein 7 vs. UniProt/SwissProt
BLAST of noggin-like protein 7 vs. TrEMBL
BLAST of noggin-like protein 7 vs. Ensembl Cavefish
BLAST of noggin-like protein 7 vs. Ensembl Sea Lamprey
BLAST of noggin-like protein 7 vs. Ensembl Yeast
BLAST of noggin-like protein 7 vs. Ensembl Nematostella
BLAST of noggin-like protein 7 vs. Ensembl Medaka
BLAST of noggin-like protein 7 vs. Planmine SMEST

BLAST of noggin-like protein 7 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
NOG	2.566e-11	35.23	noggin [Source:HGNC Symbol;Acc:HGNC:7866]	[more]

BLAST of noggin-like protein 7 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 7 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 7 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nog2	1.021e-16	31.14	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog1	1.004e-13	35.54	noggin 1 [Source:NCBI gene;Acc:30174]	[more]
nog3	1.229e-12	40.58	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	1.241e-12	40.58	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	1.241e-12	40.58	noggin 3 [Source:NCBI gene;Acc:30173]	[more]

BLAST of noggin-like protein 7 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nog4	2.854e-15	34.92	noggin 4 [Source:NCBI gene;Acc:733455]	[more]
acad10	5.791e-14	31.74	acyl-CoA dehydrogenase family member 10 [Source:Xe...	[more]
nog	2.442e-11	30.71	noggin [Source:NCBI gene;Acc:493191]	[more]

BLAST of noggin-like protein 7 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Nog	1.681e-11	35.23	noggin [Source:MGI Symbol;Acc:MGI:104327]	[more]

BLAST of noggin-like protein 7 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9W740\|NOGG2_DANRE	7.709e-16	31.14	Noggin-2 OS=Danio rerio OX=7955 GN=nog2 PE=2 SV=1	[more]
sp\|Q9W741\|NOGG1_DANRE	6.151e-13	35.54	Noggin-1 OS=Danio rerio OX=7955 GN=nog1 PE=2 SV=1	[more]
sp\|Q9YHT8\|NOGG_TAKRU	7.352e-13	44.93	Noggin OS=Takifugu rubripes OX=31033 GN=nog PE=3 S...	[more]
sp\|Q9YHV3\|NOGG3_DANRE	1.487e-11	40.58	Noggin-3 OS=Danio rerio OX=7955 GN=nog3 PE=1 SV=1	[more]
sp\|P97466\|NOGG_MOUSE	1.176e-10	35.23	Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1	[more]

BLAST of noggin-like protein 7 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C1JAC7	0.000e+0	100.00	Noggin-like protein 7 OS=Schmidtea mediterranea OX...	[more]
C1JAC8	8.848e-53	36.93	Noggin-like protein 8 OS=Schmidtea mediterranea OX...	[more]
A0A4S2M4R3	1.074e-40	31.07	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
G7YQS9	1.097e-40	31.79	Noggin-3 OS=Clonorchis sinensis OX=79923 GN=CLF_10...	[more]
A0A074ZMB4	3.517e-40	32.27	Noggin OS=Opisthorchis viverrini OX=6198 GN=T265_0...	[more]

BLAST of noggin-like protein 7 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog3	3.719e-14	40.00	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
ENSAMXT00000051007.1	3.075e-10	33.33	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of noggin-like protein 7 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000009391.1	1.039e-16	30.00	pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-...	[more]
ENSPMAT00000011420.1	6.208e-15	28.22	pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gen...	[more]
nog3	2.857e-14	40.79	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog2	6.916e-11	35.53	noggin 2 [Source:NCBI gene;Acc:30185]	[more]

BLAST of noggin-like protein 7 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 7 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36952	5.946e-11	37.50	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36981	3.519e-9	35.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of noggin-like protein 7 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog2	2.017e-14	30.83	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog1	2.845e-13	46.15	noggin 1 [Source:NCBI gene;Acc:30174]	[more]

BLAST of noggin-like protein 7 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000016086.1	0.000e+0	100.00	SMESG000016086.1	[more]
SMESG000008387.1	2.659e-56	36.93	SMESG000008387.1	[more]
SMESG000007405.1	5.569e-34	33.76	SMESG000007405.1	[more]
SMESG000034704.1	1.275e-33	33.76	SMESG000034704.1	[more]
SMESG000032255.1	4.605e-33	28.05	SMESG000032255.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30035881
GenBank	ACO06232.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30035881 ID=SMED30035881|Name=noggin-like protein 7|organism=Schmidtea mediterranea sexual|type=transcript|length=1496bp
GTGAAAAATAAAAGTAAAAATCACAGTGGAAATATCGAAAGAAAATACCC
TATCAACTAATAATTTATTTGAGGAAATGAACTGACCAATCAAAACGAAA
AGCACATAATTTAGCACATGAACCGAGAAATTTATTATATTCGATATAAA
ACGAAAATAAGATAATCGAAAAGATAATTAAATCAAATGATATTAGTTCT
ATCAAATATATTACTATTTCTCGAATTTTCATTGGTCAAAAATTAAATTA
TCAAATTTGGTAACTTTGAAAGTTTTACTGTAAATAAATCAGAATTATTA
TTACAAAACAAATATTTTATTCTGTTAATCTCAGTAAAAATAAATATCCA
AAAAATAATTATGGAAATAATTGTGATTTTGCTTTTAGTATTTGCTTCGT
TCTCGTCGTATTGTAAAGTAAGACGTGAAATTAACAACAATGAAGTGGAT
TTTTCAGATAAAGCCAAAGTCAAGCTAAGCGATGTCATGAATGAGAAACG
TCGGTCAAGAAGTGAATCCTGGCCACCTGATGAACAAGACAAGAATTTCA
AGTTGGGAATCAAATTAATCGGGGACAACATTTCAGCGAATTTTGATTCG
AATACCAAACCAAATCTCCAGCAAAGAAATCCGAAAAAATTGGAAAAGCT
TTTTTGGAAATATCATCTCGATACCCAATGGTTATCAATCAACAAACCAG
ACGTTTTGAGGGGTCTCATGCCAGTTGAGCAAATCAATGCTAGGCAAGAA
CTGATGAAAGCGGTTGGTAATTTGAATTTTACCTTTGTCGATTCAGTTGG
TGCAATGCTTGAGATTCCAGAAAACATGCAAAATCTTTTTAGAAAATGGT
TAATTGAATATTCATCCTGTCAGATGAATTTCGTTTGGGAAGATCTGGGA
GAAATGTTTTGGCCGAGTTGGATTAGACGAGGTTTATGTACGAGCTCTAA
ATCGTGTTCTTGGCCATCGGGTATGGCTTGTAAACATAGCGGTTCTCGGA
CACTGCATCTTTTGCGATGGGTCTGTTTAAAAGATACCAATGGAACTGAA
GCAAAAAAGTTGCAGAATTTTAAAATAAAATTAAAAACTCAGAAAATGAA
AAAGCAGATGCTGTATTATCAGAAACGACGACGAAGATTTCCCGACAGTA
CTCGATCAAACAACTTATCAAAGGAAGTACAAAGTAAGAAGAAGGCAACT
CGGATTACTCGACTCCTTTCAAGGGCATCCGATGGCTATTTCTGTCAGTG
GAGCATGCTAAAGTATTATATAAATGATAAGTGTTCATGTCAGTGTAAAT
AAAAACATTTCAACAGTTGTATCTATGCCAGCTGAATGTCAAAATGATTT
TATATACTCTCTTTCCATTCTGTCATTGAACTTTGTAAATAAACTTTGAT
GTTATCAGATCTGAAATTTTACCATGAAAAATAAGTATTCGTTTTTTAAT
AAAATTTTCTATGTACTTTTGTCGGTAAATTTATGATTATTGTGAG

protein sequence of SMED30035881-orf-1

>SMED30035881-orf-1 ID=SMED30035881-orf-1|Name=SMED30035881-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=314bp
MEIIVILLLVFASFSSYCKVRREINNNEVDFSDKAKVKLSDVMNEKRRSR
SESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWK
YHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAML
EIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCS
WPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQM
LYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSML
KYYINDKCSCQCK*

Aliases

The feature 'noggin-like protein 7' has the following synonyms


Synonym
nlg-7

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000101	muscle cell
PLANA:0000143	ventral region of the whole animal
PLANA:0000240	body wall musculature
PLANA:0003001	lateral region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR008717	Noggin
IPR029034	Cystine-knot_cytokine

Vocabulary: **biological process**
Term	Definition
GO:0030514	negative regulation of BMP signaling pathway
GO:0045596	negative regulation of cell differentiation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PFAM	PF05806	Noggin	coord: 78..312 e-value: 4.4E-24 score: 85.6
None	No IPR available	GENE3D	G3DSA:1.10.287.520		coord: 118..169 e-value: 2.5E-30 score: 108.0
None	No IPR available	PANTHER	PTHR10494:SF6	NOGGIN	coord: 49..312
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..18 score: 0.631
IPR029034	Cystine-knot cytokine	GENE3D	G3DSA:2.10.90.10		coord: 77..226 e-value: 2.5E-30 score: 108.0
IPR029034	Cystine-knot cytokine	SUPERFAMILY	SSF57501	Cystine-knot cytokines	coord: 77..312
IPR008717	Noggin	PANTHER	PTHR10494	BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN	coord: 49..312

Main menu

noggin-like protein 7

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Owlery

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