NPHS1-7
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035538 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of NPHS1-7 vs. Ensembl Human
Match: NPHS1 (NPHS1 adhesion molecule, nephrin [Source:HGNC Symbol;Acc:HGNC:7908]) HSP 1 Score: 76.2554 bits (186), Expect = 3.151e-13 Identity = 127/518 (24.52%), Postives = 203/518 (39.19%), Query Frame = 3
Query: 792 YLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPENEI------GDVLSIECSSVGGFPVPNYEIYI-----------MREGKDFETFT-EKTIILTKE--DNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK---LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISW 2243
+L I D EC V +S M P VI S+ V +LL L PE G + C S P P+ I + + EG + FT E T +T DN L+ C A I+++ F ++V +PP +E + E + + ++ C + G NP AT+QW KN + S + ++ +A+ SV+ G ++C+A N++ G ++ L V F P AI I ++S EN+ + L+C S P L+W + + + T M G +GG S L R + C +F T T S +LN+ Y P+ K++ P K++ V L C I GNP+ + Y +SR T ++ + + + S S S + V Q T +G+ S L V+F P ++ P + +N +S V +SW
Sbjct: 95 HLHIEACDLSDDAEYECQV-GRSEMGPELVSPRVILSI--LVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKAS-FTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGG-NPLATLQWL---KNGQPVSTAWGTEHT-------QAVARSVLVMTVRPEDHGAQLSCEA--HNSVSAGTQEHGITLQVTFPPSAI--IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEET------VMDGLHGGHISMSNLTFL-ARREDNGLTLTCEAFSEAFTKETFKKSLILNVKY-PAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK----DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ-LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSW 580
BLAST of NPHS1-7 vs. Ensembl Human
Match: NPHS1 (NPHS1 adhesion molecule, nephrin [Source:HGNC Symbol;Acc:HGNC:7908]) HSP 1 Score: 75.8702 bits (185), Expect = 4.192e-13 Identity = 127/518 (24.52%), Postives = 203/518 (39.19%), Query Frame = 3
Query: 792 YLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPENEI------GDVLSIECSSVGGFPVPNYEIYI-----------MREGKDFETFT-EKTIILTKE--DNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK---LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISW 2243
+L I D EC V +S M P VI S+ V +LL L PE G + C S P P+ I + + EG + FT E T +T DN L+ C A I+++ F ++V +PP +E + E + + ++ C + G NP AT+QW KN + S + ++ +A+ SV+ G ++C+A N++ G ++ L V F P AI I ++S EN+ + L+C S P L+W + + + T M G +GG S L R + C +F T T S +LN+ Y P+ K++ P K++ V L C I GNP+ + Y +SR T ++ + + + S S S + V Q T +G+ S L V+F P ++ P + +N +S V +SW
Sbjct: 95 HLHIEACDLSDDAEYECQVG-RSEMGPELVSPRVILSI--LVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKAS-FTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGG-NPLATLQWL---KNGQPVSTAWGTEHT-------QAVARSVLVMTVRPEDHGAQLSCEA--HNSVSAGTQEHGITLQVTFPPSAI--IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEET------VMDGLHGGHISMSNLTFL-ARREDNGLTLTCEAFSEAFTKETFKKSLILNVKY-PAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK----DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ-LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSW 580
BLAST of NPHS1-7 vs. Ensembl Human
Match: CD22 (CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643]) HSP 1 Score: 56.9954 bits (136), Expect = 2.328e-7 Identity = 60/232 (25.86%), Postives = 111/232 (47.84%), Query Frame = 3
Query: 1485 LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSES---HPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLK-SELIVHE---TSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP--SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLST 2153
LNV P I + P I E+Q + LTC ++ S +P+ +L+W + +G+ ++ T+ + +LK S H + Q+ + K LS +D+ LN+ + P +K+ PS ++E D V + C + NP++ SW+ K+ ++ K+ N+ + ++ + VT SGKY C +++ G G S E FL+V++ P+ ++T
Sbjct: 134 LNVSERPFPPHIQLPPE--IQESQEVTLTCLLNFSCYGYPI-QLQW--LLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLS---------NDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT--VSWL----------KDGTSLKK--QNTFT-LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYPPKKVTT 336
BLAST of NPHS1-7 vs. Ensembl Human
Match: CD22 (CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643]) HSP 1 Score: 55.0694 bits (131), Expect = 9.232e-7 Identity = 63/260 (24.23%), Postives = 117/260 (45.00%), Query Frame = 3
Query: 1485 LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSES---HPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTIS-DSFVLNILYNP--SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWF 2246
LNV P I + P I E+Q + LTC ++ S +P+ +L+W+ + VT+ SL + F +SEL + + S + + G +S D+ LN+ + P +K+ PS ++E D V + C + NP++ SW+ K+ ++ K+ N+ + ++ + VT SGKY C +++ G G S E FL+V++ P + + + F+ ++ P +W+
Sbjct: 134 LNVSERPFPPHIQLPPE--IQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTS-TSLTIKSVF-----TRSELKF--SPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT--VSWL----------KDGTSLKK--QNTFT-LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWY 367
BLAST of NPHS1-7 vs. Ensembl Human
Match: CD22 (CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643]) HSP 1 Score: 54.6842 bits (130), Expect = 1.101e-6 Identity = 62/263 (23.57%), Postives = 118/263 (44.87%), Query Frame = 3
Query: 1485 LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSES---HPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLK-SELIVHE---TSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP--SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWF 2246
LNV P I + P I E+Q + LTC ++ S +P+ +L+W + +G+ ++ T+ + +LK S H + Q+ + K LS +D+ LN+ + P +K+ PS ++E D V + C + NP++ SW+ K+ ++ K+ N+ + ++ + VT SGKY C +++ G G S E FL+V++ P + + + F+ ++ P +W+
Sbjct: 134 LNVSERPFPPHIQLPPE--IQESQEVTLTCLLNFSCYGYPI-QLQW--LLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLS---------NDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT--VSWL----------KDGTSLKK--QNTFT-LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWY 367
BLAST of NPHS1-7 vs. Ensembl Celegans
Match: syg-2 (Synaptogenesis protein syg-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9U3P2]) HSP 1 Score: 51.2174 bits (121), Expect = 4.725e-6 Identity = 44/174 (25.29%), Postives = 85/174 (48.85%), Query Frame = 3
Query: 1404 ANKNQSGIIINCDAIYK-NNIIPGPEKLLNVIFSPDAIKITIKPN-SSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP-SVKIFPSSNKIKESDYVELRCNLIQGNP 1916
+++N G +I C+A K +I L+V+F P + I N S++ + + CSV+ +P ++ W NK + +H++L T + +++K+ + S++ EY+C + +S+TG + L + Y P SV++F SN I+ ++C + NP
Sbjct: 198 SDRNDHGKVITCEAFQKETDIRITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVTIACSVTGGNPPPDVFWYHENKRL-----QSHSTLDTRS-----KEIKN-IYSFIASQNDNMAEYECRANNSRTGNPKRKAMKLEVNYPPASVELFGESN-IRYGSSANIQCKSLPSNP 359
BLAST of NPHS1-7 vs. Ensembl Celegans
Match: syg-2 (Synaptogenesis protein syg-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9U3P2]) HSP 1 Score: 51.2174 bits (121), Expect = 4.755e-6 Identity = 44/174 (25.29%), Postives = 85/174 (48.85%), Query Frame = 3
Query: 1404 ANKNQSGIIINCDAIYK-NNIIPGPEKLLNVIFSPDAIKITIKPN-SSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP-SVKIFPSSNKIKESDYVELRCNLIQGNP 1916
+++N G +I C+A K +I L+V+F P + I N S++ + + CSV+ +P ++ W NK + +H++L T + +++K+ + S++ EY+C + +S+TG + L + Y P SV++F SN I+ ++C + NP
Sbjct: 198 SDRNDHGKVITCEAFQKETDIRITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVTIACSVTGGNPPPDVFWYHENKRL-----QSHSTLDTRS-----KEIKN-IYSFIASQNDNMAEYECRANNSRTGNPKRKAMKLEVNYPPASVELFGESN-IRYGSSANIQCKSLPSNP 359
BLAST of NPHS1-7 vs. Ensembl Fly
Match: hbs (gene:FBgn0029082 transcript:FBtr0087413) HSP 1 Score: 74.7146 bits (182), Expect = 4.196e-13 Identity = 127/559 (22.72%), Postives = 224/559 (40.07%), Query Frame = 3
Query: 843 LVYEKSNMIAFQ--RIPLVIHSLPSKVNIQLLGLKPENEIGDVLSIECS------------SVGGFPVPNYEIYIMREGKDFETFTEKTIILT--KEDNNLLMKCRALQAG-THNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGP---EKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESD---YVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKP-KKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIG 2447
LV E N++A R L + L + ++ L G + ++GD + + C S+ G P+ N Y D + I LT + + C AL T N + S+ ++V YPP + + +I+ + I + + +G NPP T+QW YKN + ++ +S + + N + + I C +N I P K L V F P+ +KI++ P +++ L C S S+P +++ W K GI E + +L G +GG E+ V+ T + + Y C S + ++ ++ L+ILY P + S+ + +VEL L GNP I Y+W ++ NS + + + ++ ++ D+G Y C + G E + VE+ P ++ + + EP ++P + + W ++D D +T R SSF ENG L I+ + +D G + C + N+ G
Sbjct: 321 LVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGAN-QAKVGDSVQLSCVTAPSNPQARISWSINGRPLDN-STYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHT--VNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQW------YKNDKIINAPSKLV------DSKITSELSLLVNASDNNAIYKCKV--QNAAIDIPLFATKTLGVHFPPETVKISVVPK-NLVPGIRAKLICDSSSSNPPAKISWWK--DGIPVEGL----NLANRPGLWGGSVSTLEMYVNIT-QDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVEL---LASGNPMVI--TYTW----TKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQGTALL-EIQVAVEYAP-TITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRW-----SRDG------------YDLAT------RTISSF-ENGTALLQIASVERSDIGNFTCIVDNQRG 818
BLAST of NPHS1-7 vs. Ensembl Fly
Match: hbs (gene:FBgn0029082 transcript:FBtr0087414) HSP 1 Score: 74.3294 bits (181), Expect = 5.376e-13 Identity = 127/559 (22.72%), Postives = 224/559 (40.07%), Query Frame = 3
Query: 843 LVYEKSNMIAFQ--RIPLVIHSLPSKVNIQLLGLKPENEIGDVLSIECS------------SVGGFPVPNYEIYIMREGKDFETFTEKTIILT--KEDNNLLMKCRALQAG-THNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGP---EKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESD---YVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKP-KKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIG 2447
LV E N++A R L + L + ++ L G + ++GD + + C S+ G P+ N Y D + I LT + + C AL T N + S+ ++V YPP + + +I+ + I + + +G NPP T+QW YKN + ++ +S + + N + + I C +N I P K L V F P+ +KI++ P +++ L C S S+P +++ W K GI E + +L G +GG E+ V+ T + + Y C S + ++ ++ L+ILY P + S+ + +VEL L GNP I Y+W ++ NS + + + ++ ++ D+G Y C + G E + VE+ P ++ + + EP ++P + + W ++D D +T R SSF ENG L I+ + +D G + C + N+ G
Sbjct: 321 LVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGAN-QAKVGDSVQLSCVTAPSNPQARISWSINGRPLDN-STYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHT--VNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQW------YKNDKIINAPSKLV------DSKITSELSLLVNASDNNAIYKCKV--QNAAIDIPLFATKTLGVHFPPETVKISVVPK-NLVPGIRAKLICDSSSSNPPAKISWWK--DGIPVEGL----NLANRPGLWGGSVSTLEMYVNIT-QDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVEL---LASGNPMVI--TYTW----TKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQGTALL-EIQVAVEYAP-TITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRW-----SRDG------------YDLAT------RTISSF-ENGTALLQIASVERSDIGNFTCIVDNQRG 818
BLAST of NPHS1-7 vs. Ensembl Fly
Match: hbs (gene:FBgn0029082 transcript:FBtr0345419) HSP 1 Score: 74.3294 bits (181), Expect = 5.376e-13 Identity = 127/559 (22.72%), Postives = 224/559 (40.07%), Query Frame = 3
Query: 843 LVYEKSNMIAFQ--RIPLVIHSLPSKVNIQLLGLKPENEIGDVLSIECS------------SVGGFPVPNYEIYIMREGKDFETFTEKTIILT--KEDNNLLMKCRALQAG-THNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGP---EKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESD---YVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKP-KKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIG 2447
LV E N++A R L + L + ++ L G + ++GD + + C S+ G P+ N Y D + I LT + + C AL T N + S+ ++V YPP + + +I+ + I + + +G NPP T+QW YKN + ++ +S + + N + + I C +N I P K L V F P+ +KI++ P +++ L C S S+P +++ W K GI E + +L G +GG E+ V+ T + + Y C S + ++ ++ L+ILY P + S+ + +VEL L GNP I Y+W ++ NS + + + ++ ++ D+G Y C + G E + VE+ P ++ + + EP ++P + + W ++D D +T R SSF ENG L I+ + +D G + C + N+ G
Sbjct: 321 LVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGAN-QAKVGDSVQLSCVTAPSNPQARISWSINGRPLDN-STYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHT--VNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQW------YKNDKIINAPSKLV------DSKITSELSLLVNASDNNAIYKCKV--QNAAIDIPLFATKTLGVHFPPETVKISVVPK-NLVPGIRAKLICDSSSSNPPAKISWWK--DGIPVEGL----NLANRPGLWGGSVSTLEMYVNIT-QDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVEL---LASGNPMVI--TYTW----TKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQGTALL-EIQVAVEYAP-TITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRW-----SRDG------------YDLAT------RTISSF-ENGTALLQIASVERSDIGNFTCIVDNQRG 818
BLAST of NPHS1-7 vs. Ensembl Fly
Match: side-VII (gene:FBgn0037736 transcript:FBtr0082170) HSP 1 Score: 67.3958 bits (163), Expect = 7.509e-11 Identity = 98/407 (24.08%), Postives = 179/407 (43.98%), Query Frame = 3
Query: 957 GDVLSIECSSVGGFPVPNYEIYIMREGK----DFETFTEKTII--------LTKEDNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKL-----LNVIFSPDA---IKITIKPNSSIMENQTIILTCSVSESHP-VSELKWVKINKGIFNEDVTAH-ASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSV-----KIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGK 2096
GD++S++C +GG+P P Y R+G + II L +ED N + CRAL +E+ V + F P L ++++ + + + + +GS PPA I W ++N + +T + + T+S + +K+ +G ++C A N+ +P E L L++ + P+A + ++ P S++ E + C V +HP V ++W NE +H SL + + L++ +R++ Y C+ F+++ G IS F LNILY P+ K++ I + + ++ C + NP+ + +SW F S +S N I S + S +++ +T D G CL ++ GK
Sbjct: 161 GDIVSLKCQVIGGYPTPTISWY--RDGIEIPCELSHLAGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAP---LNIRLLGAHQPLSAGRRYDLLCQSAGSRPPAVITW------WQN-GIRLEKTTETTSSDGNQ--TTSTLSISLSKSDAGKYLSCKAY--NHAVPS-EPLEDGWKLDIQYVPEAYVRLGTSLDP-STLREGTDVYFDCLVM-AHPNVFRIEWR------HNEQPLSHNISLGVIISNH-------SLVLQGVTRATAG-NYSCVGFNAE-GEGISAPFALNILYAPTCAQNQKKVY----GIAKQEDAKVMCT-VDANPREV--EFSWTFNNSAESIDVATN---HIIRSGTTSIVTYTPITELDYGTLLCLASNKIGK 523 HSP 2 Score: 55.0694 bits (131), Expect = 4.457e-7 Identity = 75/328 (22.87%), Postives = 130/328 (39.63%), Query Frame = 3
Query: 1485 LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSF-HSKTGVTISDSFVLNILYNP------SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIG 2447
+++ F+P I++ + + + + L C + S P + + W + GI E T S G Q S L + S+S C ++ H+ + D + L+I Y P + PS+ ++E V C L+ +P W E S N + IISN + Q VT +G Y C+ + G+G S F L + + P KKV +E + + P++VE SW +++ +S+ + N I+ G + ++ + I E D+G +C SN+IG
Sbjct: 238 IDMNFAPLNIRL-LGAHQPLSAGRRYDLLCQSAGSRPPAVITWWQ--NGIRLEKTTETTSSD-------GNQTTSTLSI-SLSKSDAGKYLSCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPST--LREGTDVYFDC-LVMAHPNVF--RIEWRHNEQPLS----HNISLGVIISNH--SLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANPREVEFSWTF-NNSAESIDVATNH-----------IIRSGT---------TSIVTYTPITELDYGTLLCLASNKIG 522
BLAST of NPHS1-7 vs. Ensembl Fly
Match: side-VII (gene:FBgn0037736 transcript:FBtr0331695) HSP 1 Score: 67.3958 bits (163), Expect = 7.509e-11 Identity = 98/407 (24.08%), Postives = 179/407 (43.98%), Query Frame = 3
Query: 957 GDVLSIECSSVGGFPVPNYEIYIMREGK----DFETFTEKTII--------LTKEDNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKL-----LNVIFSPDA---IKITIKPNSSIMENQTIILTCSVSESHP-VSELKWVKINKGIFNEDVTAH-ASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSV-----KIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGK 2096
GD++S++C +GG+P P Y R+G + II L +ED N + CRAL +E+ V + F P L ++++ + + + + +GS PPA I W ++N + +T + + T+S + +K+ +G ++C A N+ +P E L L++ + P+A + ++ P S++ E + C V +HP V ++W NE +H SL + + L++ +R++ Y C+ F+++ G IS F LNILY P+ K++ I + + ++ C + NP+ + +SW F S +S N I S + S +++ +T D G CL ++ GK
Sbjct: 161 GDIVSLKCQVIGGYPTPTISWY--RDGIEIPCELSHLAGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAP---LNIRLLGAHQPLSAGRRYDLLCQSAGSRPPAVITW------WQN-GIRLEKTTETTSSDGNQ--TTSTLSISLSKSDAGKYLSCKAY--NHAVPS-EPLEDGWKLDIQYVPEAYVRLGTSLDP-STLREGTDVYFDCLVM-AHPNVFRIEWR------HNEQPLSHNISLGVIISNH-------SLVLQGVTRATAG-NYSCVGFNAE-GEGISAPFALNILYAPTCAQNQKKVY----GIAKQEDAKVMCT-VDANPREV--EFSWTFNNSAESIDVATN---HIIRSGTTSIVTYTPITELDYGTLLCLASNKIGK 523 HSP 2 Score: 55.0694 bits (131), Expect = 4.457e-7 Identity = 75/328 (22.87%), Postives = 130/328 (39.63%), Query Frame = 3
Query: 1485 LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSF-HSKTGVTISDSFVLNILYNP------SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIG 2447
+++ F+P I++ + + + + L C + S P + + W + GI E T S G Q S L + S+S C ++ H+ + D + L+I Y P + PS+ ++E V C L+ +P W E S N + IISN + Q VT +G Y C+ + G+G S F L + + P KKV +E + + P++VE SW +++ +S+ + N I+ G + ++ + I E D+G +C SN+IG
Sbjct: 238 IDMNFAPLNIRL-LGAHQPLSAGRRYDLLCQSAGSRPPAVITWWQ--NGIRLEKTTETTSSD-------GNQTTSTLSI-SLSKSDAGKYLSCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPST--LREGTDVYFDC-LVMAHPNVF--RIEWRHNEQPLS----HNISLGVIISNH--SLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANPREVEFSWTF-NNSAESIDVATNH-----------IIRSGT---------TSIVTYTPITELDYGTLLCLASNKIG 522
BLAST of NPHS1-7 vs. Ensembl Zebrafish
Match: si:ch211-152f2.2 (si:ch211-152f2.2 [Source:ZFIN;Acc:ZDB-GENE-121214-75]) HSP 1 Score: 62.7734 bits (151), Expect = 1.585e-9 Identity = 87/334 (26.05%), Postives = 129/334 (38.62%), Query Frame = 3
Query: 1473 PEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNV-EYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLS-TFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYS 2459
PE LNV + P +I ++I ++ IM ++ L+CS S+S+P +E+ W F G + L S I SS + EYKC + ++ GV SD L++ Y P SV I S+ I D V L C+ P I SW F E S I S ++ DSG+Y C ++ G+ +S L+V++ PR S + + + + S P + SW+ K S V GR + SIS+I D G Y C+ N+ G YS
Sbjct: 212 PEVYLNVTYPPKSILVSISGSAVIMSGDSVTLSCS-SDSNPPAEISW-----------------------FKGKKYLNSGRIFRIPKISSDDSGEYKCRA-RNEHGVKYSDPVTLDVQYPPRNISVSISGSA-VIMSGDSVTLNCSSDSNPPAEI----SW---------FKGETSVGSGRI------FSISKISSDDSGEYNCSASNKHGEKYSDPVTLDVQYPPRRASVSINPSAVIMSGDSVTLSCSSDSNPPALNFSWY-----KGDTS-----------------VGSGRLY-----------SISKISSGDSGEYKCRARNDHGEKYS 467 HSP 2 Score: 57.7658 bits (138), Expect = 6.048e-8 Identity = 92/378 (24.34%), Postives = 145/378 (38.36%), Query Frame = 3
Query: 1038 KDFETFTEKTIILTKEDNNLLMKCRALQAGT-------HNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPR 2141
++ T TE++ L LL R AG H V++ +V YPP + + I I+ + C S SNPPA I W F K Y N S K + GE + +N+ G+ Y + + L+V + P I ++I ++ IM ++ L CS S+S+P +E+ W K + + + S + EY C S +K G SD L++ Y P SV I PS+ I D V L C+ P N+SW ++ + S L IS ++ DSG+Y+C + G+ +S L +++ R
Sbjct: 175 RNSHTLTERSSEL------LLQSVRRQDAGRYRCAVDGHTLTSPEVYL-NVTYPPKSILVSISGSAVIMSGDSVTLSC--SSDSNPPAEISW-FKGKKYLN-SGRIFRIPKISSDDSGEYKCRA-------RNEHGVK------YSDPVT------LDVQYPPRNISVSISGSAVIMSGDSVTLNCS-SDSNPPAEISWFKGETSVGS----------------------GRIFSISKISSDDSGEYNC-SASNKHGEKYSDPVTLDVQYPPRRASVSINPSA-VIMSGDSVTLSCSSDSNPPAL---NFSWYKGDT-------------SVGSGRLYSIS--KISSGDSGEYKCRARNDHGEKYSDPVTLSIQWAGR 479
BLAST of NPHS1-7 vs. Ensembl Zebrafish
Match: cadm2a (cell adhesion molecule 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1614]) HSP 1 Score: 56.6102 bits (135), Expect = 9.091e-8 Identity = 55/194 (28.35%), Postives = 89/194 (45.88%), Query Frame = 3
Query: 1542 IMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSF-VLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFL 2120
++E I LTC S S P ++++W K N+ +AS KT T +KS L +H +R V Y C H T ++ VL + Y P V+I S+N +E Y++L+C + +GNP W + E + +I + D++F ++ D+G Y+C T+ G + EF L
Sbjct: 116 VLEGDHITLTCVTSGSKPAADVRWFK-NEMEVKGAKEVNASGKTFT-------VKSSLRLH-VNRDDDGVAYTCRVDHVALTATHEETTQVLEVHYAPYVEIRQSTNVPQEGQYLKLQC-VPKGNPS--PDPVLW-------TKDGGELPDMDRMIVDG-RDLTFTSLNKTDNGTYRCEATNHLGTSHA-EFKL 288
BLAST of NPHS1-7 vs. Ensembl Zebrafish
Match: cadm2a (cell adhesion molecule 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1614]) HSP 1 Score: 56.6102 bits (135), Expect = 1.003e-7 Identity = 55/194 (28.35%), Postives = 89/194 (45.88%), Query Frame = 3
Query: 1542 IMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSF-VLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFL 2120
++E I LTC S S P ++++W K N+ +AS KT T +KS L +H +R V Y C H T ++ VL + Y P V+I S+N +E Y++L+C + +GNP W + E + +I + D++F ++ D+G Y+C T+ G + EF L
Sbjct: 116 VLEGDHITLTCVTSGSKPAADVRWFK-NEMEVKGAKEVNASGKTFT-------VKSSLRLH-VNRDDDGVAYTCRVDHVALTATHEETTQVLEVHYAPYVEIRQSTNVPQEGQYLKLQC-VPKGNPS--PDPVLW-------TKDGGELPDMDRMIVDG-RDLTFTSLNKTDNGTYRCEATNHLGTSHA-EFKL 288
BLAST of NPHS1-7 vs. Ensembl Zebrafish
Match: cadm2a (cell adhesion molecule 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1614]) HSP 1 Score: 56.6102 bits (135), Expect = 1.160e-7 Identity = 55/194 (28.35%), Postives = 89/194 (45.88%), Query Frame = 3
Query: 1542 IMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSF-VLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFL 2120
++E I LTC S S P ++++W K N+ +AS KT T +KS L +H +R V Y C H T ++ VL + Y P V+I S+N +E Y++L+C + +GNP W + E + +I + D++F ++ D+G Y+C T+ G + EF L
Sbjct: 105 VLEGDHITLTCVTSGSKPAADVRWFK-NEMEVKGAKEVNASGKTFT-------VKSSLRLH-VNRDDDGVAYTCRVDHVALTATHEETTQVLEVHYAPYVEIRQSTNVPQEGQYLKLQC-VPKGNPS--PDPVLW-------TKDGGELPDMDRMIVDG-RDLTFTSLNKTDNGTYRCEATNHLGTSHA-EFKL 277
BLAST of NPHS1-7 vs. Ensembl Zebrafish
Match: cadm2a (cell adhesion molecule 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1614]) HSP 1 Score: 56.225 bits (134), Expect = 1.311e-7 Identity = 55/194 (28.35%), Postives = 89/194 (45.88%), Query Frame = 3
Query: 1542 IMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSF-VLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFL 2120
++E I LTC S S P ++++W K N+ +AS KT T +KS L +H +R V Y C H T ++ VL + Y P V+I S+N +E Y++L+C + +GNP W + E + +I + D++F ++ D+G Y+C T+ G + EF L
Sbjct: 105 VLEGDHITLTCVTSGSKPAADVRWFK-NEMEVKGAKEVNASGKTFT-------VKSSLRLH-VNRDDDGVAYTCRVDHVALTATHEETTQVLEVHYAPYVEIRQSTNVPQEGQYLKLQC-VPKGNPS--PDPVLW-------TKDGGELPDMDRMIVDG-RDLTFTSLNKTDNGTYRCEATNHLGTSHA-EFKL 277
BLAST of NPHS1-7 vs. Ensembl Xenopus
Match: prdx1 (peroxiredoxin 1 [Source:Xenbase;Acc:XB-GENE-481165]) HSP 1 Score: 65.4698 bits (158), Expect = 5.024e-10 Identity = 79/336 (23.51%), Postives = 145/336 (43.15%), Query Frame = 3
Query: 1524 IKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGI--------FNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSN---CKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIP 2498
I+ N++ +++++L+C ++ P E+ W+K + I FNED KSE+ ++ + + EY C++ ++K G +++ +L +Y + + E D + L C G+P I + SW S+ K KE I +S ++ + + D+G+Y C+ ++ G+ +F EV++ P++ V+ T P+N + ++ P V +SWF +D + ++ +FS I + G SS L ++ ENDFG Y C N IG S F LV ++ P
Sbjct: 192 IRVNATANMDESVVLSCD-ADGFPDPEISWLKKGEPIEDGEEKISFNED-------------------KSEMTIYRVGKDDE-AEYSCIA-NNKAGE--AEAIILLKVYAKPKITYVENKTAVELDEITLTCEA-SGDP---IPSISWRTATRNISSEEKTLDGHIVVKEHIR--MSALTLKDIQYTDAGEYICIASNAIGEDMRAMYF-EVQYAPKIKGPV--VVYTWEGNPVNITCEVLAYPSAV-VSWF-----RDGQLLPSS-------NFSNIKIYSGPSSSS--------LEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPSSP 473
BLAST of NPHS1-7 vs. Ensembl Xenopus
Match: prdx1 (peroxiredoxin 1 [Source:Xenbase;Acc:XB-GENE-481165]) HSP 1 Score: 65.0846 bits (157), Expect = 7.739e-10 Identity = 79/336 (23.51%), Postives = 145/336 (43.15%), Query Frame = 3
Query: 1524 IKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGI--------FNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSN---CKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIP 2498
I+ N++ +++++L+C ++ P E+ W+K + I FNED KSE+ ++ + + EY C++ ++K G +++ +L +Y + + E D + L C G+P I + SW S+ K KE I +S ++ + + D+G+Y C+ ++ G+ +F EV++ P++ V+ T P+N + ++ P V +SWF +D + ++ +FS I + G SS L ++ ENDFG Y C N IG S F LV ++ P
Sbjct: 195 IRVNATANMDESVVLSCD-ADGFPDPEISWLKKGEPIEDGEEKISFNED-------------------KSEMTIYRVGKDDE-AEYSCIA-NNKAGE--AEAIILLKVYAKPKITYVENKTAVELDEITLTCEA-SGDP---IPSISWRTATRNISSEEKTLDGHIVVKEHIR--MSALTLKDIQYTDAGEYICIASNAIGEDMRAMYF-EVQYAPKIKGPV--VVYTWEGNPVNITCEVLAYPSAV-VSWF-----RDGQLLPSS-------NFSNIKIYSGPSSSS--------LEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPSSP 476
BLAST of NPHS1-7 vs. Ensembl Xenopus
Match: prdx1 (peroxiredoxin 1 [Source:Xenbase;Acc:XB-GENE-481165]) HSP 1 Score: 64.6994 bits (156), Expect = 8.414e-10 Identity = 79/336 (23.51%), Postives = 145/336 (43.15%), Query Frame = 3
Query: 1524 IKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGI--------FNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSN---CKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIP 2498
I+ N++ +++++L+C ++ P E+ W+K + I FNED KSE+ ++ + + EY C++ ++K G +++ +L +Y + + E D + L C G+P I + SW S+ K KE I +S ++ + + D+G+Y C+ ++ G+ +F EV++ P++ V+ T P+N + ++ P V +SWF +D + ++ +FS I + G SS L ++ ENDFG Y C N IG S F LV ++ P
Sbjct: 219 IRVNATANMDESVVLSCD-ADGFPDPEISWLKKGEPIEDGEEKISFNED-------------------KSEMTIYRVGKDDE-AEYSCIA-NNKAGE--AEAIILLKVYAKPKITYVENKTAVELDEITLTCEA-SGDP---IPSISWRTATRNISSEEKTLDGHIVVKEHIR--MSALTLKDIQYTDAGEYICIASNAIGEDMRAMYF-EVQYAPKIKGPV--VVYTWEGNPVNITCEVLAYPSAV-VSWF-----RDGQLLPSS-------NFSNIKIYSGPSSSS--------LEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPSSP 500
BLAST of NPHS1-7 vs. Ensembl Xenopus
Match: prdx1 (peroxiredoxin 1 [Source:Xenbase;Acc:XB-GENE-481165]) HSP 1 Score: 64.6994 bits (156), Expect = 9.593e-10 Identity = 79/336 (23.51%), Postives = 145/336 (43.15%), Query Frame = 3
Query: 1524 IKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGI--------FNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSN---CKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIP 2498
I+ N++ +++++L+C ++ P E+ W+K + I FNED KSE+ ++ + + EY C++ ++K G +++ +L +Y + + E D + L C G+P I + SW S+ K KE I +S ++ + + D+G+Y C+ ++ G+ +F EV++ P++ V+ T P+N + ++ P V +SWF +D + ++ +FS I + G SS L ++ ENDFG Y C N IG S F LV ++ P
Sbjct: 233 IRVNATANMDESVVLSCD-ADGFPDPEISWLKKGEPIEDGEEKISFNED-------------------KSEMTIYRVGKDDE-AEYSCIA-NNKAGE--AEAIILLKVYAKPKITYVENKTAVELDEITLTCEA-SGDP---IPSISWRTATRNISSEEKTLDGHIVVKEHIR--MSALTLKDIQYTDAGEYICIASNAIGEDMRAMYF-EVQYAPKIKGPV--VVYTWEGNPVNITCEVLAYPSAV-VSWF-----RDGQLLPSS-------NFSNIKIYSGPSSSS--------LEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPSSP 514
BLAST of NPHS1-7 vs. Ensembl Xenopus
Match: prdx1 (peroxiredoxin 1 [Source:Xenbase;Acc:XB-GENE-481165]) HSP 1 Score: 62.7734 bits (151), Expect = 3.826e-9 Identity = 77/345 (22.32%), Postives = 148/345 (42.90%), Query Frame = 3
Query: 1524 IKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGI--------FNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSL------------SDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIP 2498
I+ N++ +++++L+C ++ P E+ W+K + I FNED KSE+ ++ + + EY C++ ++K G +++ +L +Y + + E D + L C G+P I + SW +R + ++ S + + +L S ++ + + D+G+Y C+ ++ G+ +F EV++ P++ V+ T P+N + ++ P V +SWF +D + ++ +FS I + G SS L ++ ENDFG Y C N IG S F LV ++ P
Sbjct: 192 IRVNATANMDESVVLSCD-ADGFPDPEISWLKKGEPIEDGEEKISFNED-------------------KSEMTIYRVGKDDE-AEYSCIA-NNKAGE--AEAIILLKVYAKPKITYVENKTAVELDEITLTCEA-SGDP---IPSISWRTA-TRNISSEEKASWTRPLKQETLDGHIVVKEHIRMSALTLKDIQYTDAGEYICIASNAIGEDMRAMYF-EVQYAPKIKGPV--VVYTWEGNPVNITCEVLAYPSAV-VSWF-----RDGQLLPSS-------NFSNIKIYSGPSSSS--------LEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPSSP 483
BLAST of NPHS1-7 vs. Ensembl Mouse
Match: Nphs1 (nephrosis 1, nephrin [Source:MGI Symbol;Acc:MGI:1859637]) HSP 1 Score: 70.4774 bits (171), Expect = 1.331e-11 Identity = 99/420 (23.57%), Postives = 164/420 (39.05%), Query Frame = 3
Query: 1032 EGKDFETFTEKTIILTKEDNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK--LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTV----TPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEIS 2240
E K F T E + DN L+ C I+++ F +++ +PP ++ + E + + ++ C + G NPPAT+QW KN K S+ + +A+ SV+ G ++C + Y + E+ L V F P A+ TI ++S EN+ + L C S P L+W + + D T M G +GG S L + R + C +F + T S LN+ Y P+ K++ P I+ V L C I GNP+ + +W+ +SR +++ + + + S S S + V P + K+ C S L V+F P L+ P + +N IS V +S
Sbjct: 192 EEKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIKAS-FTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCIARGG-NPPATLQWL---KNGKPVSI-------AWGTEHAQAVAHSVLVMTVRPEDHGARLSCQS-YNSVSAETQERSITLQVTFPPSAV--TILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDET------VMDGLHGGHISMSNLTLL-VKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKY-PAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPE---PSLTWLK-DSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKFSC-----KAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLS 579
BLAST of NPHS1-7 vs. Ensembl Mouse
Match: Nphs1 (nephrosis 1, nephrin [Source:MGI Symbol;Acc:MGI:1859637]) HSP 1 Score: 70.0922 bits (170), Expect = 1.583e-11 Identity = 99/420 (23.57%), Postives = 164/420 (39.05%), Query Frame = 3
Query: 1032 EGKDFETFTEKTIILTKEDNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK--LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTV----TPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEIS 2240
E K F T E + DN L+ C I+++ F +++ +PP ++ + E + + ++ C + G NPPAT+QW KN K S+ + +A+ SV+ G ++C + Y + E+ L V F P A+ TI ++S EN+ + L C S P L+W + + D T M G +GG S L + R + C +F + T S LN+ Y P+ K++ P I+ V L C I GNP+ + +W+ +SR +++ + + + S S S + V P + K+ C S L V+F P L+ P + +N IS V +S
Sbjct: 206 EEKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIKAS-FTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCIARGG-NPPATLQWL---KNGKPVSI-------AWGTEHAQAVAHSVLVMTVRPEDHGARLSCQS-YNSVSAETQERSITLQVTFPPSAV--TILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDET------VMDGLHGGHISMSNLTLL-VKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKY-PAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPE---PSLTWLK-DSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKFSC-----KAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLS 593
BLAST of NPHS1-7 vs. Ensembl Mouse
Match: Cd22 (CD22 antigen [Source:MGI Symbol;Acc:MGI:88322]) HSP 1 Score: 60.8474 bits (146), Expect = 8.008e-9 Identity = 58/266 (21.80%), Postives = 118/266 (44.36%), Query Frame = 3
Query: 1380 TSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHP---VSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPS----VKIFPSSNKIKESDYVELRCNLIQGNP---KFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLL 2147
T S + F G + C + + ++ L+V ++P ++I + P + + +N ++ +TC V+ S+P + W K + + ++++ + S+LI+H ++ + +Y+C + + G S+ L + Y P +K+ P+S +I+ V L+C+ + NP +F K + E R +SF +V+P+DSG Y C++ + G+ S + L+V + PR L
Sbjct: 216 TESKLTFQPKWTDHGKSVKCQVQHSSKVLSERTVRLDVKYTP-KLEIKVNP-TEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQM-------------SKLILHSVTKDMRG-KYRCQA-SNDIGPGESEEVELTVHYAPRDVKVLKVSPAS-EIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRY--------------------LSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRL 443
BLAST of NPHS1-7 vs. Ensembl Mouse
Match: Pxdn (peroxidasin [Source:MGI Symbol;Acc:MGI:1916925]) HSP 1 Score: 55.8398 bits (133), Expect = 3.759e-7 Identity = 72/329 (21.88%), Postives = 131/329 (39.82%), Query Frame = 3
Query: 1476 EKLLNVIFSPDAIKITIKP-NSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVE--ISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFV 2453
E L + SP I+P N+ ++ +++ L CS + HP+ ++ W + ++ D ++ G Y + ++S EY C + +S + + ++ L P + P S + E V+ +C +G+P+ +I +W S+ S + ++S+ IS V D G+Y+C ++ G S + + QPR+ F + + E V S + E I+W NKD + + G+FH S GF L+I+++ D G Y C N IG+
Sbjct: 147 EVTLRYLGSPARPTFVIQPQNTEVLVGESVTLECSAT-GHPLPQITWTRGDRTPLPID--PRVNITPSGGLY----------IQNVAQSDSG-EYTCFASNSVDSIHATAFIIVQAL--PQFTVTPQSRVVIEGQTVDFQC-AAKGHPQPVI---AWTKGGSQLSVDRRH-----LVLSSGTLRIS--GVALHDQGQYECQAVNIIG---SQKVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQLPCSSQGEPEPAITW-----NKDGVQV----------------TESGKFHIS--PEGF--LTINDVGTADAGRYECVARNTIGYA 420
BLAST of NPHS1-7 vs. Ensembl Mouse
Match: Pxdn (peroxidasin [Source:MGI Symbol;Acc:MGI:1916925]) HSP 1 Score: 55.8398 bits (133), Expect = 3.986e-7 Identity = 72/329 (21.88%), Postives = 131/329 (39.82%), Query Frame = 3
Query: 1476 EKLLNVIFSPDAIKITIKP-NSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVE--ISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFV 2453
E L + SP I+P N+ ++ +++ L CS + HP+ ++ W + ++ D ++ G Y + ++S EY C + +S + + ++ L P + P S + E V+ +C +G+P+ +I +W S+ S + ++S+ IS V D G+Y+C ++ G S + + QPR+ F + + E V S + E I+W NKD + + G+FH S GF L+I+++ D G Y C N IG+
Sbjct: 327 EVTLRYLGSPARPTFVIQPQNTEVLVGESVTLECSAT-GHPLPQITWTRGDRTPLPID--PRVNITPSGGLY----------IQNVAQSDSG-EYTCFASNSVDSIHATAFIIVQAL--PQFTVTPQSRVVIEGQTVDFQC-AAKGHPQPVI---AWTKGGSQLSVDRRH-----LVLSSGTLRIS--GVALHDQGQYECQAVNIIG---SQKVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQLPCSSQGEPEPAITW-----NKDGVQV----------------TESGKFHIS--PEGF--LTINDVGTADAGRYECVARNTIGYA 600
BLAST of NPHS1-7 vs. UniProt/SwissProt
Match: sp|O60500|NPHN_HUMAN (Nephrin OS=Homo sapiens OX=9606 GN=NPHS1 PE=1 SV=1) HSP 1 Score: 76.2554 bits (186), Expect = 1.513e-12 Identity = 127/518 (24.52%), Postives = 203/518 (39.19%), Query Frame = 3
Query: 792 YLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPENEI------GDVLSIECSSVGGFPVPNYEIYI-----------MREGKDFETFT-EKTIILTKE--DNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK---LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISW 2243
+L I D EC V +S M P VI S+ V +LL L PE G + C S P P+ I + + EG + FT E T +T DN L+ C A I+++ F ++V +PP +E + E + + ++ C + G NP AT+QW KN + S + ++ +A+ SV+ G ++C+A N++ G ++ L V F P AI I ++S EN+ + L+C S P L+W + + + T M G +GG S L R + C +F T T S +LN+ Y P+ K++ P K++ V L C I GNP+ + Y +SR T ++ + + + S S S + V Q T +G+ S L V+F P ++ P + +N +S V +SW
Sbjct: 95 HLHIEACDLSDDAEYECQV-GRSEMGPELVSPRVILSI--LVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKAS-FTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGG-NPLATLQWL---KNGQPVSTAWGTEHT-------QAVARSVLVMTVRPEDHGAQLSCEA--HNSVSAGTQEHGITLQVTFPPSAI--IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEET------VMDGLHGGHISMSNLTFL-ARREDNGLTLTCEAFSEAFTKETFKKSLILNVKY-PAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK----DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ-LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSW 580
BLAST of NPHS1-7 vs. UniProt/SwissProt
Match: sp|Q9R044|NPHN_RAT (Nephrin OS=Rattus norvegicus OX=10116 GN=Nphs1 PE=1 SV=2) HSP 1 Score: 74.7146 bits (182), Expect = 4.270e-12 Identity = 101/416 (24.28%), Postives = 160/416 (38.46%), Query Frame = 3
Query: 1050 TFTEKTIILTKEDNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK---LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTV----TPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISW 2243
T E +I DN L+ C I+++ F +++ +PP ++ + E + + ++ C T G NPPAT+QW KN K S + +A+ SV+ G ++C + N++ G ++ L V F P A ITI + S EN+ + L C S P L+W + + D T M G +GG S L R + C +F + T S LN+ Y P+ K++ P I+ V L C I GNP + W F +SR + ++ + + + S S S + V P + K+ C S L V+F P L+ P + +N IS V +SW
Sbjct: 212 TEAEARVIPQSSDNGQLLVCEGSNPALDTPIKAS-FTMNILFPPGPPVIDWPGLNEGHVRAGENLELPC-TARGGNPPATLQWL---KNGKPVS-------TAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSY--NSVSAGTQERSITLQVTFPPSA--ITILGSVSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDET------VMDGLHGGHISMSNLTFL-VRREDNGLPLTCEAFSDAFSKETFKKSLTLNVKY-PAQKLWIEGPPEGQYIRTGTRVRLVCLAIGGNPD---PSLIW-FKDSRPVSEPRQPQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNRAKFSC-----KAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSW 594
BLAST of NPHS1-7 vs. UniProt/SwissProt
Match: sp|Q9QZS7|NPHN_MOUSE (Nephrin OS=Mus musculus OX=10090 GN=Nphs1 PE=1 SV=2) HSP 1 Score: 70.0922 bits (170), Expect = 1.107e-10 Identity = 99/420 (23.57%), Postives = 164/420 (39.05%), Query Frame = 3
Query: 1032 EGKDFETFTEKTIILTKEDNNLLMKCRALQAGTHNFIESNVFMIHVFYPPDG--LEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEK--LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSK-TGVTISDSFVLNILYNPSVKIF----PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEI----ISNSLSDISFQTV----TPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEIS 2240
E K F T E + DN L+ C I+++ F +++ +PP ++ + E + + ++ C + G NPPAT+QW KN K S+ + +A+ SV+ G ++C + Y + E+ L V F P A+ TI ++S EN+ + L C S P L+W + + D T M G +GG S L + R + C +F + T S LN+ Y P+ K++ P I+ V L C I GNP+ + +W+ +SR +++ + + + S S S + V P + K+ C S L V+F P L+ P + +N IS V +S
Sbjct: 206 EEKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIKAS-FTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCIARGG-NPPATLQWL---KNGKPVSI-------AWGTEHAQAVAHSVLVMTVRPEDHGARLSCQS-YNSVSAETQERSITLQVTFPPSAV--TILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDET------VMDGLHGGHISMSNLTLL-VKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKY-PAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPE---PSLTWLK-DSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKFSC-----KAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLS 593
BLAST of NPHS1-7 vs. UniProt/SwissProt
Match: sp|Q9N1E3|CD22_PONPY (B-cell receptor CD22 (Fragment) OS=Pongo pygmaeus OX=9600 GN=CD22 PE=2 SV=1) HSP 1 Score: 60.8474 bits (146), Expect = 2.846e-8 Identity = 66/228 (28.95%), Postives = 106/228 (46.49%), Query Frame = 3
Query: 1485 LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSES---HPVSELKW----VKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTIS-DSFVLNILYNPSVKIF--PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQP 2138
LNV P I + P I E+Q + LTC ++ S +P+ +L+W V + + N SL T + F +SEL + + S + + H G +S D+ LN+ + P +KI PS ++E D V + C + NPK+ SW+ K+ + K+ N+L ++ Q VT SGKY C +++ G G S E FL+V++ P
Sbjct: 132 LNVSERPFPPHIQLPPE--IQESQEVTLTCLLNFSCYGYPI-QLQWFLEGVPVGQAAVNS-----TSLATKSVF-----TRSELKF--SPQWSHHGKIVTCQLHGADGKFLSNDTVQLNVKHTPKLKIEVNPSDAIVREGDSVTMTCEVSSSNPKYT--TVSWL----------KDGTPLKK--QNALM-LTLQEVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP 329
BLAST of NPHS1-7 vs. UniProt/SwissProt
Match: sp|P36335|NCA12_XENLA (Neural cell adhesion molecule 1-B OS=Xenopus laevis OX=8355 GN=ncam1-b PE=2 SV=1) HSP 1 Score: 62.003 bits (149), Expect = 3.054e-8 Identity = 73/336 (21.73%), Postives = 147/336 (43.75%), Query Frame = 3
Query: 1524 IKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGI--------FNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNS---LSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIP 2498
I+ N++ +++++L+C ++ P E+ W+K + I FNED KSE+ ++ + + EY C++ +++ G +++ VL +Y + + E D + L C G+P I + +W + ++ ++E + I+ +S ++ + + D+G+Y C+ ++ G +F EV++ P++ V+ T P+N ++ P +SWF +D + ++ +FS I + +N F++L ++ ENDFG Y C N IG S F LV ++ P
Sbjct: 216 IRVNATANMDESVVLSCD-ADGFPDPEISWLKKGEPIEDGEEKISFNED-------------------KSEMTIYRVEKEDE-AEYSCIA-NNQAGE--AEAIVLLKVYAKPKMTYVENKTTVELDEITLTCEA-SGDP---IPSITWRT--AHRNISSEEKTLDGHIVVKDHIRMSALTLKDIQYTDAGEYFCVASNPIGVDMQAMYF-EVQYAPKIRGPV--VVYTWEGNPVNITCDVLAHPSAA-VSWF-----RDGQLLPSS-------NFSNIKI--------YNGPTFSSLEVNPDSENDFGNYNCSAVNSIGHESSEFILVQADTPSSP 497
BLAST of NPHS1-7 vs. TrEMBL
Match: A0A0H3YKM4 (NPHS1-7 OS=Schmidtea mediterranea OX=79327 GN=NPHS1-7 PE=2 SV=1) HSP 1 Score: 319.316 bits (817), Expect = 6.590e-88 Identity = 250/903 (27.69%), Postives = 422/903 (46.73%), Query Frame = 3
Query: 342 GETRDLYCVINKPVVVGDVFLICPLSPGLCLINCRGSNEYTKAIDCKTEQQSHETIFHYKIKFFEKHQGKWICQFRDWLSEPLAFRVKRNLSIESLTYYPNPIISGNNLTLTCSAIXXXXXXXXXXXXIIETST-NKTSHFDGIATDDWSAYLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPENEIGDVLSIECSSVGGFPVPNYEIYIMREGKDFETFTEKTIILTKEDNNLLMKCRALQ-AGTHNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMDKNYK--NHSLHXXXXXXXXXXXXGEAIT-SSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKN-YSWMFCESRKS-TFAKENSNCKEIISN--SLSDI-SFQ--------TVTPKDSGKYQCLITDVSGKGFSGEF-FLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIW-------NNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCEIQFSNSCQDIQIPHPSTGNVISPVLANIENYSFYLSVFQNSELKYKTESIRSFKNLNIRNSVTINFTIII-VVLCCFGILILV-LGISAFMIRKYKRQAKKTTLFNGNSF---NEHLCQEKQLL 2957
G +DL+C I + L+CPL+ GLC+ +C + K I C + S + +F YK K F+ +G+W CQ+ S L+ +V I+SL P P G L +TC + + + F+ I++ T ++ D +S + I + L +C+V+ +S + + + I+ PS++ + + EIG ++S +CSS G P P +Y R GK + +ILTK DN C + +G + SN MI V YPP+ +E+ P +E++ + C +K S P + I+WT D + HS F+ + G T S V + +G I C IY+ + EK + V+F+P+ I + P I E +++ LTC S+P S ++W + G ED+T+H++ M Y G + S L +H T+R YKC+ H+ IS + LN+LY P +++F E ++V+L+C GNP I ++ + W FC S + E+ EI N L D+ SF PKD G Y C + G + EF FL V F P L + I V++ S PK EI WF+ +++ S ++ N + ++ +D S RF + N L+IS I D+G Y C++SN G F + N I + +I + + NKA + + PP +GH++H+ L +C IQ S +C ++QI +P++G+ + + Y++ L V S++ T I+ ++++ + V ++ ++I V++ GIL+L+ + + ++ K +R+ K NS N H ++ +L
Sbjct: 41 GTEQDLFCSIETEEQTHRMLLLCPLTVGLCMTDCIEN----KDISCNRKTISGQIVFQYKFKVFKTFEGEWKCQYGGQSSRSLSLKVSDKPFIKSLAMTPKPAWKGKQLNITCQVMPMTGITGIFIQRILDDGTVENIANAIPYKVDQYSEGITIKAAEPDLHNKVQCIVHTESEISTAKILETNIYYFPSQLILTSSNPLKQYEIGSLISFQCSSDNGNPRPVVSLYKKRFGKKPQKQVSANVILTKYDNKAEFFCLMEKISGKSPNLTSNTIMILVHYPPEKIELNEEPVDNQLESQSKQFTCSSKGNSEPLSQIEWTLFDAYGRLVAHSETFKILERVKKANPGALNTLESTVKMTLIRKYNGFKIKCSIIYQGLNMLNQEKQIKVVFAPNHISLIPDPQGGIPETRSVNLTCFTGSSNPSSNIQWFRTEPGKRPEDITSHSNKDMMPSNYSGIAIHSSLNIHGTNRQDHGTIYKCIVSHAYMNSEISKEYFLNVLYPPVIQLFSLPKIPNEGNFVQLQCQTSGGNPSIISQSQFQWKFCPVITSYEYKYEDQPNTEIRQNCYQLPDMFSFHHHHIFNITAAAPKDRGWYSCQCENAG--GVTVEFMFLNVYFSPILKHQTSSRVYVKSGSNIVLQVKWSSYPKIHEIKWFIKPNSRISARLYEPDHQAQNINEMKKRIDLS----PNSRFKLTI-VNSTIQLNISSITAYDYGDYFCEVSNSRGQSSIEFQIFPTNDISISESNIRLQFNANKATVYFDPPTIGHFTHMSLRVCLIQSSGTCSEMQINNPNSGHATISLPQSPSLYNYRLIVHNGSKVLQMTNIIQ--RDISSPHWVEMSLEMMIAVIIGVVGILVLLFVALMTLILLKCRRKKPKDNYLENNSVATTNSHQRRQDYML 930
BLAST of NPHS1-7 vs. TrEMBL
Match: A0A504YN65 (Uncharacterized protein OS=Fasciola gigantica OX=46835 GN=FGIG_01852 PE=4 SV=1) HSP 1 Score: 172.17 bits (435), Expect = 2.357e-39 Identity = 202/913 (22.12%), Postives = 351/913 (38.44%), Query Frame = 3
Query: 396 VFLICPLSPGLCLINCRGSNEYTKAIDCKT-EQQSHET------------IFHYKI-KFFEKHQGKWICQFRDWLSEPLAFRVKRNLSIESLTYYPNPIISGNNLTLTCSAIXXXXXXXXXXXXIIETSTNKTSHFDGIA-------------------------TDDWSAYLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPENE----IGDVLSIECSSVGGFPVPNYEIYIMREGKDFETFTEKTII------------------LTKEDNNLLMKCRALQAGTHNFIE----SNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXC-FTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGE---AITSSVVDFIANKNQSGIIINCDAIYKNN-IIPGPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKI-NKGIFNE---------------DVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSW----------MFCESRKS--------------------------TFAKENSNCKEIISNSLSDISFQ-------TVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSL-----SIWNNEK----------------FERILDFSTIIVSEGRFHSSF------------------------NENGFTT--LSISEIVENDFGLYVCKISNEIGFVYSYFWLV--SENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCE 2600
VFL+CPLS G+CL +C+ I C+ E QS T Y+I + +H G W+CQ + SE +V IESLT NP+ +G+ + LTC+ ET+ + F+GI D +++ L + + + EC + A ++I L +H P ++I+ + P +E G I C++ P P + + R G+ E T + LT++DN C + TH +E S+ +V YPP + + + P + E+ C SGSNPP+ + WT +D L ++ + GE I SV+ +A ++ +G C AIY+ + E++L V F+P+ + +T P + E+Q + LTC+ S HP + ++W ++ N G E ++T A + T G +GG ++ S+L V +T R Q ++CL H + L +LY V++ + V L C GNP I Y+W +F +S + T A + ++ + N L +S Q V G Y C + G S +FL++ +QP++ + ++ E + F + + P E WF ++ ++ S+ + +N + ++ + D+ + + R + F E G T LS +E+ DFG YVC++ +++G F L+ SE ++P S+ V + ++PP +S ++L +C
Sbjct: 32 VFLLCPLSTGVCLEDCK-PTPNVHNITCEELEPQSARTGSDRSSMTRASRRIRYQIPQVTGRHNGTWVCQNKGVSSERHELKVSDAPYIESLTASRNPVAAGSTVRLTCTVAPTPTAYELLRQRSWETNRLRQFKFEGIQFAWHRLRSKVDTGERSSPILNRVEQPDAFTSSLEVHDLRYEEGTVFECTAEDSRGRRAVRQIQLDVHYTPKSIHIETI---PSHERPVQAGTRCHILCTAESSNPAPTFNLLRRRVGQSQAYLMEDTALDGASLGTGNVARQAFAFQLTEQDNGASFFCEVI---THGVMETVARSDGRQFNVTYPPQSIFVTMDPVGSVAESVSKVFTCQLNASGSNPPSELTWTQLDSAGALIPLKDDIHVQSTDQIVGEFGALIARSVLTVVARRSINGRRFECTAIYQGKKTMLRAEEILEVKFAPNNVGLTALPMDGVRESQRLDLTCATSSCHPPATIRWFEVPNHGSLEEEEGSWTIGTDPMKPNELTDLAQMDTKPGKFGGTEVSSKLTVTKTYRLHQGTVFRCLVEHPAMEKPVISEHRLQVLYPTVVQLISHPPEPVVGQTVLLSCQTSGGNP-LIGFTYTWFAADRFQLAGLFADSANNDSNRIEDASKSSMTATSSVRATGGVETRAAKRADGAPALKNMLRLLSQQEAYLNLTKVRLSQRGWYACQVASAGGVSHS-TYFLDLFYQPQIDRRTRSRVQAHVGESVAFKLFIDANPPWAEAIWFQLNTDEQSIHPSLPTPLSNGRGSDTYFVGYHHNPYMGYDELYDYGMELKRKRRLVTGFGGKTRTQVGSDNSDRSNIVAGKGSGEKGNLTFILSFNEVRSEDFGDYVCQLRHKLGVQEFPFQLLRKSEAEGILP-SSVVVQKRGPTTVVRFRPPGNLRFSRLVLRVCR 934
BLAST of NPHS1-7 vs. TrEMBL
Match: A0A4E0RP05 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_000418 PE=4 SV=1) HSP 1 Score: 167.933 bits (424), Expect = 4.653e-38 Identity = 199/910 (21.87%), Postives = 347/910 (38.13%), Query Frame = 3
Query: 396 VFLICPLSPGLCLINCRGSNEYTKAIDCKT-EQQSHET------------IFHYKI-KFFEKHQGKWICQFRDWLSEPLAFRVKRNLSIESLTYYPNPIISGNNLTLTCSAIXXXXXXXXXXXXIIETSTNKTSHFDGIA-------------------------TDDWSAYLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPEN-EIGDVLSIECSSVGGFPVPNYEIYIMREGKDFETFTEKTII------------------LTKEDNNLLMKCRALQAGTHNFIE----SNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXC-FTKSGSNPPATIQWTFMDKNYKNHSLHXXXXXXXXXXXXGE---AITSSVVDFIANKNQSGIIINCDAIYKNN-IIPGPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKI-NKGIFNE---------------DVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSW----------MFCESRKS--------------------------TFAKENSNCKEIISNSLSDISFQ-------TVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSL-----SIWNNEK----------------FERILDFSTIIVSEGRFHSSF------------------------NENGFTT--LSISEIVENDFGLYVCKISNEIGFVYSYFWLV--SENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCE 2600
VFL+CPLS G+CL +C+ I C+ E QS T Y+I + +H G W+CQ + SE +V IESLT NP+ +G+ + LTC ET+ + F+GI D +++ L + + + EC + A ++I L +H P ++I+ + + G I C++ P P + + R G+ E T LT++DN C + TH +E S+ +V YPP + + + P + E+ C SGSNPP+ + WT +D L ++ + GE I SV+ +A ++ +G C AIY+ + E++L V F+P+ + +T P + E+Q + LTC+ S HP + ++W ++ N G E ++T A + T G +GG ++ S+L V +T R Q ++CL H + L +LY V++ + V L C GNP + Y+W +F +S + T A + ++ + N L +S Q V G Y C + G S +FL++ +QP++ + ++ E + F + + P E WF ++ ++ S+ + +N + ++ + D+ + + R + F E G T LS +E+ DFG YVC++ +++G F L+ SE ++P S+ V + ++PP +S ++L +C
Sbjct: 32 VFLLCPLSTGVCLEDCK-PTPNVHNITCEELEPQSARTGSDRSSMTRASRRIRYQIPQVTGRHNGTWVCQNKGVSSERHELKVSDAPYIESLTANRNPVAAGSTVRLTCIVAPTPTAYELLRQRSRETNRLRQFKFEGIQFAWHRLRSKVDTGARRSPIVNRVEQPDAFTSSLEVHDLRYEEGTVFECTAEDSRGRRAVRQIQLDVHYTPKSIHIETIPAHDRPVQAGTRCHILCTAESSNPAPTFNLLRRRVGQSQAYLMEDTAFDGPSLGNENVARQAFAFQLTEQDNGASFFCEVI---THGVMETVARSDGRQFNVTYPPQSIFVTMDPVGSVAESVSKVFTCQLNASGSNPPSELTWTQLDSAGALIPLKDDIHVQSTDQIVGEFGALIARSVLTVVARRSINGRRFECTAIYQGKKTMLRAEEILEVKFAPNNVGLTALPMDGVRESQRLDLTCATSSCHPPATIRWFEVPNHGSLEEEEGSWTIGTDPTKPNELTDLAQMDTKPGKFGGTEVSSKLTVTKTYRLHQGTVFRCLVEHPAMEKPVISEHRLQVLYPTVVQLISHPPEPVVGQTVLLSCQTSGGNP-LVGFTYTWFAADRFQLAGLFADSANNDSNRIQDASKSSMTATSSVRATGGVETRAAKRADGAPALKNMLRLLSQQEAYLNLTKVRLSQRGWYACQVASAGGVSHS-TYFLDLFYQPQIDRRTRSRVQAHVGESVAFKLFIDANPPWAEAIWFQLNTDEQSIHPSLPTPLSNGRGSDTYFVGYHHNPYMGYDELYDYGMELKRKRRLVTGFGGKTRTQVGSDNSDRSNIIAGKGSGEQGNLTFILSFNEVRSEDFGDYVCQLRHKLGVQEFPFQLLRKSEVEGILP-SSVVVQKRGPTTVVRFRPPGNLRFSRLVLRVCR 934
BLAST of NPHS1-7 vs. TrEMBL
Match: G7Y8F2 (Cell adhesion molecule 2 OS=Clonorchis sinensis OX=79923 GN=CLF_102725 PE=4 SV=1) HSP 1 Score: 139.813 bits (351), Expect = 1.582e-29 Identity = 146/599 (24.37%), Postives = 250/599 (41.74%), Query Frame = 3
Query: 1068 IILTKEDNNLLMKCRALQAGTHN-FIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXC-FTKSGSNPPATIQWTFMDKNYKNHSLHXX--XXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIP-GPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKIN-KGIFNEDVTAH----ASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIF--PSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAK----------------ENSNCKEIIS------NSL-------------------SDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWN--------------------------------NEKFERILD--FSTIIVSEG---RFH---SSFNENGFT-TLSISEIVENDFGLYVCKISNEIGFVYSYFWLVS--ENSCVIPQESITVLLDKNKAAITYQPPKVGHYS 2576
+++T +DN + C AGT + S ++V YPP+G+ + P + E+ K C +GSNPP+ IQW +D + + + + G + S + A ++ +G C AIY P E++L V+F+P+ +++T KP + E+ + LTC S HP + ++W ++ K F+ T A + T G YGG + S L+V +T RS Q+ ++C H I + + +LY P+V++ P ++++ V L C GNP+ ++SW F SR S FA+ +N N +E+ + N L S ++F V G Y C ++ SG FFL++ +QP L K+ + E ++F+ + P VE++WF +++ S + N +LD S I V G + H +E+ T +L + +DFG Y+C+ + +G YF L E +IP SI + + + Y+PP+ Y+
Sbjct: 115 LVMTDQDNRAELFCGVNGAGTDTTLVRSTGVRMNVTYPPNGVHVTASPAGPVTESVAKKFTCKLNSTGSNPPSDIQWMQLDSAGARLPMADVEITPTEQMSSPTGGYLAHSTLTVNARRSSNGRRFECAAIYLQKRTPLRSEEILEVLFAPNNVRLTEKPMGGVRESDRLELTCKTSSCHPPAVIRWFEVPPKAKFSNQATNELTDLAQIDTSPGEYGGISVSSTLVVSKTYRSQQHTVFRCQVEHPGLEKPIINEHQMQVLYPPTVQLLTVPEEPVVRQT--VTLSCQTSGGNPQDGF-SFSW-FAGSR-SQFAELLDGNHDNTASNKKPAKNDN-RELTTQQRKEFNQLSKSSPPELDKMVSMTVFQDSQLNFTNVGLSQRGWYACEVSS-SGGAAHASFFLDLFYQPILDRRTKQQVAAHLGETVSFIAHLEANPPSVEVTWFQLNNVAQSSAPSGYPRHYETFYASGYPYHGYDGFYEYRVRRASGLNRTIRSLLDQGQSRIQVGNGMGEKHHIVAEKSDEDNLTFSLRFMGVQTSDFGGYLCQARHRLGVKEFYFQLTKKPETDGIIP-SSINITQRGSITIVRYKPPEKPPYT 705
BLAST of NPHS1-7 vs. TrEMBL
Match: A0A4S2LUT7 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_004718 PE=4 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 1.565e-27 Identity = 135/594 (22.73%), Postives = 239/594 (40.24%), Query Frame = 3
Query: 1068 IILTKEDNNLLMKCRALQAGTHN-FIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXC-FTKSGSNPPATIQWTFMDKNYKNHSLHXX--XXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIP-GPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKI-NKGIFNEDVTAH----ASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSW------MFCESRKSTFAKENSNCKEIISNSL--------------------------------SDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWN--------------------------------NEKFERILD--FSTIIVSEG---RFH---SSFNENGFT-TLSISEIVENDFGLYVCKISNEIGFVYSYFWLVS--ENSCVIPQESITVLLDKNKAAITYQPPKVGHYS 2576
+++T +DN + C +AGT + S +++ YPP+G+ + P + E+ K C +GSNPP+ I W +D + + + + G ++ S + A ++ +G C AIY P E++L V+F+P+ +++T KP + E+ + LTC S HP + ++W ++ K F+ T A + T YGG + S L+V +T RS Q+ ++C H I + L +LY P+V++ + V L C GNP+ ++SW F E SN K + +++ S ++F V G Y C ++ G + FFL++ +QP L K+ + E ++F+ + P VE++WF +++ S + N +LD S I V G + H +E+ T +L + +DFG Y+C+ + +G YF L + +IP SI + + + Y+PP+ Y+
Sbjct: 97 LVMTDQDNRAELFCGVNRAGTDTTLVRSTGVRMNITYPPNGVHVTASPAGPVTESVAKKFTCKLNSTGSNPPSDIHWMQLDSAGAQLPMTDVEITPTEQMSSPNGGYLSHSTLTVNARRSSNGRRFECAAIYLQKRTPLRSEEILEVLFAPNNVRLTEKPMGGVRESDRLELTCKTSSCHPPAVIRWFEVPPKPKFSNQATNELTDLAQIDTSPAEYGGTSVSSILVVSKTYRSQQHTVFRCQVEHPGLEKPIINEHRLQVLYPPTVQLLIVPEEPVVGQTVTLSCQTSGGNPQDGF-SFSWFAGSHSQFAELLDGNHDNTASNKKPVKNDNREPTIQQRKEFNQLSKSSPPEIDKMVSMTVFQDSQLNFTNVGLSQRGWYACEVSSSGGTAHA-SFFLDLFYQPILDRRTKQQVPAHLGETVSFIAHMEANPPSVEVTWFQLNNVVQSSAPSGYPRHYETFYASGYPYHGYDGFYEYRVRRASALNRTIRSLLDQGQSRIQVGNGMGEKHHIVAEKSDEDNLTFSLRFMGVQTSDFGAYLCQARHRLGVKEFYFQLTKKPDTDGIIP-SSINITQRGSTTIVRYKPPEKPPYT 687
BLAST of NPHS1-7 vs. Ensembl Cavefish
Match: ENSAMXT00000036142.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001677.1:18159:21331:1 gene:ENSAMXG00000038439.1 transcript:ENSAMXT00000036142.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 58.5362 bits (140), Expect = 3.300e-9 Identity = 60/204 (29.41%), Postives = 97/204 (47.55%), Query Frame = 3
Query: 1479 KLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLIT 2081
K L ++ P ++ ++I P+ I+E ++ LTCS S+ +P E W K + + A+ KT T +++ S S + EYKC S + K G SD+ LN+LY P SV I P S +I E V L C+ GNP ++ Y+W F K + + ++ + + I+ + DSG+YQ + T
Sbjct: 14 KTLTILNPPKSVSVSISPSGEIVEGSSVTLTCS-SDGNPPVEYTWYKGSSSV--------ATGKTFT-------------LNKIS-SVNSGEYKCRSSN-KHGEKYSDTVTLNVLYPPKSVSVSISP-SGEIVEGSSVTLTCSS-DGNPP--VQKYTW---------FKKVDKDVQQKWTGQIYSIT--NIRSADSGEYQLMET 178
BLAST of NPHS1-7 vs. Ensembl Cavefish
Match: si:dkey-33i11.1 (B-cell receptor CD22 [Source:NCBI gene;Acc:103028527]) HSP 1 Score: 58.9214 bits (141), Expect = 2.615e-8 Identity = 48/160 (30.00%), Postives = 75/160 (46.88%), Query Frame = 3
Query: 1482 LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQ---QLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSW 1943
L+NV +SP K+ I P IME ++ LTC + + PV + W K+ GGQ + S+ + + + RS + +Y C S++ GV S S L++LY P SV PS+ I+ + L C+ Q NP ++NY+W
Sbjct: 307 LVNVTYSPKNTKVLISPRGDIMEGYSVNLTCISNANPPVEKYSWYKVG---------------------GGQPWARGSSQNLTYSSVRSHHSGQYYCTSWNV-IGVGTSPSVTLSVLYAPKNTSVLARPST-VIETGASLTLTCS-SQANPA--VENYTW 440
BLAST of NPHS1-7 vs. Ensembl Cavefish
Match: ENSAMXT00000050572.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001677.1:18993:21625:1 gene:ENSAMXG00000029721.1 transcript:ENSAMXT00000050572.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 53.5286 bits (127), Expect = 2.242e-7 Identity = 59/221 (26.70%), Postives = 98/221 (44.34%), Query Frame = 3
Query: 1485 LNVIF--SPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEF 2132
+N IF P ++ ++I P+ I+E ++ LTCS + PV + W K ++DV Q+ ++ RS+ + EY+C++ +++ G S+ L +L+ P SV I P S KI E V L C+ GNP Y+W S +T K N +S + +SG+Y+C ++ G+ +S L V F
Sbjct: 4 INDIFLDPPKSVSVSISPSGKIVEGSSVTLTCSSDGNPPVQKYTWFK----KVDKDVQ--------------QKWTGQIYSITNIRSADSGEYQCMATNTQ-GSQSSEYKSLTVLHPPKSVSVSISP-SGKIVEGSSVTLTCSS-DGNPPV---EYTWYKGSSSVAT-------GKTFTLNKISSV--------NSGEYKCRSSNKHGEKYSDTVTLNVLF 185
BLAST of NPHS1-7 vs. Ensembl Cavefish
Match: ENSAMXT00000001412.2 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001731.1:57675:66251:-1 gene:ENSAMXG00000001390.2 transcript:ENSAMXT00000001412.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 51.6026 bits (122), Expect = 5.724e-7 Identity = 41/156 (26.28%), Postives = 71/156 (45.51%), Query Frame = 3
Query: 1476 EKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSW 1943
E+L + P ++ ++I P+ I+E ++ LTCS + PV W K N+DV Q+ ++ RS+ + EY+C++ +++ G S+ L +L PS +I E V L C+ GNP ++NY+W
Sbjct: 20 ERLELITHPPKSVSVSISPSGEIVEGSSVTLTCSSDGNPPVQNYTWFK----KVNKDVP--------------QKWTGQIYSITNIRSADSGEYQCMATNTQ-GSRSSEYKTLTVLRTPSGEIV-------EGSSVTLTCSS-DGNPP--VQNYTW 146
BLAST of NPHS1-7 vs. Ensembl Cavefish
Match: ENSAMXT00000047510.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001731.1:157159:160856:1 gene:ENSAMXG00000034132.1 transcript:ENSAMXT00000047510.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 52.7582 bits (125), Expect = 1.164e-6 Identity = 38/131 (29.01%), Postives = 64/131 (48.85%), Query Frame = 3
Query: 1473 PEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKI-NKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPS 1853
PE LNV + P +I ++I P+ I+E ++ LTCS + PV + W K +KG+ Q+ ++ + RS+ + EY+C++ +++ G S+ L +LY P SV I PS
Sbjct: 193 PEVTLNVRYPPKSISVSISPSGEIVEGSSVTLTCSSDGNPPVQKYTWFKKGDKGV-------------------QQKFTGQIYSIKNIRSADSGEYQCMATNTQ-GSQSSEYKSLTVLYPPKRISVSISPS 303
BLAST of NPHS1-7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004392.1 (pep scaffold:Pmarinus_7.0:GL476636:579022:606187:1 gene:ENSPMAG00000003992.1 transcript:ENSPMAT00000004392.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 50.0618 bits (118), Expect = 1.746e-6 Identity = 70/329 (21.28%), Postives = 128/329 (38.91%), Query Frame = 3
Query: 1521 TIKPNSSIMENQTIILTCSVSESHPVSELKW------VKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNK----IKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKG------FSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYS 2459
T+ P S +T+ L C +++S+P + +W +K NK SL+ GG L++ + R ++CL+ + + G S L + + FPS + ++ + + L CN P Y W+ E + E + +S ++ V D+G+Y CL+ G+ FS LE+ ++S ++ LP E + + K + + F + + S+S W K R+ D + + VS L ++++ D G+YVC +N +G V S
Sbjct: 19 TLYPEDS--PEKTVTLRC-LAKSNPPATYRWRHNGTEIKWNK---------RYSLE------GGN-----LVISDLDRDQDASTFQCLATN-RFGTLASKQATLKFAH---LDRFPSEERGPLRVRLQNSLVLLCNPPSHYPDV---EYQWLLNEFPELVPQDE----RRFVSQQTGNLYIARVEASDAGRYACLLRSTLGRHSPNVNIFSAFAALEIRRDSPMMSLLPRIEVKLPAETV------VLKGDNLRLECFALGNPVPSIS-WQ-RKDGRLPDRTRLSVSAA------------VLEVADVTHEDEGVYVCNATNALGSVLS 293
BLAST of NPHS1-7 vs. Ensembl Nematostella
Match: EDO49557 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGM1]) HSP 1 Score: 50.8322 bits (120), Expect = 3.084e-6 Identity = 70/321 (21.81%), Postives = 128/321 (39.88%), Query Frame = 3
Query: 1584 ESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKG---FSGEFFLEVEFQPRLLSTFKKVIKTLPKE--------PINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWL-VSENSCVIPQESI 2510
E P ++W+K ++ + ++ +H + Y L + E ++S + + ++ +G D V + N S F S+ E V L I G P + SW ++ + N + + + ++ + TP DSG Y+C +T+ +GK FS E +E E +P ++ K L +E + Q KP+ + WF KD + + +E I ++E E+G +L I E + D G Y ++SNE G F + V + IP++++
Sbjct: 193 EGKPKPSVEWLKDDRPVLSD---SHIKMTEEDDIYS-------LTIREPTKSDEGMYTVKITNDVGSGTRTFDVKVEDTTTNDSFVPFEST----EEGNVRLSVK-ITGKP---VPEVSW----TKDEKPVHKIQNIRLDHQDDIYTLTIREATPNDSGSYKCTLTNDAGKSTRTFSVE--IEGETKPEKGKPTEREGKPLEEEELPVSAETEVEMTAQVTGKPQP-SVEWF-----KDDVPVSPDEH---------ITITE--------EDGTYSLVIKEPTKKDEGTYTVEVSNEAGLGRRTFDVSVDDTRKTIPKDAV 466
BLAST of NPHS1-7 vs. Ensembl Medaka
Match: mag (myelin associated glycoprotein [Source:NCBI gene;Acc:101159465]) HSP 1 Score: 63.1586 bits (152), Expect = 1.310e-9 Identity = 68/298 (22.82%), Postives = 127/298 (42.62%), Query Frame = 3
Query: 1374 AITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKL--LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDN 2261
A+ SS + F+ +G ++ C Y N + E+L L++ ++P ++ + + +S +ME ++ L C V +S+P + W +F E + ++ F ++E I Y C+ + ++ S L++ Y P + S + E + L C+ QGNP + T+ K+ I ++ LS + VTP+ G+Y+CL + G+ S F + VE+ P LL K T+ +E + V P+ + I ++L N
Sbjct: 196 AVMSSTLAFVPRPMHNGQLLGCRVYYPNTTLVY-ERLISLDIKYAPRSVWVNV--SSEVMEGSSVTLHCEV-DSNPPPRISW------MFGEQELLWDTASNVSLFLDDVTPQNEGI------------YTCVGDNGFG--AMNTSMYLSVRYPPREPVVNESMTVLEGSSLALHCS-TQGNPAPTL-------------TWLKDGELVGTITADELSVLEVIEVTPQGDGQYRCLAENEHGRA-SSSFNITVEYAPVLLEESK---CTVVREGVQCVCMATGNPEPI-IEFYLADLN 450
BLAST of NPHS1-7 vs. Ensembl Medaka
Match: mag (myelin associated glycoprotein [Source:NCBI gene;Acc:101159465]) HSP 1 Score: 62.7734 bits (151), Expect = 1.597e-9 Identity = 68/298 (22.82%), Postives = 127/298 (42.62%), Query Frame = 3
Query: 1374 AITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKL--LNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDN 2261
A+ SS + F+ +G ++ C Y N + E+L L++ ++P ++ + + +S +ME ++ L C V +S+P + W +F E + ++ F ++E I Y C+ + ++ S L++ Y P + S + E + L C+ QGNP + T+ K+ I ++ LS + VTP+ G+Y+CL + G+ S F + VE+ P LL K T+ +E + V P+ + I ++L N
Sbjct: 196 AVMSSTLAFVPRPMHNGQLLGCRVYYPNTTLVY-ERLISLDIKYAPRSVWVNV--SSEVMEGSSVTLHCEV-DSNPPPRISW------MFGEQELLWDTASNVSLFLDDVTPQNEGI------------YTCVGDNGFG--AMNTSMYLSVRYPPREPVVNESMTVLEGSSLALHCS-TQGNPAPTL-------------TWLKDGELVGTITADELSVLEVIEVTPQGDGQYRCLAENEHGRA-SSSFNITVEYAPVLLEESK---CTVVREGVQCVCMATGNPEPI-IEFYLADLN 450
BLAST of NPHS1-7 vs. Ensembl Medaka
Match: ENSORLT00000038552.1 (B-cell receptor CD22-like [Source:NCBI gene;Acc:105356876]) HSP 1 Score: 62.3882 bits (150), Expect = 2.386e-9 Identity = 57/233 (24.46%), Postives = 105/233 (45.06%), Query Frame = 3
Query: 1494 IFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRL----LSTFKKVIK 2171
+++P ++ +++ + IME ++ LTCS +++P ++ +W K N+ + +D + LI+ RS +Y C++ +K G SD +N+ Y P SV + PS+ ++ E V L C+ NP NY+W K+N + S + F ++ + SG Y C + G+ S L+V++ PR+ +S F K+ K
Sbjct: 246 VYAPKSVSVSMS-LTEIMEGSSVTLTCSC-DANPAAKFRWYKNNQPLLRKDQS--------------------LILRSVQRSDSR-KYHCVA-ENKLGEAASDYVFINVEYPPETSSVSVSPSA-EVLEGSSVTLTCS-SDANP---AANYTWF----------KDNRPLR-----SEDKVHFSSIRSEHSGNYSCKSENKHGQSSSTPLLLDVQYPPRIPSVSVSVFGKISK 434 HSP 2 Score: 51.9878 bits (123), Expect = 3.448e-6 Identity = 54/222 (24.32%), Postives = 95/222 (42.79%), Query Frame = 3
Query: 1482 LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP-----SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISN-SLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVE 2129
+NV + P+ +++ P++ ++E ++ LTCS S+++P + W K N+ + +ED +S+ RS + Y C S +K G + S +L++ Y P SV +F KI + V L C+ NP N+SW + K+ ++ K N ++SD + SG Y C + G+ S +E E
Sbjct: 327 FINVEYPPETSSVSVSPSAEVLEGSSVTLTCS-SDANPAANYTWFKDNRPLRSEDKVHFSSI----------------------RSEHSGNYSCKS-ENKHGQSSSTPLLLDVQYPPRIPSVSVSVF---GKISKGSSVTLTCS-SDANP---AANFSW---------YKKDENSPKASGPNWTISDFRAE-----HSGFYYCEAENRRGRLNSSLHLIEAE 503
BLAST of NPHS1-7 vs. Ensembl Medaka
Match: ENSORLT00000046542.1 (B-cell receptor CD22-like [Source:NCBI gene;Acc:105356876]) HSP 1 Score: 62.3882 bits (150), Expect = 2.430e-9 Identity = 57/233 (24.46%), Postives = 105/233 (45.06%), Query Frame = 3
Query: 1494 IFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRL----LSTFKKVIK 2171
+++P ++ +++ + IME ++ LTCS +++P ++ +W K N+ + +D + LI+ RS +Y C++ +K G SD +N+ Y P SV + PS+ ++ E V L C+ NP NY+W K+N + S + F ++ + SG Y C + G+ S L+V++ PR+ +S F K+ K
Sbjct: 279 VYAPKSVSVSMS-LTEIMEGSSVTLTCSC-DANPAAKFRWYKNNQPLLRKDQS--------------------LILRSVQRSDSR-KYHCVA-ENKLGEAASDYVFINVEYPPETSSVSVSPSA-EVLEGSSVTLTCS-SDANP---AANYTWF----------KDNRPLR-----SEDKVHFSSIRSEHSGNYSCKSENKHGQSSSTPLLLDVQYPPRIPSVSVSVFGKISK 467 HSP 2 Score: 51.9878 bits (123), Expect = 3.477e-6 Identity = 54/222 (24.32%), Postives = 95/222 (42.79%), Query Frame = 3
Query: 1482 LLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP-----SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISN-SLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVE 2129
+NV + P+ +++ P++ ++E ++ LTCS S+++P + W K N+ + +ED +S+ RS + Y C S +K G + S +L++ Y P SV +F KI + V L C+ NP N+SW + K+ ++ K N ++SD + SG Y C + G+ S +E E
Sbjct: 360 FINVEYPPETSSVSVSPSAEVLEGSSVTLTCS-SDANPAANYTWFKDNRPLRSEDKVHFSSI----------------------RSEHSGNYSCKS-ENKHGQSSSTPLLLDVQYPPRIPSVSVSVF---GKISKGSSVTLTCS-SDANP---AANFSW---------YKKDENSPKASGPNWTISDFRAE-----HSGFYYCEAENRRGRLNSSLHLIEAE 536
BLAST of NPHS1-7 vs. Ensembl Medaka
Match: ENSORLT00000031495.1 (B-cell receptor CD22-like [Source:NCBI gene;Acc:105356876]) HSP 1 Score: 61.6178 bits (148), Expect = 3.340e-9 Identity = 55/225 (24.44%), Postives = 101/225 (44.89%), Query Frame = 3
Query: 1494 IFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNP---SVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKNYSWMFCESRKSTFAKENSNCKEIISNSLSDISFQTVTPKDSGKYQCLITDVSGKGFSGEFFLEVEFQPRLLSTFK 2159
+++P ++ +++ + IME ++ LTCS +++P ++ +W K N+ + +D + LI+ RS +Y C++ +K G SD +N+ Y P SV + PS+ ++ E V L C+ NP NY+W K+N + S + F ++ + SG Y C + G+ S L+V++ PR+ S K
Sbjct: 279 VYAPKSVSVSMS-LTEIMEGSSVTLTCSC-DANPAAKFRWYKNNQPLLRKDQS--------------------LILRSVQRSDSR-KYHCVA-ENKLGEAASDYVFINVEYPPETSSVSVSPSA-EVLEGSSVTLTCS-SDANP---AANYTWF----------KDNRPLR-----SEDKVHFSSIRSEHSGNYSCKSENKHGQSSSTPLLLDVQYPPRIPSVSK 459
BLAST of NPHS1-7 vs. Planmine SMEST
Match: SMESG000035985.1 (SMESG000035985.1) HSP 1 Score: 670.233 bits (1728), Expect = 0.000e+0 Identity = 360/407 (88.45%), Postives = 363/407 (89.19%), Query Frame = 3
Query: 2130 FQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCEIQFSNSCQDIQIPHPSTGNVISPVLANIENYSFYLSVFQNSELKYKTESIRSFKNLNIRNSVTINFTIIIVVLCCFGILILVLGISAFMIRKYKRQAKKTTLFNGNSFNEHLCQEKQLLHLRNRSGLLXXXXXXXXXXXXXXXXXXXXXYQMNFVPHEYPVSDSKSHVYMNMTPKGHSLDGFSNKSSNMETIKSQETSFTCLSNLSPSKSQKLLTMSDINKFNHYENCDSYQNKMLLNGLYNDEIYNFPE 3350
FQPRLLSTFKKVIKTLPKEPINFVVQFISKPK+VEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCEIQFSNSCQDIQIPHPSTGNVISPVLANIENYSFYLSVFQNSELKYKTESIRSF KKTTLFNGNSFNEHLCQEKQLL+LRNRSGLLQSTSSMLSPPKSQSSLLSQNSYQMNFVPHEYPVSDSKSHVYMNMTPKGHSLDGFSNKSSNMET+KSQETSFTCLSNLSPSKSQKLLTMSDINKFNHYENCDSYQNKMLLNGLYNDEIYNFPE
Sbjct: 113 FQPRLLSTFKKVIKTLPKEPINFVVQFISKPKEVEISWFLISDNKDSLSIWNNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCEIQFSNSCQDIQIPHPSTGNVISPVLANIENYSFYLSVFQNSELKYKTESIRSF--------------------------------------------KKTTLFNGNSFNEHLCQEKQLLNLRNRSGLLQSTSSMLSPPKSQSSLLSQNSYQMNFVPHEYPVSDSKSHVYMNMTPKGHSLDGFSNKSSNMETLKSQETSFTCLSNLSPSKSQKLLTMSDINKFNHYENCDSYQNKMLLNGLYNDEIYNFPE 475
BLAST of NPHS1-7 vs. Planmine SMEST
Match: SMESG000016267.1 (SMESG000016267.1) HSP 1 Score: 318.931 bits (816), Expect = 2.572e-91 Identity = 247/903 (27.35%), Postives = 417/903 (46.18%), Query Frame = 3
Query: 342 GETRDLYCVINKPVVVGDVFLICPLSPGLCLINCRGSNEYTKAIDCKTEQQSHETIFHYKIKFFEKHQGKWICQFRDWLSEPLAFRVKRNLSIESLTYYPNPIISGNNLTLTCSAIXXXXXXXXXXXXIIETST-NKTSHFDGIATDDWSAYLFISQVDWRLSVTAECLVYEKSNMIAFQRIPLVIHSLPSKVNIQLLGLKPENEIGDVLSIECSSVGGFPVPNYEIYIMREGKDFETFTEKTIILTKEDNNLLMKCRALQ-AGTHNFIESNVFMIHVFYPPDGLEMQXXXXXXXXXXXXXXXXCFTKSGSNPPATIQWTFMD---KNYKNHSLHXXXXXXXXXXXXGEAITSSVVDFIANKNQSGIIINCDAIYKNNIIPGPEKLLNVIFSPDAIKITIKPNSSIMENQTIILTCSVSESHPVSELKWVKINKGIFNEDVTAHASLKTMTGFYGGQQLKSELIVHETSRSSQNVEYKCLSFHSKTGVTISDSFVLNILYNPSVKIFPSSNKIKESDYVELRCNLIQGNPKFIIKN-YSWMFCESRKS-TFAKENSNCKEIISN--SLSDI-SFQ--------TVTPKDSGKYQCLITDVSGKGFSGEF-FLEVEFQPRLLSTFKKVIKTLPKEPINFVVQFISKPKKVEISWFLISDNKDSLSIW-------NNEKFERILDFSTIIVSEGRFHSSFNENGFTTLSISEIVENDFGLYVCKISNEIGFVYSYFWLVSENSCVIPQESITVLLDKNKAAITYQPPKVGHYSHVLLTMCEIQFSNSCQDIQIPHPSTGNVISPVLANIENYSFYLSVFQNSELKYKTESIRSFKNLNIRNSVTINFTIII-VVLCCFGILILV-LGISAFMIRKYKRQAKKTTLFNGNSF---NEHLCQEKQLL 2957
G +DL+C I + L+CPL+ GLC+ +C + K I C + S + +F YK K F+ +G+W CQ+ S L+ +V I+SL P P G L +TC + + + F+ I++ T ++ D +S + I + L +C+V+ +S + + + I+ PS++ + + EIG ++S +CSS G P P +Y R GK + +ILTK DN C + +G + SN MI V YPP+ +E+ P +E++ C +K S P + I+WT D + N + S V + +G I C IY+ + EK + V+F+P+ I + P I E +++ LTC S+P S ++W + G ED+T+H++ M Y G + S L +H T+R YKC+ H+ IS + LN+LY P +++F E ++V+L+C GNP I ++ + W FC S + E+ EI N L D+ SF V PKD G Y C + G + EF FL V F P L + I V++ S PK EI WF+ +++ S ++ N + ++ +D S RF + N L+IS I D+G Y C++SN G F + N I + +I + + NKA + + PP +GH++H+ L +C IQ S +C ++QI +P++G+ + + Y++ L V S++ T I+ ++++ + V ++ ++I V++ GIL+L+ + + ++ K +R+ K NS N H ++ +L
Sbjct: 41 GTEQDLFCSIETEEQTHRMLLLCPLTVGLCMTDCIEN----KDISCNRKTISGQIVFQYKFKVFKTFEGEWKCQYGGQSSRSLSLKVSDKPFIKSLAMTPKPAWKGKQLNITCQVMPMTGITGIFIQRILDDGTVENIANAIPYKVDQYSEGITIKAAEPDLHNKVQCIVHTESEISTAKILETNIYYFPSQLILTSSNPLKQYEIGSLISFQCSSDNGNPRPVVSLYKKRFGKKPQKQVSANVILTKYDNKAEFFCLMEKISGKSPNLTSNTIMILVHYPPEKIELNEEPVDNQLESQSKHFTCSSKGNSEPLSQIEWTLFDAYGRLVANSETFKILERVKKANPGALNTLESTVKMTLIRKYNGFKIKCSIIYQGLNMLNQEKQIKVVFAPNHISLIPDPQGGIPETRSVNLTCFTGSSNPSSNIQWFRTEPGKRPEDITSHSNKDMMPSNYSGIAIHSSLNIHGTNRQDHGTIYKCIVSHAYMNSEISKEYFLNVLYPPVIQLFSLPKIPNEGNFVQLQCQTSGGNPSIISQSQFQWKFCPVITSYEYKYEDQPNTEIRQNCYQLPDMFSFHHHHIFNITAVAPKDRGWYSCQCENAG--GVTVEFMFLNVYFSPILKHQTSSRVYVKSGSNIVLQVKWSSYPKIHEIKWFIKPNSRISARLYEPDHQAQNINEMKKRIDLS----PNSRFKLTI-VNSTIQLNISSITAYDYGDYFCEVSNSRGQSSIEFQIFPTNDISISESNIRLQFNANKATVYFDPPTIGHFTHMSLRVCLIQSSGTCSEMQINNPNSGHATISLPQSPSLYNYRLIVHNGSKVLQMTNIIQ--RDISSPHWVEMSLEMMIAVIIGVVGILVLLFVALMTLILLKCRRKKPKDNYLENNSVATTNSHQRRQDYML 930
BLAST of NPHS1-7 vs. Planmine SMEST
Match: SMESG000035985.1 (SMESG000035985.1) HSP 1 Score: 166.007 bits (419), Expect = 4.914e-48 Identity = 80/81 (98.77%), Postives = 81/81 (100.00%), Query Frame = 3
Query: 3108 MNMTPKGHSLDGFSNKSSNMETIKSQETSFTCLSNLSPSKSQKLLTMSDINKFNHYENCDSYQNKMLLNGLYNDEIYNFPE 3350
MNMTPKGHSLDGFSNKSSNMET+KSQETSFTCLSNLSPSKSQKLLTMSDINKFNHYENCDSYQNKMLLNGLYNDEIYNFPE
Sbjct: 1 MNMTPKGHSLDGFSNKSSNMETLKSQETSFTCLSNLSPSKSQKLLTMSDINKFNHYENCDSYQNKMLLNGLYNDEIYNFPE 81 The following BLAST results are available for this feature:
BLAST of NPHS1-7 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of NPHS1-7 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of NPHS1-7 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of NPHS1-7 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of NPHS1-7 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of NPHS1-7 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of NPHS1-7 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of NPHS1-7 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of NPHS1-7 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of NPHS1-7 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of NPHS1-7 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of NPHS1-7 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of NPHS1-7 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of NPHS1-7 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035538 ID=SMED30035538|Name=NPHS1-7|organism=Schmidtea mediterranea sexual|type=transcript|length=3431bpback to top protein sequence of SMED30035538-orf-1 >SMED30035538-orf-1 ID=SMED30035538-orf-1|Name=SMED30035538-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1075bp MEQKIFCCVFDISCTQIQRIIYQCLTCAFLWFYLFETVHSHKNIKLQVKEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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