Sepiapterin reductase

Overview
NameSepiapterin reductase
Smed IDSMED30035504
Length (bp)979
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Sepiapterin reductase (SMED30035504) t-SNE clustered cells

Violin plots show distribution of expression levels for Sepiapterin reductase (SMED30035504) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Sepiapterin reductase (SMED30035504) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Sepiapterin reductase (SMED30035504) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30035504

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30035504SMESG000026493.1 dd_Smed_v4_4189_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30035504SMESG000026493.1 dd_Smed_v4_4189_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30035504SMESG000026493.1 Contig39982uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30035504SMESG000026493.1 Contig39982newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Human
Match: SPR (sepiapterin reductase [Source:HGNC Symbol;Acc:HGNC:11257])

HSP 1 Score: 139.043 bits (349), Expect = 1.257e-38
Identity = 83/276 (30.07%), Postives = 151/276 (54.71%), Query Frame = 3 
Query:   93 ELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            E  + + +  +TGA RGFGR+ A +        S+L++  RN+  L + +  +    + +RV     DL   +   ++ +L  + +L   +  +  ++I+NAG++GD+SK   +  +   + ++  +N+T  + + + +LK    S  + +        +VN+SSLCA+QPF+  ++YCA KA R+M FQ LA+E       P++ V+NY+PGP+DT+M     + +   ++   ++ LK  GKL++   SA+KL    L     +KSG+ +DFYD
Sbjct:    2 EGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAG--LQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRT-------VVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEE------PNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLS--LLEKDEFKSGAHVDFYD 260
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Human
Match: DHRS7B (dehydrogenase/reductase 7B [Source:HGNC Symbol;Acc:HGNC:24547])

HSP 1 Score: 52.373 bits (124), Expect = 4.249e-7
Identity = 66/245 (26.94%), Postives = 111/245 (45.31%), Query Frame = 3 
Query:  102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVE-TMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAAS-----DELTSQMR 800
            ++  ++ ITGA  G G+ CA V   F+   + L++CGRN   L E  L+ E T +   +V+  K  L T    +  +I+    ++     +CF    ++++NAG    G +   + + +++RV+E+    N  G V +   LL  +    + R+ +      +V +SS+         S Y A K   + FF CL  E E  Q   ++ VI  SPG + T +    I    S     D  T+Q R
Sbjct:   50 LRNAVVVITGATSGLGKECAKV---FYAAGAKLVLCGRNGGALEE--LIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEI----LQCFGYVDILVNNAGISYRGTIMDTTVD-VDKRVMET----NYFGPVALTKALLPSM---IKRRQGH------IVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME--QYEIEVTVI--SPGYIHTNLSVNAITADGSRYGVMDTTTAQGR 267
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Human
Match: DHRS7B (dehydrogenase/reductase 7B [Source:HGNC Symbol;Acc:HGNC:24547])

HSP 1 Score: 51.9878 bits (123), Expect = 4.856e-7
Identity = 66/245 (26.94%), Postives = 111/245 (45.31%), Query Frame = 3 
Query:  102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVE-TMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAAS-----DELTSQMR 800
            ++  ++ ITGA  G G+ CA V   F+   + L++CGRN   L E  L+ E T +   +V+  K  L T    +  +I+    ++     +CF    ++++NAG    G +   + + +++RV+E+    N  G V +   LL  +    + R+ +      +V +SS+         S Y A K   + FF CL  E E  Q   ++ VI  SPG + T +    I    S     D  T+Q R
Sbjct:   35 LRNAVVVITGATSGLGKECAKV---FYAAGAKLVLCGRNGGALEE--LIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEI----LQCFGYVDILVNNAGISYRGTIMDTTVD-VDKRVMET----NYFGPVALTKALLPSM---IKRRQGH------IVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME--QYEIEVTVI--SPGYIHTNLSVNAITADGSRYGVMDTTTAQGR 252
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Celegans
Match: dhs-21 (L-xylulose reductase [Source:UniProtKB/Swiss-Prot;Acc:Q21929])

HSP 1 Score: 55.4546 bits (132), Expect = 1.066e-8
Identity = 49/205 (23.90%), Postives = 96/205 (46.83%), Query Frame = 3 
Query:   78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGD--LSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAK 686
            M   Y+   K+  I +TGA +G G+   L   K     + +I   RNE  LL   L+ ET +  +R  +  +  +  +++E+      + KL    F    +++NAG   +  + + + + ++R    +     +   ++  N + ++I+ S             +VN+SS  AI+P ++ ++YCA KA  +M  +CLA E  ++
Sbjct:    1 MPANYDFTDKR--ILVTGASQGIGKEICLSLAKA---GAQVIAFARNEANLLS--LVKETTS--LRYTIIPIVGDVSANEEV------LFKLIVPHFPIHGLVNNAGIATNHAIGQITQQSIDRTFAVNVRGPILIAQLVARNFVDRQIKGS-------------IVNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQ 177
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BLAST of Sepiapterin reductase vs. Ensembl Celegans
Match: Y47G6A.21 (pep chromosome:WBcel235:I:3551949:3559807:-1 gene:WBGene00021646.1 transcript:Y47G6A.21.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y47G6A.21)

HSP 1 Score: 48.1358 bits (113), Expect = 2.722e-6
Identity = 47/188 (25.00%), Postives = 81/188 (43.09%), Query Frame = 3 
Query:  120 FITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEW 677
             ITGA  G G+  AL+   F + +  L + GRN   L E   L  +  A+   ++    +E  S +  K+I+D  ++ +        +I++AG    G +     E     V +   N+N+   + +    L  I  +             +VNVSS+    PF  ++ YC  K+  + F +CLA+E 
Sbjct:    5 IITGASSGIGKGTALL---FAKKKYQLSLTGRNTDSLKEVAALCISEGAISADDILITAVELSSDEAPKAIVDATVQKFG---RIDSLINSAGILRAGPVLDSGIE-----VYDELMNVNVRSLIRLTRAALPHIITTKGT----------VVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEM 171
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: Sptr (gene:FBgn0014032 transcript:FBtr0071241)

HSP 1 Score: 134.806 bits (338), Expect = 2.461e-37
Identity = 86/272 (31.62%), Postives = 144/272 (52.94%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENE-SLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            ++  + +TGA RG GR  A    K  + E S++ + GRN+  L E+K  +      + V+ + L+LET  +++   IL+      +  FE  ++IHNAG VGD SK + E  +   ++ + + N+   + +N   ++       V K   K   L+VN+S+L AI P  SM+ YC +KA REM+F+ LA E  A+    D  V+NY+PG +DT+M   +   A    + +  R  +E+  ++ P  + E+ F  VL  +  +KSG  +D+ D
Sbjct:    5 QRTYLLVTGASRGIGREFAQQLAKRIKAEGSMVTLLGRNQTLLQESKAEIVATVPDLSVQTYSLELETAKTEDFTKILEA--SGGKNNFERAIVIHNAGTVGDTSKRAKEIGDTDFLQRYYHSNVFSAISLNCEFMR-------VFKGIPK---LVVNLSTLAAIAPISSMAHYCTVKAAREMYFRVLATEESAE----DTLVLNYAPGVIDTQMTVQVQREAHDPAVVAMFREQRESKTMLTPAQTTER-FIKVLEAF-KFKSGDHVDYRD 258
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG12116 (gene:FBgn0030041 transcript:FBtr0071240)

HSP 1 Score: 62.3882 bits (150), Expect = 8.493e-11
Identity = 67/278 (24.10%), Postives = 128/278 (46.04%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKL--LETKLLVETMNALIRVEVFKLDLETVSSDEI--KSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDN--AASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            ++  + ++G+    G+S AL   +     SL +I   ++ +L  LE  L  E     ++V + KLD +  +  ++  ++++D  +   + Q FE  +I+HN G     +    E       +++    +   V +N   L+  +H   V K       L VNV+S   ++P     + C+ K  R+M+F+ +A E   + R   + V+++SPG MDT      ++       +L +  ++L+     I P  +  KL  N+L   S + SG  +D+YD
Sbjct:   10 RRTFLVLSGSSNPLGQSLALEFCRRLATGSLALILDEDQEQLRELENHLRSELKTENVKVTIGKLDKDHSNGVQLMEQALMDNFMADKDNQRFERSIILHNEGKAA--THMLLEPQSDDDWKAYVQQQLYAPVALNQTWLQS-KHLERVEK-------LAVNVTSSLMVRPLVHAGLLCSCKRARDMYFRAMAAE---EYRF-GVHVLSFSPGLMDTHEGQCDVNGNRITPADLIATKQLLQL--PRIKPCQATLKLI-NILEEIS-FVSGHDVDYYD 269
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG31549 (gene:FBgn0051549 transcript:FBtr0078707)

HSP 1 Score: 58.5362 bits (140), Expect = 1.180e-9
Identity = 62/229 (27.07%), Postives = 99/229 (43.23%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQ-RL----PDLFVIN-YSPGPMDTEMMAYLIDN 767
            K  +I +TGA  G G S A+   K      LL+I GRNE KL ET    + + A       +L  +     E++ I+   L  +       V+++NAG    G +   S E  +R       N N+     +  +   E+  +    K N      +VNVSS+C ++ F  +  Y   KA  + F  C+A+E   K  R+    P + V + +  G MD E  A  +++
Sbjct:    5 KDKVIIVTGASSGIGASAAVHLAKL---GGLLVIVGRNEEKLKET---ADNIVAAGGATPLELQADMTKEAEVQQIVGATLAKHG---RIDVLVNNAGILETGSIEATSLEQFDR-----LMNTNVRSLYQLTMLATPELVKT----KGN------IVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTDIHKRGGMDEETYAKFLEH 209
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG31549 (gene:FBgn0051549 transcript:FBtr0335215)

HSP 1 Score: 58.5362 bits (140), Expect = 1.180e-9
Identity = 62/229 (27.07%), Postives = 99/229 (43.23%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQ-RL----PDLFVIN-YSPGPMDTEMMAYLIDN 767
            K  +I +TGA  G G S A+   K      LL+I GRNE KL ET    + + A       +L  +     E++ I+   L  +       V+++NAG    G +   S E  +R       N N+     +  +   E+  +    K N      +VNVSS+C ++ F  +  Y   KA  + F  C+A+E   K  R+    P + V + +  G MD E  A  +++
Sbjct:    5 KDKVIIVTGASSGIGASAAVHLAKL---GGLLVIVGRNEEKLKET---ADNIVAAGGATPLELQADMTKEAEVQQIVGATLAKHG---RIDVLVNNAGILETGSIEATSLEQFDR-----LMNTNVRSLYQLTMLATPELVKT----KGN------IVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTDIHKRGGMDEETYAKFLEH 209
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Fly
Match: CG12171 (gene:FBgn0037354 transcript:FBtr0078708)

HSP 1 Score: 50.8322 bits (120), Expect = 5.038e-7
Identity = 56/216 (25.93%), Postives = 96/216 (44.44%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEM 746
            K  +I +TGA  G G   +++  K      LL I GRN  KL ET    E + A       ++  +  S  +++ I+   L  +       V+++NAG   +G +   S E  +R       N N+     + +++  E+  +    K N      +VNVSS+  I+ F  +  Y   KA  + F +C+A+E   K     + V + +PG + TE+
Sbjct:    5 KDKVIIVTGASSGIGAGTSVLLAKL---GGLLTIVGRNLDKLNET---AEQIVAAGGAPALQVAADINSESDVQGIVSATLAKHG---RIDVLVNNAGILELGSIENTSLEQFDR-----VMNTNVRSLYQLTHLVTPELIKT----KGN------IVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPK----GVRVNSVNPGVIITEL 192
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Zebrafish
Match: spra (sepiapterin reductase a [Source:ZFIN;Acc:ZDB-GENE-050522-412])

HSP 1 Score: 139.043 bits (349), Expect = 8.985e-39
Identity = 85/271 (31.37%), Postives = 144/271 (53.14%), Query Frame = 3 
Query:  108 KNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920
            K L+ ITGA RGFGR+ AL         S+L++  R+E +LLE K  +      + V    +DL   +  E K I +   +  +   +  ++ HNA ++GD+S+   +F     + S+ ++N++  + +   +L+     + + +       ++VN+SSLCA++PF +   YC+ KA R+M F+ LA E       P+L V+NY+PGP+DT+M      + A  EL +    +  NG+L+  D S +KL   +L +   Y SG  +D+YDL
Sbjct:    9 KALVIITGASRGFGRALALSVAARVSPGSVLVLAARSEEQLLELKSALTRGETGLTVRCVPVDLGCEAGVE-KLIAET--RDIQPDIQHLLLFHNAASLGDVSRYCRDFTNMEELNSYLSLNVSSALCLTAGVLRTYPKRSGLTR-------VIVNISSLCALRPFPTWVQYCSGKAARDMMFRVLAEEE------PELRVLNYAPGPLDTDMQREARSSCADSELRNTFSQMHANGQLLTCDQSIQKLMSVLLED--KYSSGEHLDYYDL 261
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Zebrafish
Match: sprb (sepiapterin reductase b [Source:ZFIN;Acc:ZDB-GENE-070719-1])

HSP 1 Score: 129.798 bits (325), Expect = 3.276e-35
Identity = 76/276 (27.54%), Postives = 149/276 (53.99%), Query Frame = 3 
Query:  102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNAL---IRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920
            + + +  +TGA +G+GR+ AL      +  S+L++  R   +L + K  + +++A    ++++V  +  +    D ++  + +      T  E  +II+NA ++GD+S+C+  F +   +  +  +N++G + +   +L+    +  +R+        +VN+SSLCA++PF S  +YC  KA R+M F+ LA E       PDL V++Y+PGP+DT+M       + + EL      +  +G+L++ + S  KL   +L +   Y SG+ +D+Y+L
Sbjct:   12 LGRAVCVVTGASKGYGRTLALQISCLLKPRSVLLLVSRTADQLNQLKQDIVSLHAAHTDLQLDVRCVQADLQEPDGVQKTIQETRNTLSTDIEHLLIINNAASLGDVSRCAVSFTDPCEVSRYLALNVSGVLSLTAGILQAFPPAVGLRRT-------VVNISSLCALKPFPSWVLYCTGKAARDMMFRVLAEEE------PDLRVLSYAPGPLDTDMQLQARCFSGNVELRRSFSSMFSDGQLLSCEESGAKLMKILLDD--QYPSGAHLDYYEL 272
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Xenopus
Match: dock8 (dedicator of cytokinesis 8 [Source:Xenbase;Acc:XB-GENE-987088])

HSP 1 Score: 104.375 bits (259), Expect = 1.257e-26
Identity = 60/174 (34.48%), Postives = 98/174 (56.32%), Query Frame = 3 
Query:  396 GNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            G++GD+SK   +F + + +  +   N++  + +   LLK      ++++       ++VNVSSL A+QPF+S ++YC+ KA R+M F+ LA E +      D+ V+NY+PGP+DT+M        A  EL   +   KE GK+++   SA+K+    L     YKSG  IDF+D
Sbjct:    1 GSIGDVSKMFVDFSDPKEVTDYMMFNVSSPLCLTASLLKTFPRRPDLQR-------VVVNVSSLAALQPFKSWALYCSGKAARDMIFRVLAEEEK------DVRVLNYAPGPLDTDMHVVARTQTADQELRRFLMDRKEKGKMVDIQVSAKKMLD--LLEADAYKSGDHIDFFD 159
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Xenopus
Match: gria4 (glutamate receptor, ionotropic, AMPA 4 [Source:Xenbase;Acc:XB-GENE-5838893])

HSP 1 Score: 53.9138 bits (128), Expect = 1.255e-7
Identity = 58/234 (24.79%), Postives = 106/234 (45.30%), Query Frame = 3 
Query:   87 TYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERR--VIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDE 782
            T E K+  N++++TGA  G G   +    K       L++  R E +LL  K     +++L   ++  L L+   +   K   +K L+ +       ++++NAG     S+ S  F+E    V  +   +N  GT+ +   +L+   H  E ++        +VN+SS+  +      S Y A K   + FF  L  E  A    PD+ + N  PGP+ ++    +++NA ++E
Sbjct:   43 TPESKLGGNVVWVTGASSGIGEELSYQLAKI---GCPLVLSSRRETELLRVKQKCLEISSLEDQDILILPLDMTQTSMHKEATEKALQHFG---RIDILVNNAGR----SQRSL-FVETNLDVFRALIELNYLGTISITKHVLQ---HMIERKQGK------IVNISSVVGLIGAPLSSGYSASKHALQGFFNSLRTELTA---YPDIIISNICPGPVQSK----IVENALTEE 249
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Spr (sepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078])

HSP 1 Score: 132.494 bits (332), Expect = 2.683e-36
Identity = 78/266 (29.32%), Postives = 142/266 (53.38%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            +TGA RGFGR+ A    +     S++++  R+E  L + K  +      ++V +   DL T +   ++ +L  + +L   +  +  ++I+NA  +GD+SK      +   + ++  +N+T  + + +  L   + S  + K        +VN+SSLCA+QP++   +YCA KA R+M +Q LA E       P + V++Y+PGP+D +M     + +   EL S+++ LK +G L++   SA+KL    L     ++SG+ +DFYD
Sbjct:   13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT-------VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 261
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Spr (sepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078])

HSP 1 Score: 132.494 bits (332), Expect = 2.683e-36
Identity = 78/266 (29.32%), Postives = 142/266 (53.38%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            +TGA RGFGR+ A    +     S++++  R+E  L + K  +      ++V +   DL T +   ++ +L  + +L   +  +  ++I+NA  +GD+SK      +   + ++  +N+T  + + +  L   + S  + K        +VN+SSLCA+QP++   +YCA KA R+M +Q LA E       P + V++Y+PGP+D +M     + +   EL S+++ LK +G L++   SA+KL    L     ++SG+ +DFYD
Sbjct:   13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT-------VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 261
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Spr (sepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078])

HSP 1 Score: 98.2117 bits (243), Expect = 7.180e-24
Identity = 68/266 (25.56%), Postives = 120/266 (45.11%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            +TGA RGFGR+ A    +     S++++  R+E  L + K  +      ++V +   DL T +   ++ +L  + +L   +  +  ++I+NA  +GD+SK             F N+N                                         +P++   +YCA KA R+M +Q LA E       P + V++Y+PGP+D +M     + +   EL S+++ LK +G L++   SA+KL    L     ++SG+ +DFYD
Sbjct:   13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSK------------GFLNVNDL--------------------------------------AEPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 218
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Dhrs7b (dehydrogenase/reductase (SDR family) member 7B [Source:MGI Symbol;Acc:MGI:2384931])

HSP 1 Score: 53.1434 bits (126), Expect = 1.583e-7
Identity = 69/255 (27.06%), Postives = 110/255 (43.14%), Query Frame = 3 
Query:   81 SKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMM--AYLIDNA---ASDELTSQMRILKE 812
            SK Y   ++  ++ +TGA  G GR CA V   F    + L++CGRN + L E    +   +     + F +  +      I +   +IL       +CF    V+I+NAG    G +S    + ++R+V+E    IN  G V +   LL  +    E ++ +      +V +SS+         S Y A K   + FF CL  E E      ++ V   SPG + T +   A   D +   A D+ T+Q R   E
Sbjct:   31 SKAY---LRNAVVVVTGATSGLGRECAKV---FHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFVVTFDLADPGTIAAAAAEIL-------QCFGYVDVLINNAGISYRGTISDTIVD-VDRKVME----INYFGPVALTKALLPSM---VERKQGH------IVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEMEEA----NIKVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAAE 254
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Mouse
Match: Dhrs7b (dehydrogenase/reductase (SDR family) member 7B [Source:MGI Symbol;Acc:MGI:2384931])

HSP 1 Score: 53.1434 bits (126), Expect = 1.743e-7
Identity = 69/255 (27.06%), Postives = 110/255 (43.14%), Query Frame = 3 
Query:   81 SKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF----VIIHNAG--NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMM--AYLIDNA---ASDELTSQMRILKE 812
            SK Y   ++  ++ +TGA  G GR CA V   F    + L++CGRN + L E    +   +     + F +  +      I +   +IL       +CF    V+I+NAG    G +S    + ++R+V+E    IN  G V +   LL  +    E ++ +      +V +SS+         S Y A K   + FF CL  E E      ++ V   SPG + T +   A   D +   A D+ T+Q R   E
Sbjct:   46 SKAY---LRNAVVVVTGATSGLGRECAKV---FHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFVVTFDLADPGTIAAAAAEIL-------QCFGYVDVLINNAGISYRGTISDTIVD-VDRKVME----INYFGPVALTKALLPSM---VERKQGH------IVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEMEEA----NIKVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAAE 269
[Close]
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|Q17QK8|SPRE_BOVIN (Sepiapterin reductase OS=Bos taurus OX=9913 GN=SPR PE=2 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 2.082e-38
Identity = 86/275 (31.27%), Postives = 149/275 (54.18%), Query Frame = 3 
Query:  102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKL--LETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            + + L  +TGA RGFGR+ A V        S+L++  RN+  L  LET+L  E     +R+     DL   +   ++ ++  +  L   +  +  ++I+NAG +GD+SK   +  +   + ++  +N+T T+ + + +L+    S  + +        +VN+SS+CA+QPF+   +YCA KA R M FQ LA E       P + V++Y PGP+DT+M     + +   +L   ++ LK  G+L++   SA+KL  ++L N   ++SG+ IDFYD
Sbjct:   11 LGRTLCVLTGASRGFGRTLAQVLAPLMSPRSVLVLSARNDEALRQLETELGAEWPG--LRIVRVPADLGAETG--LQQLVGALCDLPRPEGLQRVLLINNAGTLGDVSKRWVDLTDPTEVNNYWTLNLTSTLCLTSSILQAFPDSPGLSRT-------VVNISSICALQPFKGWGLYCAGKAARNMMFQVLAAE------EPSVRVLSYGPGPLDTDMQQLARETSVDPDLRKSLQELKRKGELVDCKISAQKLL-SLLQN-DKFESGAHIDFYD 266
[Close]
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|P35270|SPRE_HUMAN (Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 6.037e-38
Identity = 83/276 (30.07%), Postives = 151/276 (54.71%), Query Frame = 3 
Query:   93 ELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            E  + + +  +TGA RGFGR+ A +        S+L++  RN+  L + +  +    + +RV     DL   +   ++ +L  + +L   +  +  ++I+NAG++GD+SK   +  +   + ++  +N+T  + + + +LK    S  + +        +VN+SSLCA+QPF+  ++YCA KA R+M FQ LA+E       P++ V+NY+PGP+DT+M     + +   ++   ++ LK  GKL++   SA+KL    L     +KSG+ +DFYD
Sbjct:    2 EGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAG--LQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRT-------VVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEE------PNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLS--LLEKDEFKSGAHVDFYD 260
[Close]
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|P18297|SPRE_RAT (Sepiapterin reductase OS=Rattus norvegicus OX=10116 GN=Spr PE=1 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 5.469e-37
Identity = 83/267 (31.09%), Postives = 143/267 (53.56%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920
            +TGA RGFGR+ A          S+L++  R++  L + K  + T    ++V +   DL T S   ++ +L  + +L   +  +  ++I+NAG +GD+SK      +   + ++  +N+T  + +    L    +S  + K        +VN+SSLCA+QPF+   +YCA KA R+M +Q LAVE       P + V++Y+PGP+DT M     + +   EL S+++ L   G+L++   SA+KL    L     ++SG+ +DFYD+
Sbjct:   13 LTGASRGFGRALAPQLAGLLSPGSVLLLSARSDSMLRQLKEELCTQQPGLQVVLAAADLGTESG--VQQLLSAVRELPRPERLQRLLLINNAGTLGDVSKGFLNINDLAEVNNYWALNLTSMLCLTTGTLNAFSNSPGLSKT-------VVNISSLCALQPFKGWGLYCAGKAARDMLYQVLAVEE------PSVRVLSYAPGPLDTNMQQLARETSMDPELRSRLQKLNSEGELVDCGTSAQKLLS--LLQRDTFQSGAHVDFYDI 262
[Close]
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|Q8R536|SPRE_MERUN (Sepiapterin reductase OS=Meriones unguiculatus OX=10047 GN=SPR PE=2 SV=1)

HSP 1 Score: 133.65 bits (335), Expect = 7.988e-36
Identity = 80/266 (30.08%), Postives = 141/266 (53.01%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            +TGA RGFGR+ A    +     S+L++C R++  L   +  +      +RV     DL T +   ++ +L  + +L + +  +  ++I+NAG +GD+SK      +   + ++  +N+T  + + +  L     S  + K        +VN+SSLCA+QPF+   +YC  KA R+M  Q LA E       P + V++Y+PGP+DT+M     + +   EL ++++ LK  G+L++   SA+KL    L     ++SG+ +DFYD
Sbjct:   13 LTGASRGFGRALAPRLAQLLAPGSVLLLCARSDSALRRLEEELGAQQPGLRVVRAAADLGTEAG--LRQVLRAVRELPKPEGLQRLLLINNAGTLGDVSKGVLNVNDPAEVNNYWALNLTSMLCLTSGTLNAFPDSPGLSKT-------VVNISSLCALQPFKGWGLYCTGKAARDMLCQVLAAEE------PSVRVLSYAPGPLDTDMQQLARETSMDPELRNRLQRLKSEGELVDCGTSAQKLLN--LLQKDTFQSGAHVDFYD 261
[Close]
BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Match: sp|Q64105|SPRE_MOUSE (Sepiapterin reductase OS=Mus musculus OX=10090 GN=Spr PE=1 SV=1)

HSP 1 Score: 132.494 bits (332), Expect = 1.647e-35
Identity = 78/266 (29.32%), Postives = 142/266 (53.38%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQ-FECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            +TGA RGFGR+ A    +     S++++  R+E  L + K  +      ++V +   DL T +   ++ +L  + +L   +  +  ++I+NA  +GD+SK      +   + ++  +N+T  + + +  L   + S  + K        +VN+SSLCA+QP++   +YCA KA R+M +Q LA E       P + V++Y+PGP+D +M     + +   EL S+++ LK +G L++   SA+KL    L     ++SG+ +DFYD
Sbjct:   13 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAG--VQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT-------VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEE------PSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLG--LLQKDTFQSGAHVDFYD 261
[Close]
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A0K8UBL0 (Sepiapterin reductase OS=Bactrocera latifrons OX=174628 GN=SPR PE=4 SV=1)

HSP 1 Score: 155.992 bits (393), Expect = 6.253e-42
Identity = 87/272 (31.99%), Postives = 152/272 (55.88%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYE-TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            K+  +F+TGA RG G+  ++      +  S++++  R+E+ LL TK  +E +   ++V  +  DL  V++ +++ +L+K LK  + + FE   IIHNAG VGD+SK + +  +  V   +  +N+   + +N    +    + +V          +VN++S CAI+PF SMS YC+ KA REM+F+ LA E    Q L ++ V+NY+PG +DTEM   +   + + EL    +  ++N  ++ P+ +  K F  VL     +K+G  +D+YD
Sbjct:    7 KRTYLFVTGASRGIGQRMSIEVAAKLKPGSIIVLLARSEQGLLNTKESIEALGNDLKVYTYSTDLSLVTATQLRELLEKSLKGVKISDFERAFIIHNAGTVGDVSKSAVDVSDANVWHQYYYVNVFSVISLNCEFFRVFSGTPKV----------VVNITSKCAIEPFASMSFYCSGKAAREMYFRVLATE----QALDNVVVLNYAPGAIDTEMTEQVQRESTNKELVGLFKKQRDNKTMLTPEQTTAK-FLQVLQE-QKFKTGDHVDYYD 262
[Close]
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A034UZ41 (Sepiapterin reductase OS=Bactrocera dorsalis OX=27457 GN=SPRE PE=4 SV=1)

HSP 1 Score: 155.221 bits (391), Expect = 1.347e-41
Identity = 86/272 (31.62%), Postives = 152/272 (55.88%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYE-TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            K+  +F+TGA RG G+  ++      +  S++++  R+E+ LL TK  +E +   ++V  +  DL  V++ + + +L+K LK  + + FE   IIHNAG VGD+SK + +  +  V + +  +N+   + +N    +    + +V          +VN++S C+I+PF SMS YC+ KA REM+F+ LA E    Q L ++ V+NY+PG +DTEM   +   + + EL    +  ++N  ++ P+ +  K F  VL     +K+G  +D+YD
Sbjct:    7 KRTYLFVTGASRGIGQRMSIEVAAKLKPGSIIVLLARSEQGLLNTKESIEALGNNVKVYTYSTDLSLVTATQFRELLEKSLKGVKISDFERAFIIHNAGTVGDVSKSAVDVSDANVWQQYYYVNVFSVISLNCEFFRVFSGTPKV----------VVNITSKCSIEPFASMSFYCSGKAAREMYFRVLATE----QALDNVVVLNYAPGAIDTEMTEQVQRESTNKELVGLFKKQRDNKTMLTPEQTTAK-FLQVLQE-QKFKTGDHVDYYD 262
[Close]
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A0C9RNW5 (SPR protein OS=Fopius arisanus OX=64838 GN=SPR PE=4 SV=1)

HSP 1 Score: 155.221 bits (391), Expect = 1.347e-41
Identity = 86/272 (31.62%), Postives = 152/272 (55.88%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYE-TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            K+  +F+TGA RG G+  ++      +  S++++  R+E+ LL TK  +E +   ++V  +  DL  V++ + + +L+K LK  + + FE   IIHNAG VGD+SK + +  +  V + +  +N+   + +N    +    + +V          +VN++S C+I+PF SMS YC+ KA REM+F+ LA E    Q L ++ V+NY+PG +DTEM   +   + + EL    +  ++N  ++ P+ +  K F  VL     +K+G  +D+YD
Sbjct:    7 KRTYLFVTGASRGIGQRMSIEVAAKLKPGSIIVLLARSEQGLLNTKESIEALGNNVKVYTYSTDLSLVTATQFRELLEKSLKGVKISDFERAFIIHNAGTVGDVSKSAVDVSDANVWQQYYYVNVFSVISLNCEFFRVFSGTPKV----------VVNITSKCSIEPFASMSFYCSGKAAREMYFRVLATE----QALDNVVVLNYAPGAIDTEMTEQVQRESTNKELVGLFKKQRDNKTMLTPEQTTAK-FLQVLQE-QKFKTGDHVDYYD 262
[Close]
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A0L0C4Y7 (Uncharacterized protein OS=Lucilia cuprina OX=7375 GN=FF38_08597 PE=4 SV=1)

HSP 1 Score: 151.369 bits (381), Expect = 4.140e-40
Identity = 89/274 (32.48%), Postives = 149/274 (54.38%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSIL-DKILKLYE--TQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            KK    ITGA RG G++ A+   K  + +S++++  RNE  L +TK  +E+  + ++V  + LDL    +++ + +L D +LK  E    FE   IIHNAG VGD+SK + +  + +V   + + N+  T+ +N    K      +          L+VN+SS C I+PF SMS YC+ KA R M+F  LA E    ++  D  V+NY+PG +DT+M  Y+ D   S EL    +  ++   ++  + +  K F ++L     ++SG+ +D++D
Sbjct:    7 KKTYFLITGASRGIGKTMAIEVSKLLKTDSVIVLIARNEDGLKKTKGSIESERSDLKVVTYSLDLSIAKAEDFQKLLTDSLLKSKEKINNFERAFIIHNAGTVGDVSKKAIDVSDTKVWTQYFHTNVFSTISLNVEFFKMFAFVPK----------LVVNISSKCGIEPFASMSFYCSGKAARNMYFGVLAAE----EKDNDTIVLNYAPGAIDTDMTVYVQDATISKELHDVFKSQRDTKTMLTTEKTTAK-FLSILKE-QKFESGAHVDYWD 264
[Close]
BLAST of Sepiapterin reductase vs. TrEMBL
Match: A0A1I8Q868 (Uncharacterized protein OS=Stomoxys calcitrans OX=35570 GN=106087827 PE=4 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 3.021e-39
Identity = 90/276 (32.61%), Postives = 152/276 (55.07%), Query Frame = 3 
Query:  105 KKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF---VIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLI--LLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            KK    ITGA RG G+S AL      +  S++++  RN   L +TK  +E+  + + V+V  +DL T  + + + I+   L   + +   F    IIHNAG +GD+++ + E  E  +   + + N+  T+ +N    K              P +  L+VN+SSLC+I+PF SMS+YC+ KA REM+F+ LAVE    ++  D  V+NY+PG +DT+M   + +++ + +L    +  ++N  ++    +AEK F  VL   S +++G+ ID+YD
Sbjct:    5 KKTFFLITGASRGIGKSMALEIASKLKAGSVILLMARNLEALQKTKSEIESKRSDVTVQVISIDLSTAKTVQFQKIISGSLVQSQQEVSSFDRAFIIHNAGTLGDVTRKAQEMGETELWTQYYHTNVFATIALNVEFFKVF------------PTVPKLVVNISSLCSIEPFISMSLYCSGKAAREMYFKVLAVE----EKDNDTLVLNYAPGAIDTDMTMIIQEDSFNLDLQDAFKTQRDNRTMLTTQQTAEK-FIKVLEEVS-FETGAHIDYYD 262
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Cavefish
Match: spra (sepiapterin reductase [Source:NCBI gene;Acc:103045273])

HSP 1 Score: 129.798 bits (325), Expect = 2.569e-35
Identity = 83/284 (29.23%), Postives = 149/284 (52.46%), Query Frame = 3 
Query:   78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKL--LETKLLV-ETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920
            M+ + E    + L  ITGA +GFG S A       +  S+L++  R+  KL  L+  L   E  +A ++V     DL     + ++S++ +  +      +  ++ +NA ++GD+S+ +  F +   ++S+ + N++  + + + +L      + +++        +VNVSSLCA++PF S  MYC  KA R+M F+ LA E       P+L V+NY+PGP+DT+M       +A + +      + E G+L+  + S  KL   +L +  +Y SG+ +DFYDL
Sbjct:    1 MASSQEKGFGRALCIITGASKGFGWSLAREIAPLLKPGSVLLLAARSGDKLQTLQADLAASEASSAGLQVRCVVADLG--QKEGVESVIAEAKETRCEDIDHLLLFNNAASLGDISRYAQSFTDMSEMDSYLSFNVSSALSLTSGILTAFPQRSGLQRC-------VVNVSSLCAVKPFRSWVMYCTGKAARDMMFRVLAEEE------PELRVLNYAPGPLDTDMQLQARSTSADENMRKSFADMHEEGRLLTCEESVAKLLKVLLED--DYPSGTHLDFYDL 267
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Nematostella
Match: EDO46442 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ68])

HSP 1 Score: 107.457 bits (267), Expect = 2.140e-27
Identity = 74/269 (27.51%), Postives = 139/269 (51.67%), Query Frame = 3 
Query:  123 ITGAGRGFGRSCALVAGKFFEN---ESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILK-LYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYD 917
            ITGA RG G   A+   +  +    E   I+  RN+  L +T   V  + + I+  +   DL  +  D ++ +LD I + +  + F   ++++NAG++GDLS+   +F +   ++ +  +N+T   I+ +  + E + +             + N+SSL AIQ ++  S+YC  KA R+M    LA E +      D+ ++NY+PGP+DT+M   + + + + E+   +      G ++ P  S++KL   +L +   YKSG+ +D++D
Sbjct:   12 ITGASRGLGCCIAVSIAEVAQAQNCEVTFILVARNKEGLEKTLNQVRQVKSSIKGFLIVGDLGKL--DTLQGLLDDIFQCVTPSAFSHSLLVNNAGSLGDLSRPMKDFTDPDEVQQYMGLNLTSPFIIASRFVNEFKSTKR----------YIANISSLMAIQAWKGFSLYCVGKASRDMAHSVLATEED------DVRILNYAPGPLDTDMNNIIQEWSYNQEVKQML----NKGNVLRPKQSSDKLVQILLDD--TYKSGAHLDYFD 256
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Nematostella
Match: EDO41444 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4B0])

HSP 1 Score: 46.595 bits (109), Expect = 5.675e-6
Identity = 51/219 (23.29%), Postives = 101/219 (46.12%), Query Frame = 3 
Query:   93 ELKMKKNLIFITGAGRGFGRSCA-LVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEM 746
            +LK   +   +TG   G GR  A  +AG+       +++  R+  KL + +  +E+  + ++ ++   D     + E+   LD+ L    +  +  ++++N G    +++  +  ++  V     N+N    V++ +++L  +           +   ++VNVSSL    P   MS+YCA KAF + F  CL  E+ +K     +FV    P  + T+M
Sbjct:   46 DLKRYGSWAVVTGCTDGIGRCYAEKLAGRGLN----IVLISRSLEKLKQVQQHIESQFS-VQTKIIVKDFG--GNAEVYQDLDEQL----SNLDIGILVNNVGMASMINR--FADLKIEVCWKMLNVNALSAVMMTHIVLPGML---------SRQRGVVVNVSSLVGSDPMPLMSVYCATKAFLDFFSSCLHSEYSSK----GIFVQCVRPAFVATKM 238
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Medaka
Match: spra (sepiapterin reductase [Source:NCBI gene;Acc:110015794])

HSP 1 Score: 133.265 bits (334), Expect = 1.044e-36
Identity = 83/276 (30.07%), Postives = 149/276 (53.99%), Query Frame = 3 
Query:  102 MKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGR--NERKLLETKLL-VETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920
            + + L  ITGA RGFGR+ A    +  +  S+L++  R  +E + L+ +L   E   A ++V+V   D+    ++ +++I+    + +    +  ++I+NA ++GD+S+ +  F +   ++S+ ++N++ ++ +   +L+       +R         +VNV+SLCA+QPF S  +YC  KA REM F+ LA E       P+L V+NYSPGP+DTEM        A  ++      +K  G+L+  + S  KL   +L +   + SG+ ID YD+
Sbjct:    7 LGRALCIITGASRGFGRAVARDLSRLVQPGSVLVLAARSGDELRALQAELTDSEAGRAGLKVQVAVADVG--RTEGLEAIIRSSAEAFSENIDRVILINNAASLGDVSRFTRSFTDMAEVDSYLSLNVSSSLCLTARVLQAFPGRGGLRHT-------VVNVTSLCALQPFRSWVLYCTGKAAREMMFRVLAEEE------PELRVLNYSPGPLDTEMQQEARSRTADPDVKIAFSDMKTRGQLLTCEESCAKLMKVLLED--GFSSGAHIDVYDV 265
[Close]
BLAST of Sepiapterin reductase vs. Ensembl Medaka
Match: dhrs7b (dehydrogenase/reductase 7B [Source:NCBI gene;Acc:101157135])

HSP 1 Score: 57.3806 bits (137), Expect = 5.723e-9
Identity = 57/219 (26.03%), Postives = 95/219 (43.38%), Query Frame = 3 
Query:  114 LIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLD---LETVSSDEIKSILDKILKLYETQFECFVIIHNAG-----NVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEM 746
            ++ ITGA  G G+ CA V   F    + L++CGR+  +L +    +       + + F       +   +D I    ++ILK Y       V+I+NAG     N+ D    ++  ++R V+E+    N  G + +   LL  + H    R++       +V +SS+       S S Y A K   + FF CL  E E       + V   SPG + T++
Sbjct:   35 VVVITGASSGLGKECARV---FHAAGARLVVCGRDAGRLQQVVQELTASTTATQKQTFSPSTVIFDLAKADTIGKAAEEILKCYG---HVDVLINNAGISYRGNILD----THISVQREVMET----NYFGPISLTQALLPSMVH----RRSGH-----IVVISSVQGKIAIPSRSAYAASKHATQAFFDCLRAEIEQN----GISVTVISPGYIQTDL 226
[Close]
BLAST of Sepiapterin reductase vs. Planmine SMEST
Match: SMESG000026493.1 (SMESG000026493.1)

HSP 1 Score: 565.459 bits (1456), Expect = 0.000e+0
Identity = 276/281 (98.22%), Postives = 277/281 (98.58%), Query Frame = 3 
Query:   78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYSNYKSGSRIDFYDL 920
            MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKL ETQFECFVIIHNAGNVGDLSKCSYEFMER+VIESFTNINMTGTVIVNNVLLKEI HSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLF INYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANY NYKSGSRIDFYDL
Sbjct:    1 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLSETQFECFVIIHNAGNVGDLSKCSYEFMERKVIESFTNINMTGTVIVNNVLLKEISHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFAINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLINPDNSAEKLFYNVLANYFNYKSGSRIDFYDL 281
[Close]
BLAST of Sepiapterin reductase vs. Planmine SMEST
Match: SMESG000079254.1 (SMESG000079254.1)

HSP 1 Score: 58.151 bits (139), Expect = 1.309e-9
Identity = 64/219 (29.22%), Postives = 103/219 (47.03%), Query Frame = 3 
Query:   78 MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVE--TMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPG 728
            M   + L  K  LI  TGA  G G+S A +   FF+  + ++I GRN   L +T  L E   +N   R+  F  DL   + +++K + +K L     +F    I+ N  N G +S  + E +E    +S  N+N+   + + N+L   +      RK +      +VNVSS+   + F ++  YC  KA  E F +C A++  +K     + V   SPG
Sbjct:    1 MIHKFSLNFKNALI--TGASSGIGKSTAEL---FFKLGANILITGRNLENLNDTIKLCELSKVNENQRIVAFTADL--TNEEDVKKLAEKTL----LEFPKLDILIN--NAGVISNDTIENVEMENFDSVMNMNLRSVIQLTNLLSPSLID----RKGS------IVNVSSVAGTRAFPNVMSYCISKAALEQFTKCTALDLASK----GVRVNAVSPG 192
[Close]
BLAST of Sepiapterin reductase vs. Planmine SMEST
Match: SMESG000079251.1 (SMESG000079251.1)

HSP 1 Score: 57.7658 bits (138), Expect = 2.070e-9
Identity = 60/239 (25.10%), Postives = 111/239 (46.44%), Query Frame = 3 
Query:  120 FITGAGRGFGRSCALVAGKFFENESLLIICGRNERKLLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECFVIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHSTEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEWEAKQRLPDLFVINYSPGPMDTEMMAYL-IDNAASDELTSQMRILKENGKLINP 833
             ITGA  G GR+ A +   FF+  + L+I GRN+  L +T LL E    +   ++     +  + D+I+ + +K L  +  Q +  ++I+NA   G L   + E +     +   N+N+   + + ++L      +  + KA       +VNVSS+   + F  +  YC  KA  + F +C A++   K     + V   +PG + T++     +D +A  E   + ++    G+  NP
Sbjct:   12 LITGASSGVGRATADL---FFQLGANLVITGRNDDNLKDTALLCEKHRVMENQKLVMFLADLANEDDIRKLAEKTLSEF-VQLD--ILINNA---GILLNDTIETVSMDQFDMNINLNLRAVIQLTHLL------TPSLIKAKGS----IVNVSSVAGSKSFPGIMSYCIGKAGLDQFTRCAALDLAKK----GVRVNAVNPGVILTDIHKRAGMDESAYQEFLQRAQLTHALGRFGNP 227
The following BLAST results are available for this feature:
BLAST of Sepiapterin reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
SPR1.257e-3830.07sepiapterin reductase [Source:HGNC Symbol;Acc:HGNC... [more]
DHRS7B4.249e-726.94dehydrogenase/reductase 7B [Source:HGNC Symbol;Acc... [more]
DHRS7B4.856e-726.94dehydrogenase/reductase 7B [Source:HGNC Symbol;Acc... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dhs-211.066e-823.90L-xylulose reductase [Source:UniProtKB/Swiss-Prot... [more]
Y47G6A.212.722e-625.00pep chromosome:WBcel235:I:3551949:3559807:-1 gene:... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sptr2.461e-3731.62gene:FBgn0014032 transcript:FBtr0071241[more]
CG121168.493e-1124.10gene:FBgn0030041 transcript:FBtr0071240[more]
CG315491.180e-927.07gene:FBgn0051549 transcript:FBtr0078707[more]
CG315491.180e-927.07gene:FBgn0051549 transcript:FBtr0335215[more]
CG121715.038e-725.93gene:FBgn0037354 transcript:FBtr0078708[more]
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BLAST of Sepiapterin reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
spra8.985e-3931.37sepiapterin reductase a [Source:ZFIN;Acc:ZDB-GENE-... [more]
sprb3.276e-3527.54sepiapterin reductase b [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dock81.257e-2634.48dedicator of cytokinesis 8 [Source:Xenbase;Acc:XB-... [more]
gria41.255e-724.79glutamate receptor, ionotropic, AMPA 4 [Source:Xen... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Spr2.683e-3629.32sepiapterin reductase [Source:MGI Symbol;Acc:MGI:1... [more]
Spr2.683e-3629.32sepiapterin reductase [Source:MGI Symbol;Acc:MGI:1... [more]
Spr7.180e-2425.56sepiapterin reductase [Source:MGI Symbol;Acc:MGI:1... [more]
Dhrs7b1.583e-727.06dehydrogenase/reductase (SDR family) member 7B [So... [more]
Dhrs7b1.743e-727.06dehydrogenase/reductase (SDR family) member 7B [So... [more]
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BLAST of Sepiapterin reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q17QK8|SPRE_BOVIN2.082e-3831.27Sepiapterin reductase OS=Bos taurus OX=9913 GN=SPR... [more]
sp|P35270|SPRE_HUMAN6.037e-3830.07Sepiapterin reductase OS=Homo sapiens OX=9606 GN=S... [more]
sp|P18297|SPRE_RAT5.469e-3731.09Sepiapterin reductase OS=Rattus norvegicus OX=1011... [more]
sp|Q8R536|SPRE_MERUN7.988e-3630.08Sepiapterin reductase OS=Meriones unguiculatus OX=... [more]
sp|Q64105|SPRE_MOUSE1.647e-3529.32Sepiapterin reductase OS=Mus musculus OX=10090 GN=... [more]
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BLAST of Sepiapterin reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0K8UBL06.253e-4231.99Sepiapterin reductase OS=Bactrocera latifrons OX=1... [more]
A0A034UZ411.347e-4131.62Sepiapterin reductase OS=Bactrocera dorsalis OX=27... [more]
A0A0C9RNW51.347e-4131.62SPR protein OS=Fopius arisanus OX=64838 GN=SPR PE=... [more]
A0A0L0C4Y74.140e-4032.48Uncharacterized protein OS=Lucilia cuprina OX=7375... [more]
A0A1I8Q8683.021e-3932.61Uncharacterized protein OS=Stomoxys calcitrans OX=... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
spra2.569e-3529.23sepiapterin reductase [Source:NCBI gene;Acc:103045... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sepiapterin reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sepiapterin reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO464422.140e-2727.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO414445.675e-623.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Sepiapterin reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
spra1.044e-3630.07sepiapterin reductase [Source:NCBI gene;Acc:110015... [more]
dhrs7b5.723e-926.03dehydrogenase/reductase 7B [Source:NCBI gene;Acc:1... [more]
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BLAST of Sepiapterin reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000026493.10.000e+098.22SMESG000026493.1[more]
SMESG000079254.11.309e-929.22SMESG000079254.1[more]
SMESG000079251.12.070e-925.10SMESG000079251.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30035504 ID=SMED30035504|Name=Sepiapterin reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=979bp
GATTATTTTCGAACCACATTGATAATAATCATTTCTAAAAACAATATTGA
CATAAAATTAAAGATTAAAATTTGGACATGTCCAAAACCTATGAATTAAA
GATGAAAAAAAATTTAATTTTTATAACTGGAGCAGGAAGAGGATTCGGTC
GGTCTTGTGCATTGGTTGCTGGAAAATTTTTTGAAAACGAATCTTTGTTA
ATTATTTGCGGTAGAAATGAGAGAAAATTGCTCGAGACGAAACTACTTGT
TGAAACTATGAATGCATTAATCAGGGTTGAAGTGTTCAAGCTAGACCTGG
AAACAGTTTCATCTGATGAAATTAAATCAATATTGGATAAAATATTAAAA
TTATACGAAACTCAATTCGAATGTTTTGTGATTATTCACAATGCAGGAAA
CGTGGGTGACCTTAGCAAGTGCAGTTACGAGTTCATGGAGCGAAGAGTAA
TTGAGTCGTTTACAAACATCAATATGACCGGGACTGTGATCGTCAACAAT
GTTTTATTGAAGGAAATTCGCCATTCCACAGAGGTGCGCAAAGCTAATGA
TAAACCTCTCATTCTCCTAGTCAACGTTTCGAGTCTCTGTGCTATACAGC
CGTTTGAATCAATGTCAATGTATTGTGCAATGAAGGCATTTAGGGAGATG
TTTTTCCAATGTCTGGCGGTTGAATGGGAGGCCAAGCAAAGGTTGCCGGA
TCTGTTCGTCATCAACTACTCACCAGGACCCATGGACACGGAAATGATGG
CTTATCTGATCGACAATGCGGCTAGTGACGAACTTACAAGCCAAATGCGC
ATATTGAAAGAAAACGGGAAACTTATCAATCCCGACAATTCCGCTGAGAA
ATTGTTCTACAACGTTCTCGCTAATTATTCCAATTATAAATCCGGATCGA
GAATCGACTTTTATGATTTGTAGAGTCTGATTCCTTATTTTGCTTAATAA
ACTGTTAACTAAATTATATATTTTTTGAG
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protein sequence of SMED30035504-orf-1

>SMED30035504-orf-1 ID=SMED30035504-orf-1|Name=SMED30035504-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=282bp
MSKTYELKMKKNLIFITGAGRGFGRSCALVAGKFFENESLLIICGRNERK
LLETKLLVETMNALIRVEVFKLDLETVSSDEIKSILDKILKLYETQFECF
VIIHNAGNVGDLSKCSYEFMERRVIESFTNINMTGTVIVNNVLLKEIRHS
TEVRKANDKPLILLVNVSSLCAIQPFESMSMYCAMKAFREMFFQCLAVEW
EAKQRLPDLFVINYSPGPMDTEMMAYLIDNAASDELTSQMRILKENGKLI
NPDNSAEKLFYNVLANYSNYKSGSRIDFYDL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
Vocabulary: INTERPRO
TermDefinition
IPR036291NAD(P)-bd_dom_sf
IPR002347SDR_fam
IPR016040NAD(P)-bd_dom
Vocabulary: molecular function
TermDefinition
GO:0004757sepiapterin reductase activity
Vocabulary: biological process
TermDefinition
GO:0006729tetrahydrobiopterin biosynthetic process
GO:0055114oxidation-reduction process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002347Short-chain dehydrogenase/reductase SDRPRINTSPR00081GDHRDHcoord: 97..108
score: 28.26
coord: 182..201
score: 29.21
coord: 207..224
score: 21.97
coord: 13..30
score: 35.08
IPR002347Short-chain dehydrogenase/reductase SDRPFAMPF00106adh_shortcoord: 13..227
e-value: 2.0E-19
score: 69.8
NoneNo IPR availableGENE3DG3DSA:3.40.50.720coord: 8..280
e-value: 5.7E-39
score: 135.9
NoneNo IPR availablePANTHERPTHR44085:SF2SEPIAPTERIN REDUCTASEcoord: 8..280
NoneNo IPR availablePANTHERPTHR44085FAMILY NOT NAMEDcoord: 8..280
IPR036291NAD(P)-binding domain superfamilySUPERFAMILYSSF51735NAD(P)-binding Rossmann-fold domainscoord: 8..274