Sepiapterin reductase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035504 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Sepiapterin reductase vs. Ensembl Human
Match: SPR (sepiapterin reductase [Source:HGNC Symbol;Acc:HGNC:11257]) HSP 1 Score: 139.043 bits (349), Expect = 1.257e-38 Identity = 83/276 (30.07%), Postives = 151/276 (54.71%), Query Frame = 3 Query: 93 ELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 E + + + +TGA RGFGR+ A + S+L++ RN+ L + + + + +RV DL + ++ +L + +L + + ++I+NAG++GD+SK + + + ++ +N+T + + + +LK S + + +VN+SSLCA+QPF+ ++YCA KA R+M FQ LA+E P++ V+NY+PGP+DT+M + + ++ ++ LK GKL++ SA+KL L +KSG+ +DFYD Sbjct: 2 EGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAG--LQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRT-------VVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEE------PNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLS--LLEKDEFKSGAHVDFYD 260
BLAST of Sepiapterin reductase vs. Ensembl Human
Match: DHRS7B (dehydrogenase/reductase 7B [Source:HGNC Symbol;Acc:HGNC:24547]) HSP 1 Score: 52.373 bits (124), Expect = 4.249e-7 Identity = 66/245 (26.94%), Postives = 111/245 (45.31%), Query Frame = 3 Query: 102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVE-TMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAAS-----DELTSQMR 800 ++ ++ ITGA G G+ CA V F+ + L++CGRN L E L+ E T + +V+ K L T + +I+ ++ +CF ++++NAG G + + + +++RV+E+ N G V + LL + + R+ + +V +SS+ S Y A K + FF CL E E Q ++ VI SPG + T + I S D T+Q R Sbjct: 50 LRNAVVVITGATSGLGKECAKV---FYAAGAKLVLCGRNGGALEE--LIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEI----LQCFGYVDILVNNAGISYRGTIMDTTVD-VDKRVMET----NYFGPVALTKALLPSM---IKRRQGH------IVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME--QYEIEVTVI--SPGYIHTNLSVNAITADGSRYGVMDTTTAQGR 267
BLAST of Sepiapterin reductase vs. Ensembl Human
Match: DHRS7B (dehydrogenase/reductase 7B [Source:HGNC Symbol;Acc:HGNC:24547]) HSP 1 Score: 51.9878 bits (123), Expect = 4.856e-7 Identity = 66/245 (26.94%), Postives = 111/245 (45.31%), Query Frame = 3 Query: 102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVE-TMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAAS-----DELTSQMR 800 ++ ++ ITGA G G+ CA V F+ + L++CGRN L E L+ E T + +V+ K L T + +I+ ++ +CF ++++NAG G + + + +++RV+E+ N G V + LL + + R+ + +V +SS+ S Y A K + FF CL E E Q ++ VI SPG + T + I S D T+Q R Sbjct: 35 LRNAVVVITGATSGLGKECAKV---FYAAGAKLVLCGRNGGALEE--LIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEI----LQCFGYVDILVNNAGISYRGTIMDTTVD-VDKRVMET----NYFGPVALTKALLPSM---IKRRQGH------IVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME--QYEIEVTVI--SPGYIHTNLSVNAITADGSRYGVMDTTTAQGR 252
BLAST of Sepiapterin reductase vs. Ensembl Celegans
Match: dhs-21 (L-xylulose reductase [Source:UniProtKB/Swiss-Prot;Acc:Q21929]) HSP 1 Score: 55.4546 bits (132), Expect = 1.066e-8 Identity = 49/205 (23.90%), Postives = 96/205 (46.83%), Query Frame = 3 Query: 78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGD--LSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAK 686 M Y+ K+ I +TGA +G G+ L K + +I RNE LL L+ ET + +R + + + +++E+ + KL F +++NAG + + + + + ++R + + ++ N + ++I+ S +VN+SS AI+P ++ ++YCA KA +M +CLA E ++ Sbjct: 1 MPANYDFTDKR--ILVTGASQGIGKEICLSLAKA---GAQVIAFARNEANLLS--LVKETTS--LRYTIIPIVGDVSANEEV------LFKLIVPHFPIHGLVNNAGIATNHAIGQITQQSIDRTFAVNVRGPILIAQLVARNFVDRQIKGS-------------IVNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQ 177
BLAST of Sepiapterin reductase vs. Ensembl Celegans
Match: Y47G6A.21 (pep chromosome:WBcel235:I:3551949:3559807:-1 gene:WBGene00021646.1 transcript:Y47G6A.21.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y47G6A.21) HSP 1 Score: 48.1358 bits (113), Expect = 2.722e-6 Identity = 47/188 (25.00%), Postives = 81/188 (43.09%), Query Frame = 3 Query: 120 FITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEW 677 ITGA G G+ AL+ F + + L + GRN L E L + A+ ++ +E S + K+I+D ++ + +I++AG G + E V + N+N+ + + L I + +VNVSS+ PF ++ YC K+ + F +CLA+E Sbjct: 5 IITGASSGIGKGTALL---FAKKKYQLSLTGRNTDSLKEVAALCISEGAISADDILITAVELSSDEAPKAIVDATVQKFG---RIDSLINSAGILRAGPVLDSGIE-----VYDELMNVNVRSLIRLTRAALPHIITTKGT----------VVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEM 171
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: Sptr (gene:FBgn0014032 transcript:FBtr0071241) HSP 1 Score: 134.806 bits (338), Expect = 2.461e-37 Identity = 86/272 (31.62%), Postives = 144/272 (52.94%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENE-SLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 ++ + +TGA RG GR A K + E S++ + GRN+ L E+K + + V+ + L+LET +++ IL+ + FE ++IHNAG VGD SK + E + ++ + + N+ + +N ++ V K K L+VN+S+L AI P SM+ YC +KA REM+F+ LA E A+ D V+NY+PG +DT+M + A + + R +E+ ++ P + E+ F VL + +KSG +D+ D Sbjct: 5 QRTYLLVTGASRGIGREFAQQLAKRIKAEGSMVTLLGRNQTLLQESKAEIVATVPDLSVQTYSLELETAKTEDFTKILEA--SGGKNNFERAIVIHNAGTVGDTSKRAKEIGDTDFLQRYYHSNVFSAISLNCEFMR-------VFKGIPK---LVVNLSTLAAIAPISSMAHYCTVKAAREMYFRVLATEESAE----DTLVLNYAPGVIDTQMTVQVQREAHDPAVVAMFREQRESKTMLTPAQTTER-FIKVLEAF-KFKSGDHVDYRD 258
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG12116 (gene:FBgn0030041 transcript:FBtr0071240) HSP 1 Score: 62.3882 bits (150), Expect = 8.493e-11 Identity = 67/278 (24.10%), Postives = 128/278 (46.04%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKL--LETKLLVETMNALIRVEVFKLDLETVSSDEI--KSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDN--AASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 ++ + ++G+ G+S AL + SL +I ++ +L LE L E ++V + KLD + + ++ ++++D + + Q FE +I+HN G + E +++ + V +N L+ +H V K L VNV+S ++P + C+ K R+M+F+ +A E + R + V+++SPG MDT ++ +L + ++L+ I P + KL N+L S + SG +D+YD Sbjct: 10 RRTFLVLSGSSNPLGQSLALEFCRRLATGSLALILDEDQEQLRELENHLRSELKTENVKVTIGKLDKDHSNGVQLMEQALMDNFMADKDNQRFERSIILHNEGKAA--THMLLEPQSDDDWKAYVQQQLYAPVALNQTWLQS-KHLERVEK-------LAVNVTSSLMVRPLVHAGLLCSCKRARDMYFRAMAAE---EYRF-GVHVLSFSPGLMDTHEGQCDVNGNRITPADLIATKQLLQL--PRIKPCQATLKLI-NILEEIS-FVSGHDVDYYD 269
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG31549 (gene:FBgn0051549 transcript:FBtr0078707) HSP 1 Score: 58.5362 bits (140), Expect = 1.180e-9 Identity = 62/229 (27.07%), Postives = 99/229 (43.23%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQ-RL----PDLFVIN-YSPGPMDTEMMAYLIDN 767 K +I +TGA G G S A+ K LL+I GRNE KL ET + + A +L + E++ I+ L + V+++NAG G + S E +R N N+ + + E+ + K N +VNVSS+C ++ F + Y KA + F C+A+E K R+ P + V + + G MD E A +++ Sbjct: 5 KDKVIIVTGASSGIGASAAVHLAKL---GGLLVIVGRNEEKLKET---ADNIVAAGGATPLELQADMTKEAEVQQIVGATLAKHG---RIDVLVNNAGILETGSIEATSLEQFDR-----LMNTNVRSLYQLTMLATPELVKT----KGN------IVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTDIHKRGGMDEETYAKFLEH 209
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG31549 (gene:FBgn0051549 transcript:FBtr0335215) HSP 1 Score: 58.5362 bits (140), Expect = 1.180e-9 Identity = 62/229 (27.07%), Postives = 99/229 (43.23%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQ-RL----PDLFVIN-YSPGPMDTEMMAYLIDN 767 K +I +TGA G G S A+ K LL+I GRNE KL ET + + A +L + E++ I+ L + V+++NAG G + S E +R N N+ + + E+ + K N +VNVSS+C ++ F + Y KA + F C+A+E K R+ P + V + + G MD E A +++ Sbjct: 5 KDKVIIVTGASSGIGASAAVHLAKL---GGLLVIVGRNEEKLKET---ADNIVAAGGATPLELQADMTKEAEVQQIVGATLAKHG---RIDVLVNNAGILETGSIEATSLEQFDR-----LMNTNVRSLYQLTMLATPELVKT----KGN------IVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTDIHKRGGMDEETYAKFLEH 209
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG12171 (gene:FBgn0037354 transcript:FBtr0078708) HSP 1 Score: 50.8322 bits (120), Expect = 5.038e-7 Identity = 56/216 (25.93%), Postives = 96/216 (44.44%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEM 746 K +I +TGA G G +++ K LL I GRN KL ET E + A ++ + S +++ I+ L + V+++NAG +G + S E +R N N+ + +++ E+ + K N +VNVSS+ I+ F + Y KA + F +C+A+E K + V + +PG + TE+ Sbjct: 5 KDKVIIVTGASSGIGAGTSVLLAKL---GGLLTIVGRNLDKLNET---AEQIVAAGGAPALQVAADINSESDVQGIVSATLAKHG---RIDVLVNNAGILELGSIENTSLEQFDR-----VMNTNVRSLYQLTHLVTPELIKT----KGN------IVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPK----GVRVNSVNPGVIITEL 192
BLAST of Sepiapterin reductase vs. Ensembl Zebrafish
Match: spra (sepiapterin reductase a [Source:ZFIN;Acc:ZDB-GENE-050522-412]) HSP 1 Score: 139.043 bits (349), Expect = 8.985e-39 Identity = 85/271 (31.37%), Postives = 144/271 (53.14%), Query Frame = 3 Query: 108 KNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920 K L+ ITGA RGFGR+ AL S+L++ R+E +LLE K + + V +DL + E K I + + + + ++ HNA ++GD+S+ +F + S+ ++N++ + + +L+ + + + ++VN+SSLCA++PF + YC+ KA R+M F+ LA E P+L V+NY+PGP+DT+M + A EL + + NG+L+ D S +KL +L + Y SG +D+YDL Sbjct: 9 KALVIITGASRGFGRALALSVAARVSPGSVLVLAARSEEQLLELKSALTRGETGLTVRCVPVDLGCEAGVE-KLIAET--RDIQPDIQHLLLFHNAASLGDVSRYCRDFTNMEELNSYLSLNVSSALCLTAGVLRTYPKRSGLTR-------VIVNISSLCALRPFPTWVQYCSGKAARDMMFRVLAEEE------PELRVLNYAPGPLDTDMQREARSSCADSELRNTFSQMHANGQLLTCDQSIQKLMSVLLED--KYSSGEHLDYYDL 261
BLAST of Sepiapterin reductase vs. Ensembl Zebrafish
Match: sprb (sepiapterin reductase b [Source:ZFIN;Acc:ZDB-GENE-070719-1]) HSP 1 Score: 129.798 bits (325), Expect = 3.276e-35 Identity = 76/276 (27.54%), Postives = 149/276 (53.99%), Query Frame = 3 Query: 102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNAL---IRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920 + + + +TGA +G+GR+ AL + S+L++ R +L + K + +++A ++++V + + D ++ + + T E +II+NA ++GD+S+C+ F + + + +N++G + + +L+ + +R+ +VN+SSLCA++PF S +YC KA R+M F+ LA E PDL V++Y+PGP+DT+M + + EL + +G+L++ + S KL +L + Y SG+ +D+Y+L Sbjct: 12 LGRAVCVVTGASKGYGRTLALQISCLLKPRSVLLLVSRTADQLNQLKQDIVSLHAAHTDLQLDVRCVQADLQEPDGVQKTIQETRNTLSTDIEHLLIINNAASLGDVSRCAVSFTDPCEVSRYLALNVSGVLSLTAGILQAFPPAVGLRRT-------VVNISSLCALKPFPSWVLYCTGKAARDMMFRVLAEEE------PDLRVLSYAPGPLDTDMQLQARCFSGNVELRRSFSSMFSDGQLLSCEESGAKLMKILLDD--QYPSGAHLDYYEL 272
BLAST of Sepiapterin reductase vs. Ensembl Xenopus
Match: dock8 (dedicator of cytokinesis 8 [Source:Xenbase;Acc:XB-GENE-987088]) HSP 1 Score: 104.375 bits (259), Expect = 1.257e-26 Identity = 60/174 (34.48%), Postives = 98/174 (56.32%), Query Frame = 3 Query: 396 GNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 G++GD+SK +F + + + + N++ + + LLK ++++ ++VNVSSL A+QPF+S ++YC+ KA R+M F+ LA E + D+ V+NY+PGP+DT+M A EL + KE GK+++ SA+K+ L YKSG IDF+D Sbjct: 1 GSIGDVSKMFVDFSDPKEVTDYMMFNVSSPLCLTASLLKTFPRRPDLQR-------VVVNVSSLAALQPFKSWALYCSGKAARDMIFRVLAEEEK------DVRVLNYAPGPLDTDMHVVARTQTADQELRRFLMDRKEKGKMVDIQVSAKKMLD--LLEADAYKSGDHIDFFD 159
BLAST of Sepiapterin reductase vs. Ensembl Xenopus
Match: gria4 (glutamate receptor, ionotropic, AMPA 4 [Source:Xenbase;Acc:XB-GENE-5838893]) HSP 1 Score: 53.9138 bits (128), Expect = 1.255e-7 Identity = 58/234 (24.79%), Postives = 106/234 (45.30%), Query Frame = 3 Query: 87 TYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERR--VIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDE 782 T E K+ N++++TGA G G + K L++ R E +LL K +++L ++ L L+ + K +K L+ + ++++NAG S+ S F+E V + +N GT+ + +L+ H E ++ +VN+SS+ + S Y A K + FF L E A PD+ + N PGP+ ++ +++NA ++E Sbjct: 43 TPESKLGGNVVWVTGASSGIGEELSYQLAKI---GCPLVLSSRRETELLRVKQKCLEISSLEDQDILILPLDMTQTSMHKEATEKALQHFG---RIDILVNNAGR----SQRSL-FVETNLDVFRALIELNYLGTISITKHVLQ---HMIERKQGK------IVNISSVVGLIGAPLSSGYSASKHALQGFFNSLRTELTA---YPDIIISNICPGPVQSK----IVENALTEE 249
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Spr (sepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078]) HSP 1 Score: 132.494 bits (332), Expect = 2.683e-36 Identity = 78/266 (29.32%), Postives = 142/266 (53.38%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 +TGA RGFGR+ A + S++++ R+E L + K + ++V + DL T + ++ +L + +L + + ++I+NA +GD+SK + + ++ +N+T + + + L + S + K +VN+SSLCA+QP++ +YCA KA R+M +Q LA E P + V++Y+PGP+D +M + + EL S+++ LK +G L++ SA+KL L ++SG+ +DFYD Sbjct: 13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT-------VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 261
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Spr (sepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078]) HSP 1 Score: 132.494 bits (332), Expect = 2.683e-36 Identity = 78/266 (29.32%), Postives = 142/266 (53.38%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 +TGA RGFGR+ A + S++++ R+E L + K + ++V + DL T + ++ +L + +L + + ++I+NA +GD+SK + + ++ +N+T + + + L + S + K +VN+SSLCA+QP++ +YCA KA R+M +Q LA E P + V++Y+PGP+D +M + + EL S+++ LK +G L++ SA+KL L ++SG+ +DFYD Sbjct: 13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT-------VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 261
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Spr (sepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078]) HSP 1 Score: 98.2117 bits (243), Expect = 7.180e-24 Identity = 68/266 (25.56%), Postives = 120/266 (45.11%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 +TGA RGFGR+ A + S++++ R+E L + K + ++V + DL T + ++ +L + +L + + ++I+NA +GD+SK F N+N +P++ +YCA KA R+M +Q LA E P + V++Y+PGP+D +M + + EL S+++ LK +G L++ SA+KL L ++SG+ +DFYD Sbjct: 13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSK------------GFLNVNDL--------------------------------------AEPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 218
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Dhrs7b (dehydrogenase/reductase (SDR family) member 7B [Source:MGI Symbol;Acc:MGI:2384931]) HSP 1 Score: 53.1434 bits (126), Expect = 1.583e-7 Identity = 69/255 (27.06%), Postives = 110/255 (43.14%), Query Frame = 3 Query: 81 SKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMM--AYLIDNA---ASDELTSQMRILKE 812 SK Y ++ ++ +TGA G GR CA V F + L++CGRN + L E + + + F + + I + +IL +CF V+I+NAG G +S + ++R+V+E IN G V + LL + E ++ + +V +SS+ S Y A K + FF CL E E ++ V SPG + T + A D + A D+ T+Q R E Sbjct: 31 SKAY---LRNAVVVVTGATSGLGRECAKV---FHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFVVTFDLADPGTIAAAAAEIL-------QCFGYVDVLINNAGISYRGTISDTIVD-VDRKVME----INYFGPVALTKALLPSM---VERKQGH------IVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEMEEA----NIKVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAAE 254
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Dhrs7b (dehydrogenase/reductase (SDR family) member 7B [Source:MGI Symbol;Acc:MGI:2384931]) HSP 1 Score: 53.1434 bits (126), Expect = 1.743e-7 Identity = 69/255 (27.06%), Postives = 110/255 (43.14%), Query Frame = 3 Query: 81 SKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMM--AYLIDNA---ASDELTSQMRILKE 812 SK Y ++ ++ +TGA G GR CA V F + L++CGRN + L E + + + F + + I + +IL +CF V+I+NAG G +S + ++R+V+E IN G V + LL + E ++ + +V +SS+ S Y A K + FF CL E E ++ V SPG + T + A D + A D+ T+Q R E Sbjct: 46 SKAY---LRNAVVVVTGATSGLGRECAKV---FHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFVVTFDLADPGTIAAAAAEIL-------QCFGYVDVLINNAGISYRGTISDTIVD-VDRKVME----INYFGPVALTKALLPSM---VERKQGH------IVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEMEEA----NIKVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAAE 269
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|Q17QK8|SPRE_BOVIN (Sepiapterin reductase OS=Bos taurus OX=9913 GN=SPR PE=2 SV=1) HSP 1 Score: 140.198 bits (352), Expect = 2.082e-38 Identity = 86/275 (31.27%), Postives = 149/275 (54.18%), Query Frame = 3 Query: 102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKL--LETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 + + L +TGA RGFGR+ A V S+L++ RN+ L LET+L E +R+ DL + ++ ++ + L + + ++I+NAG +GD+SK + + + ++ +N+T T+ + + +L+ S + + +VN+SS+CA+QPF+ +YCA KA R M FQ LA E P + V++Y PGP+DT+M + + +L ++ LK G+L++ SA+KL ++L N ++SG+ IDFYD Sbjct: 11 LGRTLCVLTGASRGFGRTLAQVLAPLMSPRSVLVLSARNDEALRQLETELGAEWPG--LRIVRVPADLGAETG--LQQLVGALCDLPRPEGLQRVLLINNAGTLGDVSKRWVDLTDPTEVNNYWTLNLTSTLCLTSSILQAFPDSPGLSRT-------VVNISSICALQPFKGWGLYCAGKAARNMMFQVLAAE------EPSVRVLSYGPGPLDTDMQQLARETSVDPDLRKSLQELKRKGELVDCKISAQKLL-SLLQN-DKFESGAHIDFYD 266
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|P35270|SPRE_HUMAN (Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1) HSP 1 Score: 139.043 bits (349), Expect = 6.037e-38 Identity = 83/276 (30.07%), Postives = 151/276 (54.71%), Query Frame = 3 Query: 93 ELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 E + + + +TGA RGFGR+ A + S+L++ RN+ L + + + + +RV DL + ++ +L + +L + + ++I+NAG++GD+SK + + + ++ +N+T + + + +LK S + + +VN+SSLCA+QPF+ ++YCA KA R+M FQ LA+E P++ V+NY+PGP+DT+M + + ++ ++ LK GKL++ SA+KL L +KSG+ +DFYD Sbjct: 2 EGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAG--LQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRT-------VVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEE------PNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLS--LLEKDEFKSGAHVDFYD 260
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|P18297|SPRE_RAT (Sepiapterin reductase OS=Rattus norvegicus OX=10116 GN=Spr PE=1 SV=1) HSP 1 Score: 136.346 bits (342), Expect = 5.469e-37 Identity = 83/267 (31.09%), Postives = 143/267 (53.56%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920 +TGA RGFGR+ A S+L++ R++ L + K + T ++V + DL T S ++ +L + +L + + ++I+NAG +GD+SK + + ++ +N+T + + L +S + K +VN+SSLCA+QPF+ +YCA KA R+M +Q LAVE P + V++Y+PGP+DT M + + EL S+++ L G+L++ SA+KL L ++SG+ +DFYD+ Sbjct: 13 LTGASRGFGRALAPQLAGLLSPGSVLLLSARSDSMLRQLKEELCTQQPGLQVVLAAADLGTESG--VQQLLSAVRELPRPERLQRLLLINNAGTLGDVSKGFLNINDLAEVNNYWALNLTSMLCLTTGTLNAFSNSPGLSKT-------VVNISSLCALQPFKGWGLYCAGKAARDMLYQVLAVEE------PSVRVLSYAPGPLDTNMQQLARETSMDPELRSRLQKLNSEGELVDCGTSAQKLLS--LLQRDTFQSGAHVDFYDI 262
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|Q8R536|SPRE_MERUN (Sepiapterin reductase OS=Meriones unguiculatus OX=10047 GN=SPR PE=2 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 7.988e-36 Identity = 80/266 (30.08%), Postives = 141/266 (53.01%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 +TGA RGFGR+ A + S+L++C R++ L + + +RV DL T + ++ +L + +L + + + ++I+NAG +GD+SK + + ++ +N+T + + + L S + K +VN+SSLCA+QPF+ +YC KA R+M Q LA E P + V++Y+PGP+DT+M + + EL ++++ LK G+L++ SA+KL L ++SG+ +DFYD Sbjct: 13 LTGASRGFGRALAPRLAQLLAPGSVLLLCARSDSALRRLEEELGAQQPGLRVVRAAADLGTEAG--LRQVLRAVRELPKPEGLQRLLLINNAGTLGDVSKGVLNVNDPAEVNNYWALNLTSMLCLTSGTLNAFPDSPGLSKT-------VVNISSLCALQPFKGWGLYCTGKAARDMLCQVLAAEE------PSVRVLSYAPGPLDTDMQQLARETSMDPELRNRLQRLKSEGELVDCGTSAQKLLN--LLQKDTFQSGAHVDFYD 261
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|Q64105|SPRE_MOUSE (Sepiapterin reductase OS=Mus musculus OX=10090 GN=Spr PE=1 SV=1) HSP 1 Score: 132.494 bits (332), Expect = 1.647e-35 Identity = 78/266 (29.32%), Postives = 142/266 (53.38%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 +TGA RGFGR+ A + S++++ R+E L + K + ++V + DL T + ++ +L + +L + + ++I+NA +GD+SK + + ++ +N+T + + + L + S + K +VN+SSLCA+QP++ +YCA KA R+M +Q LA E P + V++Y+PGP+D +M + + EL S+++ LK +G L++ SA+KL L ++SG+ +DFYD Sbjct: 13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT-------VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 261
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A0K8UBL0 (Sepiapterin reductase OS=Bactrocera latifrons OX=174628 GN=SPR PE=4 SV=1) HSP 1 Score: 155.992 bits (393), Expect = 6.253e-42 Identity = 87/272 (31.99%), Postives = 152/272 (55.88%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYE-TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 K+ +F+TGA RG G+ ++ + S++++ R+E+ LL TK +E + ++V + DL V++ +++ +L+K LK + + FE IIHNAG VGD+SK + + + V + +N+ + +N + + +V +VN++S CAI+PF SMS YC+ KA REM+F+ LA E Q L ++ V+NY+PG +DTEM + + + EL + ++N ++ P+ + K F VL +K+G +D+YD Sbjct: 7 KRTYLFVTGASRGIGQRMSIEVAAKLKPGSIIVLLARSEQGLLNTKESIEALGNDLKVYTYSTDLSLVTATQLRELLEKSLKGVKISDFERAFIIHNAGTVGDVSKSAVDVSDANVWHQYYYVNVFSVISLNCEFFRVFSGTPKV----------VVNITSKCAIEPFASMSFYCSGKAAREMYFRVLATE----QALDNVVVLNYAPGAIDTEMTEQVQRESTNKELVGLFKKQRDNKTMLTPEQTTAK-FLQVLQE-QKFKTGDHVDYYD 262
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A034UZ41 (Sepiapterin reductase OS=Bactrocera dorsalis OX=27457 GN=SPRE PE=4 SV=1) HSP 1 Score: 155.221 bits (391), Expect = 1.347e-41 Identity = 86/272 (31.62%), Postives = 152/272 (55.88%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYE-TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 K+ +F+TGA RG G+ ++ + S++++ R+E+ LL TK +E + ++V + DL V++ + + +L+K LK + + FE IIHNAG VGD+SK + + + V + + +N+ + +N + + +V +VN++S C+I+PF SMS YC+ KA REM+F+ LA E Q L ++ V+NY+PG +DTEM + + + EL + ++N ++ P+ + K F VL +K+G +D+YD Sbjct: 7 KRTYLFVTGASRGIGQRMSIEVAAKLKPGSIIVLLARSEQGLLNTKESIEALGNNVKVYTYSTDLSLVTATQFRELLEKSLKGVKISDFERAFIIHNAGTVGDVSKSAVDVSDANVWQQYYYVNVFSVISLNCEFFRVFSGTPKV----------VVNITSKCSIEPFASMSFYCSGKAAREMYFRVLATE----QALDNVVVLNYAPGAIDTEMTEQVQRESTNKELVGLFKKQRDNKTMLTPEQTTAK-FLQVLQE-QKFKTGDHVDYYD 262
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A0C9RNW5 (SPR protein OS=Fopius arisanus OX=64838 GN=SPR PE=4 SV=1) HSP 1 Score: 155.221 bits (391), Expect = 1.347e-41 Identity = 86/272 (31.62%), Postives = 152/272 (55.88%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYE-TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 K+ +F+TGA RG G+ ++ + S++++ R+E+ LL TK +E + ++V + DL V++ + + +L+K LK + + FE IIHNAG VGD+SK + + + V + + +N+ + +N + + +V +VN++S C+I+PF SMS YC+ KA REM+F+ LA E Q L ++ V+NY+PG +DTEM + + + EL + ++N ++ P+ + K F VL +K+G +D+YD Sbjct: 7 KRTYLFVTGASRGIGQRMSIEVAAKLKPGSIIVLLARSEQGLLNTKESIEALGNNVKVYTYSTDLSLVTATQFRELLEKSLKGVKISDFERAFIIHNAGTVGDVSKSAVDVSDANVWQQYYYVNVFSVISLNCEFFRVFSGTPKV----------VVNITSKCSIEPFASMSFYCSGKAAREMYFRVLATE----QALDNVVVLNYAPGAIDTEMTEQVQRESTNKELVGLFKKQRDNKTMLTPEQTTAK-FLQVLQE-QKFKTGDHVDYYD 262
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A0L0C4Y7 (Uncharacterized protein OS=Lucilia cuprina OX=7375 GN=FF38_08597 PE=4 SV=1) HSP 1 Score: 151.369 bits (381), Expect = 4.140e-40 Identity = 89/274 (32.48%), Postives = 149/274 (54.38%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSIL-DKILKLYE--TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 KK ITGA RG G++ A+ K + +S++++ RNE L +TK +E+ + ++V + LDL +++ + +L D +LK E FE IIHNAG VGD+SK + + + +V + + N+ T+ +N K + L+VN+SS C I+PF SMS YC+ KA R M+F LA E ++ D V+NY+PG +DT+M Y+ D S EL + ++ ++ + + K F ++L ++SG+ +D++D Sbjct: 7 KKTYFLITGASRGIGKTMAIEVSKLLKTDSVIVLIARNEDGLKKTKGSIESERSDLKVVTYSLDLSIAKAEDFQKLLTDSLLKSKEKINNFERAFIIHNAGTVGDVSKKAIDVSDTKVWTQYFHTNVFSTISLNVEFFKMFAFVPK----------LVVNISSKCGIEPFASMSFYCSGKAARNMYFGVLAAE----EKDNDTIVLNYAPGAIDTDMTVYVQDATISKELHDVFKSQRDTKTMLTTEKTTAK-FLSILKE-QKFESGAHVDYWD 264
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A1I8Q868 (Uncharacterized protein OS=Stomoxys calcitrans OX=35570 GN=106087827 PE=4 SV=1) HSP 1 Score: 149.058 bits (375), Expect = 3.021e-39 Identity = 90/276 (32.61%), Postives = 152/276 (55.07%), Query Frame = 3 Query: 105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF---VIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLI--LLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 KK ITGA RG G+S AL + S++++ RN L +TK +E+ + + V+V +DL T + + + I+ L + + F IIHNAG +GD+++ + E E + + + N+ T+ +N K P + L+VN+SSLC+I+PF SMS+YC+ KA REM+F+ LAVE ++ D V+NY+PG +DT+M + +++ + +L + ++N ++ +AEK F VL S +++G+ ID+YD Sbjct: 5 KKTFFLITGASRGIGKSMALEIASKLKAGSVILLMARNLEALQKTKSEIESKRSDVTVQVISIDLSTAKTVQFQKIISGSLVQSQQEVSSFDRAFIIHNAGTLGDVTRKAQEMGETELWTQYYHTNVFATIALNVEFFKVF------------PTVPKLVVNISSLCSIEPFISMSLYCSGKAAREMYFKVLAVE----EKDNDTLVLNYAPGAIDTDMTMIIQEDSFNLDLQDAFKTQRDNRTMLTTQQTAEK-FIKVLEEVS-FETGAHIDYYD 262
BLAST of Sepiapterin reductase vs. Ensembl Cavefish
Match: spra (sepiapterin reductase [Source:NCBI gene;Acc:103045273]) HSP 1 Score: 129.798 bits (325), Expect = 2.569e-35 Identity = 83/284 (29.23%), Postives = 149/284 (52.46%), Query Frame = 3 Query: 78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKL--LETKLLV-ETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920 M+ + E + L ITGA +GFG S A + S+L++ R+ KL L+ L E +A ++V DL + ++S++ + + + ++ +NA ++GD+S+ + F + ++S+ + N++ + + + +L + +++ +VNVSSLCA++PF S MYC KA R+M F+ LA E P+L V+NY+PGP+DT+M +A + + + E G+L+ + S KL +L + +Y SG+ +DFYDL Sbjct: 1 MASSQEKGFGRALCIITGASKGFGWSLAREIAPLLKPGSVLLLAARSGDKLQTLQADLAASEASSAGLQVRCVVADLG--QKEGVESVIAEAKETRCEDIDHLLLFNNAASLGDISRYAQSFTDMSEMDSYLSFNVSSALSLTSGILTAFPQRSGLQRC-------VVNVSSLCAVKPFRSWVMYCTGKAARDMMFRVLAEEE------PELRVLNYAPGPLDTDMQLQARSTSADENMRKSFADMHEEGRLLTCEESVAKLLKVLLED--DYPSGTHLDFYDL 267
BLAST of Sepiapterin reductase vs. Ensembl Nematostella
Match: EDO46442 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ68]) HSP 1 Score: 107.457 bits (267), Expect = 2.140e-27 Identity = 74/269 (27.51%), Postives = 139/269 (51.67%), Query Frame = 3 Query: 123 ITGAGRGFGRSCALVAGKFFEN---ESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILK-LYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917 ITGA RG G A+ + + E I+ RN+ L +T V + + I+ + DL + D ++ +LD I + + + F ++++NAG++GDLS+ +F + ++ + +N+T I+ + + E + + + N+SSL AIQ ++ S+YC KA R+M LA E + D+ ++NY+PGP+DT+M + + + + E+ + G ++ P S++KL +L + YKSG+ +D++D Sbjct: 12 ITGASRGLGCCIAVSIAEVAQAQNCEVTFILVARNKEGLEKTLNQVRQVKSSIKGFLIVGDLGKL--DTLQGLLDDIFQCVTPSAFSHSLLVNNAGSLGDLSRPMKDFTDPDEVQQYMGLNLTSPFIIASRFVNEFKSTKR----------YIANISSLMAIQAWKGFSLYCVGKASRDMAHSVLATEED------DVRILNYAPGPLDTDMNNIIQEWSYNQEVKQML----NKGNVLRPKQSSDKLVQILLDD--TYKSGAHLDYFD 256
BLAST of Sepiapterin reductase vs. Ensembl Nematostella
Match: EDO41444 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4B0]) HSP 1 Score: 46.595 bits (109), Expect = 5.675e-6 Identity = 51/219 (23.29%), Postives = 101/219 (46.12%), Query Frame = 3 Query: 93 ELKMKKNLIFITGAGRGFGRSCA-LVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEM 746 +LK + +TG G GR A +AG+ +++ R+ KL + + +E+ + ++ ++ D + E+ LD+ L + + ++++N G +++ + ++ V N+N V++ +++L + + ++VNVSSL P MS+YCA KAF + F CL E+ +K +FV P + T+M Sbjct: 46 DLKRYGSWAVVTGCTDGIGRCYAEKLAGRGLN----IVLISRSLEKLKQVQQHIESQFS-VQTKIIVKDFG--GNAEVYQDLDEQL----SNLDIGILVNNVGMASMINR--FADLKIEVCWKMLNVNALSAVMMTHIVLPGML---------SRQRGVVVNVSSLVGSDPMPLMSVYCATKAFLDFFSSCLHSEYSSK----GIFVQCVRPAFVATKM 238
BLAST of Sepiapterin reductase vs. Ensembl Medaka
Match: spra (sepiapterin reductase [Source:NCBI gene;Acc:110015794]) HSP 1 Score: 133.265 bits (334), Expect = 1.044e-36 Identity = 83/276 (30.07%), Postives = 149/276 (53.99%), Query Frame = 3 Query: 102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGR--NERKLLETKLL-VETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920 + + L ITGA RGFGR+ A + + S+L++ R +E + L+ +L E A ++V+V D+ ++ +++I+ + + + ++I+NA ++GD+S+ + F + ++S+ ++N++ ++ + +L+ +R +VNV+SLCA+QPF S +YC KA REM F+ LA E P+L V+NYSPGP+DTEM A ++ +K G+L+ + S KL +L + + SG+ ID YD+ Sbjct: 7 LGRALCIITGASRGFGRAVARDLSRLVQPGSVLVLAARSGDELRALQAELTDSEAGRAGLKVQVAVADVG--RTEGLEAIIRSSAEAFSENIDRVILINNAASLGDVSRFTRSFTDMAEVDSYLSLNVSSSLCLTARVLQAFPGRGGLRHT-------VVNVTSLCALQPFRSWVLYCTGKAAREMMFRVLAEEE------PELRVLNYSPGPLDTEMQQEARSRTADPDVKIAFSDMKTRGQLLTCEESCAKLMKVLLED--GFSSGAHIDVYDV 265
BLAST of Sepiapterin reductase vs. Ensembl Medaka
Match: dhrs7b (dehydrogenase/reductase 7B [Source:NCBI gene;Acc:101157135]) HSP 1 Score: 57.3806 bits (137), Expect = 5.723e-9 Identity = 57/219 (26.03%), Postives = 95/219 (43.38%), Query Frame = 3 Query: 114 LIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLD---LETVSSDEIKSILDKILKLYETQFECFVIIHNAG-----NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEM 746 ++ ITGA G G+ CA V F + L++CGR+ +L + + + + F + +D I ++ILK Y V+I+NAG N+ D ++ ++R V+E+ N G + + LL + H R++ +V +SS+ S S Y A K + FF CL E E + V SPG + T++ Sbjct: 35 VVVITGASSGLGKECARV---FHAAGARLVVCGRDAGRLQQVVQELTASTTATQKQTFSPSTVIFDLAKADTIGKAAEEILKCYG---HVDVLINNAGISYRGNILD----THISVQREVMET----NYFGPISLTQALLPSMVH----RRSGH-----IVVISSVQGKIAIPSRSAYAASKHATQAFFDCLRAEIEQN----GISVTVISPGYIQTDL 226
BLAST of Sepiapterin reductase vs. Planmine SMEST
Match: SMESG000026493.1 (SMESG000026493.1) HSP 1 Score: 565.459 bits (1456), Expect = 0.000e+0 Identity = 276/281 (98.22%), Postives = 277/281 (98.58%), Query Frame = 3 Query: 78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKL ETQFECFVIIHNAGNVGDLSKCSYEFMER+VIESFTNINMTGTVIVNNVLLKEI HSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLF INYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANY NYKSGSRIDFYDL Sbjct: 1 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLSETQFECFVIIHNAGNVGDLSKCSYEFMERKVIESFTNINMTGTVIVNNVLLKEISHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFAINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYFNYKSGSRIDFYDL 281
BLAST of Sepiapterin reductase vs. Planmine SMEST
Match: SMESG000079254.1 (SMESG000079254.1) HSP 1 Score: 58.151 bits (139), Expect = 1.309e-9 Identity = 64/219 (29.22%), Postives = 103/219 (47.03%), Query Frame = 3 Query: 78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVE--TMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPG 728 M + L K LI TGA G G+S A + FF+ + ++I GRN L +T L E +N R+ F DL + +++K + +K L +F I+ N N G +S + E +E +S N+N+ + + N+L + RK + +VNVSS+ + F ++ YC KA E F +C A++ +K + V SPG Sbjct: 1 MIHKFSLNFKNALI--TGASSGIGKSTAEL---FFKLGANILITGRNLENLNDTIKLCELSKVNENQRIVAFTADL--TNEEDVKKLAEKTL----LEFPKLDILIN--NAGVISNDTIENVEMENFDSVMNMNLRSVIQLTNLLSPSLID----RKGS------IVNVSSVAGTRAFPNVMSYCISKAALEQFTKCTALDLASK----GVRVNAVSPG 192
BLAST of Sepiapterin reductase vs. Planmine SMEST
Match: SMESG000079251.1 (SMESG000079251.1) HSP 1 Score: 57.7658 bits (138), Expect = 2.070e-9 Identity = 60/239 (25.10%), Postives = 111/239 (46.44%), Query Frame = 3 Query: 120 FITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYL-IDNAASDELTSQMRILKENGKLINP 833 ITGA G GR+ A + FF+ + L+I GRN+ L +T LL E + ++ + + D+I+ + +K L + Q + ++I+NA G L + E + + N+N+ + + ++L + + KA +VNVSS+ + F + YC KA + F +C A++ K + V +PG + T++ +D +A E + ++ G+ NP Sbjct: 12 LITGASSGVGRATADL---FFQLGANLVITGRNDDNLKDTALLCEKHRVMENQKLVMFLADLANEDDIRKLAEKTLSEF-VQLD--ILINNA---GILLNDTIETVSMDQFDMNINLNLRAVIQLTHLL------TPSLIKAKGS----IVNVSSVAGSKSFPGIMSYCIGKAGLDQFTRCAALDLAKK----GVRVNAVNPGVILTDIHKRAGMDESAYQEFLQRAQLTHALGRFGNP 227 The following BLAST results are available for this feature:
BLAST of Sepiapterin reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 3
BLAST of Sepiapterin reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of Sepiapterin reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Sepiapterin reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of Sepiapterin reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Sepiapterin reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Sepiapterin reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of Sepiapterin reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Sepiapterin reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Sepiapterin reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Sepiapterin reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of Sepiapterin reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035504 ID=SMED30035504|Name=Sepiapterin reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=979bpback to top protein sequence of SMED30035504-orf-1 >SMED30035504-orf-1 ID=SMED30035504-orf-1|Name=SMED30035504-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=282bp MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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