SMED30035597
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035597 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of SMED30035597 vs. Ensembl Human
Match: PAK1 (p21 (RAC1) activated kinase 1 [Source:HGNC Symbol;Acc:HGNC:8590]) HSP 1 Score: 368.237 bits (944), Expect = 4.422e-121 Identity = 212/492 (43.09%), Postives = 287/492 (58.33%), Query Frame = -2
Query: 204 KFFKNL----KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGL--KPVAE----------------EKTPPEI---------------------------VETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP---SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++++ K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F Y K ++ DK N L K V+E + TPP + V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P +P+ K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 53 RFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEF---YNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE-KLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA 537
BLAST of SMED30035597 vs. Ensembl Human
Match: PAK2 (p21 (RAC1) activated kinase 2 [Source:HGNC Symbol;Acc:HGNC:8591]) HSP 1 Score: 358.992 bits (920), Expect = 1.042e-117 Identity = 202/448 (45.09%), Postives = 271/448 (60.49%), Query Frame = -2
Query: 204 EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEE-----------KTPPEIV-ETENQKKLETNT-----STPV--------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1448
EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F D +K+L +D +G P N A PP I ++ K + T + PV ++KK KM+D E L IV+ +P KY E++G GASGTV AT G +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++S+L+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 73 EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY-DSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAA 516
BLAST of SMED30035597 vs. Ensembl Human
Match: PAK1 (p21 (RAC1) activated kinase 1 [Source:HGNC Symbol;Acc:HGNC:8590]) HSP 1 Score: 355.14 bits (910), Expect = 2.436e-116 Identity = 203/472 (43.01%), Postives = 275/472 (58.26%), Query Frame = -2
Query: 261 KFFKNL----KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGL--KPVAE----------------EKTPPEI---------------------------VETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKH 1499
+F++++ K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F Y K ++ DK N L K V+E + TPP + V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H
Sbjct: 53 RFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEF---YNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQH 518
BLAST of SMED30035597 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592]) HSP 1 Score: 353.214 bits (905), Expect = 2.552e-115 Identity = 205/481 (42.62%), Postives = 283/481 (58.84%), Query Frame = -2
Query: 204 KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYE----EKHEKFL-GNKENY----EDKDETGEPRDNGLKPVAE------------EKTPPEIV--ETENQKKLET-------------------------NTSTPVK---RKKNK--MSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1481
K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F E +K+ F G+K + T + L P E PP ++ E+ K + T N+ST + R++ K M+D E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL+FLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + ++ FL+ CLE+D + R SA+ LL+H FLK K L ++ I AA
Sbjct: 57 KTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 534
BLAST of SMED30035597 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592]) HSP 1 Score: 353.214 bits (905), Expect = 2.991e-115 Identity = 205/481 (42.62%), Postives = 283/481 (58.84%), Query Frame = -2
Query: 204 KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYE----EKHEKFL-GNKENY----EDKDETGEPRDNGLKPVAE------------EKTPPEIV--ETENQKKLET-------------------------NTSTPVK---RKKNK--MSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1481
K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F E +K+ F G+K + T + L P E PP ++ E+ K + T N+ST + R++ K M+D E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL+FLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + ++ FL+ CLE+D + R SA+ LL+H FLK K L ++ I AA
Sbjct: 58 KTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 535
BLAST of SMED30035597 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 325.865 bits (834), Expect = 1.552e-106 Identity = 159/296 (53.72%), Postives = 215/296 (72.64%), Query Frame = -2
Query: 204 KNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1085
+ K+SD+E L EIV NPL KYE+ +++G GASGTV +A + + VA+K M QP ++++LTEIKVMKQ +HPN+VNYIES+L+ D +LWVV++YL+GG LTDVV +T +D G IA+V++ECL AL FLH ++I+HRDIKSDNVLLG +G+VK+TD GFCAQ+ S+R T+VGTPYWM+PE++N+ QY+ K+DIWSLGIM +EM+DGEPPY+ ETPLKAIY I G+P K ++ + +FL CL +DP+ R LL H FLK+ K L ++ I A
Sbjct: 131 REKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDAD-DLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPEILNKK-QYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRAV 423
BLAST of SMED30035597 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 327.405 bits (838), Expect = 5.380e-105 Identity = 159/295 (53.90%), Postives = 215/295 (72.88%), Query Frame = -2
Query: 207 KNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDA 1085
+ K+SD+E L EIV NPL KYE+ +++G GASGTV +A + + VA+K M QP ++++LTEIKVMKQ +HPN+VNYIES+L+ D +LWVV++YL+GG LTDVV +T +D G IA+V++ECL AL FLH ++I+HRDIKSDNVLLG +G+VK+TD GFCAQ+ S+R T+VGTPYWM+PE++N+ QY+ K+DIWSLGIM +EM+DGEPPY+ ETPLKAIY I G+P K ++ + +FL CL +DP+ R LL H FLK+ K L ++ I A
Sbjct: 306 REKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDAD-DLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPEILNKK-QYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRA 597
BLAST of SMED30035597 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 327.405 bits (838), Expect = 5.461e-105 Identity = 159/295 (53.90%), Postives = 215/295 (72.88%), Query Frame = -2
Query: 207 KNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDA 1085
+ K+SD+E L EIV NPL KYE+ +++G GASGTV +A + + VA+K M QP ++++LTEIKVMKQ +HPN+VNYIES+L+ D +LWVV++YL+GG LTDVV +T +D G IA+V++ECL AL FLH ++I+HRDIKSDNVLLG +G+VK+TD GFCAQ+ S+R T+VGTPYWM+PE++N+ QY+ K+DIWSLGIM +EM+DGEPPY+ ETPLKAIY I G+P K ++ + +FL CL +DP+ R LL H FLK+ K L ++ I A
Sbjct: 303 REKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDAD-DLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPEILNKK-QYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRA 594
BLAST of SMED30035597 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 327.405 bits (838), Expect = 1.685e-104 Identity = 159/295 (53.90%), Postives = 215/295 (72.88%), Query Frame = -2
Query: 207 KNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDA 1085
+ K+SD+E L EIV NPL KYE+ +++G GASGTV +A + + VA+K M QP ++++LTEIKVMKQ +HPN+VNYIES+L+ D +LWVV++YL+GG LTDVV +T +D G IA+V++ECL AL FLH ++I+HRDIKSDNVLLG +G+VK+TD GFCAQ+ S+R T+VGTPYWM+PE++N+ QY+ K+DIWSLGIM +EM+DGEPPY+ ETPLKAIY I G+P K ++ + +FL CL +DP+ R LL H FLK+ K L ++ I A
Sbjct: 354 REKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDAD-DLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPEILNKK-QYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRA 645
BLAST of SMED30035597 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 327.405 bits (838), Expect = 1.972e-104 Identity = 159/295 (53.90%), Postives = 215/295 (72.88%), Query Frame = -2
Query: 207 KNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDA 1085
+ K+SD+E L EIV NPL KYE+ +++G GASGTV +A + + VA+K M QP ++++LTEIKVMKQ +HPN+VNYIES+L+ D +LWVV++YL+GG LTDVV +T +D G IA+V++ECL AL FLH ++I+HRDIKSDNVLLG +G+VK+TD GFCAQ+ S+R T+VGTPYWM+PE++N+ QY+ K+DIWSLGIM +EM+DGEPPY+ ETPLKAIY I G+P K ++ + +FL CL +DP+ R LL H FLK+ K L ++ I A
Sbjct: 351 REKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDAD-DLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPEILNKK-QYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRA 642
BLAST of SMED30035597 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334539) HSP 1 Score: 340.502 bits (872), Expect = 1.065e-108 Identity = 170/297 (57.24%), Postives = 212/297 (71.38%), Query Frame = -2
Query: 204 KKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP--SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1088
KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ +HPN+VNY++S+L+ E ELWVV+EYL GG+LTDVVTET MD G IA+V +E L ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R QY K+D+WSLGIM IEM++GEPPY++E PLKA+Y I T G+P K K+ + FL CLE++ + R SA LLKH FLK + L ++ I AA
Sbjct: 404 KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE--ELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRK-QYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAA 697 HSP 2 Score: 53.1434 bits (126), Expect = 4.769e-7 Identity = 22/54 (40.74%), Postives = 35/54 (64.81%), Query Frame = -2
Query: 1284 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAV 1445
IS PTN + VHV FD T +F G+P+ W +LL ++ SK+E+ K+P + + +
Sbjct: 83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVL 136
BLAST of SMED30035597 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081714) HSP 1 Score: 340.502 bits (872), Expect = 1.065e-108 Identity = 170/297 (57.24%), Postives = 212/297 (71.38%), Query Frame = -2
Query: 204 KKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP--SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1088
KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ +HPN+VNY++S+L+ E ELWVV+EYL GG+LTDVVTET MD G IA+V +E L ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R QY K+D+WSLGIM IEM++GEPPY++E PLKA+Y I T G+P K K+ + FL CLE++ + R SA LLKH FLK + L ++ I AA
Sbjct: 404 KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE--ELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRK-QYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAA 697 HSP 2 Score: 53.1434 bits (126), Expect = 4.769e-7 Identity = 22/54 (40.74%), Postives = 35/54 (64.81%), Query Frame = -2
Query: 1284 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAV 1445
IS PTN + VHV FD T +F G+P+ W +LL ++ SK+E+ K+P + + +
Sbjct: 83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVL 136
BLAST of SMED30035597 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081716) HSP 1 Score: 340.502 bits (872), Expect = 1.065e-108 Identity = 170/297 (57.24%), Postives = 212/297 (71.38%), Query Frame = -2
Query: 204 KKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP--SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1088
KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ +HPN+VNY++S+L+ E ELWVV+EYL GG+LTDVVTET MD G IA+V +E L ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R QY K+D+WSLGIM IEM++GEPPY++E PLKA+Y I T G+P K K+ + FL CLE++ + R SA LLKH FLK + L ++ I AA
Sbjct: 404 KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE--ELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRK-QYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAA 697 HSP 2 Score: 53.1434 bits (126), Expect = 4.769e-7 Identity = 22/54 (40.74%), Postives = 35/54 (64.81%), Query Frame = -2
Query: 1284 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAV 1445
IS PTN + VHV FD T +F G+P+ W +LL ++ SK+E+ K+P + + +
Sbjct: 83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVL 136
BLAST of SMED30035597 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081715) HSP 1 Score: 340.502 bits (872), Expect = 1.065e-108 Identity = 170/297 (57.24%), Postives = 212/297 (71.38%), Query Frame = -2
Query: 204 KKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP--SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1088
KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ +HPN+VNY++S+L+ E ELWVV+EYL GG+LTDVVTET MD G IA+V +E L ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R QY K+D+WSLGIM IEM++GEPPY++E PLKA+Y I T G+P K K+ + FL CLE++ + R SA LLKH FLK + L ++ I AA
Sbjct: 404 KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE--ELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRK-QYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAA 697 HSP 2 Score: 53.1434 bits (126), Expect = 4.769e-7 Identity = 22/54 (40.74%), Postives = 35/54 (64.81%), Query Frame = -2
Query: 1284 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAV 1445
IS PTN + VHV FD T +F G+P+ W +LL ++ SK+E+ K+P + + +
Sbjct: 83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVL 136
BLAST of SMED30035597 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334544) HSP 1 Score: 340.502 bits (872), Expect = 1.065e-108 Identity = 170/297 (57.24%), Postives = 212/297 (71.38%), Query Frame = -2
Query: 204 KKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP--SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1088
KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ +HPN+VNY++S+L+ E ELWVV+EYL GG+LTDVVTET MD G IA+V +E L ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R QY K+D+WSLGIM IEM++GEPPY++E PLKA+Y I T G+P K K+ + FL CLE++ + R SA LLKH FLK + L ++ I AA
Sbjct: 404 KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE--ELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRK-QYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAA 697 HSP 2 Score: 53.1434 bits (126), Expect = 4.769e-7 Identity = 22/54 (40.74%), Postives = 35/54 (64.81%), Query Frame = -2
Query: 1284 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAV 1445
IS PTN + VHV FD T +F G+P+ W +LL ++ SK+E+ K+P + + +
Sbjct: 83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVL 136
BLAST of SMED30035597 vs. Ensembl Zebrafish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2]) HSP 1 Score: 365.155 bits (936), Expect = 2.032e-120 Identity = 201/453 (44.37%), Postives = 270/453 (59.60%), Query Frame = -2
Query: 204 KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEK-------------------------------TPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1463
KE P EISNP++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L ++ DKD + + PV + P I +T+ K + K+ K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 70 KERP-EISNPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNSRQKYL----SFTDKDAPQAKKGSEQSPVKDPDDDDEDAPPPVVAPRPQHTISVYTRSVIDPIPAPAAIADTDGSKAADKQ-----KKGKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 509
BLAST of SMED30035597 vs. Ensembl Zebrafish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2]) HSP 1 Score: 365.155 bits (936), Expect = 2.032e-120 Identity = 201/453 (44.37%), Postives = 270/453 (59.60%), Query Frame = -2
Query: 204 KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEK-------------------------------TPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1463
KE P EISNP++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L ++ DKD + + PV + P I +T+ K + K+ K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 70 KERP-EISNPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNSRQKYL----SFTDKDAPQAKKGSEQSPVKDPDDDDEDAPPPVVAPRPQHTISVYTRSVIDPIPAPAAIADTDGSKAADKQ-----KKGKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 509
BLAST of SMED30035597 vs. Ensembl Zebrafish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2]) HSP 1 Score: 365.155 bits (936), Expect = 2.032e-120 Identity = 201/453 (44.37%), Postives = 270/453 (59.60%), Query Frame = -2
Query: 204 KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEK-------------------------------TPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1463
KE P EISNP++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L ++ DKD + + PV + P I +T+ K + K+ K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 70 KERP-EISNPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNSRQKYL----SFTDKDAPQAKKGSEQSPVKDPDDDDEDAPPPVVAPRPQHTISVYTRSVIDPIPAPAAIADTDGSKAADKQ-----KKGKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 509
BLAST of SMED30035597 vs. Ensembl Zebrafish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2]) HSP 1 Score: 362.459 bits (929), Expect = 2.249e-119 Identity = 201/453 (44.37%), Postives = 268/453 (59.16%), Query Frame = -2
Query: 204 KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEK-------------------------------TPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1463
KE P EISNP++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L DKD + + PV + P I +T+ K + K+ K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 70 KERP-EISNPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNSRQKYLSFTA---DKDAPQAKKGSEQSPVKDPDDDDEDAPPPVVAPRPQHTISVYTRSVIDPIPAPAAIADTDGSKAADKQ-----KKGKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 510
BLAST of SMED30035597 vs. Ensembl Zebrafish
Match: pak2b (p21 protein (Cdc42/Rac)-activated kinase 2b [Source:ZFIN;Acc:ZDB-GENE-030131-3759]) HSP 1 Score: 361.688 bits (927), Expect = 7.959e-119 Identity = 211/480 (43.96%), Postives = 283/480 (58.96%), Query Frame = -2
Query: 204 FFKNLKSGANKKE---EPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGE--PRDNGLKPVAEEK------------------TPPEIV--ETENQKKLETNTST------PV---------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP---SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1496
F + G +K+ E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L + + +D +GE P +P + K TPP +V E+ K + T S PV + KK KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ E EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P SP+ K+ FL CLE+D R ++ LL+H FLK K L ++ I AA
Sbjct: 55 IFSGAEKGGRRKDRDKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGRQKYL-SFSSEKDSFPSGEQSPAKKTPEPSSPVKAVDDEDNGEDEDDDDDEETPPPVVAPRPEHTKSVYTRPSVIDPLPPPVTSPESDAASKATDRQRPKKGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGE--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQSPE-KLSPIFRDFLGRCLEMDVEKRGGSKELLQHPFLKLAKPLSSLTPLILAA 529
BLAST of SMED30035597 vs. Ensembl Xenopus
Match: taf3 (TATA-box binding protein associated factor 3 [Source:Xenbase;Acc:XB-GENE-940280]) HSP 1 Score: 368.622 bits (945), Expect = 1.306e-121 Identity = 210/470 (44.68%), Postives = 284/470 (60.43%), Query Frame = -2
Query: 204 MLKFFKNLKSGANKKE-EPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKH---EKFLGNKENYEDKDETG---EPRDNGLKPVAEE--------KTPPEIV--ETENQKKLETNT-----------------STPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
++ F + G+ KKE E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F Y+ KH +K+L +D +G P G +P K PP ++ E+ K + T + + ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ LE+D R SA LL+H FLK K L ++ I AA
Sbjct: 47 IISMFSGTEKGSRKKERERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKF---YDSKHTDKQKYLSFSAPDKDGLPSGVSSAPNAKGSEPSTAATDDDSDDDKAPPPVIAPRPEHTKSMYTRSVIDPIPPPPGDSDSAAKAGDRQKKKTKMSDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVSD--ELYVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQKPEKLSPIFRDFLNRSLEMDVEKRGSARELLQHPFLKLAKPLSSLTPLILAA 510
BLAST of SMED30035597 vs. Ensembl Xenopus
Match: qsox2 (quiescin sulfhydryl oxidase 2 [Source:Xenbase;Acc:XB-GENE-986398]) HSP 1 Score: 365.54 bits (937), Expect = 2.243e-120 Identity = 202/456 (44.30%), Postives = 269/456 (58.99%), Query Frame = -2
Query: 213 KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMK-DYEEKHEKFLGNKENYEDK-------DETGEPRDNGLKPVAEEKTPP---------------EIVE-----------TENQKKLETNTSTPV--KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPS---PKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASI 1463
K P IS+P + HV DP T +F G+P W +LL A+ SK ++ K+P + + + F + K +K++ +N + D P + PV E + PP ++E TEN + + V +KK KM+D E L IV+ +P KY E++G GASGTV +A TG +VAIK MNL +QP ++LI+ EI VM++ +HPNIVNY++S+L+ E ELWVV+EYL GG+LTDVVTET M G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ ++R TMVGTPYWMAPEVV R Y K+D+WSLGIM IEM++GEPPY++E PL+A+Y I T G P P+ K FL CLE+D R SA LL+H FLK K + ++ I
Sbjct: 59 KNPPLVISSPFGYEHIYHVGIDPSTGEFTGMPKQWAQLLQTANISKIDQKKNPQVVLDVLNFYSSETTSKSQKYMSFTDNSREAYNSNSVLDAKPVPEVAEVLPVPEAEDPPAFPPRPDHTKSIYTRSVIEPPVPPLAAKPTTENGSSVTDGAESSVDKTKKKPKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYIAVDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHPNIVNYLDSYLVGE--ELWVVMEYLAGGSLTDVVTETCMQEGEIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGAVKLTDFGFCAQISPEQNKRSTMVGTPYWMAPEVVTRKA-YGPKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPQLQEPEKKSPA-FRDFLSRCLEMDVEKRGSARDLLQHPFLKVAKPMSSLTPYI 510
BLAST of SMED30035597 vs. Ensembl Xenopus
Match: qsox2 (quiescin sulfhydryl oxidase 2 [Source:Xenbase;Acc:XB-GENE-986398]) HSP 1 Score: 351.673 bits (901), Expect = 4.130e-116 Identity = 192/412 (46.60%), Postives = 254/412 (61.65%), Query Frame = -2
Query: 213 VHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKD----YEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVE--TENQKKLETNTSTPV--KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPS---PKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASI 1415
V T E G+P W +LL A+ SK ++ K+P + + + F +K+ F G + + K+ G+ + V E PP + TEN + + V +KK KM+D E L IV+ +P KY E++G GASGTV +A TG +VAIK MNL +QP ++LI+ EI VM++ +HPNIVNY++S+L+ E ELWVV+EYL GG+LTDVVTET M G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ ++R TMVGTPYWMAPEVV R Y K+D+WSLGIM IEM++GEPPY++E PL+A+Y I T G P P+ K FL CLE+D R SA LL+H FLK K + ++ I
Sbjct: 25 VLSTIQQEQPPKFGMPKQWAQLLQTANISKIDQKKNPQVVLDVLNFYSSETTSKSQKYMSFTGKRFWQKPKEALGQIYT---RSVIEPPVPPLAAKPTTENGSSVTDGAESSVDKTKKKPKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYIAVDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHPNIVNYLDSYLVGE--ELWVVMEYLAGGSLTDVVTETCMQEGEIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGAVKLTDFGFCAQISPEQNKRSTMVGTPYWMAPEVVTRKA-YGPKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPQLQEPEKKSPA-FRDFLSRCLEMDVEKRGSARDLLQHPFLKVAKPMSSLTPYI 429
BLAST of SMED30035597 vs. Ensembl Xenopus
Match: flii (FLII actin remodeling protein [Source:Xenbase;Acc:XB-GENE-478681]) HSP 1 Score: 341.273 bits (874), Expect = 5.118e-111 Identity = 192/451 (42.57%), Postives = 262/451 (58.09%), Query Frame = -2
Query: 204 KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYED-----------------------KDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1481
K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F E L N + + PR K + + T K+ T+ TP N S + Y D K D+ E+ E+L S TV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL+FLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + ++ FL+ CLE+D + R SA+ LL+H FLK K L ++ I AA
Sbjct: 58 KTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETFLSHVLQNAKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVIEPVALTAPAKEASTSPVTPQPENSNS-STSTLYRNTDRQRKKSKMTDE-EILEKLRTFLSRTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAIFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 503
BLAST of SMED30035597 vs. Ensembl Xenopus
Match: flii (FLII actin remodeling protein [Source:Xenbase;Acc:XB-GENE-478681]) HSP 1 Score: 340.117 bits (871), Expect = 7.089e-111 Identity = 176/330 (53.33%), Postives = 227/330 (68.79%), Query Frame = -2
Query: 204 PVAEEKTPPEIVETENQKKLETNT---STPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1178
P E T P + EN T+T +T +RKK+KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL+FLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + ++ FL+ CLE+D + R SA+ LL+H FLK K L ++ I AA
Sbjct: 163 PAKEASTSPVTPQPENSNS-STSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAIFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 488 HSP 2 Score: 52.373 bits (124), Expect = 1.340e-6 Identity = 25/67 (37.31%), Postives = 42/67 (62.69%), Query Frame = -2
Query: 1278 ANKKEEP--FEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIF 1472
ANKK+E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F
Sbjct: 7 ANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKF 73
BLAST of SMED30035597 vs. Ensembl Mouse
Match: Pak1 (p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975]) HSP 1 Score: 368.237 bits (944), Expect = 2.617e-121 Identity = 210/487 (43.12%), Postives = 285/487 (58.52%), Query Frame = -2
Query: 204 KFFKNL----KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKH-EKFLG------------NKENYEDKDETGE---------------------PRDNGLKPVAEEK-------TPPEIVETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++++ K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F + + +K++ N N + ET PR K V TP V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 53 RFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDEDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA 536
BLAST of SMED30035597 vs. Ensembl Mouse
Match: Pak1 (p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975]) HSP 1 Score: 368.237 bits (944), Expect = 2.617e-121 Identity = 210/487 (43.12%), Postives = 285/487 (58.52%), Query Frame = -2
Query: 204 KFFKNL----KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKH-EKFLG------------NKENYEDKDETGE---------------------PRDNGLKPVAEEK-------TPPEIVETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++++ K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F + + +K++ N N + ET PR K V TP V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 53 RFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDEDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA 536
BLAST of SMED30035597 vs. Ensembl Mouse
Match: Pak2 (p21 (RAC1) activated kinase 2 [Source:MGI Symbol;Acc:MGI:1339984]) HSP 1 Score: 357.451 bits (916), Expect = 2.172e-117 Identity = 204/448 (45.54%), Postives = 275/448 (61.38%), Query Frame = -2
Query: 204 EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDN--GLKPVA---------EEKTPPEIV-ETENQKKLETNT-----STPV--------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1448
EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F D +K+L +D +G P N G + A E+ PP I ++ K + T + PV ++KK KM+D E L IV+ +P KY E++G GASGTV AT G +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++S+L+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 73 EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY-DSNTVKQKYLSFTPPEKDGFPSGTPALNTKGSETSAVVTEEDDDDEDAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAA 516
BLAST of SMED30035597 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656]) HSP 1 Score: 340.502 bits (872), Expect = 1.794e-110 Identity = 175/324 (54.01%), Postives = 224/324 (69.14%), Query Frame = -2
Query: 204 EEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1169
+E PP E N L NT +RKK+KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL+FLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + ++ FL+ CLE+D + R SA+ LL+H FLK K L ++ I AA
Sbjct: 218 KEDIPPS-AENANSTTLYRNTDR--QRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 535 HSP 2 Score: 52.373 bits (124), Expect = 1.035e-6 Identity = 23/68 (33.82%), Postives = 42/68 (61.76%), Query Frame = -2
Query: 1278 KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIF 1481
K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F
Sbjct: 58 KTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKF 125
BLAST of SMED30035597 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656]) HSP 1 Score: 340.502 bits (872), Expect = 1.794e-110 Identity = 175/324 (54.01%), Postives = 224/324 (69.14%), Query Frame = -2
Query: 204 EEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1169
+E PP E N L NT +RKK+KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL+FLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + ++ FL+ CLE+D + R SA+ LL+H FLK K L ++ I AA
Sbjct: 218 KEDIPPS-AENANSTTLYRNTDR--QRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 535 HSP 2 Score: 52.373 bits (124), Expect = 1.035e-6 Identity = 23/68 (33.82%), Postives = 42/68 (61.76%), Query Frame = -2
Query: 1278 KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIF 1481
K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F
Sbjct: 58 KTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKF 125
BLAST of SMED30035597 vs. UniProt/SwissProt
Match: sp|P35465|PAK1_RAT (Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus OX=10116 GN=Pak1 PE=1 SV=3) HSP 1 Score: 369.007 bits (946), Expect = 1.045e-120 Identity = 212/487 (43.53%), Postives = 286/487 (58.73%), Query Frame = -2
Query: 204 KFFKNLKSG--ANKKEEP--FEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKH-EKFLG------------NKENYEDKDETGE---------------------PRDNGLKPVAEEK-------TPPEIVETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++++ +G NKK+E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F + + +K++ N N + ET PR K V TP V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 53 RFYRSILAGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDEDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA 536
BLAST of SMED30035597 vs. UniProt/SwissProt
Match: sp|Q13153|PAK1_HUMAN (Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2) HSP 1 Score: 368.237 bits (944), Expect = 2.124e-120 Identity = 212/492 (43.09%), Postives = 287/492 (58.33%), Query Frame = -2
Query: 204 KFFKNL----KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGL--KPVAE----------------EKTPPEI---------------------------VETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP---SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++++ K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F Y K ++ DK N L K V+E + TPP + V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P +P+ K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 53 RFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEF---YNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE-KLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA 537
BLAST of SMED30035597 vs. UniProt/SwissProt
Match: sp|Q08E52|PAK1_BOVIN (Serine/threonine-protein kinase PAK 1 OS=Bos taurus OX=9913 GN=PAK1 PE=1 SV=1) HSP 1 Score: 367.466 bits (942), Expect = 4.882e-120 Identity = 211/488 (43.24%), Postives = 286/488 (58.61%), Query Frame = -2
Query: 204 KFFKNL----KSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKH-EKFLG------------NKENYEDKDETGE---------------------PRDNGLKPVAEEK-------TPPEIVETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP---SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++ + K+ K++E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F + + +K++ N N + ET PR K V TP V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P +P+ K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 53 RFYRAILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKAVSETPAVPPVSEDEDDDDDGTPPPVIAPRPEHTKSVYTRSVIEPLPITPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE-KLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA 536
BLAST of SMED30035597 vs. UniProt/SwissProt
Match: sp|O88643|PAK1_MOUSE (Serine/threonine-protein kinase PAK 1 OS=Mus musculus OX=10090 GN=Pak1 PE=1 SV=1) HSP 1 Score: 365.155 bits (936), Expect = 3.011e-119 Identity = 211/488 (43.24%), Postives = 280/488 (57.38%), Query Frame = -2
Query: 204 KFFKNLKSG--ANKKEEP--FEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFL-------------GNKENYEDKDETGE----------------------PRDNGLKPVAEEK-------TPPEIVETENQKKLETNTSTP--------VKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+F++++ G NKK E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F + + K N N + ET PR K V TP V T E NT+ P ++KK KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ ++PNIVNY++S+L+ + ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL CLE+D R SA+ LL+H FLK K L ++ + AA
Sbjct: 53 RFYRSILPGDKTNKKREKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSKKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDDEDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTPFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLQCCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLMHAA 537
BLAST of SMED30035597 vs. UniProt/SwissProt
Match: sp|Q13177|PAK2_HUMAN (Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3) HSP 1 Score: 358.992 bits (920), Expect = 5.006e-117 Identity = 202/448 (45.09%), Postives = 271/448 (60.49%), Query Frame = -2
Query: 204 EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEE-----------KTPPEIV-ETENQKKLETNT-----STPV--------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1448
EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F D +K+L +D +G P N A PP I ++ K + T + PV ++KK KM+D E L IV+ +P KY E++G GASGTV AT G +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++S+L+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 73 EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY-DSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAA 516
BLAST of SMED30035597 vs. TrEMBL
Match: A0A0X3PTP0 (Serine/threonine-protein kinase PAK 3 OS=Schistocephalus solidus OX=70667 GN=PAK3 PE=4 SV=1) HSP 1 Score: 485.337 bits (1248), Expect = 3.588e-164 Identity = 266/508 (52.36%), Postives = 337/508 (66.34%), Query Frame = -2
Query: 204 MLKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYE-----EKHEKFL---------GNKENYEDKD----ETGEPRDNGLKPVAEEKTPPE------------------------IVETENQKKLETNTS----------------TPV---------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAK-VDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
M+K F++L+ K EIS PTNV+K +HVT+DP T +F G+PDYWK+L++ A+FS+EEKT HP EI NAV K YE +K +KFL G ++ +E K+ E G+P +E PPE +V T + +L +TS PV +R K KM+D EF+ AL++I+T +P +KY ++E+LG+GASGTVRLA + +T VAIKIMNL KQPNRDLI++EI+VM+ T+H NIVNYIESFL+ + ELWVV+E+LDGG LTDVVTETIM+ LIA+VVKE L AL FLH+ NIIHRDIKSDN+LLGKSG+VK+TDFGFCAQLGSR S+RQT+VG+PYWMAPEVVN++VQY KIDIWSLGIMIIEMLDGEPPY++ETPLKAIY IQT RP PK + VD L+ FL CL+++P R +A LL+H FLK KSL + A I+AA
Sbjct: 1 MMKPFRHLRQRWTDKTI-TEISMPTNVEKMIHVTYDPVTGEFCGMPDYWKELINGANFSQEEKTNHPKEIINAV---KTYEVTLKNQKSDKFLGVSVGSIPDGEEDEHERKNASTSENGKPEHESTG--SESSIPPEAPRPTLLEVAGNSPRSTKTGRALPVVHTNPKNQLPKSTSDKDIASESNPPDAFKKQPVPNTNTELKVQAPAVRRRAKKKMTDAEFFEALEKIITTGDPHEKYVMDEKLGSGASGTVRLARSVQTNEPVAIKIMNLSKQPNRDLIISEIQVMEHTRHENIVNYIESFLLRDKNELWVVMEFLDGGPLTDVVTETIMETPLIAAVVKEVLKALAFLHQANIIHRDIKSDNILLGKSGRVKLTDFGFCAQLGSRLSKRQTIVGSPYWMAPEVVNKSVQYGPKIDIWSLGIMIIEMLDGEPPYLNETPLKAIYLIQTHDRPEPKTEGVDPSLKDFLDRCLQVNPEKRAAAAELLEHPFLKNTKSLAGLQALIEAA 502
BLAST of SMED30035597 vs. TrEMBL
Match: A0A5K3EIT4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 469.159 bits (1206), Expect = 5.877e-158 Identity = 255/498 (51.20%), Postives = 319/498 (64.06%), Query Frame = -2
Query: 204 LKFFKNLKSGANKKEEPF-EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVI----FMKDYEEKHEKFLGNKENYEDKD------------ETGEPRDNG-----------------LKPV-----------AEEKTPPEIVETENQKK-------LETNTSTPV------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA-KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1502
+K F + N+K+ EIS PT+V+K +HV FDP T F+G+P YW++L+ QA+FS EE+ HP EI NA F+K E + + + + +D D E G+P + L V +E +P E + QKK L+ PV +R K KM+D EF+ AL +I++ NPLDKY L LG+GASGTVR A K T VAIKIMNL KQPNRDLI++EI+VM+ T+H NIVNY+ES+L+ +D ELWVV+EYLDGG LTDVVTET+M+ LIA+VVKECL A+ FLHE NIIHRDIKSDN+LLGKSG+VK+TDFGFCAQ+GSR S+RQTMVGTPYWMAPEVVN+ V+Y KIDIWSLGIMIIEMLDGEPPY++E PLKAIY IQT RP PK+ +V + FL CL++DP R SA LL H FLK+ K L + A I+AA
Sbjct: 1 MKPFSRFRQRWNEKQGNISEISMPTSVEKLIHVEFDPATGKFMGMPAYWQELISQANFSDEEQRNHPAEIINACQTHDNFIKQQEHNEKFLVASGSSLDDLDESDRKLSDLSGTENGKPGHSSTGSESSNVPDASSPQSLLAKVMTGSNFQKNQQSETSSPAEPTSGDTQKKTYKPLPVLKQPAEAPVVQNEKAKDAYVRRRNKKKMTDEEFFDALSKIISSGNPLDKYCLESVLGSGASGTVRRAHNKITNEPVAIKIMNLAKQPNRDLIISEIQVMEHTRHENIVNYVESYLLRDDGELWVVMEYLDGGPLTDVVTETVMETPLIAAVVKECLKAIHFLHEKNIIHRDIKSDNILLGKSGRVKLTDFGFCAQMGSRHSKRQTMVGTPYWMAPEVVNKAVKYGPKIDIWSLGIMIIEMLDGEPPYLNEPPLKAIYLIQTHERPEPKSTEVSPLMRDFLDKCLQVDPEKRASAAELLLHPFLKETKPLAGLCALIEAA 498
BLAST of SMED30035597 vs. TrEMBL
Match: A0A564YIV2 (Protein kinase domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6262 PE=3 SV=1) HSP 1 Score: 468.389 bits (1204), Expect = 9.790e-158 Identity = 260/486 (53.50%), Postives = 326/486 (67.08%), Query Frame = -2
Query: 204 MLKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVI----FMKDYEEKHEKFLG-NKENYEDKDE------TGEPRDNG--------------LKPVAEEKTPPEIVETE-NQKKLETNTST-----PV--------------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA-KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
M F + + ++K+ EIS PTNV K +HV FDP+T F GLP+ W++L+ QA+F+ EE+ H EI +A FMK +E +EKFLG + + +D DE TG +NG PV+ + +++ TE N+ K N ++ PV +R K KM+D EF+ AL I++ +PLDKY L LG+GASGTVR A KET VAIKIMNL KQPNRDLI++EI+VM+ T+H NIVNYIESFL+ ++ ELWVV+EYLDGG LTDVVTET+M+ LIA+VVKECL A+ FLHE NIIHRDIKSDN+LLGKSG+VK+TDFGFCAQ+GSR S+RQTMVGTPYWMAPEVVN+ V+Y KIDIWSLGIMIIEMLDGEPPY++E PLKAIY+IQT+ RP PK+ +V + FL CL+IDP R SA LLKH FL K L + A I+AA
Sbjct: 1 MKPFSRIRQRWSDKQSNISEISLPTNVAKLIHVEFDPKTKTFKGLPETWQELIAQANFTTEEQISHQAEIISACQTHDKFMKQ-QEHNEKFLGVSGSSLDDLDESNRKLSTGSGLENGNVDHNSTGSESSSLQDPVSPQSLLAKLMNTEINKDKHSDNFNSNKHAKPVPLVKPPIPPTPATEKTAQVRRRIKKKMTDFEFFDALAYIISTGDPLDKYCLESVLGSGASGTVRRAHNKETKEPVAIKIMNLSKQPNRDLIISEIQVMEHTRHENIVNYIESFLLKDEDELWVVMEYLDGGPLTDVVTETVMEGPLIAAVVKECLKAIHFLHEKNIIHRDIKSDNILLGKSGRVKLTDFGFCAQMGSRQSKRQTMVGTPYWMAPEVVNKAVKYGPKIDIWSLGIMIIEMLDGEPPYLNEPPLKAIYHIQTQERPEPKSTEVSPLMRDFLDRCLQIDPEKRASAAELLKHPFLLDTKPLSGLCALIEAA 485
BLAST of SMED30035597 vs. TrEMBL
Match: A0A158R6P8 (Protein kinase domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS646 PE=3 SV=1) HSP 1 Score: 465.692 bits (1197), Expect = 1.170e-156 Identity = 256/492 (52.03%), Postives = 313/492 (63.62%), Query Frame = -2
Query: 204 LKFFKNLKSGANKKEEPF-EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVI----FMKDYEE-------------------------------KHE----------------------KFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA-KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1502
+K F ++ N+K+ EIS PT+V+K +HV FDP T F G+PD W++L+ QA+F+ EE+ H EI +A F+K E KHE + + N + + K G LKP A K PP T +K P++RK +M+D EFY AL +IV+ +PLDKY L LG+GASGTVR AT K T VAIKIMNL KQPNRDLI++EI+VM+ T+H NIVNYIESFL+ + ELWVV+EYLDGG LTDVVTETIM+ LIA+VVKECL A+ FLHE NIIHRDIKSDN+LLGKSG+VK+TDFGFCAQLGSR S+RQTMVGTPYWMAPEVVN++V+Y KIDIWSLGIMIIEMLDGEPPY++E PLKAIY IQT+ RP PK+ +V L FL CL++DP R +A LLKH FL K L + A I AA
Sbjct: 1 MKPFSRIRQRWNEKQCNISEISMPTSVEKLLHVEFDPVTKKFKGMPDAWQELISQANFTDEERICHHKEIIDACQVHDNFIKQQEHNEKFIRVSGSSLDDLDDSDRKLSDGSGIENGKHEHNSTGSESSNNPDHSSSQVLLSRLMMNSDRSKSKAVEGHAPAKPLKPSASLK-PPLAQPTPPEK----CKDAPLRRKTKRMNDAEFYEALSKIVSPGDPLDKYTLEAVLGSGASGTVRRATRKATNEPVAIKIMNLSKQPNRDLIISEIQVMEHTRHENIVNYIESFLMRNEDELWVVMEYLDGGPLTDVVTETIMEQPLIAAVVKECLKAINFLHEKNIIHRDIKSDNILLGKSGRVKLTDFGFCAQLGSRQSKRQTMVGTPYWMAPEVVNKSVKYGPKIDIWSLGIMIIEMLDGEPPYLNEPPLKAIYLIQTRERPEPKSTEVGPMLRDFLDRCLQVDPEQRATAAELLKHPFLSDTKPLSGLGALIKAA 487
BLAST of SMED30035597 vs. TrEMBL
Match: A0A0R3X8P4 (Protein kinase domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS9904 PE=3 SV=1) HSP 1 Score: 464.922 bits (1195), Expect = 2.060e-156 Identity = 248/469 (52.88%), Postives = 305/469 (65.03%), Query Frame = -2
Query: 204 EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVI----FMKDYEEKHEKFLGN--------------------------KENYEDKDETGEPR----------------------DNGLKPVAEEKTPPEIVETENQKKL-ETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA-KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1448
EIS PT+V+K +HV +DP T F G+P+ W++L+ Q++F+ EE+ HP EI NA F+K +E +EKFLG + N D + P +GL P K I + Q + E P++RK KM+D EFY AL +I++ +PLDKY L LG+GASGTVR A K T VAIKIMNL KQPNRDLI++EI+VM+ T+H NIVNYIESFL+ + ELWVV+EYLDGG LTDVVTETIM+ LIA+VVKECL A+ FLHE NIIHRDIKSDN+LLGKSG VK+TDFGFCAQ+GSR S+RQTMVGTPYWMAPEVVN++V+Y KIDIWSLGIMIIEMLDGEPPY++E PLKAIY IQT+ RP PK+ +V L FL CL++DP R +A LL H FL K L ++A I AA
Sbjct: 20 EISMPTSVEKLLHVEYDPVTKKFKGMPEAWQELISQSNFTDEEQICHPEEIINACQTHDKFIKQ-QEHNEKFLGVSGSSLDDLDDSDRKLSDGSGIENGKLEHNSTGSDSSNNPDATSAQTLLAKVMMNSERNKPKVADGLAPTNPLKPSSSIKPSVAQTAVPEKAKDAPLRRKAKKMTDPEFYEALSKIISPGDPLDKYSLETVLGSGASGTVRRARCKATNEPVAIKIMNLSKQPNRDLIISEIQVMEHTRHENIVNYIESFLMRNEDELWVVMEYLDGGPLTDVVTETIMETPLIAAVVKECLKAINFLHEKNIIHRDIKSDNILLGKSGHVKLTDFGFCAQMGSRQSKRQTMVGTPYWMAPEVVNKSVKYGPKIDIWSLGIMIIEMLDGEPPYLNEPPLKAIYLIQTRERPEPKSTEVSPLLRDFLDKCLQVDPEKRATAAELLNHPFLSDTKPLSGLSALIKAA 487
BLAST of SMED30035597 vs. Ensembl Cavefish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2]) HSP 1 Score: 365.155 bits (936), Expect = 3.130e-119 Identity = 206/449 (45.88%), Postives = 274/449 (61.02%), Query Frame = -2
Query: 204 EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKD-----ETGEPRDNGLK---PVAEEKTPPEIV--ETENQKKLETNTST----PV-----------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP---SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1448
EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L ++ DKD + EP G K ++ PP IV E+ K + T S P+ K K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ E EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P +P+ K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 164 EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGKQKYL----SFTDKDAPPAMKGSEPSPGGAKEFDDQDDDDAPPPIVAPRPEHTKSVLTRPSMIDPLPLPAASADSDASRAADRQKKNPKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGE--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE-KLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 604
BLAST of SMED30035597 vs. Ensembl Cavefish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29]) HSP 1 Score: 351.288 bits (900), Expect = 4.438e-115 Identity = 208/479 (43.42%), Postives = 278/479 (58.04%), Query Frame = -2
Query: 204 KFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYE----EKHEKFLGNKENYEDKDET---GEPRDNGLKPVAE--------------EKTPPEIV--ETENQKKLETN--------------TSTPV--------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1499
+ +++ +GANKK+E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F E +K+ F G EN+ + P N K V+E E PP ++ E+ K + T+ T TP K +K KMSD E L IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ + P +V ELWVV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 52 RSIRSILTGANKKKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETANSQKYMSFTG--ENFTPHFLSVFFPRPLQNS-KTVSETPAVATVSEDEDENEAAPPPVIAPRPEHTKSVSTSYIYISLTHINGGSPTPTPSSTAPRSADKTRKKKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENK-PYLVG----------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSSVFRDFLNRCLEMDVEKRGSAKELLQHQFLKVAKPLSSLTPLILAA 515
BLAST of SMED30035597 vs. Ensembl Cavefish
Match: pak2b (p21 protein (Cdc42/Rac)-activated kinase 2b [Source:ZFIN;Acc:ZDB-GENE-030131-3759]) HSP 1 Score: 344.739 bits (883), Expect = 6.703e-113 Identity = 190/405 (46.91%), Postives = 256/405 (63.21%), Query Frame = -2
Query: 204 GLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLG--NKENYEDKDET---------GEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP---SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1376
G+P+ W +LL ++ +K E+ K+P + + + F +K+L + E + +++ G R + V + PP + T+ + + + K KK KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ E EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P SP+ K+ FL CLE+D R S++ LL+H FLK K L ++ I AA
Sbjct: 84 GMPEQWARLLQTSNITKYEQKKNPQAVLDVLKFYDSTGNGRQKYLSFSSGELFVSREKVRETVYLSVGGNFRYANTRSVLDP-IPPPVCTTDGD--VASKAADKQKPKKGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGE--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQSPE-KLSPIFRDFLARCLEMDVEKRGSSKELLQHPFLKLAKPLSSLTPLILAA 481
BLAST of SMED30035597 vs. Ensembl Cavefish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29]) HSP 1 Score: 339.347 bits (869), Expect = 9.454e-111 Identity = 198/451 (43.90%), Postives = 262/451 (58.09%), Query Frame = -2
Query: 204 NKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYE----EKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIV--ETENQKKLET----------NTSTP---------VKRKKNKMSDNEFYAA--LDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1469
NKK+E EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F E +K+ F G EN+ D+DE E PP ++ E+ K + T N S P SD + + IV+ +P KY E++G GASGTV A TG +VAIK MNL +QP ++LI+ EI VM++ + P +V ELWVV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDN+LLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R SA+ LL+H FLK K L ++ I AA
Sbjct: 66 NKKKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETANSQKYMSFTG--ENFTDEDEN-------------EAAPPPVIAPRPEHTKSVSTSYIYISLTHINLSPPPCCPTCISYSLILLLLFSDCLCVSCVFIGSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENK-PYLVG----------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSSVFRDFLNRCLEMDVEKRGSAKELLQHQFLKVAKPLSSLTPLILAA 489
BLAST of SMED30035597 vs. Ensembl Cavefish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2]) HSP 1 Score: 322.013 bits (824), Expect = 5.143e-104 Identity = 203/495 (41.01%), Postives = 271/495 (54.75%), Query Frame = -2
Query: 204 LFSLLNYFGSYFFMLKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKD-----ETGEPRDNGLK---PVAEEKTPPEIV--ETENQKKLETNTST----PV-----------------KRKKNKMSDNEFYAALDEIV---TKENPLDKYELNE------------RLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1544
LF L + L F K +K E P EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F +K+L ++ DKD + EP G K ++ PP IV E+ K + T S P+ K K KM+D E L IV T+ + E V + +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ E EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 3 LFKLTLLISTPSLSLSFLGGRKKDKDK-ERP-EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGKQKYL----SFTDKDAPPAMKGSEPSPGGAKEFDDQDDDDAPPPIVAPRPEHTKSVLTRPSMIDPLPLPAASADSDASRAADRQKKNPKGKMTDEEIMEKLRTIVKEHTESRCTCAMTIKEFVLCVCVWCVCVCGVCVCVCCVCVCVRVRVRVQVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGE--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 488
BLAST of SMED30035597 vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69]) HSP 1 Score: 267.314 bits (682), Expect = 1.212e-81 Identity = 130/291 (44.67%), Postives = 192/291 (65.98%), Query Frame = -2
Query: 225 RKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTI 1091
R+ ++S +F AAL ++V +P + E ++G G++G V LA + +G +VA+K M+L KQ R+L+ E+ +M++ H N+V+ S+L+ + ELWVV+E+L+GGALTD+VT T M+ IA+V L AL +LH +IHRDIKSD++LL G++K++DFGFCAQ+ +RR+++VGTPYWMAPEV++R + Y ++D+WSLGIM+IEM+DGEPPY +E PL+A+ I+ P K K L FL L DP LR +A LL+H FL+ I
Sbjct: 392 REPPRISHEQFRAALQQVVDPGDPSEYLENFIKIGEGSTGVVCLAVDRRSGRQVAVKKMHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLVAD--ELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGFCAQVSKEVTRRKSLVGTPYWMAPEVISR-LPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPLLRGFLDQMLVRDPALRATALELLQHPFLQNAGPPACI 679
BLAST of SMED30035597 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 184.496 bits (467), Expect = 6.798e-53 Identity = 98/263 (37.26%), Postives = 151/263 (57.41%), Query Frame = -2
Query: 246 NPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILT-EIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIK--SDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQ 1025
+P + + ER+G G+ G V T VAIKI++L + + + EI V+ Q P + +Y S+L + +LW+++EYL GG+ D++ ++ IA++++E L L++LH IHRDIK + NVLL + G VK+ DFG QL +R T VGTP+WMAPEV+ ++ YD K DIWSLGI IE+ GEPP + P++ ++ I P+ + + F+ CL DP R +A+ LLKH F+++
Sbjct: 21 DPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYL--KGTKLWIIMEYLGGGSALDLIKPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLEGNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQR 280
BLAST of SMED30035597 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865]) HSP 1 Score: 184.111 bits (466), Expect = 2.597e-50 Identity = 99/272 (36.40%), Postives = 157/272 (57.72%), Query Frame = -2
Query: 246 VTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDV--VTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEV--VNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEI----DPNLRKSAESLLKHDFLKQ 1037
+++ + +EL ERLG+G G V A +TG VAIKI+ L + +I EI +MK+ +H NIV Y S+L +LW+ +E+ GG+L D+ VT + + IA V +E L L +LH +HRDIK N+LL G VK+ DFG AQ+ + ++R++ +GTPYWMAPEV V R Y+ + D+W++GI IE+ + +PP D P++A++ + G PK + H+ +++ +P R +AE +L H +++Q
Sbjct: 5 ISRRTLQEDFELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYL--RHDKLWICMEHCGGGSLQDIYHVTGPLTERQ-IAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYVQQ 273
BLAST of SMED30035597 vs. Ensembl Sea Lamprey
Match: myo3a (myosin IIIA [Source:ZFIN;Acc:ZDB-GENE-041026-4]) HSP 1 Score: 174.481 bits (441), Expect = 9.106e-47 Identity = 101/282 (35.82%), Postives = 156/282 (55.32%), Query Frame = -2
Query: 246 ENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIM---NLLKQPNRDL---ILTEIKVMKQT-QHPNIVNYIESFLI---MEDKELWVVIEYLDGGALTDVVTETI-----MDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQ----YDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAK--VDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQ 1028
++P D +EL E +G G G V AT+++ G+K A+K + N L+ N+D+ I E ++ +HPNIV + + + +LW+V+E +GG++TD+V + MD LIA +++ L L LH +NIIHRDIK +N+LL G +++ DFG AQ+ R T VGTP+WMAPEV+ Q YD + D+WS+GI IE+ DG+PP + P++A++ I P+ K F+ CL D R + LL+ F++Q
Sbjct: 18 KDPSDTWELVETIGKGTYGKVYKATSRKDGSKAAVKTLDPVNNLETSNQDIDEEIEAEYSILTSLPEHPNIVRFFGMYYQKDGVNGDQLWIVLELCNGGSVTDLVKGQLKRGERMDVMLIAYILRGALLGLNHLHSHNIIHRDIKGNNILLTTDGGIRLVDFGVSAQVSKTRVERNTAVGTPFWMAPEVIACEQQLDYMYDRRCDVWSMGITAIELGDGDPPLYELHPMRALFKIPRNPPPTLKQPELWPPLFNEFIAQCLVKDFERRATVSQLLEDPFIQQ 299
BLAST of SMED30035597 vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66]) HSP 1 Score: 174.096 bits (440), Expect = 1.303e-46 Identity = 104/291 (35.74%), Postives = 154/291 (52.92%), Query Frame = -2
Query: 204 DEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGL----IASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVV----NRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1046
D + +P + + + LG GA G V A KE+G A K++ + + + EI+++ HPNIV + +F + +LW+ IE+ GGA+ ++ E ++ GL I V K+ L AL +LH + IIHRD+K+ N+LL G VK+ DFG A+ RR + +GTPYWMAPEVV + YD K DIWSLGI +IE+ EPP + P++ + I PS +K + FL CL+ +P R +A LL+H F+ S K + I A
Sbjct: 21 DHVRRDVDPAELWSVIGELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEILALCDHPNIVGLLNAFYY--ENKLWIFIEFCPGGAVDAIMLE--LERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFISGVDSNKPLRELIAEA 307
BLAST of SMED30035597 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 293.123 bits (749), Expect = 1.769e-89 Identity = 143/275 (52.00%), Postives = 192/275 (69.82%), Query Frame = -2
Query: 246 EFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQ 1064
+ YA L+EI + +P KY ++G GASG V A T VAIK MNL KQP ++LI+ EI VMK ++HPNIVN+I+S+++ D LWV++EY++GG+LTDVVT I+ G I +V +E L+ LEFLH ++HRDIKSDN+LL G +K+TDFGFCAQ+ +R TMVGTPYWMAPEVV+R +Y K+DIWSLGIMIIEM++GEPPY++ETPL+A+Y I T G P K + L+ FL CL ++P R SA LL +++ +
Sbjct: 602 QLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGD--LWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRK-EYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITE 873
BLAST of SMED30035597 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 271.166 bits (692), Expect = 4.947e-82 Identity = 145/312 (46.47%), Postives = 195/312 (62.50%), Query Frame = -2
Query: 252 PVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATA-------------------KETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVV--------TETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLE--SFLHDCLEIDPNLRKSAESLLKHDFL 1100
P K + MS E + L ++ +P +++ E+ G GASG+V LA G+KVAIK M L KQP ++LI+ EI VMK ++H NIVN++E++L +D +LWVV+E+++GG+LTD++ + + + IA +V+E L+FLH+ +IIHRDIKSDNVLL +VK+TDFGFCA+L + S+R TMVGTPYWMAPEVV + +YDEKID+WSLGIM IEML+GEPPY++E PLKA+Y I T G P K LE FL CL +D R S E LL H F
Sbjct: 516 PKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDD-DLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVV-KQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFF 825 HSP 2 Score: 61.6178 bits (148), Expect = 2.028e-10 Identity = 31/82 (37.80%), Postives = 45/82 (54.88%), Query Frame = -2
Query: 1200 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGE 1445
+S+PTN KVHV FDPET FVG+P W+KLL + + E+ + + + F ++Y GN N DK ++GE
Sbjct: 184 VSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNGA-----GNPTNTLDKPQSGE 260
BLAST of SMED30035597 vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 256.914 bits (655), Expect = 3.099e-78 Identity = 134/320 (41.88%), Postives = 189/320 (59.06%), Query Frame = -2
Query: 213 KNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLA-----------------TAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDN----------GLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASI 1085
KN NE + + NP ++L E+ G GASG V L+ + G +VAIK + L +QP + LI+ E+ VM ++ NIVN++E+++I +D+ELWV++EY++GG LTD++ N +A +VKE L+FLH IIHRDIKSDN+LL G VK+TDFGFC +L + S+R TMVGTPYWMAPE+VN+ YDEK+D+WSLGIM+IEM++GEPPY++E PLKA+Y I G P + V + FL CL+++ R S LL +FL S + + S+
Sbjct: 335 KNNDDSNEIIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYII-DDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQK-GYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSPEQLKVSL 652 HSP 2 Score: 58.5362 bits (140), Expect = 1.458e-9 Identity = 24/60 (40.00%), Postives = 39/60 (65.00%), Query Frame = -2
Query: 1266 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDY 1445
+S+PTN KVHV FDP+ +FVG+PD W KLL ++ + ++ ++ + A+ F +DY
Sbjct: 123 VSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDY 182
BLAST of SMED30035597 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 183.341 bits (464), Expect = 5.080e-50 Identity = 105/266 (39.47%), Postives = 153/266 (57.52%), Query Frame = -2
Query: 228 YELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNR-DLILTEIKVMKQ-TQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK---AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKT 1010
++ E +G G G V +TG AIK++NL + + + EI+ + Q NI Y S+L +D LW+++E+ GG+L ++ +D I +++E L AL+ +H++N+IHRDIK+ NVL+ G VK+ DFG AQ+ + RRQTM GTPYWMAPEV+ V YD K+DIWSLGI E+ G PPY D L+A+ I K +P P+ L+ F+ CL+ DP R SA+ LLK F++ K+ T
Sbjct: 23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYL--KDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLI-IKSKP-PRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPT 284
BLAST of SMED30035597 vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 172.555 bits (436), Expect = 2.967e-48 Identity = 103/270 (38.15%), Postives = 150/270 (55.56%), Query Frame = -2
Query: 249 IVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNL-LKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGL----IASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQ-YDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLK 1040
I ++ P Y + +G G G V A + T VAIK++NL + +L+ EI + + + P I NYI + L ED +W+V+EY GG+ +D++ + + NGL ++ ++ E L++LHE IHRDIK+ N+LL + G VK+ DFG + S T +R T VGTPYWMAPEVV V Y+EK DIWSLGI E+L G PP P+K + N+ + P + + F+ CL P R SA +LL +F+K
Sbjct: 8 IRSRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATML--EDVSMWIVMEYCGGGSCSDLLKRSYV-NGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRS-TLKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVK 273
BLAST of SMED30035597 vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0]) HSP 1 Score: 383.259 bits (983), Expect = 3.092e-128 Identity = 213/457 (46.61%), Postives = 279/457 (61.05%), Query Frame = -2
Query: 204 LKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHE--KF--------------------LGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRP--SPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1502
+ F N K+ NKK +P EIS PT + +HV FDP T +F G+P+ W +LL ++ ++ E+ K+P + + + F ++K E KF L + Y K T N + A+ P E K KRKK KMSD E A L IV+ +P KY E++G GASGTV A TG++VAIK MNL +QP ++LI+ EI VM++ +HPNIVNY++S+L+ E ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL ALEFLH N +IHRDIKSDN+LLG GQVK+TDFGFCA + ++R TMVGTPYWMAPEVV R QY ++D+WSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ + FL LE+D R SA LL+H FLKQ K L ++ I AA
Sbjct: 43 FRLFPN-KTEYNKKNKP-EISYPTQFEHTIHVGFDPVTGEFTGMPEAWARLLQVSNITQAEQKKNPQAVLDVLNFYDSSKDKTEPTKFWTTVKPAYDLLFESYWLIRGLSCHQRYAKKTITEHGSSNSVNDDAQPPAIPSRPEHTKSKPSHGQVQARDKRKK-KMSDEEILARLRTIVSIGDPKKKYTKFEKIGQGASGTVYTAIEVATGHEVAIKQMNLSQQPKKELIINEILVMRENKHPNIVNYVDSYLVGE--ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFCATITPEQNKRSTMVGTPYWMAPEVVTRK-QYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPVFKDFLAQSLEMDVEKRSSARELLQHPFLKQAKPLASLVPLILAA 493
BLAST of SMED30035597 vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1]) HSP 1 Score: 247.284 bits (630), Expect = 4.651e-78 Identity = 120/251 (47.81%), Postives = 172/251 (68.53%), Query Frame = -2
Query: 249 RLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLK 995
++G G++G V LAT K TG +VA+K M+L KQ R+L+ E+ +M+ HPNIV S L+ + ELWVV+E+L+GG LTD+VT T + +A V + L AL FLH +IHRDIKSD++LL +G VK++DFGFCAQ+ RR+++VGTPYWMAPEV++R Y ++DIWSLGIM++EM+DGEPPY +E PL+A+ ++ P+ + ++ L+SFL + L DP R +A LL H F++
Sbjct: 34 KIGEGSTGIVCLATDKRTGRQVAVKKMDLKKQQRRELLFNEVVIMRDYPHPNIVEMYGSHLVGD--ELWVVMEFLEGGTLTDIVTHTNLSEEQVACVCRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDFGFCAQVTEDMPRRKSLVGTPYWMAPEVISRK-PYGTEVDIWSLGIMVLEMVDGEPPYFNEPPLQAMRKLRDLEPPTSRNPIQISPRLQSFLDNALIRDPLYRATAFELLNHPFIR 281
BLAST of SMED30035597 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 194.126 bits (492), Expect = 1.773e-57 Identity = 110/294 (37.41%), Postives = 171/294 (58.16%), Query Frame = -2
Query: 204 NEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDL--ILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDV--VTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1067
NE +E +T+ P + +++ E+LG G+ G+V A KE+G VAIK + + + DL I+ EI +M+Q P +V Y S+ ++ +LW+V+EY G+++D+ + + I V+K L LE+LH IHRDIK+ N+LL G K+ DFG QL ++R T++GTP+WMAPEV+ V YD DIWSLGI +EM +G+PPY D P++AI+ I TK P+ + + D + F+ CL +P R +A LL+H F++ K + +++ I A
Sbjct: 6 NELRKLSEESLTRP-PEEVFDVLEKLGEGSYGSVFKAMHKESGQVVAIKQVPV----DTDLQEIIKEISMMQQCDSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-VGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQGAKQISILSSMIQEA 291
BLAST of SMED30035597 vs. Ensembl Nematostella
Match: EDO49047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHW1]) HSP 1 Score: 187.963 bits (476), Expect = 2.743e-55 Identity = 104/275 (37.82%), Postives = 159/275 (57.82%), Query Frame = -2
Query: 234 VTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTET-IMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEV--VNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSP----KAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSL 1037
+++ NP ++L E++G G G V A TG+ A+K++ + + +LI EI +M+Q +H NI+NYI ++ M +LW+ +EY GG++ DV T I+ V E L L +LHE +++HRDIK N+LL +G+VK+ DFG A++ +R++ +GTPYWMAPE+ V RT YD K DIW++GI IEM + +PP D P++A+Y I K P K K ++ F+ L +P R SA+ +L H F C+ L
Sbjct: 9 ISRGNPDKVFDLIEKVGGGTYGDVFKARVIATGDLAAVKVVKVEPGDDFELIQQEIAMMQQCRHNNIINYIGAY--MRRDKLWIGMEYCGGGSIQDVYCVTGPCSETQISFVTVETLKGLAYLHEKSLMHRDIKGANILLTTNGEVKLADFGISARITETMKKRKSFIGTPYWMAPEMAAVERTGGYDLKCDIWAVGITAIEMAELQPPMFDLHPMRALYIIGKKSFIPPTLKEKDKWSNEMHHFIKVALIKNPKKRPSADKMLTHPFC--CRHL 279
BLAST of SMED30035597 vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4]) HSP 1 Score: 184.882 bits (468), Expect = 3.184e-53 Identity = 100/265 (37.74%), Postives = 150/265 (56.60%), Query Frame = -2
Query: 240 KENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILT-EIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCK 1031
K +P + ER+G G+ G V T VAIKI++L + + + EI V+ Q + Y S+L + +LW+++EYL GG+ D++ ++ IA++++E L L++LH +HRDIK+ NVL+ ++G VK+ DFG QL ++R T VGTP+WMAPEV+ ++ YD K DIWSLGI IE+ GEPP D P++ ++ I P + F+ CL DPN R +A+ LLKH F+K K
Sbjct: 4 KADPEKLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYL--KGTKLWIIMEYLGGGSALDLMKAGNIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVIKQSA-YDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPELTGNFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFIKTAK 265
BLAST of SMED30035597 vs. Ensembl Medaka
Match: ENSORLT00000015480.2 (serine/threonine-protein kinase PAK 2 [Source:NCBI gene;Acc:101169249]) HSP 1 Score: 360.918 bits (925), Expect = 2.424e-119 Identity = 196/422 (46.45%), Postives = 269/422 (63.74%), Query Frame = -2
Query: 204 KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1463
K+ P EIS+P++ + +HV FD T +F G+P+ W +LL ++ SK E+ ++P + + F D +K++G+ + + + + P+ PP ++ +Q + K+K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +E L ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ +SFL CLE+D R S + LL+H FLK K L ++ I AA
Sbjct: 67 KDRP-EISSPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNISKLEQKQNPQTVLTILKFY-DSTSGKQKYIGSGQRF---GRLSVYTRSVINPI-----PPPDADSNSQ------AADKQKKKGGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVSTGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFVDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCREVLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFKSFLSRCLEMDVEKRGSGKELLQHPFLKIAKPLSSLTPLILAA 469
BLAST of SMED30035597 vs. Ensembl Medaka
Match: pak2b (p21 (RAC1) activated kinase 2 [Source:NCBI gene;Acc:101167280]) HSP 1 Score: 356.295 bits (913), Expect = 8.467e-117 Identity = 207/476 (43.49%), Postives = 279/476 (58.61%), Query Frame = -2
Query: 204 FFKNLKSGANK---KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETG--EPRDNGLKPVAEEKTPPEI-------------------VETENQKKLETNTST-PV------------------KRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1496
F KSG K KE P EIS P++ + +HV FD T +F G+P+ W +LL ++ +K E+ K+P + + + F + +K+L + +D G P G +P + P I E+ K + T + P+ ++KK+KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +ECL ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ FL+ CLE+D R + LL+H FLK K L ++ I AA
Sbjct: 58 FSGQEKSGRKKDRDKERP-EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTDNGRQKYLSFSSSEKDAFTPGPQSPIKKGSEPSS-----PNIKDIDDDDEDDDEAPPPVVAPRPEHTKSVYTRSVIEPIPAASTGPDGDAASKAADRQKKKSKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLMGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAA 524
BLAST of SMED30035597 vs. Ensembl Medaka
Match: ENSORLT00000028689.1 (serine/threonine-protein kinase PAK 2 [Source:NCBI gene;Acc:101169249]) HSP 1 Score: 352.058 bits (902), Expect = 1.726e-115 Identity = 200/467 (42.83%), Postives = 276/467 (59.10%), Query Frame = -2
Query: 204 MLKFFKNLKSGANK---KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYE---DKDETGEPRDNGLKPVAEEKT-------------------------PPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
++ F K G K K+ P EIS+P++ + +HV FD T +F G+P+ W +LL ++ SK E+ ++P + + F D +K++G+ ++ + + P + + PP ++ +Q + K+K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +E L ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ +SFL CLE+D R S + LL+H FLK K L ++ I AA
Sbjct: 51 IISIFAPEKGGRKKDRDKDRP-EISSPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNISKLEQKQNPQTVLTILKFY-DSTSGKQKYIGSDKDSQLPGKQSTAASPSGKDVDDEDDGDDTPPPIVAPRPPNTISVYTRSVINPIPPPDADSNSQ------AADKQKKKGGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVSTGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFVDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCREVLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFKSFLSRCLEMDVEKRGSGKELLQHPFLKIAKPLSSLTPLILAA 506
BLAST of SMED30035597 vs. Ensembl Medaka
Match: ENSORLT00000043480.1 (serine/threonine-protein kinase PAK 2 [Source:NCBI gene;Acc:101169249]) HSP 1 Score: 352.058 bits (902), Expect = 1.726e-115 Identity = 200/467 (42.83%), Postives = 276/467 (59.10%), Query Frame = -2
Query: 204 MLKFFKNLKSGANK---KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYE---DKDETGEPRDNGLKPVAEEKT-------------------------PPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
++ F K G K K+ P EIS+P++ + +HV FD T +F G+P+ W +LL ++ SK E+ ++P + + F D +K++G+ ++ + + P + + PP ++ +Q + K+K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +E L ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ +SFL CLE+D R S + LL+H FLK K L ++ I AA
Sbjct: 51 IISIFAPEKGGRKKDRDKDRP-EISSPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNISKLEQKQNPQTVLTILKFY-DSTSGKQKYIGSDKDSQLPGKQSTAASPSGKDVDDEDDGDDTPPPIVAPRPPNTISVYTRSVINPIPPPDADSNSQ------AADKQKKKGGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVSTGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFVDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCREVLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFKSFLSRCLEMDVEKRGSGKELLQHPFLKIAKPLSSLTPLILAA 506
BLAST of SMED30035597 vs. Ensembl Medaka
Match: ENSORLT00000030173.1 (serine/threonine-protein kinase PAK 2 [Source:NCBI gene;Acc:101169249]) HSP 1 Score: 352.058 bits (902), Expect = 1.726e-115 Identity = 200/467 (42.83%), Postives = 276/467 (59.10%), Query Frame = -2
Query: 204 MLKFFKNLKSGANK---KEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYE---DKDETGEPRDNGLKPVAEEKT-------------------------PPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
++ F K G K K+ P EIS+P++ + +HV FD T +F G+P+ W +LL ++ SK E+ ++P + + F D +K++G+ ++ + + P + + PP ++ +Q + K+K KM+D E L IV+ +P KY E++G GASGTV A TG +VAIK +NL KQP ++LI+ EI VMK+ ++PNIVN+++SFL+ + EL+VV+EYL GG+LTDVVTET MD IA+V +E L ALEFLH N +IHRDIKSDNVLLG G VK+TDFGFCAQ+ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM++GEPPY++E PL+A+Y I T G P + K+ +SFL CLE+D R S + LL+H FLK K L ++ I AA
Sbjct: 51 IISIFAPEKGGRKKDRDKDRP-EISSPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNISKLEQKQNPQTVLTILKFY-DSTSGKQKYIGSDKDSQLPGKQSTAASPSGKDVDDEDDGDDTPPPIVAPRPPNTISVYTRSVINPIPPPDADSNSQ------AADKQKKKGGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVSTGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFVDSFLVGD--ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCREVLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFKSFLSRCLEMDVEKRGSGKELLQHPFLKIAKPLSSLTPLILAA 506
BLAST of SMED30035597 vs. Planmine SMEST
Match: SMESG000029469.1 (SMESG000029469.1) HSP 1 Score: 892.878 bits (2306), Expect = 0.000e+0 Identity = 434/434 (100.00%), Postives = 434/434 (100.00%), Query Frame = -2
Query: 204 MLKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 1505
MLKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA
Sbjct: 1 MLKFFKNLKSGANKKEEPFEISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFLGNKENYEDKDETGEPRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKAKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQCKSLKTIAASIDAA 434
BLAST of SMED30035597 vs. Planmine SMEST
Match: SMESG000021793.1 (SMESG000021793.1) HSP 1 Score: 337.806 bits (865), Expect = 6.248e-109 Identity = 164/285 (57.54%), Postives = 205/285 (71.93%), Query Frame = -2
Query: 243 RKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQC 1091
++K +MSD + + IV+ +P+ KYEL ER+G GASG V TG KVAIK MNL QP ++L++ EI VMK HPNIVNY++S+L+ D ELWVV+EYLDGG+LT+VVTET M+ G IA+V +ECL AL+FLHE +IHRDIKSDN+LLG G VK+ DFGFCAQL S +R TMVGTPYWMAPEVV + QY K+DIWSLGIM IEM+DGEPPY++E PL+A+Y I T G+P K K+ SFL + L +D +R SA LL H F+KQC
Sbjct: 297 KRKARMSDEQISEKIRAIVSLGDPIRKYELKERIGQGASGIVNSGIEISTGKKVAIKQMNLKSQPKKELLINEIYVMKANHHPNIVNYLDSYLLPHD-ELWVVMEYLDGGSLTEVVTETYMEEGHIAAVSRECLQALKFLHERKVIHRDIKSDNILLGIDGSVKLIDFGFCAQLSSEQMKRSTMVGTPYWMAPEVVAKK-QYGPKVDIWSLGIMAIEMIDGEPPYLNENPLRALYLIATNGKPEIKERDKLSSLFISFLDNSLSVDVEMRSSAADLLVHPFIKQC 579 HSP 2 Score: 54.299 bits (129), Expect = 1.881e-7 Identity = 25/68 (36.76%), Postives = 42/68 (61.76%), Query Frame = -2
Query: 1242 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFL 1445
IS P +V K+H+TF ET +F G+P W ++L+ + SK E+ ++PN + +A+ F D +KF+
Sbjct: 70 ISAPISVTHKLHITFCSETGEFTGMPPEWMRMLED-NISKVEQQQNPNAVVSALNFFADKNHTKDKFM 136
BLAST of SMED30035597 vs. Planmine SMEST
Match: SMESG000021793.1 (SMESG000021793.1) HSP 1 Score: 337.421 bits (864), Expect = 1.666e-108 Identity = 164/285 (57.54%), Postives = 205/285 (71.93%), Query Frame = -2
Query: 243 RKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPKA--KVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQC 1091
++K +MSD + + IV+ +P+ KYEL ER+G GASG V TG KVAIK MNL QP ++L++ EI VMK HPNIVNY++S+L+ D ELWVV+EYLDGG+LT+VVTET M+ G IA+V +ECL AL+FLHE +IHRDIKSDN+LLG G VK+ DFGFCAQL S +R TMVGTPYWMAPEVV + QY K+DIWSLGIM IEM+DGEPPY++E PL+A+Y I T G+P K K+ SFL + L +D +R SA LL H F+KQC
Sbjct: 315 KRKARMSDEQISEKIRAIVSLGDPIRKYELKERIGQGASGIVNSGIEISTGKKVAIKQMNLKSQPKKELLINEIYVMKANHHPNIVNYLDSYLLPHD-ELWVVMEYLDGGSLTEVVTETYMEEGHIAAVSRECLQALKFLHERKVIHRDIKSDNILLGIDGSVKLIDFGFCAQLSSEQMKRSTMVGTPYWMAPEVVAKK-QYGPKVDIWSLGIMAIEMIDGEPPYLNENPLRALYLIATNGKPEIKERDKLSSLFISFLDNSLSVDVEMRSSAADLLVHPFIKQC 597 HSP 2 Score: 54.299 bits (129), Expect = 1.765e-7 Identity = 25/68 (36.76%), Postives = 42/68 (61.76%), Query Frame = -2
Query: 1242 ISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFL 1445
IS P +V K+H+TF ET +F G+P W ++L+ + SK E+ ++PN + +A+ F D +KF+
Sbjct: 88 ISAPISVTHKLHITFCSETGEFTGMPPEWMRMLED-NISKVEQQQNPNAVVSALNFFADKNHTKDKFM 154
BLAST of SMED30035597 vs. Planmine SMEST
Match: SMESG000036933.1 (SMESG000036933.1) HSP 1 Score: 333.954 bits (855), Expect = 4.779e-107 Identity = 164/294 (55.78%), Postives = 211/294 (71.77%), Query Frame = -2
Query: 246 ETNTSTPVKRKKN-KMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFLKQ 1118
E + S P R K K+SD E L +V+ +PL+KY L+E++G GASG V +T K TG +AIK M L QP +DLI+ EI VM+ +HPNIVNY++SFL+ ++KELWVV+EYLDGG+LTDVVTE M IA+V +E L ALEFLH ++IHRDIKSDN+LLG GQVK+TDFGFCAQL + ++R TMVGTPYWMAPEVV + QY K+D+WSLGIM +EMLDGEPPY++E P+KA+Y I T G+P K + + + FL CLE+D R SA LL H F+++
Sbjct: 323 EKSNSAPRTRSKPVKVSDKEVIDRLKLVVSAGDPLEKYVLDEKVGQGASGVVYSSTNKSTGKPLAIKQMTLASQPKKDLIVNEILVMRAHRHPNIVNYLDSFLVDDNKELWVVMEYLDGGSLTDVVTEAFMQENQIATVCRETLQALEFLHSKHVIHRDIKSDNILLGLDGQVKLTDFGFCAQLSNDLTKRTTMVGTPYWMAPEVVTKK-QYGPKVDVWSLGIMALEMLDGEPPYLNENPIKALYLIATNGKPDVKEAQNMSTEFKDFLDCCLEVDVEKRWSASDLLNHPFIQK 615 HSP 2 Score: 50.447 bits (119), Expect = 3.114e-6 Identity = 24/69 (34.78%), Postives = 37/69 (53.62%), Query Frame = -2
Query: 1242 EISNPTNVQKKVHVTFDPETSDFVGLPDYWKKLLDQADFSKEEKTKHPNEIYNAVIFMKDYEEKHEKFL 1448
EIS PT V ++HV FD +T GLP W +L ++ SK ++ K+P I + D + +KF+
Sbjct: 65 EISAPTCVSHELHVEFDAQTGQINGLPQAWSNMLTASNISKVDQEKNPEVIMEVLQCFNDAAKSKQKFM 133
BLAST of SMED30035597 vs. Planmine SMEST
Match: SMESG000009652.1 (SMESG000009652.1) HSP 1 Score: 315.849 bits (808), Expect = 7.464e-104 Identity = 163/318 (51.26%), Postives = 212/318 (66.67%), Query Frame = -2
Query: 252 PRDNGLKPVAEEKTPPEIVETENQKKLETNTSTPVKRKKNKMSDNEFYAALDEIVTKENPLDKYELNERLGAGASGTVRLATAKETGNKVAIKIMNLLKQPNRDLILTEIKVMKQTQHPNIVNYIESFLIMEDKELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALEFLHENNIIHRDIKSDNVLLGKSGQVKVTDFGFCAQLGSRTSRRQTMVGTPYWMAPEVVNRTVQYDEKIDIWSLGIMIIEMLDGEPPYMDETPLKAIYNIQTKGRPSPK--AKVDGDLESFLHDCLEIDPNLRKSAESLLKHDFL 1199
P + + P + K I ++Q + + + ++R S F + L +V+ +P KYE+ +R+G GASG V ET KVAIK MNL +QP +DLIL EI V+K +H NIVNY++SF++ + ELWVV+EYLDGG+LTDVVTE MD IA++ +E AL FLH N++IHRDIKSDN+LLG G VK+ DFGFCAQL + R TMVGTPYWMAPEVV R QY K+D+WSLGIM+IEML+GEPPY++E PL+A+Y I T G+PS K V FL CLE+D + R SA SLLKH+F+
Sbjct: 3 PTGDSVTPCDKSKDSVSIEINQSQNRCDRHQQ--LRRADRHCSGEFFISKLKGVVSSSDPYSKYEILDRIGQGASGVVMGGRDLETKKKVAIKQMNLKQQPKKDLILNEILVIKANKHQNIVNYLDSFIM--NNELWVVMEYLDGGSLTDVVTEACMDEFQIATICREVTMALGFLHSNHVIHRDIKSDNILLGLDGSVKIIDFGFCAQLIGGRNNRSTMVGTPYWMAPEVVTRK-QYGPKVDLWSLGIMVIEMLEGEPPYLNENPLRALYLIATNGKPSLKDPTTVSPLFLDFLDRCLEVDIDKRASASSLLKHEFI 315 The following BLAST results are available for this feature:
BLAST of SMED30035597 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of SMED30035597 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of SMED30035597 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of SMED30035597 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of SMED30035597 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035597 ID=SMED30035597|Name=SMED30035597|organism=Schmidtea mediterranea sexual|type=transcript|length=1605bpback to top protein sequence of SMED30035597-orf-1 >SMED30035597-orf-1 ID=SMED30035597-orf-1|Name=SMED30035597-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=473bp MNYLKIFQIIFVVCLNKLFSLLNYFGSYFFMLKFFKNLKSGANKKEEPFEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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