Betaine--homocysteine S-methyltransferase 1

Overview
NameBetaine--homocysteine S-methyltransferase 1
Smed IDSMED30035725
Length (bp)1042
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Betaine--homocysteine S-methyltransferase 1 (SMED30035725) t-SNE clustered cells

Violin plots show distribution of expression levels for Betaine--homocysteine S-methyltransferase 1 (SMED30035725) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Betaine--homocysteine S-methyltransferase 1 (SMED30035725) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Betaine--homocysteine S-methyltransferase 1 (SMED30035725) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30035725

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pigment cellSMED30035725h1SMcG0001346 SmedASXL_006472SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
gutSMED30035725h1SMcG0001346 dd_Smed_v4_873_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30035725h1SMcG0001346 dd_Smed_v4_873_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30035725h1SMcG0001346 dd_Smed_v4_873_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30035725h1SMcG0001346 dd_Smed_v4_873_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pigment cellSMED30035725h1SMcG0001346 dd_Smed_v6_873_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
glial cellSMED30035725h1SMcG0001346 dd_Smed_v6_873_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30035725h1SMcG0001346 SMED_01055_V2_1rGPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Human
Match: BHMT (betaine--homocysteine S-methyltransferase [Source:HGNC Symbol;Acc:HGNC:1047])

HSP 1 Score: 395.971 bits (1016), Expect = 1.221e-136
Identity = 186/307 (60.59%), Postives = 228/307 (74.27%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            I G  +N AAC +A++VA EG D LV GGVSQTPSYL+   +T  + +F +Q  VF ++ VDFL+ EYFEHVEEA WAVET      P+A T+CIGPEGD++ VP GECAVRLVKAGA+IIG+NCH DP I LK +K+M   +  A LKAH M QPL Y TPD + QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPWVRARA++EYWE LR  +GRP+  + + PD WGVT G  EL Q  E T + ++++L++
Sbjct:   94 ISGQEVNEAACDIARQVADEG-DALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFE 399          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Human
Match: BHMT2 (betaine--homocysteine S-methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:1048])

HSP 1 Score: 348.206 bits (892), Expect = 1.710e-118
Identity = 161/275 (58.55%), Postives = 202/275 (73.45%), Query Frame = 3
Query:   75 NINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPD 899
            ++N AAC LA++VA +G D LV GG+ QT  Y     +   + +FR+Q  VF  + VDFL+ EYFEHVEEA WAVE  KE + P+A T+CIGPEGDM+++  GECAVRLVKAGA+I+G+NC   P   LK M++M   +  AGLKAH M+QPLG+  PD   +GF+DLPE+PF LE R+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPW+RARA+REYWE L P +GRPF  + + PD
Sbjct:   89 DVNAAACDLAREVAGKG-DALVAGGICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSKPD 362          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Human
Match: BHMT2 (betaine--homocysteine S-methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:1048])

HSP 1 Score: 299.286 bits (765), Expect = 3.288e-100
Identity = 138/229 (60.26%), Postives = 170/229 (74.24%), Query Frame = 3
Query:  213 KQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPD 899
            + FT    E  D +  +YFEHVEEA WAVE  KE + P+A T+CIGPEGDM+++  GECAVRLVKAGA+I+G+NC   P   LK M++M   +  AGLKAH M+QPLG+  PD   +GF+DLPE+PF LE R+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPW+RARA+REYWE L P +GRPF  + + PD
Sbjct:   72 QTFTFSASE--DNMESKYFEHVEEAVWAVEVLKESDRPVAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSKPD 298          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Human
Match: BHMT (betaine--homocysteine S-methyltransferase [Source:HGNC Symbol;Acc:HGNC:1047])

HSP 1 Score: 263.848 bits (673), Expect = 5.142e-87
Identity = 122/202 (60.40%), Postives = 149/202 (73.76%), Query Frame = 3
Query:  378 TGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            T E AV   +AGA+IIG+NCH DP I LK +K+M   +  A LKAH M QPL Y TPD + QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPWVRARA++EYWE LR  +GRP+  + + PD WGVT G  EL Q  E T + ++++L++
Sbjct:   45 TPEAAVEHPEAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFE 246          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Zebrafish
Match: bhmt (betaine-homocysteine methyltransferase [Source:NCBI gene;Acc:322228])

HSP 1 Score: 409.068 bits (1050), Expect = 3.682e-142
Identity = 193/306 (63.07%), Postives = 229/306 (74.84%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQH 986
            G  IN AAC LA++VA+EG D LV GGVSQTPSYL+   +   +  F+KQ  VF ++ VD L+ EYFEHVEEAEWAV+  K    P+A TLCIGP+GDM+ V  GECAVRLVKAGA+I+G+NCH DP   +K + +M +AV  AGLKAH+M QPL Y TPD S QGFIDLPEFPFALEPRI TR++M +YAREAY AGIRYIGGCCGFE YHIRAVAEEL+ E G  PE S KH LWG GL+MHTKPWVRARA+R+YWEKL+P +GRP   + + PD WGVT GH  L Q  E T   ++  L+Q 
Sbjct:   91 GQQINEAACDLAREVANEG-DALVAGGVSQTPSYLSCKSEEEVKKTFKKQLDVFIKKNVDLLIAEYFEHVEEAEWAVQVLKATGKPVAATLCIGPDGDMHGVTPGECAVRLVKAGADIVGVNCHFDPLTCVKTVVMMKAAVEKAGLKAHYMTQPLAYHTPDCSCQGFIDLPEFPFALEPRILTRWEMQQYAREAYKAGIRYIGGCCGFEPYHIRAVAEELSAERGFLPEASQKHGLWGSGLEMHTKPWVRARARRDYWEKLKPASGRPLCPSMSTPDGWGVTRGHAALMQQKEATTAEQLRPLFQQ 395          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Zebrafish
Match: bhmt (betaine-homocysteine methyltransferase [Source:NCBI gene;Acc:322228])

HSP 1 Score: 408.297 bits (1048), Expect = 5.227e-142
Identity = 193/306 (63.07%), Postives = 229/306 (74.84%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQH 986
            G  IN AAC LA++VA+EG D LV GGVSQTPSYL+   +   +  F+KQ  VF ++ VD L+ EYFEHVEEAEWAV+  K    P+A TLCIGP+GDM+ V  GECAVRLVKAGA+I+G+NCH DP   +K + +M +AV  AGLKAH+M QPL Y TPD S QGFIDLPEFPFALEPRI TR++M +YAREAY AGIRYIGGCCGFE YHIRAVAEEL+ E G  PE S KH LWG GL+MHTKPWVRARA+R+YWEKL+P +GRP   + + PD WGVT GH  L Q  E T   ++  L+Q 
Sbjct:   83 GQQINEAACDLAREVANEG-DALVAGGVSQTPSYLSCKSEEEVKKTFKKQLDVFIKKNVDLLIAEYFEHVEEAEWAVQVLKATGKPVAATLCIGPDGDMHGVTPGECAVRLVKAGADIVGVNCHFDPLTCVKTVVMMKAAVEKAGLKAHYMTQPLAYHTPDCSCQGFIDLPEFPFALEPRILTRWEMQQYAREAYKAGIRYIGGCCGFEPYHIRAVAEELSAERGFLPEASQKHGLWGSGLEMHTKPWVRARARRDYWEKLKPASGRPLCPSMSTPDGWGVTRGHAALMQQKEATTAEQLRPLFQQ 387          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Xenopus
Match: kat6a (K(lysine) acetyltransferase 6A [Source:Xenbase;Acc:XB-GENE-6076141])

HSP 1 Score: 394.045 bits (1011), Expect = 4.489e-136
Identity = 186/308 (60.39%), Postives = 226/308 (73.38%), Query Frame = 3
Query:   57 KII*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            K I G  +N AAC +A++VA+EG D LV GGVSQTPSYL+   +   + IFRKQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGP+GD+N V  GECAVRL KAGA+++G+NCH DP   +  +K+M   +  A +KAH M QPL Y TPD   QGFIDLPEFPFALEPRI TR+D+HKYAREAY+ G+RYIGGCCGFE YH RA+AEELA E G  P GS+KH  WG GL+MHTKPWVRARA+R+YWEKL P +GRP   + + PD WGVT G  +L Q  E T + ++  L+
Sbjct:   84 KKISGQKVNEAACDIAREVANEG-DALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPQGDLNGVTPGECAVRLAKAGASVVGVNCHFDPMTCIATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYAREAYNLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPPGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPCCPSMSKPDAWGVTKGDADLMQQKEATTEQQLIDLF 390          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Xenopus
Match: kat6a (K(lysine) acetyltransferase 6A [Source:Xenbase;Acc:XB-GENE-6076141])

HSP 1 Score: 394.045 bits (1011), Expect = 5.310e-136
Identity = 186/308 (60.39%), Postives = 226/308 (73.38%), Query Frame = 3
Query:   57 KII*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            K I G  +N AAC +A++VA+EG D LV GGVSQTPSYL+   +   + IFRKQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGP+GD+N V  GECAVRL KAGA+++G+NCH DP   +  +K+M   +  A +KAH M QPL Y TPD   QGFIDLPEFPFALEPRI TR+D+HKYAREAY+ G+RYIGGCCGFE YH RA+AEELA E G  P GS+KH  WG GL+MHTKPWVRARA+R+YWEKL P +GRP   + + PD WGVT G  +L Q  E T + ++  L+
Sbjct:   89 KKISGQKVNEAACDIAREVANEG-DALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPQGDLNGVTPGECAVRLAKAGASVVGVNCHFDPMTCIATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYAREAYNLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPPGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPCCPSMSKPDAWGVTKGDADLMQQKEATTEQQLIDLF 395          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Xenopus
Match: kat6a (K(lysine) acetyltransferase 6A [Source:Xenbase;Acc:XB-GENE-6076141])

HSP 1 Score: 393.275 bits (1009), Expect = 8.777e-136
Identity = 186/308 (60.39%), Postives = 226/308 (73.38%), Query Frame = 3
Query:   57 KII*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            K I G  +N AAC +A++VA+EG D LV GGVSQTPSYL+   +   + IFRKQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGP+GD+N V  GECAVRL KAGA+++G+NCH DP   +  +K+M   +  A +KAH M QPL Y TPD   QGFIDLPEFPFALEPRI TR+D+HKYAREAY+ G+RYIGGCCGFE YH RA+AEELA E G  P GS+KH  WG GL+MHTKPWVRARA+R+YWEKL P +GRP   + + PD WGVT G  +L Q  E T + ++  L+
Sbjct:   90 KKISGQKVNEAACDIAREVANEG-DALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPQGDLNGVTPGECAVRLAKAGASVVGVNCHFDPMTCIATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYAREAYNLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPPGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPCCPSMSKPDAWGVTKGDADLMQQKEATTEQQLIDLF 396          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Xenopus
Match: kat6a (K(lysine) acetyltransferase 6A [Source:Xenbase;Acc:XB-GENE-6076141])

HSP 1 Score: 392.889 bits (1008), Expect = 1.517e-135
Identity = 186/308 (60.39%), Postives = 226/308 (73.38%), Query Frame = 3
Query:   57 KII*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            K I G  +N AAC +A++VA+EG D LV GGVSQTPSYL+   +   + IFRKQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGP+GD+N V  GECAVRL KAGA+++G+NCH DP   +  +K+M   +  A +KAH M QPL Y TPD   QGFIDLPEFPFALEPRI TR+D+HKYAREAY+ G+RYIGGCCGFE YH RA+AEELA E G  P GS+KH  WG GL+MHTKPWVRARA+R+YWEKL P +GRP   + + PD WGVT G  +L Q  E T + ++  L+
Sbjct:   92 KKISGQKVNEAACDIAREVANEG-DALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPQGDLNGVTPGECAVRLAKAGASVVGVNCHFDPMTCIATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYAREAYNLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPPGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPCCPSMSKPDAWGVTKGDADLMQQKEATTEQQLIDLF 398          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Xenopus
Match: kat6a (K(lysine) acetyltransferase 6A [Source:Xenbase;Acc:XB-GENE-6076141])

HSP 1 Score: 392.504 bits (1007), Expect = 7.240e-135
Identity = 186/308 (60.39%), Postives = 226/308 (73.38%), Query Frame = 3
Query:   57 KII*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            K I G  +N AAC +A++VA+EG D LV GGVSQTPSYL+   +   + IFRKQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGP+GD+N V  GECAVRL KAGA+++G+NCH DP   +  +K+M   +  A +KAH M QPL Y TPD   QGFIDLPEFPFALEPRI TR+D+HKYAREAY+ G+RYIGGCCGFE YH RA+AEELA E G  P GS+KH  WG GL+MHTKPWVRARA+R+YWEKL P +GRP   + + PD WGVT G  +L Q  E T + ++  L+
Sbjct:  124 KKISGQKVNEAACDIAREVANEG-DALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPQGDLNGVTPGECAVRLAKAGASVVGVNCHFDPMTCIATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYAREAYNLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPPGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPCCPSMSKPDAWGVTKGDADLMQQKEATTEQQLIDLF 430          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Mouse
Match: Gm5096 (predicted gene 5096 [Source:MGI Symbol;Acc:MGI:3643681])

HSP 1 Score: 392.889 bits (1008), Expect = 1.399e-135
Identity = 181/307 (58.96%), Postives = 226/307 (73.62%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            I G  +N AAC +A++VA EG D LV GGVSQTPSYL+   +   + IFR+Q  VF ++ VDFL+ EYFEHVEEA WAVE  K    P+A T+CIGPEGD++ VP GECAVRLVKAGA+I+G+NCH DP + L+ +K+M   +  A LKA+ M QPL Y TPD   QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPW+RARA++EYW+ LR  +GRP+  + + PD WGVT G  EL Q  E T + ++ +L++
Sbjct:   94 ISGQKVNEAACDIARQVADEG-DALVAGGVSQTPSYLSCKSEVEVKKIFRQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIVGVNCHFDPSVSLQTVKLMKEGLEAARLKAYLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSRPDAWGVTKGAAELMQQKEATTEQQLRELFE 399          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Mouse
Match: Bhmt (betaine-homocysteine methyltransferase [Source:MGI Symbol;Acc:MGI:1339972])

HSP 1 Score: 392.889 bits (1008), Expect = 1.399e-135
Identity = 181/307 (58.96%), Postives = 226/307 (73.62%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            I G  +N AAC +A++VA EG D LV GGVSQTPSYL+   +   + IFR+Q  VF ++ VDFL+ EYFEHVEEA WAVE  K    P+A T+CIGPEGD++ VP GECAVRLVKAGA+I+G+NCH DP + L+ +K+M   +  A LKA+ M QPL Y TPD   QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPW+RARA++EYW+ LR  +GRP+  + + PD WGVT G  EL Q  E T + ++ +L++
Sbjct:   94 ISGQKVNEAACDIARQVADEG-DALVAGGVSQTPSYLSCKSEVEVKKIFRQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIVGVNCHFDPSVSLQTVKLMKEGLEAARLKAYLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSRPDAWGVTKGAAELMQQKEATTEQQLRELFE 399          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Mouse
Match: Bhmt2 (betaine-homocysteine methyltransferase 2 [Source:MGI Symbol;Acc:MGI:1891379])

HSP 1 Score: 331.643 bits (849), Expect = 3.149e-112
Identity = 159/274 (58.03%), Postives = 198/274 (72.26%), Query Frame = 3
Query:   78 INRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPD 899
            +N AAC LA++VA  G  ++  G + QT  Y     +T  +NIFR Q  VF  + VDFL+ EYFEHVEEA WAVE  +E   P+A T+CIGPEGDM++V  GECAV+L +AGA+IIG+NC   P+  L+ MK+M   + DA L+AH M+Q LG+ TPD    GF+DLPE+PF LEPR+ TR+D+ KYAREAY+ GIRYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPW+RARA+REYWE L P +GRPF  + + PD
Sbjct:   90 VNAAACDLAQEVAGGGGALVAGG-ICQTSLYKYHKDETRIKNIFRLQLEVFARKNVDFLIAEYFEHVEEAVWAVEVLREVGAPVAVTMCIGPEGDMHDVTPGECAVKLARAGADIIGVNCRFGPWTSLQTMKLMKEGLRDASLQAHLMVQCLGFHTPDCGKGGFVDLPEYPFGLEPRVATRWDIQKYAREAYNLGIRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLNMHTKPWIRARARREYWENLLPASGRPFCPSLSKPD 362          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. UniProt/SwissProt
Match: sp|Q32LQ4|BHMT1_DANRE (Betaine--homocysteine S-methyltransferase 1 OS=Danio rerio OX=7955 GN=bhmt PE=2 SV=1)

HSP 1 Score: 408.683 bits (1049), Expect = 4.208e-141
Identity = 193/306 (63.07%), Postives = 229/306 (74.84%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQH 986
            G  IN AAC LA++VA+EG D LV GGVSQTPSYL+   +   +  F+KQ  VF ++ VD L+ EYFEHVEEAEWAV+  K    P+A TLCIGP+GDM+ V  GECAVRLVKAGA+I+G+NCH DP   +K + +M +AV  AGLKAH+M QPL Y TPD S QGFIDLPEFPFALEPRI TR++M +YAREAY AGIRYIGGCCGFE YHIRAVAEEL+ E G  PE S KH LWG GL+MHTKPWVRARA+R+YWEKL+P +GRP   + + PD WGVT GH  L Q  E T   ++  L+Q 
Sbjct:   91 GQQINEAACDLAREVANEG-DALVAGGVSQTPSYLSCKSEEEVKKTFKKQLDVFIKKNVDLLIAEYFEHVEEAEWAVQVLKATGKPVAATLCIGPDGDMHGVIPGECAVRLVKAGADIVGVNCHFDPLTCVKTVAMMKAAVEKAGLKAHYMTQPLAYHTPDCSCQGFIDLPEFPFALEPRILTRWEMQQYAREAYKAGIRYIGGCCGFEPYHIRAVAEELSAERGFLPEASQKHGLWGSGLEMHTKPWVRARARRDYWEKLKPASGRPLCPSMSTPDGWGVTRGHAALMQQKEATTAEQLRPLFQQ 395          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. UniProt/SwissProt
Match: sp|Q5XGM3|BHMT1_XENLA (Betaine--homocysteine S-methyltransferase 1 OS=Xenopus laevis OX=8355 GN=bhmt PE=2 SV=1)

HSP 1 Score: 395.971 bits (1016), Expect = 3.949e-136
Identity = 185/305 (60.66%), Postives = 225/305 (73.77%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKL 977
            I G  +N  AC +A++VA+EG D LV GGVSQTPSYL+   +   + IFRKQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGPEGD+N V  GECAVRL KAGA+++G+NCH DP   +  +K+M   +  A +KAH M QPL Y TPD   QGFIDLPEFPFALEPRI TR+D+HKYAR AYD G+RYIGGCCGFE YH RA+AEELA E G  P+GS+KH  WG GL+MHTKPWVRARA+R+YWEKL P +GRP+  + + PD WGVT G  +L Q  E T + +++ L
Sbjct:   91 ISGQKVNEVACDIAREVANEG-DALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPEGDLNGVSPGECAVRLAKAGASVVGVNCHFDPMTCVATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYARAAYDLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPKGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPYCPSMSKPDEWGVTKGDADLMQQKEATTEQQLKDL 394          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. UniProt/SwissProt
Match: sp|Q93088|BHMT1_HUMAN (Betaine--homocysteine S-methyltransferase 1 OS=Homo sapiens OX=9606 GN=BHMT PE=1 SV=2)

HSP 1 Score: 395.971 bits (1016), Expect = 5.863e-136
Identity = 186/307 (60.59%), Postives = 228/307 (74.27%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            I G  +N AAC +A++VA EG D LV GGVSQTPSYL+   +T  + +F +Q  VF ++ VDFL+ EYFEHVEEA WAVET      P+A T+CIGPEGD++ VP GECAVRLVKAGA+IIG+NCH DP I LK +K+M   +  A LKAH M QPL Y TPD + QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPWVRARA++EYWE LR  +GRP+  + + PD WGVT G  EL Q  E T + ++++L++
Sbjct:   94 ISGQEVNEAACDIARQVADEG-DALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFE 399          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. UniProt/SwissProt
Match: sp|Q5RFG2|BHMT1_PONAB (Betaine--homocysteine S-methyltransferase 1 OS=Pongo abelii OX=9601 GN=BHMT PE=2 SV=1)

HSP 1 Score: 394.815 bits (1013), Expect = 1.314e-135
Identity = 186/307 (60.59%), Postives = 227/307 (73.94%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            I G  +N AAC +A++VA EG D LV GGVSQTPSYL+   +T  + +F +Q  VF ++ VDFL+ EYFEHVEEA WAVET      P+A T+CIGPEGD++ VP GECAVRLVKAGA+IIG+NCH DP I LK +K+M   +  A LKAH M QPL Y TPD + QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ GIRYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG  L MHTKPWVRARA++EYWE LR  +GRP+  + + PD WGVT G  EL Q  E T + ++++L++
Sbjct:   94 ISGQKVNEAACDIARQVADEG-DALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNMGIRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSALDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFE 399          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. UniProt/SwissProt
Match: sp|Q5I597|BHMT1_BOVIN (Betaine--homocysteine S-methyltransferase 1 OS=Bos taurus OX=9913 GN=BHMT PE=2 SV=1)

HSP 1 Score: 394.43 bits (1012), Expect = 2.396e-135
Identity = 182/307 (59.28%), Postives = 228/307 (74.27%), Query Frame = 3
Query:   63 I*GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            I G  +N AAC +A++VA EG D LV GGVSQTPSYL+   +T  + +F++Q  VF ++ VDFL+ EYFEHVEEA WAVE  K    P+A T+CIGPEGD+++V  GECAVRLVKAGA+I+G+NCH DP I L+ +K+M   +  AGLKAH M QPL Y TPD   QGFIDLPEFPF LEPR+ TR+D+ KYAREAY+ G+RYIGGCCGFE YHIRA+AEELA E G  P  S+KH  WG GL MHTKPW+RARA++EYWE L+  +GRP+  + + PD WGVT G  EL Q  E T + ++ +L++
Sbjct:   94 ISGQKVNEAACDIARQVADEG-DALVAGGVSQTPSYLSCKSETEVKKVFQQQLEVFVKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHSVTPGECAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGLKAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASGRPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFE 399          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. TrEMBL
Match: A0A1E1XH73 (Putative cysteine s-methyltransferase (Fragment) OS=Amblyomma aureolatum OX=187763 PE=2 SV=1)

HSP 1 Score: 440.269 bits (1131), Expect = 3.480e-151
Identity = 204/306 (66.67%), Postives = 244/306 (79.74%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEH-GRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            GA+IN AACKLA++VASE K  LV GG+SQTPSYL+G  K   Q+IFRKQ +VF + ++DFL+CEYFEHVEE E A+E  KE  LPI  TLCIGPEGDM+ V  GECAVR+VKAGAN++GINCH DPF+VL+ +K+MI AV  AGLKAHF+ QPL Y TPD   QGFIDLPEFPFALEPR+C+R+D+ +YAREAY+ G+RYIGGCCGFE YH+RA+AEEL+ E  G  P+ S KHD WG GL+MHTKPWVRARA R YWE L+P TGRPF++A++ PD WGVTAG+ ELKQ    T   EIEKL +
Sbjct:   86 GADINEAACKLAQEVASE-KKALVAGGISQTPSYLSGCSKAEVQDIFRKQVSVFVKNKLDFLICEYFEHVEEMEMAIEVCKETGLPIVATLCIGPEGDMHGVSAGECAVRMVKAGANVVGINCHFDPFVVLEGVKLMIEAVRAAGLKAHFIPQPLAYHTPDAGKQGFIDLPEFPFALEPRVCSRWDIQRYAREAYELGVRYIGGCCGFEPYHVRAIAEELSAERGGALPDASQKHDTWGEGLRMHTKPWVRARASRAYWENLKPSTGRPFSSAFSQPDNWGVTAGNAELKQQTSATTREEIEKLQK 390          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. TrEMBL
Match: A0A2R5L490 (Putative cysteine s-methyltransferase OS=Ornithodoros turicata OX=34597 PE=4 SV=1)

HSP 1 Score: 437.958 bits (1125), Expect = 3.359e-150
Identity = 205/306 (66.99%), Postives = 247/306 (80.72%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKE-HGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            G +IN AACK+AK+VASEG   LV GGVSQTP++L+G  K   Q  FRKQ  VF E ++DFL+CEYFEHVEE E A++  KE  LPI  T+CIGPEGD++ V  GECAVR+VKAGA+++G+NCH DPF+VL+ +K+MI AV+ +GLKAHF+ QPL Y TPD   QGFIDLPEFPFALEPR+CTR+DM +YAREAY+ G+RYIGGCCGFE YHIRA+AEELA++ H   PE S+KHD WG GLKMHTKPWVRARA REYWE L+P TGRPF++AY+ PD WGVTAG +ELKQ AE T   E+EKL+Q
Sbjct:   89 GEDINVAACKIAKEVASEGT-ALVAGGVSQTPAFLSGRSKAQVQEEFRKQVRVFIENQLDFLVCEYFEHVEEIEIAIKVCKETPLPIVATMCIGPEGDLHGVSAGECAVRMVKAGAHVVGVNCHFDPFVVLETVKLMIDAVNASGLKAHFITQPLAYHTPDAGKQGFIDLPEFPFALEPRVCTRWDMQRYAREAYEMGVRYIGGCCGFEPYHIRALAEELAEDRHSALPEASEKHDPWGAGLKMHTKPWVRARAFREYWETLKPATGRPFSSAYSQPDNWGVTAGAEELKQKAEDTTKEELEKLHQ 393          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. TrEMBL
Match: T1JFQ0 (Hcy-binding domain-containing protein OS=Strigamia maritima OX=126957 PE=4 SV=1)

HSP 1 Score: 434.876 bits (1117), Expect = 6.329e-149
Identity = 195/307 (63.52%), Postives = 241/307 (78.50%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQHM 989
            G+ IN AAC++ K+VA+EG D L LGG+SQTPSYL+G+GK   Q  F+KQ  VF + ++DF+LCEYFEHVEE EWA+E  K+F  P+A T+CIGP GD++ V  G+CAVR+ +AGA+I+G+NCH DPF+ L  +K+M +A+ D GL  H M QPLG  TPD   QGFIDLPEFPFALEPRICTR+DM KYAREA++AG+RYIGGCCGFE YHIRAVAEELA E GR P  SDKHD+W  GLKMHTKPWVRARA R YWE+L+P +GRP++A  A PD WGVTAGH+ LKQHA++T + E  K  + +
Sbjct:   90 GSAINEAACQIVKRVAAEG-DALTLGGLSQTPSYLSGLGKEAVQAEFKKQVQVFVKHDLDFVLCEYFEHVEEIEWAIEACKQFGKPVAATMCIGPHGDLHGVSAGQCAVRMARAGADIVGLNCHFDPFVTLDTIKVMKAALQDEGLDRHLMTQPLGLHTPDAGRQGFIDLPEFPFALEPRICTRWDMQKYAREAFEAGVRYIGGCCGFEPYHIRAVAEELAPERGRLPAASDKHDMWAQGLKMHTKPWVRARASRTYWEQLKPASGRPYSACMARPDGWGVTAGHETLKQHAKVTSEDEQNKALEFL 395          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. TrEMBL
Match: A0A4Y2L3D9 (Betaine--homocysteine S-methyltransferase 1 (Fragment) OS=Araneus ventricosus OX=182803 GN=BHMT PE=4 SV=1)

HSP 1 Score: 430.639 bits (1106), Expect = 1.140e-147
Identity = 195/309 (63.11%), Postives = 244/309 (78.96%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQHMMK 995
            G++IN AAC++A++VASEG D LV GG+SQTPSYL+G  K + Q  FRKQ  VF   +VDFL+CEYFEH+EE EWA+E  +E +LPIA T+CIG EGD++ V  GECAVR+ KAGA+++G+NCH DPF +L A+  M  A+  AGLK + M QPL ++ PDN  QGFIDLPEFPFALEPR+CTR+DM +YAR AY+ G+RYIGGCCGFE+YHIRAV+EELAKE G+ P  S KHD WG GL+MHTKPWVRARA+R YWE L+P TGRP +AA++ PD WGVTAG +ELKQ AE T + E++K++ H  K
Sbjct:   67 GSDINEAACRIAREVASEG-DALVAGGISQTPSYLSGKSKRSVQEEFRKQVQVFVSNKVDFLICEYFEHIEEMEWAIEVCRETSLPIASTMCIGTEGDLHGVGAGECAVRMAKAGAHVVGLNCHFDPFGMLDAIAAMKKALDAAGLKPYLMTQPLAFLCPDNGKQGFIDLPEFPFALEPRVCTRWDMQRYARRAYELGVRYIGGCCGFESYHIRAVSEELAKERGKQPLSSQKHDPWGEGLRMHTKPWVRARARRSYWEGLQPATGRPHSAAFSRPDNWGVTAGSEELKQQAESTTNEELQKMFAHNAK 374          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. TrEMBL
Match: A0A1Z5LG74 (Hcy-binding domain-containing protein (Fragment) OS=Ornithodoros moubata OX=6938 PE=4 SV=1)

HSP 1 Score: 431.409 bits (1108), Expect = 1.335e-147
Identity = 203/306 (66.34%), Postives = 244/306 (79.74%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEH-GRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            G +IN AACK+AK+VA+EG D LV GG+SQTPS+L+G  K   +  FRKQ  VF + ++DFL+CEYFEHVEE E A++  +E +LP+  ++CIGPEGD++ V  GECAVR+VKAGA+++G+NCH DPFIVLK +K+MI AV   GLKAHF+ QPL Y TPD   QGFIDLPEFPFALEPR+C+R+DM KYAREAY+ GIRYIGGCCGFE YHIRAVAEEL +E  G+ P  S+KHD WG GLKMHTKPWVRARA REYWE L+P TGRPF AAY+ PD WGVTAG DELKQ AE T   E++KL +
Sbjct:   88 GEDINAAACKIAKEVAAEG-DALVGGGLSQTPSFLSGKTKEEVKEEFRKQVRVFVDNKLDFLICEYFEHVEEIELAIQVCRETSLPVVSSMCIGPEGDLHGVSAGECAVRMVKAGAHVVGVNCHFDPFIVLKTLKLMIDAVKAEGLKAHFITQPLAYHTPDAGKQGFIDLPEFPFALEPRVCSRWDMQKYAREAYELGIRYIGGCCGFEPYHIRAVAEELVQERGGKLPLASEKHDPWGEGLKMHTKPWVRARAFREYWENLKPATGRPFCAAYSRPDNWGVTAGADELKQKAEDTTKEELQKLQE 392          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Cavefish
Match: bhmt (betaine--homocysteine S-methyltransferase 1 [Source:NCBI gene;Acc:103034807])

HSP 1 Score: 407.527 bits (1046), Expect = 1.484e-141
Identity = 186/305 (60.98%), Postives = 236/305 (77.38%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            G  +N AAC LA++VA+EG D LV GGVSQTPSYL+   +T+ + IF+KQ  VF +++VDFL+ EYFEHVEEAEWAV+  K    P+A ++CIGP+GDM+ V  G+CAVRLVKAGA+I+G+NCH DP   +K + +M +AV  AGLKAH+M+QPL Y TPD + QGFIDLPEFPFALEPR+ TR+DM +YAREA++AGIRYIGGCCG+E YHIRAVAEELA+E G  PE S KH +WG GL+MHTKPWVRARA+R+YWEK++P +GRP   + + PD WGVT G   L Q  E T   ++  L++
Sbjct:   90 GQQVNEAACDLARQVANEG-DALVAGGVSQTPSYLSCKSETDVKAIFKKQMDVFIKKDVDFLIAEYFEHVEEAEWAVQVLKSTGKPVAASMCIGPKGDMHGVTPGDCAVRLVKAGADIVGVNCHFDPMTCVKTVAMMKAAVEKAGLKAHYMVQPLAYHTPDCNCQGFIDLPEFPFALEPRVLTRWDMQQYAREAFNAGIRYIGGCCGYEPYHIRAVAEELAQERGFLPEASKKHGMWGSGLEMHTKPWVRARARRDYWEKMKPASGRPLCPSMSTPDGWGVTKGDAALMQQKEATTKDQLRPLFE 393          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Cavefish
Match: bhmt (betaine--homocysteine S-methyltransferase 1 [Source:NCBI gene;Acc:103034807])

HSP 1 Score: 409.068 bits (1050), Expect = 3.867e-141
Identity = 186/305 (60.98%), Postives = 236/305 (77.38%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            G  +N AAC LA++VA+EG D LV GGVSQTPSYL+   +T+ + IF+KQ  VF +++VDFL+ EYFEHVEEAEWAV+  K    P+A ++CIGP+GDM+ V  G+CAVRLVKAGA+I+G+NCH DP   +K + +M +AV  AGLKAH+M+QPL Y TPD + QGFIDLPEFPFALEPR+ TR+DM +YAREA++AGIRYIGGCCG+E YHIRAVAEELA+E G  PE S KH +WG GL+MHTKPWVRARA+R+YWEK++P +GRP   + + PD WGVT G   L Q  E T   ++  L++
Sbjct:  170 GQQVNEAACDLARQVANEG-DALVAGGVSQTPSYLSCKSETDVKAIFKKQMDVFIKKDVDFLIAEYFEHVEEAEWAVQVLKSTGKPVAASMCIGPKGDMHGVTPGDCAVRLVKAGADIVGVNCHFDPMTCVKTVAMMKAAVEKAGLKAHYMVQPLAYHTPDCNCQGFIDLPEFPFALEPRVLTRWDMQQYAREAFNAGIRYIGGCCGYEPYHIRAVAEELAQERGFLPEASKKHGMWGSGLEMHTKPWVRARARRDYWEKMKPASGRPLCPSMSTPDGWGVTKGDAALMQQKEATTKDQLRPLFE 473          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004959.1 (pep scaffold:Pmarinus_7.0:GL478860:9466:10943:1 gene:ENSPMAG00000004502.1 transcript:ENSPMAT00000004959.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 190.66 bits (483), Expect = 8.915e-61
Identity = 86/135 (63.70%), Postives = 106/135 (78.52%), Query Frame = 3
Query:  579 PEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRA-RAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            P  P ALEPRICTR++MH+YAREAY  G+RYIGGCCGFEAYH+RA+AEELA E GR P  S+KHD WG GL MHTKPWVRA RA+++YWEKL P TGRPF+ A + PD WG+T GH +L Q  + T + +++ L+
Sbjct:    1 PHAPPALEPRICTRWEMHRYAREAYALGVRYIGGCCGFEAYHVRAMAEELAVERGRLPAASEKHDSWGAGLGMHTKPWVRASRARKDYWEKLEPSTGRPFSCACSHPDSWGITKGHADLVQQTDATTENQLKALF 135          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Nematostella
Match: EDO47743 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLS1])

HSP 1 Score: 421.394 bits (1082), Expect = 1.361e-147
Identity = 196/304 (64.47%), Postives = 240/304 (78.95%), Query Frame = 3
Query:   72 ANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQ 983
            A IN AAC LA++VA EG D LV GGV QTP+YL+G GK   Q  F+KQ  VF +++VDF++ EY+EHVEEA WAVE  K+   PIA +LCIGPEGDM+ V  G+CAVRL +AGA+ IG+NCH  P   L+ M++M + +  AG K H MIQPLGY TPD   QGFIDLPEFPF LEPRICTR+DMHKYAREAYD GIR+IGGCCGFE YHIRA++EELAKE G+FP+GS+KH LWG GL+ HTKPWVR+RA+R+YWEKL P +GRPF+A+ + PD WG+TAGHD LKQHAE T D E++++ +
Sbjct:   91 AAINEAACDLAREVADEG-DALVAGGVCQTPTYLSGKGKEACQAEFQKQVDVFIKKDVDFIIAEYYEHVEEAVWAVELLKKTGKPIAASLCIGPEGDMHGVSAGDCAVRLAEAGADCIGVNCHYGPIKSLETMRLMKAGLDAAGYKKHLMIQPLGYHTPDCGKQGFIDLPEFPFGLEPRICTRWDMHKYAREAYDMGIRFIGGCCGFEPYHIRALSEELAKERGKFPKGSEKHGLWGDGLRQHTKPWVRSRARRDYWEKLNPSSGRPFSASCSKPDNWGITAGHDYLKQHAEDTSDKELKEIME 393          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Nematostella
Match: EDO48830 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIN7])

HSP 1 Score: 296.975 bits (759), Expect = 4.986e-99
Identity = 147/282 (52.13%), Postives = 184/282 (65.25%), Query Frame = 3
Query:   78 INRAACKLAKKVASEGKDVLVLGGVSQTPS-YLTGIG-KTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVP-DRWGVT 914
            I+ A   LAK V+ EG+  L  G + +T S +  G+  K   Q  FR Q  +F +  +D ++ EY  HV+EAEW VE  KE  +P A +L I  EGD + V  GECA+RLV+AGA+IIG+NC  DP   L  + +M  A+   GLK H+M+QP+GY  PD    GF  +PE P ALEPR+ TR + HK+AR+AY+ G+RYIGGCCGFE YHIRAVAEELAKE GRFP GSDK  LWG  L  H +P +  RA REYWE L P TGRPF+AAYA   D W  +
Sbjct:   81 ISHAGSLLAKGVSGEGEFALASGSLCETGSLFRKGLASKEEIQQRFRDQVQIFVDTGMDLIIAEYISHVQEAEWMVEVIKESGMPTAVSLAISREGDHHGVLPGECALRLVRAGADIIGVNCRFDPERSLDTIALMQEAIQREGLKTHWMVQPVGYWVPDAGPSGFTSIPENPLALEPRLMTRIEAHKFARKAYNMGVRYIGGCCGFEPYHIRAVAEELAKERGRFPPGSDKSCLWGKALVHHAEPQIARRANREYWENLEPATGRPFSAAYATTEDTWKTS 362          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Nematostella
Match: EDO48828 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIN5])

HSP 1 Score: 288.115 bits (736), Expect = 1.517e-95
Identity = 145/287 (50.52%), Postives = 185/287 (64.46%), Query Frame = 3
Query:   75 NINRAACKLAKKVASEGKDVLVLGGVSQTPS-YLTGIG-KTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAV-PDRWGVTAGHD 926
             I+ A   LAK+V+ EG+  L  G + +T S ++ G+  K   +  FR Q  +F +  +D L+ EY  HV+EAEW VE  KE   P+A T+ I  EGD + V  GECAVRLV+AGA+IIG+NC  DP   L  + +M  A+   GLK H+M+QPLGY  PD    GF  +PE   ALEPR+ TR + HK+AR+AY+ G+RYIGGCCGFE YHIRA+A+EL+KE GR P GSDK  LWG  L  H +  V  RA REYWEKL P TGRPF+ A+AV  D W     H+
Sbjct:   88 EISHAGSILAKEVSDEGEFALSSGSLCETGSLFIKGLASKEEIKQRFRDQVKIFVDTGMDLLIAEYISHVQEAEWMVEVMKESGKPVAVTMAISREGDRHGVLPGECAVRLVRAGADIIGVNCRFDPERSLDTIALMQEAIQREGLKTHWMVQPLGYWCPDAGPSGFTSIPECTLALEPRVLTRIEAHKFARKAYNMGVRYIGGCCGFEPYHIRALAKELSKERGRLPPGSDKSCLWGEALVHHAEAQVARRATREYWEKLVPATGRPFSPAFAVHEDTWKTEKKHE 374          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Nematostella
Match: EDO48829 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIN6])

HSP 1 Score: 268.855 bits (686), Expect = 2.819e-87
Identity = 134/264 (50.76%), Postives = 172/264 (65.15%), Query Frame = 3
Query:   78 INRAACKLAKKVASEGKDVLVLGGVSQTPS-YLTGIG-KTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCT 863
            I+RA   LAK+V+ +G+  L  G + +T S ++ G+  K   +  FR Q  +F +  +D L+ EY  HV+EAEW VE  KE   P+A T+ I  EGD + V  GECAVRLV+AGA+IIG+N   DP   L  + +M  A+   GLK H+M+QPLGY  PD    G   +PE   AL+PR+ TR + HK+AR+AY+ G+RYIGGCCGFE YHIRA+AEELA E GRFP GSDK  LWG  L  HT+P +  RA REYWE L P T
Sbjct:   95 ISRAGSILAKEVSDKGEFALSSGSLCETGSLFIKGLATKEEIKQRFRDQVKIFVDTGMDLLIAEYISHVQEAEWMVEVMKESGKPVAVTMAISREGDRHGVLPGECAVRLVRAGADIIGVNYRFDPERSLDTIALMQEAIQREGLKTHWMVQPLGYWCPDAGPSGITSIPECSLALDPRVLTRIEAHKFARKAYNMGVRYIGGCCGFEPYHIRALAEELANERGRFPPGSDKSCLWGKALVHHTEPQIARRANREYWENLVPAT 358          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Medaka
Match: ENSORLT00000004116.2 (betaine--homocysteine S-methyltransferase 1 [Source:NCBI gene;Acc:101157623])

HSP 1 Score: 413.69 bits (1062), Expect = 1.679e-144
Identity = 196/304 (64.47%), Postives = 234/304 (76.97%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            GA IN AAC LA++VA+EG D LV GGVSQTPSYL+   + + + IF+KQ  VF ++ VDFL+ EYFEHVEEA WAVE  KE   P+A TLCIGP+GDM+ V   ECAVRLV AGA I+GINCH DP   +K +K+M   V  AGLKAH+M+QPL + TPD + QGFIDLPEFPF LEPRI TR+DMHKYAREAY+AGIRYIGGCCGFE YHIRAVAEELA E G FP  ++KH  WG GL+MHTKPWVRARA+R+YWE L+P +GRPF  + +VPD WGVT GH EL Q  E T   ++++L+
Sbjct:   62 GAQINEAACDLAREVANEG-DALVAGGVSQTPSYLSCKSEKDVKAIFKKQLDVFVKKNVDFLIAEYFEHVEEAVWAVEMLKETGKPVAATLCIGPQGDMHGVSPQECAVRLVTAGAQIVGINCHFDPETCVKTVKMMKEGVEKAGLKAHYMVQPLAFHTPDCNCQGFIDLPEFPFGLEPRILTRWDMHKYAREAYNAGIRYIGGCCGFEPYHIRAVAEELATERGFFPAATEKHGPWGSGLEMHTKPWVRARARRDYWENLKPSSGRPFCPSLSVPDGWGVTRGHAELMQQKEATSKDQLKQLF 364          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Medaka
Match: bhmt (betaine--homocysteine S-methyltransferase 1-like [Source:NCBI gene;Acc:101175580])

HSP 1 Score: 405.216 bits (1040), Expect = 1.053e-140
Identity = 190/304 (62.50%), Postives = 232/304 (76.32%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLY 980
            G  IN AAC LA++VA+EG D LV GGVSQTPSY++   +   + IF+KQ  VF  ++VDFL+ EYFEHVEEAEWAV+  K    P+A TLCIGPEGD+N V  G+CAVRLVKAGA+I+G+NCH DP   +K +K+M   V  AGLKAH+M QPL   TPD + QGFIDLPEFPFALEPR+ TR+DMH+YAR AY+AGIRYIGGCCGFE YHIRAVAEELA E G  P  S+KH  WG GL+MHTKPWVRARA+REYWE L+P +GRPF AA + PD WG++ GH +L Q  E T + +++ ++
Sbjct:   91 GQQINEAACDLAREVANEG-DALVAGGVSQTPSYMSCESEQAVKAIFKKQIDVFIRKDVDFLIAEYFEHVEEAEWAVQILKTSGKPVAATLCIGPEGDLNGVSPGDCAVRLVKAGADIVGVNCHFDPETCVKTVKLMKEGVERAGLKAHYMSQPLALHTPDCNRQGFIDLPEFPFALEPRVLTRWDMHRYARGAYNAGIRYIGGCCGFEPYHIRAVAEELAPERGFLPPASEKHGSWGAGLEMHTKPWVRARARREYWETLKPASGRPFCAAMSKPDCWGISRGHADLMQTKEATSEAQLKAVF 393          
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Planmine SMEST
Match: SMESG000019342.1 (SMESG000019342.1)

HSP 1 Score: 654.825 bits (1688), Expect = 0.000e+0
Identity = 311/311 (100.00%), Postives = 311/311 (100.00%), Query Frame = 3
Query:   69 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQHMMKMK 1001
            GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQHMMKMK
Sbjct:   92 GANINRAACKLAKKVASEGKDVLVLGGVSQTPSYLTGIGKTNTQNIFRKQFTVFKEEEVDFLLCEYFEHVEEAEWAVETAKEFNLPIACTLCIGPEGDMNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKAHFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAGIRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPWVRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDIEIEKLYQHMMKMK 402          
The following BLAST results are available for this feature:
BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
BHMT1.221e-13660.59betaine--homocysteine S-methyltransferase [Source:... [more]
BHMT21.710e-11858.55betaine--homocysteine S-methyltransferase 2 [Sourc... [more]
BHMT23.288e-10060.26betaine--homocysteine S-methyltransferase 2 [Sourc... [more]
BHMT5.142e-8760.40betaine--homocysteine S-methyltransferase [Source:... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
bhmt3.682e-14263.07betaine-homocysteine methyltransferase [Source:NCB... [more]
bhmt5.227e-14263.07betaine-homocysteine methyltransferase [Source:NCB... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
kat6a4.489e-13660.39K(lysine) acetyltransferase 6A [Source:Xenbase;Acc... [more]
kat6a5.310e-13660.39K(lysine) acetyltransferase 6A [Source:Xenbase;Acc... [more]
kat6a8.777e-13660.39K(lysine) acetyltransferase 6A [Source:Xenbase;Acc... [more]
kat6a1.517e-13560.39K(lysine) acetyltransferase 6A [Source:Xenbase;Acc... [more]
kat6a7.240e-13560.39K(lysine) acetyltransferase 6A [Source:Xenbase;Acc... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Gm50961.399e-13558.96predicted gene 5096 [Source:MGI Symbol;Acc:MGI:364... [more]
Bhmt1.399e-13558.96betaine-homocysteine methyltransferase [Source:MGI... [more]
Bhmt23.149e-11258.03betaine-homocysteine methyltransferase 2 [Source:M... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q32LQ4|BHMT1_DANRE4.208e-14163.07Betaine--homocysteine S-methyltransferase 1 OS=Dan... [more]
sp|Q5XGM3|BHMT1_XENLA3.949e-13660.66Betaine--homocysteine S-methyltransferase 1 OS=Xen... [more]
sp|Q93088|BHMT1_HUMAN5.863e-13660.59Betaine--homocysteine S-methyltransferase 1 OS=Hom... [more]
sp|Q5RFG2|BHMT1_PONAB1.314e-13560.59Betaine--homocysteine S-methyltransferase 1 OS=Pon... [more]
sp|Q5I597|BHMT1_BOVIN2.396e-13559.28Betaine--homocysteine S-methyltransferase 1 OS=Bos... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1E1XH733.480e-15166.67Putative cysteine s-methyltransferase (Fragment) O... [more]
A0A2R5L4903.359e-15066.99Putative cysteine s-methyltransferase OS=Ornithodo... [more]
T1JFQ06.329e-14963.52Hcy-binding domain-containing protein OS=Strigamia... [more]
A0A4Y2L3D91.140e-14763.11Betaine--homocysteine S-methyltransferase 1 (Fragm... [more]
A0A1Z5LG741.335e-14766.34Hcy-binding domain-containing protein (Fragment) O... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
bhmt1.484e-14160.98betaine--homocysteine S-methyltransferase 1 [Sourc... [more]
bhmt3.867e-14160.98betaine--homocysteine S-methyltransferase 1 [Sourc... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000004959.18.915e-6163.70pep scaffold:Pmarinus_7.0:GL478860:9466:10943:1 ge... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO477431.361e-14764.47Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO488304.986e-9952.13Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO488281.517e-9550.52Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO488292.819e-8750.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSORLT00000004116.21.679e-14464.47betaine--homocysteine S-methyltransferase 1 [Sourc... [more]
bhmt1.053e-14062.50betaine--homocysteine S-methyltransferase 1-like [... [more]
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BLAST of Betaine--homocysteine S-methyltransferase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000019342.10.000e+0100.00SMESG000019342.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30035725 ID=SMED30035725|Name=Betaine--homocysteine S-methyltransferase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1042bp
TCTTCCGATCTTCTAAATTTGGGGTATCATTTTATTAAGTTACGCTAAAC
GGATACAAAATCATTTAGGGAGCAAATATAAATCGAGCCGCTTGTAAATT
AGCCAAAAAAGTTGCATCTGAAGGGAAAGATGTTTTAGTGCTTGGAGGGG
TATCACAAACACCATCGTATTTGACTGGGATTGGAAAAACGAACACTCAA
AATATATTTCGAAAACAATTTACAGTTTTTAAGGAGGAAGAAGTTGACTT
TTTGTTATGCGAATATTTTGAACATGTCGAAGAAGCTGAGTGGGCAGTTG
AAACCGCAAAGGAATTCAACTTACCTATTGCGTGCACTTTATGTATCGGA
CCCGAAGGAGATATGAACAATGTTCCCACTGGTGAATGCGCTGTAAGACT
TGTGAAGGCCGGAGCTAACATCATTGGAATAAATTGTCACAATGACCCAT
TCATTGTACTGAAAGCAATGAAAATTATGATTTCAGCAGTTCATGATGCT
GGATTAAAAGCTCACTTTATGATTCAACCGCTGGGGTACATGACGCCCGA
TAATTCAAACCAAGGATTTATAGATCTTCCAGAATTTCCGTTTGCTTTGG
AACCAAGAATTTGTACACGATTCGATATGCATAAATATGCTAGAGAGGCT
TACGATGCTGGTATCCGGTACATAGGAGGATGTTGCGGATTTGAAGCTTA
CCATATTCGAGCAGTGGCTGAAGAACTTGCGAAAGAGCATGGTAGATTTC
CTGAAGGATCAGATAAGCATGATCTATGGGGAGGAGGATTAAAAATGCAT
ACCAAACCTTGGGTGAGAGCAAGAGCCAAGAGAGAATATTGGGAAAAGTT
ACGTCCATGCACTGGTAGACCATTTGCTGCAGCATATGCCGTCCCGGATC
GATGGGGAGTAACTGCTGGTCACGATGAATTAAAACAACATGCCGAAATG
ACTGATGACATAGAAATTGAAAAGTTATATCAACACATGATGAAAATGAA
ATAAATCAATTATGTTTCACATGCTTCTGGTGCGAGATCGGA
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protein sequence of SMED30035725-orf-1

>SMED30035725-orf-1 ID=SMED30035725-orf-1|Name=SMED30035725-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=214bp
MNNVPTGECAVRLVKAGANIIGINCHNDPFIVLKAMKIMISAVHDAGLKA
HFMIQPLGYMTPDNSNQGFIDLPEFPFALEPRICTRFDMHKYAREAYDAG
IRYIGGCCGFEAYHIRAVAEELAKEHGRFPEGSDKHDLWGGGLKMHTKPW
VRARAKREYWEKLRPCTGRPFAAAYAVPDRWGVTAGHDELKQHAEMTDDI
EIEKLYQHMMKMK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000429neoblast
PLANA:0002075pigment cell
PLANA:0003116parenchymal cell
PLANA:0007528glial cell
Vocabulary: INTERPRO
TermDefinition
IPR036589HCY_dom_sf
IPR017226Betaine-hCys_S-MeTrfase_BHMT
IPR003726HCY_dom
Vocabulary: molecular function
TermDefinition
GO:0047150betaine-homocysteine S-methyltransferase activity
GO:0008270zinc ion binding
GO:0008168methyltransferase activity
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0009086methionine biosynthetic process
GO:0003323type B pancreatic cell development
GO:0006579amino-acid betaine catabolic process
GO:0032259methylation
GO:0055123digestive system development
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036589Homocysteine-binding domain superfamilyGENE3DG3DSA:3.20.20.330coord: 1..213
e-value: 9.5E-73
score: 247.4
IPR036589Homocysteine-binding domain superfamilySUPERFAMILYSSF82282Homocysteine S-methyltransferasecoord: 3..176
IPR003726Homocysteine-binding domainPFAMPF02574S-methyl_transcoord: 8..121
e-value: 6.0E-10
score: 39.4
IPR003726Homocysteine-binding domainPROSITEPS50970HCYcoord: 1..122
score: 14.115
NoneNo IPR availablePANTHERPTHR46120:SF1BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1coord: 1..208
NoneNo IPR availablePANTHERPTHR46120FAMILY NOT NAMEDcoord: 1..208