Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035216 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CLK4 (CDC like kinase 4 [Source:HGNC Symbol;Acc:HGNC:13659]) HSP 1 Score: 195.667 bits (496), Expect = 1.293e-56 Identity = 129/358 (36.03%), Postives = 186/358 (51.96%), Query Frame = 1
Query: 223 QHREKKANKSNARNCKQVDSAPDI---GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
Q R K + +R+ + + I G V+ RY I LG+G+FG V C D + VA+K +K + + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF + + + Q+CQ++NF+H + HTDLKPENI+ Y Y+ + K + L+N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG I + +I + K+KYFH N A R C KPLK LC + E DL+ ML + RI EAL+H FF
Sbjct: 125 QSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH--GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTR---KRKYFHHNQLDWDEHSSAGRYVRRRC--KPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 475
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CLK2 (CDC like kinase 2 [Source:HGNC Symbol;Acc:HGNC:2069]) HSP 1 Score: 195.667 bits (496), Expect = 1.456e-56 Identity = 120/330 (36.36%), Postives = 180/330 (54.55%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG I +I + K+KYF++ +N + KPL+ EH DLIESML R+ EAL+H FF
Sbjct: 153 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 477
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CLK2 (CDC like kinase 2 [Source:HGNC Symbol;Acc:HGNC:2069]) HSP 1 Score: 195.667 bits (496), Expect = 1.456e-56 Identity = 120/330 (36.36%), Postives = 180/330 (54.55%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG I +I + K+KYF++ +N + KPL+ EH DLIESML R+ EAL+H FF
Sbjct: 153 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 477
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CLK2 (CDC like kinase 2 [Source:HGNC Symbol;Acc:HGNC:2069]) HSP 1 Score: 195.667 bits (496), Expect = 1.651e-56 Identity = 120/330 (36.36%), Postives = 180/330 (54.55%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG I +I + K+KYF++ +N + KPL+ EH DLIESML R+ EAL+H FF
Sbjct: 154 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CLK2 (CDC like kinase 2 [Source:HGNC Symbol;Acc:HGNC:2069]) HSP 1 Score: 195.667 bits (496), Expect = 1.651e-56 Identity = 120/330 (36.36%), Postives = 180/330 (54.55%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG I +I + K+KYF++ +N + KPL+ EH DLIESML R+ EAL+H FF
Sbjct: 154 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: madd-3 (Probable dual specificity protein kinase madd-3 [Source:UniProtKB/Swiss-Prot;Acc:G5EDB2]) HSP 1 Score: 186.037 bits (471), Expect = 1.402e-52 Identity = 121/328 (36.89%), Postives = 173/328 (52.74%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDV-------KPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G + R+ I LG+G+FG V D L+ +A+K +K + + E+ VLQ++A+ D + + I F + C++F + ++++FLK NHY P+ + + I Q+C AV F+H + HTDLKPENI+ D Y D+ + L + V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCILYEL TG T+F EHL ++E+ LG I R ++ K K+F NG L N D KPL+ C P+ +LIE+ML R+ EAL+HR+F
Sbjct: 250 GDFILNRFTIYDTLGEGTFGKVVRVNDSLSDTF-MALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFD--YNGHICLLFDLMGSSIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKPLRVLHSTHVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPL----RMAKRTKTKFF-INGRLDWVNTSADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF 569
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: madd-3 (Probable dual specificity protein kinase madd-3 [Source:UniProtKB/Swiss-Prot;Acc:G5EDB2]) HSP 1 Score: 185.652 bits (470), Expect = 1.661e-52 Identity = 120/328 (36.59%), Postives = 173/328 (52.74%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDV-------KPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G + R+ I LG+G+FG V D L+ +A+K +K + + E+ VLQ++A+ D + + I F + C++F + ++++FLK NHY P+ + + I Q+C AV F+H + HTDLKPENI+ D Y D+ + L + V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCILYEL TG T+F EHL ++E+ LG I + R + + K+F NG L N D KPL+ C P+ +LIE+ML R+ EAL+HR+F
Sbjct: 250 GDFILNRFTIYDTLGEGTFGKVVRVNDSLSDTF-MALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFD--YNGHICLLFDLMGSSIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKPLRVLHSTHVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKR-TNTFRTKFF-INGRLDWVNTSADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF 572
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: madd-3 (Probable dual specificity protein kinase madd-3 [Source:UniProtKB/Swiss-Prot;Acc:G5EDB2]) HSP 1 Score: 183.726 bits (465), Expect = 1.707e-50 Identity = 121/328 (36.89%), Postives = 174/328 (53.05%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDV-------KPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G + R+ I LG+G+FG V D L+ + +A+K +K + + E+ VLQ++A+ D + + I F + C++F + ++++FLK NHY P+ + + I Q+C AV F+H + HTDLKPENI+ D Y D+ + L + V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCILYEL TG T+F EHL ++E+ LG I R ++ K K+F NG L N D KPL+ C P+ +LIE+ML R+ EAL+HR+F
Sbjct: 544 GDFILNRFTIYDTLGEGTFGKVVRVNDSLS-DTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFD--YNGHICLLFDLMGSSIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKPLRVLHSTHVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPL----RMAKRTKTKFFI-NGRLDWVNTSADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF 863
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: madd-3 (Probable dual specificity protein kinase madd-3 [Source:UniProtKB/Swiss-Prot;Acc:G5EDB2]) HSP 1 Score: 183.341 bits (464), Expect = 2.290e-50 Identity = 120/328 (36.59%), Postives = 174/328 (53.05%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDV-------KPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G + R+ I LG+G+FG V D L+ + +A+K +K + + E+ VLQ++A+ D + + I F + C++F + ++++FLK NHY P+ + + I Q+C AV F+H + HTDLKPENI+ D Y D+ + L + V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCILYEL TG T+F EHL ++E+ LG I + R + + K+F NG L N D KPL+ C P+ +LIE+ML R+ EAL+HR+F
Sbjct: 544 GDFILNRFTIYDTLGEGTFGKVVRVNDSLS-DTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFD--YNGHICLLFDLMGSSIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKPLRVLHSTHVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKR-TNTFRTKFFI-NGRLDWVNTSADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF 866
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: madd-3 (Probable dual specificity protein kinase madd-3 [Source:UniProtKB/Swiss-Prot;Acc:G5EDB2]) HSP 1 Score: 159.844 bits (403), Expect = 1.220e-45 Identity = 98/242 (40.50%), Postives = 134/242 (55.37%), Query Frame = 1
Query: 550 CIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDV-------KPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
C++F + ++++FLK NHY P+ + + I Q+C AV F+H + HTDLKPENI+ D Y D+ + L + V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCILYEL TG T+F EHL ++E+ LG I + R + + K+F NG L N D KPL+ C P+ +LIE+ML R+ EAL+HR+F
Sbjct: 12 CLLFDLMGSSIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKPLRVLHSTHVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKR-TNTFRTKFF-INGRLDWVNTSADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF 251
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Doa (gene:FBgn0265998 transcript:FBtr0336461) HSP 1 Score: 182.956 bits (463), Expect = 4.527e-53 Identity = 123/332 (37.05%), Postives = 179/332 (53.92%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXR--SKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLKHLCKYPKFE---HALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY+I LG+G+FG V D+ + +A+K +K ++ + EI+ L++IA D C++ ID F CIVF M ++++FL+ N+Y P+ L + + + Q+C +V F+H + HTDLKPENI+ D Y Y+ + + ++++N V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCIL+EL G T+F + EHL ++E+ LG+I R + K KYF+ K+ A R HC KPL LC+ E LI+ ML RI EAL H FF
Sbjct: 44 GDILHHRYKIMATLGEGTFGRVVKVKDM-ERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFD--YHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPY----RMARKTKTKYFYHGKLDWDEKSSAGRYVRDHC--KPL-FLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF 365
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Doa (gene:FBgn0265998 transcript:FBtr0299748) HSP 1 Score: 184.882 bits (468), Expect = 1.209e-52 Identity = 123/333 (36.94%), Postives = 179/333 (53.75%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXR--SKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLKHLCKYPKFE---HALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY+I LG+G+FG V D+ + +A+K +K ++ + EI+ L++IA D C++ ID F CIVF M ++++FL+ N+Y P+ L + + + Q+C +V F+H + HTDLKPENI+ D Y Y+ + + ++++N V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCIL+EL G T+F + EHL ++E+ LG+I R + K KYF+ K+ A R HC KPL LC+ E LI+ ML RI EAL H FF
Sbjct: 156 TGDILHHRYKIMATLGEGTFGRVVKVKDM-ERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFD--YHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPY----RMARKTKTKYFYHGKLDWDEKSSAGRYVRDHC--KPL-FLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Doa (gene:FBgn0265998 transcript:FBtr0299752) HSP 1 Score: 184.882 bits (468), Expect = 1.209e-52 Identity = 123/333 (36.94%), Postives = 179/333 (53.75%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXR--SKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLKHLCKYPKFE---HALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY+I LG+G+FG V D+ + +A+K +K ++ + EI+ L++IA D C++ ID F CIVF M ++++FL+ N+Y P+ L + + + Q+C +V F+H + HTDLKPENI+ D Y Y+ + + ++++N V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCIL+EL G T+F + EHL ++E+ LG+I R + K KYF+ K+ A R HC KPL LC+ E LI+ ML RI EAL H FF
Sbjct: 156 TGDILHHRYKIMATLGEGTFGRVVKVKDM-ERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFD--YHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPY----RMARKTKTKYFYHGKLDWDEKSSAGRYVRDHC--KPL-FLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Doa (gene:FBgn0265998 transcript:FBtr0299745) HSP 1 Score: 184.882 bits (468), Expect = 3.460e-52 Identity = 123/333 (36.94%), Postives = 179/333 (53.75%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXR--SKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLKHLCKYPKFE---HALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY+I LG+G+FG V D+ + +A+K +K ++ + EI+ L++IA D C++ ID F CIVF M ++++FL+ N+Y P+ L + + + Q+C +V F+H + HTDLKPENI+ D Y Y+ + + ++++N V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCIL+EL G T+F + EHL ++E+ LG+I R + K KYF+ K+ A R HC KPL LC+ E LI+ ML RI EAL H FF
Sbjct: 225 TGDILHHRYKIMATLGEGTFGRVVKVKDM-ERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFD--YHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPY----RMARKTKTKYFYHGKLDWDEKSSAGRYVRDHC--KPL-FLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF 547
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Doa (gene:FBgn0265998 transcript:FBtr0299742) HSP 1 Score: 184.882 bits (468), Expect = 3.460e-52 Identity = 123/333 (36.94%), Postives = 179/333 (53.75%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXR--SKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLKHLCKYPKFE---HALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY+I LG+G+FG V D+ + +A+K +K ++ + EI+ L++IA D C++ ID F CIVF M ++++FL+ N+Y P+ L + + + Q+C +V F+H + HTDLKPENI+ D Y Y+ + + ++++N V++IDFG A + HS TRHYRAPEVILE WS D+WSIGCIL+EL G T+F + EHL ++E+ LG+I R + K KYF+ K+ A R HC KPL LC+ E LI+ ML RI EAL H FF
Sbjct: 225 TGDILHHRYKIMATLGEGTFGRVVKVKDM-ERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFD--YHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPY----RMARKTKTKYFYHGKLDWDEKSSAGRYVRDHC--KPL-FLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF 547
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: clk4b (CDC-like kinase 4b [Source:ZFIN;Acc:ZDB-GENE-050227-19]) HSP 1 Score: 192.2 bits (487), Expect = 1.156e-55 Identity = 124/331 (37.46%), Postives = 183/331 (55.29%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKHL--CKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY I LG+G+FG V C D N+ VA+K +K I+ + ++E+ VL+RI D + C++ +D F CIVF + + Y+FLK N +MPF+L + + + Q+ +AV F+H + HTDLKPENI+ D +YD Y+ R K + L+ L VKV+DFG A + H+ TRHYRAPEVILE W+ D+WS+GCIL E G T+F ++ EHL ++E+ LG I ++ + K++Y H + A R HC KPLK K P+ E DL++ M+ + RI +A+ H FF
Sbjct: 148 GDMLRARYEIVGTLGEGAFGKVVECLDHTKGNVRVALKIIKNIERYREAALSEVDVLERINSLDDEKRFACVRMLDWFDH--HGHICIVFELLGLSTYDFLKENGFMPFSLTQIRHMADQIFRAVRFLHKNKLTHTDLKPENILFVDSNYDIKYNSRMKRDERTLKRLDVKVVDFGNATYDHEHHTSVVSTRHYRAPEVILELGWNQACDVWSLGCILVEFYLGLTLFQTHDSKEHLAMMEKVLGPIPTHLLQKTK---KRRYVHHDKLDWDEHSSAGRYVRKHC--KPLKQYMSSKTPEHELLFDLLQKMMEYDSSKRITLEQAIGHPFF 471
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: clk2a (CDC-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-298]) HSP 1 Score: 193.356 bits (490), Expect = 1.388e-55 Identity = 120/329 (36.47%), Postives = 181/329 (55.02%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+++RY I LG+G+FG V C D VA+K +K ++ + EI+VL+RI + D + ++ C+Q D F CI F + + + ++FLK N+Y+P+++++ + + QVC AV F+H + HTDLKPENI+ + Y Y+ K + ++N V+V+DFG A + HS TRHYRAPEVILE WS D+WSIG IL+E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL+ EH DLIE+ML R+ + ALRH FF
Sbjct: 180 GDVLQERYEIVSTLGEGTFGRVMQCIDHRRGGAHVALKIIKNVEKYKEAARLEINVLERINEKDPENNNLCVQMFDWFD--YHGHMCISFELLALSTFDFLKENNYLPYSINQVRHMAYQVCLAVKFLHENKLTHTDLKPENILFVNSDYTVTYNVEKKRDERTVKNTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGSILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENSSAGRYVRENCKPLRRYLLSEAEEHHQLFDLIEAMLEYEPSKRLTLAAALRHPFF 503
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: clk2a (CDC-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-298]) HSP 1 Score: 193.356 bits (490), Expect = 1.415e-55 Identity = 120/329 (36.47%), Postives = 181/329 (55.02%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+++RY I LG+G+FG V C D VA+K +K ++ + EI+VL+RI + D + ++ C+Q D F CI F + + + ++FLK N+Y+P+++++ + + QVC AV F+H + HTDLKPENI+ + Y Y+ K + ++N V+V+DFG A + HS TRHYRAPEVILE WS D+WSIG IL+E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL+ EH DLIE+ML R+ + ALRH FF
Sbjct: 181 GDVLQERYEIVSTLGEGTFGRVMQCIDHRRGGAHVALKIIKNVEKYKEAARLEINVLERINEKDPENNNLCVQMFDWFD--YHGHMCISFELLALSTFDFLKENNYLPYSINQVRHMAYQVCLAVKFLHENKLTHTDLKPENILFVNSDYTVTYNVEKKRDERTVKNTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGSILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENSSAGRYVRENCKPLRRYLLSEAEEHHQLFDLIEAMLEYEPSKRLTLAAALRHPFF 504
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: clk2b (CDC-like kinase 2b [Source:ZFIN;Acc:ZDB-GENE-060929-1126]) HSP 1 Score: 185.267 bits (469), Expect = 9.257e-53 Identity = 112/330 (33.94%), Postives = 177/330 (53.64%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC-------DVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V++ RY I + LG+G+FG V C D +A+K +K ++ + EI+VL++I D + + C+Q +D F C+ F + + ++F+K N+Y+P+++ + + + Q+C AV F+H + HTDLKPENI+ Y Y+ K + + + V+++DFG A + HS TRHYRAPEVILE WS D+WSIGCIL+E G T++ + EHL ++E+ G + +I + K+KYF++ G L D + +PL+ LC+ DL+E +L R+ S ALRH FF
Sbjct: 158 GDVLQDRYEITQTLGEGTFGKVVECVDHQRGGSRIALKIIKNVEKYKEAARLEINVLEKINQRDPENKNLCVQMLDWFD--YHGHMCLSFELLGLSTFDFMKENNYLPYSISQVRHMAYQICLAVKFLHDNKLTHTDLKPENILFVSSDYSVLYNAEKKRDERSVNSTAVRIVDFGSATFDHEHHSSIVSTRHYRAPEVILELGWSQPCDVWSIGCILFEFYCGYTLYQTHDNREHLAMMERIHGPVPSRMIRKTR---KQKYFYR-GRLDWDESTSAGRYVRENCRPLRRYMLCESEDHHQFFDLLEGLLEYEPEQRLSLSAALRHPFF 481
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: clk4a (CDC-like kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030131-576]) HSP 1 Score: 176.022 bits (445), Expect = 2.106e-49 Identity = 113/330 (34.24%), Postives = 172/330 (52.12%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCK---------YPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY I LG+G+FG V C D +A+K +K I+ ++E+ VL++I D C++ D F CI F + + Y+FLK N++ PF ++ + + Q+ +AV F+H + HTDLKPENI+ + Y+ Y+ + K + ++N VKV+DFG A E H+ TRHYRAPEVIL+ WS D+WS+GCIL E G T+F ++ EHL ++E+ LG I ++ + +K F +N L D + ++ CK E DLIE ML ++ RI EA++H FF
Sbjct: 165 GDMLRARYEIVCTLGEGAFGKVVECIDHEKVGARIALKIIKNIERYRDAALSEVEVLEQINSLDCDRRYACVRMYDWFDHH--GHICIAFELLGLSTYDFLKENNFQPFYINHIRHMAYQIIRAVRFLHKNKLTHTDLKPENILFVNSEYNIRYNSKMKRDERTVKNPDVKVVDFGNATYEHEHHTSVVSTRHYRAPEVILDLGWSHSCDVWSVGCILIEYYLGSTLFQTHDSKEHLAMMERVLGPIPTHML----QKTRKSRFVRNDKLDWDIHSSSGRYVRKQCKPLRQYLVSSSSDHEQLFDLIERMLEYDVTKRITLDEAIKHPFF 488
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dkk3 (dickkopf WNT signaling pathway inhibitor 3 [Source:Xenbase;Acc:XB-GENE-877183]) HSP 1 Score: 188.734 bits (478), Expect = 4.270e-55 Identity = 127/358 (35.47%), Postives = 188/358 (52.51%), Query Frame = 1
Query: 220 KQHREKKANKSNARNCKQVDSAPDI----GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLK-HLCKYPKFEHAL-DLIESMLNVNLRHRIGSSEALRHRFF 1245
K HR+K++ +VD + G V+ +RY I LG+G+FG V C D L VA+K +K ++ + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF L + + Q+C+++NF+H + HTDLKPENI+ Y ++ + + L+N +K++DFG A HS TRHYRAPEVILE WS D+WSIGCIL E G T+F ++ EHL ++E+ LG + +I + K KYF+ + A R C KPLK ++ K H L DLI+ ML + RI EAL+H FF
Sbjct: 27 KSHRKKRSRSV------EVDEEGHLICESGDVLRERYEIVHALGEGAFGKVLECIDHLRGGERVAVKIIKNVERYREAAQSEIQVLEHLNRKDPINTFRCVQMLEWFDHH--GHICIVFELLGLSTYDFIKENSFLPFPLDHIRNMAYQICKSINFLHQNQLTHTDLKPENILFVHSDYVVHFNHKQDERYLKNSDIKIVDFGSATYNDEYHSALVSTRHYRAPEVILELGWSQPCDVWSIGCILIEYYLGLTVFQTHDSKEHLAMMERILGPLPLHMIKKTR---KHKYFYLDRLDWDEHSSAGRYVKKRC--KPLKEYMVSDNKDHHQLFDLIQRMLEYDPAKRITLEEALKHPFF 371
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ezr (ezrin [Source:Xenbase;Acc:XB-GENE-484766]) HSP 1 Score: 188.348 bits (477), Expect = 9.438e-54 Identity = 122/347 (35.16%), Postives = 187/347 (53.89%), Query Frame = 1
Query: 244 NKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKK--LRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLC----KYPKFEHA-----LDLIESMLNVNLRHRIGSSEALRHRFF 1245
+ N N K+ G +++RY I LGKG+FG V C DL N VA+K ++ + + EI+VL++I + D+ + C+ D F CI F + + +EF K N+++P+ L + + Q+CQA+ F+H + HTDLKPENI+ + YD CY++ K ++ ++N +++++DFG A + H+ TRHYR PEVILE WS D+WS+GCIL+E TG T+F + EHL ++E+ LG + R ++ + K+KYFH NG+L D D + + C Y + A DL+ ML RI EAL H+FF
Sbjct: 138 DSQNVENDKEGHLVCRTGERIQERYEIVGDLGKGTFGKVVECLDLARGNSRVALKIIRNVRKYREAAQLEINVLEKIKERDQDNKNMCVLMRDWFD--FHGHVCIAFELLGKSTFEFQKENNFLPYPLAHIRHMAFQLCQALKFLHENQLTHTDLKPENILFVNSEYDICYNESKKCEEKCVKNPSIRIVDFGSATFDHEYHTTIVATRHYRPPEVILELGWSQPCDVWSLGCILFEYYTGFTLFQTHDNREHLVMMEKILGPLPRRMVYKTR---KQKYFH-NGSLIWDENSSDGRYVSKNCHQLMSYKSSDSAEHVQLFDLLSRMLEFRPALRITLQEALEHQFF 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ezr (ezrin [Source:Xenbase;Acc:XB-GENE-484766]) HSP 1 Score: 187.963 bits (476), Expect = 1.075e-53 Identity = 122/347 (35.16%), Postives = 187/347 (53.89%), Query Frame = 1
Query: 244 NKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKK--LRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLC----KYPKFEHA-----LDLIESMLNVNLRHRIGSSEALRHRFF 1245
+ N N K+ G +++RY I LGKG+FG V C DL N VA+K ++ + + EI+VL++I + D+ + C+ D F CI F + + +EF K N+++P+ L + + Q+CQA+ F+H + HTDLKPENI+ + YD CY++ K ++ ++N +++++DFG A + H+ TRHYR PEVILE WS D+WS+GCIL+E TG T+F + EHL ++E+ LG + R ++ + K+KYFH NG+L D D + + C Y + A DL+ ML RI EAL H+FF
Sbjct: 133 DSQNVENDKEGHLVCRTGERIQERYEIVGDLGKGTFGKVVECLDLARGNSRVALKIIRNVRKYREAAQLEINVLEKIKERDQDNKNMCVLMRDWFD--FHGHVCIAFELLGKSTFEFQKENNFLPYPLAHIRHMAFQLCQALKFLHENQLTHTDLKPENILFVNSEYDICYNESKKCEEKCVKNPSIRIVDFGSATFDHEYHTTIVATRHYRPPEVILELGWSQPCDVWSLGCILFEYYTGFTLFQTHDNREHLVMMEKILGPLPRRMVYKTR---KQKYFH-NGSLIWDENSSDGRYVSKNCHQLMSYKSSDSAEHVQLFDLLSRMLEFRPALRITLQEALEHQFF 473
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dkk3 (dickkopf WNT signaling pathway inhibitor 3 [Source:Xenbase;Acc:XB-GENE-877183]) HSP 1 Score: 187.578 bits (475), Expect = 1.288e-53 Identity = 130/364 (35.71%), Postives = 190/364 (52.20%), Query Frame = 1
Query: 208 TRALKQHREKKANKSNARNCKQVDSAPDI----GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSK--FKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLK-HLCKYPKFEHAL-DLIESMLNVNLRHRIGSSEALRHRFF 1245
T LK HR+K++ +VD + G V+ +RY I LG+G+FG V C D L VA+K +K ++ + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF L + + Q+C+++NF+H + HTDLKPENI+ Y ++ K + L+N +K++DFG A HS TRHYRAPEVILE WS D+WSIGCIL E G T+F ++ EHL ++E+ LG + +I + K KYF+ + A R C KPLK ++ K H L DLI+ ML + RI EAL+H FF
Sbjct: 126 TSHLKSHRKKRSRSV------EVDEEGHLICESGDVLRERYEIVHALGEGAFGKVLECIDHLRGGERVAVKIIKNVERYREAAQSEIQVLEHLNRKDPINTFRCVQMLEWFDHH--GHICIVFELLGLSTYDFIKENSFLPFPLDHIRNMAYQICKSINFLHQNQLTHTDLKPENILFVHSDYVVHFNHAKKQDERYLKNSDIKIVDFGSATYNDEYHSALVSTRHYRAPEVILELGWSQPCDVWSIGCILIEYYLGLTVFQTHDSKEHLAMMERILGPLPLHMIKKTR---KHKYFYLDRLDWDEHSSAGRYVKKRC--KPLKEYMVSDNKDHHQLFDLIQRMLEYDPAKRITLEEALKHPFF 476
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dkk3 (dickkopf WNT signaling pathway inhibitor 3 [Source:Xenbase;Acc:XB-GENE-877183]) HSP 1 Score: 184.496 bits (467), Expect = 1.375e-53 Identity = 128/360 (35.56%), Postives = 188/360 (52.22%), Query Frame = 1
Query: 220 KQHREKKANKSNARNCKQVDSAPDI----GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSK--FKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLK-HLCKYPKFEHAL-DLIESMLNVNLRHRIGSSEALRHRFF 1245
K HR+K++ +VD + G V+ +RY I LG+G+FG V C D L VA+K +K ++ + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF L + + Q+C+++NF+H + HTDLKPENI+ Y ++ K + L+N +K++DFG A HS TRHYRAPEVILE WS D+WSIGCIL E G T+F ++ EHL ++E+ LG + +I + K KYF+ + A R C KPLK ++ K H L DLI+ ML + RI EAL+H FF
Sbjct: 27 KSHRKKRSRSV------EVDEEGHLICESGDVLRERYEIVHALGEGAFGKVLECIDHLRGGERVAVKIIKNVERYREAAQSEIQVLEHLNRKDPINTFRCVQMLEWFDHH--GHICIVFELLGLSTYDFIKENSFLPFPLDHIRNMAYQICKSINFLHQNQLTHTDLKPENILFVHSDYVVHFNHAKKQDERYLKNSDIKIVDFGSATYNDEYHSALVSTRHYRAPEVILELGWSQPCDVWSIGCILIEYYLGLTVFQTHDSKEHLAMMERILGPLPLHMIKKTR---KHKYFYLDRLDWDEHSSAGRYVKKRC--KPLKEYMVSDNKDHHQLFDLIQRMLEYDPAKRITLEEALKHPFF 373
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Clk4 (CDC like kinase 4 [Source:MGI Symbol;Acc:MGI:1098551]) HSP 1 Score: 194.897 bits (494), Expect = 1.662e-56 Identity = 125/331 (37.76%), Postives = 175/331 (52.87%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+ RY I LG+G+FG V C D L VA+K +K + + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF + + + Q+CQ++NF+H + HTDLKPENI+ Y Y+ + K + L+N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG I +I + K+KYFH N A R C KPLK LC + E DL+ ML + RI EAL+H FF
Sbjct: 152 GDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH--GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTR---KRKYFHHNQLDWDEHSSAGRYVRRRC--KPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFF 475
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Clk1 (CDC-like kinase 1 [Source:MGI Symbol;Acc:MGI:107403]) HSP 1 Score: 194.512 bits (493), Expect = 2.161e-56 Identity = 124/331 (37.46%), Postives = 178/331 (53.78%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDD-QRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKHLCKYPKFEHAL--DLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+ RY I LG+G+FG V C D VA+K +K +D + +EI VL+ + D ++ C+Q ++ F R CIVF + + Y+F+K N ++PF + + + Q+C++VNF+HS + HTDLKPENI+ Y Y+ + K + + N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG + + +I + K++YFH + A R + C KPLK EH L DLI ML + RI EAL+H FF
Sbjct: 153 GDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHR--GHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTR---KRRYFHHDRLDWDEHSSAGRYVSRRC--KPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF 476
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Clk2 (CDC-like kinase 2 [Source:MGI Symbol;Acc:MGI:1098669]) HSP 1 Score: 193.356 bits (490), Expect = 8.841e-56 Identity = 119/330 (36.06%), Postives = 183/330 (55.45%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPL-KHLCKYPKFEHAL-DLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL ++L + H L DLIE+ML R+ EAL+H FF
Sbjct: 154 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFF 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Clk2 (CDC-like kinase 2 [Source:MGI Symbol;Acc:MGI:1098669]) HSP 1 Score: 193.356 bits (490), Expect = 9.024e-56 Identity = 119/330 (36.06%), Postives = 183/330 (55.45%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPL-KHLCKYPKFEHAL-DLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL ++L + H L DLIE+ML R+ EAL+H FF
Sbjct: 155 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFF 479
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Clk2 (CDC-like kinase 2 [Source:MGI Symbol;Acc:MGI:1098669]) HSP 1 Score: 193.356 bits (490), Expect = 9.031e-56 Identity = 119/330 (36.06%), Postives = 183/330 (55.45%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPL-KHLCKYPKFEHAL-DLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL ++L + H L DLIE+ML R+ EAL+H FF
Sbjct: 153 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFF 477
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9HAZ1|CLK4_HUMAN (Dual specificity protein kinase CLK4 OS=Homo sapiens OX=9606 GN=CLK4 PE=1 SV=1) HSP 1 Score: 195.667 bits (496), Expect = 6.209e-56 Identity = 129/358 (36.03%), Postives = 186/358 (51.96%), Query Frame = 1
Query: 223 QHREKKANKSNARNCKQVDSAPDI---GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
Q R K + +R+ + + I G V+ RY I LG+G+FG V C D + VA+K +K + + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF + + + Q+CQ++NF+H + HTDLKPENI+ Y Y+ + K + L+N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG I + +I + K+KYFH N A R C KPLK LC + E DL+ ML + RI EAL+H FF
Sbjct: 125 QSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH--GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTR---KRKYFHHNQLDWDEHSSAGRYVRRRC--KPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 475
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P49760|CLK2_HUMAN (Dual specificity protein kinase CLK2 OS=Homo sapiens OX=9606 GN=CLK2 PE=1 SV=1) HSP 1 Score: 195.667 bits (496), Expect = 8.093e-56 Identity = 120/330 (36.36%), Postives = 180/330 (54.55%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+G +++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ +H+ + + Q+CQAV F+H + HTDLKPENI+ + Y+ Y+ K + +++ V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCI++E G T+F + EHL ++E+ LG I +I + K+KYF++ +N + KPL+ EH DLIESML R+ EAL+H FF
Sbjct: 155 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD--YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTR---KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 479
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O35493|CLK4_MOUSE (Dual specificity protein kinase CLK4 OS=Mus musculus OX=10090 GN=Clk4 PE=1 SV=1) HSP 1 Score: 194.897 bits (494), Expect = 1.163e-55 Identity = 125/331 (37.76%), Postives = 175/331 (52.87%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+ RY I LG+G+FG V C D L VA+K +K + + +EI VL+ + D + C+Q ++ F CIVF + + Y+F+K N ++PF + + + Q+CQ++NF+H + HTDLKPENI+ Y Y+ + K + L+N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG I +I + K+KYFH N A R C KPLK LC + E DL+ ML + RI EAL+H FF
Sbjct: 152 GDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH--GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTR---KRKYFHHNQLDWDEHSSAGRYVRRRC--KPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFF 475
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P22518|CLK1_MOUSE (Dual specificity protein kinase CLK1 OS=Mus musculus OX=10090 GN=Clk1 PE=1 SV=2) HSP 1 Score: 194.512 bits (493), Expect = 1.511e-55 Identity = 124/331 (37.46%), Postives = 178/331 (53.78%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDD-QRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKHLCKYPKFEHAL--DLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+ RY I LG+G+FG V C D VA+K +K +D + +EI VL+ + D ++ C+Q ++ F R CIVF + + Y+F+K N ++PF + + + Q+C++VNF+HS + HTDLKPENI+ Y Y+ + K + + N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG + + +I + K++YFH + A R + C KPLK EH L DLI ML + RI EAL+H FF
Sbjct: 153 GDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHR--GHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTR---KRRYFHHDRLDWDEHSSAGRYVSRRC--KPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF 476
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P49759|CLK1_HUMAN (Dual specificity protein kinase CLK1 OS=Homo sapiens OX=9606 GN=CLK1 PE=1 SV=2) HSP 1 Score: 194.512 bits (493), Expect = 1.528e-55 Identity = 126/331 (38.07%), Postives = 178/331 (53.78%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDD-QRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKHLCKYPKFEHA--LDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+ RY I LG+G+FG V C D A VA+K +K +D + +EI VL+ + D ++ C+Q ++ F CIVF + + Y+F+K N ++PF L + + Q+C++VNF+HS + HTDLKPENI+ Y Y+ + K + L N +KV+DFG A + HS TRHYRAPEVIL WS D+WSIGCIL E G T+F ++ EHL ++E+ LG + + +I + K+KYFH + A R + C KPLK EH DLI+ ML + RI EAL+H FF
Sbjct: 154 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHH--GHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTR---KRKYFHHDRLDWDEHSSAGRYVSRRC--KPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A3S5FEU3 (Protein kinase domain-containing protein (Fragment) OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS20974 PE=3 SV=1) HSP 1 Score: 224.172 bits (570), Expect = 2.476e-65 Identity = 147/364 (40.38%), Postives = 215/364 (59.07%), Query Frame = 1
Query: 211 RALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQ-RTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXR--SKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVI--DRCSEAIKKKYFHKNGALRKDNFHCD-------VKPLKHLC-----KYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFFL 1248
R +++ R K+++ + R K++ P IG +++RY + K LG+GSFG V C DL L VA+K LK +DD + +E+ VL +A DK SS+CI +D F R S I FP+ ++++FL+ N Y P+ + + +I Q+C AVNF+HS + HTD+KPENI+ +D+YD Y D+ + +R+ T+KVIDFG A + H QTRHYRAPEV+LE WSF D+WSIGCI+YEL+TG+ +FM + +HL ++E+FLG + R++I RC ++YFHK L D D VKPL + Y + + DLI+ ML + RI +S+AL H F L
Sbjct: 41 RLVERDRRKESHAKHWR--KELAVVP-IGDTIKRRYEVRKILGEGSFGQVLDCIDLHTQKL-VAVKVLKRLDDHKVAAAHELEVLVNLAKLDKTGSSNCINVLDFFDWRGSY--FISFPLLGSSVFQFLEANEYAPYPIEQVASISAQLCDAVNFMHSCRLAHTDIKPENILFVNDAYDEIYDDKLGRPLRVVRDSTIKVIDFGSATYDNEHHPTIIQTRHYRAPEVVLELGWSFPADVWSIGCIIYELVTGDCLFMTHDNLQHLAMMERFLGPLPRNMIRKSRC-----RRYFHK-CKLDWDPEGSDGCYVRKHVKPLADIWFASSDMYKRL--SFDLIKEMLYFDPHQRITASKALEHPFTL 390
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A5K3EG97 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 217.238 bits (552), Expect = 3.532e-61 Identity = 147/422 (34.83%), Postives = 223/422 (52.84%), Query Frame = 1
Query: 43 NF*KISTMKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTM-NEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRS--KFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVI--------------DRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPK---FEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+F K S KRK DSS ++S P K + Q R+ ++ + K++++ + R+ Q + +G V+++R+ + K LG+GSFG V C DL + VA+K LK ++D Q +E+ VL I+ AD+ S+CI+ ID F IVFP+ S +++ L++N Y P+ + A I Q+C+AV F+H + I HTDLKPENIM ++ Y+++ + R+ +VKVIDFG AV EG H QTRHYRAPEV+LE WS+ D+WSIGCILYEL+TG+ +FM + EHL ++E+FLG + + ++ D +++ +Y ++ VKPL +L A DL+ +L + RI S EAL H F
Sbjct: 149 DFSKSSVYKRKHGDSSHRSTSH----------PSHKRKRQ---------------RRSKERAKRKESHEHHKRDKTQ--AVVPVGEVIKRRFEVRKVLGEGSFGQVLECLDLHTQS-RVAVKALKRLEDYQEAAKHEVDVLDAISKADRSLRSNCIETIDFFE--WHRHYYIVFPLLSASVFNLLEQNDYEPYPIEHAIAITQQLCEAVTFMHKMRICHTDLKPENIMFVSPDFNEIYNEKRGRTIRVARDPSVKVIDFGSAVTEGERHPTTIQTRHYRAPEVVLECGWSYSADVWSIGCILYELVTGQCLFMTHDNLEHLAMMERFLGPLPKHMVRSSRKRRYFRRGRLDWDADSADGRYVRRH-----------VKPLGNLWLSTDDLTTRLAFDLVRELLTYDPDVRISSREALEHPLF 529
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A074ZG40 (Kinase domain protein OS=Opisthorchis viverrini OX=6198 GN=T265_07764 PE=4 SV=1) HSP 1 Score: 217.624 bits (553), Expect = 4.036e-61 Identity = 134/359 (37.33%), Postives = 209/359 (58.22%), Query Frame = 1
Query: 211 RALKQHREKKANKSNARNCKQVDSAP--DIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRS--KFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFEH-------ALDLIESMLNVNLRHRIGSSEALRHRFFL 1248
R ++ R+++A + + + +P +G V+++RYR+EK +G+GS+G V C D+ +L A+K LK DD +E+ V++ I+ +D + SHCI +D F N +VFP+ +++ FL++N+Y P+ + + +I+ Q+C+AV+F+H++ I HTDLKPENI+ D SYD YS + K +++RN +V++IDFG A +G HS QTRHYRAPEV+++ W D+WSIGCIL+EL+TG+ +FM + EHL ++E+ LG I RS+I ++ + + K LK L +Y F H A DL+ ML RI S AL H F L
Sbjct: 193 RKAQKRRDERAQRKLSHEGHKRKPSPVVTVGDVIKRRYRVEKIIGEGSYGQVFECFDMCTNSL-AAVKALKPQDDYKDAAKHELQVIESISRSDSRNRSHCITSLDFFD--WHNHFFLVFPLLGPSVFSFLEQNNYEPYPVEHSASILRQLCEAVHFLHNIGITHTDLKPENILFVDGSYDEVYSSQRNRKVRRIRNASVRLIDFGSATFDGDHHSTTIQTRHYRAPEVVMDLGWDVSADIWSIGCILFELVTGQCLFMTHDNLEHLAMMERVLGPIPRSMIKASRRRRYFRHGRLDWPDDSSDARHVRKMLKPLGEY-WFSHSDMYTRLAFDLVREMLVYIPSSRITCSRALEHPFML 547
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0R3UEC4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS5336 PE=4 SV=1) HSP 1 Score: 216.853 bits (551), Expect = 5.077e-61 Identity = 147/422 (34.83%), Postives = 223/422 (52.84%), Query Frame = 1
Query: 43 NF*KISTMKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTM-NEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRS--KFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVI--------------DRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPK---FEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+F K S KRK DSS ++S P K + Q R+ ++ + K++++ + R+ Q + +G V+++R+ + K LG+GSFG V C DL + VA+K LK ++D Q +E+ VL I+ AD+ S+CI+ ID F IVFP+ S +++ L++N Y P+ + A I Q+C+AV F+H + I HTDLKPENIM ++ Y+++ + R+ +VKVIDFG AV EG H QTRHYRAPEV+LE WS+ D+WSIGCILYEL+TG+ +FM + EHL ++E+FLG + + ++ D +++ +Y ++ VKPL +L A DL+ +L + RI S EAL H F
Sbjct: 161 DFSKSSVYKRKHGDSSHRSTSH----------PSHKRKRQ---------------RRSKERAKRKESHEHHKRDKTQ--AVVPVGEVIKRRFEVRKVLGEGSFGQVLECLDLHTQS-RVAVKALKRLEDYQEAAKHEVDVLDAISKADRSLRSNCIETIDFFE--WHRHYYIVFPLLSASVFNLLEQNDYEPYPIEHAIAITQQLCEAVTFMHKMRICHTDLKPENIMFVSPDFNEIYNEKRGRTIRVARDPSVKVIDFGSAVTEGERHPTTIQTRHYRAPEVVLECGWSYSADVWSIGCILYELVTGQCLFMTHDNLEHLAMMERFLGPLPKHMVRSSRKRRYFRRGRLDWDADSADGRYVRRH-----------VKPLGNLWLSTDDLTTRLAFDLVRELLTYDPDVRISSREALEHPLF 541
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: H2KVB8 (Dual specificity protein kinase CLK2 OS=Clonorchis sinensis OX=79923 GN=CLF_111818 PE=4 SV=1) HSP 1 Score: 217.238 bits (552), Expect = 5.245e-61 Identity = 134/359 (37.33%), Postives = 209/359 (58.22%), Query Frame = 1
Query: 211 RALKQHREKKANKSNARNCKQVDSAP--DIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRS--KFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFEH-------ALDLIESMLNVNLRHRIGSSEALRHRFFL 1248
R ++ R+++A + + + +P +G V+++RYR+EK +G+GS+G V C D+ +L A+K LK DD +E+ V++ I+ +D + SHCI +D F N +VFP+ +++ FL++N+Y P+ + + +I+ Q+C+AV+F+HS+ I HTDLKPENI+ D SYD YS + K +++RN +V++IDFG A +G HS QTRHYRAPEV+++ W D+WSIGCIL+EL+TG+ +FM + EHL ++E+ LG I RS+I ++ + + K LK L +Y F H A DL+ ML RI + AL H F L
Sbjct: 193 RKAQKRRDERAQRKLSHEGHKRKPSPVVTVGDVIKRRYRVEKIIGEGSYGQVFECFDVCTNSL-AAVKALKPQDDYKDAAKHELQVIESISRSDSRNRSHCITSLDFFD--WHNHFFLVFPLLGPSVFSFLEQNNYEPYPVEHSASILRQLCEAVHFLHSIGITHTDLKPENILFVDGSYDEVYSSQRNRKVRRIRNASVRLIDFGSATFDGDRHSTTIQTRHYRAPEVVMDLGWDVSADIWSIGCILFELVTGQCLFMTHDNLEHLAMMERVLGPIPRSMIKASRRRRYFRHGRLDWPDDSSDARHVRKMLKPLGEY-WFSHSDMYTRLAFDLVREMLVYIPSSRITCNRALEHPFML 547
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: clk4a (dual specificity protein kinase CLK4-like [Source:NCBI gene;Acc:103029292]) HSP 1 Score: 192.971 bits (489), Expect = 7.176e-56 Identity = 124/331 (37.46%), Postives = 179/331 (54.08%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKN--------GALRKDNFHCDVKPLKHLCKYPKFEHA--LDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY I LG+G+FG V C D N VA+K +K ID + M+E+ VL+++ D C++ +D F CI F + + ++FLK N++ PF + + + + Q+ +AV F+H + HTDLKPENI+ D YD Y+ + K + +RN VKV+DFG A E H+ TRHYRAPEVILE WS D+WSIGCIL E G T+F ++ EHL ++E+ LG I ++ + K++Y H + + R HC KPL+ K +H DLIE ML ++ RI EA+RH FF
Sbjct: 160 GDILRARYEIVCTLGEGAFGKVVECIDRSNRNARVALKIIKNIDRYREAAMSEVEVLEQMNSLDCDRRYSCVRMLDWFDH--HGHVCIAFELLGLSTFDFLKENNFQPFPVDQIRHMAYQIIRAVKFLHKNKLTHTDLKPENILFIDSEYDLEYNSKMKRDERTVRNADVKVVDFGNATYEHEHHTTVVSTRHYRAPEVILELGWSHSCDVWSIGCILIEYYLGSTLFQTHDSKEHLAMMERVLGPIPACMLQKTR---KQRYVHHDRLDWDVHSSSGRYVRKHC--KPLRQYMKSKSLDHEELFDLIEKMLEYDVTKRISLDEAIRHPFF 483
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000007667.2 (dual specificity protein kinase CLK4 [Source:NCBI gene;Acc:103034991]) HSP 1 Score: 192.586 bits (488), Expect = 1.045e-55 Identity = 122/331 (36.86%), Postives = 182/331 (54.98%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFH--------KNGALRKDNFHCDVKPLKHL--CKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY I +G+G+FG V C D L VA+K +K ++ + ++E+ VL+++ D + C+Q +D F CIVF + + Y+FLK N +MPF + + + + Q+C+AV+F+H + HTDLKPENI+ + YD Y+ + K K L+NL VKV+DFG A + H+ TRHYRAPEVILE W+ D+WS+GCIL E G T+F ++ EHL ++E+ LG I +++ + K++Y H + R HC KPLK K E DL+ M+ ++ RI EALRH FF
Sbjct: 154 GDMLRARYEIVGTVGEGAFGKVVECIDHSKDGLRVALKIIKNLERYREAALSEVEVLKQMNSLDSENRFACVQMLDWFDHH--GHICIVFELLGLSTYDFLKENDFMPFTVDQIRFMAYQLCRAVHFLHRNKLTHTDLKPENILFVNSEYDTEYNAKLKRDEKTLKNLHVKVVDFGNATYDHEYHTSVVSTRHYRAPEVILELGWNQSCDVWSLGCILIEYYLGITLFQTHDSKEHLAMMERVLGPIPVNMLQKTK---KQRYVHHEKLDWDEHTSSGRYVRKHC--KPLKQYMSSKTSDHEQLFDLLHKMMEYDVSKRITLEEALRHPFF 477
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: clk2a (dual specificity protein kinase CLK2 [Source:NCBI gene;Acc:103024244]) HSP 1 Score: 188.734 bits (478), Expect = 4.805e-54 Identity = 116/329 (35.26%), Postives = 180/329 (54.71%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + + C+Q D F C+ F + + + ++FLK N+Y+P+++ + + + Q+C AV F+H + HTDLKPENI+ + + Y+ K + ++N V+V+DFG A + HS TRHYRAPEVILE W+ D+WSIGCIL+E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL+ EH DLIE+ML RI + +LRH FF
Sbjct: 176 GDVLQERYEIVGTLGEGTFGRVMECIDHRRGGSHVALKIIKNVEKYKEAARLEINVLEKINERDPENKNLCVQMFDWFD--YHGHMCLSFELLALSTFDFLKENNYLPYSISQVRHMAYQICLAVKFLHDNKLTHTDLKPENILFVNSDFTITYNVEKKRDERMVKNTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWNQPCDVWSIGCILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENSSAGRYVRENCKPLRRYILSEAEEHHQLFDLIEAMLEYEPSKRITLAASLRHPFF 499
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: clk2a (dual specificity protein kinase CLK2 [Source:NCBI gene;Acc:103024244]) HSP 1 Score: 188.734 bits (478), Expect = 4.805e-54 Identity = 116/329 (35.26%), Postives = 180/329 (54.71%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+++RY I LG+G+FG V C D VA+K +K ++ + EI+VL++I + D + + C+Q D F C+ F + + + ++FLK N+Y+P+++ + + + Q+C AV F+H + HTDLKPENI+ + + Y+ K + ++N V+V+DFG A + HS TRHYRAPEVILE W+ D+WSIGCIL+E G T+F + EHL ++E+ LG + +I + K+KYF++ +N + KPL+ EH DLIE+ML RI + +LRH FF
Sbjct: 176 GDVLQERYEIVGTLGEGTFGRVMECIDHRRGGSHVALKIIKNVEKYKEAARLEINVLEKINERDPENKNLCVQMFDWFD--YHGHMCLSFELLALSTFDFLKENNYLPYSISQVRHMAYQICLAVKFLHDNKLTHTDLKPENILFVNSDFTITYNVEKKRDERMVKNTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWNQPCDVWSIGCILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYRGRLDWDENSSAGRYVRENCKPLRRYILSEAEEHHQLFDLIEAMLEYEPSKRITLAASLRHPFF 499
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: clk2b (CDC-like kinase 2b [Source:ZFIN;Acc:ZDB-GENE-060929-1126]) HSP 1 Score: 163.31 bits (412), Expect = 2.394e-46 Identity = 102/295 (34.58%), Postives = 158/295 (53.56%), Query Frame = 1
Query: 397 VAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+A+K +K ++ + EI+VL++I + D + C+Q D F CI F + + + ++F+K N+Y+P++L + + + Q+C AV F+H + HTDLKPENI+ + Y+ K + +++ +V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCIL+E G T+F + EHL ++E+ G I +I + K+KYF++ +N + KPL+ EH DL+E ML R+ S LRH FF
Sbjct: 8 IALKIIKNVEKYKEAARLEINVLEKIREKDPENKHLCVQMFDWFD--YHGHMCISFELLALSTFDFMKENNYLPYSLSQVRHMAFQICIAVKFLHDNKLTHTDLKPENILFVSSDFITNYNTEKKREERSVKDTSVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFEYYLGYTLFQTHDNREHLAMMERIQGPIPSRMIRKTR---KQKYFYRGRLDWDENSSAGRYVRENCKPLRRYVLSEAEEHHQLFDLLEGMLEYEPERRLLLSSCLRHPFF 297
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: clk2a (CDC-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-298]) HSP 1 Score: 194.897 bits (494), Expect = 3.403e-57 Identity = 124/331 (37.46%), Postives = 180/331 (54.38%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC-------DVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
IG ++ RY I LG+G+FG V C D +A+K +K +D + EI+VL++I + D + C+Q D F CI F + + ++FLK N+Y+P+ LH+ + + Q+C A+ F+H + HTDLKPENI+ D YD Y+ + K + +RN ++V+DFG A + HS TRHYRAPEV+LE WS D+WSIGCI++E G T+F + EHL ++E+ LG I ++ R K+KYFH +G L D + KPL+ +C + DLIE ML RI EAL+H FF
Sbjct: 161 IGDWLQARYEIISTLGEGTFGKVVHCIDHDRGKAKIALKIIKNVDKYREAARLEINVLEKINEKDPRNKYLCVQMYDWFD--YHGHMCIAFELLGLSTFDFLKENNYLPYPLHQVRLMAYQLCYAIKFLHDNKLTHTDLKPENILFVDSEYDIKYNPQKKRDERTVRNADIRVVDFGSATFDYEHHSTIVSTRHYRAPEVLLELGWSQPCDVWSIGCIVFEFYLGFTLFQTHDNREHLAMMERTLGLIPSRMVRRTR---KQKYFH-HGHLDWDESSSAGKYVRENCKPLRRYVVCDDAQHHQLFDLIEKMLQYEPSKRITLGEALKHPFF 485
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: hipk2 (homeodomain interacting protein kinase 2 [Source:ZFIN;Acc:ZDB-GENE-031125-4]) HSP 1 Score: 126.331 bits (316), Expect = 1.988e-31 Identity = 81/237 (34.18%), Postives = 129/237 (54.43%), Query Frame = 1
Query: 316 YRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA--VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLG 1017
Y + +FLG+G+FG V C + VAIK LK R E+ +L R++ ++ + ++ + F+ + + C+VF M NLY+FLK+N++ P L + ++ QV A+ + SL +IH DLKPENIML R ++ VKVIDFG A V ++ S + Q+R+YRAPE+IL + IDMWS+GC++ EL G ++ ++ ++ + I G
Sbjct: 192 YEVLEFLGRGTFGQVVKCWKRGTSEI-VAIKILKNHPSYARQGQVEVGILARLS-SESADDYNFVRAHECFQHK--SHTCLVFEMLEQNLYDFLKQNNFSPLPLKYIRPVLQQVASALMKLKSLGLIHADLKPENIML-------VDPVRQPYR------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISATQG 411
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 121.324 bits (303), Expect = 3.585e-30 Identity = 81/243 (33.33%), Postives = 121/243 (49.79%), Query Frame = 1
Query: 304 VEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQR----TMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLG 1017
V RY + K +GKGSFG V D + T LK + +++R EI +L+ + D++ S + I ++ F R C+ F + S NLYE +K+N + F+L + + Q ++ +H IIH DLKPENI+L K+ +KVIDFG + E + Q+R YRAPEV+L + IDMWS+GCIL EL+TG + + + L + LG
Sbjct: 158 VAYRYEVLKVIGKGSFGQVVKAFD----HKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRENSMNIIHLLESFTFR--GHVCMTFELLSMNLYELIKKNKFQGFSLALVRKFAHSILQCLDTLHRNRIIHCDLKPENILL---------------KQPGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVVLGARYGPPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELLG 379
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007962.1 (pep scaffold:Pmarinus_7.0:GL476685:157455:173154:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007962.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 114.39 bits (285), Expect = 4.924e-29 Identity = 96/319 (30.09%), Postives = 148/319 (46.39%), Query Frame = 1
Query: 313 RYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRT-MNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLK-------HLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRF 1242
RY + + LG+GSFG V C D + VAIK L ++ EI +L+R+ A + SS I+ ++ F R ++C+VF + + NL LK H F L + + + +++ + ++IH DLKP NI + VK+ DFG + + H QTRHYRAPEVIL+ +SF DMWS+GC L EL +G+ +F + L I + G + +I+ ++ +F K+G R+ + C LK L EH D I S L + R+ A+ H +
Sbjct: 6 RYEVLEVLGQGSFGKVLKCLDHKSKEF-VAIKVLNRARFNESVHRREIEILKRLQTA--RESSKIIRMMEHFSFR--GRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAG---------------EVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIE--ESRVQLGFFVKSG--RRFSVQCSNVRLKVPGSRALPLALRTTDEHFTDFIRSCLQWDPEWRLTPHGAMDHEW 300
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: dyrk1aa (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Source:ZFIN;Acc:ZDB-GENE-050302-29]) HSP 1 Score: 119.013 bits (297), Expect = 4.976e-29 Identity = 84/263 (31.94%), Postives = 136/263 (51.71%), Query Frame = 1
Query: 313 RYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLK----YIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHS--LHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAVE-GSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHK 1080
RY I+ +GKGSFG V D VAIK +K +++ Q E+ +L+ + D + + F R N C+VF + S NLY+ L+ ++ +L+ + Q+C A+ F+ + L IIH DLKPENI+L + + +K++DFG + + G ++ Q+R YR+PEV+L + IDMWS+GCIL E+ TGE +F SN + + I + LG ++++ +A +KYF +
Sbjct: 161 RYEIDSLIGKGSFGQVVKAYDHQEQEW-VAIKIIKNKKAFLNQAQI---EVRLLELMNKHDTDMKYYIVHLKRHFMFR--NHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNP---------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGLPPTHMLEQAPKA--RKYFER 400
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KNS1 (Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation [Source:SGD;Acc:S000003942]) HSP 1 Score: 137.887 bits (346), Expect = 1.178e-35 Identity = 86/255 (33.73%), Postives = 133/255 (52.16%), Query Frame = 1
Query: 313 RYRIEKFLGKGSFGFVSACTD-LLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRD--RVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIML---------------XXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLG 1017
R+ ++ LG+G+FG V C D PN VA+K ++ +D + E+ +LQ I + D Q C+ L R+ N C+V +Y ++Y+F+ N F + I Q+ ++V F+H L IIHTDLKPENI++ S + + K K L+N +K+IDFG A+ H TRHYRAPE++L WSF D+WSI C+L EL+ GE+++ EH+ ++++ G
Sbjct: 312 RFVVKDLLGQGTFGKVLKCIDNKYEPNY-VAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCL----LLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRING 561
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: YAK1 (Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]) HSP 1 Score: 112.849 bits (281), Expect = 2.890e-27 Identity = 79/253 (31.23%), Postives = 126/253 (49.80%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDD-QRTMNEISVLQRIADA-DKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAVE-GSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVID 1041
+G ++Y + LG+G+FG V C +LL + +A+K +K + +++ E +L+ + D H ++ D F + N C+VF + S NLYE LK+N + ++ +T Q+ ++ + +IH DLKPENI+L +K+IDFG + E + Q+R YRAPE+IL +S IDMWS+GCI+ EL G IF ++ + L I LG +ID
Sbjct: 361 LGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEI-LAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHK--NHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPE---------------LKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMID 595
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 105.531 bits (262), Expect = 2.447e-25 Identity = 89/324 (27.47%), Postives = 148/324 (45.68%), Query Frame = 1
Query: 295 GTVVE--QRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDD---QRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-VEGSIHSKHCQTRHYRAPEVILE-QEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDR-CSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRF 1242
GTV E RY +G G+FG V + TD L K +K +RT E+ +L+ + + + C+Q D+F + + V + +L+ L+ P + + Q+ + + ++HS +IH DLKP NI++ N +K+ DFG+A ++ + + TR+YRAPE++L Q++ +D+WS GCI E+I G+ +F + II LG + VI+ CSE K H D P K + + A+DL+E ML + + RI +++AL H +
Sbjct: 14 GTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHL----RHENLICLQ--DIFLSPLEDI-YFVTELQGTDLHRLLQTR---PLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN-----------------ENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLK--------FVTSLPHRDPIPFSERFKTVEPD-AVDLLEKMLVFDPKKRITAADALAHPY 301
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SLT2 (Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway [Source:SGD;Acc:S000001072]) HSP 1 Score: 105.145 bits (261), Expect = 4.975e-25 Identity = 91/331 (27.49%), Postives = 154/331 (46.53%), Query Frame = 1
Query: 304 VEQRYRIEKFLGKGSFGFV-SACTDLLAPNLTVAIKFLKYIDDD----QRTMNEISVLQRIADADKQASSHCIQPIDL--FRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-------VEGS-IHSKHCQTRHYRAPEVILE-QEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKF-EHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
V++R+++ K +G G++G V SA A + TVAIK + + +R++ E+ +L+ + C+ +D+ + D N + + C++++ +K P ++ Q+ + +IHS ++H DLKP N+++ + +K+ DFG+A VE S +++ TR YRAPE++L Q ++ ID+WS GCIL E + G+ IF + L I Q LG + R + Y H+ G + K P +L YP ALDL+E ML + + RI EAL H +
Sbjct: 19 VDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFR---GHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQ--PLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNA-----------------DCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPK-------VPFVNL--YPNANSQALDLLEQMLAFDPQKRITVDEALEHPYL 318
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 95.9005 bits (237), Expect = 2.405e-22 Identity = 89/337 (26.41%), Postives = 163/337 (48.37%), Query Frame = 1
Query: 304 VEQRYRIEKFLGKGSFGFVSACTDLLAPN-LTVAIKFLKYIDDD---QRTMNEISVLQRIADADKQASS-HCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFL--KRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA--VEGSIHSK---------HCQTRHYRAPEVILE-QEWSFGIDMWSIGCILYELITGETIFMPSNTFEH-LFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFE---HALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+ +Y++ +G+G++G V C+ + P+ + VAIK ++ RT+ EI +L+ + + S ++P+ + D++ N +V + +L + + + + + + + Q+ +A+ IHS +IH D+KP N++L N +KV DFG+A + S S+ + TR YRAPE++L QE++ +D+WS GCIL E+++G+ +F P + H L++I + LG S ++ K+Y N +R PL + K + +DL++ ML N RI ++EALRH +
Sbjct: 9 IPSQYKLVDLIGEGAYGTV--CSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHENIISILDKVRPVSI--DKL-NAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNS-----------------NCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLF-PGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYI-ANLPMR--------PPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYL 313
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR83]) HSP 1 Score: 175.637 bits (444), Expect = 4.003e-50 Identity = 117/330 (35.45%), Postives = 180/330 (54.55%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKK--LRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDN-------FHCDVKPLKHLCKYPKFEHAL--DLIESMLNVNLRHRIGSSEALRHRFF 1245
G + RY + LG+G+FG V C D ++ VA+K +K I+ + EI VL++I ++ S CI+ +D F C+VF ++++F+K N+Y P+ L + + I Q+ AV F+H + + HTDLKPEN++ + D Y+ +K + +++ +++IDFG A E HS TRHYRAPEVILE WS+ D+WSIGCI++EL TG T+F EHL ++E+ +G I D ++ K KYF+K G L D + KPLK H L +L++ +L + RI + EA++H FF
Sbjct: 118 GDQLHSRYEVHCLLGEGTFGKVLECYDKKTGDV-VAVKVIKNIEKYREAAKLEIKVLEKINQKNRYGKSLCIKMLDWFNHH--GHMCLVFEKMGLSVFDFMKDNNYEPYPLDQVRHISYQLIVAVKFLHEMKLTHTDLKPENMLFVNSDCDVFYNKDTKQDQRYVKSSHMRLIDFGSATFEHEHHSTTVSTRHYRAPEVILELGWSYPCDIWSIGCIMFELYTGFTLFQTHENREHLAMMERIIGPIPS---DFAKKSRKTKYFYK-GKLEWDEKSSSGKYVRENCKPLKKYMLSDSEGHQLFFNLLDYLLEYDPEKRITAKEAMQHPFF 440
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ45]) HSP 1 Score: 130.954 bits (328), Expect = 1.599e-34 Identity = 91/263 (34.60%), Postives = 130/263 (49.43%), Query Frame = 1
Query: 313 RYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALR 1095
RY + + LGKGSFG V D VA+K ++ Q+ + E+ +L + DK + + I I+ F R N CI F + NLYE +K+N++ F+L + + + IH IIH DLKPENI+L ++ ++KVIDFG + E + Q+R YR+PEVIL +S IDMWS GCIL EL TG +F N E L I + LG S +I+ S ++ +F G R
Sbjct: 59 RYEVLEVLGKGSFGQVVKALDH-KTGQHVAVKIIRNKKRFHQQALVEVKILDNLRKKDKDNTHNLIHMIEHFYFR--NHLCITFELMGMNLYELIKKNNFQGFSLALIRRFAFALLHCLKVIHKEKIIHCDLKPENILL---------------RQRGQTSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPSPKLIESASR--RRLFFDSKGIPR 301
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGV4]) HSP 1 Score: 130.568 bits (327), Expect = 2.600e-34 Identity = 87/233 (37.34%), Postives = 133/233 (57.08%), Query Frame = 1
Query: 328 KFLGKGSFGFVSACTDLLAPNLTVAIKFLK-YIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA--VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLG 1017
+FLG+G+FG V C N VAIK LK + ++ EIS+L +++ A+ + + ++ I+ F+ + N C+VF M NLY++LK++ + P L + I+ QV A++ + +L +IH DLKPENIML D+ F+ VKVIDFG A V + S + Q+R+YRAPEVIL + IDMWS+GC++ EL G ++ S+ F+ + I Q G
Sbjct: 3 EFLGRGTFGQVVKCWKK-GTNELVAIKILKDHPSYARQGQIEISILAKLS-AENSEAYNFVRAIECFQHK--NHTCLVFEMLQQNLYDYLKQSKFNPLPLKHIRPIVQQVLVALSKLRTLGLIHADLKPENIML-------VDPDKQPFR------VKVIDFGSATHVSKVVCSTYLQSRYYRAPEVILGLPFCESIDMWSLGCVIAELFLGWPLYPGSSEFDQIRYIIQTQG 218
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO45187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTC8]) HSP 1 Score: 127.102 bits (318), Expect = 2.445e-32 Identity = 103/346 (29.77%), Postives = 162/346 (46.82%), Query Frame = 1
Query: 313 RYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN----EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHS--LHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAVE-GSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIK-------------------KKYFHKNGALRKDNFHCDV---------KPLKHLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
RY IE +GKGSFG V D +A+K +K + + +N E+ +L+ + D + ++ F R N C+VF + S NLY+ L+ ++ +L+ + Q+C A+ F+ S L IIH DLKPENI+L + + +K++DFG + + G ++ Q+R YR+PEV+L ++ IDMWS+GCIL E+ TGE +F +N F+ + I + LG + ++D +A K K+Y D C+ + L Y KF+ DLI ML+ + + RI AL H FF
Sbjct: 78 RYEIESLIGKGSFGQVCKAYDHQEKE-HIAVKIIK---NKKPFLNQAQIEVKLLELMNKNDPDGKYYIVRLKRHFMWR--NHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLCSPELSIIHCDLKPENILLCNP---------------KRSAIKIVDFGSSCQIGQRIYQYIQSRFYRSPEVLLGIPYNLAIDMWSLGCILVEMHTGEPLFSGANEFDQMMKIVEVLGMPPKDILDNAPKARKFFDRLPDGSYQCLKVKDGVKEYLSPGSRKLHDILGCETGGPGGRRLGEAGHTLQDYLKFK---DLILRMLDYDRKTRIVPYAALHHCFF 399
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO46144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQP1]) HSP 1 Score: 127.102 bits (318), Expect = 6.907e-32 Identity = 89/266 (33.46%), Postives = 129/266 (48.50%), Query Frame = 1
Query: 304 VEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQR-TMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALR 1095
+ RY + K +GKGSFG V D N VA+K ++ R EI +L+ + DK + + I ++ F R N C+ F + S NLYE +K+N + F+L + + Q ++ +H IIH DLKPENI+L K+ +KVIDFG + E + Q+R YRAPEVIL + IDMWS GCIL EL+TG +F + + L + LG I + + A K + + G R
Sbjct: 163 IAYRYEVLKIIGKGSFGQVVKALDHKT-NTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHMLEHFTFR--NHVCMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILL---------------KQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACNMELLGYIPEKLRETSKRA--KNFINSKGYPR 408
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: clk2a (dual specificity protein kinase CLK2 [Source:NCBI gene;Acc:101162379]) HSP 1 Score: 192.586 bits (488), Expect = 2.235e-55 Identity = 118/330 (35.76%), Postives = 184/330 (55.76%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKK--LRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHC-------DVKPLKHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V+++RY I LG+G+FG V C D ++VA+K +K ++ + EI+VL++I + D C+Q D F C+ F + + + ++FLK N+Y+P+++ + + + Q+C AV F+H + HTDLKPENI+ + + Y+ K ++ ++N +V+V+DFG A + HS TRHYRAPEVILE WS D+WSIGCIL+E G T+F + EHL ++E+ LG + +I + K+KYF++ G L D + KPL+ EH DLIESML R+ +++L+H FF
Sbjct: 178 GDVLQERYEIVGTLGEGTFGRVMKCIDHRRGGVSVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKFLCVQMYDWFD--YHGHMCLSFELLALSTFDFLKENNYLPYSIGQVRHMAYQICLAVKFLHDSKLTHTDLKPENILFVNSDFTMSYNVEKKREERTVKNTSVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSHPCDVWSIGCILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTR---KQKYFYR-GRLDWDESSSAGKYVRENCKPLRRYLLSEAEEHHQLFDLIESMLEYEPARRLTLADSLKHPFF 501
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: clk2b (dual specificity protein kinase CLK2 [Source:NCBI gene;Acc:101158555]) HSP 1 Score: 186.422 bits (472), Expect = 1.600e-54 Identity = 122/330 (36.97%), Postives = 182/330 (55.15%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYF-----HKNGALRKDNF-HCDVKPLKH--LCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFFL 1248
G V+E RY I LG+G+FG V C D +A+K +K + + T EI+VL++I++ D HC+Q ++ F + CI F + S + ++FLK N+++P+ L + + + Q+C+AV+F+H + HTDLKPENI+ + +Y Y+ K K++ + TV++IDFG A + HS TRHYRAPEVILE WS D+WSIGCIL+E G T+F + EHL ++E+ G + + +I + K+KYF N + + F KPL+ L + H DL+E ML RI AL H FFL
Sbjct: 46 GDVLEDRYEIINTLGEGTFGKVVQCLDHGRGGRQIALKIIKNQEKYRNTAKLEINVLEKISEKDPLHKYHCVQMLEWFN--YNGHICISFQLLSLSTFDFLKSNNFLPYPLQQIRLMAGQICRAVSFLHDNKLTHTDLKPENILFVNSNYSLVYNAEKKCNEKRINDTTVRLIDFGTATFDYEHHSVVISTRHYRAPEVILELGWSHPCDVWSIGCILFEYYEGFTLFQTHDNKEHLAMMERTHGPLPQRMI---QSSRKQKYFCSGHLDWNESSKAGRFVKSKCKPLRQYLLSHGREHHHFFDLMERMLEYEPSKRISLHSALEHPFFL 370
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: clk4a (dual specificity protein kinase CLK2 [Source:NCBI gene;Acc:101161565]) HSP 1 Score: 181.415 bits (459), Expect = 6.683e-51 Identity = 118/333 (35.44%), Postives = 178/333 (53.45%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRI--ADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIML--XXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHK--------NGALRKDNFHCDVKPLKHLCKYPKFEHA--LDLIESMLNVNLRHRIGSSEALRHRFF 1245
G ++ RY I LG+G+FG V C D +A+K +K ID + ++E+ VL+++ DADK+ S C++ +D F CI F + + Y+FLK N++ PF L + + Q+ + V F+H + HTDLKPENI+ + S +Y R + L+N V+++DFG A + H+ TRHYRAPEVIL+ W D+WSIGCIL E G T+F ++ EHL ++E+ LG I ++++ K++Y H+ + + R HC KPLKH +H DLIE M+ + RI +AL H FF
Sbjct: 212 GDMLRARYEIVYTLGEGAFGKVVECIDHANNGELIALKIIKNIDRYREAALSEVEVLKQLNSVDADKRYS--CVRMLDWFD--YHGHICIAFELLGLSTYDFLKENNFQPFPLEHIRHMAFQIIRGVKFLHKNKLTHTDLKPENILFVDSNYSMEYNREKRRDERTLKNPDVRIVDFGNATFDHEHHTSVVSTRHYRAPEVILDLGWDHSCDVWSIGCILIEYYLGTTLFQTHDSKEHLAMMERVLGPIPAKLLEKTR---KRRYVHRSRLDWDGQSSSGRYVRKHC--KPLKHYMWSKGEDHRQLFDLIEKMMEYDPTKRITLEQALHHPFF 535
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000019341.2 (dual specificity protein kinase CLK2 [Source:NCBI gene;Acc:101170453]) HSP 1 Score: 176.792 bits (447), Expect = 2.676e-50 Identity = 110/329 (33.43%), Postives = 179/329 (54.41%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMN-EISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSK--FKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCD-------VKPLKHL-CKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
G V ++RY + LG+G+FG V C D VA+K L+ ++ T EI+VL+ I D C++ +D F+ + CIVF + + +EFL++N ++PF++ + + + ++ +AV+F+H + HTDLKPENI+ +D ++ +K R+L VKV+DFG A + H TRHYRAPEVIL+ W+ D+WS+GC+L+E G+T+F + EHL ++++ LG I ++ + KK+F ++ L+ D +PLK + + + + LDL+ ML + RI EAL H FF
Sbjct: 102 GFVFKERYEVVSILGEGAFGRVMKCLDKRKDEF-VAVKILRNFENSYETARLEIAVLEEINSLDDDNKFACVRMLDWFKHK--RHVCIVFELLGLSTFEFLRQNDFLPFSVEQIRHMAFRIFRAVSFLHRNKLTHTDLKPENILFVSSDFDLEDDPKTMRVCRKPRSLEVKVVDFGTATFDHQHHQSLVSTRHYRAPEVILDLGWNQSCDVWSLGCVLFEFYFGQTLFPSHDCMEHLAMMQEVLGPIPPHLLKQTG----KKHFVQDDRLKWDQQSSSGDCVREPCRPLKSIEAESDEEQQLLDLLSCMLEYDTCRRITLEEALWHPFF 423
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:101170635]) HSP 1 Score: 135.576 bits (340), Expect = 2.401e-34 Identity = 106/348 (30.46%), Postives = 156/348 (44.83%), Query Frame = 1
Query: 304 VEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQR----TMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMA-VEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLK-----------------------------HLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFF 1245
+ RY + K +GKGSFG V D + T LK + +++R EI +L+ + DK +S + I ++ F R N C+ F + S NLYE +K+N + F+L + + Q ++ +H IIH DLKPENI+L K+ +KVIDFG + E + Q+R YRAPEVIL + IDMWS+GCIL EL+TG + + + L I + LG S+ ++D A K + G R +C V L C P F LD ++ L + HR+ S+ALRH +
Sbjct: 189 IAYRYEVLKVIGKGSFGQVVKAFD----HKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMLENFTFR--NHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILL---------------KQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKILDASKRA--KNFVSSKGYPR----YCTVTTLSDGTTVLNGGRSRRGKVRGPPGSKVWSTALKGCDDPLF---LDFLKQCLEWDPAHRMTPSQALRHSWL 506
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000010516.1 (SMESG000010516.1) HSP 1 Score: 793.112 bits (2047), Expect = 0.000e+0 Identity = 395/395 (100.00%), Postives = 395/395 (100.00%), Query Frame = 1
Query: 64 MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAVEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFFL 1248
MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLYDDSYDYCYSDRSKFKKLRNLTVKVIDFGMAVEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFFL
Sbjct: 1 MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLYDDSYDYCYSDRSKFKKLRNLTVKVIDFGMAVEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKYPKFEHALDLIESMLNVNLRHRIGSSEALRHRFFL 395
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000010516.1 (SMESG000010516.1) HSP 1 Score: 687.567 bits (1773), Expect = 0.000e+0 Identity = 346/360 (96.11%), Postives = 349/360 (96.94%), Query Frame = 1
Query: 64 MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKFKKLRNLTVKVIDFGMAVEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCK 1143
MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLYDDSYDYCYSDRSKFKKLRNLTVKVIDFGMAVEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALR ++ + CK
Sbjct: 1 MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRALKQHREKKANKSNARNCKQVDSAPDIGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDDDQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLYDDSYDYCYSDRSKFKKLRNLTVKVIDFGMAVEGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRIESARVRPSDIGFFCK 360
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000071751.1 (SMESG000071751.1) HSP 1 Score: 206.453 bits (524), Expect = 4.245e-61 Identity = 125/326 (38.34%), Postives = 192/326 (58.90%), Query Frame = 1
Query: 301 VVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSK--FKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDN-------FHCDVKPL-KHLCKYPKFEH--ALDLIESMLNVNLRHRIGSSEALRH 1236
++++RY+I K LG+G+FG V+ C DL N VA+K +K ++ + + EI VL+ I D Q I +D F CIVFP+ ++++FLK NHY+ + + + + + Q+ +AV+F+HSL + HTDLKPENI+ + +YD Y + +K K LR+ ++++ID G A E H+ TRHYR EVILE WS+ D+WSIGCIL+EL TG T+FM + EHL ++E+ LG + + ++ K+KYF G L+ D +VKPL +++ ++ + DLI+ ML N + RI SE+LRH
Sbjct: 146 LLKKRYKILKLLGEGTFGRVAQCKDLKNHNNEVAVKVIKAVEKYREAALLEIKVLELIKKTDPQGRKLVIFALDSFN--YHGHMCIVFPLLGPSVFDFLKANHYVGYPMRQVRYMTYQISKAVDFLHSLKLTHTDLKPENILFVNGAYDMQYDESTKKNVKILRDASIQIIDLGSATFEDEHHTTIVATRHYRPLEVILELGWSYPCDVWSIGCILFELYTGITMFMTHDNIEHLAMMERILGHLP---VRMTRKSKKRKYFDDCGRLKWDGESKEGKYVRGEVKPLRRYITRHDDIKELDLFDLIQEMLEYNPKKRITMSESLRH 466
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000033729.1 (SMESG000033729.1) HSP 1 Score: 190.66 bits (483), Expect = 9.008e-54 Identity = 120/330 (36.36%), Postives = 179/330 (54.24%), Query Frame = 1
Query: 292 IGTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSK-FKKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCDVKPLKHLCKY------PKFEHAL---DLIESMLNVNLRHRIGSSEALRHRFF 1245
IG + RY I LG+G+FG V C DL VA+K +K I+ + M EI+VL+ + + D CI+ D F + CI F + +++ FLK N Y+P+ + + + I Q+C AVNF+H + HTDLKPENI+ + Y+ S + K +++ +++IDFG A + HS TRHYRAPEVILE WS D+WSIGCI++EL +G T+F + EHL ++++ LG I + + + K YF +G L + D K ++ CK P E A+ DL+ ML + + R+ S+AL H FF
Sbjct: 333 IGDNLHNRYEINNTLGEGTFGKVVECLDLKRKYDKVAVKIIKNIEKYREAAMLEINVLKFLQEKDPDGKYLCIKMYDWFN--YNGHICISFQLLGLSVFNFLKENEYVPYPMEQVRHIAYQMCFAVNFLHENGLTHTDLKPENILFVNSDYNVISSSKKKQHNVVKSSEIRLIDFGSATFDHEKHSTVVSTRHYRAPEVILELGWSQPCDVWSIGCIVFELFSGSTLFQTHDNREHLAMMDRILGHIPY----KMTRSTPKDYFDIDGKLIWNPIEKDAKFVRENCKRLFSYCKPNNEVAVELFDLLSRMLEYDPKARVKLSDALNHSFF 656
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000041213.1 (SMESG000041213.1) HSP 1 Score: 178.718 bits (452), Expect = 3.859e-49 Identity = 117/331 (35.35%), Postives = 175/331 (52.87%), Query Frame = 1
Query: 295 GTVVEQRYRIEKFLGKGSFGFVSACTDLLAPNLTVAIKFLKYIDD-DQRTMNEISVLQRIADADKQASSHCIQPIDLFRDRVSNQDCIVFPMYSCNLYEFLKRNHYMPFNLHEAKTIILQVCQAVNFIHSLHIIHTDLKPENIMLXXXXXXXXXXXRSKF--KKLRNLTVKVIDFGMAV-EGSIHSKHCQTRHYRAPEVILEQEWSFGIDMWSIGCILYELITGETIFMPSNTFEHLFIIEQFLGRISRSVIDRCSEAIKKKYFHKNGALRKDNFHCD-------VKPLKHLCKYPKFE--HALDLIESMLNVNLRHRIGSSEALRHRFFL 1248
G ++ RYRI K LG+G+FG V C D + VA+K +K ++ + + EI+VL+ I + D ++ I+ ++ F D + CI F + ++++FLK N Y P+ + + I Q+C AV F+H +H+ HTDLKPENI+ + + + K + ++N +++IDFG A + HS TRHYRAPEVILE WS D+WSI CI++EL TG T+F + EHL ++E+ LG R + K +F+ +G L D + D +PL C E DL+ ML RI AL H FFL
Sbjct: 404 GDMIMGRYRIVKTLGEGTFGKVVECVDNDQSSKRVALKIIKNVEKYREAALLEINVLKVIQEKDPESKYLFIKMLNWF-DHYGHM-CISFELCGQSVFDFLKENSYSPYPMEHVRHISYQLCFAVKFLHDIHLTHTDLKPENILFVNSDSILVPNSKRKRDDRVVKNSEIRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSESCDVWSIACIIFELYTGYTLFQTHDNKEHLAMMERILGHFPY----RMARKSKTSFFY-HGKLDWDFYSPDGRYVRENCRPLLRYCTDENQETIEMFDLVSKMLEYEPADRISLGAALSHPFFL 727 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035216 ID=SMED30035216|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1306bpback to top protein sequence of SMED30035216-orf-1 >SMED30035216-orf-1 ID=SMED30035216-orf-1|Name=SMED30035216-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=396bp MKRKLSDSSGYASSKNIKLSYERECPIKKLRSQVIPNPVLSQSLRLGGTRback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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