SMED30035436

Overview


Name	SMED30035436
Smed ID	SMED30035436
Length (bp)	2644

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of SMED30035436 (SMED30035436) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30035436 (SMED30035436) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30035436 (SMED30035436) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30035436 (SMED30035436) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30035436

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30035436	h1SMcG0022214	Contig5676	GPL15192	PMID:23079596 Forsthoefel et al., 2012
nervous system	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30035436	h1SMcG0022214	dd_Smed_v4_2773_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of SMED30035436 vs. Ensembl Human
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:HGNC Symbol;Acc:HGNC:29116])

HSP 1 Score: 63.5438 bits (153), Expect = 1.331e-9
Identity = 116/532 (21.80%), Postives = 204/532 (38.35%), Query Frame = 3

Query:  741 SETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPRFL 2315
            S TD  +I TD VDG  D                     + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF     Y+ RF 
Sbjct:  210 SSTD-GSIHTDSVDGTPDP--------------------QRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVVFIAF------LWKHWDALF----SYVERFF 649

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BLAST of SMED30035436 vs. Ensembl Human
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:HGNC Symbol;Acc:HGNC:29116])

HSP 1 Score: 63.1586 bits (152), Expect = 1.416e-9
Identity = 107/495 (21.62%), Postives = 194/495 (39.19%), Query Frame = 3

Query:  852 DIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPRFL 2315
            D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF     Y+ RF 
Sbjct:  112 DPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVVFIAF------LWKHWDALF----SYVERFF 535

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Query:  852 DIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPRFL 2315
            D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF     Y+ RF 
Sbjct:  112 DPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVVFIAF------LWKHWDALF----SYVERFF 535

[Close]

BLAST of SMED30035436 vs. Ensembl Human
Match: TMCC3 (transmembrane and coiled-coil domain family 3 [Source:HGNC Symbol;Acc:HGNC:29199])

HSP 1 Score: 53.5286 bits (127), Expect = 1.296e-6
Identity = 91/439 (20.73%), Postives = 175/439 (39.86%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVK--PADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSACNSRKAGSASATSAISLDQQYGEKASI---PKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSI--QNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSS 2138
            I+D    ++   SL + I    E+I  + + +D  V + +     N  D + + ++ + FE KN+ +  S+ + Q +LEQ   K   + QNG     K    DH+K                     + + +KD   KS +A +   + +S + +    L                + +K+R   +  R     +  GS   I+   NS +     A++     + YG  A+I   PK    +  SSGT                  G  D   N+        ++  Q  ++ +  EL E++    +   + + L++         SQ +Q    R +RLE  L  L    Q E    K +  ++EEK+ Y+     RD+Q+ ++SC   +S +E  + EQ    ++     + K++     N++++ +  I++ +S+
Sbjct:   58 ILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLK--LVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLK--------------------DIHRSLKDAHVKSRTAPHC--MESSKSGMPGVSLTPPVF-----------VFNKSREFANLIR-----NKFGSADNIAHLKNSLEEFRPEASA-----RAYGGSATIVNKPKYGSDDECSSGTS-----------------GSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTV---NAKVLLGRCINVILAFMTVILVCVST 431

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BLAST of SMED30035436 vs. Ensembl Human
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:HGNC Symbol;Acc:HGNC:29116])

HSP 1 Score: 52.7582 bits (125), Expect = 1.387e-6
Identity = 48/210 (22.86%), Postives = 93/210 (44.29%), Query Frame = 3

Query: 1704 SLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPRFL 2315
            +L  E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF     Y+ RF 
Sbjct:  137 ALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVVFIAF------LWKHWDALF----SYVERFF 325

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BLAST of SMED30035436 vs. Ensembl Zebrafish
Match: tmcc1b (transmembrane and coiled-coil domain family 1b [Source:ZFIN;Acc:ZDB-GENE-061013-154])

HSP 1 Score: 59.6918 bits (143), Expect = 1.202e-8
Identity = 92/446 (20.63%), Postives = 181/446 (40.58%), Query Frame = 3

Query:  849 VDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQK-SASAENISRLANSDNNLIASQ------LNKSFIHKHDDVTKSKDILSKTRTLDDTS-------RLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSS 2138
            +D + T+  +  L + I    E+I  + + +D  V + +     N  D + S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   +P D ++                     + + +KD   K +    +IS+  +S    + S+      L ++ +   +++   KD L + +  D  S       R   P     SPK  S   C+S  +GSA A S              P  SK N++  G G                                     +   +L  E+ E++ +  R +   DNL+     +     Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E + +Q   +     +N   + +   L N++++++A +++ +S+
Sbjct:  232 LDPQRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKQQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIPR--QPKDVLR--------------------DMHQGLKDVGAKVTGGLSSISQATHSAAGAVVSKPREFASLIRNKLGSTENIPALKDSLDEQQGDDPVSSTGVAGTRTPGPGQLQSSPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLEHGQG-------------------------------------SGFDTLLHEIQELKDNQSRLEESFDNLKSHYQRDYTDIMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLAVMAVLLVFVST 609

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Query:  849 VDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQK-SASAENISRLANSDNNLIASQ------LNKSFIHKHDDVTKSKDILSKTRTLDDTS-------RLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSS 2138
            +D + T+  +  L + I    E+I  + + +D  V + +     N  D + S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   +P D ++                     + + +KD   K +    +IS+  +S    + S+      L ++ +   +++   KD L + +  D  S       R   P     SPK  S   C+S  +GSA A S              P  SK N++  G G                                     +   +L  E+ E++ +  R +   DNL+     +     Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E + +Q   +     +N   + +   L N++++++A +++ +S+
Sbjct:  232 LDPQRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKQQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIPR--QPKDVLR--------------------DMHQGLKDVGAKVTGGLSSISQATHSAAGAVVSKPREFASLIRNKLGSTENIPALKDSLDEQQGDDPVSSTGVAGTRTPGPGQLQSSPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLEHGQG-------------------------------------SGFDTLLHEIQELKDNQSRLEESFDNLKSHYQRDYTDIMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLAVMAVLLVFVST 609

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Query:  849 VDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQK-SASAENISRLANSDNNLIASQ------LNKSFIHKHDDVTKSKDILSKTRTLDDTS-------RLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSS 2138
            +D + T+  +  L + I    E+I  + + +D  V + +     N  D + S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   +P D ++                     + + +KD   K +    +IS+  +S    + S+      L ++ +   +++   KD L + +  D  S       R   P     SPK  S   C+S  +GSA A S              P  SK N++  G G                                     +   +L  E+ E++ +  R +   DNL+     +     Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E + +Q   +     +N   + +   L N++++++A +++ +S+
Sbjct:  232 LDPQRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKQQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIPR--QPKDVLR--------------------DMHQGLKDVGAKVTGGLSSISQATHSAAGAVVSKPREFASLIRNKLGSTENIPALKDSLDEQQGDDPVSSTGVAGTRTPGPGQLQSSPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLEHGQG-------------------------------------SGFDTLLHEIQELKDNQSRLEESFDNLKSHYQRDYTDIMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLAVMAVLLVFVST 609

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BLAST of SMED30035436 vs. Ensembl Zebrafish
Match: tmcc2 (transmembrane and coiled-coil domain family 2 [Source:ZFIN;Acc:ZDB-GENE-091202-2])

HSP 1 Score: 50.8322 bits (120), Expect = 5.432e-6
Identity = 45/201 (22.39%), Postives = 93/201 (46.27%), Query Frame = 3

Query: 1719 LHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSL----------WHRLCLFLS 2288
            L E++      +   D+++  + ++    +Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ ++SC   ++ +E + +Q   +     +N + + +   L N++++L+A +++ +S+  + +                   P+M T A V A+V L+L          W  LCL  S
Sbjct:  285 LQEIKVGQVHMEDAIDDMKAQLQSDYSYMTQCLQEERYRYERLEEQLNDLTELHQNEMSNLKQELASMEEKVAYQSYERARDIQEAVESCLTRITKLELQQQQQQVVQLEGVENANARALLGKLINVILALMAVLLVFVSTMANFIT------------------PLMKTRARVGATVALALFLVTLWKHWDWLELCLLPS 467

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BLAST of SMED30035436 vs. Ensembl Xenopus
Match: tmcc3 (transmembrane and coiled-coil domain family 3 [Source:NCBI gene;Acc:779714])

HSP 1 Score: 56.225 bits (134), Expect = 1.963e-7
Identity = 45/189 (23.81%), Postives = 88/189 (46.56%), Query Frame = 3

Query: 1692 NDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIML-----------LLSSGFHLLIRVLNIG--ATICRHRNMILPPV 2216
             ++S    EL E++    +   + + L++    +  L SQ +Q    R +RLE  L+ L    Q E    K D  ++EEK+ Y+     RD+Q+ ++SC   +S +E  + EQL   S      + K++     N++++LI  I++           ++ S  H++     +   A +C++ + I+  V
Sbjct:  281 GNLSVFLEELREIKDAQSQLAEDIETLKVHFKRDYSLISQTLQEERYRYERLEDQLNDLTDLHQHETTNLKQDLASIEEKVAYQAYERSRDIQEALESCQTRVSKLELHQQEQLAIQSETV---NAKVLLGKCINILLALITVILVCVSTIAKFVAPMMKSRLHIIFTFFAVTLLAVVCKNWDHIVCAV 466

[Close]

BLAST of SMED30035436 vs. Ensembl Mouse
Match: Tmcc1 (transmembrane and coiled coil domains 1 [Source:MGI Symbol;Acc:MGI:2442368])

HSP 1 Score: 62.003 bits (149), Expect = 2.597e-9
Identity = 105/486 (21.60%), Postives = 191/486 (39.30%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLF 2282
            I D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF
Sbjct:  261 IPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVAFIAF------LWKHWDALF 679

[Close]

BLAST of SMED30035436 vs. Ensembl Mouse
Match: Tmcc1 (transmembrane and coiled coil domains 1 [Source:MGI Symbol;Acc:MGI:2442368])

HSP 1 Score: 62.003 bits (149), Expect = 2.898e-9
Identity = 105/486 (21.60%), Postives = 191/486 (39.30%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLF 2282
            I D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF
Sbjct:  220 IPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVAFIAF------LWKHWDALF 638

[Close]

BLAST of SMED30035436 vs. Ensembl Mouse
Match: Tmcc1 (transmembrane and coiled coil domains 1 [Source:MGI Symbol;Acc:MGI:2442368])

HSP 1 Score: 61.6178 bits (148), Expect = 3.115e-9
Identity = 105/486 (21.60%), Postives = 191/486 (39.30%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLF 2282
            I D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF
Sbjct:   41 IPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVAFIAF------LWKHWDALF 459

[Close]

BLAST of SMED30035436 vs. Ensembl Mouse
Match: Tmcc1 (transmembrane and coiled coil domains 1 [Source:MGI Symbol;Acc:MGI:2442368])

HSP 1 Score: 61.2326 bits (147), Expect = 3.341e-9
Identity = 105/486 (21.60%), Postives = 191/486 (39.30%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLF 2282
            I D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF
Sbjct:   45 IPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVAFIAF------LWKHWDALF 463

[Close]

BLAST of SMED30035436 vs. Ensembl Mouse
Match: Tmcc3 (transmembrane and coiled coil domains 3 [Source:MGI Symbol;Acc:MGI:2442900])

HSP 1 Score: 52.373 bits (124), Expect = 2.403e-6
Identity = 82/392 (20.92%), Postives = 154/392 (39.29%), Query Frame = 3

Query:  978 TNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSACNSRKAGSASATSAISLDQQYGEKASI---PKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSI--QNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSS 2138
             ++ D + + ++ + FE KN+ +  S+ + Q +LEQ   K   + QNG+    K                     K S   +   +KD   KS +A +   L +S +++    L                + +K+R   +  R     +  GS   I+   NS +     A+      + YG  A+I   PK    +  SSGT                  G  D   N+        ++  Q  I+ +  EL E++    +   + + L++         SQ +Q    R +RLE  L  L +  Q E    K +  + EEK+ Y+     RD+Q+ ++SC   +S +E   ++   +   A   + K++     N+V++ +  I++ +S+
Sbjct:  100 VSSADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGVTRSSKDIS------------------KDSLKEIHHSLKDAHVKSRTAPHC--LESSKSSMPGVSLTPPVF-----------VFNKSREFANLIR-----NKFGSADNIAHLKNSLEEFRPEASP-----RAYGGSATIVNKPKYGSDDECSSGTS-----------------GSADSNGNQSFGAGGTSTLDSQGKIAKIMEELREIKVTQTQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTELHQHETANLKQELASAEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQTLQTDA--VNAKVLLGKCINVVLAFMTVILVCVST 431

[Close]

BLAST of SMED30035436 vs. UniProt/SwissProt
Match: sp|O94876|TMCC1_HUMAN (Transmembrane and coiled-coil domains protein 1 OS=Homo sapiens OX=9606 GN=TMCC1 PE=1 SV=3)

HSP 1 Score: 63.5438 bits (153), Expect = 6.390e-9
Identity = 116/532 (21.80%), Postives = 204/532 (38.35%), Query Frame = 3

Query:  741 SETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPRFL 2315
            S TD  +I TD VDG  D                     + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF     Y+ RF 
Sbjct:  210 SSTD-GSIHTDSVDGTPDP--------------------QRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVVFIAF------LWKHWDALF----SYVERFF 649

[Close]

BLAST of SMED30035436 vs. UniProt/SwissProt
Match: sp|Q69ZZ6|TMCC1_MOUSE (Transmembrane and coiled-coil domains protein 1 OS=Mus musculus OX=10090 GN=Tmcc1 PE=1 SV=2)

HSP 1 Score: 62.003 bits (149), Expect = 2.027e-8
Identity = 105/486 (21.60%), Postives = 191/486 (39.30%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-----KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLF 2282
            I D + T+  +  L + I    E+I    + +D  V + +     N+ D + + ++ + FE KN+ + +++ + Q +LE    K   V QNGIP   +P D V     +            S G +      +S  S +  + +    S    IAS +   F    D++   KD L + +  D    L +  +   SPK  S   C+S  +GS  A S        G  A     SK+N++                +S  F  L+                         E+ E+R    R +   + L+     +  L  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E     ++  QL  + N   +N    +   L N++++++A +++ +S+       V N    + + RN     + +   +        LW H   LF
Sbjct:  220 IPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLK--LANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPR--QPKD-VFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF-GSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTT------GGIAVGASSSKTNTLD--------------MQSSGFDALLH------------------------EVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARN----LLGKLINILLAVMAVLLVFVST-------VANCVVPLMKTRNRTFSTLFLVAFIAF------LWKHWDALF 638

[Close]

BLAST of SMED30035436 vs. UniProt/SwissProt
Match: sp|Q9ULS5|TMCC3_HUMAN (Transmembrane and coiled-coil domain protein 3 OS=Homo sapiens OX=9606 GN=TMCC3 PE=1 SV=3)

HSP 1 Score: 53.5286 bits (127), Expect = 6.223e-6
Identity = 91/439 (20.73%), Postives = 175/439 (39.86%), Query Frame = 3

Query:  846 IVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVK--PADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSACNSRKAGSASATSAISLDQQYGEKASI---PKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSI--QNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE-KRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSS 2138
            I+D    ++   SL + I    E+I  + + +D  V + +     N  D + + ++ + FE KN+ +  S+ + Q +LEQ   K   + QNG     K    DH+K                     + + +KD   KS +A +   + +S + +    L                + +K+R   +  R     +  GS   I+   NS +     A++     + YG  A+I   PK    +  SSGT                  G  D   N+        ++  Q  ++ +  EL E++    +   + + L++         SQ +Q    R +RLE  L  L    Q E    K +  ++EEK+ Y+     RD+Q+ ++SC   +S +E  + EQ    ++     + K++     N++++ +  I++ +S+
Sbjct:   58 ILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLK--LVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLK--------------------DIHRSLKDAHVKSRTAPHC--MESSKSGMPGVSLTPPVF-----------VFNKSREFANLIR-----NKFGSADNIAHLKNSLEEFRPEASA-----RAYGGSATIVNKPKYGSDDECSSGTS-----------------GSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTV---NAKVLLGRCINVILAFMTVILVCVST 431

[Close]

BLAST of SMED30035436 vs. TrEMBL
Match: A0A564YRS9 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS8816 PE=4 SV=1)

HSP 1 Score: 100.908 bits (250), Expect = 5.232e-18
Identity = 68/215 (31.63%), Postives = 120/215 (55.81%), Query Frame = 3

Query: 1686 IQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLC------LFLSDSGYLPRF 2312
            I+ +++SL+SEL E R+  +    E D L  DM T  ++ +QK+ +++ R+++L+   + LRQ  Q +  T +++ ++  E L Y+L T  RDL+D   + +N ++++EK  E+L  + +R     ++ I + L +L+VSL+AFI  L+     +LIR LN GAT+  +R ++     +   L   +  LS W   C      +F+ D  YLP F
Sbjct:  549 IKEELNSLRSELTETRNFVNTLTVEVDALTRDMQTKEEVANQKLGDAVARLEQLDASAEKLRQNVQQDLITIRNEQKHALEPLKYQLATETRDLRDMFTTLSNKVTILEK-CERLSNL-DRDQPQMLRSIANTLTDLLVSLVAFITTLI----QMLIRFLNAGATVTNNRALVW---RVHLVLQPMNSVLSCWFTHCTRVSLDVFVLD--YLPMF 752

[Close]

BLAST of SMED30035436 vs. TrEMBL
Match: A0A5K3ENP6 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.316e-17
Identity = 64/214 (29.91%), Postives = 117/214 (54.67%), Query Frame = 3

Query: 1686 IQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALV------IASVKLSLWHRL-CLFLSDSGYLP 2306
            ++ ++++L+ +L E R+  +    E + LR DM T  D+ S  + N+I R+++L+   + LRQ  Q +  + +++ ++  E L Y+L T  RDL+D   + +N ++++EK  E+L  + +R     +++I + + NLVVSL AFI  L+     +LIR LN GAT+  +R   +  V+  C LV      +A      W+R   ++ S   + P
Sbjct:  662 LREELTNLRQDLMETRNMVNTITVEVEALRRDMQTKEDVQSHTLSNAIARLEQLDASAEKLRQNVQQDLISIRNEQKHALEPLKYQLATETRDLRDMFTTLSNKVTIMEK-CERLSNL-DRDQPQALRLIANTMTNLVVSLFAFITALI----QILIRFLNAGATVTNNRVSAI--VLNVCILVFLLVIFLAEPLFRWWNRTDAIYPSSPAFQP 867

[Close]

BLAST of SMED30035436 vs. TrEMBL
Match: A0A5K3EP34 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.696e-17
Identity = 64/214 (29.91%), Postives = 117/214 (54.67%), Query Frame = 3

Query: 1686 IQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALV------IASVKLSLWHRL-CLFLSDSGYLP 2306
            ++ ++++L+ +L E R+  +    E + LR DM T  D+ S  + N+I R+++L+   + LRQ  Q +  + +++ ++  E L Y+L T  RDL+D   + +N ++++EK  E+L  + +R     +++I + + NLVVSL AFI  L+     +LIR LN GAT+  +R   +  V+  C LV      +A      W+R   ++ S   + P
Sbjct:  794 LREELTNLRQDLMETRNMVNTITVEVEALRRDMQTKEDVQSHTLSNAIARLEQLDASAEKLRQNVQQDLISIRNEQKHALEPLKYQLATETRDLRDMFTTLSNKVTIMEK-CERLSNL-DRDQPQALRLIANTMTNLVVSLFAFITALI----QILIRFLNAGATVTNNRVSAI--VLNVCILVFLLVIFLAEPLFRWWNRTDAIYPSSPAFQP 999

[Close]

BLAST of SMED30035436 vs. TrEMBL
Match: A0A5K3EQH6 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 97.0561 bits (240), Expect = 9.051e-17
Identity = 55/170 (32.35%), Postives = 101/170 (59.41%), Query Frame = 3

Query: 1686 IQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHR 2195
            ++ ++++L+ +L E R+  +    E + LR DM T  D+ S  + N+I R+++L+   + LRQ  Q +  + +++ ++  E L Y+L T  RDL+D   + +N ++++EK  E+L  + +R     +++I + + NLVVSL AFI  L+     +LIR LN GAT+  +R
Sbjct:  662 LREELTNLRQDLMETRNMVNTITVEVEALRRDMQTKEDVQSHTLSNAIARLEQLDASAEKLRQNVQQDLISIRNEQKHALEPLKYQLATETRDLRDMFTTLSNKVTIMEK-CERLSNL-DRDQPQALRLIANTMTNLVVSLFAFITALI----QILIRFLNAGATVTNNR 825

[Close]

BLAST of SMED30035436 vs. TrEMBL
Match: A0A4Z2D4A1 (DNA methylase N 6 adenine specific isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_004731 PE=4 SV=1)

HSP 1 Score: 97.0561 bits (240), Expect = 1.049e-16
Identity = 61/213 (28.64%), Postives = 116/213 (54.46%), Query Frame = 3

Query: 1662 NSYSRLF-SIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKI------ITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMIL---PPVMITCALVIASVKLSLWHR 2270
            N  S++F  ++++++ + +E   ++S  +    E + +R D  T ++L +QK+ ++  R++RL+ + +  RQ    E    +++F +    ++Y++TT  RDL DNI S NN +S++EK  +Q    SN  G +  ++      +  +L +L VS  A + +LL     +LIR LN+GA +  +R + +     V+ +C LV  S  + LW R
Sbjct:  780 NQQSQIFQELRDELAVMHNETRSIQSTLNNLTTELEAIRRDATTKAELQNQKLTDASSRIERLDAIAEESRQALPHELAAIRNEFHDSLYSVEYQVTTKIRDLSDNITSINNKVSMIEKPHDQ----SNALGAHGTELDRVRRKVLHYLTDLCVSFFALVTMLL----QVLIRCLNLGAVLTENRKLAVCFSMTVLASCLLVYTSDPIILWLR 984

[Close]

BLAST of SMED30035436 vs. Ensembl Cavefish
Match: tmcc1b (transmembrane and coiled-coil domains protein 1-like [Source:NCBI gene;Acc:103025279])

HSP 1 Score: 63.1586 bits (152), Expect = 9.787e-10
Identity = 104/505 (20.59%), Postives = 205/505 (40.59%), Query Frame = 3

Query:  852 DIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQK-SASAENISRLANSDNNLIASQ------LNKSFIHKHDDVTKSKDILSKTRTLDDT--------SRLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFL 2315
            D + T+  +  L + I    E+I  + + +D  V + +     N  D + S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   +P D ++                     + + +KD   K +     IS+  ++    + S+      L ++     D+++  KD L +T+  D+T        +R++       SPK  S   C+S  +GSA A S   +          P  SK N++  G                           + + +  LF           E+ E+R +  R     ++L+     +  +  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E + +Q   +     +N   + +   L N++++++A +++ +S+       V N    + + R+  L  +++   L        LW    +    S YL RFL
Sbjct:  241 DPQRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKQQSARIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIPR--QPKDVLR--------------------DMHQGLKDVGAKVTGGLSTISQATHTAAGAVVSKPREFASLIRNKFGSADNISALKDSLDETQG-DETISGPGPSGARVLASGQLQSSPKYGSEDDCSSATSGSAGANSTTGV-------PGGPPSSKGNTLEHG---------------------------QSSGFDALF----------HEIQELRENQSRLDESFESLKTHYQKDYTVIMQVLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLAVMAVLLVFVST-------VANCVVPLMKTRSRTLSTLLLVIFLAF------LWRNWEIL---SQYLDRFL 660

[Close]

BLAST of SMED30035436 vs. Ensembl Cavefish
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:NCBI gene;Acc:103027055])

HSP 1 Score: 53.9138 bits (128), Expect = 5.573e-7
Identity = 89/432 (20.60%), Postives = 169/432 (39.12%), Query Frame = 3

Query:  849 VDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSS 2138
            +D + T   +  L + I    E++  + + +D+ V + +   + NT D + S ++ + FE KN+ +  S+ + Q +LE    +       G P   +P D ++ + +  +   +      S G +       S  S +  + +    S    IAS L   F         S D +S  +   D +    P     SPK  S   C+S  +GSA A S              P  SK N+M  G                                         +  L  E+ E+R    R +   + L+     +  +  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E + +Q   +     +N   + +   L N++++L+A +++ +S+
Sbjct:   44 LDPQRTRQAIAQLQQKILKLTEQLRIEQTARDENVAEYL-KLANNTNDKQQSCRIKQVFEKKNQKSAASIAQLQRKLEHYHRRLREAEHGGAPR--QPKDVLRDVQQGLRGVGARVITGISEGVVDSVRGGLSTFSHATHSAAGAVASKPREIASLLRNRF--------GSADNISVLKDGGDEA-CSPPSHLQSSPKFGSEEDCSSATSGSAGANSVTG-------APGGPPSSKGNTMERGR-------------------------------------SGSLEMLLQEVQELREAQARLEETLEGLKSHYQRDYSMVMQALQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSNERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLTLMAVLLVFVST 419

[Close]

BLAST of SMED30035436 vs. Ensembl Cavefish
Match: tmcc3 (transmembrane and coiled-coil domain family 3 [Source:NCBI gene;Acc:103038178])

HSP 1 Score: 53.5286 bits (127), Expect = 6.190e-7
Identity = 48/199 (24.12%), Postives = 90/199 (45.23%), Query Frame = 3

Query: 1716 ELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPR 2309
            E+ EV+        + ++LR  M  N    +Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ ++ C   +S +E + +Q   +   +   D K++     N+++++   I++ +S+            A + R R  IL   +  C L +     S W H  C   ++  +LPR
Sbjct:  273 EVREVKEAQAHLAEDIESLRSQMKRNYGFITQMLQEEKYRCERLEDQLNDLTELHQNETANLKQELASIEEKVAYQAYERARDMQEALEVCQTRISKLELQQQQQQLVQLESA--DAKVLLGKCINIMLAIATVILVCVST-------AAKFTAPLLRSRLHILGTFVCVCVLALG---WSHWEHVQC--AAERMFLPR 457

[Close]

BLAST of SMED30035436 vs. Ensembl Cavefish
Match: tmcc3 (transmembrane and coiled-coil domain family 3 [Source:NCBI gene;Acc:103038178])

HSP 1 Score: 53.5286 bits (127), Expect = 6.694e-7
Identity = 48/199 (24.12%), Postives = 90/199 (45.23%), Query Frame = 3

Query: 1716 ELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPR 2309
            E+ EV+        + ++LR  M  N    +Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ ++ C   +S +E + +Q   +   +   D K++     N+++++   I++ +S+            A + R R  IL   +  C L +     S W H  C   ++  +LPR
Sbjct:  264 EVREVKEAQAHLAEDIESLRSQMKRNYGFITQMLQEEKYRCERLEDQLNDLTELHQNETANLKQELASIEEKVAYQAYERARDMQEALEVCQTRISKLELQQQQQQLVQLESA--DAKVLLGKCINIMLAIATVILVCVST-------AAKFTAPLLRSRLHILGTFVCVCVLALG---WSHWEHVQC--AAERMFLPR 448

[Close]

BLAST of SMED30035436 vs. Ensembl Cavefish
Match: tmcc3 (transmembrane and coiled-coil domain family 3 [Source:NCBI gene;Acc:103038178])

HSP 1 Score: 53.5286 bits (127), Expect = 7.227e-7
Identity = 51/227 (22.47%), Postives = 96/227 (42.29%), Query Frame = 3

Query: 1632 GLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW-HRLCLFLSDSGYLPR 2309
            G +         +SRL     ++  +K     +  D        ++LR  M  N    +Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ ++ C   +S +E + +Q   +   +   D K++     N+++++   I++ +S+            A + R R  IL   +  C L +     S W H  C   ++  +LPR
Sbjct:  277 GAVQSEAGPGEGFSRLADALEEVREVKEAQAHLAEDI-------ESLRSQMKRNYGFITQMLQEEKYRCERLEDQLNDLTELHQNETANLKQELASIEEKVAYQAYERARDMQEALEVCQTRISKLELQQQQQQLVQLESA--DAKVLLGKCINIMLAIATVILVCVST-------AAKFTAPLLRSRLHILGTFVCVCVLALG---WSHWEHVQC--AAERMFLPR 482

[Close]

BLAST of SMED30035436 vs. Ensembl Sea Lamprey
Match: tmcc2 (transmembrane and coiled-coil domain family 2 [Source:ZFIN;Acc:ZDB-GENE-091202-2])

HSP 1 Score: 53.5286 bits (127), Expect = 1.543e-7
Identity = 43/190 (22.63%), Postives = 86/190 (45.26%), Query Frame = 3

Query: 1698 ISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLW 2264
            + +++ ELH + S   R +     +R    T      Q +     R  RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ ++ C   +S +E + +Q   +     +N + + +   L N++++L+A +++ +S+  + +         + R RN IL   ++T  L        LW
Sbjct:  285 MEAIRRELHTIHSTHARLEGMVQEMRTQFQTEVTNFKQSLLEERFRFGRLEDQLNDLTELHQNEMSNLKQELASMEEKVAYQSYERARDVQEALEGCQTRISKLELQQQQQQVVQLEGLENANARALLGKLINVLLALMAVVLVFVSTAANFIT-------PLVRTRNRILVTALLTVMLAY------LW 461

[Close]

BLAST of SMED30035436 vs. Ensembl Medaka
Match: tmcc1b (transmembrane and coiled-coil domains protein 1 [Source:NCBI gene;Acc:101163807])

HSP 1 Score: 56.225 bits (134), Expect = 1.329e-7
Identity = 93/435 (21.38%), Postives = 181/435 (41.61%), Query Frame = 3

Query:  852 DIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDD----TSRLVIPFDNAGSPKVISSA-CNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKN-DVKIITDHLCNLVVSLIAFIMLLLSS 2138
            D + T+  +  L + I    E+I  + + +D  V + +     N  D + S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   +P D  + +++          +K     ++  +  +SQ + SA        S    IAS L   F    D++   KD L +T+  +      SR +       SPK  S   C+S  +GSA A S              P  S+ N++                               D + +  F +      +  E+ E+R +  R +   DNL+     +  +  + +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD Q+ +++C   +S +E + +Q   +     +N   + +   L N++++++A +++ +S+
Sbjct:  231 DPQRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKQQSARIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIPR--QPKDVFRDMHQG---------LKDVGAKVTGGLSSFSQATHSAAGA---VVSKPREIASLLRNKF-GSADNIAALKDSLDETQGDEGVGPGASRNLGTGQLQSSPKYGSEDDCSSATSGSAGANSTPG-------APGGPPSSRVNTL-------------------------------DQAQASGFDV------VLHEIQELRENQSRLEESFDNLKAHYQRDYTMILEALQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDTQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLAVMAVLLVFVST 604

[Close]

BLAST of SMED30035436 vs. Ensembl Medaka
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:NCBI gene;Acc:101171245])

HSP 1 Score: 53.5286 bits (127), Expect = 7.234e-7
Identity = 92/416 (22.12%), Postives = 159/416 (38.22%), Query Frame = 3

Query:  804 VSSG-DSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDIL-----------SKTRTLDDTSRLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE 2012
            VS G D   S       D + T+ ++  L + I    E+I  + + +D  V + +     N  D   S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   + +  V    ++            S G +       S  S +    +    S   +IAS++   F    D++   KD L           +  R+L  T+  ++      SPK  S   C+S  +GSA A S              P  SK N++     + QS                                 + +  L  EL E+R    R +   D L+     +  +  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E
Sbjct:   31 VSCGTDGSFSTAEDGTPDPQRTKQVIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKLQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIP---RHSKDVLRDMQQGLKDVGAKVTGFSEGVVDSVKGGLSSFSQATHTAAGAVVSKPWVIASRIRNKF-GSADNIPSLKDSLDDPSIEEGVTGAGGRSLGSTAHHLLS-----SPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLE----RSQS---------------------------------SSLDMLLQELQELREGQARLEESLDGLKTHYQRDYTVAMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKME 391

[Close]

BLAST of SMED30035436 vs. Ensembl Medaka
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:NCBI gene;Acc:101171245])

HSP 1 Score: 53.9138 bits (128), Expect = 7.809e-7
Identity = 101/458 (22.05%), Postives = 175/458 (38.21%), Query Frame = 3

Query:  681 PMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIV-VSSG-DSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDIL-----------SKTRTLDDTSRLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE 2012
            P   S  +G+      +    ETD+  I   +V G+    + VS G D   S       D + T+ ++  L + I    E+I  + + +D  V + +     N  D   S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   + +  V    ++            S G +       S  S +    +    S   +IAS++   F    D++   KD L           +  R+L  T+  ++      SPK  S   C+S  +GSA A S              P  SK N++     + QS                                 + +  L  EL E+R    R +   D L+     +  +  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E
Sbjct:  199 PGYSSGDVGL---SSGYQSTEETDR--IDRLEVTGLGQTPLNVSCGTDGSFSTAEDGTPDPQRTKQVIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKLQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIP---RHSKDVLRDMQQGLKDVGAKVTGFSEGVVDSVKGGLSSFSQATHTAAGAVVSKPWVIASRIRNKF-GSADNIPSLKDSLDDPSIEEGVTGAGGRSLGSTAHHLLS-----SPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLE----RSQS---------------------------------SSLDMLLQELQELREGQARLEESLDGLKTHYQRDYTVAMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKME 596

[Close]

BLAST of SMED30035436 vs. Ensembl Medaka
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:NCBI gene;Acc:101171245])

HSP 1 Score: 53.5286 bits (127), Expect = 8.253e-7
Identity = 92/416 (22.12%), Postives = 159/416 (38.22%), Query Frame = 3

Query:  804 VSSG-DSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDIL-----------SKTRTLDDTSRLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE 2012
            VS G D   S       D + T+ ++  L + I    E+I  + + +D  V + +     N  D   S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   + +  V    ++            S G +       S  S +    +    S   +IAS++   F    D++   KD L           +  R+L  T+  ++      SPK  S   C+S  +GSA A S              P  SK N++     + QS                                 + +  L  EL E+R    R +   D L+     +  +  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E
Sbjct:   27 VSCGTDGSFSTAEDGTPDPQRTKQVIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKLQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIP---RHSKDVLRDMQQGLKDVGAKVTGFSEGVVDSVKGGLSSFSQATHTAAGAVVSKPWVIASRIRNKF-GSADNIPSLKDSLDDPSIEEGVTGAGGRSLGSTAHHLLS-----SPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLE----RSQS---------------------------------SSLDMLLQELQELREGQARLEESLDGLKTHYQRDYTVAMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKME 387

[Close]

BLAST of SMED30035436 vs. Ensembl Medaka
Match: TMCC1 (transmembrane and coiled-coil domain family 1 [Source:NCBI gene;Acc:101171245])

HSP 1 Score: 52.7582 bits (125), Expect = 1.427e-6
Identity = 92/416 (22.12%), Postives = 159/416 (38.22%), Query Frame = 3

Query:  804 VSSG-DSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDIL-----------SKTRTLDDTSRLVIPFDNAGSPKVISS-ACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVE 2012
            VS G D   S       D + T+ ++  L + I    E+I  + + +D  V + +     N  D   S ++ + FE KN+ + +++++ Q +LE    K   V  NGIP   + +  V    ++            S G +       S  S +    +    S   +IAS++   F    D++   KD L           +  R+L  T+  ++      SPK  S   C+S  +GSA A S              P  SK N++     + QS                                 + +  L  EL E+R    R +   D L+     +  +  Q +Q    R +RLE  L+ L +  Q E    K +  ++EEK+ Y+     RD+Q+ +++C   +S +E
Sbjct:   29 VSCGTDGSFSTAEDGTPDPQRTKQVIAQLQQKILKLTEQIKIEQTARDDNVAEYLK--LANNADKLQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIP---RHSKDVLRDMQQGLKDVGAKVTGFSEGVVDSVKGGLSSFSQATHTAAGAVVSKPWVIASRIRNKF-GSADNIPSLKDSLDDPSIEEGVTGAGGRSLGSTAHHLLS-----SPKYGSEDDCSSATSGSAGANSTTG-------APGGPPSSKGNTLE----RSQS---------------------------------SSLDMLLQELQELREGQARLEESLDGLKTHYQRDYTVAMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKME 389

[Close]

BLAST of SMED30035436 vs. Planmine SMEST
Match: SMESG000022942.1 (SMESG000022942.1)

HSP 1 Score: 1389.02 bits (3594), Expect = 0.000e+0
Identity = 723/729 (99.18%), Postives = 724/729 (99.31%), Query Frame = 3

Query:  132 MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNFIKSPVQKSHNKYKQFQDNDDDNLSAENHSTIEQTAREESIDSKNTDFSTEESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNTNIVVSESPKSDEVXXXXXXXXXXXXXXXEVHQKPMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFLD 2318
            MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNFIKSPVQKSHNKYKQFQDNDDDNLSAENHSTIEQTAREESID KNTDFSTEESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNTNIVVSES KSDEVFDKNSKSKYSSFKNDEVHQKPMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKAS+KLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVKSINKKNKNKKSIPEVKQSPG LSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSK RTLDDTSRLVIPFDNAGSPKVI SACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFLD
Sbjct:    1 MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNFIKSPVQKSHNKYKQFQDNDDDNLSAENHSTIEQTAREESIDFKNTDFSTEESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNTNIVVSESTKSDEVFDKNSKSKYSSFKNDEVHQKPMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASKKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVKSINKKNKNKKSIPEVKQSPGPLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKIRTLDDTSRLVIPFDNAGSPKVILSACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFLD 729

[Close]

BLAST of SMED30035436 vs. Planmine SMEST
Match: SMESG000022942.1 (SMESG000022942.1)

HSP 1 Score: 1360.9 bits (3521), Expect = 0.000e+0
Identity = 722/778 (92.80%), Postives = 724/778 (93.06%), Query Frame = 3

Query:  132 MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNFIKSPVQKSHNKYKQFQDNDDDNLSAENHSTIE-------------------------------------------------QTAREESIDSKNTDFSTEESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNTNIVVSESPKSDEVXXXXXXXXXXXXXXXEVHQKPMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVXXXXXXXXXXXXXPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFLD 2318
            MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNFIKSPVQKSHNKYKQFQDNDDDNLSAENHSTIE                                                 +TAREESID KNTDFSTEESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNTNIVVSES KSDEVFDKNSKSKYSSFKNDEVHQKPMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKAS+KLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVKSINKKNKNKKSIPEVKQSPG LSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSK RTLDDTSRLVIPFDNAGSPKVI SACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFLD
Sbjct:    1 MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNFIKSPVQKSHNKYKQFQDNDDDNLSAENHSTIEHRNHGNRYLAVPYYHCQCNGMKMSESENISIKSFPIEEGLPISENYINYRTAREESIDFKNTDFSTEESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNTNIVVSESTKSDEVFDKNSKSKYSSFKNDEVHQKPMIKSASIGVLFDPKTFGPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQSLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASKKLCKEFEVKNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVKSINKKNKNKKSIPEVKQSPGPLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSFIHKHDDVTKSKDILSKIRTLDDTSRLVIPFDNAGSPKVILSACNSRKAGSASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQGLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLDMNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEKLDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITDHLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCALVIASVKLSLWHRLCLFLSDSGYLPRFLD 778

The following BLAST results are available for this feature:

BLAST of SMED30035436 vs. Ensembl Human
BLAST of SMED30035436 vs. Ensembl Celegans
BLAST of SMED30035436 vs. Ensembl Fly
BLAST of SMED30035436 vs. Ensembl Zebrafish
BLAST of SMED30035436 vs. Ensembl Xenopus
BLAST of SMED30035436 vs. Ensembl Mouse
BLAST of SMED30035436 vs. UniProt/SwissProt
BLAST of SMED30035436 vs. TrEMBL
BLAST of SMED30035436 vs. Ensembl Cavefish
BLAST of SMED30035436 vs. Ensembl Sea Lamprey
BLAST of SMED30035436 vs. Ensembl Yeast
BLAST of SMED30035436 vs. Ensembl Nematostella
BLAST of SMED30035436 vs. Ensembl Medaka
BLAST of SMED30035436 vs. Planmine SMEST

BLAST of SMED30035436 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TMCC1	1.331e-9	21.80	transmembrane and coiled-coil domain family 1 [Sou...	[more]
TMCC1	1.416e-9	21.62	transmembrane and coiled-coil domain family 1 [Sou...	[more]
TMCC1	1.416e-9	21.62	transmembrane and coiled-coil domain family 1 [Sou...	[more]
TMCC3	1.296e-6	20.73	transmembrane and coiled-coil domain family 3 [Sou...	[more]
TMCC1	1.387e-6	22.86	transmembrane and coiled-coil domain family 1 [Sou...	[more]

BLAST of SMED30035436 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of SMED30035436 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of SMED30035436 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
tmcc1b	1.202e-8	20.63	transmembrane and coiled-coil domain family 1b [So...	[more]
tmcc1b	1.202e-8	20.63	transmembrane and coiled-coil domain family 1b [So...	[more]
tmcc1b	1.202e-8	20.63	transmembrane and coiled-coil domain family 1b [So...	[more]
tmcc2	5.432e-6	22.39	transmembrane and coiled-coil domain family 2 [Sou...	[more]

BLAST of SMED30035436 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
tmcc3	1.963e-7	23.81	transmembrane and coiled-coil domain family 3 [Sou...	[more]

BLAST of SMED30035436 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tmcc1	2.597e-9	21.60	transmembrane and coiled coil domains 1 [Source:MG...	[more]
Tmcc1	2.898e-9	21.60	transmembrane and coiled coil domains 1 [Source:MG...	[more]
Tmcc1	3.115e-9	21.60	transmembrane and coiled coil domains 1 [Source:MG...	[more]
Tmcc1	3.341e-9	21.60	transmembrane and coiled coil domains 1 [Source:MG...	[more]
Tmcc3	2.403e-6	20.92	transmembrane and coiled coil domains 3 [Source:MG...	[more]

BLAST of SMED30035436 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3


Match Name	E-value	Identity	Description
sp\|O94876\|TMCC1_HUMAN	6.390e-9	21.80	Transmembrane and coiled-coil domains protein 1 OS...	[more]
sp\|Q69ZZ6\|TMCC1_MOUSE	2.027e-8	21.60	Transmembrane and coiled-coil domains protein 1 OS...	[more]
sp\|Q9ULS5\|TMCC3_HUMAN	6.223e-6	20.73	Transmembrane and coiled-coil domain protein 3 OS=...	[more]

BLAST of SMED30035436 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A564YRS9	5.232e-18	31.63	Uncharacterized protein OS=Hymenolepis diminuta OX...	[more]
A0A5K3ENP6	1.316e-17	29.91	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A5K3EP34	1.696e-17	29.91	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A5K3EQH6	9.051e-17	32.35	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A4Z2D4A1	1.049e-16	28.64	DNA methylase N 6 adenine specific isoform 2 OS=Sc...	[more]

BLAST of SMED30035436 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tmcc1b	9.787e-10	20.59	transmembrane and coiled-coil domains protein 1-li...	[more]
TMCC1	5.573e-7	20.60	transmembrane and coiled-coil domain family 1 [Sou...	[more]
tmcc3	6.190e-7	24.12	transmembrane and coiled-coil domain family 3 [Sou...	[more]
tmcc3	6.694e-7	24.12	transmembrane and coiled-coil domain family 3 [Sou...	[more]
tmcc3	7.227e-7	22.47	transmembrane and coiled-coil domain family 3 [Sou...	[more]

BLAST of SMED30035436 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
tmcc2	1.543e-7	22.63	transmembrane and coiled-coil domain family 2 [Sou...	[more]

BLAST of SMED30035436 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of SMED30035436 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of SMED30035436 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tmcc1b	1.329e-7	21.38	transmembrane and coiled-coil domains protein 1 [S...	[more]
TMCC1	7.234e-7	22.12	transmembrane and coiled-coil domain family 1 [Sou...	[more]
TMCC1	7.809e-7	22.05	transmembrane and coiled-coil domain family 1 [Sou...	[more]
TMCC1	8.253e-7	22.12	transmembrane and coiled-coil domain family 1 [Sou...	[more]
TMCC1	1.427e-6	22.12	transmembrane and coiled-coil domain family 1 [Sou...	[more]

BLAST of SMED30035436 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000022942.1	0.000e+0	99.18	SMESG000022942.1	[more]
SMESG000022942.1	0.000e+0	92.80	SMESG000022942.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30035436 ID=SMED30035436|Name=SMED30035436|organism=Schmidtea mediterranea sexual|type=transcript|length=2644bp
TTAACTAAATCTTTACTTAATAGTATTTTTTAAATAATTTATTTTTATTT
CGCAATTTCGCTTAATCTTTAGTAGAAAATAAGTCGTTTTCTGTAAATAA
TTATTGATTCGTGTATCAGTTTATTGAGCATATGTCATTTTCTCAAAAAA
AGAAACGTTCAATTCTTCCAATAGCTGGGGGGTACATAGAAGAAGAAGTA
GTTTTAGAAACTCAGAAGCCGAGAACTAATAAATCATTGTTGGATTTCAA
ATCACCAAAGTTGAACCGTTTGAAAAACTTTATAAAATCTCCTGTACAAA
AATCACATAACAAATACAAACAGTTTCAAGATAATGACGATGACAATTTA
TCAGCCGAAAATCATTCTACAATTGAACAGACTGCGAGAGAGGAATCGAT
TGATTCCAAAAATACTGACTTTTCCACAGAAGAATCCGCAGCTAATCATG
AAAGTAAAGATATTTCACAAACATCTTTATTAACCGCAATCTCAATAGTA
CCTCCTGAAAATTTTCCAAAATCCGACTTTGATTCAGTAAGTGGTCGAAG
ATCAACATTTGGTGAAATGAGTTTAAATACTAATATTGTCGTTTCGGAAA
GCCCAAAATCCGATGAAGTATTTGATAAGAATTCTAAATCAAAATACAGT
TCATTTAAAAATGATGAAGTACATCAAAAACCTATGATCAAATCTGCTTC
GATTGGAGTACTTTTCGATCCAAAGACATTTGGTCCAAATTCGGAAACAG
ATAAAAATGCAATCGCAACTGATAAAGTTGACGGAGTTAATGATAATATT
GTCGTTTCGTCTGGCGATAGTAAAATATCTCGATGGAATCCAACAATTGT
CGATATTGAAACCACAGAAATCATGCTTCAATCTCTGGATGAACATATCA
AAAATGCAAAAGAGAAAATTCTAAAAGATCTCTCAGTCAAAGATCAAATG
GTCGATAAACTGATTACAAATTTTTCCACCAACACTCCAGATAACAAAGC
TTCAAGAAAGCTCTGTAAAGAATTTGAAGTGAAAAATAAAAACGCCGAAA
AATCTCTCGAAAAGTCTCAAATGGAATTAGAACAATTAGAATACAAGAGA
CTATTAGTGAGTCAAAATGGTATTCCGTGGGGAGTTAAACCAGCTGATCA
TGTCAAAAGCATTAATAAGAAAAATAAAAATAAAAAATCCATTCCAGAAG
TCAAACAGAGTCCAGGGTCTCTTTCAAAATTTATCAAAGATTATTCTCAA
AAATCAGCAAGTGCCGAAAATATTAGTAGACTTGCTAATTCCGATAATAA
TTTGATAGCAAGCCAATTAAACAAATCATTTATTCATAAACATGATGATG
TGACAAAATCCAAAGATATTTTATCAAAAACAAGGACATTAGACGACACA
TCACGACTCGTAATTCCTTTCGATAATGCAGGCTCACCGAAAGTAATTTC
ATCAGCTTGCAACTCAAGGAAAGCAGGATCGGCTAGTGCAACTAGTGCTA
TATCGCTGGATCAACAATATGGTGAGAAAGCTAGCATTCCAAAGAAAAGT
AAATCCAACTCAATGTCTAGCGGTACAGGGAAAGATCAATCGCATGAACA
TGCTGATATTCACGAATCCCCAAAATTTCAAGGTCTCATTGATGAAGGTA
AAAATGAGGATAATTCATATTCACGTCTGTTTTCAATTCAAAATGACATT
AGTTCTCTTAAAAGTGAATTGCATGAAGTTCGTTCGGATTTCCATCGGTT
TCAGTGTGAAGCAGACAATTTAAGATTGGACATGAATACGAATTCAGATT
TGAATTCTCAGAAAATGCAAAATTCTATTGAAAGAGTAGACAGATTAGAG
AGAATGTTAGACTTGCTACGACAGCAGTGCCAAATTGAATTTTGTACATG
GAAAGATGACTTTAGAAATTTGGAAGAGAAGCTTGATTATAGGCTAACCA
CGACTCGTAGGGATCTCCAGGATAACATTGATTCCTGCAATAATAGTTTA
AGTCTGGTTGAGAAGAGAACAGAACAGCTCCCTTTCATTTCTAATAGAGC
CGGGAAAAATGATGTGAAAATAATTACCGATCATTTGTGTAATTTAGTCG
TTTCCTTAATTGCGTTCATTATGCTCTTGCTGTCCTCTGGATTTCACCTG
TTAATCCGAGTGCTAAATATCGGGGCAACAATTTGCCGTCACAGAAACAT
GATCTTGCCCCCTGTGATGATAACGTGCGCCTTGGTTATTGCCTCAGTCA
AACTGTCTCTCTGGCATCGATTGTGCCTCTTTCTCTCAGACTCGGGATAT
CTGCCGAGGTTCCTCGACGGATCCTGACGAGGATCAGTTTAACAGCGCCG
ATCATGATTAATATATATTGATACTTTATAATTGCCATTGTAATTATTTT
TGTATAAATTTATTTGTTCCTTTCAAGATGTTATCAATTATATTTCGATT
TGGTTTGATTTTATCGGAAATCTGGTTTTTGTTGTTTTATTGATTTATTA
AACTTTAGCAGCACATTTGATAATCAGGATTTATGAGCAATTATTATTTA
TTGATTCATTTTCAATTACAATTACTTATCAGGTCAATTAATCAATTACT
AATATCGATTATTTGTGTCGGGTTTTATTTTGGTTTTATGCTAG

protein sequence of SMED30035436-orf-1

>SMED30035436-orf-1 ID=SMED30035436-orf-1|Name=SMED30035436-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=732bp
MSFSQKKKRSILPIAGGYIEEEVVLETQKPRTNKSLLDFKSPKLNRLKNF
IKSPVQKSHNKYKQFQDNDDDNLSAENHSTIEQTAREESIDSKNTDFSTE
ESAANHESKDISQTSLLTAISIVPPENFPKSDFDSVSGRRSTFGEMSLNT
NIVVSESPKSDEVFDKNSKSKYSSFKNDEVHQKPMIKSASIGVLFDPKTF
GPNSETDKNAIATDKVDGVNDNIVVSSGDSKISRWNPTIVDIETTEIMLQ
SLDEHIKNAKEKILKDLSVKDQMVDKLITNFSTNTPDNKASRKLCKEFEV
KNKNAEKSLEKSQMELEQLEYKRLLVSQNGIPWGVKPADHVKSINKKNKN
KKSIPEVKQSPGSLSKFIKDYSQKSASAENISRLANSDNNLIASQLNKSF
IHKHDDVTKSKDILSKTRTLDDTSRLVIPFDNAGSPKVISSACNSRKAGS
ASATSAISLDQQYGEKASIPKKSKSNSMSSGTGKDQSHEHADIHESPKFQ
GLIDEGKNEDNSYSRLFSIQNDISSLKSELHEVRSDFHRFQCEADNLRLD
MNTNSDLNSQKMQNSIERVDRLERMLDLLRQQCQIEFCTWKDDFRNLEEK
LDYRLTTTRRDLQDNIDSCNNSLSLVEKRTEQLPFISNRAGKNDVKIITD
HLCNLVVSLIAFIMLLLSSGFHLLIRVLNIGATICRHRNMILPPVMITCA
LVIASVKLSLWHRLCLFLSDSGYLPRFLDGS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR019394	TEX28/TMCC

Vocabulary: **molecular function**
Term	Definition
GO:0008168	methyltransferase activity

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **biological process**
Term	Definition
GO:0032259	methylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 562..582
None	No IPR available	COILS	Coil	Coil	coord: 242..262
None	No IPR available	COILS	Coil	Coil	coord: 609..629
None	No IPR available	COILS	Coil	Coil	coord: 295..322
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 460..484
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 460..500
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 485..500
None	No IPR available	PANTHER	PTHR17613:SF14	DEMENTIN, ISOFORM H	coord: 243..674
None	No IPR available	TMHMM	TMhelix		coord: 690..712
None	No IPR available	TMHMM	TMhelix		coord: 656..678
IPR019394	Testis-specific protein TEX28/transmembrane and coiled-coil domains protein	PFAM	PF10267	Tmemb_cc2	coord: 248..703 e-value: 5.2E-21 score: 75.2
IPR019394	Testis-specific protein TEX28/transmembrane and coiled-coil domains protein	PANTHER	PTHR17613	CEREBRAL PROTEIN-11-RELATED	coord: 243..674

Main menu

SMED30035436

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Owlery

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