Tyrosine-kinase Fes Fps-like isoform X5

Overview


Name	Tyrosine-kinase Fes Fps-like isoform X5
Smed ID	SMED30035381
Length (bp)	3201

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Tyrosine-kinase Fes Fps-like isoform X5 (SMED30035381) t-SNE clustered cells

Violin plots show distribution of expression levels for Tyrosine-kinase Fes Fps-like isoform X5 (SMED30035381) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tyrosine-kinase Fes Fps-like isoform X5 (SMED30035381) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tyrosine-kinase Fes Fps-like isoform X5 (SMED30035381) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30035381

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30035381	SMESG000047737.1	dd_Smed_v4_14652_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30035381	SMESG000047737.1	dd_Smed_v6_14652_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
enteric muscle cell	SMED30035381	SMESG000047737.1	dd_Smed_v4_14652_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
Match: STAC2 (SH3 and cysteine rich domain 2 [Source:HGNC Symbol;Acc:HGNC:23990])

HSP 1 Score: 83.9593 bits (206), Expect = 3.280e-16
Identity = 42/116 (36.21%), Postives = 67/116 (57.76%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTG-SQDGDQILIRTKINTTFWCPIDCVTKV 3134
            YVALY F  ++ ++L L+ G ++  +D S+ DWW GK   + G+FPAN+VQ +  GE+VWR  +  S  +  Q  + L +NQI V  G S+D D  +  +        P+D +T++
Sbjct:  297 YVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFS-GNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 411

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
Match: STAC3 (SH3 and cysteine rich domain 3 [Source:HGNC Symbol;Acc:HGNC:28423])

HSP 1 Score: 78.1814 bits (191), Expect = 7.458e-16
Identity = 40/115 (34.78%), Postives = 63/115 (54.78%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T      + P D + ++
Sbjct:   66 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLF-PTDFLEEI 178

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
Match: STAC3 (SH3 and cysteine rich domain 3 [Source:HGNC Symbol;Acc:HGNC:28423])

HSP 1 Score: 77.7962 bits (190), Expect = 2.047e-14
Identity = 40/115 (34.78%), Postives = 63/115 (54.78%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T      + P D + ++
Sbjct:  252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLF-PTDFLEEI 364

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
Match: STAC3 (SH3 and cysteine rich domain 3 [Source:HGNC Symbol;Acc:HGNC:28423])

HSP 1 Score: 76.6406 bits (187), Expect = 3.227e-14
Identity = 38/99 (38.38%), Postives = 57/99 (57.58%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRT 3086
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T
Sbjct:  213 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYT 310

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
Match: STAC (SH3 and cysteine rich domain [Source:HGNC Symbol;Acc:HGNC:11353])

HSP 1 Score: 75.8702 bits (185), Expect = 6.281e-14
Identity = 37/98 (37.76%), Postives = 59/98 (60.20%), Query Frame = 3

Query: 2775 LRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQT-GSQDG 3065
            L+ N YVALY F  ++ ++L +R G  ++ ++ S+ DWW GK   + G+FPAN+VQ + Q E ++R +R   +    Q  + L +NQI V +   QDG
Sbjct:  224 LQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTF-IGCKEQGQITLKENQICVSSEEEQDG 320

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 54.6842 bits (130), Expect = 3.822e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 3

Query: 2787 LYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            LY  +YDF   +  +L L  G  +  ++ +D +WW G+CNG+ G FPANYV+
Sbjct:  628 LYTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 678

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 54.6842 bits (130), Expect = 3.918e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 3

Query: 2787 LYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            LY  +YDF   +  +L L  G  +  ++ +D +WW G+CNG+ G FPANYV+
Sbjct:  626 LYTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 676

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 54.299 bits (129), Expect = 4.993e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 3

Query: 2787 LYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            LY  +YDF   +  +L L  G  +  ++ +D +WW G+CNG+ G FPANYV+
Sbjct:  888 LYTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 938

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 54.299 bits (129), Expect = 5.033e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 3

Query: 2787 LYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            LY  +YDF   +  +L L  G  +  ++ +D +WW G+CNG+ G FPANYV+
Sbjct:  886 LYTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 936

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 53.5286 bits (127), Expect = 8.294e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 3

Query: 2787 LYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            LY  +YDF   +  +L L  G  +  ++ +D +WW G+CNG+ G FPANYV+
Sbjct:  433 LYTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 483

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0344200)

HSP 1 Score: 106.301 bits (264), Expect = 2.416e-23
Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 3

Query:  288 ASYHGAI----HQKMQESMNIIDNVN-QLLKEVSETYETFCDSLSLICTKFSKSL--TSSNYSSDFLDL--------------WNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILA---------RDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQ----------LQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLK-RDKGSKNQSILKNIKKESFRPASSPLQ 1523
            ASY+G +    H  + E+    +NVN +L+K VS+    F ++LS +  + + +L    SNY     +L              W   LQ   +++Q  ++        V  P+   S H+  Q  K++  R S E ++    + + +   DY   +   R+      +   ++AHN YV QL A+N M + YH+  LP  + ELE I  +++ I   SL   +   A K        + + +   ++SP   ++NFVR L          R  F  P  +  E            R++++ D+ +    +     L +E  EL   I Q  D I  L   +T G    + + K+ EL +D+  K+ ++R  Q+ +A + AQ              + +KFS           MK  W KA  SLK    GS  Q+  +N    +   AS PL+
Sbjct:    2 ASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSD----FSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIE-GQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATA-----PSMKTKWLKAFKSLKPAGSGSAQQADRRNGASST---ASEPLR 441

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0344202)

HSP 1 Score: 106.686 bits (265), Expect = 5.718e-23
Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 3

Query:  288 ASYHGAI----HQKMQESMNIIDNVN-QLLKEVSETYETFCDSLSLICTKFSKSL--TSSNYSSDFLDL--------------WNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILA---------RDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQ----------LQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLK-RDKGSKNQSILKNIKKESFRPASSPLQ 1523
            ASY+G +    H  + E+    +NVN +L+K VS+    F ++LS +  + + +L    SNY     +L              W   LQ   +++Q  ++        V  P+   S H+  Q  K++  R S E ++    + + +   DY   +   R+      +   ++AHN YV QL A+N M + YH+  LP  + ELE I  +++ I   SL   +   A K        + + +   ++SP   ++NFVR L          R  F  P  +  E            R++++ D+ +    +     L +E  EL   I Q  D I  L   +T G    + + K+ EL +D+  K+ ++R  Q+ +A + AQ              + +KFS           MK  W KA  SLK    GS  Q+  +N    +   AS PL+
Sbjct:  262 ASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSD----FSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIE-GQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPS-----MKTKWLKAFKSLKPAGSGSAQQADRRNGASST---ASEPLR 701

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0475071)

HSP 1 Score: 106.301 bits (264), Expect = 6.659e-23
Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 3

Query:  288 ASYHGAI----HQKMQESMNIIDNVN-QLLKEVSETYETFCDSLSLICTKFSKSL--TSSNYSSDFLDL--------------WNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILA---------RDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQ----------LQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLK-RDKGSKNQSILKNIKKESFRPASSPLQ 1523
            ASY+G +    H  + E+    +NVN +L+K VS+    F ++LS +  + + +L    SNY     +L              W   LQ   +++Q  ++        V  P+   S H+  Q  K++  R S E ++    + + +   DY   +   R+      +   ++AHN YV QL A+N M + YH+  LP  + ELE I  +++ I   SL   +   A K        + + +   ++SP   ++NFVR L          R  F  P  +  E            R++++ D+ +    +     L +E  EL   I Q  D I  L   +T G    + + K+ EL +D+  K+ ++R  Q+ +A + AQ              + +KFS           MK  W KA  SLK    GS  Q+  +N    +   AS PL+
Sbjct:  474 ASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSD----FSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIE-GQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPS-----MKTKWLKAFKSLKPAGSGSAQQADRRNGASST---ASEPLR 913

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0330007)

HSP 1 Score: 105.916 bits (263), Expect = 7.255e-23
Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 3

Query:  288 ASYHGAI----HQKMQESMNIIDNVN-QLLKEVSETYETFCDSLSLICTKFSKSL--TSSNYSSDFLDL--------------WNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILA---------RDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQ----------LQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLK-RDKGSKNQSILKNIKKESFRPASSPLQ 1523
            ASY+G +    H  + E+    +NVN +L+K VS+    F ++LS +  + + +L    SNY     +L              W   LQ   +++Q  ++        V  P+   S H+  Q  K++  R S E ++    + + +   DY   +   R+      +   ++AHN YV QL A+N M + YH+  LP  + ELE I  +++ I   SL   +   A K        + + +   ++SP   ++NFVR L          R  F  P  +  E            R++++ D+ +    +     L +E  EL   I Q  D I  L   +T G    + + K+ EL +D+  K+ ++R  Q+ +A + AQ              + +KFS           MK  W KA  SLK    GS  Q+  +N    +   AS PL+
Sbjct:  262 ASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSD----FSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIE-GQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPS-----MKTKWLKAFKSLKPAGSGSAQQADRRNGASST---ASEPLR 701

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0344206)

HSP 1 Score: 105.916 bits (263), Expect = 7.802e-23
Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 3

Query:  288 ASYHGAI----HQKMQESMNIIDNVN-QLLKEVSETYETFCDSLSLICTKFSKSL--TSSNYSSDFLDL--------------WNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILA---------RDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQ----------LQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLK-RDKGSKNQSILKNIKKESFRPASSPLQ 1523
            ASY+G +    H  + E+    +NVN +L+K VS+    F ++LS +  + + +L    SNY     +L              W   LQ   +++Q  ++        V  P+   S H+  Q  K++  R S E ++    + + +   DY   +   R+      +   ++AHN YV QL A+N M + YH+  LP  + ELE I  +++ I   SL   +   A K        + + +   ++SP   ++NFVR L          R  F  P  +  E            R++++ D+ +    +     L +E  EL   I Q  D I  L   +T G    + + K+ EL +D+  K+ ++R  Q+ +A + AQ              + +KFS           MK  W KA  SLK    GS  Q+  +N    +   AS PL+
Sbjct:  262 ASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSD----FSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIE-GQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPS-----MKTKWLKAFKSLKPAGSGSAQQADRRNGASST---ASEPLR 701

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Zebrafish
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 68.9366 bits (167), Expect = 7.499e-12
Identity = 36/112 (32.14%), Postives = 60/112 (53.57%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCV 3125
            Y+ALY F   +KD+L+   G +++ +D S+ +WW GK   K GY P  Y+  +  GE V++V R   V +     + L K+QI+V+ G +    + + T     F+ P D +
Sbjct:  222 YMALYRFKAIEKDDLDFHPGDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSF-VGNREMGQITLKKDQIVVKKGEEVNGYLKVSTGRKLGFF-PADLL 331

[Close]

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCV 3125
            Y+ALY F   +KD+L+   G +++ +D S+ +WW GK   K GY P  Y+  +  GE V++V R   V +     + L K+QI+V+ G +    + + T     F+ P D +
Sbjct:  222 YMALYRFKAIEKDDLDFHPGDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSF-VGNREMGQITLKKDQIVVKKGEEVNGYLKVSTGRKLGFF-PADLL 331

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Zebrafish
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 68.9366 bits (167), Expect = 7.571e-12
Identity = 36/110 (32.73%), Postives = 59/110 (53.64%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPID 3119
            Y+ALY F   +KD+L+   G +++ +D S+ +WW GK   K GY P  Y+  +  GE V++V R   V +     + L K+QI+V+ G +    + + T     F+ P D
Sbjct:  220 YMALYRFKAIEKDDLDFHPGDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSF-VGNREMGQITLKKDQIVVKKGEEVNGYLKVSTGRKLGFF-PAD 327

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Zebrafish
Match: grap2a (GRB2 related adaptor protein 2a [Source:ZFIN;Acc:ZDB-GENE-050417-275])

HSP 1 Score: 57.7658 bits (138), Expect = 2.056e-8
Identity = 23/51 (45.10%), Postives = 31/51 (60.78%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAI 2948
            A+YDF   + DEL   +G  +  +D SDA WW G+  G+ G FPANY + I
Sbjct:  234 AIYDFTAEEDDELGFNSGDIIEVLDRSDASWWKGRLRGRSGLFPANYTEQI 284

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Zebrafish
Match: stac (SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-GENE-131121-459])

HSP 1 Score: 57.3806 bits (137), Expect = 5.254e-8
Identity = 32/105 (30.48%), Postives = 53/105 (50.48%), Query Frame = 3

Query: 2730 EENISKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILV 3044
            EE++S++  K+    L  N YVAL+ F  +   +L +R G ++   D S+ DWW G    + G+FPA +   +   + V+R  R   +    Q  + L + QI V
Sbjct:  245 EESLSERELKRDPLLL--NTYVALFGFTAQDNQDLEMRPGDRIVLADDSNDDWWKGVIEDRIGFFPAAFAHQVTSSDRVFRCNRTF-IGCKEQGQITLKEGQICV 346

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:493233])

HSP 1 Score: 78.1814 bits (191), Expect = 1.251e-14
Identity = 40/120 (33.33%), Postives = 69/120 (57.50%), Query Frame = 3

Query: 2775 LRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            ++ + +VALY F   +KD+L+ +AG +++ ID S+ +WW GK   K GYFPAN++  +   E V++V R   V +     + L K+QI+VQ G +    I + T      + P+D + ++
Sbjct:  229 MQSHYFVALYRFKALEKDDLDFQAGERITVIDDSNEEWWRGKVGEKAGYFPANFIIRVRAAERVYKVTRSF-VGNREIGQITLKKDQIVVQKGDEVNGYIKVSTGRKVGLF-PLDFLQEI 346

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:493233])

HSP 1 Score: 77.411 bits (189), Expect = 2.109e-14
Identity = 40/120 (33.33%), Postives = 69/120 (57.50%), Query Frame = 3

Query: 2775 LRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            ++ + +VALY F   +KD+L+ +AG +++ ID S+ +WW GK   K GYFPAN++  +   E V++V R   V +     + L K+QI+VQ G +    I + T      + P+D + ++
Sbjct:  224 MQSHYFVALYRFKALEKDDLDFQAGERITVIDDSNEEWWRGKVGEKAGYFPANFIIRVRAAERVYKVTRSF-VGNREIGQITLKKDQIVVQKGDEVNGYIKVSTGRKVGLF-PLDFLQEI 341

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
Match: STAC2 (SH3 and cysteine rich domain 2 [Source:NCBI gene;Acc:100491407])

HSP 1 Score: 74.3294 bits (181), Expect = 3.844e-13
Identity = 35/115 (30.43%), Postives = 61/115 (53.04%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            YVALY F  ++ ++L L+ G +V  +D S+ DWW GKC  + G+FPAN+VQ +  GE VW+  +    +   Q  + L + Q+ V     + +  +  +        P +C+ ++
Sbjct:  292 YVALYKFLPQEINDLPLQPGDRVMVLDDSNEDWWKGKCGDRTGFFPANFVQRVRLGETVWKSTKAFQGIK-EQGQLCLKEGQVCVGVAKPETESFIKVSSGKKKGLVPQECLMEI 405

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
Match: hcls1 (hematopoietic cell-specific Lyn substrate 1 [Source:NCBI gene;Acc:496771])

HSP 1 Score: 56.225 bits (134), Expect = 2.899e-7
Identity = 23/54 (42.59%), Postives = 32/54 (59.26%), Query Frame = 3

Query: 2781 GNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            G   VALYD+     DE++ +    ++ ID+ D  WW G C G+ G FPANYV+
Sbjct:  493 GICAVALYDYEGGGDDEISFQPQELITDIDMLDEGWWCGTCEGRRGLFPANYVE 546

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
Match: adamts8 (ADAM metallopeptidase with thrombospondin type 1 motif 8 [Source:Xenbase;Acc:XB-GENE-994782])

HSP 1 Score: 55.4546 bits (132), Expect = 4.194e-7
Identity = 22/50 (44.00%), Postives = 32/50 (64.00%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQA 2945
            A+YDF   + +EL  +AG  V+ +D SD +WW G+ N   G FP+N+V A
Sbjct:  215 AIYDFEAAEDNELTFKAGDIVTVLDDSDPNWWKGETNEGIGLFPSNFVTA 264

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Mouse
Match: Stac3 (SH3 and cysteine rich domain 3 [Source:MGI Symbol;Acc:MGI:3606571])

HSP 1 Score: 77.411 bits (189), Expect = 1.594e-14
Identity = 40/115 (34.78%), Postives = 63/115 (54.78%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T      + P D + ++
Sbjct:  248 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLF-PTDFLEEI 360

[Close]

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T      + P D + ++
Sbjct:  248 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLF-PTDFLEEI 360

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Mouse
Match: Stac2 (SH3 and cysteine rich domain 2 [Source:MGI Symbol;Acc:MGI:2144518])

HSP 1 Score: 77.0258 bits (188), Expect = 3.858e-14
Identity = 45/120 (37.50%), Postives = 66/120 (55.00%), Query Frame = 3

Query: 2730 EENISKQYTKKLGYRLR-GNLY--VALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTG-SQDGDQIL 3077
            EE    Q   KL  R   G +Y  VALY F  ++ ++L L+ G ++  +D S+ DWW GK   + G+FPAN+VQ +  GE+VWR  +  S  +  Q  + L +NQI V    S+D D  +
Sbjct:  271 EEKSPGQQPPKLPLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFS-GNKEQGYMSLKENQICVGVSRSKDSDGFI 389

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Mouse
Match: Stac (src homology three (SH3) and cysteine rich domain [Source:MGI Symbol;Acc:MGI:1201400])

HSP 1 Score: 74.7146 bits (182), Expect = 2.182e-13
Identity = 37/99 (37.37%), Postives = 60/99 (60.61%), Query Frame = 3

Query: 2775 LRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIRE-VSVVDSNQTPVRLYKNQILVQT-GSQDG 3065
            L+ N YVALY F  ++ ++L +R G  ++ ++ S+ DWW GK   + G+FPAN+VQ + + E ++R +R  +   D  Q  + L +NQI V +   QDG
Sbjct:  286 LQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGFFPANFVQRVEEHEKIYRCVRTFIGCKDQGQ--ITLKENQICVTSEEEQDG 382

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Mouse
Match: Grap2 (GRB2-related adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1333842])

HSP 1 Score: 60.4622 bits (145), Expect = 4.269e-9
Identity = 25/51 (49.02%), Postives = 33/51 (64.71%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAI 2948
            ALYDF   ++DEL  R+G  V  +D S+  WWTG+ + K G FPANYV  +
Sbjct:  270 ALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPM 320

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
Match: sp|Q6ZMT1|STAC2_HUMAN (SH3 and cysteine-rich domain-containing protein 2 OS=Homo sapiens OX=9606 GN=STAC2 PE=1 SV=1)

HSP 1 Score: 83.9593 bits (206), Expect = 1.575e-15
Identity = 42/116 (36.21%), Postives = 67/116 (57.76%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTG-SQDGDQILIRTKINTTFWCPIDCVTKV 3134
            YVALY F  ++ ++L L+ G ++  +D S+ DWW GK   + G+FPAN+VQ +  GE+VWR  +  S  +  Q  + L +NQI V  G S+D D  +  +        P+D +T++
Sbjct:  297 YVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFS-GNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 411

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
Match: sp|A0JNJ1|STAC_BOVIN (SH3 and cysteine-rich domain-containing protein OS=Bos taurus OX=9913 GN=STAC PE=2 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 2.761e-14
Identity = 39/98 (39.80%), Postives = 60/98 (61.22%), Query Frame = 3

Query: 2775 LRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQT-GSQDG 3065
            L+ N YVALY F  ++ ++L +R G  ++ ++ S+ DWW GK   + G+FPAN+VQ +HQ E ++R +R  S     Q  + L +NQI V +   QDG
Sbjct:  286 LQMNTYVALYKFVPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRIGFFPANFVQRVHQNEKIFRCVRTFSGC-KEQGQITLKENQICVASEEEQDG 382

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
Match: sp|Q68F99|STAC3_XENTR (SH3 and cysteine-rich domain-containing protein 3 OS=Xenopus tropicalis OX=8364 GN=stac3 PE=2 SV=1)

HSP 1 Score: 77.7962 bits (190), Expect = 7.162e-14
Identity = 40/120 (33.33%), Postives = 69/120 (57.50%), Query Frame = 3

Query: 2775 LRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            ++ + +VALY F   +KD+L+ +AG +++ ID S+ +WW GK   K GYFPAN++  +   E V++V R   V +     + L K+QI+VQ G +    I + T      + P+D + ++
Sbjct:  220 MQSHYFVALYRFKALEKDDLDFQAGERITVIDDSNEEWWRGKVGEKAGYFPANFIIRVRAAERVYKVTRSF-VGNREIGQITLKKDQIVVQKGDEVNGYIKVSTGRKVGLF-PLDFLQEI 337

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
Match: sp|Q96MF2|STAC3_HUMAN (SH3 and cysteine-rich domain-containing protein 3 OS=Homo sapiens OX=9606 GN=STAC3 PE=1 SV=1)

HSP 1 Score: 77.7962 bits (190), Expect = 9.829e-14
Identity = 40/115 (34.78%), Postives = 63/115 (54.78%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T      + P D + ++
Sbjct:  252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLF-PTDFLEEI 364

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
Match: sp|Q8BZ71|STAC3_MOUSE (SH3 and cysteine-rich domain-containing protein 3 OS=Mus musculus OX=10090 GN=Stac3 PE=1 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 1.115e-13
Identity = 40/115 (34.78%), Postives = 63/115 (54.78%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +VALY F   +KD+L+   G K++ ID S+ +WW GK   K G+FP N++  +  GE V RV R   V +     + L K+QI+VQ G + G  + + T      + P D + ++
Sbjct:  248 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSF-VGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLF-PTDFLEEI 360

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
Match: A0A4Z2DES4 (Tyrosine-kinase Fes Fps-like isoform X5 OS=Schistosoma japonicum OX=6182 GN=EWB00_001753 PE=4 SV=1)

HSP 1 Score: 184.111 bits (466), Expect = 1.043e-46
Identity = 116/377 (30.77%), Postives = 199/377 (52.79%), Query Frame = 3

Query:  258 HNMTYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSLTSSN----------YSSDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQRE----IIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGL-KTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQL 1343
            H   ++ L+H SY+  + + +   ++++D    +++++++  + +  +L  IC   ++++ ++            +    DLW   ++   +EA+++          V NPL+ I  ++  Q  +L  FR S +  L + S+ + +L  +Y + Y++ RE    K I  LLNAHN+YVLQL  +N MK  YH+  LP ++ E ETI RE     IQIF     ++    A    QLI   + +   +K ++PD  +   V+ LN N+  ++W   ++LPPDGDCPEIL  D VI D L    LQ   + L ++  EL SF+ QN +++ TLK L K   F     +  L  + DDI RK++E+R A++ +AG+  Q+
Sbjct:   44 HITGFQLLSHKSYYPFMIESITHQLDLLDKFVLVIEQITDARQLYSTTLKNICQSLTENVENTESIKNDNNINDNNEVLFDLWRTFVEKAHNEAELHDNTVQQTKEKVVNPLKWIVKNRRQQISRLKAFRTSTDSTLKECSEKVIELQSNYAEMYRIYREVIQTKTIKDLLNAHNSYVLQLHMTNTMKAYYHNLILPQLMQEFETIVRENTTEFIQIFD----YFCSIHANMFDQLICNNNGVQIKMKEITPDAIVSIIVQNLNKNKNPTHWHLMEYLPPDGDCPEILCSDHVIIDNLVKIELQCKFNELKRQFAELSSFMQQNVNIVDTLKSLEKRYNFDTQVGYTHL-NMHDDIYRKEDEIRKARIALAGIEVQI 415

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
Match: A0A183LF27 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS2402 PE=4 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 1.017e-44
Identity = 106/373 (28.42%), Postives = 199/373 (53.35%), Query Frame = 3

Query:  270 YRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSLTS----------SNYSSDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQRE----IIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKL-YELDDDICRKQNEVRMAQVQVAGVIAQL 1343
            ++ L+H +Y+  +   +   +++I+    +++++++  +++  ++  +C  F +S+            +N +    + W++ ++ F +EA+++     +  + V  PL+ I  H+  Q  +L  FR S +  L + ++ + +L  +Y + Y++ RE    K I  LLNAHN+YVLQL  +N MK  YH+  LP ++ E E I RE     +QIF     ++         QLI   + +   ++ +SPD  +   V  LN NQ  ++W+  ++L PD DCPEIL  + +I D L    L+   + L ++ +EL SF+ QN +++ TLK L+   F +    E   + + DDI RK+NE+R A++ +AG+  Q+
Sbjct:    6 FQFLSHKNYYPLMIDSITHQLDLIEKFVSVIEQMTDARQSYSIAIKNVCQSFKESVEKVESIKKDSDINNNNEILYNFWHVFIEKFQNEAELHENVIQETKAKVVTPLQCIVKHRRQQISRLKAFRTSTDYTLKECAEKVNELQSNYAEMYRIHREILQTKAIKDLLNAHNSYVLQLHMTNAMKAYYHNLVLPQLMQEFEDIVRENMIGFVQIFE----YFCSIHTNMFDQLICNINGVQLKVREISPDSVVSVIVHNLNKNQNPTHWQLIEYLSPDCDCPEILCSNQIIIDNLVKVELRDKFNELKRQFSELSSFMQQNVNIVDTLKTLE-KRFDFDTQTEHTNFNMHDDIYRKENEIRKAKIALAGIEIQV 373

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
Match: A0A3Q0KT18 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 173.711 bits (439), Expect = 6.432e-43
Identity = 107/369 (29.00%), Postives = 198/369 (53.66%), Query Frame = 3

Query:  270 YRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSL----------TSSNYSSDFL-DLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKL-YELDDDICRKQNEVRMAQVQVAGVIAQ 1340
            ++ L+H +Y+  +   +   +++I+    +++++++  +++  +L  +C  F +S+          + +N +++ L +  ++ ++ F SEA+++     +  + V  PL++I  H+  Q  +L +FR S +  L +  + + +L  +Y + Y++ RE    K I  LLNAHN+YVLQL  +N MK  YH+  LP ++ E E I RE I  F     ++         QLI   + +   +K +SPD  +   V  LN NQ  ++W+  ++L PD DCP+IL  + +I D L    L+   + L ++  EL SF+ QN +++ TLK L+   F +    E     + DDI RK+NE+R A++ +AG+  Q
Sbjct:   70 FQFLSHKNYYPLMIDSITHQLDLIEKFVSVIEQMTDARQSYSMALKNVCQSFKESIEKVESVNKNDSDTNNNNEILHNFCHVFIEKFQSEAELHENVIHETKAKVVTPLQSIVKHRRQQISRLKDFRASTDYTLKECGEKVIELQSNYAEMYRIHRELLKTKAIKDLLNAHNSYVLQLHMTNAMKAYYHNLVLPQLMKEFEDIVRENIIGFVQIFDYFCSIHTSMFDQLICNINGVQLKVKEISPDSVVSVIVHNLNRNQNPTHWQLIEYLSPDCDCPDILCSNQIIVDNLVKVELREKFNELKRQFAELSSFMQQNINIVDTLKTLE-KRFDFDTQTEHTNLNMHDDIYRKENEIRKAKIALAGIEVQ 437

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
Match: A0A1S3JKS6 (uncharacterized protein LOC106174122 isoform X5 OS=Lingula unguis OX=7574 GN=LOC106174122 PE=4 SV=1)

HSP 1 Score: 180.259 bits (456), Expect = 1.321e-42
Identity = 233/989 (23.56%), Postives = 424/989 (42.87%), Query Frame = 3

Query:  267 TYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSL-----TSSNYSSDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYID---QYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSL-CHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEI--LARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTL-KGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQLQHIDNKKFSGFALKDEED----------TGMKRIWKKAVFSLKRDKGS--KNQSIL-KNIKKESFRPASSPLQNTFQNDDSKVDPVYHLLRCAASKSHLSSFQCDLRDSNSSPTPKYNEMAFQTSNGRLSLIQTAFNMA-NLSRRRLLLCQTKAKSSSVEEGGQVGDDKILNSSNLHSHWLDTINTDSRENSHRGSVSKPNNYIKSSIPINNQKCVKGKLKTMFHSATVSQPPDEQLLDKGISKSPVFHSDIMH--RKLN-ERMKSFSVDNPDKVSNTASSPPSISRDN-RKMSSSYTNTKLYDSNVPISPRRRKTLYGRKKSCSLDQENHA--TSRRVAFADESMTRKADRSYDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEKEE-NSESEINHQTFPTNSNXXXXXXXXXXXXXSYSPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEENISKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            +++DL        I Q M  ++ +   + +  ++++  +  F   +      F K       +S    S     W  L++    ++ ++ +        V  PL  ++A+K    +++  F      +L      +++ +++Y+D   +YQ  ++ Y  KL      AHN Y+LQL + N++  +Y+  ALP +L ELE I+ +     + +L  H     +K + Q   ++  IL   K L P   I++FV+ L     V     ++F PPD +   I  L  D +I ++ T   L   +S L K+   LLS I    + I+TL +  K N  ++   + KLYE+ +++C K+NEVR+A++Q+A +  Q++ +  K+    + K +E+            +K +WKKA  +LKR   +  K Q+   K+++K +            Q +    +P           + L S +  L      P+ +  E   Q +N  +  + +    A NL + +  +C               GD     SS +  H     +  SR NS   ++S       S++ +   +   GK       ++VSQP    L        P  +S+I    RKL  E     S    D V + + S  +   D+ R +S+ Y     Y  +     RR   L  R KS S D++  A    RR      S+TR+     D S+              ++  N   S +  P  N  R+KSFS+D+P+     S+ EI+ ++                   + SP H+ K+        +++ S++    I V+  +              +    +      R +  LY++LY++   ++ +L ++AGW++ AI+ SD +WW G+CNGK GYFPA YV A+   +  + V + + + +  +   +L K+QI+VQ GS     + +R+  +    CP+  +++V
Sbjct:    9 SFQDLRQPGMQDTIRQHMGATLKLAKTMAEFSQKIAAVHTQFASQMQASVEMFKKRSHELRESSVEMPSIMQTTWEDLIREVEVDSYMHTDLASRLTKNVYQPLMDLAAYKRGHVKRMTSFGEHYLSLLQKAEADLDKANKNYVDCFIRYQENKDTY--KLQSAYHVAHNEYLLQLKSFNQLSTEYYDMALPGLLQELEDIELDTGLALNGALESHVMLILSKSNEQYKRYEG-ILHLCKQLDPKVDIVHFVKHLKPQPFVIDSVLQEFRPPDPNSGNIENLLDDQLILNRGTQTVLDSKQSILEKQAANLLSEIQFQQESIATLTEECKKNIANHQ--YGKLYEIQEELCSKRNEVRIAKMQLAAIKPQIELLSPKQNGNMSSKAKEEKEASKPLHSAGSIKSMWKKAFKNLKRSSSTIEKTQTAAEKDVEKST---------EDEQPEKEAGEPE------VGRSTRLGSLRRSLM--RKKPSKEEEEEDEQPANHEIDPVYSLLKCAGNLPKNKGHIC---------------GD-----SSCMMQHSPSGQHIYSRSNS---AMSTGRTSPSSTLAVQQDQAYGGKRSPDHRRSSVSQPISHNL------SFPEIYSEIQRERRKLMIEAHHQHSQSLTDSVGSLSGSEDAYKVDSSRVLSAPYLEQSNYGGS-----RRPPMLNSRMKSQSADEKAVANLAGRRC-----SITRQ-----DASV-KPCGVSEIPAPGPLLGAN--GSRRRIPRLNE-RMKSFSIDVPDAAHVMSDPEISKRS------------------NTLSPYHERKKFT------DRTNSLDDPGYISVSQSS--------------HSPSPHPSPPQSRRKSKLYLSLYNWRGSERGDLEIKAGWRIKAIETSDNNWWKGRCNGKVGYFPAKYVTAVEPDQKAYIVKQGLQLSEEGKD-FKLLKDQIVVQAGSIKDGMVPVRSG-DKQMPCPLKYLSEV 887

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
Match: A0A430QJV2 (Uncharacterized protein (Fragment) OS=Schistosoma bovis OX=6184 GN=DC041_0011087 PE=4 SV=1)

HSP 1 Score: 164.851 bits (416), Expect = 1.460e-40
Identity = 100/368 (27.17%), Postives = 191/368 (51.90%), Query Frame = 3

Query:  270 YRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSL---------TSSNYSSDFL-DLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKL-YELDDDICRKQNEVRMAQVQVAGVIAQ 1340
            ++ L+H +Y+  +   +   +++I+    +++++++  +++  ++  +C  F +S+         + +N +++ L + W++ ++ F +EA+++     +  + V  PL+ I  H+  Q  +L  FR S +  L + ++ + +L  +Y + Y++ RE    K I  LLNAHN+YVLQL  +N MK  YH+  LP ++             F   +C+ +G   K               ++ +SPD  +   V  LN NQ  ++W+  ++L PD DCPEIL  + +I D L    L+   + L ++  EL SF+ QN +++ TLK L+   F +    E     + DDI RK+NE+R A++ +AG+  Q
Sbjct:   26 FQFLSHKNYYPLMIDSITHQLDLIEKFVSVIEQMTDARQSYSIAIKNVCQSFKESVEKVESIKKDSDTNNNNEILYNFWHVFIEKFQNEAELHENVIQETKAKVVTPLQCIVKHRRQQISRLKAFRTSTDYTLKECAEKVNELQSNYAEMYRIHREILQTKAIKDLLNAHNSYVLQLHMTNAMKAYYHNLVLPQLMQ------------FDQLICNINGVQLK---------------VREVSPDSVVSVIVHNLNKNQNPTHWQLIEYLSPDCDCPEILCSNQIIVDNLVKVELRDKFNELKRQFAELSSFMQQNVNIVDTLKTLE-KRFDFDTQTEHTNLNMHDDIYRKENEIRKAKIALAGIEVQ 365

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Cavefish
Match: STAC3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:103033422])

HSP 1 Score: 80.8777 bits (198), Expect = 8.213e-16
Identity = 44/139 (31.65%), Postives = 75/139 (53.96%), Query Frame = 3

Query: 2718 KEHIEENISKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            K   E+ + K    KLG   + + Y+ALY F   +KD+L+L  G +++ ID S+ +WW GK   + G+ PANY+  +  GE V++V R   V +     + L K+QI+V+ G +    + + T     F+ P D + ++
Sbjct:  208 KAAAEDKMKKPVLGKLGVFSQSHYYLALYRFKAIEKDDLDLHPGDRITVIDDSNEEWWRGKIGERSGFLPANYIIRVRSGERVYKVTRSF-VGNREMGQITLKKDQIVVKKGDEVNGYLKVSTGRKLGFF-PADILQEI 344

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Cavefish
Match: STAC2 (SH3 and cysteine rich domain 2 [Source:HGNC Symbol;Acc:HGNC:23990])

HSP 1 Score: 73.9442 bits (180), Expect = 2.428e-13
Identity = 36/85 (42.35%), Postives = 51/85 (60.00%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILV 3044
            YVALY F  +++++L L  G +V   D S+ +WW GK   K G+FPAN+VQ +  GE VWRV  E S  D     + + ++QI V
Sbjct:  265 YVALYRFLPQEQNDLELHPGDRVQVTDDSNEEWWKGKSGDKVGFFPANFVQRVRPGERVWRVT-ECSEGDRQLGHMPVKEDQICV 348

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Cavefish
Match: grap2a (GRB2-related adapter protein-like [Source:NCBI gene;Acc:103029038])

HSP 1 Score: 60.8474 bits (146), Expect = 1.667e-9
Identity = 28/58 (48.28%), Postives = 34/58 (58.62%), Query Frame = 3

Query: 2778 RGNLYV-ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAI 2948
            R  L V A+YDF   ++DEL   AG  +  ID SDA WW G+  G+ G FPANY   I
Sbjct:  230 RSTLQVKAMYDFIAEEEDELGFNAGDIIEVIDRSDASWWKGRLQGRTGLFPANYTAPI 287

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Query: 2778 RGNLYV-ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAI 2948
            R  L V A+YDF   ++DEL   AG  +  ID SDA WW G+  G+ G FPANY   I
Sbjct:  230 RSTLQVKAMYDFIAEEEDELGFNAGDIIEVIDRSDASWWKGRLQGRTGLFPANYTAPI 287

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Cavefish
Match: grap2a (GRB2-related adapter protein-like [Source:NCBI gene;Acc:103029038])

HSP 1 Score: 59.6918 bits (143), Expect = 2.484e-9
Identity = 25/51 (49.02%), Postives = 31/51 (60.78%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAI 2948
            A+YDF   ++DEL   AG  +  ID SDA WW G+  G+ G FPANY   I
Sbjct:  178 AMYDFIAEEEDELGFNAGDIIEVIDRSDASWWKGRLQGRTGLFPANYTAPI 228

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009546.1 (pep scaffold:Pmarinus_7.0:GL485512:1487:9666:1 gene:ENSPMAG00000008635.1 transcript:ENSPMAT00000009546.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 68.9366 bits (167), Expect = 4.326e-14
Identity = 35/90 (38.89%), Postives = 51/90 (56.67%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQ 3059
            YV LY F  ++KD+L L  G ++  ID S+ +WW GK   K GYFPAN+V  +  GE V R+ R   V +     + L + Q+ V+ G +
Sbjct:   19 YVVLYKFVAQEKDDLQLTPGQRLIVIDDSNEEWWKGKMGDKLGYFPANFVIRVRAGERVLRLSRTF-VGNKQLGQITLKQGQVCVEKGEE 107

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 69.707 bits (169), Expect = 5.553e-13
Identity = 33/90 (36.67%), Postives = 54/90 (60.00%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQ 3059
            +VAL+ F  R+KD+L L  G ++S +D S+ +WW GK   + GYFPAN+V  +  GE V++ +R   V +     + L + Q+ V+ G +
Sbjct:  197 FVALHRFGTREKDDLALEPGDRLSILDDSNEEWWKGKLGDRVGYFPANFVVRVRPGERVFQALRTF-VGNKQLGQLTLKQEQVCVEKGGE 285

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
Match: stac (SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-GENE-131121-459])

HSP 1 Score: 65.4698 bits (158), Expect = 2.299e-11
Identity = 36/116 (31.03%), Postives = 62/116 (53.45%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKIN-TTFWCPIDCVTKV 3134
            YVAL  +  +   +L ++ G  +S +D S+ +WW G+ + + G+FPAN+VQ +  GE V+R +R  +    +   + L   QI V+  S    Q L+R +        PIDC+ ++
Sbjct:  262 YVALSQYVPQDSGDLAIQPGDILSIVDDSNEEWWKGRIDDRVGFFPANFVQRVRPGERVFRCVRACAGTREHGQ-LALNLEQICVEKASMPA-QGLVRVQSGRKKGLVPIDCLEEI 375

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
Match: stam (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:ZFIN;Acc:ZDB-GENE-031118-123])

HSP 1 Score: 56.9954 bits (136), Expect = 1.253e-8
Identity = 23/50 (46.00%), Postives = 32/50 (64.00%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQA 2945
            ALYDF   + +EL  RAG  ++ +D SDA+WW G+     G FP+N+V A
Sbjct:  217 ALYDFEAAEDNELTFRAGEILTVLDDSDANWWKGETESGLGLFPSNFVTA 266

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
Match: grb2a (growth factor receptor-bound protein 2a [Source:ZFIN;Acc:ZDB-GENE-041121-1])

HSP 1 Score: 54.299 bits (129), Expect = 2.963e-8
Identity = 22/48 (45.83%), Postives = 31/48 (64.58%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYV 2939
            AL+DF  ++  EL  R G  ++ +D SD +WW G C+G+ G FP NYV
Sbjct:  164 ALFDFEPQEDGELGFRRGDFITVVDSSDPNWWKGSCHGRAGMFPRNYV 211

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
Match: PIN3 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication [Source:SGD;Acc:S000006358])

HSP 1 Score: 56.9954 bits (136), Expect = 1.760e-9
Identity = 32/89 (35.96%), Postives = 44/89 (49.44%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQD 3062
            ALY F  +Q  +L L+ G KV  ++    +W+ G CNG+ G FPANYV+    G +            SN  P   YK Q L Q  +Q+
Sbjct:   61 ALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKPAFSGSN----------GPSNLPPPPQYKAQELQQIPTQN 139

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BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
Match: LSB1 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368])

HSP 1 Score: 55.0694 bits (131), Expect = 1.267e-8
Identity = 25/52 (48.08%), Postives = 34/52 (65.38%), Query Frame = 3

Query: 2790 YV-ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            YV ALYDF  +Q  +L+L+ G K+  ++    DW+ GK N K G FPANYV+
Sbjct:   57 YVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVK 108

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
Match: YSC84 (Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication [Source:SGD;Acc:S000001058])

HSP 1 Score: 54.6842 bits (130), Expect = 5.252e-8
Identity = 25/52 (48.08%), Postives = 34/52 (65.38%), Query Frame = 3

Query: 2793 VALYDFWCRQKDELNLRAGWKVSAIDISDA--DWWTGKCNGKFGYFPANYVQ 2942
            VALY+F   Q  +L  + G  ++ +  SD+  DWWTG+ NGK G FPANYV+
Sbjct:  415 VALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVR 466

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
Match: LSB3 (Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication [Source:SGD;Acc:S000002968])

HSP 1 Score: 54.299 bits (129), Expect = 7.174e-8
Identity = 24/54 (44.44%), Postives = 34/54 (62.96%), Query Frame = 3

Query: 2793 VALYDFWCRQKDELNLRAGWKVSAIDISDA--DWWTGKCNGKFGYFPANYVQAI 2948
            VALY F   +  +L  R G  ++ +  SD+  DWWTG+ NG+ G FPANYV+ +
Sbjct:  406 VALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV 459

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
Match: HSE1 (Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994])

HSP 1 Score: 51.9878 bits (123), Expect = 3.188e-7
Identity = 21/51 (41.18%), Postives = 27/51 (52.94%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAI 2948
            ALYD    + DEL+ R G  ++ ++    DWW G   G  G FP NYV  I
Sbjct:  224 ALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPI 274

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
Match: EDO36303 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIY7])

HSP 1 Score: 78.5666 bits (192), Expect = 4.684e-15
Identity = 103/465 (22.15%), Postives = 187/465 (40.22%), Query Frame = 3

Query:  249 ACAHNMTYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSLTSSNYS----SDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQ----YQLQ------REKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSL----SPDDQIINFVRQLNTNQAVSYWRREQFLPPDG--DCPEILARDDVISDKLTVEPLQHI-----RSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQLQHIDNKKFSGFA-------------LKDEE---DTGMKRIWKK-------AVFSLKRDKGSKNQSILKNIKKESF 1499
            A     T R++   S +  +       + I+    + + ++    E   + L  +   F +            S  + LW  LL  + +EAQ   + C      +   L   ++ + +  +K++ FR + E  ++   D   + HRDY +      ++Q      +E      I    NAHN+YVLQL A N M D ++++ LP +LD+L+ IQ E      ++  +     A+  RQ  D + + L S + +    +    I NFV+  N           QF PP    + PE      V   KL+V  L           L K+   L   + +    I ++ GLK + +S + S+ +   +D ++  ++NE+R+ ++         + I N + S F              L+DEE   D  +  I+ K       A+   K  + +K++ +  N +K  F
Sbjct:    2 AAVRGGTLREMVDPSANETLKSNSHSCVKILKTAGEFVSKICAVKEQCANQLLSVVETFKRKSAEMKKERGALSSAMSLWETLLLEYETEAQDMLKLCSKLSKDISKSLSDEASKRKALYKKIFTFREAGEARISKADDARAKCHRDYCEACAKLAKVQNSADQSKEGKQEHYITMCHNAHNSYVLQLSAVNGMTDVFYTKTLPQMLDDLQAIQEETAMAMSATFKN----CAEIERQNHDDRSKRLQSFEGMFELVNSSQDIENFVKTNNPG---------QFTPPKKLFEKPEDGTVVSVPDGKLSVHALTETVLKRKYITLYKKFRNLSDDVEKERHAIISVSGLK-DSYSKNPSYGRADTVDANLLEQKNEMRLKEM--------YKEITNDQLSLFTPDVMTKLSVSDVDLQDEEYDDDESLTNIYDKRQSVITSAMAKPKTTRAAKHEFVEHNFRKPQF 444

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
Match: EDO50032 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RF47])

HSP 1 Score: 52.373 bits (124), Expect = 9.204e-7
Identity = 22/50 (44.00%), Postives = 30/50 (60.00%), Query Frame = 3

Query: 2793 VALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            VALYD+    +DE+       ++ I+  D  WW G CNG+ G FPANYV+
Sbjct:  482 VALYDYQAAGEDEITFDPDDIITDIEKIDDGWWMGTCNGQRGLFPANYVE 531

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
Match: EDO46357 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQF8])

HSP 1 Score: 51.6026 bits (122), Expect = 1.462e-6
Identity = 21/48 (43.75%), Postives = 29/48 (60.42%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYV 2939
            ALYDF   + +EL  + G  +S +D SDA WW G+     G FP+N+V
Sbjct:  239 ALYDFEAAEDNELTFKTGDIISILDDSDASWWKGETPNGTGLFPSNFV 286

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
Match: EDO38076 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SE08])

HSP 1 Score: 49.2914 bits (116), Expect = 1.575e-6
Identity = 22/52 (42.31%), Postives = 34/52 (65.38%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKC--NGKFGYFPANYVQA 2945
            AL+DF  +++ E++ + G  +  ID SD +WW GK    G+ G FP+NYV+A
Sbjct:  137 ALFDFEAQEEGEVSFKRGDCIEVIDNSDVNWWRGKVLTTGEIGMFPSNYVKA 188

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
Match: EDO29864 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2F6])

HSP 1 Score: 47.3654 bits (111), Expect = 1.648e-6
Identity = 22/51 (43.14%), Postives = 30/51 (58.82%), Query Frame = 3

Query: 2793 VALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKC--NGKFGYFPANYV 2939
            VALYDF  ++  ELN + G  +  +D  D +WW G+    G+ G FP NYV
Sbjct:   62 VALYDFVAQEAGELNFKKGNHIEVLDKEDDNWWKGRVAETGEEGLFPRNYV 112

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
Match: STAC2 (SH3 and cysteine-rich domain-containing protein 2 [Source:NCBI gene;Acc:101169458])

HSP 1 Score: 78.1814 bits (191), Expect = 2.143e-14
Identity = 47/160 (29.38%), Postives = 88/160 (55.00%), Query Frame = 3

Query: 2631 ESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEEN------ISKQYTKKLGYRLRGN---LYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIR 3083
            E Q++  SME   +I +   + L      ++ ++E+      +S+  + K+  R+  +    YVALY F  +++++L L  G +V  ID S+ +WW GK   K G+FP+N+VQ +  GE VWRV++  S  +  +  + + ++QI V  G +D  ++ ++
Sbjct:  346 ERQQRQCSME--EEITLETGDTLVADEEMEKEVDESSEQAQVLSEDSSAKIPKRIEVHSIHTYVALYKFLPQEQNDLELHPGDRVQVIDDSNEEWWKGKSGDKIGFFPSNFVQRVRPGERVWRVVQGTS-GNRERGHMAVRESQICV--GKRDDGEVFVK 500

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
Match: STAC2 (SH3 and cysteine-rich domain-containing protein 2 [Source:NCBI gene;Acc:101171286])

HSP 1 Score: 73.559 bits (179), Expect = 4.315e-13
Identity = 47/133 (35.34%), Postives = 73/133 (54.89%), Query Frame = 3

Query: 2586 SYSPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLT---HQKEHIEENISKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRV 2975
            S SP H+++RL      QEK     ++NQ     +    +LT    +K   E+ +S +  K++      + YVALY F  ++K++L L+ G +V   D S+ DWW GK   K G+FPAN+VQ +  GE V++V
Sbjct:  245 SESPCHETERL------QEK-----LENQPIAEEEQIPGMLTPPESEKADSEDRVSLKTPKRVPVHSL-HTYVALYKFLPQEKNDLELQPGDRVQVTDDSNEDWWKGKSGHKVGFFPANFVQRVRPGERVYKV 365

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:101165142])

HSP 1 Score: 71.2478 bits (173), Expect = 8.845e-13
Identity = 37/115 (32.17%), Postives = 63/115 (54.78%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKV 3134
            Y+ALY F   +KD+L+   G ++  +D S+ +WW GK   K GYFP NY+  +   E V++V R   V +     + L K+QI+V+ G + G  + + T     ++ P D + ++
Sbjct:  195 YLALYRFKAIEKDDLDFHPGDRIIVLDDSNEEWWRGKMGEKTGYFPTNYIIKVRASERVFKVTRSF-VGNREMGQITLKKDQIVVKKGDEKGGYLKVSTGRKLGYF-PADLLEEI 307

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:101165142])

HSP 1 Score: 71.2478 bits (173), Expect = 1.377e-12
Identity = 35/103 (33.98%), Postives = 57/103 (55.34%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINT 3098
            Y+ALY F   +KD+L+   G ++  +D S+ +WW GK   K GYFP NY+  +   E V++V R   V +     + L K+QI+V+ G + G  +  +   +T
Sbjct:  218 YLALYRFKAIEKDDLDFHPGDRIIVLDDSNEEWWRGKMGEKTGYFPTNYIIKVRASERVFKVTRSF-VGNREMGQITLKKDQIVVKKGDEKGGYLKFQVGYST 319

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:101165142])

HSP 1 Score: 70.4774 bits (171), Expect = 2.188e-12
Identity = 35/103 (33.98%), Postives = 57/103 (55.34%), Query Frame = 3

Query: 2790 YVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINT 3098
            Y+ALY F   +KD+L+   G ++  +D S+ +WW GK   K GYFP NY+  +   E V++V R   V +     + L K+QI+V+ G + G  +  +   +T
Sbjct:  212 YLALYRFKAIEKDDLDFHPGDRIIVLDDSNEEWWRGKMGEKTGYFPTNYIIKVRASERVFKVTRSF-VGNREMGQITLKKDQIVVKKGDEKGGYLKFQVGYST 313

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST
Match: SMESG000047737.1 (SMESG000047737.1)

HSP 1 Score: 1873.6 bits (4852), Expect = 0.000e+0
Identity = 923/968 (95.35%), Postives = 927/968 (95.76%), Query Frame = 3

Query:  243 MAACAHNMTYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSLTSSNYSSDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQLQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLKRDKGSKNQSILKNIKKESFRPASSPLQNTFQNDDSKVDPVYHLLRCAASKSHLSSFQCDLRDSNSSPTPKYNEMAFQTSNGRLSLIQTAFNMANLSRRRLLLCQTKAKSSSVEEGGQVGDDKILNSSNLHSHWLDTINTDSRENSHRGSVSKPNNYIKSSIPINNQKCVKGKLKTMFHSATVSQPPDEQLLDKGISKSPVFHSDIMHRKLNERMKSFSVDNPDKVSNTASSPPSISRDNRKMSSSYTNTKLYDSNVPISPRRRKTLYGRKKSCSLDQENHATSRRVAFADESMTRKADRSYDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEKEENSESEINHQTFPTNSNXXXXXXXXXXXXXSYSPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEENISKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKVVDNY 3146
            MAACAHNMTYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSLTSSNYSSDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQLQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLKRDKGSKNQSILKNIKKESFRPASSPLQNTFQNDDSKVDPVYHLLRCAASKSHLSSFQCDLRDSNSSPTPKYNEMAFQTSNGRLSLIQTAFNMANLSRRRLLLCQTKAKSSSVEEGGQVGDDKILNSSNLHSHW                                      K++  FHSATVSQPPDEQLLDKGISKSPVFHSDIMHRKLNERMKSFSVDNPD VSNTASSPPSISRDNRKMSSSYTNTKLYDSNVPISPRRRKTLYGRKKSCSLDQE+HATSRRVAFADESMTRKADRSYDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEKEENSESEINHQTFPTNSNLLTPTTVGTTGTLSYSPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEEN+SKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKVVDNY
Sbjct:    1 MAACAHNMTYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETFCDSLSLICTKFSKSLTSSNYSSDFLDLWNLLLQYFSSEAQIYHEFCDDFDSLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQYQLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELETIQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINFVRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSGLLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQNEVRMAQVQVAGVIAQLQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLKRDKGSKNQSILKNIKKESFRPASSPLQNTFQNDDSKVDPVYHLLRCAASKSHLSSFQCDLRDSNSSPTPKYNEMAFQTSNGRLSLIQTAFNMANLSRRRLLLCQTKAKSSSVEEGGQVGDDKILNSSNLHSHW--------------------------------------KIENHFHSATVSQPPDEQLLDKGISKSPVFHSDIMHRKLNERMKSFSVDNPDNVSNTASSPPSISRDNRKMSSSYTNTKLYDSNVPISPRRRKTLYGRKKSCSLDQESHATSRRVAFADESMTRKADRSYDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEKEENSESEINHQTFPTNSNLLTPTTVGTTGTLSYSPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEENLSKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKVVDNY 930

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST
Match: SMESG000039140.1 (SMESG000039140.1)

HSP 1 Score: 186.808 bits (473), Expect = 7.384e-50
Identity = 131/380 (34.47%), Postives = 208/380 (54.74%), Query Frame = 3

Query: 2055 IMHRKLNERMKSFSVDNPDKVSNTASSP--PSISRDNRKMSSSYTNTKLYDSNVPISPRRRKTLYGRKKSCSLDQENHA----------TSRRVAFADESMTRKADRSYDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEKEEN-SESEINHQTFPTNSNXXXXXXXXXXXXXSY-SPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEENISKQYTKKL--GYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKINTTFWCPIDCVTKVVDNY 3146
            +  R+L+ RMKS SVDNP+   +  +     SI   +R+ S+S+TNT   +SN P S  RRK L  + +S S++ E+HA          ++  +  +D    R++ R Y N I    +++S + S   ++K+   +++T     +W++KSFS+D+P+ + + S S   +     NS+  +P    +    S  SP HD++       S +++      N I   +     + +HQ  H       ++        RL  N YV LYDF+ R+ DEL+L+AGWKV+ ++ SD DWWTG+CNG+ GYFPA YVQ IH G  VW+++R++S+ D +    +L K +I+VQ GSQD + I I  K  +  WCPID V K+ D+Y
Sbjct:  195 VPRRRLDARMKSLSVDNPEVEIHEENEDIDDSIYHQSRQFSNSFTNTNAIESN-PYS-MRRKYLKEQHRSISMENEHHAIVTSSCENYRSNSSIKSSDVISPRQSSR-YINVI----SDESKRNSQSSVTKSNLRTTRT-----NWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESL----IASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEIVVQQGSQDSESIPICIKRVSYLWCPIDYVGKIFDDY 558

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST
Match: SMESG000038704.1 (SMESG000038704.1)

HSP 1 Score: 63.1586 bits (152), Expect = 2.199e-10
Identity = 39/111 (35.14%), Postives = 64/111 (57.66%), Query Frame = 3

Query: 2631 ESQEKSLSMEIDNQIEVNNKN-NLKVLTHQKEHI------EENISKQYTKKLGYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ 2942
            E+Q + ++ +++ Q+E+N  N N     H+++HI      E++  K+          G + VAL+DF   ++DE+N  AG K+  I+  DA WW G+ NG+ G FP+NYVQ
Sbjct:  159 EAQVEHVTRDVE-QLEINEPNRNDDSNEHEQQHIPIVEKEEKHHDKEENVVQAVGNEGIVAVALFDFDGEEEDEINFVAGEKIVNIEKIDACWWVGELNGRRGMFPSNYVQ 268

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST
Match: SMESG000073128.1 (SMESG000073128.1)

HSP 1 Score: 51.9878 bits (123), Expect = 2.666e-6
Identity = 21/53 (39.62%), Postives = 33/53 (62.26%), Query Frame = 3

Query: 2796 ALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCN--GKFGYFPANYVQAI 2948
            A++++ C+  DE++   G  ++ I+  D  WW G CN  GK G FP+NYV+ I
Sbjct:  561 AVFEYECQDSDEIDFEVGEIITDIEEIDEGWWIG-CNKSGKRGMFPSNYVELI 612

[Close]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST
Match: SMESG000059156.1 (SMESG000059156.1)

HSP 1 Score: 47.7506 bits (112), Expect = 8.449e-6
Identity = 37/113 (32.74%), Postives = 56/113 (49.56%), Query Frame = 3

Query: 1284 RKQNEVRMAQVQVAGVIAQLQHIDNKKFSG-------FALKDEEDTGM-KRIWKKAVFSLKRDKGSKNQSILKNIKKESFRPASSPLQNTFQNDDSKVDPVYHLLRCAASKSH 1598
            R  N  R+  +Q++   + L  ID+K F         ++ + E DT   K  W +A+ SLKR    K ++  K + K    P  S  +     ++S VDPVYHLLRCA+  +H
Sbjct:   42 RYLNSKRLLNMQLSKSESYLNKIDSKYFHSNESTQRKYSHEGEPDTKNDKPFWSQAIVSLKR----KQEAFFKKLPK----PHQS--EEVPVVEESTVDPVYHLLRCASYTAH 144

The following BLAST results are available for this feature:

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Zebrafish
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Mouse
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Cavefish
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
STAC2	3.280e-16	36.21	SH3 and cysteine rich domain 2 [Source:HGNC Symbol...	[more]
STAC3	7.458e-16	34.78	SH3 and cysteine rich domain 3 [Source:HGNC Symbol...	[more]
STAC3	2.047e-14	34.78	SH3 and cysteine rich domain 3 [Source:HGNC Symbol...	[more]
STAC3	3.227e-14	38.38	SH3 and cysteine rich domain 3 [Source:HGNC Symbol...	[more]
STAC	6.281e-14	37.76	SH3 and cysteine rich domain [Source:HGNC Symbol;A...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
itsn-1	3.822e-7	42.31	ITSN (Intersectin) family [Source:UniProtKB/TrEMB...	[more]
itsn-1	3.918e-7	42.31	ITSN (Intersectin) family [Source:UniProtKB/TrEMB...	[more]
itsn-1	4.993e-7	42.31	ITSN (Intersectin) family [Source:UniProtKB/TrEMB...	[more]
itsn-1	5.033e-7	42.31	ITSN (Intersectin) family [Source:UniProtKB/TrEMB...	[more]
itsn-1	8.294e-7	42.31	ITSN (Intersectin) family [Source:UniProtKB/TrEMB...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Stacl	2.416e-23	24.94	gene:FBgn0263980 transcript:FBtr0344200	[more]
Stacl	5.718e-23	24.94	gene:FBgn0263980 transcript:FBtr0344202	[more]
Stacl	6.659e-23	24.94	gene:FBgn0263980 transcript:FBtr0475071	[more]
Stacl	7.255e-23	24.94	gene:FBgn0263980 transcript:FBtr0330007	[more]
Stacl	7.802e-23	24.94	gene:FBgn0263980 transcript:FBtr0344206	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
stac3	7.499e-12	32.14	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
stac3	7.499e-12	32.14	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
stac3	7.571e-12	32.73	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
grap2a	2.056e-8	45.10	GRB2 related adaptor protein 2a [Source:ZFIN;Acc:Z...	[more]
stac	5.254e-8	30.48	SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
stac3	1.251e-14	33.33	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
stac3	2.109e-14	33.33	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
STAC2	3.844e-13	30.43	SH3 and cysteine rich domain 2 [Source:NCBI gene;A...	[more]
hcls1	2.899e-7	42.59	hematopoietic cell-specific Lyn substrate 1 [Sourc...	[more]
adamts8	4.194e-7	44.00	ADAM metallopeptidase with thrombospondin type 1 m...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Stac3	1.594e-14	34.78	SH3 and cysteine rich domain 3 [Source:MGI Symbol;...	[more]
Stac3	1.594e-14	34.78	SH3 and cysteine rich domain 3 [Source:MGI Symbol;...	[more]
Stac2	3.858e-14	37.50	SH3 and cysteine rich domain 2 [Source:MGI Symbol;...	[more]
Stac	2.182e-13	37.37	src homology three (SH3) and cysteine rich domain ...	[more]
Grap2	4.269e-9	49.02	GRB2-related adaptor protein 2 [Source:MGI Symbol;...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6ZMT1\|STAC2_HUMAN	1.575e-15	36.21	SH3 and cysteine-rich domain-containing protein 2 ...	[more]
sp\|A0JNJ1\|STAC_BOVIN	2.761e-14	39.80	SH3 and cysteine-rich domain-containing protein OS...	[more]
sp\|Q68F99\|STAC3_XENTR	7.162e-14	33.33	SH3 and cysteine-rich domain-containing protein 3 ...	[more]
sp\|Q96MF2\|STAC3_HUMAN	9.829e-14	34.78	SH3 and cysteine-rich domain-containing protein 3 ...	[more]
sp\|Q8BZ71\|STAC3_MOUSE	1.115e-13	34.78	SH3 and cysteine-rich domain-containing protein 3 ...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4Z2DES4	1.043e-46	30.77	Tyrosine-kinase Fes Fps-like isoform X5 OS=Schisto...	[more]
A0A183LF27	1.017e-44	28.42	Uncharacterized protein OS=Schistosoma margrebowie...	[more]
A0A3Q0KT18	6.432e-43	29.00	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
A0A1S3JKS6	1.321e-42	23.56	uncharacterized protein LOC106174122 isoform X5 OS...	[more]
A0A430QJV2	1.460e-40	27.17	Uncharacterized protein (Fragment) OS=Schistosoma ...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
STAC3	8.213e-16	31.65	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
STAC2	2.428e-13	42.35	SH3 and cysteine rich domain 2 [Source:HGNC Symbol...	[more]
grap2a	1.667e-9	48.28	GRB2-related adapter protein-like [Source:NCBI gen...	[more]
grap2a	1.667e-9	48.28	GRB2-related adapter protein-like [Source:NCBI gen...	[more]
grap2a	2.484e-9	49.02	GRB2-related adapter protein-like [Source:NCBI gen...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000009546.1	4.326e-14	38.89	pep scaffold:Pmarinus_7.0:GL485512:1487:9666:1 gen...	[more]
stac3	5.553e-13	36.67	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
stac	2.299e-11	31.03	SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-...	[more]
stam	1.253e-8	46.00	signal transducing adaptor molecule (SH3 domain an...	[more]
grb2a	2.963e-8	45.83	growth factor receptor-bound protein 2a [Source:ZF...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
PIN3	1.760e-9	35.96	Negative regulator of actin nucleation-promoting f...	[more]
LSB1	1.267e-8	48.08	Negative regulator of actin nucleation-promoting f...	[more]
YSC84	5.252e-8	48.08	Actin-binding protein; involved in bundling of act...	[more]
LSB3	7.174e-8	44.44	Protein containing a C-terminal SH3 domain; binds ...	[more]
HSE1	3.188e-7	41.18	Subunit of the endosomal Vps27p-Hse1p complex; com...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO36303	4.684e-15	22.15	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO50032	9.204e-7	44.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46357	1.462e-6	43.75	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38076	1.575e-6	42.31	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29864	1.648e-6	43.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
STAC2	2.143e-14	29.38	SH3 and cysteine-rich domain-containing protein 2 ...	[more]
STAC2	4.315e-13	35.34	SH3 and cysteine-rich domain-containing protein 2 ...	[more]
stac3	8.845e-13	32.17	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
stac3	1.377e-12	33.98	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]
stac3	2.188e-12	33.98	SH3 and cysteine rich domain 3 [Source:NCBI gene;A...	[more]

BLAST of Tyrosine-kinase Fes Fps-like isoform X5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000047737.1	0.000e+0	95.35	SMESG000047737.1	[more]
SMESG000039140.1	7.384e-50	34.47	SMESG000039140.1	[more]
SMESG000038704.1	2.199e-10	35.14	SMESG000038704.1	[more]
SMESG000073128.1	2.666e-6	39.62	SMESG000073128.1	[more]
SMESG000059156.1	8.449e-6	32.74	SMESG000059156.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30035381 ID=SMED30035381|Name=Tyrosine-kinase Fes Fps-like isoform X5|organism=Schmidtea mediterranea sexual|type=transcript|length=3201bp
CTGCCAACATCAAAAATTCACATCAACATTTTTTAGTTGTTTAATTGTAA
AAAAAATATAAGCTAACGTCGAATCAAGCCAAAAATAAATTGTCTGTCAA
TGTCAACTGTTTTCGATGAGTTCCTGTGTTGACCAATCAACTTGATCATT
TGATATAGATTTCAATTCCATTCCGTAAAATCGAATCAATTACATTCCAA
TCATTTATCGAAGAGAACTCAATTCCTATTTTTAACAAACAAATGGCAGC
CTGTGCTCACAACATGACCTATAGAGATCTGGCACATGCATCGTATCACG
GTGCTATACATCAAAAAATGCAGGAATCCATGAATATCATTGACAATGTT
AATCAATTATTAAAAGAAGTCAGTGAAACCTATGAAACATTTTGCGATAG
TTTGTCGTTAATATGTACAAAGTTCTCAAAGTCTTTAACAAGCTCAAATT
ATTCATCAGATTTTCTTGATTTGTGGAATTTATTATTACAATATTTTTCA
TCAGAAGCACAGATTTACCATGAATTCTGTGATGATTTTGACAGTCTCGT
GTGCAATCCTTTGCGAGCTATTTCAGCACATAAAAATAGTCAAAGAGAAA
AGCTTTATGAATTCAGATGCTCAGTGGAGAAAATGCTCAATGATCAATCA
GACACGATGGAACAATTGCATAGAGATTACATTGACCAGTACCAATTACA
GCGAGAAAAATATGATCCGAAACTCATTCCGGGATTATTAAATGCTCATA
ATAATTATGTATTGCAATTGGTTGCCAGTAATAAAATGAAGGATCAGTAT
CACAGTCAAGCTTTGCCAAGTGTCCTAGACGAACTAGAAACTATCCAAAG
AGAAATTATTCAAATATTCCATTCAAGTTTATGTCATTATTCAGGGGCGA
CAGCAAAAAAACACCGACAATTAATTGACTTTCAAGATCAGATACTCTCA
TCTATTAAAAGCCTTTCCCCAGATGACCAAATTATAAATTTTGTTCGTCA
ACTAAATACAAATCAAGCAGTATCATATTGGAGACGTGAGCAATTTTTGC
CTCCAGATGGTGACTGTCCAGAAATTCTTGCTAGAGATGATGTGATATCG
GACAAACTCACAGTGGAACCTCTTCAACATATTCGATCAGGTTTGTTAAA
AGAACAAAATGAACTTTTATCTTTCATTTCACAAAATGGTGATGTTATCA
GTACCCTAAAAGGTTTAAAAACGAACGGATTCTCCTACAGTCGGTCCTTT
GAAAAGTTATACGAATTGGATGATGATATCTGTAGGAAACAAAATGAAGT
TAGAATGGCTCAAGTGCAAGTTGCTGGTGTAATAGCTCAATTACAGCATA
TTGATAACAAGAAATTTTCGGGATTTGCTTTAAAAGACGAGGAAGACACG
GGCATGAAAAGAATATGGAAGAAAGCTGTGTTTTCCTTGAAGAGAGATAA
AGGCAGTAAAAATCAGAGTATTTTAAAGAATATCAAGAAAGAATCTTTTC
GTCCGGCCAGCAGTCCGTTACAAAACACTTTTCAAAATGATGATTCAAAA
GTCGACCCAGTTTATCATCTTCTTCGATGTGCAGCATCAAAAAGTCATTT
GTCAAGCTTTCAATGTGATTTGCGAGACTCGAATTCCAGTCCAACTCCCA
AATACAATGAAATGGCATTCCAAACTAGTAATGGACGTTTATCATTGATA
CAAACGGCATTTAACATGGCAAACCTAAGTAGGAGACGACTACTGCTTTG
CCAAACGAAGGCCAAGTCCTCTTCCGTTGAAGAAGGTGGTCAAGTTGGAG
ACGATAAAATCCTGAATTCGTCAAATTTGCATAGTCATTGGTTAGATACA
ATTAATACGGATTCCAGAGAGAACTCTCACAGGGGTTCCGTTTCGAAGCC
TAATAACTATATAAAATCTTCAATACCTATCAATAATCAAAAATGTGTTA
AAGGAAAATTGAAAACCATGTTTCATTCAGCTACTGTTTCACAACCTCCC
GATGAACAGTTGCTTGACAAAGGCATTTCTAAAAGTCCAGTATTCCATTC
TGATATTATGCACCGAAAACTTAATGAAAGAATGAAAAGTTTCTCGGTAG
ATAACCCTGACAAAGTCAGCAACACAGCAAGTTCGCCTCCTTCGATTTCT
CGGGACAATCGCAAGATGAGCAGTTCTTATACAAATACCAAATTATATGA
TTCCAATGTACCAATAAGTCCAAGGCGCAGAAAAACACTTTATGGAAGAA
AAAAAAGCTGTTCACTGGACCAAGAAAATCATGCGACAAGTCGCAGGGTC
GCATTTGCTGACGAAAGTATGACGCGGAAAGCTGATAGATCCTATGACAA
TTCTATATTTTTGGATCACAATGAAAAATCTTTTAAAACAAGCAATGAAA
TGATTTCTAAAAATCGAAGAAATTCAAGTCAGACGCGGCCGTTTTATAAT
TCATGGAGAGTTAAAAGTTTTTCACTTGACATGCCAGAGAAAGAAGAAAA
TAGTGAAAGCGAAATAAATCATCAAACATTTCCTACTAATTCTAATCTTT
TGACACCTACAACAGTCGGCACCACTGGTACTTTATCATATTCTCCAAAG
CATGATTCGAAAAGATTAGATCGTATATCTGAATCTCAAGAAAAAAGCCT
TTCAATGGAAATTGACAATCAAATCGAAGTCAACAATAAGAATAACCTGA
AAGTCCTAACCCATCAGAAAGAGCATATAGAAGAAAATATATCCAAACAA
TACACTAAAAAACTTGGCTATCGGTTGAGAGGAAATTTATACGTGGCATT
GTACGATTTCTGGTGTAGACAGAAAGATGAATTAAATTTGAGAGCCGGCT
GGAAAGTAAGTGCCATTGACATATCTGACGCAGACTGGTGGACAGGAAAG
TGTAACGGAAAATTCGGATATTTTCCTGCAAATTACGTTCAAGCCATTCA
CCAAGGAGAACATGTTTGGCGAGTCATTCGCGAAGTGTCTGTTGTCGATT
CGAATCAAACTCCAGTTAGGTTATATAAAAATCAAATCCTTGTACAAACT
GGTTCACAAGATGGCGATCAGATTCTTATTCGTACAAAGATAAACACAAC
ATTTTGGTGTCCTATTGATTGTGTTACAAAAGTGGTTGATAATTATTAAA
ATTTTGTTTTTATTTTTTTATTGAAAAATGTGCAGATGTTTGTAAAATTT
T

protein sequence of SMED30035381-orf-1

>SMED30035381-orf-1 ID=SMED30035381-orf-1|Name=SMED30035381-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=969bp
MAACAHNMTYRDLAHASYHGAIHQKMQESMNIIDNVNQLLKEVSETYETF
CDSLSLICTKFSKSLTSSNYSSDFLDLWNLLLQYFSSEAQIYHEFCDDFD
SLVCNPLRAISAHKNSQREKLYEFRCSVEKMLNDQSDTMEQLHRDYIDQY
QLQREKYDPKLIPGLLNAHNNYVLQLVASNKMKDQYHSQALPSVLDELET
IQREIIQIFHSSLCHYSGATAKKHRQLIDFQDQILSSIKSLSPDDQIINF
VRQLNTNQAVSYWRREQFLPPDGDCPEILARDDVISDKLTVEPLQHIRSG
LLKEQNELLSFISQNGDVISTLKGLKTNGFSYSRSFEKLYELDDDICRKQ
NEVRMAQVQVAGVIAQLQHIDNKKFSGFALKDEEDTGMKRIWKKAVFSLK
RDKGSKNQSILKNIKKESFRPASSPLQNTFQNDDSKVDPVYHLLRCAASK
SHLSSFQCDLRDSNSSPTPKYNEMAFQTSNGRLSLIQTAFNMANLSRRRL
LLCQTKAKSSSVEEGGQVGDDKILNSSNLHSHWLDTINTDSRENSHRGSV
SKPNNYIKSSIPINNQKCVKGKLKTMFHSATVSQPPDEQLLDKGISKSPV
FHSDIMHRKLNERMKSFSVDNPDKVSNTASSPPSISRDNRKMSSSYTNTK
LYDSNVPISPRRRKTLYGRKKSCSLDQENHATSRRVAFADESMTRKADRS
YDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEK
EENSESEINHQTFPTNSNLLTPTTVGTTGTLSYSPKHDSKRLDRISESQE
KSLSMEIDNQIEVNNKNNLKVLTHQKEHIEENISKQYTKKLGYRLRGNLY
VALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQ
AIHQGEHVWRVIREVSVVDSNQTPVRLYKNQILVQTGSQDGDQILIRTKI
NTTFWCPIDCVTKVVDNY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0016301	kinase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Vocabulary: **biological process**
Term	Definition
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0003104	enteric muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001452	SH3_domain

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular

Main menu

Tyrosine-kinase Fes Fps-like isoform X5

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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