TLC domain-containing protein

Overview
NameTLC domain-containing protein
Smed IDSMED30035150
Length (bp)1816
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TLC domain-containing protein (SMED30035150) t-SNE clustered cells

Violin plots show distribution of expression levels for TLC domain-containing protein (SMED30035150) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TLC domain-containing protein (SMED30035150) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TLC domain-containing protein (SMED30035150) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30035150

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30035150h1SMcG0017484 Contig2269GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30035150h1SMcG0017484 Contig2269GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
Smed sexual biotypeSMED30035150h1SMcG0017484 Contig48738uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30035150h1SMcG0017484 Contig48738newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Human
Match: CERS1 (ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:14253])

HSP 1 Score: 161.384 bits (407), Expect = 8.374e-44
Identity = 116/350 (33.14%), Postives = 183/350 (52.29%), Query Frame = 2 
Query:  155 DPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALL-----FTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELE-EEISSMKNQSNHNPGSSKSDTLKNGI 1186
            +P+P+Y + + + W S     L   R   D  + L      + + +A    + L      +T  R + T  L  PL+K   ++P D +K  ES WK + Y   WS + Y++  + +Y  +  P  +     F +      +P DI   Y+ Q  FY HSI+ATL +D WR DS +++LHH++T  LI  S+  RYH VG+LVL+LHDI+DV LEFTK+N+Y KSR      ++   A+ G + F   W WFRLY +PLKVL+ T+    +  +   P  + F   +LL+ L   +++ YI +    K+ +GQ+  ++D+RE +  E  S+K      P       L+NG+
Sbjct:   14 EPMPSYAQLVQRGWGS----ALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLLFGT-DYPFFHDPPSV-----FYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATS-HCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYI-VAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKP-------LRNGL 344
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Human
Match: CERS1 (ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:14253])

HSP 1 Score: 157.918 bits (398), Expect = 1.137e-42
Identity = 96/265 (36.23%), Postives = 144/265 (54.34%), Query Frame = 2 
Query:  155 DPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALL-----FTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTN 934
            +P+P+Y + + + W S     L   R   D  + L      + + +A    + L      +T  R + T  L  PL+K   ++P D +K  ES WK + Y   WS + Y++  + +Y  +  P  +     F +      +P DI   Y+ Q  FY HSI+ATL +D WR DS +++LHH++T  LI  S+  RYH VG+LVL+LHDI+DV LEFTK+N+Y KSR      ++   A+ G + F   W WFRLY +PLKVL+ T+
Sbjct:   14 EPMPSYAQLVQRGWGS----ALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLLFGT-DYPFFHDPPSV-----FYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATS 268
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Human
Match: CERS1 (ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:14253])

HSP 1 Score: 138.272 bits (347), Expect = 1.465e-36
Identity = 91/240 (37.92%), Postives = 139/240 (57.92%), Query Frame = 2 
Query:  413 ESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELE-EEISSMK 1129
            ES WK + Y   WS + Y++  + +Y  +  P  +     F +      +P DI   Y+ Q  FY HSI+ATL +D WR DS +++LHH++T  LI  S+  RYH VG+LVL+LHDI+DV LEFTK+N+Y KSR      ++   A+ G + F   W WFRLY +PLKVL+ T+    +  +   P  + F   +LL+ L   +++ YI +    K+ +GQ+  ++D+RE +  E  S+K
Sbjct:    3 ESAWKFLFYLGSWSYSAYLLFGT-DYPFFHDPPSV-----FYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATS-HCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYI-VAFAAKVLTGQVHELKDLREYDTAEAQSLK 234
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Human
Match: CERS1 (ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:14253])

HSP 1 Score: 124.405 bits (311), Expect = 7.371e-32
Identity = 78/207 (37.68%), Postives = 118/207 (57.00%), Query Frame = 2 
Query:  584 YVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQNGVCN 1204
            Y+ Q  FY HSI+ATL +D WR DS +++LHH++T  LI  S+  RYH VG+LVL+LHDI+DV LEFTK+N+Y KSR      ++   A+ G + F   W WFRLY +PLKVL+ T+    +  +   P  + F   +LL+ L   +++ YI +    K+ +GQ+  ++D+RE +   +     S      ++S     G     C 
Sbjct:    5 YLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATS-HCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYI-VAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEEAVAQSSVTFFGTGGARCR 209
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Human
Match: CERS6 (ceramide synthase 6 [Source:HGNC Symbol;Acc:HGNC:23826])

HSP 1 Score: 77.0258 bits (188), Expect = 1.686e-14
Identity = 58/199 (29.15%), Postives = 98/199 (49.25%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWS-----LTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y   ++     L +   + +  +  Y YP +               + +D+++ Y+ +L FY   +F+    D  R D  ++ LHH+++ FLI FS++     VG LVL LHD AD +LE  K+  Y K +  C++    F      VVF++     RL ++PL VL+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQ--------------PLTTDLHYYYILELSFYWSLMFSQFT-DIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFA-----VVFITT----RLGIFPLWVLNTT 287
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Celegans
Match: lagr-1 (Probable ceramide synthase lagr-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XWE9])

HSP 1 Score: 115.546 bits (288), Expect = 7.177e-28
Identity = 78/247 (31.58%), Postives = 123/247 (49.80%), Query Frame = 2 
Query:  221 NFTRYPCDYYFTLEIINAIKI-----SDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFC-ANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGV 943
             + R   DY F   +I+  K      S++ TVL +A +FT  R    ++ L   ++   + P    K  ES WK   Y T W    Y  +   ++ I+  PL +W          +  +   +  +Y  Q  FYIHSI+ATL +D WR DS ++ +HH +   L+  S++  + + G LVL+LHD +D  LE TK++ YLK R +       F   N+ +++F  +W  FRLY Y  K+L+ T +G 
Sbjct:   38 RYARLRPDYSFPSSMISDFKKVSLSNSELYTVLILASIFTFLRY-YLQIRLESWTQQHNIYPRFAHKVPESFWKLTYYGTVWIFAFYFHMCVDSHDIFNDPLSMWIEWESGG---RPKMHWQVQVIYAVQSAFYIHSIYATLFMDLWRKDSWLMFVHHFIALGLLFLSYVDNFTLPGALVLFLHDNSDATLEITKLSFYLKKRTNRQYYKYYFLMGNAAFILFAIIWVIFRLYWYTCKLLYATIYGA 280
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Celegans
Match: hyl-1 (Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ED45])

HSP 1 Score: 65.855 bits (159), Expect = 1.632e-11
Identity = 42/122 (34.43%), Postives = 66/122 (54.10%), Query Frame = 2 
Query:  560 IPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLH 925
            +P  I+W Y+ + GFY +S+      D  R+D   L++HH++T FL+  S+ + +  VG L+L  HD++DV LE  K+  Y     D +   N+   N  +V+F S W   RL  YP  V+ 
Sbjct:   60 VPDTIWWYYMIETGFY-YSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRY-----DAH---NKNMTNFMFVLFFSSWVATRLIYYPFIVIR 172
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Celegans
Match: hyl-1 (Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ED45])

HSP 1 Score: 65.4698 bits (158), Expect = 3.470e-11
Identity = 42/122 (34.43%), Postives = 66/122 (54.10%), Query Frame = 2 
Query:  560 IPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLH 925
            +P  I+W Y+ + GFY +S+      D  R+D   L++HH++T FL+  S+ + +  VG L+L  HD++DV LE  K+  Y     D +   N+   N  +V+F S W   RL  YP  V+ 
Sbjct:  134 VPDTIWWYYMIETGFY-YSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRY-----DAH---NKNMTNFMFVLFFSSWVATRLIYYPFIVIR 246
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Celegans
Match: hyl-1 (Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ED45])

HSP 1 Score: 65.4698 bits (158), Expect = 3.470e-11
Identity = 42/122 (34.43%), Postives = 66/122 (54.10%), Query Frame = 2 
Query:  560 IPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLH 925
            +P  I+W Y+ + GFY +S+      D  R+D   L++HH++T FL+  S+ + +  VG L+L  HD++DV LE  K+  Y     D +   N+   N  +V+F S W   RL  YP  V+ 
Sbjct:  134 VPDTIWWYYMIETGFY-YSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRY-----DAH---NKNMTNFMFVLFFSSWVATRLIYYPFIVIR 246
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Celegans
Match: hyl-1 (Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ED45])

HSP 1 Score: 65.4698 bits (158), Expect = 3.610e-11
Identity = 42/122 (34.43%), Postives = 66/122 (54.10%), Query Frame = 2 
Query:  560 IPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLH 925
            +P  I+W Y+ + GFY +S+      D  R+D   L++HH++T FL+  S+ + +  VG L+L  HD++DV LE  K+  Y     D +   N+   N  +V+F S W   RL  YP  V+ 
Sbjct:  138 VPDTIWWYYMIETGFY-YSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRY-----DAH---NKNMTNFMFVLFFSSWVATRLIYYPFIVIR 250
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Fly
Match: schlank (gene:FBgn0040918 transcript:FBtr0070938)

HSP 1 Score: 72.4034 bits (176), Expect = 2.834e-13
Identity = 62/210 (29.52%), Postives = 93/210 (44.29%), Query Frame = 2 
Query:  329 TRISTTKLLLNPLSK-----------WLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYP 910
            TR+   KL+  PLSK           W R+R     PS + KF E+ W+ + Y     L  ++    G   ++  P   W   +         I +DI+W Y+  + FY  S+  T   D  R D   + +HH++T  L+  S++   H VG LVL +HD AD+ LE  K+  Y K +  C+           + +F  VW   RL  YP
Sbjct:   96 TRLDKKKLV--PLSKQTDMSEREIERWWRLRRAQDKPSTLVKFCENTWRCIYY-----LYSFIF---GVIVLWDKPW-FWDVKSCWYGYPHQSISNDIWWYYMISMSFY-WSLTGTQFFDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQKLCDAI---------FAIFTVVWIVTRLGFYP 284
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Fly
Match: schlank (gene:FBgn0040918 transcript:FBtr0070937)

HSP 1 Score: 72.4034 bits (176), Expect = 2.834e-13
Identity = 62/210 (29.52%), Postives = 93/210 (44.29%), Query Frame = 2 
Query:  329 TRISTTKLLLNPLSK-----------WLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYP 910
            TR+   KL+  PLSK           W R+R     PS + KF E+ W+ + Y     L  ++    G   ++  P   W   +         I +DI+W Y+  + FY  S+  T   D  R D   + +HH++T  L+  S++   H VG LVL +HD AD+ LE  K+  Y K +  C+           + +F  VW   RL  YP
Sbjct:   96 TRLDKKKLV--PLSKQTDMSEREIERWWRLRRAQDKPSTLVKFCENTWRCIYY-----LYSFIF---GVIVLWDKPW-FWDVKSCWYGYPHQSISNDIWWYYMISMSFY-WSLTGTQFFDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQKLCDAI---------FAIFTVVWIVTRLGFYP 284
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Zebrafish
Match: cers1 (ceramide synthase 1 [Source:ZFIN;Acc:ZDB-GENE-050208-406])

HSP 1 Score: 182.185 bits (461), Expect = 1.381e-51
Identity = 115/304 (37.83%), Postives = 166/304 (54.61%), Query Frame = 2 
Query:  299 VLFIA-LLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRI---WKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXX--XXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQN 1192
            +LFI  +++T  R   T     P  +W R++P D+SK  ES WK + Y   WS + Y++  + +Y+ +Q P  +   WK            +P+DI   Y+ Q  FY HSI+AT+ +D WR DS ++V+HH +T  LI FS+  RYH +G+LVL+LHDI DV LEFTK+NVY K+R      IN   +N G V F   W WFRLY +PLKVL    W   IT I   P +  +F   +L+   L      F   +    K+ +GQM  V DVRE +E+    +  S+ +  S++   ++NGI  
Sbjct:   66 MLFICTVMWTKVRKGLTVYFFEPFGQWCRIQPKDVSKMPESAWKLVFYTMSWSYSTYLLFFT-SYSFFQNPPSVFYDWKS--------GMSVPTDIAIAYLIQGSFYGHSIYATVYMDEWRKDSLVMVVHHFITLALITFSYAFRYHNIGILVLFLHDINDVQLEFTKINVYFKTRGGKEYFINDVLSNMGAVSFSITWFWFRLYWFPLKVL----WASCITSIQSVPNIPFYFFFNMLLFALLLMNIYWFLFIVLFVAKVLTGQMKEVNDVREYDEDDLKERKDSS-DEASTEGKHVQNGINK 355
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Zebrafish
Match: cers1 (ceramide synthase 1 [Source:ZFIN;Acc:ZDB-GENE-050208-406])

HSP 1 Score: 179.104 bits (453), Expect = 2.388e-50
Identity = 114/302 (37.75%), Postives = 164/302 (54.30%), Query Frame = 2 
Query:  299 VLFIA-LLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRI---WKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXX--XXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGI 1186
            +LFI  +++T  R   T     P  +W R++P D+SK  ES WK + Y   WS + Y++  + +Y+ +Q P  +   WK            +P+DI   Y+ Q  FY HSI+AT+ +D WR DS ++V+HH +T  LI FS+  RYH +G+LVL+LHDI DV LEFTK+NVY K+R      IN   +N G V F   W WFRLY +PLKVL    W   IT I   P +  +F   +L+   L      F   +    K+ +GQM  V DVRE +E+   +K + + +  +S    +K  I
Sbjct:   61 MLFICTVMWTKVRKGLTVYFFEPFGQWCRIQPKDVSKMPESAWKLVFYTMSWSYSTYLLFFT-SYSFFQNPPSVFYDWKS--------GMSVPTDIAIAYLIQGSFYGHSIYATVYMDEWRKDSLVMVVHHFITLALITFSYAFRYHNIGILVLFLHDINDVQLEFTKINVYFKTRGGKEYFINDVLSNMGAVSFSITWFWFRLYWFPLKVL----WASCITSIQSVPNIPFYFFFNMLLFALLLMNIYWFLFIVLFVAKVLTGQMKEVNDVREYDED--DLKERKDSSDEASTEGYVKRDI 347
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Zebrafish
Match: cers6 (ceramide synthase 6 [Source:ZFIN;Acc:ZDB-GENE-070522-1])

HSP 1 Score: 78.9518 bits (193), Expect = 3.038e-15
Identity = 58/194 (29.90%), Postives = 95/194 (48.97%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y                  I+ Y +R  K +        TD+  D+++ Y+ +L FY+  +F+    D  R D  ++ +HH+ T  L+ FS++     VG LVL LHD ADV+LE  K+  Y+K +  C +          +V+F  V+   RL LYP+ +L+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLARFCESMWRFSFY----------------LYIFTYGVRFLKKVNTFCKSFITDM--DLHYYYILELSFYLSLLFSQFT-DIRRKDFVLMFVHHVSTISLLSFSYVNNMARVGTLVLCLHDAADVLLEAAKMANYVKCQRLCPLL---------FVMFALVFMGSRLALYPVWILNTT 278
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Zebrafish
Match: cers4a (ceramide synthase 4a [Source:ZFIN;Acc:ZDB-GENE-020808-1])

HSP 1 Score: 78.5666 bits (192), Expect = 4.525e-15
Identity = 54/194 (27.84%), Postives = 91/194 (46.91%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            +  WLR R     P++  KF+E+ W+   Y         +I ++G  ++   P   W      +      +    YW Y+ +L FY+ S+   + +D  R D    ++HHI T FLI FS+   Y  VG LV+ +HD +D +LE  K+  Y   R  C+           +VVF +V+   RL ++P ++++  
Sbjct:  120 IQSWLRRRRIQDRPANSRKFSEASWRFGFY--------LIIFSAGLISLIHTPW-FWDHRECWSGYPAQAVAEAQYWYYIIELSFYL-SLLLCVSVDIKRKDFQEQIIHHIATIFLIAFSYCANYVRVGTLVMLVHDSSDFLLESAKMFNYAGWRKTCDAL---------FVVFAAVFLVTRLIVFPFRIVYTA 294
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Zebrafish
Match: cers6 (ceramide synthase 6 [Source:ZFIN;Acc:ZDB-GENE-070522-1])

HSP 1 Score: 75.8702 bits (185), Expect = 2.923e-14
Identity = 57/194 (29.38%), Postives = 95/194 (48.97%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y          I T G   + + P  +W       +     +  D+++ Y+ +L FY+  +F+    D  R D  ++ +HH+ T  L+ FS++     VG LVL LHD ADV+LE  K+  Y+K +  C +          +V+F  V+   RL LYP+ +L+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLARFCESMWRFSFY--------LYIFTYGVRFLKKSPW-LWNTRECWYNYPYQPLTVDLHYYYILELSFYLSLLFSQFT-DIRRKDFVLMFVHHVSTISLLSFSYVNNMARVGTLVLCLHDAADVLLEAAKMANYVKCQRLCPLL---------FVMFALVFMGSRLALYPVWILNTT 287
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000022338.1 (ceramide synthase 1 [Source:NCBI gene;Acc:100485129])

HSP 1 Score: 170.244 bits (430), Expect = 6.689e-47
Identity = 107/325 (32.92%), Postives = 170/325 (52.31%), Query Frame = 2 
Query:  254 TLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXIC--IKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNG--IQNGVCNMNKL 1216
            TL+   ++  +++  +L  AL++T  R +TT+ +  P + W  + P + SK  ES WK + Y   WS + Y++  +  Y  +  P   + G           +P DI   Y+ Q  FY HS +AT+ +D+WR DS +++LHH++T  LI FS+  RYH +G+LVL+LHDI D+ LEFTK+NVY K+R      IN F ++ G V F   W WFRL+ +P KVL+ T +    + +  DP +  +F    L+ +      ++    +    K+ +GQ+  V DVRE +   +        N  +   D L NG  I NG     ++
Sbjct:   45 TLKKHASLTWAELLCLLIGALVWTGLRKATTRWIFQPFAHWCLLHPKEASKVPESAWKLLFYTISWSYSFYLLFFT-EYNFFHDPSSSFHGWK-----SGVQVPRDIAMAYLIQGSFYAHSTYATIYMDSWRKDSIVMILHHVVTFTLITFSYAFRYHNIGILVLFLHDINDIQLEFTKLNVYFKTRGGRYHRINDFISDVGCVTFSMSWFWFRLFWFPQKVLYATCY----SSLESDPNIPFYFFFNSLLFVLTLMNIYWFLYIVMFVVKVLTGQVKEVNDVREYDVSENQKLEVPAKNNNTRHRDALSNGQSILNGCVKKKRM 359
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Xenopus
Match: cers3 (ceramide synthase 3 [Source:NCBI gene;Acc:448139])

HSP 1 Score: 80.4925 bits (197), Expect = 1.174e-15
Identity = 56/199 (28.14%), Postives = 93/199 (46.73%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPL-----RIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     P+ + KF ES W+   Y           +  G   +Y  P       +W G        K ++ +  YW YV +L FY   +F+    D  R D  + V+HH+ T FL+ FS+ ++Y  VG L L +HD++D++LE  K+  Y   +  CNV          +++F  V+   RL ++P  +++ T
Sbjct:  114 VERWFRRRRNQDRPAVLKKFQESCWRFTFYLC--------ALVGGVAVLYDKPWFHDVWEVWVGYP------KQEVLTSQYWYYVMELSFYWALLFSVAS-DVRRKDFKVQVVHHLATIFLLNFSWSVKYIRVGTLTLLVHDLSDILLEAAKMCSYADWKRSCNVL---------FIIFAVVFIISRLIIFPFWIIYAT 288
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Xenopus
Match: cers3 (ceramide synthase 3 [Source:NCBI gene;Acc:448139])

HSP 1 Score: 80.1073 bits (196), Expect = 1.326e-15
Identity = 56/200 (28.00%), Postives = 93/200 (46.50%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPL-----RIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTN 934
            + +W R R     P+ + KF ES W+   Y           +  G   +Y  P       +W G        K ++ +  YW YV +L FY   +F+    D  R D  + V+HH+ T FL+ FS+ ++Y  VG L L +HD++D++LE  K+  Y   +  CNV          +++F  V+   RL ++P  +++ T 
Sbjct:  114 VERWFRRRRNQDRPAVLKKFQESCWRFTFYLC--------ALVGGVAVLYDKPWFHDVWEVWVGYP------KQEVLTSQYWYYVMELSFYWALLFSVAS-DVRRKDFKVQVVHHLATIFLLNFSWSVKYIRVGTLTLLVHDLSDILLEAAKMCSYADWKRSCNVL---------FIIFAVVFIISRLIIFPFWIIYATT 289
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000051557.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:1:73810921:73835965:1 gene:ENSXETG00000016968.1 transcript:ENSXETT00000051557.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.485 bits (184), Expect = 4.588e-14
Identity = 58/203 (28.57%), Postives = 90/203 (44.33%), Query Frame = 2 
Query:  338 STTKLLLNPLSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            +   + +  +  W R R     PS   KF E+ W+ + Y           +T     ++ Y  +               + S +YW Y+ +LGFY  S+  T+  D  R D    ++HH+ T FLI FS+   Y   G LV+ LHD AD ILE  K+  Y K +  C+V          +++F  V+   RL L P +V++ T
Sbjct:  105 AQCNMQIRQVESWFRCRRNQDRPSISKKFCEASWRFVFYVI-------SFLTGLVLAVFFYSFQ--------------PLISSLYWYYIMELGFY-SSLLLTISFDVKRKDLKEQIVHHLATIFLIIFSYCANYIRAGSLVMLLHDTADYILELAKMFNYSKWKRVCDVL---------FIIFAVVFIVTRLVLLPTRVIYST 276
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Xenopus
Match: cers2 (ceramide synthase 2 [Source:NCBI gene;Acc:100036728])

HSP 1 Score: 73.9442 bits (180), Expect = 1.846e-13
Identity = 59/203 (29.06%), Postives = 92/203 (45.32%), Query Frame = 2 
Query:  338 STTKLLLNPLSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
              ++L +  + +W R R     PS   KF E+ W+   Y   +     V+I    +        +WKG        +T +PS  YW Y+ +LGFY   +F  +  D  R D    ++HH+ T  LI FS+   Y  VG LV+ LHD +D  LE  K+  Y   +  C         N  ++VF  V+   R+ ++P  +L+ T
Sbjct:  105 KASRLTVRQVERWFRRRRNEDRPSLQKKFREASWRFTFYLIAFIAGIAVLIDKPWFHDLH---EVWKGFP-----KQTMLPSQ-YWYYMIELGFYWSLLF-RVAFDVKRKDFKEQIIHHVATIVLISFSWCANYIRVGTLVMVLHDASDYFLESAKMFNYAGWKETC---------NGIFIVFALVFIVTRIIIFPFWILYCT 288
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Mouse
Match: Cers1 (ceramide synthase 1 [Source:MGI Symbol;Acc:MGI:2136690])

HSP 1 Score: 170.629 bits (431), Expect = 2.347e-47
Identity = 110/352 (31.25%), Postives = 183/352 (51.99%), Query Frame = 2 
Query:  155 DPLPTYFEFINKTWIS-------FQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEE-EISSMKNQSNHNPGSSKSDTLKNGI 1186
            +P+P+Y + + ++W S         + G    R        L     +   ++   +  AL +T  R + T  +  PL+K  R++P D ++  ES WK + Y   WS   Y+++ + +Y  +  P  +     F +      +P DI   Y+ Q  FY HSI+AT+ +D+WR DS ++++HH++T  LI  S+  RYH VG+LV +LHD++DV LEFTK+N+Y K+R      ++   AN G + F   W WFRLY +PLKVL+ T     +  +   P  + F   +LL+++   +++ YI +    K+ +GQM  +ED+RE +  E  + K      P       L+NG+
Sbjct:   14 EPMPSYAQMLQRSWASALAAAQGCGDCGWGLARR------GLAEHAHLAAPELLLAVLCALGWTALRWAATTHIFRPLAKRCRLQPRDAARLPESAWKLLFYLACWSYCAYLLLGT-SYPFFHDPPSV-----FYDWRSGMAVPWDIAVAYLLQGSFYCHSIYATVYMDSWRKDSVVMLVHHVVTLLLIASSYAFRYHNVGLLVFFLHDVSDVQLEFTKLNIYFKARGGAYHRLHGLVANLGCLSFCFCWFWFRLYWFPLKVLYATC-HCSLQSVPDIPYYFFFNILLLLLMVMNIYWFLYI-VAFAAKVLTGQMRELEDLREYDTLEAQTAKPCKAEKP-------LRNGL 344
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Mouse
Match: Cers4 (ceramide synthase 4 [Source:MGI Symbol;Acc:MGI:1914510])

HSP 1 Score: 80.1073 bits (196), Expect = 1.415e-15
Identity = 88/313 (28.12%), Postives = 143/313 (45.69%), Query Frame = 2 
Query:  338 STTKLLLNPLSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXX-XXICIKLGYK-IASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQNG----VCNMNKLSASTSNSNS 1243
            S   L L    +W R R     PS   KF E+ W+ + Y     L  +V    G  +I  +   +W       +     +   +YW Y+ +LGFY+ S+  TL  D  R D    V+HH +   LIGFS+ +    +G +VL LHD +D +LE  K+  Y   R  C+           +++F  V+ + RL  +P +V++ +   VY +     P    +F  +LL++L +   + F + +++ Y  +  GQM+  ED+R   EE  S    S+  P  S+   LKNG+  G    V N  +  A+   +N 
Sbjct:  105 SQCGLTLRQTQRWFRRRRNQDRPSLSKKFCEACWRFVFY-----LCSFV----GGTSILYHESWLWSPSLCWENYPHQTLNLSLYWWYLLELGFYL-SLLITLPFDVKRKDFKEQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRGCDAL---------FIMFALVFFYTRLIFFPTQVIYTS---VYDSIKNSGPFFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLHKGQMT--EDIRSDVEEPDS----SDDEP-VSEGPQLKNGMARGSRVAVTNGPRSRAAACLTNG 388
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Mouse
Match: Cers6 (ceramide synthase 6 [Source:MGI Symbol;Acc:MGI:2442564])

HSP 1 Score: 77.0258 bits (188), Expect = 1.147e-14
Identity = 60/199 (30.15%), Postives = 97/199 (48.74%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWS-----LTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y   +S     L +   + +  +  Y YP +               + +D+++ Y+ +L FY  S+  +   D  R D  ++ LHH+ T FLI FS++     VG LVL LHD AD +LE  K+  Y K +  C++    F      VVF++     RL ++PL VL+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQ--------------PLTADLHYYYILELSFY-WSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFA-----VVFITT----RLGIFPLWVLNTT 287
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Mouse
Match: Cers6 (ceramide synthase 6 [Source:MGI Symbol;Acc:MGI:2442564])

HSP 1 Score: 77.0258 bits (188), Expect = 1.191e-14
Identity = 60/199 (30.15%), Postives = 97/199 (48.74%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWS-----LTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y   +S     L +   + +  +  Y YP +               + +D+++ Y+ +L FY  S+  +   D  R D  ++ LHH+ T FLI FS++     VG LVL LHD AD +LE  K+  Y K +  C++    F      VVF++     RL ++PL VL+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQ--------------PLTADLHYYYILELSFYW-SLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFA-----VVFITT----RLGIFPLWVLNTT 287
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Mouse
Match: Cers3 (ceramide synthase 3 [Source:MGI Symbol;Acc:MGI:2681008])

HSP 1 Score: 72.4034 bits (176), Expect = 5.688e-13
Identity = 50/162 (30.86%), Postives = 79/162 (48.77%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIIT-SGNYTIYQYPLR--IWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCN 826
            + +WLR+R     P  + KF ES W+          T Y++IT +G   +Y  P    +W+     ND  +  +    YW Y+ ++ FY   +F +L  D  R D    V+HH+    L+ FS+   Y   G LV+++HDI+D+ LE  K+  Y   +  CN
Sbjct:  149 VERWLRIRQKQNKPCRLQKFQESCWR---------FTFYLLITMAGAVFLYDKPWAYDLWE---VWNDYPRQPLLPSQYWYYILEMSFYWSLVF-SLSTDIKRKDFLAHVIHHLAAISLMSFSWCANYIRSGTLVMFIHDISDIWLESAKMFSYAGWKQTCN 297
[Close]
BLAST of TLC domain-containing protein vs. UniProt/SwissProt
Match: sp|P27545|CERS1_MOUSE (Ceramide synthase 1 OS=Mus musculus OX=10090 GN=Cers1 PE=1 SV=1)

HSP 1 Score: 170.629 bits (431), Expect = 1.642e-46
Identity = 110/352 (31.25%), Postives = 183/352 (51.99%), Query Frame = 2 
Query:  155 DPLPTYFEFINKTWIS-------FQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEE-EISSMKNQSNHNPGSSKSDTLKNGI 1186
            +P+P+Y + + ++W S         + G    R        L     +   ++   +  AL +T  R + T  +  PL+K  R++P D ++  ES WK + Y   WS   Y+++ + +Y  +  P  +     F +      +P DI   Y+ Q  FY HSI+AT+ +D+WR DS ++++HH++T  LI  S+  RYH VG+LV +LHD++DV LEFTK+N+Y K+R      ++   AN G + F   W WFRLY +PLKVL+ T     +  +   P  + F   +LL+++   +++ YI +    K+ +GQM  +ED+RE +  E  + K      P       L+NG+
Sbjct:   14 EPMPSYAQMLQRSWASALAAAQGCGDCGWGLARR------GLAEHAHLAAPELLLAVLCALGWTALRWAATTHIFRPLAKRCRLQPRDAARLPESAWKLLFYLACWSYCAYLLLGT-SYPFFHDPPSV-----FYDWRSGMAVPWDIAVAYLLQGSFYCHSIYATVYMDSWRKDSVVMLVHHVVTLLLIASSYAFRYHNVGLLVFFLHDVSDVQLEFTKLNIYFKARGGAYHRLHGLVANLGCLSFCFCWFWFRLYWFPLKVLYATC-HCSLQSVPDIPYYFFFNILLLLLMVMNIYWFLYI-VAFAAKVLTGQMRELEDLREYDTLEAQTAKPCKAEKP-------LRNGL 344
[Close]
BLAST of TLC domain-containing protein vs. UniProt/SwissProt
Match: sp|P27544|CERS1_HUMAN (Ceramide synthase 1 OS=Homo sapiens OX=9606 GN=CERS1 PE=1 SV=1)

HSP 1 Score: 161.384 bits (407), Expect = 4.021e-43
Identity = 116/350 (33.14%), Postives = 183/350 (52.29%), Query Frame = 2 
Query:  155 DPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALL-----FTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELE-EEISSMKNQSNHNPGSSKSDTLKNGI 1186
            +P+P+Y + + + W S     L   R   D  + L      + + +A    + L      +T  R + T  L  PL+K   ++P D +K  ES WK + Y   WS + Y++  + +Y  +  P  +     F +      +P DI   Y+ Q  FY HSI+ATL +D WR DS +++LHH++T  LI  S+  RYH VG+LVL+LHDI+DV LEFTK+N+Y KSR      ++   A+ G + F   W WFRLY +PLKVL+ T+    +  +   P  + F   +LL+ L   +++ YI +    K+ +GQ+  ++D+RE +  E  S+K      P       L+NG+
Sbjct:   14 EPMPSYAQLVQRGWGS----ALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLLFGT-DYPFFHDPPSV-----FYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATS-HCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYI-VAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKP-------LRNGL 344
[Close]
BLAST of TLC domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9XWE9|LAGR1_CAEEL (Probable ceramide synthase lagr-1 OS=Caenorhabditis elegans OX=6239 GN=lagr-1 PE=3 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 9.130e-27
Identity = 78/247 (31.58%), Postives = 123/247 (49.80%), Query Frame = 2 
Query:  221 NFTRYPCDYYFTLEIINAIKI-----SDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFC-ANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGV 943
             + R   DY F   +I+  K      S++ TVL +A +FT  R    ++ L   ++   + P    K  ES WK   Y T W    Y  +   ++ I+  PL +W          +  +   +  +Y  Q  FYIHSI+ATL +D WR DS ++ +HH +   L+  S++  + + G LVL+LHD +D  LE TK++ YLK R +       F   N+ +++F  +W  FRLY Y  K+L+ T +G 
Sbjct:   38 RYARLRPDYSFPSSMISDFKKVSLSNSELYTVLILASIFTFLRY-YLQIRLESWTQQHNIYPRFAHKVPESFWKLTYYGTVWIFAFYFHMCVDSHDIFNDPLSMWIEWESGG---RPKMHWQVQVIYAVQSAFYIHSIYATLFMDLWRKDSWLMFVHHFIALGLLFLSYVDNFTLPGALVLFLHDNSDATLEITKLSFYLKKRTNRQYYKYYFLMGNAAFILFAIIWVIFRLYWYTCKLLYATIYGA 280
[Close]
BLAST of TLC domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5E9R6|CERS4_BOVIN (Ceramide synthase 4 OS=Bos taurus OX=9913 GN=CERS4 PE=2 SV=1)

HSP 1 Score: 83.1889 bits (204), Expect = 1.004e-15
Identity = 80/293 (27.30%), Postives = 131/293 (44.71%), Query Frame = 2 
Query:  386 RPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQY-----PLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXX----XXICIKLGYKIASGQMSG--VEDVRELE-------EEISSMKNQSNHNPGSSKSDTLKNGIQNGVCNMN 1210
            RP    KF ES WK + Y              G   +Y       P++ W+   + +  LK   P   +W Y+ +L FYI S+  TL  D  R D    V+HH +T  LI FS+ +    +G LVL LHD AD +LE +K+  Y+  R  C+           +++F  V+ + RL L+P ++L+ T    +   IG     + ++   +L+++    +       +C+   + I  GQM      DV EL+       EE   MKN +   PG++ +D  ++     + N +
Sbjct:  126 RPCLTKKFCESSWKFVFY--------LCCFVCGTMVLYHESWLWTPVKCWEN--YPHQPLK---PGLYHW-YLLELSFYI-SLLMTLPFDTKRKDFKEQVIHHFVTIILISFSYSLNLLRIGSLVLLLHDSADYLLEASKLFNYMHWRRMCDTL---------FIIFSLVFFYTRLVLFPTRILYTT----FFESIGNFSPFFGYYFLNILLVILQLLHVFWSWLILCMIYSF-IKKGQMEKDVRSDVEELDSSDGEAAEECPQMKNGAAQRPGAAPTDGPRSRAAGRMVNRH 389
[Close]
BLAST of TLC domain-containing protein vs. UniProt/SwissProt
Match: sp|Q84QC0|ASCL3_ORYSJ (ASC1-like protein 3 OS=Oryza sativa subsp. japonica OX=39947 GN=Os03g0264000 PE=2 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 1.363e-15
Identity = 61/242 (25.21%), Postives = 116/242 (47.93%), Query Frame = 2 
Query:  272 AIKISDVATVLFIALLFTI----TRISTTKLLLNPLSKWL-----------RVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYIT 952
            AI+  + ++   + L+F++     R    +L+  PL+ +             VR + I KF+ES+WK   Y    S+  +V++      I Q P  +   + +        + S +   Y+ Q GFYI+SIFA +  +  R D  +++ HH++T+ LIG++++  +  +G ++L LHD +DV LE  K+         C  T  +  A+  + +F   W   RL  +P  ++  +++   I+
Sbjct:    2 AIRGPEASSFFPLTLVFSVGFFCARFFLDRLVYKPLAAYCFSSKASKLMNDEVRQAKIVKFSESIWKLTYYG---SVQAWVLLI-----IKQEPWSL-DTMQYFEGWPNQYMTSSLMLFYMCQCGFYIYSIFALVAWETRRKDFAVMMSHHVVTSILIGYAYLTGFFRIGTIILALHDASDVFLETAKL---------CKYTEKELGASLFFGLFALSWLLLRLIYFPFWIIKTSSYQSIIS 225
[Close]
BLAST of TLC domain-containing protein vs. TrEMBL
Match: A0A267H6D9 (TLC domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025424g1 PE=4 SV=1)

HSP 1 Score: 285.419 bits (729), Expect = 3.268e-87
Identity = 151/352 (42.90%), Postives = 225/352 (63.92%), Query Frame = 2 
Query:  143 QYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQNGV 1198
             Y +DP  T  EF ++  +S  EF  N T+YP DY FTL ++ + ++ DV   + +A+LFT  R   +     P++ WL+++P+   K+ ES+WK + Y+  W  + YV++ SG Y  +  P+ I +G+ F  + L+  +PSDIYW+Y  QLGFY+HS++ATL +DAWR DS M++ HH LT FL+ FS +M+Y+  G LVL+LHD++D+ILEFTK+NVYLK R      +N++ AN G+V+F   WAWFRLY +PLKVL+ ++W VY+   G+DPKM++FFNSML  L  L+ YWFY  + L  ++A+G    +ED RE EE     +  + H    S  D  ++G    +
Sbjct:   15 SYYEDPSLT--EFFHRIGLSLGEFAFNSTKYPHDYAFTLRMLRSWRLVDVGGAVLLAVLFTALRYVISVCFSLPVANWLQIQPASKLKWPESIWKFIAYSGLWLYSLYVVLLSGRYDFFHNPVDILRGIIFDENYLEKPLPSDIYWMYALQLGFYLHSVYATLFMDAWRKDSIMMLFHHGLTIFLLEFSLLMKYYKTGALVLFLHDLSDIILEFTKINVYLKDRGKKFFLLNEWLANIGFVIFAFSWAWFRLYWFPLKVLYPSHWSVYLYHQGRDPKMFVFFNSMLFALQILHIYWFYFIVLLLVRVATGTQREIEDTREYEEA-ERHRRLNGHQESPSGDDASQDGAATSI 363
[Close]
BLAST of TLC domain-containing protein vs. TrEMBL
Match: A0A1I8I5B8 (TLC domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig024247g2 PE=4 SV=1)

HSP 1 Score: 284.648 bits (727), Expect = 6.381e-87
Identity = 158/364 (43.41%), Postives = 232/364 (63.74%), Query Frame = 2 
Query:  143 QYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEE-EISSMKNQSNHNPGSSKSDTLKNGIQNGVCNMNKLSASTS 1231
             Y +DP  T  EF ++  +S  EF  N T+YP DY FTL ++ + ++ DV   + +A+LFT  R   +     P++ WL+++P+   K+ ES+WK + Y+  W  + YV++ SG Y  +  P+ I +G+ F  + L+  +PSDIYW+Y  QLGFY+HS++ATL +DAWR DS M++ HH LT FL+ FS +M+Y+  G LVL+LHD++D+ILEFTK+NVYLK R      +N++ AN G+V+F   WAWFRLY +PLKVL+ ++W VY+   G+DPKM++FFNSML  L  L+ YWFY  + L  ++A+G    VED RE EE E     N    +PG      + +  Q+G  +    SA+TS
Sbjct:   15 SYYEDPSLT--EFFHRIGLSLGEFAFNSTKYPHDYAFTLRMLRSWRLVDVGGAVLLAVLFTALRYVISVCFSLPVANWLQIQPASKLKWPESIWKFIAYSGLWLYSLYVVLLSGRYDFFHNPVDILRGIIFDENYLEKPLPSDIYWMYALQLGFYLHSVYATLFMDAWRKDSIMMLFHHGLTIFLLEFSLLMKYYKTGALVLFLHDLSDIILEFTKINVYLKDRGKKFFLLNEWLANIGFVIFAFSWAWFRLYWFPLKVLYPSHWSVYLYHQGRDPKMFVFFNSMLFALQILHIYWFYFIVLLLVRVATGTQREVEDTREYEEAERHRRLNGHQESPG------VDDASQDGTVD----SAATS 366
[Close]
BLAST of TLC domain-containing protein vs. TrEMBL
Match: A0A267GW44 (TLC domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002321g1 PE=4 SV=1)

HSP 1 Score: 282.722 bits (722), Expect = 2.915e-86
Identity = 150/343 (43.73%), Postives = 228/343 (66.47%), Query Frame = 2 
Query:  140 EQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSD 1168
            + Y +DP  T+++F  +  IS  EF  N T+YP DY FT +++ ++K++D+ TVL +  +FTI R   T  +  PL++ L ++  + +K+ ESVWK ++Y   W  + YV+I SG +  +Q PL I+K + F    L   IP D+YW+Y  QLGFY+HSI+ TL +D WR DS M++ HH LT FL+ FSF+M+Y+ +G LVL +HD++DVILE TK+N+Y+K R   +  ++++ AN G++ F   WAWFRL+ +PLKVL+ ++WGVY+    KDPKM+LFFN+ML +L FL+ YWFY  + L  K+ASG+   V+D RE +E  S   +  + +P  S+ +
Sbjct:   16 DSYYEDP--TFYQFFERILISLNEFAYNGTKYPHDYQFTYQMVTSVKLTDILTVLMLGTVFTILRCIVTATVSLPLAESLNLKRCNRAKWPESVWKFLIYTGLWGYSYYVVIYSGRHNFFQKPLDIFKDIVFDEGYLTRPIPVDVYWMYALQLGFYVHSIYGTLYMDVWRKDSYMMLFHHGLTIFLLEFSFLMKYYKIGALVLLIHDLSDVILELTKLNIYMKDRAGRHWPLHEWMANIGFLAFTVSWAWFRLFWFPLKVLYTSHWGVYVYHKDKDPKMFLFFNTMLFVLQFLHIYWFYFVLVLLVKVASGRQKEVDDTREFDERDSENGSGGHGSPKRSEGE 356
[Close]
BLAST of TLC domain-containing protein vs. TrEMBL
Match: A0A267EDE1 (TLC domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig020862g1 PE=4 SV=1)

HSP 1 Score: 280.026 bits (715), Expect = 2.750e-85
Identity = 149/343 (43.44%), Postives = 226/343 (65.89%), Query Frame = 2 
Query:  140 EQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSD 1168
            + Y +DP  T ++F  +  IS  EF  N T+YP DY FT  ++ ++K++D+ TVL +  +FTI R   T  +  PL++ L ++  + +K+ ESVWK ++Y   W  + YV+I SG +  +Q PL I+K + F    L   IP D+YW+Y  QLGFY+HSI+ T+ +D WR DS M++ HH LT FL+ FSF+M+Y+ +G LVL +HD++DVILE TK+N+Y+K R   +  ++++ AN G++ F   WAWFRL+ +PLKVL+ ++WGVY+    KDPKM+LFFN+ML +L FL+ YWFY  + L  K+ASG+   V+D RE +E  S   +  + +P  S+ +
Sbjct:   15 DSYYEDP--TLYQFFERILISLNEFAYNGTKYPHDYQFTYHMVTSVKLTDILTVLMLGTVFTILRYIVTATVSLPLAESLNLKRGNRAKWPESVWKFLIYTGLWGYSYYVVIYSGRHNFFQKPLDIFKDIVFDEGYLTRPIPVDVYWMYALQLGFYVHSIYGTVYMDVWRKDSYMMLFHHGLTIFLLEFSFLMKYYKIGALVLLIHDLSDVILELTKLNIYMKDRAGRHWPLHEWMANIGFLAFTVSWAWFRLFWFPLKVLYTSHWGVYVYHKDKDPKMFLFFNTMLFVLQFLHIYWFYFVLVLLVKVASGRQKEVDDTREFDERDSENGSGGHGSPKRSEGE 355
[Close]
BLAST of TLC domain-containing protein vs. TrEMBL
Match: A0A1I8G8D1 (TLC domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 279.641 bits (714), Expect = 4.040e-85
Identity = 149/343 (43.44%), Postives = 226/343 (65.89%), Query Frame = 2 
Query:  140 EQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSD 1168
            + Y +DP  T ++F  +  IS  EF  N T+YP DY FT  ++ ++K++D+ TVL +  +FTI R   T  +  PL++ L ++  + +K+ ESVWK ++Y   W  + YV+I SG +  +Q PL I+K + F    L   IP D+YW+Y  QLGFY+HSI+ T+ +D WR DS M++ HH LT FL+ FSF+M+Y+ +G LVL +HD++DVILE TK+N+Y+K R   +  ++++ AN G++ F   WAWFRL+ +PLKVL+ ++WGVY+    KDPKM+LFFN+ML +L FL+ YWFY  + L  K+ASG+   V+D RE +E  S   +  + +P  S+ +
Sbjct:   15 DSYYEDP--TLYQFFERILISLNEFAYNDTKYPHDYQFTYHMVTSVKLTDILTVLMLGTVFTILRYIVTATVSLPLAESLNLKRGNRAKWPESVWKFLIYTGLWGYSYYVVIYSGRHNFFQKPLDIFKDIVFDEGYLTRPIPVDVYWMYALQLGFYVHSIYGTVYMDVWRKDSYMMLFHHGLTIFLLEFSFLMKYYKIGALVLLIHDLSDVILELTKLNIYMKDRAGRHWPLHEWMANIGFLAFTVSWAWFRLFWFPLKVLYTSHWGVYVYHKDKDPKMFLFFNTMLFVLQFLHIYWFYFVLVLLVKVASGRQKEVDDTREFDERDSENGSGGHGSPKRSEGE 355
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Cavefish
Match: cers1 (ceramide synthase 1 [Source:ZFIN;Acc:ZDB-GENE-050208-406])

HSP 1 Score: 189.889 bits (481), Expect = 1.401e-54
Identity = 124/307 (40.39%), Postives = 174/307 (56.68%), Query Frame = 2 
Query:  284 SDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRI---WKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQNG 1195
            S+VA      +++T  R + T  +  P + W R++P D++K  ES WK + Y   WS + Y++  S +YT +Q P  +   WK            +P+DI   Y+ Q  FY HSI+AT+ +DAWR DS ++VLHHI+T  LI FS+  RYH +G+LVL+LHDI D+ LEFTK+NVY K+R      IN   +N G V F   W WFRLY +PLKVL+ +   +   Q   +   YLFFN++L+ LL +N YWF   +    K+ +GQM  V DVRE EEE +    Q   +    +       IQNG
Sbjct:   52 SEVALFFVCVVMWTELRRTLTAHVFEPFAWWCRIQPKDVAKLPESAWKLVFYTMSWSYSSYLLFFS-SYTFFQDPPSVFYDWKS--------GMSVPTDIAIAYLIQGSFYGHSIYATVYMDAWRKDSKVMVLHHIITLALITFSYAFRYHNIGVLVLFLHDINDIQLEFTKLNVYFKTRGGSYYLINDILSNMGSVSFSITWFWFRLYWFPLKVLYAS--CISSQQTVPNIPFYLFFNTLLIALLIMNIYWFLFIVMFVVKVLTGQMKEVSDVREYEEENAQKPLQPKRDDNGHQDAGEGKHIQNG 347
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Cavefish
Match: cers2b (ceramide synthase 2b [Source:ZFIN;Acc:ZDB-GENE-110408-40])

HSP 1 Score: 80.4925 bits (197), Expect = 5.731e-16
Identity = 58/199 (29.15%), Postives = 94/199 (47.24%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPL-----RIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            L +W R R     P+ + KF E+ W+ + Y         +   SG   +   P       +WKG         T +PS  YW Y+F+L FY   +F ++  D  R D    ++HH+ T  LI FS+ M Y   G L+++LHD +D +LE  K+  Y   R  CN           ++VF + +   RL+++P ++++ T
Sbjct:  114 LQRWFRRRRNQDRPNLMKKFREASWRFLFYL--------LAFISGVVALIDKPWLYDLEEMWKGFP-----TLTLLPSQ-YWYYMFELSFYTSLLF-SVATDVKRKDFKEQIIHHVATITLISFSWCMNYIRAGTLIMFLHDSSDYLLESAKMFNYAGWRKTCNYI---------FIVFAAFFIITRLFIFPFRIMYCT 288
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Cavefish
Match: cers2b (ceramide synthase 2b [Source:ZFIN;Acc:ZDB-GENE-110408-40])

HSP 1 Score: 78.9518 bits (193), Expect = 1.791e-15
Identity = 55/196 (28.06%), Postives = 93/196 (47.45%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVY--ATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            L +W R R     P+ + KF E+ W+ + Y  A    +   + +++GN                      T +PS  YW Y+F+L FY   +F ++  D  R D    ++HH+ T  LI FS+ M Y   G L+++LHD +D +LE  K+  Y   R  CN           ++VF + +   RL+++P ++++ T
Sbjct:  114 LQRWFRRRRNQDRPNLMKKFREASWRFLFYLLAFISGVVALIDVSNGN----------------------TLLPSQ-YWYYMFELSFYTSLLF-SVATDVKRKDFKEQIIHHVATITLISFSWCMNYIRAGTLIMFLHDSSDYLLESAKMFNYAGWRKTCNYI---------FIVFAAFFIITRLFIFPFRIMYCT 276
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Cavefish
Match: cers6 (ceramide synthase 6 [Source:NCBI gene;Acc:103028461])

HSP 1 Score: 78.9518 bits (193), Expect = 2.165e-15
Identity = 64/199 (32.16%), Postives = 100/199 (50.25%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSL-TRYVIITSGNYTI----YQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y   ++   RY+  T   +      Y YP   ++ LT            D+++ Y+ +L FY+  +F+    D  R D  ++ +HH+ T  LI FS++     VG LV+ LHD ADV+LE  K+  Y KS+  CNV    F      +VF+S     RL +YP+ VL+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLTRFCESMWRFTFYLYIFTYGVRYLKKTQWLWNTRECWYNYP---YQALTV-----------DLHYYYILELSFYLSLLFSQFT-DIRRKDFLLMFMHHLATISLITFSYVNNMARVGTLVMCLHDAADVLLEAAKMANYAKSQRLCNVLFIMFA-----LVFISS----RLGIYPVWVLNST 287
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Cavefish
Match: cers6 (ceramide synthase 6 [Source:NCBI gene;Acc:103028461])

HSP 1 Score: 78.9518 bits (193), Expect = 2.491e-15
Identity = 64/199 (32.16%), Postives = 100/199 (50.25%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSL-TRYVIITSGNYTI----YQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS +++F ES+W+   Y   ++   RY+  T   +      Y YP   ++ LT            D+++ Y+ +L FY+  +F+    D  R D  ++ +HH+ T  LI FS++     VG LV+ LHD ADV+LE  K+  Y KS+  CNV    F      +VF+S     RL +YP+ VL+ T
Sbjct:  113 IQRWFRQRRNQEKPSTLTRFCESMWRFTFYLYIFTYGVRYLKKTQWLWNTRECWYNYP---YQALTV-----------DLHYYYILELSFYLSLLFSQFT-DIRRKDFLLMFMHHLATISLITFSYVNNMARVGTLVMCLHDAADVLLEAAKMANYAKSQRLCNVLFIMFA-----LVFISS----RLGIYPVWVLNST 287
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009225.1 (pep scaffold:Pmarinus_7.0:GL487342:1832:7642:1 gene:ENSPMAG00000008340.1 transcript:ENSPMAT00000009225.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 144.436 bits (363), Expect = 1.362e-40
Identity = 74/180 (41.11%), Postives = 109/180 (60.56%), Query Frame = 2 
Query:  353 LLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVT---INQFCANSGYVVFVSVW 883
            L  PL+  LR+RP D++KF E+ WK + Y   W  + Y++    +Y  +  PL       F    +  ++PSDI+  Y+ Q  FY+HS++ TL LD WR DS +++LHHI+T  LIGFS+  R+H +G+LVL+LHD +D +LEFTKVNVYL+ R   +     ++   A+ G   F S W
Sbjct:    1 LSQPLAAKLRLRPQDVAKFPENAWKLVFYLGAWLYSGYLLFMR-DYNFFSQPLS-----AFAGWYVGMEVPSDIHLAYMLQGSFYLHSVYGTLCLDTWRRDSPVMILHHIITLSLIGFSYAFRFHNIGLLVLFLHDTSDFLLEFTKVNVYLRHRGGGSERQRWVHACIADFGCAAFGSSW 174
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010799.1 (pep scaffold:Pmarinus_7.0:GL476346:662815:681391:1 gene:ENSPMAG00000009784.1 transcript:ENSPMAT00000010799.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 123.25 bits (308), Expect = 7.982e-32
Identity = 91/277 (32.85%), Postives = 145/277 (52.35%), Query Frame = 2 
Query:  359 NPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTD--IPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFI-MRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKN 1180
             P+++WLR+RP+D  KF ES WK + Y   W    ++++    Y  Y  P  ++    +    L+TD  +P  +  L+ F    Y +++F  +    W+ +S  L L         G  +  + YH VGML L+LHD+ D+ LEFTK+NVYLK+R +    +N   +N G + F   W  FRLY +PLKVL+ T   V   Q   D   Y FFN +L  +  +N YWF + +    K+ +G+++ V+DVRE + E+   + +      S+K+  +K 
Sbjct:    5 RPMAQWLRLRPADADKFPESCWKLLFYLAIWLYAAHLLVKE-EYPFYHNPAAVFYDCRYV--ALRTDMAVPWVLGGLF-FCKSLYSYTVFNKMDTSVWKVNSGCLSLK-------CGMMYTWITYHNVGMLALFLHDVTDIQLEFTKLNVYLKTRNNTYHRLNNILSNIGCITFAVSWFVFRLYWFPLKVLYAT--CVSSMQTVPDIPFYFFFNCLLFTIALMNLYWFSLILMFVMKVVTGRITEVDDVREYDIELKKAEMRPAGGDASNKNHYIKG 268
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009211.1 (pep scaffold:Pmarinus_7.0:GL476916:175486:192535:1 gene:ENSPMAG00000008314.1 transcript:ENSPMAT00000009211.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.8702 bits (185), Expect = 4.849e-15
Identity = 58/194 (29.90%), Postives = 95/194 (48.97%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            +  W R R     PS ++KF+ES+W+   Y        + I   G   +++ P  +W       +     + + ++W Y+ +L FY   +F+   +D  R D  ++++HH+ T  L+ FS++     VG LVL LHD AD +LE  K+  Y K +  C+     F      +VF+S     RL LYPL +L+ T
Sbjct:  114 IEHWFRQRRNQEKPSLVTKFSESLWRFCFY--------FGIFCFGLQYLWKTPW-LWDTKHCWYNYPYQPLTAGLFWYYIVELAFYWSLMFSQF-VDIKRKDFVIMLVHHLATVSLVSFSYVTNMVRVGTLVLCLHDAADFLLETAKMANYAKFQKLCDTMFALFG-----LVFIST----RLVLYPLWILNST 288
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Sea Lamprey
Match: cers6 (ceramide synthase 6 [Source:ZFIN;Acc:ZDB-GENE-070522-1])

HSP 1 Score: 72.0182 bits (175), Expect = 6.406e-14
Identity = 52/187 (27.81%), Postives = 93/187 (49.73%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYP 910
            + +W R R     PS ++KF ES+W+ M Y   + +    +++  N+        +W       +     +PSDI + Y+ +L FY   +F+    D  R D  M+ +HH++T  LI FS+I+    +G ++L +HD AD +LE  K+  Y + +  C++          +++F  V+   RL L+P
Sbjct:   75 IQRWFRRRRNQEKPSPLAKFCESMWRFMFYLYVF-VYGLRLLSQSNW--------VWDSRQCWYNHPYQPLPSDIQYYYIVELAFYWSLMFSQFT-DIKRKDFFMMFMHHLITVSLISFSYIVNMVRMGSVILCMHDAADFLLEAAKMANYARYQKLCDLL---------FILFALVFFVTRLGLFP 242
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Yeast
Match: LAC1 (Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication [Source:SGD;Acc:S000001491])

HSP 1 Score: 47.3654 bits (111), Expect = 4.146e-6
Identity = 56/221 (25.34%), Postives = 94/221 (42.53%), Query Frame = 2 
Query:  281 ISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIY-QYPLRIWKGLTFTNDILKTDIP--SDIYWLYVFQLG----FYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVL 922
            I+D+  V +  + FT  R     +++ P +    +R    SK         +YA F++        SG + IY  Y   +W    F    +    P  ++ +   VF LG    +   +    L+L+  R D N L  HHI+T  LI  S++  +  +G+ +    D++D +L F+K   YL S            A   + +FV  W + R Y+  LK+L
Sbjct:  130 INDLCFVFYYMIFFTFLREFLMDVVIRPFA----IRLHVTSKHRIKRIMEQMYAIFYTGV------SGPFGIYCMYHSDLW---FFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSG----------LAFFSFAIFVVAWIYLRHYI-NLKIL 326
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Nematostella
Match: EDO49866 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7REX2])

HSP 1 Score: 158.688 bits (400), Expect = 7.568e-45
Identity = 84/191 (43.98%), Postives = 115/191 (60.21%), Query Frame = 2 
Query:  362 PLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTN 934
            P +++    P D  KF ES WK + Y + +S T YV+  SG +  +Q  +  WKG           +PSDIY +YV Q GFY HSI+AT+ +D WR DS +++ HHIL   LI FSF  RYH +G++VL+LHDI+D+ LE TK+ +   SRP+    +  F  N+G++ F   W   RLYLYP KVLH T 
Sbjct:    1 PFAEYFNFIPKDKKKFPESAWKLLYYGSAYSFTCYVLF-SGKHQFFQDTVLCWKGWR-----KSMPVPSDIYTIYVVQAGFYFHSIYATVFMDKWRADSIVMICHHILANALILFSFATRYHNIGVIVLFLHDISDIFLEATKIFLCFNSRPNGPFRMFGFLVNAGFLSFALSWFICRLYLYPHKVLHTTG 185
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Nematostella
Match: EDO40047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8D5])

HSP 1 Score: 67.0106 bits (162), Expect = 6.117e-12
Identity = 49/162 (30.25%), Postives = 76/162 (46.91%), Query Frame = 2 
Query:  359 NPLSKWLRVRP-----SDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNV 829
              + KW R RP     S + K  ES W+   Y T       VI+   +   +     +W       D     I  ++Y+ YV +LG YI   F+    D  R D    ++HH  T  L+ +S+I  YH +G +++++HDI+D+ LE  KV  Y K +  C+V
Sbjct:  117 QEVEKWFRRRPAKYNLSPMRKATESSWRFFFYLTATIYGFIVIVYKASNENW-----LWNLDECFKDFNSHVISMELYFYYVAELGMYISLSFSQFT-DVKRKDFWQHMVHHASTIALLLYSYIAGYHRIGAVIVFVHDISDIFLEGAKVFHYAKLQKICDV 272
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Nematostella
Match: EDO43874 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXN1])

HSP 1 Score: 59.6918 bits (143), Expect = 1.449e-9
Identity = 56/204 (27.45%), Postives = 92/204 (45.10%), Query Frame = 2 
Query:  359 NPLSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTD-----IPSDIYWLYVFQLGFYIHSIFATLKLDAWR------TDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVL 922
              + +W R R     PS + K  ES W            R+V  T    TIY + +   +   +  D          +  ++Y  YV +LGFY+ S+  +  +D  R       D   +++HHI+T  L+ FS+   +  +G +++ +HD++DV LE  KV  Y K R  C+     F  +     FV+     RL++YP+ VL
Sbjct:  114 REVERWFRHRRMQSKPSLLKKAKESSW------------RFVFYTGA--TIYGFCILYKEKWLWDTDHCFIGYHGHVMSEELYIYYVVELGFYV-SLTISQFVDVQRKASLRFNDFWQMLIHHIVTILLLSFSYAAAFFRIGAVIVLVHDVSDVFLEAAKVANYAKLRQLCDCLFVLFAIS----FFVA-----RLFIYPVWVL 293
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Medaka
Match: cers1 (ceramide synthase 1 [Source:NCBI gene;Acc:101166466])

HSP 1 Score: 185.267 bits (469), Expect = 9.454e-53
Identity = 128/372 (34.41%), Postives = 194/372 (52.15%), Query Frame = 2 
Query:  155 DPLPTYFEFINK-------TWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRI---WK-GLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMK-------NQSNHNPGSSKSDTLKNGIQNGVCNMNKL 1216
            +P+P Y E + K        W    + GL F++       TL     I  +++   +F A L+T+ R   T+ L  PL++  R+ P D +K  ES WK + Y   WS + Y++  + +Y  +  P  +   WK G+T         +P+DI   Y+ Q  FY HSI+AT+ +D WR DS ++V+HHI+T  LI FS+  RYH VG+LVL+LHDI D+ LEFTKVN+YLKSR      +N   +N G V F   W WFRLY +PLKVL+ T     ++ I   P +  +F    L+   L    ++    + + +   ++  + DVRE E+E  S         ++++ + G  KS   K+ +QNGV     L
Sbjct:   12 EPMPGYLELLTKGFAAMLGAWRDCADCGLRFSKQ------TLLDNAHITWTEIGLFVFCAFLWTMVRWGLTECLFKPLAQRCRLLPKDAAKMPESSWKLVFYTMSWSYSSYLLFFT-SYPFFHDPPSVFYNWKSGMT---------VPTDIAIAYLIQGSFYGHSIYATVNMDEWRKDSAVMVVHHIITLALISFSYAFRYHNVGILVLFLHDINDIQLEFTKVNIYLKSRGGGYHLLNDVLSNLGSVSFSVSWFWFRLYWFPLKVLYATC----VSSIQSVPNIPFYFFFNALLFALLLMNIYWFLFIVVFVVKVLKVKELNDVREYEDEDGSKSAEELLGDSKADEDAGHPKSAQGKH-VQNGVAKEKHL 362
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Medaka
Match: cers5 (ceramide synthase 5 [Source:NCBI gene;Acc:101175231])

HSP 1 Score: 75.485 bits (184), Expect = 3.514e-14
Identity = 85/290 (29.31%), Postives = 136/290 (46.90%), Query Frame = 2 
Query:  356 LNPLSKWLRVR-----PSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYP-----LRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQNG 1195
            +  + +W R R     PS  +KF ES+W+   Y          I T G   ++Q P        W G  +        +   +Y  YV +L FY   +F+  + D  R D  ++ +HH+ T  LI FS++     VG LVL++HD +D +LE  K+  Y KS+  C+     F    G V F++     RL +YP  VL+ T +  + T +G  P  +LF   +L++ +   F+ + I       +  G++   +DVR   E  SS +++SN   G SKS  L +  +NG
Sbjct:  111 VRKVQRWFRHRRNQDKPSTHTKFCESMWRFTFYLG--------IFTYGVQFLWQTPWMWDTRHCWYGYPYQV------MTRGLYLYYVTELAFYWSLMFSQFR-DIKRKDFLIMFVHHLATVGLISFSYVNNMARVGSLVLFVHDTSDFLLEAAKLANYAKSQRLCDFLFILF----GVVFFIT-----RLVIYPYWVLNSTMFESW-TIVGPFPSWWLFNFLLLVLQVLHIFWSYLIARIAIKAMLRGKV--CKDVRSDVE--SSSEDESNTTTGGSKSTHLSSNGENG 371
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Medaka
Match: cers4a (ceramide synthase 2 [Source:NCBI gene;Acc:101175635])

HSP 1 Score: 75.8702 bits (185), Expect = 3.760e-14
Identity = 58/187 (31.02%), Postives = 90/187 (48.13%), Query Frame = 2 
Query:  386 RPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYP-----LRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            RP +  KF E+ W+ + Y T            G  ++   P        W+G        K  + +  YW Y+ ++GFY+ S+  ++ +D  R D    V+HHI T FLIGFS+   Y  VG LV+ +HD +D++LE  K+  Y      C         +S +VVF  V+   RL ++P +V+H T
Sbjct:  163 RPDNTKKFCEASWRFVFYLT--------AFLGGLGSLIDTPWFWDQTECWRGYP------KQAVATAHYWYYMLEMGFYL-SLLLSVSVDVKRKDFKEQVIHHIATLFLIGFSYCANYVRVGTLVMLVHDSSDILLESAKMLHYAVWTRTC---------DSLFVVFAVVFLVSRLVVFPCRVIHTT 325
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Medaka
Match: cers2a (ceramide synthase 2 [Source:NCBI gene;Acc:101162853])

HSP 1 Score: 73.559 bits (179), Expect = 1.471e-13
Identity = 51/182 (28.02%), Postives = 91/182 (50.00%), Query Frame = 2 
Query:  386 RPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            RPS ++KF E+ W+   Y   +     V+I   +   +Q   ++W+      D  K  + +  YW Y+ +LGFY+  +F+    D  R D    ++HH++T  LI FS+++ Y   G L++ +HD AD ++E  K+  Y   +  CN           +V F +V+   RL + P+ ++ +T
Sbjct:  126 RPSKLTKFQEASWRFTFYLFAFYAGLAVLI---DKPWFQDIRKVWE------DFPKMPLLASQYWYYMIELGFYLSLLFSVAS-DVKRKDFWEQIVHHVVTIVLISFSWLVNYVRAGSLIMLVHDAADYLMELAKMFNYAGWKRTCNFL---------FVAFAAVFVITRLMILPVWIVFMT 288
[Close]
BLAST of TLC domain-containing protein vs. Ensembl Medaka
Match: cers2b (ceramide synthase 2-like [Source:NCBI gene;Acc:101160439])

HSP 1 Score: 72.0182 bits (175), Expect = 4.689e-13
Identity = 56/195 (28.72%), Postives = 93/195 (47.69%), Query Frame = 2 
Query:  365 LSKWLRVR-----PSDISKFNESVWKTMVYA-TFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVT 931
            + +W R R     PS + KF E+ W+   Y   F +    +I     Y + Q    +W+G       + T +PS  YW Y+ +LGFY  S+  ++  D  R D    ++HH+ T  LI FS+ + Y   G L++ +HD +D  LE  K+  Y   R  CN           +++F +V+   RL ++P  +++ T
Sbjct:  114 IQRWFRRRRNQDRPSLLKKFREASWRFTFYLLAFIAGLASLIDKPWLYDVKQ----MWEGFP-----VMTLLPSQ-YWYYMIELGFY-GSLLFSVASDVKRKDFKEQIVHHVATILLISFSWCVNYIRAGTLIMLVHDSSDYFLESAKMFNYAGWRNACNYI---------FIIFAAVFIVTRLIIFPFWIIYCT 288
[Close]
BLAST of TLC domain-containing protein vs. Planmine SMEST
Match: SMESG000057441.1 (SMESG000057441.1)

HSP 1 Score: 737.258 bits (1902), Expect = 0.000e+0
Identity = 383/385 (99.48%), Postives = 384/385 (99.74%), Query Frame = 2 
Query:  101 MLSQEEIIYAKSLEQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKXXXXXXXXXXXXXXXXXXXXXICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTLKNGIQNGVCNMNKLSASTSNSNSKKEM 1255
            MLSQEEIIYAKSLEQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKMYLFFNSMLLMLLFLNFYWFYICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDT KNGIQNGVCNMNKLSASTSNSN+KKEM
Sbjct:    1 MLSQEEIIYAKSLEQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYYFTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDISKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKMYLFFNSMLLMLLFLNFYWFYICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNPGSSKSDTPKNGIQNGVCNMNKLSASTSNSNNKKEM 385
[Close]
BLAST of TLC domain-containing protein vs. Planmine SMEST
Match: SMESG000039123.1 (SMESG000039123.1)

HSP 1 Score: 71.2478 bits (173), Expect = 5.060e-13
Identity = 59/209 (28.23%), Postives = 104/209 (49.76%), Query Frame = 2 
Query:  365 LSKWLRVR----PSDI-SKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYPLKVLH-------VTNWGVYITQ 955
            + +W R R     SD+ +KF ES W+ + Y + + +  +V+  S    I+    ++W  + F N      I   ++W  + +LG+Y  S+F T+  D  R D   +++HH++T FLI  +++  +  V M VL LHD  D  +E  K+  Y+K    CNV          + VF   W   RL ++P K+++       + ++GV++ Q
Sbjct:  113 IQRWFRRRRNQNKSDVLTKFKESGWRFVYYLSIFLIGCWVL--SDQEFIWD-AKKMWINVPFVN------ITPYMFWYIMIELGYYWASLF-TVFFDVKRKDFWEMLIHHLVTIFLICMAWLQNFIGVSMFVLCLHDFVDYFMEAAKMLHYIKQNIICNVL---------FTVFTVAWFVSRLVIFPTKIIYSAFAHIGLGHFGVHLCQ 302
[Close]
BLAST of TLC domain-containing protein vs. Planmine SMEST
Match: SMESG000039123.1 (SMESG000039123.1)

HSP 1 Score: 67.3958 bits (163), Expect = 7.918e-12
Identity = 55/187 (29.41%), Postives = 92/187 (49.20%), Query Frame = 2 
Query:  365 LSKWLRVR----PSDI-SKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYP 910
            + +W R R     SD+ +KF ES W+ + Y + + +  +V+  S    I+    ++W  + F N      I   ++W  + +LG+Y  S+F T+  D  R D   +++HH++T FLI  +++  +  V M VL LHD  D  +E  K+  Y+K    CNV          + VF   W   RL ++P
Sbjct:  113 IQRWFRRRRNQNKSDVLTKFKESGWRFVYYLSIFLIGCWVL--SDQEFIWD-AKKMWINVPFVN------ITPYMFWYIMIELGYYWASLF-TVFFDVKRKDFWEMLIHHLVTIFLICMAWLQNFIGVSMFVLCLHDFVDYFMEAAKMLHYIKQNIICNVL---------FTVFTVAWFVSRLVIFP 280
[Close]
BLAST of TLC domain-containing protein vs. Planmine SMEST
Match: SMESG000039123.1 (SMESG000039123.1)

HSP 1 Score: 66.2402 bits (160), Expect = 1.073e-11
Identity = 55/187 (29.41%), Postives = 92/187 (49.20%), Query Frame = 2 
Query:  365 LSKWLRVR----PSDI-SKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDILKTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLIGFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCANSGYVVFVSVWAWFRLYLYP 910
            + +W R R     SD+ +KF ES W+ + Y + + +  +V+  S    I+    ++W  + F N      I   ++W  + +LG+Y  S+F T+  D  R D   +++HH++T FLI  +++  +  V M VL LHD  D  +E  K+  Y+K    CNV          + VF   W   RL ++P
Sbjct:  113 IQRWFRRRRNQNKSDVLTKFKESGWRFVYYLSIFLIGCWVL--SDQEFIWD-AKKMWINVPFVN------ITPYMFWYIMIELGYYWASLF-TVFFDVKRKDFWEMLIHHLVTIFLICMAWLQNFIGVSMFVLCLHDFVDYFMEAAKMLHYIKQNIICNVL---------FTVFTVAWFVSRLVIFP 280
The following BLAST results are available for this feature:
BLAST of TLC domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CERS18.374e-4433.14ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
CERS11.137e-4236.23ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
CERS11.465e-3637.92ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
CERS17.371e-3237.68ceramide synthase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
CERS61.686e-1429.15ceramide synthase 6 [Source:HGNC Symbol;Acc:HGNC:2... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lagr-17.177e-2831.58Probable ceramide synthase lagr-1 [Source:UniProt... [more]
hyl-11.632e-1134.43Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-P... [more]
hyl-13.470e-1134.43Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-P... [more]
hyl-13.470e-1134.43Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-P... [more]
hyl-13.610e-1134.43Ceramide synthase hyl-1 [Source:UniProtKB/Swiss-P... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
schlank2.834e-1329.52gene:FBgn0040918 transcript:FBtr0070938[more]
schlank2.834e-1329.52gene:FBgn0040918 transcript:FBtr0070937[more]
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BLAST of TLC domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cers11.381e-5137.83ceramide synthase 1 [Source:ZFIN;Acc:ZDB-GENE-0502... [more]
cers12.388e-5037.75ceramide synthase 1 [Source:ZFIN;Acc:ZDB-GENE-0502... [more]
cers63.038e-1529.90ceramide synthase 6 [Source:ZFIN;Acc:ZDB-GENE-0705... [more]
cers4a4.525e-1527.84ceramide synthase 4a [Source:ZFIN;Acc:ZDB-GENE-020... [more]
cers62.923e-1429.38ceramide synthase 6 [Source:ZFIN;Acc:ZDB-GENE-0705... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000022338.16.689e-4732.92ceramide synthase 1 [Source:NCBI gene;Acc:10048512... [more]
cers31.174e-1528.14ceramide synthase 3 [Source:NCBI gene;Acc:448139][more]
cers31.326e-1528.00ceramide synthase 3 [Source:NCBI gene;Acc:448139][more]
ENSXETT00000051557.14.588e-1428.57pep primary_assembly:Xenopus_tropicalis_v9.1:1:738... [more]
cers21.846e-1329.06ceramide synthase 2 [Source:NCBI gene;Acc:10003672... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cers12.347e-4731.25ceramide synthase 1 [Source:MGI Symbol;Acc:MGI:213... [more]
Cers41.415e-1528.12ceramide synthase 4 [Source:MGI Symbol;Acc:MGI:191... [more]
Cers61.147e-1430.15ceramide synthase 6 [Source:MGI Symbol;Acc:MGI:244... [more]
Cers61.191e-1430.15ceramide synthase 6 [Source:MGI Symbol;Acc:MGI:244... [more]
Cers35.688e-1330.86ceramide synthase 3 [Source:MGI Symbol;Acc:MGI:268... [more]
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BLAST of TLC domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P27545|CERS1_MOUSE1.642e-4631.25Ceramide synthase 1 OS=Mus musculus OX=10090 GN=Ce... [more]
sp|P27544|CERS1_HUMAN4.021e-4333.14Ceramide synthase 1 OS=Homo sapiens OX=9606 GN=CER... [more]
sp|Q9XWE9|LAGR1_CAEEL9.130e-2731.58Probable ceramide synthase lagr-1 OS=Caenorhabditi... [more]
sp|Q5E9R6|CERS4_BOVIN1.004e-1527.30Ceramide synthase 4 OS=Bos taurus OX=9913 GN=CERS4... [more]
sp|Q84QC0|ASCL3_ORYSJ1.363e-1525.21ASC1-like protein 3 OS=Oryza sativa subsp. japonic... [more]
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BLAST of TLC domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267H6D93.268e-8742.90TLC domain-containing protein OS=Macrostomum ligna... [more]
A0A1I8I5B86.381e-8743.41TLC domain-containing protein OS=Macrostomum ligna... [more]
A0A267GW442.915e-8643.73TLC domain-containing protein OS=Macrostomum ligna... [more]
A0A267EDE12.750e-8543.44TLC domain-containing protein OS=Macrostomum ligna... [more]
A0A1I8G8D14.040e-8543.44TLC domain-containing protein OS=Macrostomum ligna... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cers11.401e-5440.39ceramide synthase 1 [Source:ZFIN;Acc:ZDB-GENE-0502... [more]
cers2b5.731e-1629.15ceramide synthase 2b [Source:ZFIN;Acc:ZDB-GENE-110... [more]
cers2b1.791e-1528.06ceramide synthase 2b [Source:ZFIN;Acc:ZDB-GENE-110... [more]
cers62.165e-1532.16ceramide synthase 6 [Source:NCBI gene;Acc:10302846... [more]
cers62.491e-1532.16ceramide synthase 6 [Source:NCBI gene;Acc:10302846... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSPMAT00000009225.11.362e-4041.11pep scaffold:Pmarinus_7.0:GL487342:1832:7642:1 gen... [more]
ENSPMAT00000010799.17.982e-3232.85pep scaffold:Pmarinus_7.0:GL476346:662815:681391:1... [more]
ENSPMAT00000009211.14.849e-1529.90pep scaffold:Pmarinus_7.0:GL476916:175486:192535:1... [more]
cers66.406e-1427.81ceramide synthase 6 [Source:ZFIN;Acc:ZDB-GENE-0705... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
LAC14.146e-625.34Ceramide synthase component; involved in synthesis... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO498667.568e-4543.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO400476.117e-1230.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO438741.449e-927.45Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TLC domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cers19.454e-5334.41ceramide synthase 1 [Source:NCBI gene;Acc:10116646... [more]
cers53.514e-1429.31ceramide synthase 5 [Source:NCBI gene;Acc:10117523... [more]
cers4a3.760e-1431.02ceramide synthase 2 [Source:NCBI gene;Acc:10117563... [more]
cers2a1.471e-1328.02ceramide synthase 2 [Source:NCBI gene;Acc:10116285... [more]
cers2b4.689e-1328.72ceramide synthase 2-like [Source:NCBI gene;Acc:101... [more]
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BLAST of TLC domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000057441.10.000e+099.48SMESG000057441.1[more]
SMESG000039123.15.060e-1328.23SMESG000039123.1[more]
SMESG000039123.17.918e-1229.41SMESG000039123.1[more]
SMESG000039123.11.073e-1129.41SMESG000039123.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30035150 ID=SMED30035150|Name=TLC domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1816bp
AAGTACTTCAATAAACAATTTTAAATTAGTTGCATTGACATTGTCAGTTT
TGATAAAAATAATTTTATTACGAAAGTTTATTAAAAATTGATTTCAAATA
ATGCTTTCTCAAGAAGAAATTATTTATGCCAAATCTTTGGAGCAATACTG
CGATGATCCACTACCAACCTATTTTGAATTCATTAACAAAACATGGATTT
CCTTTCAAGAATTTGGTCTAAATTTTACTCGGTACCCATGTGACTATTAT
TTTACACTTGAAATAATCAATGCCATCAAGATTTCTGATGTGGCAACTGT
CCTTTTCATTGCACTCCTTTTTACAATAACCAGGATATCTACAACGAAAT
TGTTGTTAAATCCATTAAGTAAATGGTTACGAGTCAGACCATCTGATATT
TCTAAATTTAATGAATCAGTATGGAAAACAATGGTATATGCCACTTTTTG
GTCGCTGACGAGGTATGTCATCATTACTAGTGGCAATTACACCATTTATC
AATACCCTCTTCGAATATGGAAAGGTTTAACTTTCACAAATGATATCCTT
AAAACGGATATTCCTAGCGACATATATTGGCTTTACGTATTCCAGCTCGG
GTTTTATATTCATTCGATATTTGCTACTCTAAAATTAGATGCATGGCGGA
CTGATTCCAACATGCTCGTTTTGCATCATATATTAACGACTTTCCTGATA
GGTTTCTCATTTATTATGCGATACCACATGGTTGGTATGCTCGTACTTTA
TCTTCATGACATTGCAGATGTCATTTTGGAGTTTACTAAAGTCAATGTCT
ACTTGAAATCACGCCCTGATTGCAATGTAACCATTAATCAGTTTTGCGCC
AATAGCGGATACGTCGTATTCGTTTCTGTTTGGGCTTGGTTCAGACTCTA
TTTATATCCTTTGAAAGTCCTACATGTCACTAATTGGGGAGTTTATATCA
CACAGATTGGAAAAGATCCGAAAATGTATTTGTTCTTCAATAGCATGCTG
CTGATGCTGTTGTTCCTGAATTTTTATTGGTTTTATATCTGTATAAAGCT
CGGTTACAAAATCGCAAGCGGACAAATGTCAGGAGTTGAAGATGTTCGAG
AATTGGAGGAGGAAATCTCATCAATGAAAAACCAATCAAATCATAATCCC
GGGTCTTCCAAATCAGATACACTAAAGAACGGCATTCAGAACGGAGTGTG
CAACATGAATAAATTGTCGGCATCTACGTCTAACAGTAACAGCAAGAAAG
AAATGTGAATAAATAATAATTTTATGATAATTTATGGGCGCAAATTTATG
ATTTCACTATATAATATTATTATTATTATATCTATTATTTCATTGTGTTG
CCTGGAATTTTAATTTTGATGTCGATTTTGATCTTTTTTTGTTAAATAAA
GTAATTTTTGGTATTAGGCACATTTTTTGAGATATGCTATAATGGTTATC
GTCGTGGTCGTTTTGTAATTCCTTGAATAAATATGATGCCTAAATAAATA
TATTACGCAATTATAACCGTCAGTGATTGGCTGCTGCCTTTGATTTGATT
TCCTATATGTGTATGCCAATGCGGTTCAGAATTTTCATTGATTTCAGGTA
AATATATATGATACCGTTTTGAGTAATTAAATTTGAAAACTTTGTTGTAT
TGGCAGCGTGCCACATGTTTGTGTGTGCTGTTGCTGGTGCTTAATCGCTT
CACAGATTAATGAATGCATTACAAGACTCAATAACTTTATGCCAATAATA
ATGTGTCTGTTGTAGTCAGTGAAAACGACTAATTTTATATAATTACTGTC
TATTAAAGCAAGATCG
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protein sequence of SMED30035150-orf-1

>SMED30035150-orf-1 ID=SMED30035150-orf-1|Name=SMED30035150-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=386bp
MLSQEEIIYAKSLEQYCDDPLPTYFEFINKTWISFQEFGLNFTRYPCDYY
FTLEIINAIKISDVATVLFIALLFTITRISTTKLLLNPLSKWLRVRPSDI
SKFNESVWKTMVYATFWSLTRYVIITSGNYTIYQYPLRIWKGLTFTNDIL
KTDIPSDIYWLYVFQLGFYIHSIFATLKLDAWRTDSNMLVLHHILTTFLI
GFSFIMRYHMVGMLVLYLHDIADVILEFTKVNVYLKSRPDCNVTINQFCA
NSGYVVFVSVWAWFRLYLYPLKVLHVTNWGVYITQIGKDPKMYLFFNSML
LMLLFLNFYWFYICIKLGYKIASGQMSGVEDVRELEEEISSMKNQSNHNP
GSSKSDTLKNGIQNGVCNMNKLSASTSNSNSKKEM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
Vocabulary: INTERPRO
TermDefinition
IPR016439Lag1/Lac1-like
IPR006634TLC-dom
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0005783endoplasmic reticulum
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006634TRAM/LAG1/CLN8 homology domainSMARTSM00724lag1_27coord: 101..323
e-value: 1.6E-25
score: 100.8
IPR006634TRAM/LAG1/CLN8 homology domainPFAMPF03798TRAM_LAG1_CLN8coord: 102..315
e-value: 1.6E-29
score: 103.1
IPR006634TRAM/LAG1/CLN8 homology domainPROSITEPS50922TLCcoord: 90..323
score: 12.051
IPR016439Sphingosine N-acyltransferase Lag1/Lac1-likePIRSFPIRSF005225LAG1_LAC1coord: 15..362
e-value: 4.4E-58
score: 195.2
IPR016439Sphingosine N-acyltransferase Lag1/Lac1-likePANTHERPTHR12560LONGEVITY ASSURANCE FACTOR 1 LAG1coord: 18..349
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 340..360
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 342..360
NoneNo IPR availablePANTHERPTHR12560:SF20CERAMIDE SYNTHASE 1coord: 18..349
NoneNo IPR availableTMHMMTMhelixcoord: 294..313
NoneNo IPR availableTMHMMTMhelixcoord: 158..177
NoneNo IPR availableTMHMMTMhelixcoord: 260..282
NoneNo IPR availableTMHMMTMhelixcoord: 55..77
NoneNo IPR availableTMHMMTMhelixcoord: 189..211