WD repeat domain phosphoinositide-interacting protein 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30035095 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Human
Match: WIPI2 (WD repeat domain, phosphoinositide interacting 2 [Source:HGNC Symbol;Acc:HGNC:32225]) HSP 1 Score: 248.825 bits (634), Expect = 2.042e-76 Identity = 152/443 (34.31%), Postives = 226/443 (51.02%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKS-------NQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + E+ + + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T + P V + + + +D L + DE +S L + +++E PP+
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEP------------------------TTWTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDE---ASALRLDEDSEHPPM 420
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Human
Match: WIPI2 (WD repeat domain, phosphoinositide interacting 2 [Source:HGNC Symbol;Acc:HGNC:32225]) HSP 1 Score: 243.432 bits (620), Expect = 2.412e-74 Identity = 155/454 (34.14%), Postives = 233/454 (51.32%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL------SNEKHITKSNQPPVL---------ENKSLDSMNSR---SDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + E+ + + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L +NE + S+ P++ + + S +R +D L + DE +S L + +++E PP+
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEP------------------------TTWTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDE---ASALRLDEDSEHPPM 431
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Human
Match: WIPI2 (WD repeat domain, phosphoinositide interacting 2 [Source:HGNC Symbol;Acc:HGNC:32225]) HSP 1 Score: 239.195 bits (609), Expect = 1.632e-72 Identity = 148/434 (34.10%), Postives = 222/434 (51.15%), Query Frame = 3
Query: 78 SILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKS-------NQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + E+ + P + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T + P V + + + +D L + DE +S L + +++E PP+
Sbjct: 44 SLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEE--PTT----------------------WTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDE---ASALRLDEDSEHPPM 438
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Human
Match: WIPI2 (WD repeat domain, phosphoinositide interacting 2 [Source:HGNC Symbol;Acc:HGNC:32225]) HSP 1 Score: 232.646 bits (592), Expect = 8.043e-71 Identity = 139/399 (34.84%), Postives = 204/399 (51.13%), Query Frame = 3
Query: 177 VGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKS-------NQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + E+ + + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T + P V + + + +D L + DE +S L + +++E PP+
Sbjct: 20 VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEP------------------------TTWTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPFC---------GHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDE---ASALRLDEDSEHPPM 379
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Human
Match: WIPI2 (WD repeat domain, phosphoinositide interacting 2 [Source:HGNC Symbol;Acc:HGNC:32225]) HSP 1 Score: 233.802 bits (595), Expect = 2.280e-70 Identity = 150/445 (33.71%), Postives = 228/445 (51.24%), Query Frame = 3
Query: 78 SILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL------SNEKHITKSNQPPVL---------ENKSLDSMNSR---SDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + E+ + + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L +NE + S+ P++ + + S +R +D L + DE +S L + +++E PP+
Sbjct: 44 SLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEP------------------------TTWTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDE---ASALRLDEDSEHPPM 449
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Celegans
Match: atg-18 (AuTophaGy (Yeast Atg homolog) [Source:UniProtKB/TrEMBL;Acc:H2KYN5]) HSP 1 Score: 243.047 bits (619), Expect = 7.435e-75 Identity = 142/446 (31.84%), Postives = 238/446 (53.36%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIY---GIEMDKVIQKESNKIIPI-----MKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFAL-SNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
+++N+IGFNQD + I +G+ +GY Y I + + E + + + + RL++S+L+V +S DPR L ++H +I + +F+ S+L+V+LNR +VVC ED IYIY+ ++MK H + P+N+ G+ L SN ++++AYP + TG+VH+F+ + +V AH+G IA L+FNQ + +ATAS KGTVIR++ +P+G + EFRRG RC I L FS +S++L SNTETVHVF + + DNK G WF+ + A +P QV E+ + +R F+ A+LP +S+ ++H+ + ++ AT DGF+Y ++ D E GGE +LI +++ + ++++ + S + + S+ N+D D ++FPP+
Sbjct: 11 DSINYIGFNQDSKVICVGHKDGYMFYKTADILENNTLTYEGENLTHLGLNNCLIIERLFSSALMVVISQKDPRVLHVYHFTSRNIICDHRFNKSVLTVRLNRDRIVVCLEDCIYIYNLKDMKMMHNIMDTPTNKLGVLDLTSNPGNALIAYPGSTDTGSVHLFDAINLSSVSTFNAHEGTIACLKFNQEGNMIATASTKGTVIRVYSVPNGHRLFEFRRGVTRCVNIYSLCFSSDSKYLTSSSNTETVHVFKLEKTEGVDNKPEASTEGGG-------------------WFDAINKTFSA---YMPSQVLQVGELMTTERSFATAKLPGAARSNQVSLVSHK---------NQQYVMAATSDGFVYAYRLDPE-GGELDLIKQHNIGPKSDTSRASPTSTGSGGAAKSAEASNQSV---------------PNMD--DPDDFPPM 407
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Celegans
Match: atg-18 (AuTophaGy (Yeast Atg homolog) [Source:UniProtKB/TrEMBL;Acc:H2KYN5]) HSP 1 Score: 242.276 bits (617), Expect = 9.237e-75 Identity = 134/382 (35.08%), Postives = 214/382 (56.02%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIY---GIEMDKVIQKESNKIIPI-----MKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFAL-SNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELI 1157
+++N+IGFNQD + I +G+ +GY Y I + + E + + + + RL++S+L+V +S DPR L ++H +I + +F+ S+L+V+LNR +VVC ED IYIY+ ++MK H + P+N+ G+ L SN ++++AYP + TG+VH+F+ + +V AH+G IA L+FNQ + +ATAS KGTVIR++ +P+G + EFRRG RC I L FS +S++L SNTETVHVF + + DNK G WF+ + A +P QV E+ + +R F+ A+LP +S+ ++H+ + ++ AT DGF+Y ++ D E GGE +LI
Sbjct: 11 DSINYIGFNQDSKVICVGHKDGYMFYKTADILENNTLTYEGENLTHLGLNNCLIIERLFSSALMVVISQKDPRVLHVYHFTSRNIICDHRFNKSVLTVRLNRDRIVVCLEDCIYIYNLKDMKMMHNIMDTPTNKLGVLDLTSNPGNALIAYPGSTDTGSVHLFDAINLSSVSTFNAHEGTIACLKFNQEGNMIATASTKGTVIRVYSVPNGHRLFEFRRGVTRCVNIYSLCFSSDSKYLTSSSNTETVHVFKLEKTEGVDNKPEASTEGGG-------------------WFDAINKTFSA---YMPSQVLQVGELMTTERSFATAKLPGAARSNQVSLVSHK---------NQQYVMAATSDGFVYAYRLDPE-GGELDLI 360
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Celegans
Match: epg-6 (Ectopic P Granules [Source:UniProtKB/TrEMBL;Acc:E3CTH5]) HSP 1 Score: 78.9518 bits (193), Expect = 1.407e-15 Identity = 73/290 (25.17%), Postives = 136/290 (46.90%), Query Frame = 3
Query: 27 TMQLNAVNFIGFNQDYQSILMGNSNGYTIYGIE-------MDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRK-----LTLFHHKRNAVIIEVKFSN---SILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS---NSDHSILAYPSTNMTGNVHVFNI-----AEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGN 827
T ++ +N D+ + + + +G+ +Y + D VI K+ P+ V + NS +++VS + L +F RN E+ + I ++ ++ +V + ++++ + ++ + E SN GI A+S + LAYP TG+V + ++ E K+ ++IEAH IA + N +AT S KGTVIR+F + E RRG + A + C++FS S +L V S+ T+H+F +++ E K ++ + G+
Sbjct: 30 TEEMTTLNHASVTLDHSAFAIADKDGFKMYQLNPLHFRMYKDYVI-----KVGPVRLVKQDGNSRRIIYVSALAGGRFAQNNLMIFDVARNEEYFEITTPSRYGPITNIHVSPNRLVALNPNRMFVWTYPDDIKQIRSEDIRSNPKGISAMSYDPTTAACYLAYPGFK-TGSVQIMHLNALTARESKSPIVIEAHLTDIAQVALNCQGTLVATGSTKGTVIRVFDARTKGPLYELRRGTVQ-AHLQCMAFSPCSSYLAVASDKGTLHMFG-IRDAEPQKKKNVLERSRGS 311
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Celegans
Match: epg-6 (Ectopic P Granules [Source:UniProtKB/TrEMBL;Acc:E3CTH5]) HSP 1 Score: 78.9518 bits (193), Expect = 1.414e-15 Identity = 73/290 (25.17%), Postives = 136/290 (46.90%), Query Frame = 3
Query: 27 TMQLNAVNFIGFNQDYQSILMGNSNGYTIYGIE-------MDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRK-----LTLFHHKRNAVIIEVKFSN---SILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS---NSDHSILAYPSTNMTGNVHVFNI-----AEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGN 827
T ++ +N D+ + + + +G+ +Y + D VI K+ P+ V + NS +++VS + L +F RN E+ + I ++ ++ +V + ++++ + ++ + E SN GI A+S + LAYP TG+V + ++ E K+ ++IEAH IA + N +AT S KGTVIR+F + E RRG + A + C++FS S +L V S+ T+H+F +++ E K ++ + G+
Sbjct: 30 TEEMTTLNHASVTLDHSAFAIADKDGFKMYQLNPLHFRMYKDYVI-----KVGPVRLVKQDGNSRRIIYVSALAGGRFAQNNLMIFDVARNEEYFEITTPSRYGPITNIHVSPNRLVALNPNRMFVWTYPDDIKQIRSEDIRSNPKGISAMSYDPTTAACYLAYPGFK-TGSVQIMHLNALTARESKSPIVIEAHLTDIAQVALNCQGTLVATGSTKGTVIRVFDARTKGPLYELRRGTVQ-AHLQCMAFSPCSSYLAVASDKGTLHMFG-IRDAEPQKKKNVLERSRGS 311
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Celegans
Match: epg-6 (Ectopic P Granules [Source:UniProtKB/TrEMBL;Acc:E3CTH5]) HSP 1 Score: 76.6406 bits (187), Expect = 5.447e-15 Identity = 72/287 (25.09%), Postives = 134/287 (46.69%), Query Frame = 3
Query: 36 LNAVNFIGFNQDYQSILMGNSNGYTIYGIE-------MDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRK-----LTLFHHKRNAVIIEVKFSN---SILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS---NSDHSILAYPSTNMTGNVHVFNI-----AEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGN 827
+ +N D+ + + + +G+ +Y + D VI K+ P+ V + NS +++VS + L +F RN E+ + I ++ ++ +V + ++++ + ++ + E SN GI A+S + LAYP TG+V + ++ E K+ ++IEAH IA + N +AT S KGTVIR+F + E RRG + A + C++FS S +L V S+ T+H+F +++ E K ++ + G+
Sbjct: 1 MTTLNHASVTLDHSAFAIADKDGFKMYQLNPLHFRMYKDYVI-----KVGPVRLVKQDGNSRRIIYVSALAGGRFAQNNLMIFDVARNEEYFEITTPSRYGPITNIHVSPNRLVALNPNRMFVWTYPDDIKQIRSEDIRSNPKGISAMSYDPTTAACYLAYPGFK-TGSVQIMHLNALTARESKSPIVIEAHLTDIAQVALNCQGTLVATGSTKGTVIRVFDARTKGPLYELRRGTVQ-AHLQCMAFSPCSSYLAVASDKGTLHMFG-IRDAEPQKKKNVLERSRGS 279
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Fly
Match: Atg18a (gene:FBgn0035850 transcript:FBtr0321321) HSP 1 Score: 224.172 bits (570), Expect = 5.105e-68 Identity = 131/385 (34.03%), Postives = 206/385 (53.51%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGI-----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKH 1187
F+ FNQ+ S+ + S GY++Y + +DK+ +S+++ I RL+ SSLV VS PRKL + H K+ + I ++N+IL+VKLNR+ ++VC E+ +YI++ ++MK H + P N G+ ALS+S +H LAYP + G V +F+ + +I AH +AAL F+ +ATAS++GTVIR+F G + E RRG RC +I LSFS +++L+ SNTETVH+F + D + G+K + +W ++ K TS LP QVT++FSQ R F+ LP R++ A+ R+++A+ DG++Y++ G E +LI +DL E H
Sbjct: 16 FVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLI---ERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRL------DRSATETAEGHGSKQS------------SDDWMGFLS---KTVTSYLP---TQVTDVFSQGRAFASVTLPEAGV---------RRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDH 364
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Fly
Match: Atg18a (gene:FBgn0035850 transcript:FBtr0321319) HSP 1 Score: 223.787 bits (569), Expect = 3.775e-67 Identity = 129/385 (33.51%), Postives = 207/385 (53.77%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGI-----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKH 1187
F+ FNQ+ S+ + S GY++Y + +DK+ +S+++ I RL+ SSLV VS PRKL + H K+ + I ++N+IL+VKLNR+ ++VC E+ +YI++ ++MK H + P N G+ ALS+S +H LAYP + G V +F+ + +I AH +AAL F+ +ATAS++GTVIR+F G + E RRG RC +I LSFS +++L+ SNTETVH+F + ++ A ++ + +W ++ K TS LP QVT++FSQ R F+ LP + R++ A+ R+++A+ DG++Y++ G E +LI +DL E H
Sbjct: 16 FVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLIE---RLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRL------------------DRSATETAEGHGSKQSSDDWMGFLS---KTVTSYLP---TQVTDVFSQGRAFASVTLP---------EAGVRRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDH 364
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Fly
Match: Atg18a (gene:FBgn0035850 transcript:FBtr0076691) HSP 1 Score: 221.476 bits (563), Expect = 6.213e-67 Identity = 132/387 (34.11%), Postives = 205/387 (52.97%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGI-----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSAL--KATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKH 1187
F+ FNQ+ S+ + S GY++Y + +DK+ +S+++ I RL+ SSLV VS PRKL + H K+ + I ++N+IL+VKLNR+ ++VC E+ +YI++ ++MK H + P N G+ ALS+S +H LAYP + G V +F+ + +I AH +AAL F+ +ATAS++GTVIR+F G + E RRG RC +I LSFS +++L+ SNTETVH+F + D + G+K + +W Y K TS LP QVT++FSQ R F+ LP R++ A+ R+++A+ DG++Y++ G E +LI +DL E H
Sbjct: 16 FVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLI---ERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRL------DRSATETAEGHGSKQS------------SDDWMGYSFFRFLSKTVTSYLP---TQVTDVFSQGRAFASVTLPEAGV---------RRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDH 369
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Fly
Match: Atg18a (gene:FBgn0035850 transcript:FBtr0076692) HSP 1 Score: 221.476 bits (563), Expect = 6.213e-67 Identity = 132/387 (34.11%), Postives = 205/387 (52.97%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGI-----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSAL--KATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKH 1187
F+ FNQ+ S+ + S GY++Y + +DK+ +S+++ I RL+ SSLV VS PRKL + H K+ + I ++N+IL+VKLNR+ ++VC E+ +YI++ ++MK H + P N G+ ALS+S +H LAYP + G V +F+ + +I AH +AAL F+ +ATAS++GTVIR+F G + E RRG RC +I LSFS +++L+ SNTETVH+F + D + G+K + +W Y K TS LP QVT++FSQ R F+ LP R++ A+ R+++A+ DG++Y++ G E +LI +DL E H
Sbjct: 16 FVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLI---ERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRL------DRSATETAEGHGSKQS------------SDDWMGYSFFRFLSKTVTSYLP---TQVTDVFSQGRAFASVTLPEAGV---------RRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDH 369
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Fly
Match: Atg18a (gene:FBgn0035850 transcript:FBtr0346547) HSP 1 Score: 221.476 bits (563), Expect = 6.213e-67 Identity = 132/387 (34.11%), Postives = 205/387 (52.97%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGI-----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSAL--KATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKH 1187
F+ FNQ+ S+ + S GY++Y + +DK+ +S+++ I RL+ SSLV VS PRKL + H K+ + I ++N+IL+VKLNR+ ++VC E+ +YI++ ++MK H + P N G+ ALS+S +H LAYP + G V +F+ + +I AH +AAL F+ +ATAS++GTVIR+F G + E RRG RC +I LSFS +++L+ SNTETVH+F + D + G+K + +W Y K TS LP QVT++FSQ R F+ LP R++ A+ R+++A+ DG++Y++ G E +LI +DL E H
Sbjct: 16 FVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLI---ERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRL------DRSATETAEGHGSKQS------------SDDWMGYSFFRFLSKTVTSYLP---TQVTDVFSQGRAFASVTLPEAGV---------RRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDH 369
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Zebrafish
Match: wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:ZFIN;Acc:ZDB-GENE-040718-488]) HSP 1 Score: 246.899 bits (629), Expect = 6.602e-76 Identity = 154/443 (34.76%), Postives = 227/443 (51.24%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL------SNE-KHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS ++D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM +L SNTETVH+F + +R+ P + W Y G L A+T+ LP VTE+F+Q R F+ RLP + H+ + A+ R++VA DG++Y++ D + GGE L+ + L +NE T ++P V + S S+ + D D + L + +ENE PP+
Sbjct: 17 FANFNQDNTSLAVGTKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSISNDNCYLAYPGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMEGLYLSASSNTETVHIFKL--ETQREKPQEEPTT----------------------WTGYFGKVLMASTTYLP---AHVTEMFTQGRAFATVRLPFS---------GHKNICALAIIQKIPRLLVAAADGYLYLYNLDPQEGGECTLMKQHKLDGSAEPANEILEQTAHDRPLVAQTYSAAVAKGYSEDQGAVGGAGVED---DMNTLHLDEENEQPPL 420
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Zebrafish
Match: wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:ZFIN;Acc:ZDB-GENE-040718-488]) HSP 1 Score: 215.312 bits (547), Expect = 3.292e-65 Identity = 128/343 (37.32%), Postives = 182/343 (53.06%), Query Frame = 3
Query: 90 GNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFI 1109
G +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS S D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM +L SNTETVH+F + E + S+P + W Y G L A+T+ LP VTE+F+Q R F+ RLP + H+ + A+ R++VA DG++
Sbjct: 2 GTKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSISNDNCYLAYPGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMEGLYLSASSNTETVHIFKL----ETQREKSVPQEE------------------PTTWTGYFGKVLMASTTYLP---AHVTEMFTQGRAFATVRLPFS---------GHKNICALAIIQKIPRLLVAAADGYL 310
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Zebrafish
Match: wipi1 (WD repeat domain, phosphoinositide interacting 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1404]) HSP 1 Score: 214.157 bits (544), Expect = 3.520e-63 Identity = 151/451 (33.48%), Postives = 231/451 (51.22%), Query Frame = 3
Query: 60 FNQDYQSILMGNSNGYTIYGI-EMDKV-IQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL-SNEKHITKSNQPPVLENKS-----------------LDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
FNQD S+ +G GY ++ + +DK+ ES + + V RL++SSLVV VS PR++ ++H K+ I +SN+IL+V+LNR+ +VVC E+ IYI++ ++MK + PSN G+ ALS N +S LAYP ++ G + V++ + V +I AH +AA+ F+ LA+AS++GTVIR+F IP G + EFRRG R IS LSFS ++QFL SNTETVH+F + Q +S G ++A +W YVG A +S LP QV+ + SQDR F+ RL Q R V A+ R++VA+ DG ++I+ D + GGE L+ + L ++K ++NQ + E ++ S+ + + + + + DE EFPPI
Sbjct: 24 FNQDSTSLAVGTKTGYRLFSVTSVDKLDCIHESAETPEVYIVERLFSSSLVVVVSQSMPRRMNVYHFKKGTEICNYSYSNNILAVRLNRQRLVVCLEESIYIHNIKDMKLLKTLLNTPSNPSGLCALSINHSNSFLAYPGSDTIGEIIVYDANNLSTVTMIPAHDSPLAAITFSASGTKLASASERGTVIRVFSIPEGLRLFEFRRGMKRYVNISSLSFSPDAQFLCASSNTETVHIFKLEQ-----------HSPSGEEEA-------------PSWSAYVGKMFTAASSYLP---AQVSGMMSQDRAFATVRLQMAGQ---------RNVCALATIQKLPRLLVASSDGQLFIYNIDPQDGGECTLVQKHRLFGSDKEWEETNQSDMTEAPQACQSYAATVAIPTSGPVTATLTGYSEDGGAKKGEVIPEHEFAAGPVCLDDETEFPPI 438
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Zebrafish
Match: wdr45b (WD repeat domain 45B [Source:NCBI gene;Acc:393210]) HSP 1 Score: 116.701 bits (291), Expect = 2.163e-28 Identity = 80/271 (29.52%), Postives = 147/271 (54.24%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIP--IMKVGRLYNSSLVVFVSTDD-----PRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYD-TENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEM-KNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNL 821
N + + GFNQD+ G NG+ +Y D + +KE + + + V L+ + + V P K+ ++ + +IE++FS + +VKL R +VV + I ++ T N + H E N G+ L NS++S+LA+P+T+ +G+V + ++A K V I AH+G + + N +ATAS+KGT+IR+F +G E RRG ++ A I C++F+ ++ + V S+ TVH+F+ ++ +R+ + S+ +++
Sbjct: 11 NGLLYAGFNQDHGCFACGMENGFRVY--NTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETC-YNPKGLCVLCPNSNNSLLAFPATH-SGHVQIVDLANTEKPPVDIPAHEGVLCCITLNLQGTRIATASEKGTLIRIFDTSAGQLIQELRRG-SQTANIYCINFNQDASLICVSSDHGTVHIFA-AEDPKRNKQSSLASASF 275
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Zebrafish
Match: wdr45 (WD repeat domain 45 [Source:NCBI gene;Acc:393200]) HSP 1 Score: 101.679 bits (252), Expect = 3.849e-23 Identity = 77/268 (28.73%), Postives = 128/268 (47.76%), Query Frame = 3
Query: 33 QLNAVNFIGFNQDYQSILMGNSNGYTIYGIE--MDKVIQKESNKIIPIMKVGRLYNSSLVVFVST--------------DDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMK-----NVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSM 770
Q VN + FNQD G IY +E M+K + ++ I L+ S+L+ V DD R++ ++ +++E F+ +L+V++ +++ ++ IY+Y + K N G+ L S + +L +P + G++ + +++ K I AHQ IA LE NQP +A+AS KGT+IRLF + DK E RRG AT+ C++FS +S FL S+ TVH+F++
Sbjct: 3 QQRGVNSLQFNQDQSCFCCAMETGVRIYNVEPLMEKG-HLDHEQVGSIALCSMLHRSNLLAVVGGGVNPKFSEISVLIWDDAREV---RDPKDKLVLEFTFTKPVLAVRMRHDKIIIILKNRIYVYSFPDNPVKLFEFDTRDNPKGLCDLCPSLEKQLLVFPG-HKCGSLQLVDLSNTKPGTSSAPFTINAHQSEIACLELNQPGSVVASASRKGTLIRLFDTTTRDKLVELRRGTDP-ATLYCINFSHDSSFLCASSDKGTVHIFAL 264
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Xenopus
Match: hacl1 (2-hydroxyacyl-CoA lyase 1 [Source:Xenbase;Acc:XB-GENE-982243]) HSP 1 Score: 251.906 bits (642), Expect = 1.152e-77 Identity = 164/469 (34.97%), Postives = 239/469 (50.96%), Query Frame = 3
Query: 24 QTMQLNAVN--FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPP---VLENKSLD-------------------SMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
Q+ + AV F FNQD S+ +G+ +GY + + +DK+ Q E N + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N ++ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+S FL SNTETVH+F + E+ ++ P S W Y G + A+TS LP QVTE+F+Q R F+ RLP H+ + A+ R++V DG++YI+ FD + GGE L+ ++H N P +LE+ S D + ++ +D L + DE NL + ++NE PP+
Sbjct: 6 QSAEAGAVQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECNDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSINGENCYLAYPGSASIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPSEE--PTS----------------------WTGYFGRVIMASTSYLP---SQVTEMFNQGRAFATVRLPFC---------GHKNICALATIQKIPRLLVGAADGYLYIYNFDPQEGGECTLM-------KQHKLDGNMEPSSEILESSSHDRPVAALTAIVTKTYPPPSPTRHAYADDLGAVGGASEDDEI---RNLRLDEDNENPPM 428
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Xenopus
Match: hacl1 (2-hydroxyacyl-CoA lyase 1 [Source:Xenbase;Acc:XB-GENE-982243]) HSP 1 Score: 243.047 bits (619), Expect = 4.738e-74 Identity = 164/485 (33.81%), Postives = 240/485 (49.48%), Query Frame = 3
Query: 24 QTMQLNAVN--FIGFNQD----------------YQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPP---VLENKSLD-------------------SMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
Q+ + AV F FNQD + S+ +G+ +GY + + +DK+ Q E N + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N ++ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+S FL SNTETVH+F + E+ ++ P S W Y G + A+TS LP QVTE+F+Q R F+ RLP H+ + A+ R++V DG++YI+ FD + GGE L+ ++H N P +LE+ S D + ++ +D L + DE NL + ++NE PP+
Sbjct: 6 QSAEAGAVQLLFANFNQDNTYKRGAGGIGSNRIVWGSLAVGSKSGYKFFSLSSVDKLEQIYECNDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSINGENCYLAYPGSASIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPSEE--PTS----------------------WTGYFGRVIMASTSYLP---SQVTEMFNQGRAFATVRLPFC---------GHKNICALATIQKIPRLLVGAADGYLYIYNFDPQEGGECTLM-------KQHKLDGNMEPSSEILESSSHDRPVAALTAIVTKTYPPPSPTRHAYADDLGAVGGASEDDEI---RNLRLDEDNENPPM 444
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Xenopus
Match: hacl1 (2-hydroxyacyl-CoA lyase 1 [Source:Xenbase;Acc:XB-GENE-982243]) HSP 1 Score: 239.965 bits (611), Expect = 2.699e-73 Identity = 140/365 (38.36%), Postives = 201/365 (55.07%), Query Frame = 3
Query: 72 YQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELI 1157
Y+S+ +G+ +GY + + +DK+ Q E N + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N ++ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+S FL SNTETVH+F + E+ ++ P S W Y G + A+TS LP QVTE+F+Q R F+ RLP H+ + A+ R++V DG++YI+ FD + GGE L+
Sbjct: 8 YRSLAVGSKSGYKFFSLSSVDKLEQIYECNDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSINGENCYLAYPGSASIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPSEE--PTS----------------------WTGYFGRVIMASTSYLP---SQVTEMFNQGRAFATVRLPFC---------GHKNICALATIQKIPRLLVGAADGYLYIYNFDPQEGGECTLM 336
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Xenopus
Match: hacl1 (2-hydroxyacyl-CoA lyase 1 [Source:Xenbase;Acc:XB-GENE-982243]) HSP 1 Score: 184.111 bits (466), Expect = 2.941e-52 Identity = 142/469 (30.28%), Postives = 214/469 (45.63%), Query Frame = 3
Query: 24 QTMQLNAVN--FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPP---VLENKSLD-------------------SMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
Q+ + AV F FNQD S+ +G+ +GY + + +DK+ Q E N + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N ++ LAYP + G V VF+ + + L S TV+ L +G RC +I L+FSM+S FL SNTETVH+F + E+ ++ P S W Y G + A+TS LP QVTE+F+Q R F+ RLP H+ + A+ R++V DG++YI+ FD + GGE L+ ++H N P +LE+ S D + ++ +D L + DE NL + ++NE PP+
Sbjct: 6 QSAEAGAVQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECNDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSINGENCYLAYPGSASIGEVQVFDTVNLVGI---------------------LHVYSTIKTVLGL---------AATLKGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPSEE--PTS----------------------WTGYFGRVIMASTSYLP---SQVTEMFNQGRAFATVRLPFC---------GHKNICALATIQKIPRLLVGAADGYLYIYNFDPQEGGECTLM-------KQHKLDGNMEPSSEILESSSHDRPVAALTAIVTKTYPPPSPTRHAYADDLGAVGGASEDDEI---RNLRLDEDNENPPM 398
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Xenopus
Match: flcn (folliculin [Source:Xenbase;Acc:XB-GENE-1003590]) HSP 1 Score: 115.931 bits (289), Expect = 6.026e-28 Identity = 78/270 (28.89%), Postives = 144/270 (53.33%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIP--IMKVGRLYNSSLVVFVSTDD-----PRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYD-TENMKRKHKVEIAPSNRHGIFALSNSDHSILAYPSTNMTGNVHVFNIAEM-KNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNL 821
N + + GFNQD+ G NG+ +Y D + +KE + + + V L+ + + V P K+ ++ + +IE++FS + +VKL R +VV + I ++ T N + H E + + NS++S+LA+P + TG+V + ++A K V I AH+G ++ + N +ATAS+KGT+IR+F SG E RRG ++ A I C++F+ ++ + V S+ TVH+F+ ++ +R+ + S+ +++
Sbjct: 11 NGLLYAGFNQDHGCFACGMENGFRVY--NTDPLKEKEKQEFLEGGVGYVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGAH-TGHVQIVDLASTEKPPVDIPAHEGILSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRG-SQAANIYCINFNEDASLICVSSDHGTVHIFA-AEDPKRNKQSSLASASF 275
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Mouse
Match: Wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:MGI Symbol;Acc:MGI:1923831]) HSP 1 Score: 248.054 bits (632), Expect = 2.055e-76 Identity = 152/443 (34.31%), Postives = 225/443 (50.79%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKS-------NQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + R+ P + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T + P + + + +D L + DE +S L + +++E PP+
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL--EAVREKPPEEPTT----------------------WTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLATQTYGTAAAKAYTDDLGAVGGACLEDE---ASALRLDEDSEHPPM 420
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Mouse
Match: Wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:MGI Symbol;Acc:MGI:1923831]) HSP 1 Score: 242.662 bits (618), Expect = 4.927e-74 Identity = 142/384 (36.98%), Postives = 203/384 (52.86%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHIT 1193
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + R+ P + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL--EAVREKPPEEPTT----------------------WTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETT 364
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Mouse
Match: Wipi1 (WD repeat domain, phosphoinositide interacting 1 [Source:MGI Symbol;Acc:MGI:1261864]) HSP 1 Score: 231.876 bits (590), Expect = 6.400e-70 Identity = 157/455 (34.51%), Postives = 242/455 (53.19%), Query Frame = 3
Query: 42 AVNFIGFNQDYQSILMGNSNGYTIYGI----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL-------SNEKHITKSNQPPVL-------ENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
A++ FNQD S+ +G GY ++ + ++D+V SN+I + V RL++SSLVV VS PR++ ++H K+ I +S++ILS++LNR+ ++VC E+ IYI++ ++MK V PSN G+ ALS N +S LAYP + TG + +++ +K V I AH+G +AA+ FN LA+AS+KGTVIR+F +P G K EFRRG R TIS L FSM+SQFL SNTETVH+F M D++ P++ W Y+G A T+ LP QV+++ +QDR F+ RL + Q + T +K+ R++VA+ DG +YI+ D + GGE LI + L N+++ + + PP + ++ S+ L + + + + + DENEFPPI
Sbjct: 16 ALSCFSFNQDCTSLAIGTKAGYKLFSLSSVEQLDQV--HGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLDIPSNPTGLCALSINHSNSYLAYPGSQSTGEIVLYDGNSLKTVCTIAAHEGTLAAITFNSSGSKLASASEKGTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEH--LTDSRPEEPST----------------------WSGYMGKMFMAATNYLP---AQVSDMMNQDRAFATGRLNFSGQKNICTLSTIQKLP---------RLLVASSDGHLYIYNLDPQDGGECVLIKTHSLLSSGTTEENKENDLRPSLPPSYAATVARPSTSAASTVPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPI 432
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Mouse
Match: Wipi1 (WD repeat domain, phosphoinositide interacting 1 [Source:MGI Symbol;Acc:MGI:1261864]) HSP 1 Score: 231.491 bits (589), Expect = 8.224e-70 Identity = 156/455 (34.29%), Postives = 242/455 (53.19%), Query Frame = 3
Query: 42 AVNFIGFNQDYQSILMGNSNGYTIYGI----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL-------SNEKHITKSNQPPVL-------ENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
A++ FNQD S+ +G GY ++ + ++D+V SN+I + V RL++SSLVV VS PR++ ++H K+ I +S++ILS++LNR+ ++VC E+ IYI++ ++MK V PSN G+ ALS N +S LAYP + TG + +++ +K V I AH+G +AA+ FN LA+AS+KGTVIR+F +P G K EFRRG R TIS L FSM+SQFL SNTETVH+F M D++ P++ W Y+G A T+ LP QV+++ +QDR F+ RL + Q + T +K+ R++VA+ DG +YI+ D + GGE LI + L N+++ + + PP + ++ S+ L + + + + + DENEFPP+
Sbjct: 16 ALSCFSFNQDCTSLAIGTKAGYKLFSLSSVEQLDQV--HGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLDIPSNPTGLCALSINHSNSYLAYPGSQSTGEIVLYDGNSLKTVCTIAAHEGTLAAITFNSSGSKLASASEKGTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEH--LTDSRPEEPST----------------------WSGYMGKMFMAATNYLP---AQVSDMMNQDRAFATGRLNFSGQKNICTLSTIQKLP---------RLLVASSDGHLYIYNLDPQDGGECVLIKTHSLLSSGTTEENKENDLRPSLPPSYAATVARPSTSAASTVPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPV 432
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Mouse
Match: Wipi1 (WD repeat domain, phosphoinositide interacting 1 [Source:MGI Symbol;Acc:MGI:1261864]) HSP 1 Score: 191.045 bits (484), Expect = 4.068e-56 Identity = 111/255 (43.53%), Postives = 161/255 (63.14%), Query Frame = 3
Query: 42 AVNFIGFNQDYQSILMGNSNGYTIYGI----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERD 791
A++ FNQD S+ +G GY ++ + ++D+V SN+I + V RL++SSLVV VS PR++ ++H K+ I +S++ILS++LNR+ ++VC E+ IYI++ ++MK V PSN G+ ALS N +S LAYP + TG + +++ +K V I AH+G +AA+ FN LA+AS+KGTVIR+F +P G K EFRRG R TIS L FSM+SQFL SNTETVH+F M +R
Sbjct: 16 ALSCFSFNQDCTSLAIGTKAGYKLFSLSSVEQLDQV--HGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLDIPSNPTGLCALSINHSNSYLAYPGSQSTGEIVLYDGNSLKTVCTIAAHEGTLAAITFNSSGSKLASASEKGTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEHLTDRQ 268
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q5ZHN3|WIPI2_CHICK (WD repeat domain phosphoinositide-interacting protein 2 OS=Gallus gallus OX=9031 GN=WIPI2 PE=2 SV=1) HSP 1 Score: 245.743 bits (626), Expect = 2.033e-74 Identity = 154/454 (33.92%), Postives = 233/454 (51.32%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL------SNEKHITKSNQPPVLEN------------KSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + E+ + + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + A+ R++V DG++Y++ D + GGE L+ + L +NE + S+ P++ S + ++ ++ L + DET ++L + +++E PP+
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPQEEP------------------------TTWTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICALATIQKIPRLLVGAADGYLYMYNLDPQEGGECTLMKQHKLDGSMEPANEILESASHDRPLVAQTYSAAVTKGTYVPSSPTRHAYTEDLGAVGGACLEDET---NSLRLDEDSEHPPM 431
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q7ZWU5|WIPI2_XENLA (WD repeat domain phosphoinositide-interacting protein 2 OS=Xenopus laevis OX=8355 GN=wipi2 PE=2 SV=1) HSP 1 Score: 244.588 bits (623), Expect = 5.142e-74 Identity = 157/459 (34.20%), Postives = 232/459 (50.54%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL--------------SNEKH---------ITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+ L+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ +LS N ++ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+S FL SNTETVH+F + E+ + P S W Y G + A+TS LP QVTE+F+Q R F+ RLP H+ + A+ R++V DG++YI+ FD + GGE L+ + L S+++ +TK+ PP + ++ +D L + DE NL + ++NE PP+
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTTLAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCSLSINGENCYLAYPGSASIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPPEE--PTS----------------------WTGYFGRVIMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICALATIQKISRLLVGAADGYLYIYNFDPQEGGECTLMKQHKLDGSMEPSSEILESSSHDRQVGAQTYSATVTKTYPPPS------PTRHAYADDLGAVGGASEEDEM---GNLRLDEDNENPPM 430
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. UniProt/SwissProt
Match: sp|O16466|ATG18_CAEEL (Autophagy-related protein 18 OS=Caenorhabditis elegans OX=6239 GN=atg-18 PE=1 SV=1) HSP 1 Score: 243.047 bits (619), Expect = 9.458e-74 Identity = 142/446 (31.84%), Postives = 238/446 (53.36%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIY---GIEMDKVIQKESNKIIPI-----MKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFAL-SNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
+++N+IGFNQD + I +G+ +GY Y I + + E + + + + RL++S+L+V +S DPR L ++H +I + +F+ S+L+V+LNR +VVC ED IYIY+ ++MK H + P+N+ G+ L SN ++++AYP + TG+VH+F+ + +V AH+G IA L+FNQ + +ATAS KGTVIR++ +P+G + EFRRG RC I L FS +S++L SNTETVHVF + + DNK G WF+ + A +P QV E+ + +R F+ A+LP +S+ ++H+ + ++ AT DGF+Y ++ D E GGE +LI +++ + ++++ + S + + S+ N+D D ++FPP+
Sbjct: 11 DSINYIGFNQDSKVICVGHKDGYMFYKTADILENNTLTYEGENLTHLGLNNCLIIERLFSSALMVVISQKDPRVLHVYHFTSRNIICDHRFNKSVLTVRLNRDRIVVCLEDCIYIYNLKDMKMMHNIMDTPTNKLGVLDLTSNPGNALIAYPGSTDTGSVHLFDAINLSSVSTFNAHEGTIACLKFNQEGNMIATASTKGTVIRVYSVPNGHRLFEFRRGVTRCVNIYSLCFSSDSKYLTSSSNTETVHVFKLEKTEGVDNKPEASTEGGG-------------------WFDAINKTFSA---YMPSQVLQVGELMTTERSFATAKLPGAARSNQVSLVSHK---------NQQYVMAATSDGFVYAYRLDPE-GGELDLIKQHNIGPKSDTSRASPTSTGSGGAAKSAEASNQSV---------------PNMD--DPDDFPPM 407
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q6AY57|WIPI2_RAT (WD repeat domain phosphoinositide-interacting protein 2 OS=Rattus norvegicus OX=10116 GN=Wipi2 PE=1 SV=1) HSP 1 Score: 243.047 bits (619), Expect = 2.701e-73 Identity = 142/384 (36.98%), Postives = 203/384 (52.86%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHIT 1193
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + R+ P + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL--EAVREKPPEEPTT----------------------WTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETT 364
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q80W47|WIPI2_MOUSE (WD repeat domain phosphoinositide-interacting protein 2 OS=Mus musculus OX=10090 GN=Wipi2 PE=1 SV=1) HSP 1 Score: 242.662 bits (618), Expect = 3.447e-73 Identity = 142/384 (36.98%), Postives = 203/384 (52.86%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHIT 1193
F FNQD S+ +G+ +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS N+D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ FL SNTETVH+F + R+ P + W Y G L A+TS LP QVTE+F+Q R F+ RLP H+ + ++ R++V DG++Y++ D + GGE L+ + L T
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL--EAVREKPPEEPTT----------------------WTGYFGKVLMASTSYLP---SQVTEMFNQGRAFATVRLPF---------CGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETT 364
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. TrEMBL
Match: A0A2U8LN93 (ATG18 OS=Dugesia japonica OX=6161 GN=Atg18 PE=2 SV=1) HSP 1 Score: 705.286 bits (1819), Expect = 0.000e+0 Identity = 357/448 (79.69%), Postives = 393/448 (87.72%), Query Frame = 3
Query: 30 MQLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERD--NKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDE---TIDSSNLDIADENEFPPIQKL 1358
MQ N VNFIGFNQD+QSILMGN NGY IYGIEMD+V+ KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS SD S+LAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQ SDCLATASDKGTVIRLF+IPSGDKFGEFRRGFARCATISCLSFS++SQFLLVCSNTETVHVFSM Q G++D N+HSI N N+G KD S + +NSYGS W NYVGSALKAT+S LPYPA Q+TEIFSQDRCFSVARLP+ +QS+NH+K + RKVGAVIKYD+GWRI+VATFDGFI+IFKFD ++GGEAEL+ YDL NEK+I KSN + +NKS DS+ +S+ +L K F + + +NLDIADENEFPPIQKL
Sbjct: 1 MQTNNVNFIGFNQDFQSILMGNFNGYMIYGIEMDEVVPKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSTSDFSVLAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQISDCLATASDKGTVIRLFKIPSGDKFGEFRRGFARCATISCLSFSLDSQFLLVCSNTETVHVFSMAQ-GDKDVCNRHSISNFNIGTKDEMICSPINSDNSYGSYWINYVGSALKATSSFLPYPALQMTEIFSQDRCFSVARLPNLDQSTNHLKNSLRKVGAVIKYDNGWRIVVATFDGFIHIFKFDCDLGGEAELLKTYDLINEKYIIKSNPSSIQDNKSKDSLTKQSN-FGLLRPKSFSSDEPSNLQFNNLDIADENEFPPIQKL 446
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. TrEMBL
Match: A0A0R3WCG7 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS8399 PE=4 SV=1) HSP 1 Score: 291.967 bits (746), Expect = 1.041e-88 Identity = 162/427 (37.94%), Postives = 252/427 (59.02%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMV------QNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXW----FNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPS--------TEQSSNHIKIT--------------------HRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPV 1214
F+ FNQD+ ++ +G +GY++ + +V++ S + VGRL+ S+LVV VS D RKL +FH +R+++I + +++N+ILSVK+NR+ +VVC E+ I+I++ +M H++E PSNR+G+ A S D +LAYP ++ G V++F+ NV I AH G +AAL FN PS LATAS++GTV+R+F IP GDK EFRRG ARCA+I L+FS +++FL+ SNTETVHVF + + + ++ P S+ + D + ++D+ + S+W N+VG ALKA + LP P V E+FSQDR F+ A +PS T + +H+ T +K A++ Y +R++VA DG+++IF FD GGEA L+ ++N +++ N P
Sbjct: 17 FVDFNQDFTTLCIGTRSGYSLLSTDNHEVLETYSVNGESMCLVGRLFTSNLVVLVSLRDMRKLLIFHSRRDSLICDYRYTNTILSVKMNRQRLVVCLENEIFIHNIRDMSVLHRIEDTPSNRNGVIAFSTCPDKCLLAYPGSSRVGTVYIFDALTFTNVTSIAAHDGVLAALAFNAPSTLLATASERGTVVRVFSIPDGDKLMEFRRGLARCASICSLNFSTDNRFLVCASNTETVHVFKLYGPASPSSSSKGEDGACTPGSSQLSSD-TNLNSSTDDTASTSSWTGSLVNWVGGALKAGVAYLPNP---VAEVFSQDRSFAFAWIPSAATNLASATSATVSHVAATTTVSPHGDGEHGGSGQAGTAFKKTAALLCYGDQYRLLVAGLDGYLHIFTFDSVRGGEATLLRTQSIANVIYVSLINSGPA 439
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. TrEMBL
Match: A0A0R3T8K7 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS3394 PE=4 SV=1) HSP 1 Score: 285.034 bits (728), Expect = 6.132e-87 Identity = 163/437 (37.30%), Postives = 257/437 (58.81%), Query Frame = 3
Query: 45 VNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSN-SDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXW----FNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPS-----TEQSSN---HIKITH---------RKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELI---VIYDLSNEKHITKSNQPPVLENKSL-DSMNSRSDSLNVLSS 1277
+ +I FNQDY S+ +G +GY++ E D+V + + P+ VGRL+ S+LV VS DPR+L +FH +R+++I + ++S++IL+VK+NR+ ++VC ED I+I++ +M+ H++E P N++G+ A S+ S+ +LAYP TG V++F+ + NV I AH G +A L FN S LATAS++GTV+R+F IP G++ EFRRG AR T+ L+FS + +FL+ SNTETVH+F + + G +P + + +S ++ ++ ++W N+VG ALK S LP P V E+F+QDR F+ AR+P ++ S+N H H +K A+I +R++VA+ DG+IY F FD GGEA LI I + +T ++QP +S D+ + SD+ SS
Sbjct: 15 IYYIDFNQDYTSLCIGTRSGYSLLSTENDQVTETYTINGEPMYLVGRLFTSNLVTLVSAVDPRRLLIFHSRRDSLICDYRYSSTILAVKMNRQRLIVCVEDEIFIHNIRDMELLHRIENTPLNKYGVIAFSSRSEKCLLAYPGVYKTGTVYIFDAIKFSNVTSIAAHDGPLAVLAFNTSSTLLATASERGTVVRVFTIPEGERVMEFRRGIARYVTVCSLNFSADDRFLVCASNTETVHIFKLHKPGSA--SPGLPEEGSTSSGLDTASQLTEESASSASWTGTVMNWVGGALKTGASYLPNP---VAEVFTQDRSFAFARIPPGSRTVSQASANIPQHGDGDHLSEGPGSGCKKTAAIICNGDRYRLLVASLDGYIYTFNFDPIHGGEATLISAQTIISPNGNGIVTPTHQPNQRAPRSCTDTASPDSDTHTTQSS 446
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. TrEMBL
Match: A0A068YK20 (WD40 repeat domain containing protein OS=Echinococcus multilocularis OX=6211 GN=EmuJ_001139000 PE=4 SV=1) HSP 1 Score: 278.1 bits (710), Expect = 8.596e-84 Identity = 154/410 (37.56%), Postives = 241/410 (58.78%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNG-------ERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXW----FNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPS-------------------TEQSSNHIKITH----------RKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELI 1157
F FNQD+ ++ +G +GY++ + +V++ P+ VGRL+ S+LVV VS D RKL +FH +R+++I + +++N+ILSV++NR+ +VVC E+ I+I++ +M H++E PSNR+G+ A S D +LAYP ++ G V++F+ + N+ I AH G +AAL FN S LATAS++GTV+R+F IP+GDK EFRRG AR A+I L+FS +++FL+ SNTETVHVF + + ++ P S+ DA +S ++D+ + +W ++VG ALKA + LP P V E+FSQDR F+ A +PS +S H + H +K A++ + +R++VA DG+++IF FD GGEA L+
Sbjct: 17 FADFNQDFTTLCIGTRHGYSLLSTDNHEVLETYGVNGEPMCLVGRLFTSNLVVLVSLHDMRKLLIFHSRRDSLICDYRYTNTILSVRMNRQRLVVCLENEIFIHNIRDMTVLHRIEDTPSNRNGVVAFSTCPDKCLLAYPGSSRVGTVYIFDASTFTNITSIAAHDGLLAALAFNVSSTLLATASERGTVVRVFSIPAGDKLMEFRRGLARYASICSLNFSTDNRFLVCASNTETVHVFKLYGPASPPSSFCKAEDSACTPGSSTHGSDA-NASSSTDDAASTGSWTGSLVSWVGGALKAGAAYLPNP---VAEVFSQDRSFAFAWIPSAAAANLASVNSPASVSHVTAASASPHGDVEHGGSGQVGTAFKKAAALLCHGDQYRLLVAGLDGYLHIFTFDSARGGEATLL 422
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. TrEMBL
Match: A0A0X3PTK6 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=TR118910 PE=4 SV=1) HSP 1 Score: 278.87 bits (712), Expect = 5.946e-83 Identity = 165/453 (36.42%), Postives = 241/453 (53.20%), Query Frame = 3
Query: 45 VNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDN----------------KHSIPNSNLGNK-------------------DAXXXXXXXXXXXXXXXW----FNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSN------------HIKITH-------------RKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQP 1208
V F+ FNQD+ S+ +G +GY++ D+V + S + P+ VGRL+ SSLV VS ++ RKL +FH++R +I E ++S++I++VK+NR+ +VVC ED I+I++ +M+ HKVE P NR G+ ALS N LAYP ++ G V +F+ NV I AH G +AAL FN + LATAS++GTV+R+F IP GD+ EFRRG ARCA I CLSFS+++ FL+ SNTETVHVF + R + ++ + S+ GN S + + W +VGSALKAT + LP+ QV+E+FSQDR F+ A +PS+ + TH +KV A+ + +R++VA DG ++I+ D GGEA LI +L S+ P
Sbjct: 38 VIFVDFNQDFTSLCVGTRSGYSLLSTVGDQVTEIFSLNVDPMCMVGRLFTSSLVTLVSLNNMRKLLVFHYRRKTLICEYQYSHTIVAVKMNRQRLVVCVEDDIFIHNIRDMEMLHKVEETPPNRSGVIALSSNPAKCYLAYPGSHRVGTVFIFDALNFTNVTSIAAHDGLLAALTFNSAATMLATASERGTVVRVFSIPQGDRLMEFRRGLARCAQICCLSFSLDNHFLVAASNTETVHVFKLDSTAPRPDGTVGGDGALAGRRFPTEYDLDGSSTGNTRYYDGDQGTGLGGGTAVGCQQANQSGTAGGANSAVGWSGGLVQWVGSALKATAAYLPH---QVSEVFSQDRSFAYAHIPSSCAAPGCYASGASGAGAGGFPDTHYVSGDAATSVFGVKKVAAITYVNHQYRLLVAGLDGLLHIYSIDPVQGGEATLIRTQNLLAPTPAIPSSVP 487
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Cavefish
Match: wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:NCBI gene;Acc:103028226]) HSP 1 Score: 247.284 bits (630), Expect = 4.025e-76 Identity = 152/443 (34.31%), Postives = 225/443 (50.79%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHI-------TKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
F FNQD S+ +G +GY + + +DK+ Q E + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS ++D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM+ +L SNTETVH+F + +R+ P + W Y G L A+T+ LP QV+E+F+Q R F+ RLP + H+ + A+ R++VA DG++Y++ D + GGE L+ + L T +P V + S S+ + D D + L + +ENE PP+
Sbjct: 17 FANFNQDNTSLAVGTKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSISNDNCYLAYPGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGLYLSASSNTETVHIFKL--ETQREKPQEEPTT----------------------WTGYFGKVLMASTTYLP---AQVSEMFTQGRAFATVRLPFS---------GHKNICALAIIQKIPRLLVAAADGYLYLYNLDPQEGGECTLMKQHKLDGSAEPANEILDQTAHERPLVAQTYSAAVAKGYSEDQGAVGGAGVED---DMNALHLDEENEQPPL 420
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Cavefish
Match: wipi1 (WD repeat domain, phosphoinositide interacting 1 [Source:NCBI gene;Acc:103046600]) HSP 1 Score: 208.379 bits (529), Expect = 3.826e-61 Identity = 146/450 (32.44%), Postives = 228/450 (50.67%), Query Frame = 3
Query: 60 FNQDYQSILMGNSNGYTIYGIEMDKVIQ--KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDL--SNE--KHITKSNQPPVLENKSLDS-----------MNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPIQK 1355
FNQD S+ +G GY ++ + ++ ES + + V RL++SSLVV VS PR++ ++H K+ I +SN+IL+V+LNR+ +VVC E+ IYI++ ++MK + P N G+ ALS N +S LAYP + G + V++ + V +I AH +AA+ FN LA+AS++GTVIR+F IP G + EFRRG R IS LSFS ++QFL SNTETVH+F + Q+G + + W YVG A +S LP QV+ + SQDR F+ RL + Q + T +K+ R++VA+ D ++I+ D + GGE L+ ++ L S+E + S P ++ + + + S+ V + + + + + DE EFPPI +
Sbjct: 20 FNQDSTSLAVGTKTGYRLFSVTAVDRLECIHESAESPDVYIVERLFSSSLVVVVSQAMPRRMNVYHFKKGTEICNYSYSNTILAVRLNRQRLVVCLEESIYIHNIKDMKLLKTLLNTPPNPSGLCALSINHSNSYLAYPGSATIGEIIVYDANNLNTVTMIPAHDSPLAAITFNASGTKLASASERGTVIRVFSIPEGLRLFEFRRGMKRYVNISSLSFSPDAQFLCASSNTETVHIFKLEQHGPSGEEET------------------------PTWSAYVGKMFTAASSYLP---SQVSGMMSQDRAFATVRLHTAGQKNVCTLATIQKL---------PRLLVASSDEQLFIYNIDPQDGGECTLVQMHRLLVSDEEREEAAVSEGPGAPQSYAATAAIPTSAPVSATLTGYSEDGGVSRGEVIPEHEFAAGPVCLDDETEFPPINR 433
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Cavefish
Match: wdr45b (WD repeat domain 45B [Source:NCBI gene;Acc:103038085]) HSP 1 Score: 117.087 bits (292), Expect = 1.600e-28 Identity = 80/271 (29.52%), Postives = 147/271 (54.24%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIP--IMKVGRLYNSSLVVFVSTDD-----PRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYD-TENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEM-KNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNL 821
N + + GFNQD+ G NG+ +Y D + +KE + + + V L+ + + V P K+ ++ + +IE++FS + +VKL R +VV + I ++ T N + H E N G+ L NS++S+LA+P T+ +G+V + ++A + V I AH+GA+ + N +ATAS+KGT+IR+F +G E RRG ++ A I C++F+ ++ + V S+ TVH+F+ ++ +R+ + S+ +++
Sbjct: 11 NGLLYAGFNQDHGCFACGMENGFRVY--NTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETC-YNPKGLCVLCPNSNNSLLAFPGTH-SGHVQIVDLANTERPPVDIPAHEGALCCIALNLQGTRIATASEKGTLIRIFDTSAGHLIQELRRG-SQTANIYCINFNQDASLICVSSDHGTVHIFA-AEDPKRNKQSSLASASF 275
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Cavefish
Match: ENSAMXT00000029948.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001250.1:4945:9934:-1 gene:ENSAMXG00000041775.1 transcript:ENSAMXT00000029948.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 102.449 bits (254), Expect = 1.291e-23 Identity = 73/252 (28.97%), Postives = 125/252 (49.60%), Query Frame = 3
Query: 33 QLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMK-----NVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSM 770
Q VN + FNQD +G IY +E P+M+ G L ++++ DD R++ ++ +++E F+ +L+V++ +++ ++ IY+Y + K N G+ +S S + +L +P + G++ + +++ K I AHQ IA L NQP +A+AS KGT+IRLF + DK E RRG AT+ C++FS +S FL S+ TVH+F++
Sbjct: 3 QQRGVNSLHFNQDQSCFCCAMESGVRIYNVE-------------PLMEKGHL----VLIW---DDAREV---RDTKDKLVLEFTFTKPVLAVRMRHDKIIIVLKNRIYVYSFPDNPVKLFEFDTRDNAKGLCDVSPSMEKQLLVFPG-HKCGSLQLVDLSNTKPGTSSAPFTINAHQSEIACLALNQPGSVVASASRKGTLIRLFDTTTRDKLVELRRG-TDPATLYCINFSHDSSFLCASSDKGTVHIFAL 229
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Cavefish
Match: wdr45 (WD repeat domain phosphoinositide-interacting protein 4 [Source:NCBI gene;Acc:103032640]) HSP 1 Score: 102.449 bits (254), Expect = 1.337e-23 Identity = 73/252 (28.97%), Postives = 125/252 (49.60%), Query Frame = 3
Query: 33 QLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMK-----NVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSM 770
Q VN + FNQD +G IY +E P+M+ G L ++++ DD R++ ++ +++E F+ +L+V++ +++ ++ IY+Y + K N G+ +S S + +L +P + G++ + +++ K I AHQ IA L NQP +A+AS KGT+IRLF + DK E RRG AT+ C++FS +S FL S+ TVH+F++
Sbjct: 3 QQRGVNSLHFNQDQSCFCCAMESGVRIYNVE-------------PLMEKGHL----VLIW---DDAREV---RDTKDKLVLEFTFTKPVLAVRMRHDKIIIVLKNRIYVYSFPDNPVKLFEFDTRDNAKGLCDVSPSMEKQLLVFPG-HKCGSLQLVDLSNTKPGTSSAPFTINAHQSEIACLALNQPGSVVASASRKGTLIRLFDTTTRDKLVELRRG-TDPATLYCINFSHDSSFLCASSDKGTVHIFAL 229
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003716.1 (pep scaffold:Pmarinus_7.0:GL479713:1785:12472:1 gene:ENSPMAG00000003370.1 transcript:ENSPMAT00000003716.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 98.5969 bits (244), Expect = 9.378e-23 Identity = 78/271 (28.78%), Postives = 133/271 (49.08%), Query Frame = 3
Query: 30 MQLNAVNFIGFN-QDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGR---LYNSSLVVFVST--------------DDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMK-----NVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSM 770
Q+ +N + FN Q+ +G IY +E +++K + + VGR L+ S+L+ V DD R+ R+ ++++ F++++L+V++ ++V IY++ + +K N G+ L S + +L +P + G++ + +++ K I AHQG IA + NQP +A+AS KGT+IRLF S K E RRG A AT+ C++FS +S FL V S+ TVHVF++
Sbjct: 2 FQVAPINILTFNKQNPGCFCCAMESGLRIYNVE--PLMEKAHLDVDQVGSVGRVEMLHRSNLLALVGGGSSPKFADNSVLVWDDARE---GRDARDKLVLDFTFTSAVLAVRMRHDKIIVVLRYRIYVFTFPDNPQKIFEFDTRDNPDGLCELCPSLEKPLLVFPG-HKCGSLQLVDLSNTKPGTSSAPFTINAHQGEIACIALNQPGSLVASASKKGTLIRLFDTQSKVKLVELRRG-ADPATLYCINFSHDSSFLCVSSDKGTVHVFAL 265
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003150.1 (pep scaffold:Pmarinus_7.0:GL476673:220998:228897:1 gene:ENSPMAG00000002877.1 transcript:ENSPMAT00000003150.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 70.8626 bits (172), Expect = 4.290e-14 Identity = 50/173 (28.90%), Postives = 88/173 (50.87%), Query Frame = 3
Query: 300 LSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNV------------VIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQN 779
+SV L RK I+++ + R+ N G+ LS S + S+L +P +G + + +I+ +K V ++AH+ +A + + + +ATAS KGT+IR++ +GD+ E RRG A A + C++FS ++ FL S+ TVH+F++ Q
Sbjct: 2 ISVVLRRK---------IHVFSFPDNPRETSQFDTRDNPLGLCELSTSLERSLLVFPGLK-SGFLQMVDISALKGAPKRPGLGPNESGVTVKAHESGLACIALDSTASRVATASHKGTLIRIYDTTNGDRTMELRRG-ADSAQLYCINFSQDASFLCASSDKGTVHIFALKQT 163
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Yeast
Match: ATG18 (Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood [Source:SGD;Acc:S000001917]) HSP 1 Score: 98.5969 bits (244), Expect = 1.983e-22 Identity = 79/285 (27.72%), Postives = 135/285 (47.37%), Query Frame = 3
Query: 483 GNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFN---------------YVGSALKATTSLLPYPAQ----------------QVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGW------------------------RIIVATFDGFIYIFKFDYEVGGEAELIVIYDL 1172
G+V VFN+ ++ ++IEAH+G IAA+ + +ATASDKGT+IR+F I +GDK +FRRG I +SFS +SQ+L V +++TVH+F + HS+ N+ L + D+N +D++S + + YV ++ K ++ Y +Q +VT + R F+ +LP ++++H+ +T +G+ I D+ I V + DG++Y F D E GG+ ++ Y +
Sbjct: 225 GDVIVFNLETLQPTMVIEAHKGEIAAMAISFDGTLMATASDKGTIIRVFDIETGDKIYQFRRG-TYATRIYSISFSEDSQYLAVTGSSKTVHIFKL--------GHSMSNNKLDSDDSNMEEAAADDSSLDTTSIDALSDEENPTRLAREPYVDASRKTMGRMIRYSSQKLSRRAARTLGQIFPIKVTSLLESSRHFASLKLPV--ETNSHV-MTISSIGSPIDIDTSEYPELFETGNSASTESYHEPVMKMVPIRVVSSDGYLYNFVMDPERGGDCLILSQYSI 497 HSP 2 Score: 88.5817 bits (218), Expect = 3.756e-19 Identity = 58/168 (34.52%), Postives = 90/168 (53.57%), Query Frame = 3
Query: 45 VNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDD-----PRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMKNVVI 530
+NFI FNQ I +G S G+ I+ E E + I+++ L+++SL+ V D PR+L + + K++++I EV F SILSVK+N+ +VV ++ IYIYD M+ H +E P N G+ A+S S +S L YPS N + A N+ +
Sbjct: 8 INFINFNQTGTCISLGTSKGFKIFNCEPFGKFYSEDSGGYAIVEM--LFSTSLLALVGIGDQPALSPRRLRIINTKKHSIICEVTFPTSILSVKMNKSRLVVLLQEQIYIYDINTMRLLHTIETNP-NPRGLMAMSPSVANSYLVYPSPPKVINSEIKAHATTNNITL 172
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Yeast
Match: HSV2 (Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization [Source:SGD;Acc:S000003455]) HSP 1 Score: 81.2629 bits (199), Expect = 5.382e-17 Identity = 75/278 (26.98%), Postives = 125/278 (44.96%), Query Frame = 3
Query: 54 IGFNQDYQSILMGNSNGYTIYGIE-----MDKVIQKESNKIIPIMKVG---RLYNSSLVVFVSTDD-PR----KLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTE-NMKRKHKVEIAPSNRHGIFALSNSDH-------------SILAYPSTNMTGNVHVFNIAEMK------------NVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSM 770
+ FNQD + NG+ I+ + + K ++ + +G LY ++ + V PR KL ++ I +KF +SI V L+R +VV E+ I I+ + N +R + P N + + +S H I+A+PS G + V +++++K II+AH+ I + N+ +AT S +GT+IR+F +G EFRRG + A I +SFS N L V SN +T+H+F +
Sbjct: 22 VSFNQDDSCFSVALENGFRIFNTDPLTSKLSKTFKESATNQSRGTGIGYTRMLYRTNYIALVGGGKRPRHALNKLIIWDDLLQKETITLKFMSSIKDVFLSRIHIVVVLENTIEIFQFQTNPQRICPILDIPPNGSVDYVVCSSKHLQSQASQSQSKILEIIAFPSNKCVGQIQVADLSQIKYNSQNPKESALLPTSIIKAHKNPIKLVRLNRQGTMVATCSVQGTLIRIFSTHNGTLIKEFRRGVDK-ADIYEMSFSPNGSKLAVLSNKQTLHIFQI 298
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Yeast
Match: ATG21 (Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [Source:SGD;Acc:S000006021]) HSP 1 Score: 59.3066 bits (142), Expect = 6.655e-10 Identity = 46/152 (30.26%), Postives = 71/152 (46.71%), Query Frame = 3
Query: 426 FALSNSDHSILAY-----PSTNMTGNVHVFNIA--EMKNVVII----EAHQGAIAALEFNQPSDCLATASDKGTVIRLFR-------IPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGN 827
LSN D SIL + P N + ++++ + NV + H+G +A L + LATASDKGT+IR+F + S F EFRRG R + L+F + + +T+T+H+F + D +S+P N N
Sbjct: 246 MVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRG-TRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKL-----DDASNSLPGDNSSN 391
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Nematostella
Match: EDO38563 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCQ4]) HSP 1 Score: 236.498 bits (602), Expect = 2.761e-73 Identity = 138/372 (37.10%), Postives = 197/372 (52.96%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIEMDKVIQK--ESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELI 1157
F+ FNQD S+ +G +GY +Y + + +++ E I V RL++SSLV VS PRKL + H K+ I + N+IL+V+LNR ++V E+ +YI++ +MK H + P N G+ ALS NSD+ LAYP +N G V +F+ ++ V +I AH +A++ FN LATAS+KGTVIR+F IP G K EFRRG RC TI+ L+FS +S FL SNTETVH+F + ++ + S W Y G AL T Y QVTE+F+Q R F+ LP R V AV R++V++ DG++YI+ D E GG+ L+
Sbjct: 16 FVNFNQDCTSLAIGTKSGYKLYSLGSVEKLEEIYEYGGTPDICIVERLFSSSLVAIVSLSAPRKLKVCHFKKGTEICNYSYPNTILAVRLNRVRLLVVLEESLYIHNIRDMKVLHTIRDTPPNPSGLCALSVNSDNCYLAYPGSNQIGEVQIFDAVNLRAVTMIPAHDSPVASMAFNHMGTKLATASEKGTVIRVFSIPDGQKLYEFRRGVKRCVTINSLAFSQDSLFLSASSNTETVHIFKLEMPKDKPQEES------------------------QGWMGYFGKALSPTN----YLPSQVTEVFNQGRAFANVHLPVAGL---------RNVCAVATIGKLPRLLVSSADGYLYIYNIDPEDGGDCTLL 350
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Nematostella
Match: EDO34738 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNI2]) HSP 1 Score: 111.309 bits (277), Expect = 5.531e-27 Identity = 81/267 (30.34%), Postives = 145/267 (54.31%), Query Frame = 3
Query: 39 NAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTD-DPR----KLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYD-TENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVI-IEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNS 815
N + F GFNQD G +G+ IY + K +++ I V L+ + + V P+ ++ ++ + +IE+ FS+ + +VKL R +VV ++ I ++ T+N ++ H E A +N G+ L +S++S+LA+P+ TG+V + ++A + + I AH+ ++ L N LATAS+KGT+IR+F +G + E RRG A I C++F+ +S+ L V S+ TVH+F++ ++ NK + +S
Sbjct: 11 NGLLFAGFNQDQGCFACGMESGFRIYNCDPLKEKERQDFTDGGIGHVEMLFRCNYLALVGGGRSPKYPANRVMVWDDLKKKCVIELDFSSDVRAVKLRRDRIVVVLDNLIKVFTFTQNPQQLHVFETA-NNPKGLCVLCPSSNNSLLAFPARK-TGHVQIVDLANTERAPLEIAAHEAPMSCLAMNLQGTRLATASEKGTLIRVFDTSNGAQLHELRRGSGS-AHIYCINFNQDSELLCVSSDHGTVHIFAI--EDQKKNKQTSSSS 272
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Nematostella
Match: EDO43705 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXY8]) HSP 1 Score: 95.5153 bits (236), Expect = 1.279e-21 Identity = 76/260 (29.23%), Postives = 130/260 (50.00%), Query Frame = 3
Query: 39 NAVNFIGFNQD---YQSILMGNSNGYTIYGIE--MDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLT-----LFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNS-DHSILAYPSTNMTGNVHVFNIAEMK-----NVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSM 770
N V + FNQD + S L +S G IY E +K +N++ + +V L+ ++L+ V T + + ++ R +++E+ + + + +V++ R + V + I++Y N K + N G+ + S + IL +P G+V + ++ + + I AHQG +AAL NQ +ATAS KGT+IR+F E RRG A AT+ C++FS +S FL V S+ TVH+F++
Sbjct: 3 NGVLHLAFNQDQGCFASAL--DSKGIRIYNTEPLSEKARLAMTNELYQVSQVHMLHRTNLIAIVGTGPGARFSNDKVYVWDDSRKELVLEMTYGSPVTTVRMQRDKLFVALRNKIHVYSFPNNVLKLFDFDSRDNPKGLCEVCPSLERPILVFPGRK-CGSVQLVDLLNRQPDTSSAPLTINAHQGELAALAINQQGTQVATASQKGTLIRVFDTQGRTLVVELRRG-ADPATLYCINFSHDSAFLCVSSDKGTVHIFAL 258
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Medaka
Match: wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:NCBI gene;Acc:101171834]) HSP 1 Score: 254.218 bits (648), Expect = 9.148e-79 Identity = 158/448 (35.27%), Postives = 235/448 (52.46%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPP--VLENKSLD-SMNSRSDSLNVLSSKKFLDETI---------DSSNLDIADENEFPPI 1349
F FNQD S+ +G+ +GY + + +DK+ Q E N + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS ++D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM +L SNTETVH+F + E+ P + W Y+G L A+T+ LP QVTE+F+Q R F+ RLP H+ + A+ R++VA DG++Y++ D + GGE L+ + + S +PP +LE D + +++ S V +K + +E D S+L + +ENE PP+
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECNDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSISNDNCYLAYPGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMEGLYLSASSNTETVHIFKLETQKEKYVPAEEPTT----------------------WGGYLGKVLMASTTYLP---AQVTEMFTQGRAFATVRLPF---------CGHKNICALAVIQKIPRLLVAAADGYLYLYNLDPQEGGECTLM------KQHRLDSSAEPPNEILEQGPHDRPLTTQTYSAAV--TKGYCEEQGAMGGAGLEDDLSDLRLEEENEQPPL 422
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Medaka
Match: wipi2 (WD repeat domain, phosphoinositide interacting 2 [Source:NCBI gene;Acc:101171834]) HSP 1 Score: 246.514 bits (628), Expect = 2.689e-76 Identity = 146/400 (36.50%), Postives = 212/400 (53.00%), Query Frame = 3
Query: 51 FIGFNQDYQSILMGNSNGYTIYGIE-MDKVIQ-KESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPP--VLENKSLD 1235
F FNQD S+ +G+ +GY + + +DK+ Q E N + V RL++SSLV VS PRKL + H K+ I +SN+IL+VKLNR+ ++VC E+ +YI++ +MK H + P N G+ ALS ++D+ LAYP + G V VF+ ++ +I AH +AAL F+ LATAS+KGTVIR+F IP G K EFRRG RC +I L+FSM +L SNTETVH+F + E+ P + W Y+G L A+T+ LP QVTE+F+Q R F+ RLP H+ + A+ R++VA DG++Y++ D + GGE L+ + + S +PP +LE D
Sbjct: 17 FANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECNDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCALSISNDNCYLAYPGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMEGLYLSASSNTETVHIFKLETQKEKYVPAEEPTT----------------------WGGYLGKVLMASTTYLP---AQVTEMFTQGRAFATVRLPF---------CGHKNICALAVIQKIPRLLVAAADGYLYLYNLDPQEGGECTLM------KQHRLDSSAEPPNEILEQGPHD 376
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Medaka
Match: wipi1 (WD repeat domain phosphoinositide-interacting protein 1 [Source:NCBI gene;Acc:101159269]) HSP 1 Score: 215.312 bits (547), Expect = 1.151e-63 Identity = 155/458 (33.84%), Postives = 229/458 (50.00%), Query Frame = 3
Query: 60 FNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARL-PSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQ----------PP----------------VLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPI 1349
FNQD S+ +G GY I+ + V Q ES ++ + RL++SSLVV VS P+++T++H K+ I +S++IL+VKLNR+ +VVC E+ IYI++ ++MK + P N G+ ALS N+ +S LAYP + TG + V+ + V +I AH +AAL FN ++ LA+AS++GTVIR+F IP G + EFRRG R +I LSFS ++ FL SNTETVHVF + Q + + W +YVG L A +S LP QV + SQDR F+ L PS H V +++ +++V T DG + +F D + GGE EL+ + L ++ T ++ PP L S DS R + V+ +F S + + DENEFPP+
Sbjct: 25 FNQDSTSLALGTRTGYKIF--SLSSVEQLES-EVPDVFIAERLFSSSLVVVVSRAVPQRMTIYHFKKGTEICSYSYSSNILAVKLNRQWLVVCLEESIYIHNIKDMKLIQTLLNVPPNPSGLCALSINNSNSFLAYPGSATTGEIVVYGANTLSTVTVISAHDAPLAALTFNTSANKLASASERGTVIRVFSIPEGLRLFEFRRGLKRYVSIRSLSFSPDALFLCASSNTETVHVFRLEQLEPTEGAEP------------------------ATWTSYVGRMLSAASSYLP---AQVCDAMSQDRAFATVHLTPS----------AHSSVCSLVSIQKLLQLLVVTADGQLCVFNVDLQDGGECELLFKHSLFDDHGSTAKSRESADSEQTVCPPSYAATAALPASRPVTATLTGYSEDSGAKRGE---VIPEHEFA-----SGPVRLDDENEFPPV 434
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Medaka
Match: WIPI1 (WD repeat domain, phosphoinositide interacting 1 [Source:NCBI gene;Acc:101171782]) HSP 1 Score: 213.386 bits (542), Expect = 4.098e-63 Identity = 135/369 (36.59%), Postives = 199/369 (53.93%), Query Frame = 3
Query: 60 FNQDYQSILMGNSNGYTIYGI-EMDKV-IQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELI 1157
FNQD S+ +G GY ++ + +DK+ E + I V RL++SSLVV VS PR++ ++H K+ I +SN+ILSV+LNR+ +VVC E+ IYI++ +MK + P N G+ ALS N +S LAYP + G + +++ + V +I+AH +AAL FN LA+AS+KGTVIR+F IP G K EFRRG R +IS LSFS ++QFL SNTETVH+F + Q+ ++ S W YVG A ++ LP V+++ QDR F+ RL N + + + A+ R++ A+ DGF+YI+ D + GGE L+
Sbjct: 21 FNQDTTSLSVGTKTGYRLFSVTAVDKLECIHEGAECPDIYIVERLFSSSLVVVVSLSMPRRMNVYHFKKGTEICNYSYSNNILSVRLNRQRLVVCLEESIYIHNIRDMKLLKTLLNTPVNPSGLCALSVNQSNSYLAYPGSATMGEITIYDANNLSTVTLIQAHDSPLAALTFNASGSKLASASEKGTVIRVFSIPEGQKLFEFRRGMKRYVSISSLSFSADAQFLCASSNTETVHIFKLEQHSPSQDEES------------------------PTWSAYVGKMFTAASTYLP---THVSDMMHQDRAFATVRL-------NMFGL--KNICALATIQKLPRLLAASSDGFLYIYNVDPQDGGECVLV 353
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Medaka
Match: wipi1 (WD repeat domain phosphoinositide-interacting protein 1 [Source:NCBI gene;Acc:101159269]) HSP 1 Score: 207.608 bits (527), Expect = 8.188e-61 Identity = 152/457 (33.26%), Postives = 230/457 (50.33%), Query Frame = 3
Query: 78 SILMGNSNGYTIYGI----EMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARL-PSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQ----------PP----------------VLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPIQ 1352
S+ +G GY I+ + +++ + Q N++ + RL++SSLVV VS P+++T++H K+ I +S++IL+VKLNR+ +VVC E+ IYI++ ++MK + P N G+ ALS N+ +S LAYP + TG + V+ + V +I AH +AAL FN ++ LA+AS++GTVIR+F IP G + EFRRG R +I LSFS ++ FL SNTETVHVF + Q + G + A W +YVG L A +S LP QV + SQDR F+ L PS H V +++ +++V T DG + +F D + GGE EL+ + L ++ T ++ PP L S DS R + V+ +F S + + DENEFPPI+
Sbjct: 22 SLALGTRTGYKIFSLSSVEQLECIYQ---NEVPDVFIAERLFSSSLVVVVSRAVPQRMTIYHFKKGTEICSYSYSSNILAVKLNRQWLVVCLEESIYIHNIKDMKLIQTLLNVPPNPSGLCALSINNSNSFLAYPGSATTGEIVVYGANTLSTVTVISAHDAPLAALTFNTSANKLASASERGTVIRVFSIPEGLRLFEFRRGLKRYVSIRSLSFSPDALFLCASSNTETVHVFRLEQLEPTE----------GAEPA--------------TWTSYVGRMLSAASSYLP---AQVCDAMSQDRAFATVHLTPS----------AHSSVCSLVSIQKLLQLLVVTADGQLCVFNVDLQDGGECELLFKHSLFDDHGSTAKSRESADSEQTVCPPSYAATAALPASRPVTATLTGYSEDSGAKRGE---VIPEHEF-----ASGPVRLDDENEFPPIK 430
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Planmine SMEST
Match: SMESG000032825.1 (SMESG000032825.1) HSP 1 Score: 880.937 bits (2275), Expect = 0.000e+0 Identity = 441/443 (99.55%), Postives = 442/443 (99.77%), Query Frame = 3
Query: 30 MQLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDAXXXXXXXXXXXXXXXWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIIVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPIQKL 1358
MQLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDANYSSINSDNNSY SNWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRI+VATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPIQKL
Sbjct: 1 MQLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVGRLYNSSLVVFVSTDDPRKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALSNSDHSILAYPSTNMTGNVHVFNIAEMKNVVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNSNLGNKDANYSSINSDNNSYSSNWFNYVGSALKATTSLLPYPAQQVTEIFSQDRCFSVARLPSTEQSSNHIKITHRKVGAVIKYDSGWRIVVATFDGFIYIFKFDYEVGGEAELIVIYDLSNEKHITKSNQPPVLENKSLDSMNSRSDSLNVLSSKKFLDETIDSSNLDIADENEFPPIQKL 443
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Planmine SMEST
Match: SMESG000020794.1 (SMESG000020794.1) HSP 1 Score: 97.0561 bits (240), Expect = 1.014e-21 Identity = 80/276 (28.99%), Postives = 139/276 (50.36%), Query Frame = 3
Query: 42 AVNFIGFNQDYQSILMGNSNGYTIYGIE-------MDKVIQKESNKIIPIMKVGRLYNSS-LVVFVSTDDP----RKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKN-----VVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNS 815
+NFIGFNQD +G NG+ ++ + MD + Q +S + V L+ ++ L + +P K ++ + +IE ++++ I +VKL +V+ E I +Y E + + +N G+ A+S +S + ++A+P + G V + ++ +N ++ AHQ ++A+ FN +ATAS KGT+IR+F G K E RRG A I +SF+ +S + V S+ +TVHVF + N +K+S+ NS
Sbjct: 15 GINFIGFNQDAGCFAVGLKNGFRVFNSDPLKENERMDFLNQTQSG----VGHVEMLFRTNFLGILGGGSNPMFPANKCCVWDDIKRKFVIEFEYASDIKAVKLRFDRMVIVLELSIKVYSFEALPKLLFNCDTGANPMGMCAVSHSSSNPLMAFPDRKL-GKVVIVDLTRYENETTNPIISFGAHQNQLSAIVFNSIGTLIATASIKGTLIRVFNPRKGIKLFELRRG-TNPAAIYSISFNQDSTMMSVTSDHDTVHVFKITPNALGFDKNSLSNS 284
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Planmine SMEST
Match: SMESG000020794.1 (SMESG000020794.1) HSP 1 Score: 97.0561 bits (240), Expect = 1.126e-21 Identity = 79/276 (28.62%), Postives = 139/276 (50.36%), Query Frame = 3
Query: 42 AVNFIGFNQDYQSILMGNSNGYTIYGIE-------MDKVIQKESNKIIPIMKVGRLYNSSLV-VFVSTDDP----RKLTLFHHKRNAVIIEVKFSNSILSVKLNRKVVVVCTEDGIYIYDTENMKRKHKVEIAPSNRHGIFALS-NSDHSILAYPSTNMTGNVHVFNIAEMKN-----VVIIEAHQGAIAALEFNQPSDCLATASDKGTVIRLFRIPSGDKFGEFRRGFARCATISCLSFSMNSQFLLVCSNTETVHVFSMVQNGERDNKHSIPNS 815
+NFIGFNQD +G NG+ ++ + MD + Q +S + V L+ ++ + + +P K ++ + +IE ++++ I +VKL +V+ E I +Y E + + +N G+ A+S +S + ++A+P + G V + ++ +N ++ AHQ ++A+ FN +ATAS KGT+IR+F G K E RRG A I +SF+ +S + V S+ +TVHVF + N +K+S+ NS
Sbjct: 15 GINFIGFNQDAGCFAVGLKNGFRVFNSDPLKENERMDFLNQTQSG----VGHVEMLFRTNFLGILGGGSNPMFPANKCCVWDDIKRKFVIEFEYASDIKAVKLRFDRMVIVLELSIKVYSFEALPKLLFNCDTGANPMGMCAVSHSSSNPLMAFPDRKL-GKVVIVDLTRYENETTNPIISFGAHQNQLSAIVFNSIGTLIATASIKGTLIRVFNPRKGIKLFELRRG-TNPAAIYSISFNQDSTMMSVTSDHDTVHVFKITPNALGFDKNSLSNS 284 The following BLAST results are available for this feature:
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 3
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of WD repeat domain phosphoinositide-interacting protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30035095 ID=SMED30035095|Name=WD repeat domain phosphoinositide-interacting protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1588bpback to top protein sequence of SMED30035095-orf-1 >SMED30035095-orf-1 ID=SMED30035095-orf-1|Name=SMED30035095-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=444bp MQLNAVNFIGFNQDYQSILMGNSNGYTIYGIEMDKVIQKESNKIIPIMKVback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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