Kynureninase

Overview
NameKynureninase
Smed IDSMED30035643
Length (bp)1556
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Kynureninase (SMED30035643) t-SNE clustered cells

Violin plots show distribution of expression levels for Kynureninase (SMED30035643) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Kynureninase (SMED30035643) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Kynureninase (SMED30035643) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30035643

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymal cellSMED30035643h1SMcG0018653 dd_Smed_v4_10866_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30035643h1SMcG0022828 Contig38092newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30035643h1SMcG0022828 Contig38092uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Kynureninase vs. Ensembl Human
Match: KYNU (kynureninase [Source:HGNC Symbol;Acc:HGNC:6469])

HSP 1 Score: 378.637 bits (971), Expect = 1.754e-126
Identity = 205/460 (44.57%), Postives = 276/460 (60.00%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLL-------KTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            S++ L  +   ++++E       E  A +LD++D LR +R  F  P+  +               +YF GNSLGL P   +  + E+LDKWA     GH     PW+T DE IVG M +IVGANE E+AL+N LTVNLHL+++SF++PT +R+KIL E  AFPSDHYA +SQ++ HG + E  +  IKPRE E T   +DI+  I+  G+ IA+I  SGVHF TGQ FNI  ITK G   GC VG+DLAH VGNV L LH W VDFA WCSYKYLN+G GG+AG F+HE +      P   GW+GH+ S R +M N+ +   G   +R+SN        L  SL+IFK+  MK LR+KS+ LTGYLE L+       K      +  IITP++  ERG QL+I      + + + +E   + CD R P+ +R+AP  LYNSF+DVYK     +S+  + E
Sbjct:    4 SSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIK-PALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAE 462          
BLAST of Kynureninase vs. Ensembl Human
Match: KYNU (kynureninase [Source:HGNC Symbol;Acc:HGNC:6469])

HSP 1 Score: 378.637 bits (971), Expect = 1.754e-126
Identity = 205/460 (44.57%), Postives = 276/460 (60.00%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLL-------KTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            S++ L  +   ++++E       E  A +LD++D LR +R  F  P+  +               +YF GNSLGL P   +  + E+LDKWA     GH     PW+T DE IVG M +IVGANE E+AL+N LTVNLHL+++SF++PT +R+KIL E  AFPSDHYA +SQ++ HG + E  +  IKPRE E T   +DI+  I+  G+ IA+I  SGVHF TGQ FNI  ITK G   GC VG+DLAH VGNV L LH W VDFA WCSYKYLN+G GG+AG F+HE +      P   GW+GH+ S R +M N+ +   G   +R+SN        L  SL+IFK+  MK LR+KS+ LTGYLE L+       K      +  IITP++  ERG QL+I      + + + +E   + CD R P+ +R+AP  LYNSF+DVYK     +S+  + E
Sbjct:    4 SSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIK-PALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAE 462          
BLAST of Kynureninase vs. Ensembl Human
Match: KYNU (kynureninase [Source:HGNC Symbol;Acc:HGNC:6469])

HSP 1 Score: 273.478 bits (698), Expect = 1.181e-87
Identity = 143/291 (49.14%), Postives = 186/291 (63.92%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENN 907
            S++ L  +   ++++E       E  A +LD++D LR +R  F  P+  +               +YF GNSLGL P   +  + E+LDKWA     GH     PW+T DE IVG M +IVGANE E+AL+N LTVNLHL+++SF++PT +R+KIL E  AFPSDHYA +SQ++ HG + E  +  IKPRE E T   +DI+  I+  G+ IA+I  SGVHF TGQ FNI  ITK G   GC VG+DLAH VGNV L LH W VDFA WCSYKYLN+G GG+AG F+HE +
Sbjct:    4 SSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKH 294          
BLAST of Kynureninase vs. Ensembl Human
Match: KYNU (kynureninase [Source:HGNC Symbol;Acc:HGNC:6469])

HSP 1 Score: 207.994 bits (528), Expect = 2.734e-63
Identity = 105/227 (46.26%), Postives = 140/227 (61.67%), Query Frame = 2
Query:  101 QLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGH 748
            ++++E       E  A +LD++D LR +R  F  P+  +               +YF GNSLGL P   +  + E+LDKWA     GH     PW+T DE IVG M +IVGANE E+AL+N LTVNLHL+++SF++PT +R+KIL E  AFPSDHYA +SQ++ HG + E  +  IKPRE E T   +DI+  I+  G+ IA+I  SGVHF TGQ FNI  ITK G 
Sbjct:    6 RIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQ 232          
BLAST of Kynureninase vs. Ensembl Human
Match: KYNU (kynureninase [Source:HGNC Symbol;Acc:HGNC:6469])

HSP 1 Score: 179.874 bits (455), Expect = 1.734e-53
Identity = 85/155 (54.84%), Postives = 108/155 (69.68%), Query Frame = 2
Query:  284 VNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGH 748
            + E+LDKWA     GH     PW+T DE IVG M +IVGANE E+AL+N LTVNLHL+++SF++PT +R+KIL E  AFPSDHYA +SQ++ HG + E  +  IKPRE E T   +DI+  I+  G+ IA+I  SGVHF TGQ FNI  ITK G 
Sbjct:    8 LEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQ 162          
BLAST of Kynureninase vs. Ensembl Celegans
Match: kynu-1 (Kynureninase [Source:UniProtKB/Swiss-Prot;Acc:Q18026])

HSP 1 Score: 347.821 bits (891), Expect = 1.322e-114
Identity = 183/454 (40.31%), Postives = 260/454 (57.27%), Query Frame = 2
Query:   83 KVEEFI-QLSSENNM-ELFSEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKT-------KLNAKL-FKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLT 1381
            KV +F+ +++ E+ + +L     A +L   D+L+E R+ F +P++                 +Y  GNSLGLMP      + + LDKWA  G  GH     PW  CDE  +  +  +VGA + EV++ N LTVN+H++L SFY+PT+ R KIL E  AFPSDHYA +SQI   G   +  +V ++PRE E T   +DI+++I+ NG+EIA++  SG+ + TGQLF++  IT+ GH  GC VG+DLAH   NVPL LH W+VDFA WCSYKY  +G G + G+FVHE  L  Q      GWW H+ S R  M N     EGA  YR+SN    +   +  SLK+F +V ++ LR +S  LTGYLE L+KT       +   KL   IITP   ++RG QLS+     ++ I   +       D R P+ +R+AP  LYN++ D+ + I     + 
Sbjct:   20 KVLQFLNKMADESGIKDLTDPALAEFLSDSDALKEIRDLFHYPKAGTLPDADPSLVDPESDSIYLCGNSLGLMPKATGEVMKDHLDKWAKMGVFGHMSGEVPWAHCDEYCLEGVGRLVGAKKEEVSVCNSLTVNIHVLLTSFYKPTETRHKILLESKAFPSDHYAIESQIRLKGRTVQDSMVCLEPREGEETLRTEDILDYIEKNGDEIAIVFFSGIQYYTGQLFDMRAITEAGHRKGCFVGFDLAHAFANVPLHLHWWDVDFACWCSYKYGCTGAGSIGGLFVHERFLNDQR-ERMLGWWSHKMSSRFVMDNVLDLDEGAAGYRISNPPIHTVAAMLGSLKVFDQVSLENLRSRSCYLTGYLEYLVKTLFGENSEQRTTKLSISIITPEEFHQRGCQLSLKFSSPIDIIYPELVKRGCAVDKRYPNVIRVAPVHLYNNYVDIRRFISVLQEVA 472          
BLAST of Kynureninase vs. Ensembl Zebrafish
Match: kynu (kynureninase [Source:ZFIN;Acc:ZDB-GENE-120215-204])

HSP 1 Score: 382.874 bits (982), Expect = 1.846e-128
Identity = 193/433 (44.57%), Postives = 260/433 (60.05%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRST-----------NGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSI-PYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSS 1375
            S   A +LDQ+D LR  R  F  P+++           +   C+YF GNSLGL P N +  ++E+L+KWA  G +GH E   PW   +E +   M++IVGA   EVAL+N LTVNLHL+++SFY+PT +R KIL E  AFPSDHYA +SQI   G +    ++ IKPR+ E     +DI++ I+  G  IAL+ LSGV + +GQLF++E IT  GH  GC VG+D AH VGN  L+LH WNVDFA WC+YKY+NSG GGLAG ++HE +    SI P   GWWGH    R  M NE     G   +RLSN        L+ SL+IF +  MK LR KS+ LT YLE L++       +  +     IITP++  +RG QLS+     +  + + +E   + CD R+P+ LR+AP  LYNSF DV++ I    S
Sbjct:   18 SPTLAEHLDQRDHLRHLRELFIIPKTSQLSKVDLSLVDSSEDCIYFAGNSLGLQPKNTKKYIDEELEKWAKTGVHGHTEGSRPWAWAEETLEEMMAKIVGAKTEEVALMNGLTVNLHLLMLSFYKPTPKRHKILLEDKAFPSDHYAIESQIRLRGLNMSDSMLIIKPRQGEDVIRTEDIVSLIEREGESIALVMLSGVQYYSGQLFDMETITTAGHSKGCFVGFDCAHAVGNAELRLHDWNVDFACWCTYKYMNSGAGGLAGAYIHERH--AHSIKPALTGWWGHDLKTRFLMNNEMDLQPGVNGFRLSNQPILLVCPLQASLEIFNQTTMKDLRSKSVLLTAYLEFLIRHYYSRDPSDPDRPSVHIITPSDPQQRGCQLSLSFSSPIRAVFEELEKRGVACDMREPNVLRVAPVPLYNSFTDVHRFITVLGS 448          
BLAST of Kynureninase vs. Ensembl Zebrafish
Match: kynu (kynureninase [Source:ZFIN;Acc:ZDB-GENE-120215-204])

HSP 1 Score: 367.466 bits (942), Expect = 5.320e-122
Identity = 193/462 (41.77%), Postives = 260/462 (56.28%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRST-----------NGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDH-----------------------------YAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSI-PYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSS 1375
            S   A +LDQ+D LR  R  F  P+++           +   C+YF GNSLGL P N +  ++E+L+KWA  G +GH E   PW   +E +   M++IVGA   EVAL+N LTVNLHL+++SFY+PT +R KIL E  AFPSDH                             YA +SQI   G +    ++ IKPR+ E     +DI++ I+  G  IAL+ LSGV + +GQLF++E IT  GH  GC VG+D AH VGN  L+LH WNVDFA WC+YKY+NSG GGLAG ++HE +    SI P   GWWGH    R  M NE     G   +RLSN        L+ SL+IF +  MK LR KS+ LT YLE L++       +  +     IITP++  +RG QLS+     +  + + +E   + CD R+P+ LR+AP  LYNSF DV++ I    S
Sbjct:   18 SPTLAEHLDQRDHLRHLRELFIIPKTSQLSKVDLSLVDSSEDCIYFAGNSLGLQPKNTKKYIDEELEKWAKTGVHGHTEGSRPWAWAEETLEEMMAKIVGAKTEEVALMNGLTVNLHLLMLSFYKPTPKRHKILLEDKAFPSDHVCKKNTSITQSLINHMVKACFSAFVLIFQYAIESQIRLRGLNMSDSMLIIKPRQGEDVIRTEDIVSLIEREGESIALVMLSGVQYYSGQLFDMETITTAGHSKGCFVGFDCAHAVGNAELRLHDWNVDFACWCTYKYMNSGAGGLAGAYIHERH--AHSIKPALTGWWGHDLKTRFLMNNEMDLQPGVNGFRLSNQPILLVCPLQASLEIFNQTTMKDLRSKSVLLTAYLEFLIRHYYSRDPSDPDRPSVHIITPSDPQQRGCQLSLSFSSPIRAVFEELEKRGVACDMREPNVLRVAPVPLYNSFTDVHRFITVLGS 477          
BLAST of Kynureninase vs. Ensembl Xenopus
Match: ift20 (intraflagellar transport 20 [Source:Xenbase;Acc:XB-GENE-966387])

HSP 1 Score: 369.392 bits (947), Expect = 1.350e-122
Identity = 198/466 (42.49%), Postives = 268/466 (57.51%), Query Frame = 2
Query:   86 VEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR----STNGRQ-------CLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQL---------TVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHE---NNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAK-------LFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            +E    ++S+    L  E  A +LD QD L+  R  F  P+     T  +        C+Y  GNSLGL+P   +  ++E+LDKWA  G +GHF    PW  CDE IV  M+ IVG  +     +  L              L+L+SFYRPTK+R+KIL E  AFPSDHYA +SQI  HG D    ++ + PR+ E T   +DI++ I+ +G+ IA+I  SGV + TGQLF++E+IT+ GH+ GC VG+DLAH VGNV L LH W VDFA WCSYKYLNSG GGLAG F+H+   N +K    P   GWWGH    R +M NE + + G   +R+SN        L  SL++F +  MK LR+KSI LTGYLE L+K   +           KI+TP+N  ERG QLS+     ++ + + +E   + CD R+P  LR+AP  LYN+F+DVY+ I+         E
Sbjct:   11 LETLGDIASQLGYSLQDEKLALHLDDQDELKHLRQCFHVPKIKDIPTTDKSLVNEEDDCVYLCGNSLGLLPKTVKPYIDEELDKWAKMGVHGHFTGKRPWALCDECIVDLMATIVGMFKYIYLWIKHLLCGQNSFYQIATFGLLLLSFYRPTKDRYKILLEAKAFPSDHYAVESQIRLHGLDVGKSMLLLYPRKGEDTLRTEDILSVIEEDGDSIAVILFSGVQYYTGQLFDMEKITEAGHKKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAGAFLHKKHSNTIK----PTLMGWWGHDFKTRFKMENEMELSPGINGFRISNPPILLVCSLHASLEVFNQTTMKALRKKSILLTGYLEQLIKYYFSKSTEGPQKPYAKILTPSNVKERGCQLSLTFSLPIKAVFEELEKRGVVCDMREPHGLRIAPVPLYNTFHDVYRFIQILGQAIAAVE 472          
BLAST of Kynureninase vs. Ensembl Xenopus
Match: ift20 (intraflagellar transport 20 [Source:Xenbase;Acc:XB-GENE-966387])

HSP 1 Score: 355.525 bits (911), Expect = 1.757e-117
Identity = 194/457 (42.45%), Postives = 263/457 (57.55%), Query Frame = 2
Query:   86 VEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR----STNGRQ-------CLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHE---NNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK------TKLNAKLF-KIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            +E    ++S+    L  E  A +LD QD L+  R  F  P+     T  +        C+Y  GNSLGL+P   +  ++E+LDKWA  G +GHF    PW  CDE IV  M+ IVG  +     +  L             PTK+R+KIL E  AFPSDHYA +SQI  HG D    ++ + PR+ E T   +DI++ I+ +G+ IA+I  SGV + TGQLF++E+IT+ GH+ GC VG+DLAH VGNV L LH W VDFA WCSYKYLNSG GGLAG F+H+   N +K    P   GWWGH    R +M NE + + G   +R+SN        L  SL++F +  MK LR+KSI LTGYLE L+K      T+   K + KI+TP+N  ERG QLS+     ++ + + +E   + CD R+P  LR+AP  LYN+F+DVY+ I+         E
Sbjct:   17 LETLGDIASQLGYSLQDEKLALHLDDQDELKHLRQCFHVPKIKDIPTTDKSLVNEEDDCVYLCGNSLGLLPKTVKPYIDEELDKWAKMGVHGHFTGKRPWALCDECIVDLMATIVGMFKYIYLWIKHLL------------PTKDRYKILLEAKAFPSDHYAVESQIRLHGLDVGKSMLLLYPRKGEDTLRTEDILSVIEEDGDSIAVILFSGVQYYTGQLFDMEKITEAGHKKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAGAFLHKKHSNTIK----PTLMGWWGHDFKTRFKMENEMELSPGINGFRISNPPILLVCSLHASLEVFNQTTMKALRKKSILLTGYLEQLIKYYFSKSTEGPQKPYAKILTPSNVKERGCQLSLTFSLPIKAVFEELEKRGVVCDMREPHGLRIAPVPLYNTFHDVYRFIQILGQAIAAVE 457          
BLAST of Kynureninase vs. Ensembl Xenopus
Match: ift20 (intraflagellar transport 20 [Source:Xenbase;Acc:XB-GENE-966387])

HSP 1 Score: 348.977 bits (894), Expect = 7.338e-115
Identity = 197/459 (42.92%), Postives = 266/459 (57.95%), Query Frame = 2
Query:   86 VEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR----STNGRQ-------CLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSF--YRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHE---NNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK------TKLNAKLF-KIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            +E    ++S+    L  E  A +LD QD L+  R  F  P+     T  +        C+Y  GNSLGL+P   +  ++E+LDKWA  G +GHF    PW  CDE IV  M         ++A    L + L L L SF    PTK+R+KIL E  AFPSDHYA +SQI  HG D    ++ + PR+ E T   +DI++ I+ +G+ IA+I  SGV + TGQLF++E+IT+ GH+ GC VG+DLAH VGNV L LH W VDFA WCSYKYLNSG GGLAG F+H+   N +K    P   GWWGH    R +M NE + + G   +R+SN        L  SL++F +  MK LR+KSI LTGYLE L+K      T+   K + KI+TP+N  ERG QLS+     ++ + + +E   + CD R+P  LR+AP  LYN+F+DVY+ I+         E
Sbjct:   11 LETLGDIASQLGYSLQDEKLALHLDDQDELKHLRQCFHVPKIKDIPTTDKSLVNEEDDCVYLCGNSLGLLPKTVKPYIDEELDKWAKMGVHGHFTGKRPWALCDECIVDLMD-----YGKDIASFFFLILTLLLYLKSFIILPPTKDRYKILLEAKAFPSDHYAVESQIRLHGLDVGKSMLLLYPRKGEDTLRTEDILSVIEEDGDSIAVILFSGVQYYTGQLFDMEKITEAGHKKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAGAFLHKKHSNTIK----PTLMGWWGHDFKTRFKMENEMELSPGINGFRISNPPILLVCSLHASLEVFNQTTMKALRKKSILLTGYLEQLIKYYFSKSTEGPQKPYAKILTPSNVKERGCQLSLTFSLPIKAVFEELEKRGVVCDMREPHGLRIAPVPLYNTFHDVYRFIQILGQAIAAVE 460          
BLAST of Kynureninase vs. Ensembl Xenopus
Match: ift20 (intraflagellar transport 20 [Source:Xenbase;Acc:XB-GENE-966387])

HSP 1 Score: 293.508 bits (750), Expect = 3.356e-95
Identity = 150/318 (47.17%), Postives = 201/318 (63.21%), Query Frame = 2
Query:  470 YRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHE---NNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK------TKLNAKLF-KIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            Y PTK+R+KIL E  AFPSDHYA +SQI  HG D    ++ + PR+ E T   +DI++ I+ +G+ IA+I  SGV + TGQLF++E+IT+ GH+ GC VG+DLAH VGNV L LH W VDFA WCSYKYLNSG GGLAG F+H+   N +K    P   GWWGH    R +M NE + + G   +R+SN        L  SL++F +  MK LR+KSI LTGYLE L+K      T+   K + KI+TP+N  ERG QLS+     ++ + + +E   + CD R+P  LR+AP  LYN+F+DVY+ I+         E
Sbjct:    4 YMPTKDRYKILLEAKAFPSDHYAVESQIRLHGLDVGKSMLLLYPRKGEDTLRTEDILSVIEEDGDSIAVILFSGVQYYTGQLFDMEKITEAGHKKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAGAFLHKKHSNTIK----PTLMGWWGHDFKTRFKMENEMELSPGINGFRISNPPILLVCSLHASLEVFNQTTMKALRKKSILLTGYLEQLIKYYFSKSTEGPQKPYAKILTPSNVKERGCQLSLTFSLPIKAVFEELEKRGVVCDMREPHGLRIAPVPLYNTFHDVYRFIQILGQAIAAVE 317          
BLAST of Kynureninase vs. Ensembl Mouse
Match: Kynu (kynureninase [Source:MGI Symbol;Acc:MGI:1918039])

HSP 1 Score: 395.201 bits (1014), Expect = 3.863e-133
Identity = 212/460 (46.09%), Postives = 277/460 (60.22%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR-----------STNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            S + L V+   ++++E N +   E  A  LD++D L  +RN F  P+            +     +YF GNSLGL P   R  + E+LDKWA  G  GH     PW+  DE IV  M +IVGA+E E+AL+N LT+NLHL+L+SF++PT +R KIL E  AFPSDHYA +SQI+ HG D E  +  +KPRE E T   +DI+  I+  G+ IA+I  SG+HF TGQLFNI  ITK GH  GC VG+DLAH VGNV L+LH W VDFA WCSYKYLNSG GGLAG FVHE +      P   GW+GH  S R  M N+ +   GA  +R+SN        L  SL++F++  M  LR KSI LTGYLE +LK       T+    +  IITP+   ERG QL++      + + K +E   + CD R+P  +R+AP  LYNSF+DVYK I   +S+  + E
Sbjct:    5 SPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSIDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAKMGAYGHDVGKRPWIVGDESIVSLMKDIVGAHEKEIALMNALTINLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMVKPREGEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAKGCFVGFDLAHAVGNVELRLHDWGVDFACWCSYKYLNSGAGGLAGAFVHEKHAHTVK-PALVGWFGHDLSTRFNMDNKLQLIPGANGFRISNPPILLVCSLHASLEVFQQATMTALRRKSILLTGYLEYMLKHYHSKDNTENKGPIVNIITPSRAEERGCQLTLTFSIPKKSVFKELEKRGVVCDKREPDGIRVAPVPLYNSFHDVYKFIRLLTSILDSSE 463          
BLAST of Kynureninase vs. Ensembl Mouse
Match: Kynu (kynureninase [Source:MGI Symbol;Acc:MGI:1918039])

HSP 1 Score: 354.755 bits (909), Expect = 9.994e-118
Identity = 191/403 (47.39%), Postives = 245/403 (60.79%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR-----------STNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSI 1222
            S + L V+   ++++E N +   E  A  LD++D L  +RN F  P+            +     +YF GNSLGL P   R  + E+LDKWA  G  GH     PW+  DE IV  M +IVGA+E E+AL+N LT+NLHL+L+SF++PT +R KIL E  AFPSDHYA +SQI+ HG D E  +  +KPRE E T   +DI+  I+  G+ IA+I  SG+HF TGQLFNI  ITK GH  GC VG+DLAH VGNV L+LH W VDFA WCSYKYLNSG GGLAG FVHE +      P   GW+GH  S R  M N+ +   GA  +R+SN        L  SL++F++  M  LR KSI LTGYLE +LK       T+    +  IITP+   ERG QL++
Sbjct:    5 SPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSIDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAKMGAYGHDVGKRPWIVGDESIVSLMKDIVGAHEKEIALMNALTINLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMVKPREGEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAKGCFVGFDLAHAVGNVELRLHDWGVDFACWCSYKYLNSGAGGLAGAFVHEKHAHTVK-PALVGWFGHDLSTRFNMDNKLQLIPGANGFRISNPPILLVCSLHASLEVFQQATMTALRRKSILLTGYLEYMLKHYHSKDNTENKGPIVNIITPSRAEERGCQLTL 406          
BLAST of Kynureninase vs. Ensembl Mouse
Match: Kynu (kynureninase [Source:MGI Symbol;Acc:MGI:1918039])

HSP 1 Score: 288.5 bits (737), Expect = 1.777e-93
Identity = 149/291 (51.20%), Postives = 188/291 (64.60%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR-----------STNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENN 907
            S + L V+   ++++E N +   E  A  LD++D L  +RN F  P+            +     +YF GNSLGL P   R  + E+LDKWA  G  GH     PW+  DE IV  M +IVGA+E E+AL+N LT+NLHL+L+SF++PT +R KIL E  AFPSDHYA +SQI+ HG D E  +  +KPRE E T   +DI+  I+  G+ IA+I  SG+HF TGQLFNI  ITK GH  GC VG+DLAH VGNV L+LH W VDFA WCSYKYLNSG GGLAG FVHE +
Sbjct:    5 SPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSIDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAKMGAYGHDVGKRPWIVGDESIVSLMKDIVGAHEKEIALMNALTINLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMVKPREGEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAKGCFVGFDLAHAVGNVELRLHDWGVDFACWCSYKYLNSGAGGLAGAFVHEKH 295          
BLAST of Kynureninase vs. UniProt/SwissProt
Match: sp|Q1DDU5|KYNU_MYXXD (Kynureninase OS=Myxococcus xanthus (strain DK 1622) OX=246197 GN=kynU PE=3 SV=1)

HSP 1 Score: 413.69 bits (1062), Expect = 5.744e-140
Identity = 197/410 (48.05%), Postives = 259/410 (63.17%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIE 1363
            SE FA  LD +D+LR YR+ F FP   +G+  +Y  GNSLGL P NA   + E+L+ WA  G  GH     PWL   E +    + +VGA   EV ++N L+VNLHLM+VSFYRPTK+RFKIL E  AFPSD YA  SQ+ +HGYD    ++ +KPRE E T   +DI+  I+ +G+E+AL+ L  V++LTGQ F++  ITK  H  GC VG+DLAH  GN+ L LH    DFAVWCSYKYLN+GPG L G+FVHE +   + +P F+GWWGH    R +M   F    GA  ++LSN        L  SL++F + GM  LR KS +LTGYLE LL  +L     +I TP +  +RG+QLS+   G+ + + K + D  I CDFRKP  +R AP  LYNSF DVY+ ++
Sbjct:   10 SESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYIQEELEDWARLGVEGHHHGRHPWLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVSFYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAVLELKPREGEETLRTEDILETIERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGPDFAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGAEGWQLSNPPIFQLAALRASLELFDQAGMAALRAKSERLTGYLEFLLD-RLPEGFVRITTPRDVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIRAAPAPLYNSFTDVYRFVK 418          
BLAST of Kynureninase vs. UniProt/SwissProt
Match: sp|Q1ITW5|KYNU_KORVE (Kynureninase OS=Koribacter versatilis (strain Ellin345) OX=204669 GN=kynU PE=3 SV=1)

HSP 1 Score: 394.815 bits (1013), Expect = 1.121e-132
Identity = 187/413 (45.28%), Postives = 263/413 (63.68%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILI-MGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAF 1369
            +E+FA  +D +D +  +R +F  P + +G   +Y  G+SLGL P   R  + ++L  W   G  GHF    PW+     +    + +V A  +EV ++N LTVNLHLM+VSFYRPT+ER  IL E +AFPSD YA QSQI++HG+DP   L+ + PR  E+T  ++DI+  I+  G  IALI L GV++ TGQ F++ EITK GH  GC+V +D AH  GN+ L+LH W+VD+A WCSYKYLN GPG + G FVHE   +   +P F GWWGH    R +M  EF P  GA  ++LSN S  +   L  S++IF E G+ KLR++SI LTGYLE LL  + +A+ F+IITP     RG+QLSI +  G+    ++++E+  + CD+R+P  LR+AP  LY S+ D Y+ ++ F
Sbjct:    9 TENFAIEMDARDPMSRFRGRFHIPPAPDGSASVYLVGHSLGLQPKTVRAYLEQELKDWETLGVEGHFRGKHPWMPYHRLLTEQTARLVCAQPSEVVVMNSLTVNLHLMMVSFYRPTRERHNILIEGSAFPSDQYAVQSQIKFHGFDPASSLLELCPRVGEATMRDEDILELIEREGQSIALILLGGVNYATGQAFDMAEITKAGHAQGCVVAFDCAHAAGNLELKLHEWDVDWAAWCSYKYLNGGPGCIGGCFVHERYARDFELPRFAGWWGHDQETRFKMGPEFHPMAGAEGWQLSNPSILTMAALRASMEIFDEAGIGKLRQRSIALTGYLEFLLDQQKSAR-FEIITPREPERRGAQLSIRVAAGNRSVCDRLVEEGAL-CDWREPDILRVAPVPLYCSYRDCYRFVQRF 419          
BLAST of Kynureninase vs. UniProt/SwissProt
Match: sp|A6H1P7|KYNU_FLAPJ (Kynureninase OS=Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511) OX=402612 GN=kynU PE=3 SV=1)

HSP 1 Score: 394.815 bits (1013), Expect = 1.211e-132
Identity = 191/406 (47.04%), Postives = 264/406 (65.02%), Query Frame = 2
Query:  140 DFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK--TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVY 1351
            +FA  LD QD L+EY+N+F FP+   G+  +YF GNSLGL P +AR  V+E ++ WAN    GHF    PW    E     +S+IVGA   EV ++N LTVNLHL++VSFYRPTK+R+KI+CE  AFPSD Y FQSQ+ +HGY PE  +V IK RE E     +DI++ I+  G+E+AL+   GV++ TGQ+F+++ IT+ GH+ G  VG+DLAH  GN+ L+LH WNVDFA WCSYKY+NSGPG  +G FVHE +    ++P F GWWGH    R +M   F P  GA  +++SN+   S      S+++F EVG++KL  K  ++T YLE +L    K     F+I+TP N+ ER  QLS+ + G+   +   +  N +  D+R+P+ +RLAP  LY SF D+Y
Sbjct:    8 EFAQQLDNQDELKEYKNEFIFPQH-EGKNVIYFTGNSLGLQPKSARNYVDEVMNDWANLAVEGHFYADKPWWDYQERFANPLSKIVGAKPLEVTVMNTLTVNLHLLMVSFYRPTKKRYKIICEEKAFPSDQYMFQSQVNFHGYKPEDAIVEIKRREGEHNIRLEDILSKIEAVGDELALVLFGGVNYYTGQVFDMKTITEAGHKQGAKVGFDLAHAAGNIKLELHDWNVDFAAWCSYKYMNSGPGNASGCFVHEKHHSDSNLPRFAGWWGHNKERRFKMEPTFDPVHGADGWQISNLPILSLAPYLASVEMFAEVGIEKLIRKRNQITAYLEFILHEIDKEVKGHFEILTPTNQEERACQLSVFLHGEGRSLFDYLMKNGVVTDWREPNVIRLAPVPLYCSFEDMY 412          
BLAST of Kynureninase vs. UniProt/SwissProt
Match: sp|Q9CXF0|KYNU_MOUSE (Kynureninase OS=Mus musculus OX=10090 GN=Kynu PE=1 SV=3)

HSP 1 Score: 395.201 bits (1014), Expect = 2.853e-132
Identity = 212/460 (46.09%), Postives = 277/460 (60.22%), Query Frame = 2
Query:   68 SNMSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPR-----------STNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            S + L V+   ++++E N +   E  A  LD++D L  +RN F  P+            +     +YF GNSLGL P   R  + E+LDKWA  G  GH     PW+  DE IV  M +IVGA+E E+AL+N LT+NLHL+L+SF++PT +R KIL E  AFPSDHYA +SQI+ HG D E  +  +KPRE E T   +DI+  I+  G+ IA+I  SG+HF TGQLFNI  ITK GH  GC VG+DLAH VGNV L+LH W VDFA WCSYKYLNSG GGLAG FVHE +      P   GW+GH  S R  M N+ +   GA  +R+SN        L  SL++F++  M  LR KSI LTGYLE +LK       T+    +  IITP+   ERG QL++      + + K +E   + CD R+P  +R+AP  LYNSF+DVYK I   +S+  + E
Sbjct:    4 SPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSIDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAKMGAYGHDVGKRPWIVGDESIVSLMKDIVGAHEKEIALMNALTINLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMVKPREGEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAKGCFVGFDLAHAVGNVELRLHDWGVDFACWCSYKYLNSGAGGLAGAFVHEKHAHTVK-PALVGWFGHDLSTRFNMDNKLQLIPGANGFRISNPPILLVCSLHASLEVFQQATMTALRRKSILLTGYLEYMLKHYHSKDNTENKGPIVNIITPSRAEERGCQLTLTFSIPKKSVFKELEKRGVVCDKREPDGIRVAPVPLYNSFHDVYKFIRLLTSILDSSE 462          
BLAST of Kynureninase vs. UniProt/SwissProt
Match: sp|A9V3C0|KYNU_MONBE (Kynureninase OS=Monosiga brevicollis OX=81824 GN=kynu PE=3 SV=1)

HSP 1 Score: 390.193 bits (1001), Expect = 2.379e-130
Identity = 193/449 (42.98%), Postives = 269/449 (59.91%), Query Frame = 2
Query:   98 IQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQ-----------CLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEE---PFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVS----------FYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLN----AKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVI 1360
            + L+ E  + L  +  A  LD+ D L   R +FS P+  + +Q           C+Y  GNSLGLMP   R  VNE+LD WA  G  GHF +     PW++ DE +    + +VGA   EVA++N LTVNLHL++VS          FYRPT +RFKIL E  AFPSDH+A  SQ+  HG+D E  L+ +KPRE E     +D++  ++  G+ IA + + GVH+ TGQ F+++ +    H  GC  G DLAH VGNVPLQLH W++DFA WC+YKYLNSGPGG+AG F+H+ + +  S PY +GWWG Q ++R  M ++     G    +LSN      + L  SL+I+++  M  LR KS+KLT YLE L++  +N    A  F+IITP +   RG QLSIL   D++   + +E   + CD R+P  +R+AP  LYN+F DVY+ +
Sbjct:    1 MHLARELGVNLADQRLAQALDEADPLAHLRQEFSIPQMKDIKQADLKLVEAESDCIYLCGNSLGLMPKRTRTIVNEELDTWATGGVTGHFPDGPGKRPWVSIDETVTDKCARVVGALPEEVAIMNTLTVNLHLLMVSLAHTMARQVPFYRPTSDRFKILVEAKAFPSDHFAVLSQLRMHGHD-ESALIEVKPREGEHNIREEDLLAILEEQGDSIATVLVGGVHYYTGQFFDLQRLCAAAHNKGCTFGVDLAHAVGNVPLQLHDWDIDFACWCTYKYLNSGPGGIAGAFIHKKH-EGTSRPYLQGWWGVQLNERFRMDHDASFMPGVRGLQLSNPGVLQTVALLGSLEIYEQTDMASLRAKSLKLTAYLEQLMQALVNEEGHAPRFEIITPTDPERRGCQLSILFKVDIDAAFEALEKRGVVCDVRRPDVMRIAPVPLYNTFTDVYRFV 447          
BLAST of Kynureninase vs. TrEMBL
Match: A0A4P9XQZ4 (Kynureninase OS=Thamnocephalis sphaerospora OX=78915 GN=BNA5 PE=3 SV=1)

HSP 1 Score: 440.654 bits (1132), Expect = 7.644e-148
Identity = 206/439 (46.92%), Postives = 288/439 (65.60%), Query Frame = 2
Query:   77 SLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPF--PWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTT 1387
            SL ++    ++ E  +++ S+ FA  +D +D L   R++F+ P++ +G   +Y  GNSLGL+P  A+  V E+   WA  G  GH +     PW+T DE +VG  + IVGA   EVA++  LT NLH ++VSFYRPT +R+KIL E  AFPSD YA +SQI++HGYDP   +V ++PRE E T  ++DI+  I+ +G+EIAL+   GV + TGQLF+I+ IT+  H  GC  G+DLAH  GNVPL+LH W VDFA WCSYKYLNSGPG +AGIFVHE +    ++P   GWWGH+ + R +M++EF P+ GA  Y+ SN S  + + L  SL++F+  GM++LREKS+ LTGYLE LL+  +     KIITP + +ERG QLSIL+  DV+ +   +    + CD RKP+ +RL P  LYNSF DV++  E    + T 
Sbjct:    4 SLPIDSLQSVAQEMGVDVRSKAFAREMDARDKLAPLRDEFAIPKAQDGNDAVYLCGNSLGLLPKRAQTLVAEEFQVWAESGVIGHHQHRHGRPWVTIDEQVVGKSATIVGAKPAEVAVMGTLTANLHFLMVSFYRPTAQRYKILLEKRAFPSDTYAVKSQIQFHGYDPTTAMVALEPREGEYTLRHEDILAAIEEHGDEIALVLFPGVQYYTGQLFDIQGITEAAHRKGCYAGFDLAHAAGNVPLRLHDWQVDFACWCSYKYLNSGPGSIAGIFVHEQHFDNPALPRLTGWWGHEKTTRFDMSDEFTPSPGAAVYQHSNPSVLNTVCLLGSLQVFERAGMEQLREKSLLLTGYLEFLLQDLVQKFNMKIITPRSPSERGCQLSILLDCDVDTVFPQMMAAGLICDERKPNCIRLGPTPLYNSFTDVHRAAEIICRVMTA 442          
BLAST of Kynureninase vs. TrEMBL
Match: A0A522D7J2 (Kynureninase OS=Alphaproteobacteria bacterium OX=1913988 GN=kynU PE=3 SV=1)

HSP 1 Score: 437.187 bits (1123), Expect = 1.087e-146
Identity = 209/413 (50.61%), Postives = 271/413 (65.62%), Query Frame = 2
Query:  146 ANY---LDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSS 1375
            ANY   LD +D L  +R +F  P++  G  C+Y  GNSLGL P     AV ++L+ W   G  GHF    PWL   E +   ++ +VGA  +EV ++N LTVNLHLM+VSFYRPT ERFKIL E ++FPSD YA +SQI +HG+DP   L+ +KPRE E+T   DD+  FI   G  IALI + GV + TGQLF++  ITK GH  GCMVG+DLAH  GN  L LH W+VDFA WCSYKYLNSGPG +AG FVHE + K  ++P F GWWGH  + R +M  EF+P EGA  ++LSN    SF     SL++F+E GM++LREKS KLTGYLE LLK      L KI+TPAN  ERG QLSI +     R+  V+    + CD+R+P  +R+AP  LYN+++DV+  +  F++
Sbjct:    8 ANYMRRLDGEDKLARFRKQFHIPKTKAGEDCVYLCGNSLGLQPKGVEPAVRQELEDWKTLGVEGHFHAKHPWLPYHEPLTSLVAGVVGAKPSEVVMMNGLTVNLHLMMVSFYRPTPERFKILIEGSSFPSDRYAVESQIRFHGFDPAAALLELKPREGEATLRMDDVEAFIDKEGASIALILIGGVQYYTGQLFDMARITKAGHRRGCMVGFDLAHAAGNAVLDLHDWDVDFACWCSYKYLNSGPGSVAGCFVHERHAKAFNLPRFAGWWGHDKTTRFKMGPEFRPMEGAEGWQLSNPPILSFAASRASLELFREAGMERLREKSEKLTGYLEFLLKEAQLPGL-KILTPANPAERGCQLSITLEEGGRRVFDVLTTTGVVCDWREPDCIRIAPVPLYNTYSDVFNFVRVFAA 419          
BLAST of Kynureninase vs. TrEMBL
Match: A0A3D8MVF7 (Kynureninase OS=Bradymonadaceae bacterium TMQ3 OX=2283320 GN=kynU PE=3 SV=1)

HSP 1 Score: 429.483 bits (1103), Expect = 6.923e-144
Identity = 200/411 (48.66%), Postives = 272/411 (66.18%), Query Frame = 2
Query:  122 MELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYK 1354
            M++   D+A  LD++D L  +R +F  P   +G   LY  GNSLGL P   + A+ E+L+KWA+ G +GHF EP PW +  E     M+ +VGA   EV ++N LT NLHL++VSFYRP+ ERFKIL E  AFPSD YA QSQ  +HG+DP   +V + PR+ E T  ++DII+ I+  G+E+AL+   GV++ TGQLF++  IT+ GH  G MVG+DLAH  GN PL+LH W  DFA WCSYKYLNSGPGG+AG+FVHE +L +  +P F+GWWG   + R EM   F+P  GA  ++LSN        L  SL++F E  M+ LR+KS KLTGYL  L+ T + A  F++ITPA+   RG QLSIL  GD E + K +    + CD+R+P+ +R+AP  LYN++ DV++
Sbjct:    1 MKITDLDYARQLDREDPLGTFRERFHIPTGRSGEPVLYLCGNSLGLQPRGVQKALGEELEKWAHLGVDGHFAEPNPWYSYHEIFSKPMAAVVGAQPEEVVVMNSLTTNLHLLMVSFYRPSAERFKILIEGGAFPSDLYAVQSQARFHGFDPAETIVELYPRDGEKTLRDEDIIDAIEREGDELALVLFGGVNYYTGQLFDMGAITRAGHRAGAMVGFDLAHAAGNAPLKLHDWGADFAAWCSYKYLNSGPGGVAGVFVHERHLGRNDLPRFEGWWGTDPNTRFEMGPSFEPQYGAGAWQLSNAPILPMASLRASLELFTEASMEALRDKSEKLTGYLYELI-TSMGAGAFEVITPADPERRGCQLSILAAGDGESLHKRLMAADVVCDYRRPNVIRVAPTPLYNTYEDVWR 410          
BLAST of Kynureninase vs. TrEMBL
Match: A0A5C6UYE6 (Kynureninase OS=Bradymonadales bacterium TMQ1 OX=2600174 GN=kynU PE=3 SV=1)

HSP 1 Score: 429.483 bits (1103), Expect = 6.923e-144
Identity = 200/411 (48.66%), Postives = 272/411 (66.18%), Query Frame = 2
Query:  122 MELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYK 1354
            M++   D+A  LD++D L  +R +F  P   +G   LY  GNSLGL P   + A+ E+L+KWA+ G +GHF EP PW +  E     M+ +VGA   EV ++N LT NLHL++VSFYRP+ ERFKIL E  AFPSD YA QSQ  +HG+DP   +V + PR+ E T  ++DII+ I+  G+E+AL+   GV++ TGQLF++  IT+ GH  G MVG+DLAH  GN PL+LH W  DFA WCSYKYLNSGPGG+AG+FVHE +L +  +P F+GWWG   + R EM   F+P  GA  ++LSN        L  SL++F E  M+ LR+KS KLTGYL  L+ T + A  F++ITPA+   RG QLSIL  GD E + K +    + CD+R+P+ +R+AP  LYN++ DV++
Sbjct:    1 MKITDLDYARQLDREDPLGTFRERFHIPTGRSGEPVLYLCGNSLGLQPRGVQKALGEELEKWAHLGVDGHFAEPNPWYSYHEIFSKPMAAVVGAQPEEVVVMNSLTTNLHLLMVSFYRPSAERFKILIEGGAFPSDLYAVQSQARFHGFDPAETIVELYPRDGEKTLRDEDIIDAIEREGDELALVLFGGVNYYTGQLFDMGAITRAGHRAGAMVGFDLAHAAGNAPLKLHDWGADFAAWCSYKYLNSGPGGVAGVFVHERHLGRNDLPRFEGWWGTDPNTRFEMGPSFEPQYGAGAWQLSNAPILPMASLRASLELFTEASMEALRDKSEKLTGYLYELI-TSMGAGAFEVITPADPERRGCQLSILAAGDGESLHKRLMAADVVCDYRRPNVIRVAPTPLYNTYEDVWR 410          
BLAST of Kynureninase vs. TrEMBL
Match: A0A5C6XEJ2 (Kynureninase OS=Bradymonadales bacterium TMQ4 OX=2600176 GN=kynU PE=3 SV=1)

HSP 1 Score: 427.943 bits (1099), Expect = 2.785e-143
Identity = 200/411 (48.66%), Postives = 271/411 (65.94%), Query Frame = 2
Query:  122 MELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYK 1354
            M++   D+A  LD++D L  +R +F  P  + G   LY  GNSLGL P     A+ E+L+KWAN G +GHF EP PW +  E     M+ +VGA   EV ++N LT NLHL++VSFYRP+ ERFKIL E  AFPSD YA QSQ  +HG+DP   +V + PR+ E T  ++DI+  I+  G+ +AL+   GV++ TGQLF++  IT+ GH+ G MVG+DLAH  GN PL+LH W  DFA WCSYKYLNSGPGG+AG+FVHE +L ++ IP F+GWWG   + R EM   F P  GA  ++LSN        L  SL++F E GM+ LR+KS KLTGYL  L+ T + A  F++ITP+  + RG QLSIL  GD E + K +    + CD+R+P+ +R+AP  LYN++ DV++
Sbjct:    1 MKITDLDYARQLDREDPLGGFRQRFHIPTGSAGDPVLYLCGNSLGLQPKGVEKALGEELEKWANLGVDGHFAEPNPWYSYHEIFNAPMAAVVGARPEEVVVMNSLTTNLHLLMVSFYRPSAERFKILIEGGAFPSDLYAVQSQARFHGFDPAEAIVELYPRDGEKTLRDEDILAAIEREGDRLALVLFGGVNYYTGQLFDMGAITEAGHKAGAMVGFDLAHAAGNAPLKLHDWGPDFAAWCSYKYLNSGPGGVAGVFVHERHLGRKDIPRFEGWWGTDPNTRFEMGPSFAPQYGAGAWQLSNAPVLPMASLRASLELFTEAGMEALRQKSEKLTGYLYELV-TSIGADAFEVITPSEPDRRGCQLSILAAGDGELLHKRLMAADVICDYRRPNVIRVAPTPLYNTYEDVWR 410          
BLAST of Kynureninase vs. Ensembl Cavefish
Match: kynu (kynureninase [Source:NCBI gene;Acc:103034460])

HSP 1 Score: 386.341 bits (991), Expect = 9.034e-130
Identity = 201/432 (46.53%), Postives = 261/432 (60.42%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAK-------LFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSS 1375
            S + A Y D+ D LR  R +F FP+                 C+YF GNSLGL P N +  ++E+L KWA  G +GH     PW   + D+   M+++VGA   EVAL+N LTVNLHL+L++FY+P   R KIL E  AFPSDHYA +SQI   G+DP   ++ +KPR  E T   +DI++ I+  G+ IA++ LSGV + TGQLFN+E ITK G   GC VG+D AH VGN  L+LH W VDFA WC+YKY+NSG GGLAG F+HE ++ +   P   GWWGH    R +MTNE     G   YRLSN        L+ SL+IF +  MK LR+KSI LTGYLE LLK   + K          IITP+N  ERG QLS+     +  + K +E   + CD R+P+ LR+AP  LYNSF+DV++ I    S
Sbjct:   26 SREVAEYFDKNDKLRHLRQEFLFPKVAQLPTSDLSLVGGSEDCIYFVGNSLGLQPKNVKKYIDEELKKWATIGAHGHVMGSRPWAWAENDLEDLMAKVVGAKPEEVALMNGLTVNLHLLLLAFYQPIATRHKILLEDKAFPSDHYAVESQIRLRGFDPSTSMLFVKPRPGEDTLRTEDIVSTIEREGHSIAVVMLSGVQYYTGQLFNMEVITKAGQNQGCYVGFDCAHAVGNADLRLHDWGVDFACWCTYKYVNSGAGGLAGAFIHEKHVDRVK-PALLGWWGHNLKTRFQMTNEMDLQPGVNGYRLSNQPVLLVCPLQASLEIFNQTTMKDLRKKSILLTGYLEYLLKHYYSKKASDPHKPCVHIITPSNPAERGCQLSLSFSLPIRAVFKELEKRGVACDMREPNVLRVAPVPLYNSFSDVHRFITVLGS 456          
BLAST of Kynureninase vs. Ensembl Cavefish
Match: kynu (kynureninase [Source:NCBI gene;Acc:103034460])

HSP 1 Score: 386.341 bits (991), Expect = 9.034e-130
Identity = 201/432 (46.53%), Postives = 261/432 (60.42%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAK-------LFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSS 1375
            S + A Y D+ D LR  R +F FP+                 C+YF GNSLGL P N +  ++E+L KWA  G +GH     PW   + D+   M+++VGA   EVAL+N LTVNLHL+L++FY+P   R KIL E  AFPSDHYA +SQI   G+DP   ++ +KPR  E T   +DI++ I+  G+ IA++ LSGV + TGQLFN+E ITK G   GC VG+D AH VGN  L+LH W VDFA WC+YKY+NSG GGLAG F+HE ++ +   P   GWWGH    R +MTNE     G   YRLSN        L+ SL+IF +  MK LR+KSI LTGYLE LLK   + K          IITP+N  ERG QLS+     +  + K +E   + CD R+P+ LR+AP  LYNSF+DV++ I    S
Sbjct:   26 SREVAEYFDKNDKLRHLRQEFLFPKVAQLPTSDLSLVGGSEDCIYFVGNSLGLQPKNVKKYIDEELKKWATIGAHGHVMGSRPWAWAENDLEDLMAKVVGAKPEEVALMNGLTVNLHLLLLAFYQPIATRHKILLEDKAFPSDHYAVESQIRLRGFDPSTSMLFVKPRPGEDTLRTEDIVSTIEREGHSIAVVMLSGVQYYTGQLFNMEVITKAGQNQGCYVGFDCAHAVGNADLRLHDWGVDFACWCTYKYVNSGAGGLAGAFIHEKHVDRVK-PALLGWWGHNLKTRFQMTNEMDLQPGVNGYRLSNQPVLLVCPLQASLEIFNQTTMKDLRKKSILLTGYLEYLLKHYYSKKASDPHKPCVHIITPSNPAERGCQLSLSFSLPIRAVFKELEKRGVACDMREPNVLRVAPVPLYNSFSDVHRFITVLGS 456          
BLAST of Kynureninase vs. Ensembl Cavefish
Match: kynu (kynureninase [Source:NCBI gene;Acc:103034460])

HSP 1 Score: 269.24 bits (687), Expect = 2.057e-86
Identity = 132/272 (48.53%), Postives = 174/272 (63.97%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKK 916
            S + A Y D+ D LR  R +F FP+                 C+YF GNSLGL P N +  ++E+L KWA  G +GH     PW   + D+   M+++VGA   EVAL+N LTVNLHL+L++FY+P   R KIL E  AFPSDHYA +SQI   G+DP   ++ +KPR  E T   +DI++ I+  G+ IA++ LSGV + TGQLFN+E ITK G   GC VG+D AH VGN  L+LH W VDFA WC+YKY+NSG GGLAG F+HE ++ +
Sbjct:   26 SREVAEYFDKNDKLRHLRQEFLFPKVAQLPTSDLSLVGGSEDCIYFVGNSLGLQPKNVKKYIDEELKKWATIGAHGHVMGSRPWAWAENDLEDLMAKVVGAKPEEVALMNGLTVNLHLLLLAFYQPIATRHKILLEDKAFPSDHYAVESQIRLRGFDPSTSMLFVKPRPGEDTLRTEDIVSTIEREGHSIAVVMLSGVQYYTGQLFNMEVITKAGQNQGCYVGFDCAHAVGNADLRLHDWGVDFACWCTYKYVNSGAGGLAGAFIHEKHVDR 297          
BLAST of Kynureninase vs. Ensembl Sea Lamprey
Match: kynu (kynureninase [Source:ZFIN;Acc:ZDB-GENE-120215-204])

HSP 1 Score: 365.925 bits (938), Expect = 2.009e-122
Identity = 180/433 (41.57%), Postives = 256/433 (59.12%), Query Frame = 2
Query:  134 SEDFANYLDQQDSLREYRNKFSFPRSTN-------------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGH--EMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKS-----IKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFS 1372
            S   A +LD  DSLR +R  F  PR  +              ++C+Y  GNSLGLMP   R  + E+L KWA  G  GH E   PW  CDE +  +M+ IVGA  +EVA++N L++NLHL++++FY+PT +R+KI+ E  +FPSD+YA +SQI   G+DPE  ++ I PR+ E T   +D++  ++  G+ IAL+   GV + TGQLF++  IT   H  E GC+VG+DLAH VGNV + LH W VDFA WCSYKYLNSG GGLAG F+HE ++   + P   GWWGH+   R++M N+ + + G   +R+SN        LE SLKIF E  M  LR KS           L +  ++       ++ITP++  +RG QLS+     +  +   ++   + CD R+P  LR+AP  LYNSF DV++ +   +
Sbjct:   26 SRRLAEHLDATDSLRGFRESFHVPRMRDLSAVDKSLLEGDMDQECVYLAGNSLGLMPRAVRTVLEEELHKWATTGVYGHHEGARPWALCDEILTANMATIVGAEAHEVAVMNGLSINLHLLMLAFYKPTAQRYKIMLEAKSFPSDYYAMESQIRLRGHDPEKTMLQILPRQGEETLRPEDVLEILEREGDSIALVLFGGVQYYTGQLFDMPAITHAAHTKEQGCLVGFDLAHAVGNVEIFLHEWQVDFACWCSYKYLNSGAGGLAGAFIHEKHMNTIN-PVLIGWWGHKYETRMKMDNKLQLSAGVSGFRISNPPILLVCPLEASLKIFVEASMPALRAKSRLLTGYLELLLLTLFAESPKGGASVRLITPSDPEQRGCQLSLSFSIPIGVVYHELKRRGVVCDMREPFVLRVAPTPLYNSFQDVWRFVHTLA 457          
BLAST of Kynureninase vs. Ensembl Yeast
Match: BNA5 (Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000004221])

HSP 1 Score: 352.443 bits (903), Expect = 1.776e-117
Identity = 182/431 (42.23%), Postives = 269/431 (62.41%), Query Frame = 2
Query:  185 RNKFSFPR------STNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEP------FPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGY-DPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEM-GCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLK----KQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEV-GMKKLREKSIKLTGYLEMLLKTKLNAK----------LFKIITP-ANENERGSQLSILIMGD------VERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAF 1369
            R++F+ P       S++ +   Y  GNSLGLMP + R ++N +LD W++     HF+ P       PW++ D  I+  ++ IVGA ENEVA++N LT NL+ +L++FY+PT++RFKIL E  +FPSD+YAF +Q + HG  +PE   + I+PRE E+     DI++ I+ N +E+AL+CLSGV + TGQ F+I  IT   H+    +VGWDLAH VGNVPLQLH W VDFA WCSYKYLN+GPGG+ G+FVH  + K    K+S+P   GWWG+  + R +M   F+P  GAL +R SN S    + L +SL++F +  G+ ++R++S+ LT Y+  LL+     K           F I+TP + + E G+QLS+    D      + ++ + + D+ +  D R+P+ +RLAP  LYN+F+DVY  + A 
Sbjct:   16 RDEFNIPTFKSMGLSSDDKPVTYLCGNSLGLMPKSTRNSINAELDAWSDCAVESHFKHPEEARGKVPWVSIDLPILPLLAPIVGAQENEVAVMNSLTANLNSLLITFYKPTEKRFKILFEKGSFPSDYYAFYNQCKIHGISEPENVFIQIEPREGETYIRTQDILDTIEVNQDELALVCLSGVQYYTGQYFDIGRITSFAHQFPDILVGWDLAHAVGNVPLQLHDWGVDFACWCSYKYLNAGPGGIGGLFVHSKHTKPDPAKESLPRLAGWWGNDPAKRFQMLEVFEPIPGALGFRQSNPSVIDTVALRSSLELFAKFNGINEVRKRSLLLTNYMTELLEASKYYKHPLRIEKLPCFFTILTPTSTDEEHGAQLSLYFDSDTGKEDIMPKVFQYLHDHGVIGDARRPNVIRLAPAPLYNTFSDVYIAVNAL 446          
BLAST of Kynureninase vs. Ensembl Nematostella
Match: KYNU (Kynureninase [Source:UniProtKB/Swiss-Prot;Acc:A7SCH8])

HSP 1 Score: 371.318 bits (952), Expect = 2.602e-124
Identity = 191/452 (42.26%), Postives = 274/452 (60.62%), Query Frame = 2
Query:  101 QLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRS----------TNGRQ-CLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEML----------LKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIE----AFSSLT 1381
            +L+ ++++++ S +FA+Y+D +D LR+ R++F +PR            +G Q  +YF GNSLGL P   R  ++  L KW   G  GH     PW   ++ ++  M+EI+GA + EV  +N LTVNLH+M+V FYRPT +R+KIL E  AFPSD YA QSQ+ +HG+DP+  ++ + PRE E +   +DI++ I+ +GN I L+  SGV + TGQ F+++ IT    + GC+VGWDLAH VGNV L LH WNVDFA WC+YKYLNSGPGG+AG FVHE +     +P F GWWG   + R +M  EF+   GA  Y+ SN      +LL  SL +F++  +K++R K   LT YLE+L          +    N     IITPA+  +RG QLS+     V+++ + +       D R P  +R+AP  LYNSF DV++ I     AF ++T
Sbjct:   11 KLAEKSSLDIVSREFADYMDSKDPLRKMRDEFFYPRVKDLPGVDLSLVDGDQDSIYFCGNSLGLQPRGCRELIDRSLTKWEQMGVLGHTSGWCPWKPIEDILIKPMAEIIGAKDIEVVAMNTLTVNLHMMMVPFYRPTPQRYKILMEGKAFPSDQYAAQSQVHFHGFDPDKDIIEVFPREGEQSLRTEDILSAIEEHGNSITLVLFSGVQYYTGQFFDMKTITAAAQKKGCVVGWDLAHAVGNVELHLHDWNVDFACWCTYKYLNSGPGGIAGAFVHEKHAYNFELPKFAGWWGTDRNSRFQMRKEFEQIPGAHGYQCSNPPVFQCLLLRASLDVFEKTSVKEIRAKGDLLTAYLELLLLHYFSPSNDITKNGNTPHVSIITPADPKDRGCQLSVKFSVPVDKVFEELCKRGFVGDIRHPDVMRIAPAPLYNSFADVHRFISMLNAAFKTIT 462          
BLAST of Kynureninase vs. Ensembl Nematostella
Match: EDO27148 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TA23])

HSP 1 Score: 201.06 bits (510), Expect = 1.674e-61
Identity = 91/216 (42.13%), Postives = 143/216 (66.20%), Query Frame = 2
Query:  713 LFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK---TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVY 1351
            +F+I+ IT  G ++G  VGWDLAH  GN+ L+L+ WNVDFA WCSYKY+NSGPG ++G FVHE +   + +  F GW+GH    R  M ++F+P +GA  +++SN+   S      S+++F E+GM+++ +K   +T YLE +L     ++ +  F+IITPAN+ ERG QLS+ + G  + + + + +N +  D+R+P+ +RLAP  LY S+ D+Y
Sbjct:    1 VFDIKTITAAGQKVGAYVGWDLAHAAGNIELKLNEWNVDFAAWCSYKYMNSGPGNVSGYFVHEKHHNDKGLSRFAGWYGHNKERRFLMESQFEPVQGANGWQISNLPVLSMAPYLASVEMFAEIGMQQIIKKRSLITSYLEFILHEIDKEVESAEFEIITPANQEERGCQLSVYLHGQGKELFQYLMENGVITDWREPNVIRLAPVPLYTSYEDMY 216          
BLAST of Kynureninase vs. Ensembl Medaka
Match: kynu (kynureninase [Source:NCBI gene;Acc:101174251])

HSP 1 Score: 380.178 bits (975), Expect = 2.564e-127
Identity = 190/427 (44.50%), Postives = 259/427 (60.66%), Query Frame = 2
Query:  146 ANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSI-PYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAF 1369
            A Y D+ D LR  R  F  P+  +           G +C+Y  GNSLGL P   R  + E+LDKWA  G +GH +   PW   + +I   M+++VGA  +EVAL+N LTVNLHL+++SFY+PT+ R K+L E  AFPSDHYA +SQI   G +P+  ++ + PRE E T    DI+  I+  G+ IA++ LSGV + TGQLF++  IT+ GH+ GC VG+D AH  GNV L+LH W VDFA WCSYKYLNSG GGLA  FVHE +  + SI P   GWWGH    R +MTN  +   G   +RLSN        L+ SL++F    M+ LR KS+ LTGYLE L++        +      +IITP++  +RG QLS+     + ++ + +E   + CD R+P+ LR+AP  LYNSFNDV++ I   
Sbjct:   30 AAYFDENDDLRHLRQHFLMPKVADLPASDLSLVDGGEECIYLCGNSLGLQPKMTRKYLEEELDKWARTGVHGHTDGSRPWAWAENNIEDLMAKVVGAKTSEVALMNGLTVNLHLLMLSFYKPTQSRHKVLLEAKAFPSDHYAVESQIRLRGLNPQHSMLMLSPREGEETLRTADILEAIEKEGDSIAVVMLSGVQYYTGQLFDMASITQAGHQKGCFVGFDCAHAAGNVELKLHDWGVDFACWCSYKYLNSGAGGLAAAFVHEKH--QHSIQPALLGWWGHNLQTRFQMTNVMELQPGVSGFRLSNQPILLVCPLQASLEVFNLTNMQALRRKSVLLTGYLENLIQHYFSEDPAEPRKPHVRIITPSDPQQRGCQLSLAFSVPIRKVFQELERRGVVCDMREPNVLRIAPTPLYNSFNDVHRFISTL 454          
BLAST of Kynureninase vs. Ensembl Medaka
Match: kynu (kynureninase [Source:NCBI gene;Acc:101174251])

HSP 1 Score: 306.99 bits (785), Expect = 5.308e-99
Identity = 163/418 (39.00%), Postives = 230/418 (55.02%), Query Frame = 2
Query:  146 ANYLDQQDSLREYRNKFSFPRSTN-----------GRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEF------KPAEGALKYRLSNVSFTSFILLETSLKIFKE-----VGMKKLREKSIKLTGYLEMLLK-------TKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRL 1312
            A Y D+ D LR  R  F  P+  +           G +C+Y  GNSLGL P   R  + E+LDKWA  G +GH +   PW   + +I   M+++VGA  +EVAL+N LTVNLHL+++SFY+PT+ R K+L E  AFPSDHYA +SQI   G +P+  ++ + PRE E T    DI+  I+  G+ IA++ LSGV + TGQLF++  IT+ GH+ GC VG+D AH  GNV L+LH W VDFA WCSYKYLNSG GGLA  FVHE +       +    W    S+RL             P +   K +L  +      LL+ +  +F         M+ LR KS+ LTGYLE L++        +      +IITP++  +RG QLS+     + ++ + +E   +     + +   L
Sbjct:   30 AAYFDENDDLRHLRQHFLMPKVADLPASDLSLVDGGEECIYLCGNSLGLQPKMTRKYLEEELDKWARTGVHGHTDGSRPWAWAENNIEDLMAKVVGAKTSEVALMNGLTVNLHLLMLSFYKPTQSRHKVLLEAKAFPSDHYAVESQIRLRGLNPQHSMLMLSPREGEETLRTADILEAIEKEGDSIAVVMLSGVQYYTGQLFDMASITQAGHQKGCFVGFDCAHAAGNVELKLHDWGVDFACWCSYKYLNSGAGGLAAAFVHEKHQHSIQPAHGAAAW----SERLPPVKSAHSAGLPPPGQSGGKLKLPALQMMGPHLLKAAPAVFHPQVFNLTNMQALRRKSVLLTGYLENLIQHYFSEDPAEPRKPHVRIITPSDPQQRGCQLSLAFSVPIRKVFQELERRGVVVSVTRTAAQHL 443          
BLAST of Kynureninase vs. Planmine SMEST
Match: SMESG000026221.1 (SMESG000026221.1)

HSP 1 Score: 913.294 bits (2359), Expect = 0.000e+0
Identity = 440/440 (100.00%), Postives = 440/440 (100.00%), Query Frame = 2
Query:   74 MSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 1393
            MSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE
Sbjct:    1 MSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTNGRQCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE 440          
BLAST of Kynureninase vs. Planmine SMEST
Match: SMESG000043996.1 (SMESG000043996.1)

HSP 1 Score: 392.889 bits (1008), Expect = 2.101e-132
Identity = 196/461 (42.52%), Postives = 290/461 (62.91%), Query Frame = 2
Query:   65 LSNMSLKVEEFIQL-SSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTN------GR-----QCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDIVGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFPSDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIALICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWNVDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLEMTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLTGYLEMLLKT---KLNAKLFKIITPANENERGSQLSILIMG-DVERIEKVIEDNYICCDFRKPSTLRLAPCALYNSFNDV---YKVIEAFSSLTTTE 1390
            ++++ + +EE + L S+E ++ +    FA  +D +D +   R +F +P+         G+       +Y  GNSLGLMP  A+  +++ L +W++ G  GH     PW  CDE+++  M+ +VGA+ +EVA++NQLT +LH ML++FYRPT+ R+KIL E  +FPSD+YAF+SQ   HG DP   L+ +KPR+ E     +DI+  I+ +G EI++IC SG  + TGQ FNI  IT  GH++G  VGWDLAH+VGN+ L LH W+VDFAVW +YKYLN+G G     F+H + L   ++PY  GWWGH    R++MTN  +P  G  KYR+S  S      L ++LKIF  V MK +R KSI LT YL+ LL +   ++   + ++ITP ++ ERG+QLS+   G  ++ I   +++N + CD RKP+ +R+A C LYNSF DV   Y+VI +F S  + E
Sbjct:    1 MNDIRMDLEESLSLVSTELDLHINDRRFALAMDARDPMAPVRTRFEYPKMKQLPFVDLGKVDAEEDSIYLAGNSLGLMPKAAKEELDQFLKQWSDYGVYGHHYGEHPWYICDEELLPRMARLVGASTDEVAIMNQLTSSLHFMLLTFYRPTQSRYKILFEDKSFPSDYYAFESQALLHGLDPNDALLAVKPRQGEHCLRLEDILQMIRNHGTEISVICFSGTQYYTGQHFNIPAITSCGHQVGAFVGWDLAHSVGNIELDLHEWDVDFAVWTTYKYLNAGAGNTGAAFLH-SRLFSSNLPYLSGWWGHDIETRMQMTNIMEPGRGIRKYRMSTPSALHCAALRSALKIFDMVNMKSVRRKSILLTEYLDRLLNSINVEVGENVLQVITPRDKEERGAQLSVSFSGIHLDDIHTFLKENGVVCDQRKPNVIRMAACPLYNSFLDVFRAYEVILSFVSCRSME 460          
The following BLAST results are available for this feature:
BLAST of Kynureninase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
KYNU1.754e-12644.57kynureninase [Source:HGNC Symbol;Acc:HGNC:6469][more]
KYNU1.754e-12644.57kynureninase [Source:HGNC Symbol;Acc:HGNC:6469][more]
KYNU1.181e-8749.14kynureninase [Source:HGNC Symbol;Acc:HGNC:6469][more]
KYNU2.734e-6346.26kynureninase [Source:HGNC Symbol;Acc:HGNC:6469][more]
KYNU1.734e-5354.84kynureninase [Source:HGNC Symbol;Acc:HGNC:6469][more]
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BLAST of Kynureninase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
kynu-11.322e-11440.31Kynureninase [Source:UniProtKB/Swiss-Prot;Acc:Q18... [more]
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BLAST of Kynureninase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Kynureninase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
kynu1.846e-12844.57kynureninase [Source:ZFIN;Acc:ZDB-GENE-120215-204][more]
kynu5.320e-12241.77kynureninase [Source:ZFIN;Acc:ZDB-GENE-120215-204][more]
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BLAST of Kynureninase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ift201.350e-12242.49intraflagellar transport 20 [Source:Xenbase;Acc:XB... [more]
ift201.757e-11742.45intraflagellar transport 20 [Source:Xenbase;Acc:XB... [more]
ift207.338e-11542.92intraflagellar transport 20 [Source:Xenbase;Acc:XB... [more]
ift203.356e-9547.17intraflagellar transport 20 [Source:Xenbase;Acc:XB... [more]
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BLAST of Kynureninase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Kynu3.863e-13346.09kynureninase [Source:MGI Symbol;Acc:MGI:1918039][more]
Kynu9.994e-11847.39kynureninase [Source:MGI Symbol;Acc:MGI:1918039][more]
Kynu1.777e-9351.20kynureninase [Source:MGI Symbol;Acc:MGI:1918039][more]
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BLAST of Kynureninase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q1DDU5|KYNU_MYXXD5.744e-14048.05Kynureninase OS=Myxococcus xanthus (strain DK 1622... [more]
sp|Q1ITW5|KYNU_KORVE1.121e-13245.28Kynureninase OS=Koribacter versatilis (strain Elli... [more]
sp|A6H1P7|KYNU_FLAPJ1.211e-13247.04Kynureninase OS=Flavobacterium psychrophilum (stra... [more]
sp|Q9CXF0|KYNU_MOUSE2.853e-13246.09Kynureninase OS=Mus musculus OX=10090 GN=Kynu PE=1... [more]
sp|A9V3C0|KYNU_MONBE2.379e-13042.98Kynureninase OS=Monosiga brevicollis OX=81824 GN=k... [more]
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BLAST of Kynureninase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4P9XQZ47.644e-14846.92Kynureninase OS=Thamnocephalis sphaerospora OX=789... [more]
A0A522D7J21.087e-14650.61Kynureninase OS=Alphaproteobacteria bacterium OX=1... [more]
A0A3D8MVF76.923e-14448.66Kynureninase OS=Bradymonadaceae bacterium TMQ3 OX=... [more]
A0A5C6UYE66.923e-14448.66Kynureninase OS=Bradymonadales bacterium TMQ1 OX=2... [more]
A0A5C6XEJ22.785e-14348.66Kynureninase OS=Bradymonadales bacterium TMQ4 OX=2... [more]
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BLAST of Kynureninase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
kynu9.034e-13046.53kynureninase [Source:NCBI gene;Acc:103034460][more]
kynu9.034e-13046.53kynureninase [Source:NCBI gene;Acc:103034460][more]
kynu2.057e-8648.53kynureninase [Source:NCBI gene;Acc:103034460][more]
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BLAST of Kynureninase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
kynu2.009e-12241.57kynureninase [Source:ZFIN;Acc:ZDB-GENE-120215-204][more]
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BLAST of Kynureninase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
BNA51.776e-11742.23Kynureninase; required for the de novo biosynthesi... [more]
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BLAST of Kynureninase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
KYNU2.602e-12442.26Kynureninase [Source:UniProtKB/Swiss-Prot;Acc:A7S... [more]
EDO271481.674e-6142.13Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Kynureninase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
kynu2.564e-12744.50kynureninase [Source:NCBI gene;Acc:101174251][more]
kynu5.308e-9939.00kynureninase [Source:NCBI gene;Acc:101174251][more]
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BLAST of Kynureninase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000026221.10.000e+0100.00SMESG000026221.1[more]
SMESG000043996.12.101e-13242.52SMESG000043996.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30035643 ID=SMED30035643|Name=Kynureninase|organism=Schmidtea mediterranea sexual|type=transcript|length=1556bp
GCTGAATTCCATATCATTGAAATGCATTAATATAATGACTGAAATCGTCA
TTAAATAATTTATTTTATCAAATATGTCATTGAAAGTCGAAGAATTTATA
CAATTATCGTCAGAAAATAATATGGAACTATTTTCTGAAGATTTCGCTAA
TTATTTGGATCAACAAGATTCTCTCCGAGAATATAGAAATAAGTTCTCTT
TCCCGAGATCTACAAATGGAAGGCAATGCCTGTATTTCAATGGGAATTCT
TTGGGGTTGATGCCTATAAATGCAAGAATCGCAGTTAACGAACAATTAGA
TAAATGGGCTAACAGAGGTGGCAATGGTCATTTTGAAGAACCTTTTCCAT
GGTTAACTTGCGATGAAGACATAGTAGGAGACATGTCAGAAATTGTCGGT
GCTAACGAAAACGAAGTCGCATTATTAAATCAACTCACTGTCAATCTTCA
CTTGATGCTTGTTTCATTTTACAGACCTACAAAAGAAAGATTTAAAATTT
TATGTGAACATAATGCTTTTCCATCGGATCATTACGCATTTCAATCACAA
ATCGAATGGCACGGTTACGATCCAGAGATCGGTTTGGTTACTATTAAACC
ACGCGAGAATGAAAGCACTTGGCTAAATGATGATATAATTAATTTTATTA
AAACAAATGGAAATGAAATTGCTTTGATATGTTTAAGTGGAGTTCACTTT
TTAACTGGTCAGCTGTTTAATATTGAAGAAATCACGAAGGTCGGACATGA
AATGGGTTGCATGGTAGGTTGGGACTTGGCTCACACAGTTGGCAATGTAC
CTTTGCAACTTCATTTATGGAATGTCGATTTTGCAGTTTGGTGTTCGTAT
AAATATTTAAACAGTGGGCCAGGTGGACTTGCAGGAATTTTTGTGCATGA
AAACAACTTGAAAAAGCAAAGTATCCCATATTTTAAAGGTTGGTGGGGTC
ATCAATCTTCTGATAGACTCGAAATGACAAATGAATTCAAACCAGCAGAG
GGGGCTTTAAAATACCGATTATCCAATGTTTCTTTCACTAGTTTCATTTT
ATTGGAGACTTCTCTTAAAATATTCAAAGAAGTTGGAATGAAAAAATTAA
GAGAAAAATCAATCAAGTTGACAGGATATTTAGAAATGCTATTAAAGACA
AAGCTCAACGCAAAACTCTTTAAGATAATCACTCCGGCTAATGAAAATGA
AAGAGGTTCTCAATTATCAATTTTGATAATGGGGGATGTTGAAAGAATAG
AAAAGGTAATTGAAGACAATTATATTTGTTGTGATTTTCGAAAGCCTTCA
ACGTTAAGACTGGCCCCATGCGCTCTTTACAATTCATTTAACGACGTTTA
TAAAGTTATTGAAGCATTCTCAAGTTTAACAACAACAGAAGAATAAATTA
TATGGAAATTATTTATAAACGAACCAAATTTTTATAACAAGTTTTACGAA
TTTTTAAAATTTTATCAATAAAACTTTTAACAGATATATATTATCCATCT
ATTATTGTAACCTTGAAATTCACTAGTGTTTTATTTAAATATATATAACA
AGGCAG
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protein sequence of SMED30035643-orf-1

>SMED30035643-orf-1 ID=SMED30035643-orf-1|Name=SMED30035643-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=441bp
MSLKVEEFIQLSSENNMELFSEDFANYLDQQDSLREYRNKFSFPRSTNGR
QCLYFNGNSLGLMPINARIAVNEQLDKWANRGGNGHFEEPFPWLTCDEDI
VGDMSEIVGANENEVALLNQLTVNLHLMLVSFYRPTKERFKILCEHNAFP
SDHYAFQSQIEWHGYDPEIGLVTIKPRENESTWLNDDIINFIKTNGNEIA
LICLSGVHFLTGQLFNIEEITKVGHEMGCMVGWDLAHTVGNVPLQLHLWN
VDFAVWCSYKYLNSGPGGLAGIFVHENNLKKQSIPYFKGWWGHQSSDRLE
MTNEFKPAEGALKYRLSNVSFTSFILLETSLKIFKEVGMKKLREKSIKLT
GYLEMLLKTKLNAKLFKIITPANENERGSQLSILIMGDVERIEKVIEDNY
ICCDFRKPSTLRLAPCALYNSFNDVYKVIEAFSSLTTTEE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0019805quinolinate biosynthetic process
GO:0034354'de novo' NAD biosynthetic process from tryptophan
GO:0043420anthranilate metabolic process
GO:0009435NAD biosynthetic process
GO:0006569tryptophan catabolic process
GO:0019363pyridine nucleotide biosynthetic process
GO:0097053L-kynurenine catabolic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002089reproductive organ
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR015422PyrdxlP-dep_Trfase_dom1
IPR010111Kynureninase
IPR000192Aminotrans_V_dom
IPR015421PyrdxlP-dep_Trfase_major
IPR015424PyrdxlP-dep_Trfase
Vocabulary: molecular function
TermDefinition
GO:0003824catalytic activity
GO:0030429kynureninase activity
GO:0030170pyridoxal phosphate binding
GO:0016787hydrolase activity
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR010111KynureninaseTIGRFAMTIGR01814TIGR01814coord: 26..434
e-value: 5.2E-130
score: 431.9
IPR010111KynureninasePIRSFPIRSF038800KYNUcoord: 17..440
e-value: 6.1E-151
score: 500.4
IPR010111KynureninasePANTHERPTHR14084KYNURENINASEcoord: 8..437
IPR000192Aminotransferase class V domainPFAMPF00266Aminotran_5coord: 193..385
e-value: 3.2E-13
score: 49.4
IPR015422Pyridoxal phosphate-dependent transferase domain 1GENE3DG3DSA:3.90.1150.10coord: 25..430
e-value: 3.0E-169
score: 564.8
IPR015421Pyridoxal phosphate-dependent transferase, major domainGENE3DG3DSA:3.40.640.10coord: 64..337
e-value: 3.0E-169
score: 564.8
NoneNo IPR availablePANTHERPTHR14084:SF0KYNURENINASEcoord: 8..437
IPR015424Pyridoxal phosphate-dependent transferaseSUPERFAMILYSSF53383PLP-dependent transferasescoord: 23..433