SMED30035464
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035464 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Alignments
SMED30035464 aligns in the following genomic locations:
Homology
BLAST of SMED30035464 vs. Ensembl Human
Match: LYRM2 (LYR motif containing 2 [Source:HGNC Symbol;Acc:HGNC:25229]) HSP 1 Score: 46.595 bits (109), Expect = 1.044e-6 Identity = 21/71 (29.58%), Postives = 40/71 (56.34%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+RR QV+ +YR+ ++ + + + + + +W R EF+ NK T + I I +G L + E+ +AL+ Sbjct: 16 FVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFRRNKSATEEDTIRMMITQGNMQLKELEKTLALA 86
BLAST of SMED30035464 vs. Ensembl Fly
Match: CG34229 (gene:FBgn0259832 transcript:FBtr0112422) HSP 1 Score: 43.5134 bits (101), Expect = 6.617e-6 Identity = 17/71 (23.94%), Postives = 42/71 (59.15%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+ R +V+ +YR+ + + + D + ++E+ +W R++F+ N+ ++++ I + G + LT+ + LS Sbjct: 14 FMLRQEVLKLYREIFRTIRQVPDKNSQLELKSWARHDFQTNRHQSDEVAIKMLLQHGRRSLTELRTSLQLS 84
BLAST of SMED30035464 vs. Ensembl Xenopus
Match: zswim8 (zinc finger SWIM-type containing 8 [Source:Xenbase;Acc:XB-GENE-1217722]) HSP 1 Score: 47.7506 bits (112), Expect = 3.346e-7 Identity = 22/71 (30.99%), Postives = 38/71 (53.52%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+ R QV+ +YRK ++ + I D + + W R EF+ NK T ++ I I G + L + E+ + L+ Sbjct: 15 FLVRQQVLGLYRKILRSVRQIPDAADQRYMQEWAREEFRRNKGATEEIAIRMMITHGQRQLQELERALHLA 85
BLAST of SMED30035464 vs. Ensembl Mouse
Match: Lyrm2 (LYR motif containing 2 [Source:MGI Symbol;Acc:MGI:1917573]) HSP 1 Score: 48.1358 bits (113), Expect = 2.179e-7 Identity = 23/72 (31.94%), Postives = 40/72 (55.56%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALSS 453 F+RR QV+ +YRK ++ + + + + +W R EFK NK T + I I +G L + E+ +AL++ Sbjct: 16 FMRRQQVLLLYRKILRAIRQVPSDSDRKYLQDWAREEFKRNKSATEEDTIRMMITQGNMQLKELERTLALAN 87
BLAST of SMED30035464 vs. UniProt/SwissProt
Match: sp|B2GV91|LYRM2_RAT (LYR motif-containing protein 2 OS=Rattus norvegicus OX=10116 GN=Lyrm2 PE=3 SV=1) HSP 1 Score: 49.2914 bits (116), Expect = 5.780e-7 Identity = 25/71 (35.21%), Postives = 39/71 (54.93%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+RR QV+ +YRK ++ K I + + +W R EFK NK T + I I +G L + E+ +AL+ Sbjct: 16 FMRRQQVLLLYRKILRAIKQIPSDSDRKYLQDWAREEFKRNKSATEEDTIRMMITQGNMQLKELERTLALA 86
BLAST of SMED30035464 vs. UniProt/SwissProt
Match: sp|Q8R033|LYRM2_MOUSE (LYR motif-containing protein 2 OS=Mus musculus OX=10090 GN=Lyrm2 PE=3 SV=1) HSP 1 Score: 48.1358 bits (113), Expect = 1.524e-6 Identity = 23/72 (31.94%), Postives = 40/72 (55.56%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALSS 453 F+RR QV+ +YRK ++ + + + + +W R EFK NK T + I I +G L + E+ +AL++ Sbjct: 16 FMRRQQVLLLYRKILRAIRQVPSDSDRKYLQDWAREEFKRNKSATEEDTIRMMITQGNMQLKELERTLALAN 87
BLAST of SMED30035464 vs. UniProt/SwissProt
Match: sp|B3DLF3|LYRM2_XENTR (LYR motif-containing protein 2 OS=Xenopus tropicalis OX=8364 GN=lyrm2 PE=3 SV=1) HSP 1 Score: 47.7506 bits (112), Expect = 1.773e-6 Identity = 22/71 (30.99%), Postives = 38/71 (53.52%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+ R QV+ +YRK ++ + I D + + W R EF+ NK T ++ I I G + L + E+ + L+ Sbjct: 15 FLVRQQVLGLYRKILRSVRQIPDAADQRYMQEWAREEFRRNKGATEEIAIRMMITHGQRQLQELERALHLA 85
BLAST of SMED30035464 vs. UniProt/SwissProt
Match: sp|Q5RES3|LYRM2_PONAB (LYR motif-containing protein 2 OS=Pongo abelii OX=9601 GN=LYRM2 PE=3 SV=1) HSP 1 Score: 47.7506 bits (112), Expect = 2.315e-6 Identity = 22/71 (30.99%), Postives = 40/71 (56.34%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+RR QV+ +YR+ ++ + + + + + +W R EFK NK T + I I +G L + E+ +AL+ Sbjct: 16 FVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFKRNKSATEEDTIRMMITQGNMQLKELEKTLALA 86
BLAST of SMED30035464 vs. UniProt/SwissProt
Match: sp|Q32LM5|LYRM2_BOVIN (LYR motif-containing protein 2 OS=Bos taurus OX=9913 GN=LYRM2 PE=3 SV=1) HSP 1 Score: 46.9802 bits (110), Expect = 4.394e-6 Identity = 22/71 (30.99%), Postives = 40/71 (56.34%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+RR QV+ +YR+ ++ + + + + + +W R EFK NK T + I I +G L + E+ +AL+ Sbjct: 16 FMRRQQVLLLYRRILQAIRQVPNDSDRKYLKDWAREEFKRNKSATEEDTIRMMITQGNMQLKELEKTLALA 86
BLAST of SMED30035464 vs. TrEMBL
Match: A0A1S3HHE6 (LYR motif-containing protein 2 OS=Lingula unguis OX=7574 GN=LOC106154917 PE=3 SV=1) HSP 1 Score: 54.299 bits (129), Expect = 2.793e-6 Identity = 23/71 (32.39%), Postives = 41/71 (57.75%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+ R +V+ +YR+F + + + D ++ E+ W+R FK N L ++L I I + K L + E+M+ LS Sbjct: 16 FLLRAEVLKLYRQFGRTLQCVPDKSHRAELQTWVRTGFKQNIGLEDELAIKMCISQAQKQLKELERMLKLS 86
BLAST of SMED30035464 vs. TrEMBL
Match: A0A1Y1W7K8 (Uncharacterized protein OS=Linderina pennispora OX=61395 GN=DL89DRAFT_268218 PE=3 SV=1) HSP 1 Score: 53.9138 bits (128), Expect = 3.331e-6 Identity = 26/65 (40.00%), Postives = 40/65 (61.54%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFE 432 FI+RG+VI+MYRK+M+LTK I D + K E+ WIR +F + T+ I + + T+ + E Sbjct: 23 FIQRGKVIAMYRKYMRLTKRIPDKNDKREMRQWIRGDFDRYRSETDAQKIEVLLAQATRQYKEME 87
BLAST of SMED30035464 vs. TrEMBL
Match: A0A1S4EDP3 (LYR motif-containing protein 2 OS=Diaphorina citri OX=121845 GN=LOC108252589 PE=3 SV=1) HSP 1 Score: 53.5286 bits (127), Expect = 4.485e-6 Identity = 24/70 (34.29%), Postives = 42/70 (60.00%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIAL 447 F+ R +V+ +Y+ F++ K I D + E+ +WIR+EFK NK L+++ I I G + L + E ++L Sbjct: 15 FLLRAEVLGLYKTFLRTAKEIPDESSRKEMIDWIRSEFKHNKHLSDETSIKMMIQYGQRSLKEVESSVSL 84
BLAST of SMED30035464 vs. TrEMBL
Match: A0A2C9KGH6 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106057604 PE=3 SV=1) HSP 1 Score: 53.1434 bits (126), Expect = 4.546e-6 Identity = 26/71 (36.62%), Postives = 41/71 (57.75%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 FI R +V+ +YR F++L+ + D + E+ WIR++F NK T + I AI RG L + EQ I ++ Sbjct: 3 FILRSEVLKLYRSFLRLSYKVEDKARRKELQYWIRSDFDSNKNHTEEEVIKMAISRGKLSLRELEQTIMIA 73
BLAST of SMED30035464 vs. TrEMBL
Match: A0A2J7RRH4 (LYR motif-containing protein 2 OS=Cryptotermes secundus OX=105785 GN=lyrm2 PE=3 SV=1) HSP 1 Score: 53.5286 bits (127), Expect = 4.723e-6 Identity = 24/71 (33.80%), Postives = 40/71 (56.34%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+ R QV+ +YR F++ + + D + E+ W R++FK NK T++ I I G + L Q +Q +A S Sbjct: 15 FMLRQQVLKLYRSFLRAIRDVPDEESRKELLEWARSDFKNNKHHTDEYAIKMLISHGERQLKQLQQNVAFS 85
BLAST of SMED30035464 vs. Ensembl Nematostella
Match: EDO41072 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5E6]) HSP 1 Score: 51.2174 bits (121), Expect = 3.763e-9 Identity = 26/71 (36.62%), Postives = 38/71 (53.52%), Query Frame = 1 Query: 238 FIRRGQVISMYRKFMKLTKTISDPHYKIEISNWIRNEFKGNKKLTNDLDINSAILRGTKMLTQFEQMIALS 450 F+ R QV+ +YR MK I D +++ E+ W R EFK NK T+ I I RG + L + I+L+ Sbjct: 15 FMVRRQVLGLYRDLMKALNKIPDKNHQKELKEWTREEFKQNKTETDPAAIQFMITRGQQALREIASTISLA 85 The following BLAST results are available for this feature:
BLAST of SMED30035464 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of SMED30035464 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of SMED30035464 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of SMED30035464 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of SMED30035464 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of SMED30035464 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 1
BLAST of SMED30035464 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of SMED30035464 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of SMED30035464 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of SMED30035464 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of SMED30035464 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of SMED30035464 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of SMED30035464 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of SMED30035464 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 0
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035464 ID=SMED30035464|Name=SMED30035464|organism=Schmidtea mediterranea sexual|type=transcript|length=616bpback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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