NLK-1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035424 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 24Note: Hover over icons to view figure legend
Homology
BLAST of NLK-1 vs. Ensembl Human
Match: NLK (nemo like kinase [Source:HGNC Symbol;Acc:HGNC:29858]) HSP 1 Score: 414.846 bits (1065), Expect = 3.916e-137 Identity = 201/392 (51.28%), Postives = 276/392 (70.41%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTN 1739
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P +
Sbjct: 89 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPS 470
BLAST of NLK-1 vs. Ensembl Human
Match: NLK (nemo like kinase [Source:HGNC Symbol;Acc:HGNC:29858]) HSP 1 Score: 416.772 bits (1070), Expect = 4.875e-137 Identity = 201/390 (51.54%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. Ensembl Human
Match: MAPK3 (mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877]) HSP 1 Score: 236.113 bits (601), Expect = 2.536e-70 Identity = 130/288 (45.14%), Postives = 187/288 (64.93%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKR--NISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL +HEN+I + DI+++ ++YI+ D M+TDL+K++ S Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLARI D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+ S K AK +AL LLD ML FNP+ RI+ EEAL+H YL+
Sbjct: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY-CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV--AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331
BLAST of NLK-1 vs. Ensembl Human
Match: MAPK3 (mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877]) HSP 1 Score: 236.113 bits (601), Expect = 4.986e-70 Identity = 130/288 (45.14%), Postives = 187/288 (64.93%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKR--NISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL +HEN+I + DI+++ ++YI+ D M+TDL+K++ S Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLARI D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+ S K AK +AL LLD ML FNP+ RI+ EEAL+H YL+
Sbjct: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY-CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV--AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331
BLAST of NLK-1 vs. Ensembl Human
Match: MAPK7 (mitogen-activated protein kinase 7 [Source:HGNC Symbol;Acc:HGNC:6880]) HSP 1 Score: 245.743 bits (626), Expect = 2.041e-69 Identity = 145/383 (37.86%), Postives = 202/383 (52.74%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISP------LTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTP-PLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSN---NVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQ-----KDQYRLRLVLNP 1673
+G GA+GVV S T ++ A+K+IPN F AKR REL IL H KH+NII++ DI++ + +Y++ D M++DLH+II S Q L+++HV+ FLYQ+LRG+KY+HSA +IHRD+KP N+LVN NC LKI DFG+AR SP +T+ V T++YRAPEL++ Y A+D+WS+GC F E+L RR LF K + QL LI+ ++GTP P R Y+ S ++P W +AL LL ML+F P RIS+ AL H +L +YH D EP C P D KE I I++++ + Q R + L P
Sbjct: 61 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR---GLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP-----VPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL----AKYHDP------------------------DDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQP 407
BLAST of NLK-1 vs. Ensembl Celegans
Match: lit-1 (Serine/threonine kinase NLK [Source:UniProtKB/Swiss-Prot;Acc:Q9U9Y8]) HSP 1 Score: 402.519 bits (1033), Expect = 3.347e-133 Identity = 205/425 (48.24%), Postives = 291/425 (68.47%), Query Frame = 3
Query: 489 AVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWS--NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMS--EAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
A++ A Y P + +++ + RP+GYGAFGVVWSV DPR+ K+ ALK++PN+F N + KR++RE+ +LS +H+N++SL+DI++ + E+Y+L + MQ+DLHKIIVSPQAL+ DHVK+F+YQILRG+KYLH+A+I+HRDIKPGN+LVNSNC+LKICDFGLAR D+R+ +T EVVTQYYRAPELLM + Y AVD+WS+GC FAELL R+ILFQA GP+EQL +I++++GTP + +A A+ +VL + P+ + K + ++ EA+ LL +L F+PD RIS EEAL H YL++ RLR+HSCMCSCC+ +KPN R F D +P P + +++S E +E + +F+ + + Y + L +NP S Y+ +SSVAQA E P+ W
Sbjct: 27 AILAAAQPFYPPPVQDSQPD------RPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCY-----TKPNMP-SRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMD--RPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 437
BLAST of NLK-1 vs. Ensembl Celegans
Match: lit-1 (Serine/threonine kinase NLK [Source:UniProtKB/Swiss-Prot;Acc:Q9U9Y8]) HSP 1 Score: 402.519 bits (1033), Expect = 5.498e-133 Identity = 205/425 (48.24%), Postives = 291/425 (68.47%), Query Frame = 3
Query: 489 AVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWS--NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMS--EAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
A++ A Y P + +++ + RP+GYGAFGVVWSV DPR+ K+ ALK++PN+F N + KR++RE+ +LS +H+N++SL+DI++ + E+Y+L + MQ+DLHKIIVSPQAL+ DHVK+F+YQILRG+KYLH+A+I+HRDIKPGN+LVNSNC+LKICDFGLAR D+R+ +T EVVTQYYRAPELLM + Y AVD+WS+GC FAELL R+ILFQA GP+EQL +I++++GTP + +A A+ +VL + P+ + K + ++ EA+ LL +L F+PD RIS EEAL H YL++ RLR+HSCMCSCC+ +KPN R F D +P P + +++S E +E + +F+ + + Y + L +NP S Y+ +SSVAQA E P+ W
Sbjct: 44 AILAAAQPFYPPPVQDSQPD------RPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCY-----TKPNMP-SRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMD--RPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 454
BLAST of NLK-1 vs. Ensembl Celegans
Match: lit-1 (Serine/threonine kinase NLK [Source:UniProtKB/Swiss-Prot;Acc:Q9U9Y8]) HSP 1 Score: 402.519 bits (1033), Expect = 5.764e-133 Identity = 205/425 (48.24%), Postives = 291/425 (68.47%), Query Frame = 3
Query: 489 AVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWS--NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMS--EAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
A++ A Y P + +++ + RP+GYGAFGVVWSV DPR+ K+ ALK++PN+F N + KR++RE+ +LS +H+N++SL+DI++ + E+Y+L + MQ+DLHKIIVSPQAL+ DHVK+F+YQILRG+KYLH+A+I+HRDIKPGN+LVNSNC+LKICDFGLAR D+R+ +T EVVTQYYRAPELLM + Y AVD+WS+GC FAELL R+ILFQA GP+EQL +I++++GTP + +A A+ +VL + P+ + K + ++ EA+ LL +L F+PD RIS EEAL H YL++ RLR+HSCMCSCC+ +KPN R F D +P P + +++S E +E + +F+ + + Y + L +NP S Y+ +SSVAQA E P+ W
Sbjct: 52 AILAAAQPFYPPPVQDSQPD------RPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCY-----TKPNMP-SRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMD--RPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 462
BLAST of NLK-1 vs. Ensembl Celegans
Match: lit-1 (Serine/threonine kinase NLK [Source:UniProtKB/Swiss-Prot;Acc:Q9U9Y8]) HSP 1 Score: 402.519 bits (1033), Expect = 5.764e-133 Identity = 205/425 (48.24%), Postives = 291/425 (68.47%), Query Frame = 3
Query: 489 AVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWS--NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMS--EAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
A++ A Y P + +++ + RP+GYGAFGVVWSV DPR+ K+ ALK++PN+F N + KR++RE+ +LS +H+N++SL+DI++ + E+Y+L + MQ+DLHKIIVSPQAL+ DHVK+F+YQILRG+KYLH+A+I+HRDIKPGN+LVNSNC+LKICDFGLAR D+R+ +T EVVTQYYRAPELLM + Y AVD+WS+GC FAELL R+ILFQA GP+EQL +I++++GTP + +A A+ +VL + P+ + K + ++ EA+ LL +L F+PD RIS EEAL H YL++ RLR+HSCMCSCC+ +KPN R F D +P P + +++S E +E + +F+ + + Y + L +NP S Y+ +SSVAQA E P+ W
Sbjct: 52 AILAAAQPFYPPPVQDSQPD------RPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCY-----TKPNMP-SRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMD--RPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 462
BLAST of NLK-1 vs. Ensembl Celegans
Match: lit-1 (Serine/threonine kinase NLK [Source:UniProtKB/Swiss-Prot;Acc:Q9U9Y8]) HSP 1 Score: 403.675 bits (1036), Expect = 1.805e-131 Identity = 205/425 (48.24%), Postives = 291/425 (68.47%), Query Frame = 3
Query: 489 AVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWS--NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMS--EAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
A++ A Y P + +++ + RP+GYGAFGVVWSV DPR+ K+ ALK++PN+F N + KR++RE+ +LS +H+N++SL+DI++ + E+Y+L + MQ+DLHKIIVSPQAL+ DHVK+F+YQILRG+KYLH+A+I+HRDIKPGN+LVNSNC+LKICDFGLAR D+R+ +T EVVTQYYRAPELLM + Y AVD+WS+GC FAELL R+ILFQA GP+EQL +I++++GTP + +A A+ +VL + P+ + K + ++ EA+ LL +L F+PD RIS EEAL H YL++ RLR+HSCMCSCC+ +KPN R F D +P P + +++S E +E + +F+ + + Y + L +NP S Y+ +SSVAQA E P+ W
Sbjct: 191 AILAAAQPFYPPPVQDSQPD------RPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCY-----TKPNMP-SRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMD--RPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 601
BLAST of NLK-1 vs. Ensembl Fly
Match: nmo (gene:FBgn0011817 transcript:FBtr0076756) HSP 1 Score: 424.091 bits (1089), Expect = 1.380e-141 Identity = 200/396 (50.51%), Postives = 275/396 (69.44%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
+RP+GYGAFGVVW+V DPR ++ ALK++PN+F + V++KR++REL +L KHEN++S +DI++ H EIY++ + +Q+DLHKIIVSPQ LS DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM + +Y+ AVD+WS+GC F ELL RRILFQA+ P++QL+LI ++GTP + D+ HA AR ++L + K P+ ++ S++ T EA+ LL ML F+PD RIS +AL+H YLD+ RLRYHSCMC CC +R + D EP +P + T + + KE + KFI Q R+ L +NP S ++ +S+VA E P+ H+W
Sbjct: 43 DRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFT-------TSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG--RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQW 429
BLAST of NLK-1 vs. Ensembl Fly
Match: nmo (gene:FBgn0011817 transcript:FBtr0333223) HSP 1 Score: 424.091 bits (1089), Expect = 1.380e-141 Identity = 200/396 (50.51%), Postives = 275/396 (69.44%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
+RP+GYGAFGVVW+V DPR ++ ALK++PN+F + V++KR++REL +L KHEN++S +DI++ H EIY++ + +Q+DLHKIIVSPQ LS DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM + +Y+ AVD+WS+GC F ELL RRILFQA+ P++QL+LI ++GTP + D+ HA AR ++L + K P+ ++ S++ T EA+ LL ML F+PD RIS +AL+H YLD+ RLRYHSCMC CC +R + D EP +P + T + + KE + KFI Q R+ L +NP S ++ +S+VA E P+ H+W
Sbjct: 43 DRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFT-------TSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG--RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQW 429
BLAST of NLK-1 vs. Ensembl Fly
Match: nmo (gene:FBgn0011817 transcript:FBtr0076759) HSP 1 Score: 424.091 bits (1089), Expect = 1.380e-141 Identity = 200/396 (50.51%), Postives = 275/396 (69.44%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
+RP+GYGAFGVVW+V DPR ++ ALK++PN+F + V++KR++REL +L KHEN++S +DI++ H EIY++ + +Q+DLHKIIVSPQ LS DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM + +Y+ AVD+WS+GC F ELL RRILFQA+ P++QL+LI ++GTP + D+ HA AR ++L + K P+ ++ S++ T EA+ LL ML F+PD RIS +AL+H YLD+ RLRYHSCMC CC +R + D EP +P + T + + KE + KFI Q R+ L +NP S ++ +S+VA E P+ H+W
Sbjct: 43 DRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFT-------TSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG--RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQW 429
BLAST of NLK-1 vs. Ensembl Fly
Match: nmo (gene:FBgn0011817 transcript:FBtr0076758) HSP 1 Score: 424.091 bits (1089), Expect = 1.380e-141 Identity = 200/396 (50.51%), Postives = 275/396 (69.44%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
+RP+GYGAFGVVW+V DPR ++ ALK++PN+F + V++KR++REL +L KHEN++S +DI++ H EIY++ + +Q+DLHKIIVSPQ LS DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM + +Y+ AVD+WS+GC F ELL RRILFQA+ P++QL+LI ++GTP + D+ HA AR ++L + K P+ ++ S++ T EA+ LL ML F+PD RIS +AL+H YLD+ RLRYHSCMC CC +R + D EP +P + T + + KE + KFI Q R+ L +NP S ++ +S+VA E P+ H+W
Sbjct: 43 DRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFT-------TSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG--RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQW 429
BLAST of NLK-1 vs. Ensembl Fly
Match: nmo (gene:FBgn0011817 transcript:FBtr0474156) HSP 1 Score: 424.091 bits (1089), Expect = 1.428e-141 Identity = 200/396 (50.51%), Postives = 275/396 (69.44%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKE-DPTNHKW 1748
+RP+GYGAFGVVW+V DPR ++ ALK++PN+F + V++KR++REL +L KHEN++S +DI++ H EIY++ + +Q+DLHKIIVSPQ LS DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM + +Y+ AVD+WS+GC F ELL RRILFQA+ P++QL+LI ++GTP + D+ HA AR ++L + K P+ ++ S++ T EA+ LL ML F+PD RIS +AL+H YLD+ RLRYHSCMC CC +R + D EP +P + T + + KE + KFI Q R+ L +NP S ++ +S+VA E P+ H+W
Sbjct: 43 DRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFT-------TSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG--RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQW 429
BLAST of NLK-1 vs. Ensembl Zebrafish
Match: nlk2 (nemo-like kinase, type 2 [Source:ZFIN;Acc:ZDB-GENE-080320-1]) HSP 1 Score: 417.927 bits (1073), Expect = 1.003e-138 Identity = 202/390 (51.79%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A AR ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC+ R + D EP+ + + T + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 66 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGARAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCYTTSSG--------RVYTSDFEPVTNPKFDDGFEKNLTSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 445
BLAST of NLK-1 vs. Ensembl Zebrafish
Match: nlk2 (nemo-like kinase, type 2 [Source:ZFIN;Acc:ZDB-GENE-080320-1]) HSP 1 Score: 417.927 bits (1073), Expect = 1.184e-138 Identity = 202/390 (51.79%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A AR ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC+ R + D EP+ + + T + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 71 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGARAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCYTTSSG--------RVYTSDFEPVTNPKFDDGFEKNLTSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 450
BLAST of NLK-1 vs. Ensembl Zebrafish
Match: nlk2 (nemo-like kinase, type 2 [Source:ZFIN;Acc:ZDB-GENE-080320-1]) HSP 1 Score: 418.313 bits (1074), Expect = 9.700e-138 Identity = 202/390 (51.79%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A AR ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC+ R + D EP+ + + T + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 147 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGARAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCYTTSSG--------RVYTSDFEPVTNPKFDDGFEKNLTSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 526
BLAST of NLK-1 vs. Ensembl Zebrafish
Match: nlk1 (nemo-like kinase, type 1 [Source:ZFIN;Acc:ZDB-GENE-040701-1]) HSP 1 Score: 410.223 bits (1053), Expect = 2.046e-135 Identity = 198/383 (51.70%), Postives = 269/383 (70.23%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSV 1712
+RP+GYGAFGVVWSV DPR +K ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ +EIY++ + MQ+DLHK+IVSPQ L+ DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYRAPE+LM +Y ++D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTPPL+ + A AR ++L K P+L ++ S+ T EA+ LL ML F+P RIS +ALSH YLD+ RLRYH+CMC CC+ S P+ R + D EP +P S + S + + KE I +FI + Q R+ L +NP S ++ + S+
Sbjct: 91 DRPIGYGAFGVVWSVTDPRDGRKVALKKMPNVFQNLVSCKRVFRELRMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQSDLHKVIVSPQPLTTDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCLLKICDFGLARVEEPDPSRHMTQEVVTQYYRAPEVLMGCQHYTSSIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPPLSAMTSACEGARAHILRGPHKPPSLSVLYMLSDGATHEAVHLLCRMLVFDPAKRISGSDALSHPYLDEGRLRYHTCMCKCCY-----SVPSG---RVYTRDFEPPADRPFSHNYEQSMHSVWQGKELIHRFITEHQQGK--RVPLCINPQSAAFKTFIRSTA 463
BLAST of NLK-1 vs. Ensembl Zebrafish
Match: nlk1 (nemo-like kinase, type 1 [Source:ZFIN;Acc:ZDB-GENE-040701-1]) HSP 1 Score: 298.13 bits (762), Expect = 2.196e-94 Identity = 139/241 (57.68%), Postives = 185/241 (76.76%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRK 1286
+RP+GYGAFGVVWSV DPR +K ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ +EIY++ + MQ+DLHK+IVSPQ L+ DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYRAPE+LM +Y ++D+WS+GC FAELL RRILFQA+ P++Q+ + + G L L D +Y ++S RK
Sbjct: 91 DRPIGYGAFGVVWSVTDPRDGRKVALKKMPNVFQNLVSCKRVFRELRMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQSDLHKVIVSPQPLTTDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCLLKICDFGLARVEEPDPSRHMTQEVVTQYYRAPEVLMGCQHYTSSIDVWSVGCIFAELLGRRILFQAQSPIQQVMMDTSFKGLKILAFL----QDVKYVLVSSRK 327
BLAST of NLK-1 vs. Ensembl Xenopus
Match: nlk (nemo-like kinase [Source:NCBI gene;Acc:100144638]) HSP 1 Score: 416.001 bits (1068), Expect = 9.449e-138 Identity = 202/390 (51.79%), Postives = 274/390 (70.26%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EPI T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 72 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSG--------RVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 451
BLAST of NLK-1 vs. Ensembl Xenopus
Match: nlk (nemo-like kinase [Source:NCBI gene;Acc:100144638]) HSP 1 Score: 416.772 bits (1070), Expect = 5.764e-137 Identity = 202/390 (51.79%), Postives = 274/390 (70.26%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EPI T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 148 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSG--------RVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 527
BLAST of NLK-1 vs. Ensembl Xenopus
Match: nlk (nemo-like kinase [Source:NCBI gene;Acc:100144638]) HSP 1 Score: 404.06 bits (1037), Expect = 2.077e-133 Identity = 196/379 (51.72%), Postives = 266/379 (70.18%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLL 1700
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EPI T + + + + + KE I +FI Q+ R+ L +NP S ++ +
Sbjct: 62 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSG--------RVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFI 430
BLAST of NLK-1 vs. Ensembl Xenopus
Match: nlk (nemo-like kinase [Source:NCBI gene;Acc:100144638]) HSP 1 Score: 378.637 bits (971), Expect = 1.433e-124 Identity = 187/370 (50.54%), Postives = 257/370 (69.46%), Query Frame = 3
Query: 603 SVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSV 1712
SV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EPI T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+V
Sbjct: 10 SVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSG--------RVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTV 369
BLAST of NLK-1 vs. Ensembl Xenopus
Match: nlk (nemo-like kinase [Source:NCBI gene;Acc:100144638]) HSP 1 Score: 374.4 bits (960), Expect = 6.951e-123 Identity = 185/366 (50.55%), Postives = 253/366 (69.13%), Query Frame = 3
Query: 603 SVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLL 1700
SV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EPI T + + + + + KE I +FI Q+ R+ L +NP S ++ +
Sbjct: 9 SVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSG--------RVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFI 364
BLAST of NLK-1 vs. Ensembl Mouse
Match: Nlk (nemo like kinase [Source:MGI Symbol;Acc:MGI:1201387]) HSP 1 Score: 416.772 bits (1070), Expect = 3.420e-137 Identity = 201/390 (51.54%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. Ensembl Mouse
Match: Mapk7 (mitogen-activated protein kinase 7 [Source:MGI Symbol;Acc:MGI:1346347]) HSP 1 Score: 247.284 bits (630), Expect = 3.690e-70 Identity = 149/400 (37.25%), Postives = 212/400 (53.00%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISP------LTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTP-PLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSN---NVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYY-QKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPT 1736
+G GA+GVV S T ++ A+K+IPN F AKR REL IL H KH+NII++ DI+K + +Y++ D M++DLH+II S Q L+++HV+ FLYQ+LRG+KY+HSA +IHRD+KP N+LVN NC LKI DFG+AR SP +T+ V T++YRAPEL++ Y A+D+WS+GC F E+L RR LF K + QL LI+ ++GTP P R Y+ S ++P W +AL LL ML+F P RIS+ AL H +L +YH D EP C P D KE I I++++ +++ R ++ P + QP+ + V E P+
Sbjct: 61 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR---GLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP-----VPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL----AKYHDP------------------------DDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQP---SLQPVASEPVCPDVEMPS 421
BLAST of NLK-1 vs. Ensembl Mouse
Match: Mapk3 (mitogen-activated protein kinase 3 [Source:MGI Symbol;Acc:MGI:1346859]) HSP 1 Score: 236.113 bits (601), Expect = 4.422e-70 Identity = 130/288 (45.14%), Postives = 187/288 (64.93%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKR--NISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL +HEN+I + DI+++ ++YI+ D M+TDL+K++ S Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLARI D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+ S K AK +AL LLD ML FNP+ RI+ EEAL+H YL+
Sbjct: 49 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY-CQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV--AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 332
BLAST of NLK-1 vs. Ensembl Mouse
Match: Mapk3 (mitogen-activated protein kinase 3 [Source:MGI Symbol;Acc:MGI:1346859]) HSP 1 Score: 235.343 bits (599), Expect = 7.492e-70 Identity = 130/288 (45.14%), Postives = 187/288 (64.93%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKR--NISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL +HEN+I + DI+++ ++YI+ D M+TDL+K++ S Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLARI D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+ S K AK +AL LLD ML FNP+ RI+ EEAL+H YL+
Sbjct: 49 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY-CQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV--AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 332
BLAST of NLK-1 vs. Ensembl Mouse
Match: Mapk1 (mitogen-activated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1346858]) HSP 1 Score: 233.032 bits (593), Expect = 2.642e-69 Identity = 129/291 (44.33%), Postives = 187/291 (64.26%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDK--RNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSN---NVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL +HENII + DI+++ ++YI+ D M+TDL+K++ + Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLAR+ D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+LS K W+ N +AL LLD ML FNP RI E+AL+H YL+
Sbjct: 29 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTY-CQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNK-----VPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 312
BLAST of NLK-1 vs. UniProt/SwissProt
Match: sp|E2QWQ2|NLK_CANLF (Serine/threonine-protein kinase NLK OS=Canis lupus familiaris OX=9615 GN=NLK PE=3 SV=1) HSP 1 Score: 417.157 bits (1071), Expect = 1.297e-136 Identity = 202/390 (51.79%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EPI T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. UniProt/SwissProt
Match: sp|Q9UBE8|NLK_HUMAN (Serine/threonine-protein kinase NLK OS=Homo sapiens OX=9606 GN=NLK PE=1 SV=2) HSP 1 Score: 416.772 bits (1070), Expect = 2.341e-136 Identity = 201/390 (51.54%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. UniProt/SwissProt
Match: sp|D3ZSZ3|NLK_RAT (Serine/threonine-protein kinase NLK OS=Rattus norvegicus OX=10116 GN=Nlk PE=3 SV=1) HSP 1 Score: 416.772 bits (1070), Expect = 2.392e-136 Identity = 201/390 (51.54%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. UniProt/SwissProt
Match: sp|O54949|NLK_MOUSE (Serine/threonine-protein kinase NLK OS=Mus musculus OX=10090 GN=Nlk PE=1 SV=2) HSP 1 Score: 416.772 bits (1070), Expect = 2.392e-136 Identity = 201/390 (51.54%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. UniProt/SwissProt
Match: sp|E1BMN8|NLK_BOVIN (Serine/threonine-protein kinase NLK OS=Bos taurus OX=9913 GN=NLK PE=3 SV=2) HSP 1 Score: 416.387 bits (1069), Expect = 3.665e-136 Identity = 201/390 (51.54%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP L + A A+ ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC R + D EP+ T + + + + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 148 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTG--------RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 527
BLAST of NLK-1 vs. TrEMBL
Match: H9CXV4 (Mitogen-activated protein kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 944.495 bits (2440), Expect = 0.000e+0 Identity = 465/465 (100.00%), Postives = 465/465 (100.00%), Query Frame = 3
Query: 354 MLVGQRIHAGVTSLTXXXXXXXXXXXQTELDSKLMRDDKQEEALLAVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 1748
MLVGQRIHAGVTSLTSSKSNNFKSKSQTELDSKLMRDDKQEEALLAVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW
Sbjct: 1 MLVGQRIHAGVTSLTSSKSNNFKSKSQTELDSKLMRDDKQEEALLAVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 465
BLAST of NLK-1 vs. TrEMBL
Match: A0A0X3PZK9 (Mitogen-activated protein kinase OS=Schistocephalus solidus OX=70667 GN=NLK PE=3 SV=1) HSP 1 Score: 497.664 bits (1280), Expect = 2.700e-165 Identity = 253/488 (51.84%), Postives = 333/488 (68.24%), Query Frame = 3
Query: 447 SKLMRDDKQEEALLAVI---DEANGC--YAPILLNNKC---EDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHD---------------HQDS------------------------------SKPNDGIV-RNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 1748
S + ++EALLA+ EA G Y P LL + ++ E+ LGYGAFGVVWSV DPR +K ALKRIP +FHN +TAKR+YREL +LS ++H+N++SL+D+VK+D DE+Y+L + MQTDLHKIIVSPQ LS DHVKIFLYQILRG++YLHSA I+HRDIKPGNMLVNSNCLLKICDFGLAR++D +N + LTQEVVTQYYR+PELLME+S Y++AVD+WS+GCTFAELL RRILF A PLEQ++LILN+ GTP + DL H HP+A +VLS R ++PNL + S ++ A+ LL SML+FNP RI++EEALSH YL++ARLRYHSCMC+CCHD + DS S + G+ R FC + +P + +D+ F ++S+AK + + ++ Y+++D RL+LN N+ NY+ L+TS+VAQAKE P +H+W
Sbjct: 50 SSFAQTQSRDEALLAIYVHPAEAGGVGHYKPFLLPPRAPGESSHSSLEKGLGYGAFGVVWSVIDPRDGRKVALKRIPRVFHNPITAKRVYRELKMLSLLRHDNVVSLIDVVKTDSYSSFDEVYLLFELMQTDLHKIIVSPQPLSSDHVKIFLYQILRGLRYLHSAGIVHRDIKPGNMLVNSNCLLKICDFGLARMDDPKNQAQLTQEVVTQYYRSPELLMEASRYSYAVDIWSVGCTFAELLSRRILFPAHSPLEQIELILNLTGTPSMDDLQHCHPEACCFVLSFRPRRPNLATLYSLSPDMNASAVDLLSSMLRFNPKERITAEEALSHPYLEEARLRYHSCMCTCCHDVPVSTSQTSLGSPGVNGDSGSLSSAPTTPTSSISSASSGSEAHGKLSIGSNSSSGLTRRKFCQNLDPTANFLLPLDLDSHFKRLSDAKRILWETVQEYFRRDTRTARLILNKNAANYKALVTSNVAQAKEMPASHRW 537
BLAST of NLK-1 vs. TrEMBL
Match: A0A5K3EJC8 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 496.123 bits (1276), Expect = 4.005e-164 Identity = 257/484 (53.10%), Postives = 328/484 (67.77%), Query Frame = 3
Query: 468 KQEEALLAVI---DEANGC--YAPILL---NNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKP-------NDGIV------------------------------------------RNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 1748
+++EALLA+ EA G Y P LL N + E+ LGYGAFGVVWSV DPR +K ALKRIP +FHN +TAKR+YREL +LS + H+NI++LVD+VKSD+ DE+Y+L + MQTDLHKIIVSPQ LS DHVKIFLYQILRG++YLHSA I+HRDIKPGNMLVNSNCLLKICDFGLAR++D N + LT EVVTQYYR+PELLME+S Y++AVDMWS+GCTFAELL RRILF A+GPLEQL+LILN+ GTP + DL H HP+A +VLS R ++PNL + S +++ A+ LL SML+F+P RI++EEALSH YL++ARLRYHSCMC+CCHD +S P + G V R FC D +P + +D+ F ++S+AK + + ++ Y+ +D RL+LN N+ NY+ L+TSSVAQAKE P +W
Sbjct: 88 QRDEALLAIYVHPSEAGGVGHYKPFLLPPRNPGEGSQSSLEKGLGYGAFGVVWSVIDPRDGRKVALKRIPRVFHNPITAKRVYRELKMLSMLHHDNIVTLVDVVKSDNYSSFDEVYLLFELMQTDLHKIIVSPQPLSSDHVKIFLYQILRGLRYLHSAGIVHRDIKPGNMLVNSNCLLKICDFGLARMDDPGNQAQLTTEVVTQYYRSPELLMETSRYSYAVDMWSVGCTFAELLSRRILFPAQGPLEQLELILNLTGTPKMVDLEHCHPEACCFVLSFRPRRPNLASLYSLSPDLSNAAVDLLSSMLRFSPKDRITAEEALSHCYLEEARLRYHSCMCTCCHDVPVASPPATQGGLSSPGAVGDNASLSSAPTTPTSSISSSSSSISPSDTPGKQQQHPGNLTRRKFCRDLDPAANFLLPLDLDSHFKRLSDAKRILWETLQEYHHRDTRSARLILNKNAVNYRALVTSSVAQAKEMPPARRW 571
BLAST of NLK-1 vs. TrEMBL
Match: A0A564YF87 (Mitogen-activated protein kinase OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS5308 PE=3 SV=1) HSP 1 Score: 486.878 bits (1252), Expect = 9.073e-161 Identity = 248/483 (51.35%), Postives = 323/483 (66.87%), Query Frame = 3
Query: 471 QEEALLAVIDEAN-----GCYAPILL---NNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHD-----------------------------------------------HQDSSKPNDGIV--RNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 1748
+EEALLA+ + G Y P LL N E+ LGYGAFGVVWSV DPR +K ALKRIP +FHN +TAKR+YRE+ +LS + H+NI++LVD+VKSD+ DE+Y++ + MQTDLHKIIVSPQ LS DHVKIFLYQILRG++YLHSA I+HRDIKPGNMLVNSNCLLKICDFGLAR++D +N + LT EVVTQYYR+PELLME+S Y++AVDMWS+GCTFAELL RRILF A+GPLEQL+LI+N+ GTP + DL + HP+A +VLS R ++PNL S +V+ A+ L+ +ML FNP RI++EEAL+HSYL++ARLRYHSCMC+CCHD +P G++ R FC D +P + +D+ F ++S+AK + ++ Y+ +D +L+LN N+ NY+ L+TS+VAQAKE P +W
Sbjct: 72 REEALLAIYVQPTEIGGVGHYKPFLLPPRNPGDSSQNALEKGLGYGAFGVVWSVIDPRDGRKVALKRIPRVFHNPITAKRVYREVKMLSMLHHDNIVTLVDVVKSDNYSNFDEVYLIFELMQTDLHKIIVSPQPLSTDHVKIFLYQILRGLRYLHSAGIVHRDIKPGNMLVNSNCLLKICDFGLARMDDPKNQAQLTTEVVTQYYRSPELLMETSRYSYAVDMWSVGCTFAELLSRRILFPAQGPLEQLELIVNLTGTPNVEDLENCHPEACCFVLSFRPRRPNLAFFYSLSPDVSSAAVDLISNMLCFNPKARITAEEALNHSYLEEARLRYHSCMCTCCHDVPVTQSGGLSSPGGVSDNGSLSSAPATPTSSISSTSTASSPADTPGKGIQQQRPGTGVLTRRKFCRDLDPAANFLLPLDLDSHFKRLSDAKRILWDTLQEYHHRDPRSAKLILNKNAANYRALVTSNVAQAKEMPAARRW 554
BLAST of NLK-1 vs. TrEMBL
Match: A0A068YGR6 (Mitogen-activated protein kinase OS=Echinococcus multilocularis OX=6211 GN=EmuJ_001020300 PE=3 SV=1) HSP 1 Score: 487.263 bits (1253), Expect = 2.203e-160 Identity = 248/484 (51.24%), Postives = 329/484 (67.98%), Query Frame = 3
Query: 471 QEEALLAVI---DEANGC--YAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHD---------------------------------------------------HQDSSKPNDGIV-RNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP-TNHKW 1748
+EEALLA+ +A G Y P LL + + E+ LGYGAFGVVWSV DPR ++ ALKRIP +FHN +TAKR+YREL +LS + H+NI+SL+D+VKSD+ DE+Y+L + MQTDLHKIIVSPQ LS DHVKIFLYQILRG++YLHSA I+HRDIKPGNMLVNSNCLLKICDFGLAR++D +N + LT EVVTQYYR+PELLME+S Y++AVD+WS+GCTFAELL RRILF A+GPLEQL+LI+N+ GTP + DL + HP+A +VLS R ++PNL + S ++T A+ L+ SML+FNP RI++EEAL+H YL++ARLRYHSCMC+CCHD Q +P + R FC + +PI + +D+ F ++S+AK + ++ Y+ +D +L+LN N+ NY+ L+TS+VAQAKE P ++H++
Sbjct: 62 REEALLAIYVHPTDAGGVGHYKPFLLPPRAPGESSLEKGLGYGAFGVVWSVIDPRDGRRVALKRIPRVFHNPITAKRVYRELKMLSVLHHDNIVSLIDVVKSDNYSNFDEVYLLFELMQTDLHKIIVSPQPLSSDHVKIFLYQILRGLRYLHSAGIVHRDIKPGNMLVNSNCLLKICDFGLARMDDPKNQAQLTTEVVTQYYRSPELLMETSRYSYAVDIWSVGCTFAELLSRRILFPAQGPLEQLELIVNLTGTPTIEDLENCHPEACCFVLSFRPRRPNLAFLYSLSPDITGAAVELISSMLRFNPKARITAEEALNHCYLEEARLRYHSCMCTCCHDVPVTPTSTQGTMSSPGGVSDNGSLSSAPVTPTSSISSAASSASTSPADTPGKQQQQRPAGVLTRRKFCRNLDPIANFLLPLDLDSHFKRLSDAKRILWDTLQEYHHRDTRSAKLILNKNAANYRALVTSNVAQAKEIPASSHQY 545
BLAST of NLK-1 vs. Ensembl Cavefish
Match: nlk1 (serine/threonine-protein kinase NLK2-like [Source:NCBI gene;Acc:103027970]) HSP 1 Score: 416.387 bits (1069), Expect = 6.339e-138 Identity = 200/383 (52.22%), Postives = 271/383 (70.76%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSV 1712
+RP+GYGAFGVVWSV DPR +K ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ +EIY++ + MQ+DLHK+IVSPQ L+ DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTPPL+ + A AR ++L K P+L ++ S+ T EA+ LL ML F+P RIS +ALSH YLD+ RLRYH+CMC CC+ S P+ R + D EP +P S + + S + + KE I +FI + Q R+ L +NP S ++ + S+
Sbjct: 94 DRPIGYGAFGVVWSVTDPRDGRKVALKKMPNVFQNLVSCKRVFRELRMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQSDLHKVIVSPQPLTTDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCLLKICDFGLARVEEPDPTRHMTQEVVTQYYRAPEVLMGSRHYGPAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPPLSAMASACEGARAHILRGPHKPPSLSVLYMLSDAATHEAVHLLCRMLVFDPAKRISGSDALSHPYLDEGRLRYHTCMCQCCY-----SVPSG---RVYTRDFEPPAERPFSHSYEESMLSVWQGKELIHRFITEHQQGK--RVPLCINPQSAAFKTFIRSTA 466
BLAST of NLK-1 vs. Ensembl Cavefish
Match: nlk2 (nemo-like kinase, type 2 [Source:ZFIN;Acc:ZDB-GENE-080320-1]) HSP 1 Score: 387.497 bits (994), Expect = 3.394e-126 Identity = 194/390 (49.74%), Postives = 262/390 (67.18%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ H +EIY++ + MQ+DLHKIIVSPQ LS DHVK+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y LL RRILFQA+ P++QLDLI +++GTP L + A AR ++L K+P+L ++ SN T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC+ R + D EP+ + + T + + KE I +FI Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 142 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDESRHMTQEVVTQYYRAPEILMGSRHY-------------TNLLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGARAHILRGPHKQPSLPVLYTLSNQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCYTTSSG--------RVYTSDFEPVTNPKFDDGFEKNLTSVRQVKEIIHQFILE--QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMP 508
BLAST of NLK-1 vs. Ensembl Cavefish
Match: mapk3 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:103041389]) HSP 1 Score: 236.884 bits (603), Expect = 1.963e-70 Identity = 132/290 (45.52%), Postives = 190/290 (65.52%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKR--NISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYV--LSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S FD + + A+K+I H T +R RE+ IL +HENII + DI+++ ++YI+ D M+TDL+K++ + Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLARI D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+ L ++ K P + K N +AL LLD ML FNP RI+ EEAL+H YL+
Sbjct: 62 IGEGAYGMVCSAFDNVNKIRVAIKKISPFEHQTY-CQRTLREIKILLRFRHENIIGINDILRARRIDYMRDVYIVQDLMETDLYKLLKT-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFPKADN----KALDLLDRMLTFNPIKRITVEEALAHPYLE 345
BLAST of NLK-1 vs. Ensembl Cavefish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:103047585]) HSP 1 Score: 235.728 bits (600), Expect = 2.769e-70 Identity = 134/293 (45.73%), Postives = 190/293 (64.85%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDK--RNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLS--KRKKKPNLGMIAKWSN---NVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL KHENIIS+ DI+++ ++YI+ D M+TDL+K++ + Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLAR+ D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+LS R K P W+ N +AL LLD ML FNP RI EEAL+H YL+
Sbjct: 42 IGEGAYGMVCSAYDRDNKVRVAIKKISPFEHQTY-CQRTLREIKILLRFKHENIISINDIIRAPSIDQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRCKVP-------WNRLFPNADPKALDLLDKMLTFNPHKRIEVEEALAHPYLE 325
BLAST of NLK-1 vs. Ensembl Cavefish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:103047585]) HSP 1 Score: 235.343 bits (599), Expect = 1.165e-69 Identity = 134/293 (45.73%), Postives = 190/293 (64.85%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDK--RNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLS--KRKKKPNLGMIAKWSN---NVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V S +D + + A+K+I H T +R RE+ IL KHENIIS+ DI+++ ++YI+ D M+TDL+K++ + Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLAR+ D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R +F K L+QL+ IL I+G+P DL C + AR Y+LS R K P W+ N +AL LLD ML FNP RI EEAL+H YL+
Sbjct: 42 IGEGAYGMVCSAYDRDNKVRVAIKKISPFEHQTY-CQRTLREIKILLRFKHENIISINDIIRAPSIDQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRCKVP-------WNRLFPNADPKALDLLDKMLTFNPHKRIEVEEALAHPYLE 325
BLAST of NLK-1 vs. Ensembl Sea Lamprey
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2]) HSP 1 Score: 231.876 bits (590), Expect = 1.562e-69 Identity = 131/290 (45.17%), Postives = 186/290 (64.14%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDK--RNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYV--LSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V + FD + A+K+I H T +R RE+ IL KHENII + DI+++ ++YI+ D M+TDL+K++ Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLAR+ D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L R LF K L+QL+ IL I+G+P DL C + AR Y+ L + K P + K +AL LLD ML FNP RI+ EEAL+H YL+
Sbjct: 42 IGEGAYGMVCAAFDNVKLVRVAIKKISPFEHQTY-CQRTLREIKILLRFKHENIIGINDILRASTIDQMKDVYIVQDLMETDLYKLLKG-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPLFPGKHYLDQLNHILGILGSPSQEDLDCIINMKARNYLQSLPPKAKVPWNRLFPK----ADSKALDLLDKMLTFNPHRRITVEEALAHPYLE 325
BLAST of NLK-1 vs. Ensembl Sea Lamprey
Match: mapk12a (mitogen-activated protein kinase 12a [Source:NCBI gene;Acc:30681]) HSP 1 Score: 219.935 bits (559), Expect = 4.526e-65 Identity = 122/307 (39.74%), Postives = 182/307 (59.28%), Query Frame = 3
Query: 549 DNTLWERP--------LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPP--LTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDAR 1436
+ +WE P +G GA+G V S D T K A+K++ F + V AKR YREL +L H+KHEN+I LVD+ + + + Y++ FM TDL KI+ + S D V+ +YQIL+G+KY+HS+ IIHRD+KPGN+ VN +C LKI DFGLAR D+ +T VVT++YRAPE+++ +Y VD+WS+GC AE++ + LF ++QL LIL + GTPP L D + A+Y + +K + + +N + A+ LL+ ML +P+ R ++ EAL H + + R
Sbjct: 17 NKMVWEVPKRYSQLFAVGSGAYGTVCSSMDLVTGSKVAVKKLYRPFQSRVFAKRAYRELRLLKHMKHENVIGLVDVFTPNDTLDQFQDFYLVMPFMGTDLSKIMKHGKQ-SDDKVQYLIYQILKGLKYIHSSGIIHRDLKPGNLAVNEDCELKILDFGLARHADQE----MTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKPLFPGNDHMDQLMLILKLTGTPPQYLVDRMDENEAAKYIKTLPKMEKRRISTVFPNANPI---AIDLLEKMLALDPEQRPTASEALQHPFFSETR 315
BLAST of NLK-1 vs. Ensembl Sea Lamprey
Match: mapk14a (mitogen-activated protein kinase 14a [Source:NCBI gene;Acc:65237]) HSP 1 Score: 216.468 bits (550), Expect = 6.791e-64 Identity = 128/308 (41.56%), Postives = 181/308 (58.77%), Query Frame = 3
Query: 549 DNTLWERP--------LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAK----GPLEQLDLILNIVGTPP--LTDLCHAHPDARYYVLS-KRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
+ T+WE P +G GA+G V S D +T K A+K++ F + + AKR YREL +L H+KHEN+I L+D+ + S D++Y++ D M DL+ I V Q L+ DHV+ +YQILRG+KY+HSA IIHRD+KP N+ VN +C LKI DFGLAR D +T V T++YRAPE+++ +Y VD+WS+GC AELL R LF + QL IL + GTPP L D + +AR Y+ S +K + + +N + + LL+ ML + D RI++ EAL H Y
Sbjct: 15 NKTVWEVPRRYVNLTSVGSGAYGSVCSSLDTKTGMKVAVKKLSRPFQSVIHAKRTYRELRLLKHMKHENVIGLMDVFTPNSSLEEFDDLYLVTDLMGADLNNI-VKCQKLTDDHVQFLVYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHADDE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDRILSDINQLVKILQLTGTPPQYLIDRMQSK-EARNYIQSLPYTQKRDFKDVFLGANPL---VVDLLERMLVLDTDQRITAAEALVHQYF 313
BLAST of NLK-1 vs. Ensembl Sea Lamprey
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307]) HSP 1 Score: 202.216 bits (513), Expect = 4.814e-57 Identity = 107/290 (36.90%), Postives = 164/290 (56.55%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAK-RLYRELFILSHIK-HENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLAR----IEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
LG G G+VW D + A+K+I + F N A+ R +RE+ L H NII+L +++++D+ + +IY++ DFM TDLH +I L H YQ+L+ KY+HS ++IHRD KP N+L++ C +K+CDFGLAR I D+ LT+ V T++YRAPE+L+ S Y VDMWS+GC E+L + +F L Q++ I++++ P D+ + VL K ++ + N AL LL +L FNP+ R+++EEAL H Y+
Sbjct: 19 LGKGELGIVWKGVDRKNGDVVAIKKIFDAFRNQTDAQQRTFREIIFLQEFGDHPNIINLRNVLRADN---DKDIYLVFDFMDTDLHAVIRKGNILKDVHKAYITYQLLKATKYIHSGNVIHRDQKPSNVLLDGECFVKLCDFGLARSLKQIRDEPGDPALTEYVATRWYRAPEILLASPRYTKGVDMWSVGCIVGEMLLGKAIFPGTSTLNQIERIMSVIPQPSKEDVLAIKSEYGGSVLEKMGRQRQ--SLESLLPNAPPNALDLLKRLLVFNPEKRLTAEEALGHPYV 303
BLAST of NLK-1 vs. Ensembl Sea Lamprey
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307]) HSP 1 Score: 201.445 bits (511), Expect = 2.294e-56 Identity = 107/290 (36.90%), Postives = 164/290 (56.55%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAK-RLYRELFILSHIK-HENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLAR----IEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
LG G G+VW D + A+K+I + F N A+ R +RE+ L H NII+L +++++D+ + +IY++ DFM TDLH +I L H YQ+L+ KY+HS ++IHRD KP N+L++ C +K+CDFGLAR I D+ LT+ V T++YRAPE+L+ S Y VDMWS+GC E+L + +F L Q++ I++++ P D+ + VL K ++ + N AL LL +L FNP+ R+++EEAL H Y+
Sbjct: 20 LGKGELGIVWKGVDRKNGDVVAIKKIFDAFRNQTDAQQRTFREIIFLQEFGDHPNIINLRNVLRADN---DKDIYLVFDFMDTDLHAVIRKGNILKDVHKAYITYQLLKATKYIHSGNVIHRDQKPSNVLLDGECFVKLCDFGLARSLKQIRDEPGDPALTEYVATRWYRAPEILLASPRYTKGVDMWSVGCIVGEMLLGKAIFPGTSTLNQIERIMSVIPQPSKEDVLAIKSEYGGSVLEKMGRQRQ--SLESLLPNAPPNALDLLKRLLVFNPEKRLTAEEALGHPYV 304
BLAST of NLK-1 vs. Ensembl Yeast
Match: FUS3 (Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis [Source:SGD;Acc:S000000112]) HSP 1 Score: 225.328 bits (573), Expect = 1.887e-67 Identity = 134/296 (45.27%), Postives = 183/296 (61.82%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNI---------SPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTP-PLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
LG GA+GVV S T + A+K+I F + A R RE+ IL H KHENII++ +I + D SF N +E+YI+ + MQTDLH++I S Q LS DH++ F+YQ LR VK LH +++IHRD+KP N+L+NSNC LK+CDFGLARI D+ S +T+ V T++YRAPE+++ S+ Y+ A+D+WS GC AEL RR +F + QL LI I+GTP DL C P AR Y+ K + K V + + LL ML F+P RI+++EAL H YL
Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYI--KSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309
BLAST of NLK-1 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 222.246 bits (565), Expect = 2.130e-65 Identity = 121/287 (42.16%), Postives = 176/287 (61.32%), Query Frame = 3
Query: 570 PLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPP---LTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSY 1421
P+G GAFG+V S D T + A+K+I F V AKR YREL +L H++HEN+I L DI S ++IY + + TDLH+++ + + L V+ FLYQILRG+KY+HSA +IHRD+KP N+L+N NC LKICDFGLARI+D + +T V T+YYRAPE+++ Y VD+WS GC FAE++ + LF K + Q +I +++G+PP + +C + L R P ++ V +A+ LL+ ML F+P RI++ +AL+H Y
Sbjct: 28 PVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPL----EDIYFVTELQGTDLHRLLQT-RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ----MTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIP----FSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPY 301
BLAST of NLK-1 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 204.527 bits (519), Expect = 1.318e-59 Identity = 119/296 (40.20%), Postives = 173/296 (58.45%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHI-KHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQA----LSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARI----EDKRN--ISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWS-NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
+G GA+G V S + K A+K+I F + R RE+ +L + +HENIIS++D V+ + +Y++ + M+TDL K+I + + LS DHV+ F YQILR +K +HSA +IHRDIKP N+L+NSNC LK+CDFGLAR D R + +T+ V T++YRAPE+++ Y A+D+WS GC AE++ + LF + QL LIL ++GTP D ++ +P L WS ++ + + LLD ML+FNPD RIS+ EAL H YL
Sbjct: 19 IGEGAYGTVCSAIHKPSGIKVAIKKI-QPFSKKLFVTRTIREIKLLRYFHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYL 313
BLAST of NLK-1 vs. Ensembl Yeast
Match: SLT2 (Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway [Source:SGD;Acc:S000001072]) HSP 1 Score: 206.838 bits (525), Expect = 2.864e-59 Identity = 122/300 (40.67%), Postives = 177/300 (59.00%), Query Frame = 3
Query: 567 RPLGYGAFGVVWSV--FDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIK-HENIISL--VDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDK---RNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCH-AHPDARYYVLSKRKKKPNLGMIAKWS-----NNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
+ +G+GA+G+V S + A+K++ N+F T+ KR REL +L H + H+NI L +DIV IN +Y+ + M+ D+H+II S Q L+ H + F YQIL G+KY+HSA ++HRD+KPGN+LVN++C LKICDFGLAR + N LT+ V T++YRAPE+++ Y A+D+WS GC AE L + +F+ K + QL+ IL ++GTPP L + + Y+ LG I K N +AL LL+ ML F+P RI+ +EAL H YL
Sbjct: 27 KEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSING-LYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIH-------QLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHPYL 318
BLAST of NLK-1 vs. Ensembl Yeast
Match: SMK1 (Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p [Source:SGD;Acc:S000006258]) HSP 1 Score: 200.29 bits (508), Expect = 8.717e-58 Identity = 132/369 (35.77%), Postives = 204/369 (55.28%), Query Frame = 3
Query: 573 LGYGAFGVVWSV-FDPRT-RKKAALKRIPNIFHNTVTAKRLYRELFILSHIK-HENIISLVD--IVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLAR------IEDKRNISP-LTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSN---NVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPK-PISSTIDNSFTKMSEAKETIKKFIKNY 1631
LG GA+G V SV F R+ + A+K+I NIF+ + KR REL ++ K H+NI++L+D IV S D +Y + + DL K+I S LS H+K FLYQIL G+KY+HSA +IHRD+KPGN+L N LKICDFGLAR + + P +T V T++YRAPELL+ + Y+ +VD+W++GC AE R+ +F + + Q+ I+ ++GTP D+ + + L K P I WSN + EA+ L++S+L ++ HR++ E+A+SH +L++ R KP+D EP+C + P T ++ MS+ ++ + + +KN+
Sbjct: 44 LGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPY---DGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPD-KDILIKFGTIKAWNLGKNSNNPVYKKIP-WSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPFLNEVR------------------KPDD----------EPVCLQGPFDFTYESELNSMSKLRDYLVEEVKNF 379
BLAST of NLK-1 vs. Ensembl Nematostella
Match: EDO30527 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0K0]) HSP 1 Score: 391.349 bits (1004), Expect = 2.464e-129 Identity = 196/386 (50.78%), Postives = 263/386 (68.13%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPD--ARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVA 1715
+RP+GYGAFGVVWSV DPR K+ ALK++P +F N +++R YREL +L +KH+N+IS +DIV H + EIY++ + MQ+DLHKIIVSPQ L+ DHVK+FLYQILRG+KYL SA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYR+PELL S++Y AVD+WS+GC FAELL R+ILFQA+ P++QL+ I++++GTP L DL A A Y+L + K P L + SN T EA+ LL ML FNP+ RIS +ALSH YLD+ RLR+H+CMC CC + P R + D EP+ P + + + +S KE++ K++ + + L +N S +++ S VA
Sbjct: 42 DRPIGYGAFGVVWSVTDPRNGKRVALKKMPKVFQNITSSRRAYRELRMLCTLKHDNVISAIDIVHPGHIDLFHEIYVVSELMQSDLHKIIVSPQPLTADHVKVFLYQILRGLKYLDSAKILHRDIKPGNLLVNSNCLLKICDFGLARLEEPDESVIMTQEVVTQYYRSPELLTGSTHYTQAVDIWSVGCIFAELLSRKILFQAQSPVQQLNQIIDLLGTPCLEDLSKAGSSEGATKYILQRPHKPPALASLYNLSNQATHEAVHLLCRMLVFNPNKRISCIDALSHPYLDEGRLRFHTCMCKCCQ-----TTPAG---RQYVSDFEPVNPARFDDSYEYNLNDISSIKESLYKYVLEHQGNS---VPLCINMASPSFKSFQRSGVA 416
BLAST of NLK-1 vs. Ensembl Nematostella
Match: EDO37435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFQ0]) HSP 1 Score: 245.358 bits (625), Expect = 1.558e-74 Identity = 133/288 (46.18%), Postives = 195/288 (67.71%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDK--RNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTD-LCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLD 1427
+G GA+G+V + D T ++ A+K+I H T +R RE+ ILS KHENII ++DI+++ + +IYI+ M+TD++K++ + Q LS DH+ FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLARI D + LT+ V T++YRAPE+++ S Y+ A+D+WS+GC AE+L R LF K L+QL+LILN++G+P D LC + AR Y L KP I +S N +AL L++++L FNP+ RI+ EEAL+H YL+
Sbjct: 27 IGEGAYGMVVAGVDNTTGERIAIKKISPFEHQTY-CQRTLREIKILSRFKHENIIGILDIIRAPRAEDMKDIYIVQPLMETDMYKLLKT-QRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILAEMLANRPLFPGKHYLDQLNLILNVLGSPIADDLLCIKNEKARSY-LQSLPYKPKTPFIKLFS-NADAKALDLIENLLAFNPNKRITVEEALAHPYLE 310
BLAST of NLK-1 vs. Ensembl Nematostella
Match: EDO40573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6R5]) HSP 1 Score: 244.202 bits (622), Expect = 1.630e-73 Identity = 146/374 (39.04%), Postives = 210/374 (56.15%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLAR------IEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNP 1673
+G GA+GVV S D RT K A+K+I F TA+R +REL IL H KH+NII + DI+K + D++Y++ D M++DLH+II + Q L+ +HV+ FLYQILRG+KY+HSA ++HRD+KP N+LVN N LKI DFG+AR +E KR +T+ V T++YRAPEL++ + Y+ A+DMWS+GC AE++ RR LF L QL +IL++ GTP + + L++ K + K+ EA+ LL ML+ +P RI+ E AL H +L + YHS + EP C P +D F + KE +K+ I N + Q + LVL+P
Sbjct: 29 IGNGAYGVVCSAMDTRTGAKVAVKKISRAFDVLTTARRTHRELKILRHFKHDNIICIRDILKPPVNLDEFDDVYVVLDLMESDLHRIIHTDQPLTTEHVRYFLYQILRGLKYIHSAKVLHRDLKPSNLLVNENAELKIGDFGMARGLCSSPLEQKRF---MTEYVATRWYRAPELMLSLNEYSEAIDMWSVGCILAEMIGRRPLFPGANYLNQLQMILSVTGTPSQNFIERMGAERVKTYLNQLPHKDPVPF-EKFFPKAHPEAINLLSQMLQLDPKERITVENALQHPFLKE----YHSE------------------------EDEPTCYSP----LDFKFDTVLMTKEALKEAIVNEIKDFQKKQALVLSP 366
BLAST of NLK-1 vs. Ensembl Nematostella
Match: EDO39421 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA30]) HSP 1 Score: 215.312 bits (547), Expect = 8.791e-64 Identity = 116/307 (37.79%), Postives = 180/307 (58.63%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYREL-FILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEV----VTQYY------RAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHS 1451
++ LG GA+G+VW D RT + A+K+I + F N A+R +RE+ F+ HEN++ L++++K+D+ + +IY++ ++M TDLH +I L H + +YQ+L+ K++HS ++IHRD+KP N+L++S C KICDFGLA R++S +TQE +T Y RAPE+L+ S Y VDMWSIGC ELL + LF L Q++ I+ + P D+ VL + KP + A N +A+ LL+ +L+FNPD R+++EEALSH Y+ R+H+
Sbjct: 16 KKRLGKGAYGIVWKAIDRRTGEVVAVKKIFDAFRNQTDAQRTFREICFLQEFGDHENVVKLMNVIKADN---DKDIYLVFEYMDTDLHNVIKRGNILKDIHKRYIMYQLLKATKFIHSGNVIHRDLKPSNLLLDSECFAKICDFGLA-----RSVSNITQEAGDPSLTDYVATRGILRAPEILLASPRYTKGVDMWSIGCILGELLLGKPLFPGSSTLNQIEKIMTSIAPPSRQDVDSIKSHYSTSVLDRMACKPKRSL-ADVLNTAPSDAIDLLNKLLQFNPDKRLTAEEALSHPYV----ARFHN 309
BLAST of NLK-1 vs. Ensembl Nematostella
Match: EDO46881 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNM4]) HSP 1 Score: 210.305 bits (534), Expect = 3.167e-61 Identity = 128/341 (37.54%), Postives = 193/341 (56.60%), Query Frame = 3
Query: 510 GCYAPILLNNKCEDNTLWER--PLGYGAFGVVWSVF-------DPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFIN-DEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPD-ARYYV--LSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSK 1493
G Y L+N E ++ P+G GA+G V S +P A+K++ F +T+ AKR YREL +L H++HEN+ISL+D+ + +F + ++Y++ + M +DL+ I+ Q LS +HV+ +YQILRG+KY+HSA +IHRD+KP N+ VN +C LKI DFGLAR+ D + +T V T++YRAPE+++ +Y VD+WS+GC AELL + LF ++QL I+ +VG P L + AR Y+ + +K P ++ A+ LL+ ML + DHRI++ EALSH YL CS D D +
Sbjct: 7 GFYRTELVNTVYEVPRKYQELSPIGTGAYGQVCSSTITEPDPTNPDGPNTVAIKKLSRPFQSTMHAKRTYRELKLLRHMRHENVISLLDVFTTASAFEHFQDVYMVTELMGSDLNGILRF-QKLSDEHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELKILDFGLARMTD----AEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTSKTLFPGNDHIDQLTKIMQLVGKPSDDFLQKIDSESARNYIAQMPDYRKTP----FDEYFVGANPLAVDLLEKMLNLDTDHRITAVEALSHPYLASYADPNDEPTCSTFDDSFDEKE 338
BLAST of NLK-1 vs. Ensembl Medaka
Match: nlk1 (serine/threonine-protein kinase NLK2 [Source:NCBI gene;Acc:101168711]) HSP 1 Score: 418.698 bits (1075), Expect = 1.185e-139 Identity = 201/383 (52.48%), Postives = 272/383 (71.02%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSV 1712
+RP+GYGAFGVVWSV DPR +K ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ +EIY++ + MQ+DLHK+IVSPQ L+ DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYRAPE+LM +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTPPL+ L A AR ++L K P+L ++ S+ T EA+ LL ML F+P RIS +ALSH YLD+ RLRYH+CMC CC+ S P+ R + D EP+ +P S + +NS + + KE I +FI + Q R+ L +NP S ++ + S+
Sbjct: 30 DRPIGYGAFGVVWSVTDPRDGRKVALKKMPNVFQNLVSCKRVFRELRMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQSDLHKVIVSPQPLTTDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCLLKICDFGLARVEEPDQSRHMTQEVVTQYYRAPEVLMGCRHYGSAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPPLSALASACEGARAHILRGPHKPPSLSVLYMLSDGATHEAVHLLCRMLVFDPAKRISGSDALSHPYLDEGRLRYHTCMCQCCY-----SVPSG---RVYTRDFEPVAERPFSHSYENSLLSVWQGKELIHRFITEHQQGK--RVPLCINPQSAAFKTFIRSTA 402
BLAST of NLK-1 vs. Ensembl Medaka
Match: nlk1 (serine/threonine-protein kinase NLK2 [Source:NCBI gene;Acc:101168711]) HSP 1 Score: 419.853 bits (1078), Expect = 3.195e-139 Identity = 201/383 (52.48%), Postives = 272/383 (71.02%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSV 1712
+RP+GYGAFGVVWSV DPR +K ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ +EIY++ + MQ+DLHK+IVSPQ L+ DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYRAPE+LM +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTPPL+ L A AR ++L K P+L ++ S+ T EA+ LL ML F+P RIS +ALSH YLD+ RLRYH+CMC CC+ S P+ R + D EP+ +P S + +NS + + KE I +FI + Q R+ L +NP S ++ + S+
Sbjct: 91 DRPIGYGAFGVVWSVTDPRDGRKVALKKMPNVFQNLVSCKRVFRELRMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQSDLHKVIVSPQPLTTDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCLLKICDFGLARVEEPDQSRHMTQEVVTQYYRAPEVLMGCRHYGSAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPPLSALASACEGARAHILRGPHKPPSLSVLYMLSDGATHEAVHLLCRMLVFDPAKRISGSDALSHPYLDEGRLRYHTCMCQCCY-----SVPSG---RVYTRDFEPVAERPFSHSYENSLLSVWQGKELIHRFITEHQQGK--RVPLCINPQSAAFKTFIRSTA 463
BLAST of NLK-1 vs. Ensembl Medaka
Match: nlk1 (serine/threonine-protein kinase NLK2 [Source:NCBI gene;Acc:101168711]) HSP 1 Score: 419.853 bits (1078), Expect = 3.195e-139 Identity = 201/383 (52.48%), Postives = 272/383 (71.02%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSV 1712
+RP+GYGAFGVVWSV DPR +K ALK++PN+F N V+ KR++REL +L KH+N++S +DI++ +EIY++ + MQ+DLHK+IVSPQ L+ DH+K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNCLLKICDFGLAR+E+ +TQEVVTQYYRAPE+LM +Y A+D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTPPL+ L A AR ++L K P+L ++ S+ T EA+ LL ML F+P RIS +ALSH YLD+ RLRYH+CMC CC+ S P+ R + D EP+ +P S + +NS + + KE I +FI + Q R+ L +NP S ++ + S+
Sbjct: 91 DRPIGYGAFGVVWSVTDPRDGRKVALKKMPNVFQNLVSCKRVFRELRMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQSDLHKVIVSPQPLTTDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCLLKICDFGLARVEEPDQSRHMTQEVVTQYYRAPEVLMGCRHYGSAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPPLSALASACEGARAHILRGPHKPPSLSVLYMLSDGATHEAVHLLCRMLVFDPAKRISGSDALSHPYLDEGRLRYHTCMCQCCY-----SVPSG---RVYTRDFEPVAERPFSHSYENSLLSVWQGKELIHRFITEHQQGK--RVPLCINPQSAAFKTFIRSTA 463
BLAST of NLK-1 vs. Ensembl Medaka
Match: nlk2 (nemo like kinase [Source:NCBI gene;Acc:101162387]) HSP 1 Score: 419.083 bits (1076), Expect = 2.766e-138 Identity = 199/390 (51.03%), Postives = 275/390 (70.51%), Query Frame = 3
Query: 564 ERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDP 1733
+RP+GYGAFGVVWSV DPR K+ ALK++PN+F N V+ KR++REL +LS KHEN++S +D+++ H +EIY++ + MQ+DLHKIIVSPQ LS DH K+FLYQILRG+KYLHSA I+HRDIKPGN+LVNSNC+LKICDFGLAR+E+ +TQEVVTQYYRAPE+LM S +Y+ ++D+WS+GC FAELL RRILFQA+ P++QLDLI +++GTP + + A AR ++L K+P+L ++ S+ T EA+ LL ML F+P RIS+++AL+H YLD+ RLRYH+CMC CC+ R + D EP+ + + T + + KE I +F+ Q+ R+ L +NP S ++ ++S+VAQ E P
Sbjct: 141 DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLSFFKHENVLSALDVLQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHAKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEESDESRHMTQEVVTQYYRAPEILMGSRHYSNSIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSMEAMRTACEGARAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCYTTSSG--------RVYTSDFEPVTNAKFDDGFEKNLTSVRQVKEIIHQFVLE--QQKGSRVPLCINPQSAAFKSFISSTVAQPSEMP 520
BLAST of NLK-1 vs. Ensembl Medaka
Match: mapk7 (mitogen-activated protein kinase 7 [Source:NCBI gene;Acc:101157651]) HSP 1 Score: 254.603 bits (649), Expect = 1.481e-71 Identity = 154/381 (40.42%), Postives = 218/381 (57.22%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSD--HSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLAR---IEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPP--LTDLCHAHPDARYYV--LSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKF----IKNYYQKDQY-RLRLVLNP 1673
+G GA+GVV S ++ A+K+I N F AKR REL IL H KH+NII++ DI++ + HS +Y++ D M++DLH+II S Q L+ +H + FLYQ+LRG+KY+HSA++IHRD+KP N+LVN NC LKI DFG+AR + + S +T+ V T++YRAPELL+ ++Y+ A+D+WS+GC FAE+L R+ LF K + QL LIL+++GTPP L A R YV L R P ++K +AL LL +ML+F+P RI EAL H YL +YH D EPIC D F K++ +KE IK I+++++K Q R +L P
Sbjct: 71 IGTGAYGVVSSARRRDNGQQVAIKKISNAFEVVTNAKRTLRELKILKHFKHDNIIAIKDILQPNLPHSAFK-SVYVVLDLMESDLHQIIHSTQTLTPEHTRYFLYQLLRGLKYVHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLSSHPEESYSFMTEYVATRWYRAPELLLSLNHYSLAIDLWSVGCIFAEMLGRKQLFPGKHYVHQLQLILSVLGTPPEGLISAIRAE-RVRSYVQSLPSRTAVP----LSKLYPQAEPDALDLLGAMLRFDPRQRIGVTEALEHPYL----AKYHDP------------------------DDEPIC----VPAFDFEFDKIAMSKEQIKDAILMEIQDFHKKKQSCRQKLQFKP 413
BLAST of NLK-1 vs. Planmine SMEST
Match: SMESG000023289.1 (SMESG000023289.1) HSP 1 Score: 944.495 bits (2440), Expect = 0.000e+0 Identity = 465/465 (100.00%), Postives = 465/465 (100.00%), Query Frame = 3
Query: 354 MLVGQRIHAGVTSLTXXXXXXXXXXXQTELDSKLMRDDKQEEALLAVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 1748
MLVGQRIHAGVTSLTSSKSNNFKSKSQTELDSKLMRDDKQEEALLAVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW
Sbjct: 1 MLVGQRIHAGVTSLTSSKSNNFKSKSQTELDSKLMRDDKQEEALLAVIDEANGCYAPILLNNKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVAQAKEDPTNHKW 465
BLAST of NLK-1 vs. Planmine SMEST
Match: SMESG000014256.1 (SMESG000014256.1) HSP 1 Score: 308.531 bits (789), Expect = 1.721e-95 Identity = 175/448 (39.06%), Postives = 261/448 (58.26%), Query Frame = 3
Query: 483 LLAVIDEANGCYAPILLN----NKCEDNTLWERPLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDH-SFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-------CHAH---PDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVR-NFCID---------------SEPICPKPI------SSTIDNSFTKMSEAKETIKKFIKNYYQKDQYRLRLVLNPNSKNYQPLLTSSVA 1715
LLAV D++N Y N NK + ++PLG GAFGVVW V DPRT +K A+K+I N+F N ++A+R +REL +L +KH N+I L D++ DH + + ++IYILC FM DLH II S + ++ HVK+ YQILRG+KYLHSA+IIHRD+KPGN+LVNS C LKICDFGLAR +++ +T VVTQYYRAPEL++ S Y ++D+WS GC EL ILFQ+ EQL+LIL+IVG P + AH +R ++ ++ ++ N+ ++ + +AL LL ++LKFNP+ R+S+E AL ++ R +H +C+CC +++ D + +F D + P +PI + I + + EA+ I +++YY + + RL+++ N+ + SSVA
Sbjct: 100 LLAVPDQSNN-YMRNAFNFGNYNKIFVSFDGKKPLGNGAFGVVWQVNDPRTNEKMAMKQITNVFSNVMSAQRTFRELTMLMSLKHSNVILLTDVILEDHMNSVANDIYILCQFMDFDLHTIISSKKPIAKFHVKLLFYQILRGLKYLHSANIIHRDLKPGNLLVNSKCQLKICDFGLAR---EKSFESMTPHVVTQYYRAPELILGVSEYTSSIDLWSAGCILVELFTNGILFQSNNTFEQLNLILDIVGCPKIVSQNDDEMKKIGAHLWSKQSRQFMCTQLPRRQNVKFFESLTSEIDMDALYLLINLLKFNPNERLSAETALQSPFVSQGRQLFHGFLCTCCPHSINNTNNGDNLYNMSFTTDKTMINCQNLINQKFLNNPTFFEPIFNGRLFCADISDKMATLEEARMKIHALVQSYYNIEPGKPRLIMS-QFNNHNSFIRSSVA 542
BLAST of NLK-1 vs. Planmine SMEST
Match: SMESG000001435.1 (SMESG000001435.1) HSP 1 Score: 224.557 bits (571), Expect = 1.040e-66 Identity = 123/287 (42.86%), Postives = 188/287 (65.51%), Query Frame = 3
Query: 573 LGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIVKSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKR--NISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDL-CHAHPDARYYVLSKRKKKPNLGMIAKWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYL 1424
+G GA+G+V S +D ++K A+K+I + F +R RE+ IL+ KHENII + DI+ ++ ++YI+ M+TDL K++ + Q LS DH FLYQILRG+KY+HSA+++HRD+KP N+L+N+ C LKICDFGLAR+ D + LT+ V T++YRAPE+++ S Y ++D+WS+GC AE+L + LF K ++QL+LIL ++G+P DL + AR Y L + KP + + + N ++AL L++ +L FNP +RI E+AL+H YL
Sbjct: 25 IGEGAYGMVASAYDNIKKEKVAIKKI-SPFEYQTYCQRTLREIKILTRFKHENIIDIRDIITANSINEMKDVYIVQCLMETDLFKLLKT-QQLSNDHTCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPEHDHTGLLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLNNKPLFPGKHYIDQLNLILGVLGSPNQEDLDSIVNLKARGY-LQQLPYKPKVSWKSLYP-NADDQALDLIEKLLTFNPVNRIGVEDALAHPYL 307
BLAST of NLK-1 vs. Planmine SMEST
Match: SMESG000075533.1 (SMESG000075533.1) HSP 1 Score: 225.328 bits (573), Expect = 1.228e-66 Identity = 131/359 (36.49%), Postives = 198/359 (55.15%), Query Frame = 3
Query: 570 PLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIV---KSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCH-AHPDARYYVLSKRKKKPNLGMIA-KWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNY 1631
P+G+GA+G V + FD + +++ A+K++ FH+ AKR YREL I+ H+ HENI+ L+D + SF ++Y++ M DL+ II + + L+ +HV+ +YQILRG+KY+HS+ IIHRD+KP N+ VN +C LKI DFGLAR D+ +T V T++YRAPE+++ +Y VD+WS+GC AEL R+ LF ++QL I+ + GTP + DAR ++ K + P + W E A+ LLD ML +PD RIS+++AL+H YL D HD D EP P + + + K+T+ FI+N+
Sbjct: 26 PIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKRTYRELKIIHHMDHENIVCLIDAYTPQSTRESF--SDVYLITPLMGADLNAIIRTQELLN-EHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE----MTGYVATRWYRAPEIMLSWMHYTNRVDIWSVGCIMAELFTRKPLFPGNDHIDQLKKIMELAGTPDKEFMNKIVSEDARAFIREKIQTSPRKDFNSFFWQYTKDENAIDLLDRMLVLDPDRRISAKDALAHPYLAD------------YHDEHD----------------EPTAPLFVDVMEGKTDVDLETWKDTVWDFIQNF 349
BLAST of NLK-1 vs. Planmine SMEST
Match: SMESG000075533.1 (SMESG000075533.1) HSP 1 Score: 224.942 bits (572), Expect = 3.051e-66 Identity = 131/359 (36.49%), Postives = 198/359 (55.15%), Query Frame = 3
Query: 570 PLGYGAFGVVWSVFDPRTRKKAALKRIPNIFHNTVTAKRLYRELFILSHIKHENIISLVDIV---KSDHSFINDEIYILCDFMQTDLHKIIVSPQALSVDHVKIFLYQILRGVKYLHSAHIIHRDIKPGNMLVNSNCLLKICDFGLARIEDKRNISPLTQEVVTQYYRAPELLMESSYYAFAVDMWSIGCTFAELLCRRILFQAKGPLEQLDLILNIVGTPPLTDLCH-AHPDARYYVLSKRKKKPNLGMIA-KWSNNVTEEALRLLDSMLKFNPDHRISSEEALSHSYLDDARLRYHSCMCSCCHDHQDSSKPNDGIVRNFCIDSEPICPKPISSTIDNSFTKMSEAKETIKKFIKNY 1631
P+G+GA+G V + FD + +++ A+K++ FH+ AKR YREL I+ H+ HENI+ L+D + SF ++Y++ M DL+ II + + L+ +HV+ +YQILRG+KY+HS+ IIHRD+KP N+ VN +C LKI DFGLAR D+ +T V T++YRAPE+++ +Y VD+WS+GC AEL R+ LF ++QL I+ + GTP + DAR ++ K + P + W E A+ LLD ML +PD RIS+++AL+H YL D HD D EP P + + + K+T+ FI+N+
Sbjct: 50 PIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKRTYRELKIIHHMDHENIVCLIDAYTPQSTRESF--SDVYLITPLMGADLNAIIRTQELLN-EHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE----MTGYVATRWYRAPEIMLSWMHYTNRVDIWSVGCIMAELFTRKPLFPGNDHIDQLKKIMELAGTPDKEFMNKIVSEDARAFIREKIQTSPRKDFNSFFWQYTKDENAIDLLDRMLVLDPDRRISAKDALAHPYLAD------------YHDEHD----------------EPTAPLFVDVMEGKTDVDLETWKDTVWDFIQNF 373 The following BLAST results are available for this feature:
BLAST of NLK-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of NLK-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of NLK-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of NLK-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of NLK-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of NLK-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of NLK-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of NLK-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035424 ID=SMED30035424|Name=NLK-1|organism=Schmidtea mediterranea sexual|type=transcript|length=2307bpback to top protein sequence of SMED30035424-orf-1 >SMED30035424-orf-1 ID=SMED30035424-orf-1|Name=SMED30035424-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=466bp MLVGQRIHAGVTSLTSSKSNNFKSKSQTELDSKLMRDDKQEEALLAVIDEback to top Aliases
The feature 'NLK-1' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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