FMRFamide-activated amiloride-sensitive sodium channel
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035411 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537]) HSP 1 Score: 76.6406 bits (187), Expect = 5.054e-14 Identity = 109/515 (21.17%), Postives = 203/515 (39.42%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHA--QYLNCHTFDISPILQ--NNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCK-ISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
F STS GI +I + R+K RV+WL V + + L Y + +V FP+VT CNL N F+T +G+ + L K T N E+ ++F +++ F+ N + +L S + + C+ + + F H +Y NC TF+ LQ V+ L L N+N D + + +G + +H+P P +G + G +T++ + + + P+G C+P + + ++ SYS C + I K+CGC +P +P E SC+ + L+ I+ K + + +N SC + C Y S S++P++ L++L+ ++ +S R+ I NL+ + I+ + N ++++ +S++ L+ GG ++ G ++I+++E+IE L
Sbjct: 41 FAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNL-------------NRFQT-----DAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREA--TDFAASHQNFSIVEFIRN-KGFYLNNS--TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTD--NPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP----NIKLQNFS-SYSTSGCLKECKAQHIKKQCGC-----------------VPFLLPGYGIECDLQKYFSCVSPV---LDHIEFKDLCTVGTHN----SSCPVSCEEIEYPATISYSSFPSQK-ALKYLSKKLNQS------------RKYI---------------------RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: ASIC1 (acid sensing ion channel subunit 1 [Source:HGNC Symbol;Acc:HGNC:100]) HSP 1 Score: 72.0182 bits (175), Expect = 1.422e-12 Identity = 106/526 (20.15%), Postives = 199/526 (37.83%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFR-ARNKTVRVMW-LFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSL----GYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF----DISPILQ----NNVTTLEMFLYLDEN----MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIE 1698
F S+++ G+ HIF R R +W L F+ +L + C+C ++ Y ++ + + + FP+VT+CNL + +V + + + A +N Y I ++ K NF ++ P F + G+++ + +++C +G SA + + +Y C+TF D P L+ LE+ L + ++ + T F A IK Q +H+ P I+ V PG T + Q I PP+G C T + + SYS ACR +++ C CR + P D P+C+ + C P + ++ C C +PC+ Y + S+ P+K +AK F N++E Q +G+ +D+ ++ N +E+K+ + L GG +++G ++++++E+ +
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTE-RVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEF--RFSQVSKNDLYHAGELLALLNNRYEIPDTQMADE-KQLEILQDKANFRSFK---PKPFNMREFYDRAGHDIRDMLLSCH---FRGEVCSAEDFKV----------VFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQ-------IHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSD--LDFFDSYSITACRIDCETRYLVENCNCRMVHMP---GDAPYCTPEQY----KECADPAL-------DFLVEKDQEYC--------------VCEMPCNLTRYGKELSMVKIPSKASA-----KYLAKKF---NKSE----------QYIGENILVLDIFFEV----------------LNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFD 455
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1D (sodium channel epithelial 1 delta subunit [Source:HGNC Symbol;Acc:HGNC:10601]) HSP 1 Score: 65.4698 bits (158), Expect = 1.745e-10 Identity = 85/375 (22.67%), Postives = 135/375 (36.00%), Query Frame = 1
Query: 562 LESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSM--PIFVPKRNCETPTAINSSCIKQM--TIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTM 1674
L LP+ +E S G +FV++C L CQA +R F H Y +C+T D Q T + L L H + S L+G + VH P + S +V PG+ I+++ + PYG C+ +N SY+ AC Q +++ C C +P + +CSS P + C ++ + +R+ C C PC +++ S WP+ AKS G L +G++ L +Q++ +L + I N VEE V S+ LS G L S+W G ++
Sbjct: 241 LALLPAAWE-DSHGSQDGHFVLSCSYDGLD--------CQARQ----FRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQP-------HLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP-LPAGAEYCSSARHPAW-------------GHCFYRLYQDLETHRLPC------------TSRCPRPCRESAFKLSTGTSRWPS------------AKSAGW-------------TLATLGEQ----GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV 540
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1D (sodium channel epithelial 1 delta subunit [Source:HGNC Symbol;Acc:HGNC:10601]) HSP 1 Score: 65.4698 bits (158), Expect = 1.745e-10 Identity = 85/375 (22.67%), Postives = 135/375 (36.00%), Query Frame = 1
Query: 562 LESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSM--PIFVPKRNCETPTAINSSCIKQM--TIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTM 1674
L LP+ +E S G +FV++C L CQA +R F H Y +C+T D Q T + L L H + S L+G + VH P + S +V PG+ I+++ + PYG C+ +N SY+ AC Q +++ C C +P + +CSS P + C ++ + +R+ C C PC +++ S WP+ AKS G L +G++ L +Q++ +L + I N VEE V S+ LS G L S+W G ++
Sbjct: 241 LALLPAAWE-DSHGSQDGHFVLSCSYDGLD--------CQARQ----FRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQP-------HLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP-LPAGAEYCSSARHPAW-------------GHCFYRLYQDLETHRLPC------------TSRCPRPCRESAFKLSTGTSRWPS------------AKSAGW-------------TLATLGEQ----GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV 540
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1D (sodium channel epithelial 1 delta subunit [Source:HGNC Symbol;Acc:HGNC:10601]) HSP 1 Score: 65.855 bits (159), Expect = 1.807e-10 Identity = 85/375 (22.67%), Postives = 135/375 (36.00%), Query Frame = 1
Query: 562 LESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSM--PIFVPKRNCETPTAINSSCIKQM--TIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTM 1674
L LP+ +E S G +FV++C L CQA +R F H Y +C+T D Q T + L L H + S L+G + VH P + S +V PG+ I+++ + PYG C+ +N SY+ AC Q +++ C C +P + +CSS P + C ++ + +R+ C C PC +++ S WP+ AKS G L +G++ L +Q++ +L + I N VEE V S+ LS G L S+W G ++
Sbjct: 405 LALLPAAWE-DSHGSQDGHFVLSCSYDGLD--------CQARQ----FRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQP-------HLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP-LPAGAEYCSSARHPAW-------------GHCFYRLYQDLETHRLPC------------TSRCPRPCRESAFKLSTGTSRWPS------------AKSAGW-------------TLATLGEQ----GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV 704
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: del-4 (DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P91835]) HSP 1 Score: 88.1965 bits (217), Expect = 3.789e-18 Identity = 113/517 (21.86%), Postives = 205/517 (39.65%), Query Frame = 1
Query: 187 TSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNN--YGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNN----VTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNK---DVVESCSL--PCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
TS G+PHI A + +R W+ V I + I LL YL F+V + ++ A FP+VT+C+L P + + + Y DS++ +G+ L ++++ + + TL + L N + + Y+ + V++C +A C + F + Y NC F+ + ++ + L M + D++ ++ SG +I +H P + PG+ + + + + + + PYG C+ KT Y +Y+ AC + +Q +II CGC Y S + S C+ L+ + C + +IN + DV+ C PC SY S + WP+ +S V TE P G + +D Y+ N + L+ + +R NF + + E + +F+S GG ++LG+++IS +E + L+
Sbjct: 19 TSTHGVPHIGMANARWLRAFWILVVVVSIALFIWQFITLLTNYLSFSV-NTETTLQFAERTFPTVTICHLNPWKLSETKSVDPDMSALIDAYNSDSSSAQFGLPASLTADRQQQASKW--TLMYSERLNEKQYN-DAADIAYSYDDMVVSCTY--------NAKTCNI----TDFNDFYNPSYGNCLQFNTDGMYSSSRAGPLYGLRMVMRTDQDTYLP----------WTEASGVIIDIHMQDEIPYPDVFGYFAPPGTASSLGVSYVQTTRLSKPYGSCTTKTKLKTTH--YTGTYTVEACFRSCMQEKIIASCGCYYPAYSHASNTTQYVS----------CDNGVQ-----------TLSNLNC-VDLINSADSTEFDVLTDCDCPQPCEIDSYGVTVSTAQWPS--------DSYVP--------TECNPGGPSGPWDASG--ESCLD-WYKANTI---LIEIYYERMNFQV--LTESPAYTFVNFISDVGGQVGLFLGMSIISAIEYLVLI 461
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: asic-2 (Degenerin-like protein asic-2 [Source:UniProtKB/Swiss-Prot;Acc:Q22851]) HSP 1 Score: 73.1738 bits (178), Expect = 2.449e-13 Identity = 99/539 (18.37%), Postives = 214/539 (39.70%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRP----ISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVT------TLEMFLYLDEN-MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVN----CCGGGRPHRDPN 1746
F +++ +PH+ A NK R+ W+ ++ + + L+ ++ + +++ + FP VTVCN+ P + N+ T + A ++ L + + Y + + +L S+ + Y ++ + +C + + S+ + +FI Y C++F+ L +V+ L++ L + + N NT + ++L+GA I V++ G+ P ++ I+ G + +++ N++ PYG C + P + Y + Y+ C Q + I KC C STD C+ P + C++ + I ++ + N C+ PC +Y S++ +P+ + ++ + G + T + + QK Y N + ++ + ++ ++ L+ E ++++ ++ GG +WLGL++IS+VE+ L++ C GG P+
Sbjct: 13 FSNWSTVAVVPHVANANNKISRIFWIAIFLFVLGMFAYELYILIAKFFSYPATVNTEILFE-KQIFPVVTVCNMNPYKYSVVKSNSAFSSVNTLMTTYSDATVGTFSTDKWGLYADNDETYDLDSRAADALVLEANLISDTAKVPALYTYADLIQDCSFAGIPCSESD------------FTKFIDPVYGACYSFNEDASLNYSVSREGIQFGLKLMLTVTQTKTNGNT-----DSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKKPYGTCVDREPDSSDYY-KDFIYTLETCFNGCKQRDTIAKCQCANPRLALGSTDTA-------------CQ-PIKADLDCLQTLKGNQTSSTPNIDLLVECN------CNPPCDESTYTPTVSLAQFPSTSY---YVATSSTAGVGSCSSTN-SKFSSKSDCQK----------WYNNNGM---IIQVFLETLSYELYT--ETAGYTVSNVINDLGGQAGLWLGLSVISVVEMTGLMLVMGAFCVTGGAIKMAPD 493
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-8 (Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:Q21974]) HSP 1 Score: 66.6254 bits (161), Expect = 3.677e-11 Identity = 78/378 (20.63%), Postives = 139/378 (36.77%), Query Frame = 1
Query: 589 RKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI--SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCC 1716
R++L Y L+ FV+ C + S + YG NC+TF+ S L+N+ L L N++ + + ++ +G + VH P + + G ++ L+ + + P+G CS Y+Y N YS C + Q ++++ CGC +P S + R+C + I+ C+ +T S + + E C PC +ET S S WP++ +++ V+ F + EA Y+ +N + I N ++E +L + S GG +W+G ++I+ E EL C
Sbjct: 410 RRNLSYTLNEFVLRCSFNSKDCSMERDFKLHVDPEYG-----------NCYTFNFNDSVELKNSRAGPMYGLRLLLNVHQSDYMP------TTEAAGVRLVVHEQDQEPFPDTFGYSAPTGFISSFGLKTKELHRLSAPWGNCSDTFRPVPYIY--NEHYSPEGCHRNCFQLKVLEICGCGDPRFPLPSEE------------HRHCNAKSKIDRQCLSNLT--------SDSGGYHHLHEQCE-CRQPCHEKVFETAYSASAWPSQNFKIGTDCPAVSDIFN---------------------DTEACTEYYR-----QNTAYIEIYYEQLNFESLKETAGYTLVNLFSDFGGNIGLWIGFSVITFAEFAELFCEIC 721
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-8 (Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:Q21974]) HSP 1 Score: 66.6254 bits (161), Expect = 3.731e-11 Identity = 78/378 (20.63%), Postives = 139/378 (36.77%), Query Frame = 1
Query: 589 RKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI--SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCC 1716
R++L Y L+ FV+ C + S + YG NC+TF+ S L+N+ L L N++ + + ++ +G + VH P + + G ++ L+ + + P+G CS Y+Y N YS C + Q ++++ CGC +P S + R+C + I+ C+ +T S + + E C PC +ET S S WP++ +++ V+ F + EA Y+ +N + I N ++E +L + S GG +W+G ++I+ E EL C
Sbjct: 369 RRNLSYTLNEFVLRCSFNSKDCSMERDFKLHVDPEYG-----------NCYTFNFNDSVELKNSRAGPMYGLRLLLNVHQSDYMP------TTEAAGVRLVVHEQDQEPFPDTFGYSAPTGFISSFGLKTKELHRLSAPWGNCSDTFRPVPYIY--NEHYSPEGCHRNCFQLKVLEICGCGDPRFPLPSEE------------HRHCNAKSKIDRQCLSNLT--------SDSGGYHHLHEQCE-CRQPCHEKVFETAYSASAWPSQNFKIGTDCPAVSDIFN---------------------DTEACTEYYR-----QNTAYIEIYYEQLNFESLKETAGYTLVNLFSDFGGNIGLWIGFSVITFAEFAELFCEIC 680
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-8 (Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:Q21974]) HSP 1 Score: 66.2402 bits (160), Expect = 4.442e-11 Identity = 78/378 (20.63%), Postives = 139/378 (36.77%), Query Frame = 1
Query: 589 RKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI--SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCC 1716
R++L Y L+ FV+ C + S + YG NC+TF+ S L+N+ L L N++ + + ++ +G + VH P + + G ++ L+ + + P+G CS Y+Y N YS C + Q ++++ CGC +P S + R+C + I+ C+ +T S + + E C PC +ET S S WP++ +++ V+ F + EA Y+ +N + I N ++E +L + S GG +W+G ++I+ E EL C
Sbjct: 409 RRNLSYTLNEFVLRCSFNSKDCSMERDFKLHVDPEYG-----------NCYTFNFNDSVELKNSRAGPMYGLRLLLNVHQSDYMP------TTEAAGVRLVVHEQDQEPFPDTFGYSAPTGFISSFGLKTKELHRLSAPWGNCSDTFRPVPYIY--NEHYSPEGCHRNCFQLKVLEICGCGDPRFPLPSEE------------HRHCNAKSKIDRQCLSNLT--------SDSGGYHHLHEQCE-CRQPCHEKVFETAYSASAWPSQNFKIGTDCPAVSDIFN---------------------DTEACTEYYR-----QNTAYIEIYYEQLNFESLKETAGYTLVNLFSDFGGNIGLWIGFSVITFAEFAELFCEIC 720
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic1a (acid-sensing (proton-gated) ion channel 1a [Source:NCBI gene;Acc:791696]) HSP 1 Score: 76.2554 bits (186), Expect = 3.657e-14 Identity = 98/523 (18.74%), Postives = 209/523 (39.96%), Query Frame = 1
Query: 172 LFCQSTSIRGIPHIFRARNKTVRV-MWL-FFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQ--YLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTT-------LEMFLYLDENMNSNTCIDCFHAEIKSQL-SGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
+F ++++ GI HIF T + +W+ FF+S+L +C I ++ YLE+ + I FP+VT+CNL I + R+ + + + A ++ + ++ +L++++ + + T +F ++ + R G+++ + +++CQ +GS C+ + +Y C+TF+ V+ LE+ L ++ + + + +S +G + +H+ P I+ V PG T ++ Q + P+G C P + Y Y++S ACR +++ C CR + P D P+C+ P+ + C P + + + + D SC PC+ Y + S P+K +++L + +KS + N++ L + N +E+++ + L GG +++G ++++++E+ + L
Sbjct: 25 VFAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVC-IDRIQFYLEYPHVTKLDEITTPVMVFPAVTICNLNSI--RFSRITRNDLYHAGELLALLNSRHEVREAHLVEESVMEVLKSKTDFRSFKPRHFNMWEFYNRT--GHDIKDMLLSCQ---FRGS-----PCRPED-----FSVVFTRYGKCYTFNSGETGPPRVSVKGGMGNGLEIML----DIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAYSIS----ACRTDCETRYLVENCNCRMVHMP---GDAPYCT--PVLY--KECAHPA--------------------LDFLVETDSDYC-SCETPCNITRYSKELSFVKIPSKA-SVKYLAKKYSKS---------------------------------EKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYL 459
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic1b (acid-sensing (proton-gated) ion channel 1b [Source:NCBI gene;Acc:407672]) HSP 1 Score: 65.0846 bits (157), Expect = 1.303e-10 Identity = 103/537 (19.18%), Postives = 194/537 (36.13%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKK---------NKRKDYTTYTGTLNFPAYL----ESLPSNFER-KSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQF--IHAQYLNCHTF----DISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQL-SGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
+E LF + T+ G+ H+F + + RV WL + +R L V ++ FP+VT+CN + P+ R+ + + F R N+ + ++ N ++ ++ L F +L +S PS + LG+ L ++ C+ Q Q P R F I +Y C+TF D P+L + L + ++ + + + ++ +G + +HT P I+ V PG T ++ Q PP+G C + + Y+++ ACR +++ C CR + P D P+C+ + C P + + + + D C PC+ Y + S P+K +AK + N+TE + N++ L I N +E+K+ L L GG +++G ++++++E+ + L
Sbjct: 17 KEAGKLFLKHTTFHGLRHVFLSGSYPRRVAWLLAFLTALALLFTWSSNRVRYLLSSPVYTKAHMVYAKRLVFPAVTICNKNILLPR--RMKKPDIFSAGRWLGIFGKNWQVSAAVRDALASLDDGTNVDPPWSPFSRILEFNHFLPPPRDSQPSMRQLLDRLGHQLEEMLLYCRF-----------QGQLCGP----RNFSTIFTRYGKCYTFNSGQDGRPLLITTKGGMGNGLEIMLDIQQDEYLPVWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKATPIDSDFFNTYSIT----ACRIDCETRYLVENCNCRMVHMP---GDAPYCTPEQY----KECADPA--------------------LDFLVERDNDYC-VCETPCNMTRYGKELSFVRIPSKASA-----KYLAKKY---NKTE--------------------------QYISDNIMVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYL 470
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537]) HSP 1 Score: 72.4034 bits (176), Expect = 9.976e-13 Identity = 106/518 (20.46%), Postives = 201/518 (38.80%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFR----ARNKTVR-VMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQA-GTP-YGTWRQFIHAQYLNCHTFDISPILQNN-VTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
F STS G+ ++ +N R +W VS II C + + Y + V N FP++T CNL N F+T + NN I + L N +T + P ++ + ++F + + +++ F N +L S + ++C G P Y + I +Y NC+TF+ + + N +TT L + ++ D + +G +H+P P +G ++ G ++++ + + P+G C+P Y+ YS + C Q I +CGC +P +P E +C+ + + K ++ + YN +C +PC + S ST+P+ ++L+++++KS LY N NL+ + I N +++++ L+ + LS GG ++ G +MI+++E++E L
Sbjct: 40 FATSTSFHGVHNLVENGGSGKNSKFRTAIWTSVVSVFIIMACWQVCTRVINYFSWPTTTSVNVQYVENIDFPAITFCNL-------------NRFQT-----KAVNNLSIAFFLW-NIVSAVLHFTSIASDPGEMQEV-TDFLKLNKNFSIKEFTKNYGF-YLNNS--TLLKCSFFGYPCYPEDFEHIFTEYGNCYTFNYNTVSMNKRITTAGRGLSVLFDIKQTEFTD--EPSLGFVDAGISFVLHSPLVPPRFDGLGLHSPAGMHAHVSMRRFKTVIQEHPWGECNPSLK-----LKYHEIYSTYGCLQECKSYYIQNECGC-----------------IPFLLPGNGKECDLQQLYNCVSRALYTIE--KSELCSMGTYNS----TCPVPCEETDFPATISYSTFPSDK-AAQFLSAKLSKS-----------------------------ALYMRN----NLVYIDIKYHEMNYKIMKQQKALTASELLSNIGGQLGLFCGASMITIIEILEYL 470
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: lhx1 (LIM homeobox 1 [Source:Xenbase;Acc:XB-GENE-482482]) HSP 1 Score: 69.3218 bits (168), Expect = 3.806e-12 Identity = 82/340 (24.12%), Postives = 134/340 (39.41%), Query Frame = 1
Query: 70 TWYYPTRNIQIPTDEYDVISLKYQGCSNWREETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALI---IGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPI--SPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLN-FPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI--SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIK-----SQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGY 1050
T YYP + P YD +L+ G T L Q TS GIP+IFR+++ R++WL FVS + + C M+ Y I +I A FP+VT+CNL + S G NS + N + + + Y N F + LP ++ +G+ L + +I C +C + G FI+ ++ NC+TF+ S ++ N ++ ++ F +I+ + +G + VH P +NV PG+ TEI + + I P+ +VY+Y Y
Sbjct: 9 TMYYPEMKVVKPP--YDANTLRKLG------RTTL--QHTSAHGIPNIFRSKHWFRRMVWLVFVSFALCCALWQCTQMVLTYYTYPSHEKI---MLISSAKLKFPAVTICNLNSVRLSSLGRSFSMSNSLQDSGLEMTHRRNRSHHMNVTSDSVDENVLYASAFNKFASEFNQLPDE-QKIEMGHQLEDMLIFCNF--------HGQECNSSFFSG----FINYKFGNCYTFNSQKSVDIRGNQIRVDPLNITKAGFMYGLHLELFIQQIEYVRDMTHAAGIRLLVHDQAQMPFPEDEGVNVPPGAETEIGMMKVQLI--------VCPEHSLSVYLYLY 314
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cdh12 (cadherin 12, type 2 (N-cadherin 2) [Source:Xenbase;Acc:XB-GENE-982876]) HSP 1 Score: 69.707 bits (169), Expect = 9.444e-12 Identity = 78/383 (20.37%), Postives = 147/383 (38.38%), Query Frame = 1
Query: 586 ERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTT-------LEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVV---ESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
++ ++GY ++ C F G + C A + F H Y NC+TF+ + V++ L++ LY+DE+ + S +GA I VH +P I + + T I +Q + + + PY C+ Y+ Y+ C Q E+++ CGC + P + +C+ E P+ I C + Q+ ++ + +C CSF + RS++ WP+ LNS V ++ +++L VG ++ L N+ ++L N + E ++ + LS GG +W+ +MI ++E++E+
Sbjct: 248 DKIAMGYKADELIVTC---FFDG-----LSCDARN----FTLFHHPLYGNCYTFNSAERGNLLVSSMGGAEYGLKVVLYIDEDE---------YNPYLSTAAGAKILVHDQDEYPFIEDLGTELETATETSIGMQLTESTKLSDPYSDCTMDGSDVSVENLYSKKYTLQICLNSCFQREMVRTCGCAHYDQP-LPNGAKYCNYE---------EYPSW---------------IYCYFKLYKQFVQEELGCQSACRESCSFKEWTLTRSLAKWPS-------LNSEVRSAW-------------VLQLFYVGHGFFNLNDLANLNIFYQDL----------NSRSISESPTYNIVTLLSNFGGQLGLWMSCSMICVLEIVEVF 554
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cdh12 (cadherin 12, type 2 (N-cadherin 2) [Source:Xenbase;Acc:XB-GENE-982876]) HSP 1 Score: 67.3958 bits (163), Expect = 5.153e-11 Identity = 77/383 (20.10%), Postives = 146/383 (38.12%), Query Frame = 1
Query: 586 ERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTT-------LEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVV---ESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
++ ++GY ++ C F G + C A + F H Y NC+TF+ + V++ L++ LY+DE+ + S +GA I VH +P I + + T I +Q + + + PY C+ Y+ Y+ C Q E+++ CGC + P + +C+ E P+ I C + Q+ ++ + +C CSF + RS++ WP+ L +W+ ++ G +K+ K N+ + +L L I + N + E ++ + LS GG +W+ +MI ++E++E+
Sbjct: 256 DKIAMGYKADELIVTC---FFDG-----LSCDARN----FTLFHHPLYGNCYTFNSAERGNLLVSSMGGAEYGLKVVLYIDEDE---------YNPYLSTAAGAKILVHDQDEYPFIEDLGTELETATETSIGMQLTESTKLSDPYSDCTMDGSDVSVENLYSKKYTLQICLNSCFQREMVRTCGCAHYDQP-LPNGAKYCNYE---------EYPSW---------------IYCYFKLYKQFVQEELGCQSACRESCSFKEWTLTRSLAKWPS-LNSEQWMLRVLSWELG----------------EKLNK-----------NLTKNDLANLNIFYQDLNSRSISESPTYNIVTLLSNFGGQLGLWMSCSMICVLEIVEVF 564
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: copg2 (coatomer protein complex subunit gamma 2 [Source:Xenbase;Acc:XB-GENE-941264]) HSP 1 Score: 62.003 bits (149), Expect = 1.815e-9 Identity = 61/288 (21.18%), Postives = 113/288 (39.24%), Query Frame = 1
Query: 859 SQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFC--SSMPIFVPKRNCETPTAINSSCIKQMTIAL--NRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVN 1710
SQ +GA I +H P P + + ++ PG+ I+++ I+ Y +C+ YN SY+ AC Q ++I+ CGC YP + + +C + P + C Q+ + + + C C C Y + WP+ + S+V+ + + + Y + EL + K +++ Y+ + VEE +S+T LS GGL+S W G +++S+ E+ EL+++
Sbjct: 303 SQAAGARIMIHNPNQPPLVEHQGFDIRPGTENSISVKQEEAIRLGGKYSQCTSDGSDLGIKILYNTSYTMQACLNSCFQYKMIEVCGCGYYFYP-LPPGMEYCNYNKHPDW-------------GYCFYQLYEKMLDHTLIC------------FTQCPKQCKQTEYHLSAGTAKWPSPV-------SKVSNDYITIKA---KVYWGVWELSDISK----INVYYE----------------ELSYRSVEETPSVSVTMLLSSMGGLWSWWFGSSVLSVAEIAELVLD 534
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic5 (acid-sensing (proton-gated) ion channel family member 5 [Source:MGI Symbol;Acc:MGI:1929259]) HSP 1 Score: 80.1073 bits (196), Expect = 2.802e-15 Identity = 105/521 (20.15%), Postives = 199/521 (38.20%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIF----LLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHA--QYLNCHTFDISPILQNNVTT------LEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIK-CKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIE 1698
F STS GI +I + +NK +V+WL A+++G +++ L Y + +V FP+VT+CNL N F+T + + +GI + L K + N E+L +F ++++ FV N + + V C+ + + F H +Y NC TF+ +QN L++ L + + ++ + F +G + +H+P P +G ++ G +T++ + + + P+G C+P + ++YS + C +K+C R I+ C +P +P E +C+ + + R C + N SC + C Y S ST+P S+ A F + Q Y R NL+ + I+ + N ++++ +S+ L+ GG ++ G ++I+++E+IE
Sbjct: 41 FAMSTSFHGIHNIAQNQNKVRKVIWL----AVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCNL-------------NRFQT-----EAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETL--DFVTNHQNFSITEFVKNNGFYL---NNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFAD------AGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNF-----ITYSTYGC---------LKECKARHIQR--------LCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHN-------SSCPVSCEETEYPATVSYSTFP----------SQRATRFLAKKLNQSQEYIR------------------------ENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIE 465
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic5 (acid-sensing (proton-gated) ion channel family member 5 [Source:MGI Symbol;Acc:MGI:1929259]) HSP 1 Score: 77.7962 bits (190), Expect = 1.275e-14 Identity = 104/518 (20.08%), Postives = 198/518 (38.22%), Query Frame = 1
Query: 184 STSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIF----LLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHA--QYLNCHTFDISPILQNNVTT------LEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIK-CKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIE 1698
STS GI +I + +NK +V+WL A+++G +++ L Y + +V FP+VT+CNL N F+T + + +GI + L K + N E+L +F ++++ FV N + + V C+ + + F H +Y NC TF+ +QN L++ L + + ++ + F +G + +H+P P +G ++ G +T++ + + + P+G C+P + ++YS + C +K+C R I+ C +P +P E +C+ + + R C + N SC + C Y S ST+P S+ A F + Q Y R NL+ + I+ + N ++++ +S+ L+ GG ++ G ++I+++E+IE
Sbjct: 2 STSFHGIHNIAQNQNKVRKVIWL----AVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCNL-------------NRFQT-----EAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETL--DFVTNHQNFSITEFVKNNGFYL---NNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFAD------AGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNF-----ITYSTYGC---------LKECKARHIQ--------RLCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHN-------SSCPVSCEETEYPATVSYSTFP----------SQRATRFLAKKLNQSQEYIR------------------------ENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIE 423
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic1 (acid-sensing (proton-gated) ion channel 1 [Source:MGI Symbol;Acc:MGI:1194915]) HSP 1 Score: 70.4774 bits (171), Expect = 2.923e-12 Identity = 103/526 (19.58%), Postives = 201/526 (38.21%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFR-ARNKTVRVMW-LFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSL----GYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF----DISPILQ----NNVTTLEMFLYLDEN----MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIE 1698
F S+++ G+ HIF R R +W L F+ +L + C+C ++ Y ++ + + + FP+VT+CNL + +V + + + A +N Y I ++ K NF ++ P F + G+++ + +++C +G SA + + +Y C+TF D P L+ LE+ L + ++ + T F A IK Q +H+ P I+ V PG T ++ Q I P+G C+ T + + Y+++ ACR +++ C CR + P D P+C+ + C P + ++ C C +PC+ Y + S+ P+K +AK F N++E Q +G+ +D+ ++ N +E+K+ + L GG +++G ++++++E+ +
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTE-RVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEF--RFSQVSKNDLYHAGELLALLNNRYEIPDTQMADE-KQLEILQDKANFRSFK---PKPFNMREFYDRAGHDIRDMLLSCH---FRGEACSAEDFKV----------VFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQ-------IHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSIT----ACRIDCETRYLVENCNCRMVHMP---GDAPYCTPEQY----KECADPAL-------DFLVEKDQEYC--------------VCEMPCNLTRYGKELSMVKIPSKASA-----KYLAKKF---NKSE----------QYIGENILVLDIFFEV----------------LNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFD 453
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782]) HSP 1 Score: 65.855 bits (159), Expect = 1.000e-10 Identity = 82/371 (22.10%), Postives = 134/371 (36.12%), Query Frame = 1
Query: 610 LSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI---SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIK-QMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVN 1710
L +F+ C+ + QA + QF H Y NC+TF+ S + +++ + L L N I + S ++GA + VH ++ NV PG T I+++ YG C+ Y Y++ C Q +IKKCGC I YP + FC + ++ K Q +L+ + C C PCS +Y+ S WP+ Q +W+ F ML ++ Y N + L I N E +++ S LS G +S+W G +++S+VE+ EL+ +
Sbjct: 277 LGSFIFTCRFN------------QAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFI-----PLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYP-KPKGVEFCDYL----------KQSSWGYCYYKLQAAFSLDSLGC------------FSKCRKPCSVTNYKLSAGYSRWPSVKSQ-DWI-------FEML----------------------SLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFD 577
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782]) HSP 1 Score: 65.855 bits (159), Expect = 1.000e-10 Identity = 82/371 (22.10%), Postives = 134/371 (36.12%), Query Frame = 1
Query: 610 LSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI---SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIK-QMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVN 1710
L +F+ C+ + QA + QF H Y NC+TF+ S + +++ + L L N I + S ++GA + VH ++ NV PG T I+++ YG C+ Y Y++ C Q +IKKCGC I YP + FC + ++ K Q +L+ + C C PCS +Y+ S WP+ Q +W+ F ML ++ Y N + L I N E +++ S LS G +S+W G +++S+VE+ EL+ +
Sbjct: 277 LGSFIFTCRFN------------QAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFI-----PLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYP-KPKGVEFCDYL----------KQSSWGYCYYKLQAAFSLDSLGC------------FSKCRKPCSVTNYKLSAGYSRWPSVKSQ-DWI-------FEML----------------------SLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFD 577
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 1.482e-31 Identity = 127/548 (23.18%), Postives = 224/548 (40.88%), Query Frame = 1
Query: 187 TSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYL------DENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFV-STDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVE----SCSLPCSFHSYETDRSVSTWPTKLWQL-----------------------EWLNSRVAKSFGMLNRTEFQP---YRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCG 1719
++ G+ I +R+ +V+W V A + + L+R+YL+F V+ ++ +PSV++CN+ PIS + R + N+ +S N + R + ++ ++ A+ E+L + K L +NL + +++C+ + C + F Y NC TF+ LQ + T E L L D+ + + F I +G + VH PG+ P+ I++ PG + + L+ IL+ + PYG C+ + Y Y FAC Q+ Q II++CGC++ P V S + FC + + + N S + I + C+ N D C PCS SY S+S WP + +QL E+L S L R + + L + KEA DL+ Q N+L L I + ++ + + L + GG +W+G+++++++E+IEL++ G
Sbjct: 50 SNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPISLRTIRRMYFNN---------ESQNLITWLRFIQKFRFEQDSFMNSIR--AFYENLGQ--DAKKLSHNLEDMLMHCRF--------NRELCHV----SNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNILHS-AGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDMLNGIKQYKYTF----FACLQLCKQRLIIQRCGCKSSALPEVPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQ------NMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELVIRLTG 561
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q9R0Y1|ASIC5_MOUSE (Acid-sensing ion channel 5 OS=Mus musculus OX=10090 GN=Asic5 PE=2 SV=1) HSP 1 Score: 80.1073 bits (196), Expect = 1.960e-14 Identity = 105/521 (20.15%), Postives = 199/521 (38.20%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIF----LLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHA--QYLNCHTFDISPILQNNVTT------LEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIK-CKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIE 1698
F STS GI +I + +NK +V+WL A+++G +++ L Y + +V FP+VT+CNL N F+T + + +GI + L K + N E+L +F ++++ FV N + + V C+ + + F H +Y NC TF+ +QN L++ L + + ++ + F +G + +H+P P +G ++ G +T++ + + + P+G C+P + ++YS + C +K+C R I+ C +P +P E +C+ + + R C + N SC + C Y S ST+P S+ A F + Q Y R NL+ + I+ + N ++++ +S+ L+ GG ++ G ++I+++E+IE
Sbjct: 41 FAMSTSFHGIHNIAQNQNKVRKVIWL----AVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCNL-------------NRFQT-----EAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETL--DFVTNHQNFSITEFVKNNGFYL---NNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFAD------AGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNF-----ITYSTYGC---------LKECKARHIQR--------LCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHN-------SSCPVSCEETEYPATVSYSTFP----------SQRATRFLAKKLNQSQEYIR------------------------ENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIE 465
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q9R0W5|ASIC5_RAT (Acid-sensing ion channel 5 OS=Rattus norvegicus OX=10116 GN=Asic5 PE=1 SV=1) HSP 1 Score: 78.1814 bits (191), Expect = 6.169e-14 Identity = 109/521 (20.92%), Postives = 198/521 (38.00%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVRVMWLFFV--SALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHA--QYLNCHTFDISPILQ--NNVTT----LEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIK-CKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
F STS GI +I + +NK +V+WL V S ++ W I L Y + +V FP+VT CNL N F+T + + +GI + L K + N E+L +F ++++ FV N + + V C+ + F H +Y NC TF+ +Q N V+ L++ L + + ++ + F +G + +H+P P +G ++ G +T++ + I + P+G C+P + +YS + C +K+C + I+ C +P +P E +C+ + + R C + N SC +PC Y + ST+P S+ A F + Q Y R NL+ + I+ + N ++++ +S+ L+ GG ++ G ++I+++E+IE L
Sbjct: 41 FAISTSFHGIHNIAQNQNKVRKVIWLSVVLGSVSLLVWQIYS--RLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNL-------------NRFQT-----EAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEAL--DFVASHRNFSITEFVKNNGFYL---NHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFAD------AGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGECNPDIKLRNF-----TTYSTYGC---------LKECKAKHIQR--------LCGCLPFLLPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNS-------SCPVPCEETEYPATIAYSTFP----------SQRATKFLAKKLNQSQEYIR------------------------ENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYL 467
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q9NY37|ASIC5_HUMAN (Acid-sensing ion channel 5 OS=Homo sapiens OX=9606 GN=ASIC5 PE=1 SV=1) HSP 1 Score: 76.6406 bits (187), Expect = 2.427e-13 Identity = 109/515 (21.17%), Postives = 203/515 (39.42%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHA--QYLNCHTFDISPILQ--NNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCK-ISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
F STS GI +I + R+K RV+WL V + + L Y + +V FP+VT CNL N F+T +G+ + L K T N E+ ++F +++ F+ N + +L S + + C+ + + F H +Y NC TF+ LQ V+ L L N+N D + + +G + +H+P P +G + G +T++ + + + P+G C+P + + ++ SYS C + I K+CGC +P +P E SC+ + L+ I+ K + + +N SC + C Y S S++P++ L++L+ ++ +S R+ I NL+ + I+ + N ++++ +S++ L+ GG ++ G ++I+++E+IE L
Sbjct: 41 FAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNL-------------NRFQT-----DAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREA--TDFAASHQNFSIVEFIRN-KGFYLNNS--TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTD--NPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP----NIKLQNFS-SYSTSGCLKECKAQHIKKQCGC-----------------VPFLLPGYGIECDLQKYFSCVSPV---LDHIEFKDLCTVGTHN----SSCPVSCEEIEYPATISYSSFPSQK-ALKYLSKKLNQS------------RKYI---------------------RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q708S7|ASI1A_DANRE (Acid-sensing ion channel 1A OS=Danio rerio OX=7955 GN=asic1a PE=1 SV=1) HSP 1 Score: 76.2554 bits (186), Expect = 2.760e-13 Identity = 98/523 (18.74%), Postives = 209/523 (39.96%), Query Frame = 1
Query: 172 LFCQSTSIRGIPHIFRARNKTVRV-MWL-FFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQ--YLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTT-------LEMFLYLDENMNSNTCIDCFHAEIKSQL-SGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
+F ++++ GI HIF T + +W+ FF+S+L +C I ++ YLE+ + I FP+VT+CNL I + R+ + + + A ++ + ++ +L++++ + + T +F ++ + R G+++ + +++CQ +GS C+ + +Y C+TF+ V+ LE+ L ++ + + + +S +G + +H+ P I+ V PG T ++ Q + P+G C P + Y Y++S ACR +++ C CR + P D P+C+ P+ + C P + + + + D SC PC+ Y + S P+K +++L + +KS + N++ L + N +E+++ + L GG +++G ++++++E+ + L
Sbjct: 25 VFAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVC-IDRIQFYLEYPHVTKLDEITTPVMVFPAVTICNLNSI--RFSRITRNDLYHAGELLALLNSRHEVREAHLVEESVMEVLKSKTDFRSFKPRHFNMWEFYNRT--GHDIKDMLLSCQ---FRGS-----PCRPED-----FSVVFTRYGKCYTFNSGETGPPRVSVKGGMGNGLEIML----DIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAYSIS----ACRTDCETRYLVENCNCRMVHMP---GDAPYCT--PVLY--KECAHPA--------------------LDFLVETDSDYC-SCETPCNITRYSKELSFVKIPSKA-SVKYLAKKYSKS---------------------------------EKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYL 459
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4V3SD10 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009422 PE=3 SV=1) HSP 1 Score: 536.184 bits (1380), Expect = 1.931e-180 Identity = 260/538 (48.33%), Postives = 359/538 (66.73%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYN-VSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPT---------------AINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIEL-QKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCG 1719
++E ILFCQ+T+IRG+ + AR+K+ +++W V L IG CM FL RQYLE++VIHPPQV+RD SPFPS+T+CNLRP++ + +VL+E+ KTPR +A D NN+ + K Y T ++ YLESLP R LG++++ +I+C + + +GS+R C G WR+F+HAQYLNC+++D+ +++V T+E+F+YLD N +C+DCF AEIKSQLSGAV+ VH T+P+IN IN+ PGSLTEI ++ I +IQK PPYGRCSP TPKT+ +YG YSE ACR TIQ +I +CGC AIE+P+ S+ +PFC +M FV + +C+ + ++ S C+ ++ + N + CK V + DVV SC+LPC F SYETDRS STWPTK WQL WL +R + +LNR E PYR +L ++ + A LL QTNVLE+NLLA++I RPNFNLH VEEKEVLSLTS LSQ+GGL SIW+G+ ++S++E+ ELLV+ G
Sbjct: 38 KKELILFCQTTTIRGVTRVVNARSKSFQIVWASSVLFLFIGLFTCMFFLTRQYLEYHVIHPPQVLRDTPSPFPSITLCNLRPLASEATKVLEESRIKTPRKFAMDVNNFAAEAFYHKGDVHSYQLITSAISMGGYLESLPPEI-RLQLGHHMNQTIIHCMVLYSEGSKRVLNDCHQ---VGRWRRFVHAQYLNCYSYDLLEKYRDHVRTIELFVYLDVPPNKTSCVDCFSAEIKSQLSGAVVVVHNADTYPDINQEGINIQPGSLTEIKVKTIKHIQKTPPYGRCSPDTPKTIELYGAAPYRYSEHACRMSTIQTQINDRCGCNAIEFPYRSSSLPFCLAMGSFVHEGSCDVQSLQGSGSKVANSTKIGSLKSECLAELEVVKNHVTCKSDVTRHFEGDVVPSCTLPCQFFSYETDRSTSTWPTKSWQLGWLGTRAGRM--ILNRPELAPYREARDLMRQPNGDVRAQTLLSQTNVLEKNLLAIMIIRPNFNLHNVEEKEVLSLTSLLSQTGGLLSIWIGMNIMSVIELFELLVHLFG 569
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A158QSX4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS1629 PE=3 SV=1) HSP 1 Score: 530.791 bits (1366), Expect = 2.157e-179 Identity = 269/566 (47.53%), Postives = 365/566 (64.49%), Query Frame = 1
Query: 151 NWREETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMY-GYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNC------ETPTAINSS--------CIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEK---EAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHRDPNPRHTDGIRCPHERNFK 1794
++ +E + FCQ+T+IRG+ I +A NK +R +WL FV AL IG CMI L+RQY++++VIHPP+V+RD SPFPS+T+CNLRPISP G + ++ F+ PR +A + N++ +NK DY + ++ YLESLP SLG+ + VI C + +L+GS R QC+ G WR F HA YLNCH+FD+ P + V T+E+F YL+E + C DCF +EIKSQLSGAV+ VHT T+P++N INV PG+LTEI ++ I NIQK PPYGRCS TP + Y + +YSE+ CR +TIQNEI K C C AIE+P + +PFC SM FV + C + A+N++ C KQ+ +A +RI CK V++++ DVV +C+LPC+F+SYETDRS STWPTK WQL WL + + ++ +L E YRR EL +K E + +L + N +ERNLLA+++ RPNFNLHKV EKEV SLTSFLSQ+GGL SIW+GLTMI LVEVIEL++NC + R R D + +N K
Sbjct: 12 SYTQEFLRFCQTTTIRGVSRIVKAPNKGIRSLWLTFVIALFIGLFACMILLVRQYVDYDVIHPPRVLRDTPSPFPSLTLCNLRPISPPGMKKIRNLKFRDPREFANNLNSFAAGLYFYRNKSHDYELVSSAISMGGYLESLPKG-SSYSLGHMRNETVIQCLVLYLEGSSRITEQCEK---VGKWRHFFHALYLNCHSFDLDPSISQQVLTVELFSYLNERHDDVECHDCFASEIKSQLSGAVVVVHTAKTYPDVNQEGINVQPGTLTEIKIKAIENIQKEPPYGRCSLDTPTEIPSYDNISYAYSEYGCRMLTIQNEINKNCNCNAIEFPRMDDTLPFCMSMVDFVKENRCVYEDMVKQAQALNATGPSEEFLLCEKQLNMARDRILCKAQVMHRFQSDVVPTCTLPCAFYSYETDRSTSTWPTKSWQLTWLKTPIGRT--ILQMPEMSEYRRAEELLDQPGDKNRDEVLRILAENNAVERNLLAIMVVRPNFNLHKVAEKEVFSLTSFLSQAGGLLSIWIGLTMICLVEVIELIINCINVFKAKR--RDRRHDRLALQQHKNVK 569
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4Z2CZ76 (FMRFamide-activated amiloride-sensitive sodium channel OS=Schistosoma japonicum OX=6182 GN=EWB00_006254 PE=3 SV=1) HSP 1 Score: 533.487 bits (1373), Expect = 1.248e-178 Identity = 262/555 (47.21%), Postives = 365/555 (65.77%), Query Frame = 1
Query: 160 EETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVS-TDIPFCSSMPIFVPKRNCE-----------TPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHRD-----PNPRHTDGIRC 1773
+E FC++T+IRG+P I RA N+ +R +W V LI G +CM FL RQYLE+NVIHPP+V+R +SPFPSVTVCN RPISP G + LQ +KTPR++ D Y + K ++Y + + +LESLP+N ER+ LGY + +I CQ+++L GS+ A C+ G WR+FIHAQYLNC TF+ L+++ T +EM++YLDE + C+DCFH E+KSQLSGA+I++H T PNIN +SIN+ PG+LTE+ L + NIQ+ PPYGRCS P + ++ +YSE+ACR+ TIQN+I ++CGC ++EYP+ T C+ + F+ +C T T+INS CI + ++R+ CK SVI Y + +C++PCSF+SYE+++S STWPTK WQL WLNS K G+ N TEF+PY L ++G E EA ++L +VLER LLA+LI+RPNF++ KVEEKEVLSLTS LSQ+GGLFSIW+GL+MISL EV+E+ + C + R+ + HT+ + C
Sbjct: 103 DELKRFCENTTIRGLPRIVRAHNRYLRSLWSILVCILIFGCFVCMFFLARQYLEYNVIHPPRVLRHTSSPFPSVTVCNFRPISPDGLKYLQMKGWKTPRHFVLDIATYAQYIFYNRQKIEEYNAASAAFSLAGFLESLPNNEERRKLGYQHNKLIIKCQITYLNGSKPVAAPCERK---GIWRKFIHAQYLNCATFEPFSELRSDTTNIEMYIYLDEMLKRAECVDCFHGEVKSQLSGALISIHGADTLPNINDKSINLKPGTLTELRLSIVENIQQMPPYGRCSKNHPINLNLHDMIYNYSEYACREATIQNDINQRCGCYSMEYPYNEYTGYEPCTGLSQFINITSCNRNELLLYQQNNTVTSINS-CINEFKKFVDRMMCKRSVIENYVHGALRNCTMPCSFYSYESEQSTSTWPTKSWQLTWLNSSYNKKLGVFNSTEFKPYHEAQRLLELGNESEAANILDNIDVLERKLLAVLINRPNFDVRKVEEKEVLSLTSLLSQTGGLFSIWIGLSMISLGEVVEMCIRCYLRVKHSRNTSIYQDDSCHTESVSC 653
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4S2L1I9 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_010139 PE=3 SV=1) HSP 1 Score: 527.324 bits (1357), Expect = 1.459e-176 Identity = 265/545 (48.62%), Postives = 364/545 (66.79%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVS-TDIPFCSSMPIFVPKRNCE--TPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHR------DPNPRHTDG 1764
REE FC++T+IRG+P I RA ++++R++W V+ L++G IC++FL RQYLE+NVIHPP+V+R +SPFP+VTVCNLRPISP G R L++ +KTPR + D + + +++DY + ++F +LESLP++ ER+ LGY +I CQ+++L GS+ A C G WR+FIHAQYLNC TF+ L T +E+++YL++ TC DCF E+KSQLSGA+I +H P++N +SIN+ PGSLTEI L + N+QK PPYGRCS P++V +YG + +YSE+ACRQ TIQNEI KCGC +IE+P+ + CS +P FV +C+ +N++C Q+T L R+ CK SV ++ +V SC++PC+F+SYE ++S STWPTK+WQL WLNS + G+ N EFQ YR L G E A LL Q N+LERNLLA+LI+RPNF++ KVEEKEVLSLTS LSQSGGLFSIW+GLTMI+L E+IE + C + R PN +DG
Sbjct: 64 REELCRFCENTTIRGLPRIVRAHSRSLRLLWSALVTILMLGCTICLLFLGRQYLEYNVIHPPRVLRHTSSPFPAVTVCNLRPISPDGVRYLKQRGWKTPRQFGMDLARFTQHFYYNVGRKEDYKMASAAISFAGFLESLPNDEERRKLGYLHEKLIIKCQITYLNGSKYVASPCDMT---GRWRKFIHAQYLNCATFEPFAELLAYTTNIELYIYLNDLTEYATCPDCFINEVKSQLSGALIVIHPADYLPDVNDKSINLKPGSLTEIRLSTVENVQKMPPYGRCSHDLPESVLLYGTDYAYSEYACRQATIQNEISAKCGCFSIEFPYHEHAGLAPCSRLPAFVNISSCDNVASATVNNTCATQLTEFLQRMLCKRSVTERFAHGIVPSCTMPCAFYSYEAEQSTSTWPTKVWQLTWLNSSSIRRLGIFNGPEFQIYREAQALLAQGDESAAARLLEQANLLERNLLAVLINRPNFDVRKVEEKEVLSLTSLLSQSGGLFSIWMGLTMIALGEIIEFFMRCFVKAKALRRNRNTLRPNSLPSDG 605
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: G7Y960 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CLF_103153 PE=3 SV=1) HSP 1 Score: 526.939 bits (1356), Expect = 3.000e-176 Identity = 263/545 (48.26%), Postives = 364/545 (66.79%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPF-VSTDIPFCSSMPIFVPKRNCE--TPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHR------DPNPRHTDG 1764
REE FC++T+IRG+P I RA ++++R++W V+ L++G C++FL RQYLE+NVIHPP+V+R +SPFP+VTVCNLRPISP G R L++ +KTPR + D + + +++DY + ++F +LESLP++ ER+ LGY +I CQ+++L GS+ A C G WR+FIHAQYLNC TF+ L+ T +E+++YL++ TC DCF+ E+KSQLSGA+I +H P++N +SIN+ PGSLTEI L + N+QK PPYGRCS P++V +YG + +YSE+ACRQ TIQNEI KCGC +IE+P+ + CS +P FV +C+ +NS+C Q+T R+ CK SV ++ +V +C++PC+F+SYE ++S STWPTK+WQL WLNS + G+ N EFQ YR L G E A LL Q N+LERNLLA+LI+RPNF++ KVEEKEVLSLTS LSQSGGLFSIW+GLTMI+L E+IE + C + R PN +DG
Sbjct: 64 REELCRFCENTTIRGLPRIVRAHSRSLRLLWSALVTILMLGCTTCLLFLGRQYLEYNVIHPPRVLRHTSSPFPAVTVCNLRPISPDGVRYLKQRGWKTPRQFGMDLARFTQHFYYNAGRKEDYKMASAAISFAGFLESLPNDEERRKLGYLHEKLIIKCQITYLNGSKYVASPCDMT---GRWRKFIHAQYLNCATFEPFAELRAYTTNIELYIYLNDLTEYATCPDCFNNEVKSQLSGALIVIHPADYLPDVNDKSINLKPGSLTEIRLSTVENVQKMPPYGRCSHDLPESVPLYGTDYAYSEYACRQATIQNEISAKCGCFSIEFPYNEHAGLEPCSRLPAFVNISSCDNVASATVNSTCAAQLTEFAQRMLCKRSVTERFAHGIVPTCTMPCAFYSYEAEQSTSTWPTKVWQLTWLNSSSIRRLGIFNGPEFQIYREAQALLTQGNEGAAARLLEQANLLERNLLAVLINRPNFDVRKVEEKEVLSLTSLLSQSGGLFSIWMGLTMIALGEIIEFFMRCFVKAKALRRNRNTLRPNSLPSDG 605
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1a (acid-sensing ion channel 1A-like [Source:NCBI gene;Acc:103034215]) HSP 1 Score: 80.8777 bits (198), Expect = 1.209e-15 Identity = 117/529 (22.12%), Postives = 218/529 (41.21%), Query Frame = 1
Query: 172 LFCQSTSIRGIPHIFRARNKTVRV-MWL-FFVSALIIGWCICMIFLLRQYLEF-NVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQ--YLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF---DISPIL----QNNVTTLEMFLYLDEN----MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPK--RNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
+F +++ GI HIF T+R +WL FF+S++ C+C+ +L YLE+ +V +V+ A FP+VT+CNL + RV + + + A ++ Y I+ +L++++ + T NF ++ + R G+++ + +++CQ +GS C+ + + +Y C+TF + P+L + LE+ L + ++ + T F A IK Q VH+ P I+ V PG T ++ Q + PP+G C T + + Y++S ACR +++ C CR + P D P+C+ P+ + C P AL+ + + N Y C PC+ Y + S P+K ++L + +KS EK D N+L L + N +E+++ + L GG +++G ++++++E+ + L
Sbjct: 24 VFAHMSTLHGIAHIFTYDRITLRCCLWLLFFLSSVAFLVCVCVDRVLF-YLEYPHVTKVDEVVAPAMV-FPAVTLCNLNAF--RFGRVTRNDLYHAGELLALLNSRYEIRDVHLIEESVLESLKTKADFQNFKPRPFNMMEFYNRT--GHDIRDMLLSCQ---FRGSP-----CRPED-----FKVVFTRYGKCYTFNSGETGPLLISMKGGMGSGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQ-------VHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPPPWGNCKTGTLDSDFFTAYSIS----ACRIDCETRYLVENCNCRMVHMP---GDAPYCT------PELYKECAHP-------------ALDFL---VERDNDYCL-----CETPCNTTRYSKELSFVKIPSKA-SAKYLAKKFSKS-----------------------EKYIAD----------NVLVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYL 458
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544]) HSP 1 Score: 76.2554 bits (186), Expect = 3.390e-14 Identity = 112/543 (20.63%), Postives = 209/543 (38.49%), Query Frame = 1
Query: 151 NWREETILFCQSTSIRGIPHIFR-ARNKTVRVMWL---FFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCN--LRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRK-------DYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQF--IHAQYLNCHTF----DISPILQ----NNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPK--RNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
N ++ T+ F T + G+ ++F +++ R +WL F L+ W I L Y I+ ++ N FP+VT+CN L +S + L + + + S N +LK ++ + D+ Y+ P L + LG+ L + ++ C+ +G S +R F I+ +Y C+TF D +P+L LE+ L + ++ D + S +G + +H+ P I+ V PG T ++ Q L PP+G C + + Y+++ ACR +++ C CR + P ST + P+ ++C P AL+ + + + N V C PC+ Y + S+ P+K +AK F N+TE Q +G +D+ ++ N K+E+K+ + L GG +++G ++++++E+ + L
Sbjct: 26 NTKKITLAFVLRTKVHGLKYVFAPGKSRIHRFLWLLAMFVCLGLLFTWSWNRILYLMSYPAVTKIY---MVWAHNMTFPAVTLCNQNLFRVSSLTKADLYHSGYWMDIMHLNHSVNRQSLAMLKHSRHRERLMRLLDFAGYS-----PPARHKLSTTEMISRLGHQLEDMLLECR---FRGENCS------------FRNFTPIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLDIQQDEYLPVWGD---TDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCKSTPIDSEFFSTYSIT----ACRIDCETRYLLENCNCRMVHMPGTST---------VCTPEQYKDCADP-------------ALDFL------VEKDNDYCV--CQTPCNMTRYGKELSMVKIPSKASA-----KYLAKKF---NKTE----------QYIGDNILVLDIFFEA----------------LNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYL 474
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544]) HSP 1 Score: 71.2478 bits (173), Expect = 1.100e-12 Identity = 114/537 (21.23%), Postives = 206/537 (38.36%), Query Frame = 1
Query: 166 TILFCQSTSIRGIPHIFR-ARNKTVRVMWL---FFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCN--LRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAY----LESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF----DISPILQ----NNVTTLEMFLYLDEN----MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPK--RNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
T+ F T + G+ ++F +++ R +WL F L+ W I L Y I+ ++ N FP+VT+CN L +S + L + + + S N +LK ++ ++ L+F Y L + LG+ L + ++ C+ S R+ TP I+ +Y C+TF D +P+L LE+ L + ++ + +T + A IK QL H+ P N VTPG T ++ Q PP+G C + + Y+++ ACR +++ C CR + P ST + P+ ++C P AL+ + + + N V C PC+ Y + S+ P+K +AK F N+TE Q +G +D+ ++ N K+E+K+ + L GG +++G ++++++E+ + L
Sbjct: 13 TLAFVLRTKVHGLKYVFAPGKSRIHRFLWLLAMFVCLGLLFTWSWNRILYLMSYPAVTKIY---MVWAHNMTFPAVTLCNQNLFRVSSLTKADLYHSGYWMDIMHLNHSVNRQSLAMLKHSRHRE--RLMRLLDFAGYSPPARHKLSTTEMISRLGHQLEDMLLECRFRGENCSFRNF------TP-------IYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLDIQQDEYLPVWGDTDETSYEAGIKVQL-------HSQSEPPFPNELGFWVTPGFQTFVSTQEQRLQYLPPPWGDCKSTPIDSEFFSTYSIT----ACRIDCETRYLLENCNCRMVHMPGTST---------VCTPEQYKDCADP-------------ALDFL------VEKDNDYCV--CQTPCNMTRYGKELSMVKIPSKASA-----KYLAKKF---NKTE----------QYIGDNILVLDIFFEA----------------LNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYL 456
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599]) HSP 1 Score: 62.3882 bits (150), Expect = 1.837e-10 Identity = 81/401 (20.20%), Postives = 149/401 (37.16%), Query Frame = 1
Query: 541 TLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDI---SPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKT----VYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQM--TIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCC 1716
T + + +PS + ++S N+ +F+ +C S + S + +F H Y NC+TF+ S + Q + + L L N I S ++GA I VH + P + ++ PG T + ++ + + PYG C+ +Y Y V E +C Q+ + ++ CGC YP + + +CS TA C ++ + + C V+ C+ PC+ + + WP + +W+ ++ LQ + + + NV R L N+ + E ++ LS G +S+W G +++S +EV EL ++CC
Sbjct: 189 TFQYVNIMSQVPS-YIKQSDDANIEDFIFSCMFSGMPCSDSE------------YSRFHHPTYGNCYTFNSANSSKLWQASKPGRDYGLSLILRTEQNDYI-----PFLSTVAGARIMVHDQESPPFMEEGGFDMRPGFETSLGIRMLEATRMPDPYGNCTEDGSNVPVLNLYSSAYTVQVPECSCFQLAL----VEACGCGYYFYP-LPPNASYCS-----------YNNTAWAGHCYYKLYRQFISDELGC------------VDKCAQPCTTKRFAVTPGYAAWPDSSSE-KWI-------------------FNLLSLQNNYSVTTVRNDVAKLNVYFREL----------NMKTISESAATNVIWLLSNIGSQWSLWFGSSVLSWLEVGELGIDCC 513
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600]) HSP 1 Score: 56.225 bits (134), Expect = 1.618e-8 Identity = 73/338 (21.60%), Postives = 136/338 (40.24%), Query Frame = 1
Query: 712 FIHAQYLNCHTFDISP---ILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYN-VSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNC 1713
F H Y NC F+ ++Q + +E L L +++ + I + ++GAVI VH T+P ++ + V G T + ++ ++ PY C+ YN +YS AC + Q ++I+ CGC YP + +C + F R C K + + + D C PC Y+ S+S WP++ + +W+ F +L++ RI ++ ++++ NL FN + E ++ + LS GG F W+G +++ ++E IE++++C
Sbjct: 268 FFHPMYGNCFIFNWGENETVMQVSNPGVEYGLKLVLSIDQDEYI-----PFLTTIAGAVIMVHDQNTYPFLSDLGVFVKTGVETSVGIEVGQLQRQGAPYSDCTMDGTDLPITNLYNGTAYSVQACLRSCFQTKMIEMCGCGYYLYPLPPGE-KYCQNQN-FTGWRYC-------------------YYKLYEQFVEE-DMDCYTICKQPCIESEYKMSISMSDWPSQSSE-DWI-------FHILSKERKHNVSRIFNRKQ--------------DIIKLNLFF-----QEFNSMTISESPAQTIVTLLSNLGGQFGFWMGGSVLCIIEFIEIIIDC 551
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1G (sodium channel epithelial 1 gamma subunit [Source:HGNC Symbol;Acc:HGNC:10602]) HSP 1 Score: 51.6026 bits (122), Expect = 4.922e-7 Identity = 45/190 (23.68%), Postives = 76/190 (40.00%), Query Frame = 1
Query: 586 ERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISP---ILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQK-APPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPF 1143
++ LGY+ F+I+C S C P ++++ H NC TF+ L ++ L++ N + + + +GA I +H T P I I++ P + + L+ + ++QK PY C+ Y+ YS C+ Q E+IK CGC E P
Sbjct: 238 DKDKLGYSADEFIIDCLFS--------GTVCD---PSTSFKKLQHPILGNCFTFNDGSDGKSLDIASAGIDYGLHMVLNTRQDNSLPYL-----AMGAGAKIGIHLQNTTPFIEAVGIDIPPAMESSLGLR-VNDVQKLGDPYSDCTMDGSDIDVKSLYDSPYSVQTCQNSCFQWEMIKSCGCANYEQPL 410
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2]) HSP 1 Score: 77.7962 bits (190), Expect = 4.134e-15 Identity = 105/542 (19.37%), Postives = 204/542 (37.64%), Query Frame = 1
Query: 160 EETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLR---------PISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAG---TPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMF----------LYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTV----YMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVST-DIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
E+ F Q T+ G + R+ W+ F A + ++ L+ QY + Q+ FP VT+CN+ + K ++++ + +PRN + N + L + K + Y E + S + L + +++C + V C+ T W Q + + NC+ F+ + +N ++++ L L N+ N + E ++++G + + G P + I + PG T I + L ++ P+ S ++ + +GYN++YS AC+ + I++CGC P + +IP C+ + NS+ I + A + + + C CS S++ S + WP A+SF + T++ + R+ L K+ Y N N+ + + + V+E + S LS GG +W+G++ ++ E+IEL+
Sbjct: 13 EQINQFLQETTAHGFGRLGATAGSKWRLYWVMFCLAAYCVFVWQLVGLVNQYNSKPIKTRTQLKHAQKLDFPVVTICNMNVLRASRLPPKLRTKFDQIINNTNKTSPRNSSNSRNAFVDPQDLSFEETKKFEILHAVTAHDDYRELV-------SAAHQLEDILLSCNFN--------GVNCRNSKDPTIPTYWTQTWNDNFGNCYMFN--SVKTHNGEKVDLYSSSVPGESNGLTLQLNLEQNE-----YLEGITEVAGMKVTISDQGVLPFPGQQGIRIMPGQSTGIQMTK-LQTRRIDPFKNRSCESSNEMSDKNLFFGYNMTYSIMACKYSCLNARKIERCGCTNYNTPEMQKRNIPLCNRL---------------NSTIIDCLNKAYDTFE---------DGSCDRECPPSCSEVSFDLTVSSARWP-------------ARSFEV---TKYAYFLRVRVLNKIASSSSK----YFVN--SENIAQVHVYYGELDYLLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELV 485
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO31696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX71]) HSP 1 Score: 74.7146 bits (182), Expect = 2.645e-14 Identity = 88/384 (22.92%), Postives = 153/384 (39.84%), Query Frame = 1
Query: 592 KSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGT-WRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNS-NTCIDCFHAEIKSQL---SGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKT------VYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSF-GMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLV 1707
K +G+ + V C V C+A G W F H ++ NC F+ S I N T + +Y +N ++ E Q+ +GA+I V G P R V PG T+I L+ ++I++ P+ S T + ++ +N SYS+ AC + + +C C +EY F + + C+T + C+ ++ L+R + S +C C +Y S + WP++ +Q NS + F G+ N Y R ++ N LE N+ ++ + +EE L +FLS GG +W+G+++++ EV+EL +
Sbjct: 75 KPMGHQFDDMVYKCTWR--------GVDCKANYTQGKYWTSFWHYRFGNCFVFNPS-IGWNRNTRSRLHIYRTGPLNGLQLQLNIQQEEYIDQITKRAGAMIQVFPFGQMPFPEERGTLVAPGFSTDIGLEK-MDIKRVDPHNNGSCVTDEASINTENIFKQKFNTSYSKTACVLSCLAYHQMHECKC--MEYRFPTDSV--------------CDTLNSTIVECLAKVKFKLSRNELGCST----------ACGPACREEAYRLTSSFAVWPSQRYQ----NSIIDNLFDGIFN------YSRS---------------WFRDNYLEVNIFFKELN------YFIEESVAYELVNFLSDIGGQLGLWVGVSVMTGAEVVELAL 391
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO34318 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPS2]) HSP 1 Score: 67.0106 bits (162), Expect = 8.781e-12 Identity = 71/278 (25.54%), Postives = 107/278 (38.49%), Query Frame = 1
Query: 598 LGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGT-WRQFIHAQYLNCHTFDISPILQNN------VTTLEMF----LYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCS------PKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPT 1380
LG+ + V C +GS C+A G W +F H +Y NC F+ P++ N +T L L L+ N+ + ID S +GAVI V G P I+V+PG T I L + I + +G S K + +Y YN +YS+ AC + K C C +P + C+T C++++ L K+ +N CS PC+ +Y+T S S WP
Sbjct: 25 LGHQFDSLVRKCS---WRGSD-----CRANATTGRYWGRFWHNKYGNCFVFN--PLIGWNGKKRRALTALRAGPNYGLTLELNVEQDEYIDGL-----STKAGAVIQVSPVGYMPFPEEEGIDVSPGFSTSIALTKV-KISRVDAFGNRSCVNEITEKDRENLYHVKYNATYSKTACLNFCLAYNQRKTCNCMEYRFPVEEEAV--------------CDTMNKTTVECLRRVREML-----KMKKLN-----CTAECSAPCNQETYKTTSSFSMWPA 262
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF92]) HSP 1 Score: 65.4698 bits (158), Expect = 2.785e-11 Identity = 64/271 (23.62%), Postives = 111/271 (40.96%), Query Frame = 1
Query: 922 RSINVTPG--SLTEITLQNILNIQKAPPYGRCS-----PKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNK-DVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNS-RVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLV 1707
+ I+V+PG + T I + NIL +A P+ S P+ +Y YNVSYS C + ++ + CGC +EY F P N + + I + R K+ + Q NK E C PC+ ++ S + WPT ++ +L+ + K F + + + Y ++LQ + Y+ N +EE L +F+S GG +W+G++ ++ E++ELL+
Sbjct: 7 KGISVSPGFSTTTGIRMTNIL---RADPFNNKSCLSSDDIDPENLYRKRYNVSYSRTTCMDSCLAHKQVDMCGC--LEYRF----------------------PNIDNRTVCDILDIDVIRCLNKVQSLYQDNKLGCSEKCRPPCNEEVFKLSISSARWPTDDYEAHFLDELKEDKGFVLPANADARAY--FVKLQ----------IFYE----------------ELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLI 222
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFR0]) HSP 1 Score: 63.929 bits (154), Expect = 1.726e-10 Identity = 60/249 (24.10%), Postives = 102/249 (40.96%), Query Frame = 1
Query: 703 WRQFIHAQYLNCHTFDIS--------PILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCS-----PKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNK-DVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLN 1407
W +F H +Y NC+ F+ PIL++N L L+ N + + E +G + + T G P+ + I+V+PG T ++ + NI +A P+ S P+ +Y YNVSYS C + ++ + CGC +EY F P N + + I + R K+ + Q NK + C PC+ ++ S + WPT ++ +L+
Sbjct: 310 WSRFWHYRYGNCYVFNSGKDWQGEPKPILRSNKPGPASGLTLELNAEQHEYVGQLSHE-----AGMRVLISTQGEMPSPLEKGISVSPGFSTTTGIR-MTNILRADPFNNKSCLSSDDIDPENLYKKRYNVSYSRTTCMDSCLAHKQLDMCGC--LEYRF----------------------PNIDNRTVCDILDIDVIRCLNKVQSLYQDNKLGCSDKCRPPCNEEVFKLSISSARWPTDDYEAHFLD 528
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: asic1a (acid-sensing ion channel 1 [Source:NCBI gene;Acc:101159102]) HSP 1 Score: 76.6406 bits (187), Expect = 2.112e-14 Identity = 106/527 (20.11%), Postives = 204/527 (38.71%), Query Frame = 1
Query: 172 LFCQSTSIRGIPHIFRARNKTV-RVMWLF-FVSALIIGWCICMIFLLRQYLEFNVIHPPQVIR--DANSP---FPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQ--YLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF----DISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQL-SGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPK--RNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
+F S+++ GI HIF + R +WL F+ +L + +C + + YLE+ P V R + +P FP++T CNL + RV + + + A ++ Y I+ +L++++ + NF ++ ++R G+++ + +++C +C+ G + + +Y C+TF D P L + L L ++ + + + ++ +G + +H+ P+I+ V PG T ++ Q I PP+G C TP + SYS ACR ++ C CR + P D P+CS P+ + C P + + Q + D C PC+ Y + S P+K ++L + KS ++ N+L L I N +E+K+ + L GG +++G ++++++E+ + L
Sbjct: 20 VFAHSSTLHGIAHIFTYERLCIKRCLWLLVFLCSLTLLLYVC-VDRIHYYLEY-----PHVTRLDEVATPIMTFPAITFCNLNAF--RFSRVTRNDLYHAGELLALLNHRYEIRDVHLVEESVLESLKVKADFHNFKPRPFNMREFYDRT--GHDIKDMLLSCHFH--------GTECRPGD-----FKVVFTRYGKCYTFNAGGDGRPPLITTKGGMGNGLELMLDIQQDEYLPVWGDTDETSFEAGVKVQIHSQDEPPSIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWGDCK-VTPMDSDFFD---SYSITACRVDCETRYLVDNCNCRMVYMP---GDAPYCS------PELYKECADPA--------------------LDFLVQRDNDFC-VCETPCNMTRYNKELSFVKIPSKA-SAKYLAKKYNKS---------------------------------EQYIKDNILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTILEIFDYL 455
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000031246.1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:101155423]) HSP 1 Score: 72.7886 bits (177), Expect = 3.900e-13 Identity = 112/537 (20.86%), Postives = 205/537 (38.18%), Query Frame = 1
Query: 172 LFCQSTSIRGIPHIFRARNKTV-RVMW-LFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQ--YLLKKN------KRKDYTTYTGTLNFPAYLESLPSNFERKSL----GYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF----DISPIL----QNNVTTLEMFLYLDEN----MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
+F +++ GI H+F + R +W LFF+ ++ + +C + ++ Y E+ + + + FP++T CNL S + RV + + + A + Y I+ +L+++N +R D+ +Y P +F + G+++ + +++C +G++ SA + I +Y C+TF D P++ LE+ L + ++ + T F A IK Q +HT P I+ V PG T ++ Q PP+G C TP + SYS ACR +++ C CR + P D P+CS + C P + + + + D C PC+ Y + S P+K +AK F N+TE + N+L L I N +E+K+ L L GG +++G ++++++E+ + L
Sbjct: 20 VFATRSTLHGISHMFTYERMCLKRTLWILFFMLSVGVLVMVC-VDRVQFYFEYPHVTKLDEVAASMIVFPAITFCNLN--SFRFSRVTRNDLYHAGELLALLNGRYEIRDPHLVEENVLQVLRERADFESYK------------PRSFNMREFYDRTGHDIKDMLLSCS---YRGTECSAENFKV----------IFTRYGKCYTFNSGKDGQPLMVTMKGGTGNGLELMLDIQQDEYLPVWGETDETSFEAGIKVQ-------IHTQEEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCK-STPMDSDFFN---SYSITACRIDCETRYLVENCNCRMVHMP---GDAPYCSPEQY----KECADPA--------------------LDFLVERDNDYC-VCETPCNLTRYGKELSFVKIPSKASA-----KYLAKKF---NKTE--------------------------QYIADNILVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTVLELFDYL 455
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000021925.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951]) HSP 1 Score: 64.6994 bits (156), Expect = 1.753e-10 Identity = 104/527 (19.73%), Postives = 198/527 (37.57%), Query Frame = 1
Query: 175 FCQSTSIRGIPHIFRARNKTVR-VMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQ--YLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTF----DISPILQ----NNVTTLEMFLYLDEN----MNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPK--RNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELL 1704
F +++ G+ HIF + T R +W + + + + YLE+ + + N FP+VT CNL + ++ + + + A +N++ I +L + NF L ++ + R G+++S ++ C +G A+ I+ +Y C+TF D +P+L LE+ L + ++ + T + A IK Q +H+ P I+ V PG T ++ Q L PP+G C + + Y+++ ACR +++ C CR + P ST + P ++C P AL+ + + + N V C PC+ Y + S+ P+K +AK F N+TE Q +G +D+ ++ N K+E+K+ + L GG +++G ++++++E+ + L
Sbjct: 20 FANISTLHGMSHIFAYGHMTFRRFLWTLSFLGSLSLLMLVCMDRVVYYLEYPHVTKLDEVAATNLTFPAVTFCNLNEF--RFSKITRNDLYHVGELLALLNNDHQIANPHLAEPEVLAALKDKANFNNFKPKLFNMTDFYNRT--GHDISEMLLQCT---FRGEDCYAMNFTT----------IYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLDIQQDEYLPVWGETDETSYEAGIKVQ-------IHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCKSTPIDSEFFSTYSIT----ACRIDCETRYLLENCNCRMVHMPGTST---------VCTPDQYKDCADP-------------ALDFL------VEKDNNYCV--CETPCNMTRYGKELSMVKIPSKASA-----KYLAKKF---NKTE----------QYIGDNILVLDIFFEA----------------LNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYL 454
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000064187.1 (SMESG000064187.1) HSP 1 Score: 1224.54 bits (3167), Expect = 0.000e+0 Identity = 588/588 (100.00%), Postives = 588/588 (100.00%), Query Frame = 1
Query: 34 MTHNEYETKFGDTWYYPTRNIQIPTDEYDVISLKYQGCSNWREETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHRDPNPRHTDGIRCPHERNFKS 1797
MTHNEYETKFGDTWYYPTRNIQIPTDEYDVISLKYQGCSNWREETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHRDPNPRHTDGIRCPHERNFKS
Sbjct: 1 MTHNEYETKFGDTWYYPTRNIQIPTDEYDVISLKYQGCSNWREETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHRDPNPRHTDGIRCPHERNFKS 588
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000028687.1 (SMESG000028687.1) HSP 1 Score: 508.449 bits (1308), Expect = 4.897e-174 Identity = 240/519 (46.24%), Postives = 351/519 (67.63%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNC 1713
+EE + FC++T+IRG+P I ++++K +R MW+ L+ G+ +C IFLL+QY ++VIHPP+++ ++ +PFPS TVCNLRP++ + + + + KTPR +A++ NNY I+Y KN Y + + YLES+P N LG+ + +I+C+++++ GS+ + C G WR+ IHAQY+NC+ FD+ L N TLEMFLYLDE++N TCIDCF +++KSQLSGA+I +H TFPN N IN+ PG+LTEI L+ I N K PPYGRCS KTPK + ++G +YSE C+ ITIQ ++ C C AIEYPF + + FCS++P F + +C + C ++ + +I CK YN D+V SC LPCSF+SYETDRS STWPTK WQL+W++++ AK +L++ E YR ++LQ+ G EA+ +L + N +E+ +LA++I+RPN+N+H VEEKEVLSLTSFLSQ+GGLFSIW+G+T+ S+VE+ E+ NC
Sbjct: 43 KEEFLRFCENTTIRGVPKIIKSKHKPLRYMWMTCFILLLSGFSVCFIFLLKQYFAYDVIHPPRILTNSQAPFPSFTVCNLRPLARNIDTIFKLKNLKTPREFAKNVNNYAIKYFYNKNNLTLYGHASSIMLMGGYLESVP-NKSYVELGHKKQDLIIHCRVTYMIGSKPHSKDCDE---LGKWRRIIHAQYVNCYMFDLIESLSNATNTLEMFLYLDESINQATCIDCFSSDVKSQLSGALILIHRSNTFPNFNRDMINLQPGTLTEIKLKTIHNRHKLPPYGRCSNKTPKWIKVFGELYAYSEDLCKLITIQGDLNHFCNCNAIEYPFNYSSLKFCSALPSFSQRVSCNNRLN-DRKCETELKNTVKQISCKAKACLIYNNDIVPSCKLPCSFYSYETDRSTSTWPTKSWQLQWISTKAAKP--LLDKQELDNYRYAVKLQEKGNYSEALKILNKENTMEQKILAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLFSIWIGMTLFSIVEIFEMFANC 554
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000045054.1 (SMESG000045054.1) HSP 1 Score: 503.056 bits (1294), Expect = 3.387e-171 Identity = 238/518 (45.95%), Postives = 355/518 (68.53%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPT-AINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLV 1707
++E + +C +++IRG+P I ++RN+ +R++W+ +L++G+ C+ L RQ+ E+NVIHPP+V+ DA S FPSVT+CN RP+S +G++++++ +++ P + N + I+ K +R DY T + +YLESLP+ +RKSLG+ L NFVI CQ+++L GS+ A C G+W +IHA Y+NC+T+++ + T+E++LYL+E+MN C DC +IKSQ+SGAV+A+ P TF NIN + I++ PG+LTEI L+ NI+ PPYGRCS TPK + M+ YSE C+Q TIQ + ++C C AIEYP+ ++ +PFC F+ K C +P+ + NS+CIK + L ++CK + +Y +D +E+C++PCSF SYE+DRS S WP K +Q+ ++ V K ++++ EF+PYR+I EL G KEA LL TNVLERNL+A+L+ +PNFNLHKVEEK VLSLTSFLSQ GGL SIW+GLTMIS+VE+ EL++
Sbjct: 61 KDEFLHYCYNSTIRGVPRIAKSRNRPMRILWIISFVSLLLGFSSCVYLLGRQFSEYNVIHPPRVLTDAESDFPSVTICNSRPLSLEGKKIIKDKNWRKPNEFTSIINKWAIKEYYNKGRRNDYFLTTPAMQLSSYLESLPTEKDRKSLGHQLKNFVIYCQITYLNGSKGIAYPCDR---IGSWTDYIHAFYINCYTYNLKVQYRKMTKTMEVYLYLEEDMNEINCPDCMRYDIKSQISGAVLAIDRPETFSNINEKGISLMPGTLTEIRLKTFENIRITPPYGRCSENTPKKLKMFDKEFVYSEKGCKQATIQIDFERECKCVAIEYPYNTSRLPFCGQGSAFINKNECSSPSKSENSTCIKILDTILENMRCKEQITQRYYRDYIENCTMPCSFLSYESDRSTSMWPAKSFQIALIDKGVFKENNIISKPEFEPYRKIKELIGKGMNKEAAKLLDNTNVLERNLVAVLLIKPNFNLHKVEEKAVLSLTSFLSQIGGLCSIWIGLTMISIVEMFELIM 575
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000069611.1 (SMESG000069611.1) HSP 1 Score: 486.878 bits (1252), Expect = 1.427e-165 Identity = 233/534 (43.63%), Postives = 350/534 (65.54%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPT--AINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLV--------NCCGGGR 1728
+ E + FC++T+IRG+P I NK+ +++W+ F L G IC+ FL+RQ++E++VIHPP+V++++ SPFPS TVCN RP+S + + + PR +A +N +YL + + Y+ T + + YLES+P + LG++ +FVI+C ++F GS+ CQ G W+ HAQ++NC +++I VTT+E++LYL+E N + CIDCF + +KSQLSGA++ +H +FPNIN +IN+ PG+LTE+ L+ N+ K PYGRC P TP + M SY+E C++ TIQ EI KC C AIEYP V+ ++ FCS++P F+ +CET + C +++ +L R++CK SV Y+ D++++C LPC ++SYE+DRS+STWPTK WQL WLNS ++ + ++ E +PY+ E K GKE +A+++L + ++LE L+A++I+RPN NLH+VEEKEVLSLTSFLSQ GGLFSIW+GLT+IS+VE+IELL+ CC R
Sbjct: 52 KNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEY-HNMLGHDYYDFVIDCLITFRNGSKHHVDLCQN---IGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPTFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNS--SRGSNVRSKKELKPYKIAAEYFKEGKEDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRR 579
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000078360.1 (SMESG000078360.1) HSP 1 Score: 487.649 bits (1254), Expect = 4.954e-165 Identity = 235/532 (44.17%), Postives = 359/532 (67.48%), Query Frame = 1
Query: 157 REETILFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNY-GIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNC---ETPTAINS-SCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNCCGGGRPHR 1737
+ E I FCQ+T++RGIP I +A+++ +R++W+ FV L IG + M+FL +QYLE+NVIHPP ++ D PFPS+++CNLRP+S G L++N+++ PR + + N Y ++ ++ + YT +T ++ YLES+P + K LG++L VI+C + + GS+ +C + G W + HA Y+NCH+ I P L+N++ ++ M++YLDE + +N C DCF E+KSQLSGA++ VHT T+P+IN ++N+ PG+LTE L+ ILN KAPPYGRCS T + ++ +N YSE AC+ TIQ EI C C AIEYP + +PFCS++P F+ ++C +T +N+ +C ++ N + CK ++ +Y DVV C+LPCSF+SY +DRS STWPTK +QL +NS A+ + N+ +F+PY ++I + G E EA+++L + N+LERNLL ++I+RPN +H VEEKEVLSLTS+LSQ+GGLFSI++GL++IS+VE +ELL++C + R
Sbjct: 77 KHELIAFCQNTTMRGIPRIIKAQSRNLRILWITFVVILFIGLLLSMLFLTKQYLEYNVIHPPVILPDQEPPFPSISLCNLRPLSRFGLEFLKKNNWRNPREFGNNLNVYVANKWYYNQSTKHYYTQFTTAISMNGYLESVPFDVLDK-LGHSLDELVIHCLVIYNVGSKSEIQKCGS---LGHWTKTTHALYINCHSLTIYPELRNHIKSVIMYIYLDEILKTNLCADCFMQELKSQLSGALVVVHTSDTYPDINQEAVNLQPGTLTEFNLKFILNKNKAPPYGRCSKYTETHIKLHNHNYIYSEHACQLTTIQREINDICRCNAIEYPIFNLSLPFCSALPSFISHKDCISSKTKKVLNNKTCDMEILKVFNNLGCKNNITIKYRSDVVAKCTLPCSFYSYASDRSTSTWPTKSFQLNLINSEKARE--LRNKEDFKPYLKLINISNEGHETEALEMLEKLNILERNLLGIMINRPNNKVHVVEEKEVLSLTSYLSQTGGLFSIFIGLSIISVVEFLELLIHCVEAFKVTR 602 The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035411 ID=SMED30035411|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1872bpback to top protein sequence of SMED30035411-orf-1 >SMED30035411-orf-1 ID=SMED30035411-orf-1|Name=SMED30035411-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=589bp MTHNEYETKFGDTWYYPTRNIQIPTDEYDVISLKYQGCSNWREETILFCQback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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