Hepatocyte growth factor-regulated tyrosine kinase substrate

Overview
NameHepatocyte growth factor-regulated tyrosine kinase substrate
Smed IDSMED30034997
Length (bp)2809
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Hepatocyte growth factor-regulated tyrosine kinase substrate (SMED30034997) t-SNE clustered cells

Violin plots show distribution of expression levels for Hepatocyte growth factor-regulated tyrosine kinase substrate (SMED30034997) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Hepatocyte growth factor-regulated tyrosine kinase substrate (SMED30034997) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Hepatocyte growth factor-regulated tyrosine kinase substrate (SMED30034997) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034997

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30034997h1SMcG0017030 dd_Smed_v4_3184_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30034997h1SMcG0017030 dd_Smed_v4_3184_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30034997h1SMcG0017030 dd_Smed_v4_3184_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30034997h1SMcG0017030 Contig14251newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30034997h1SMcG0017030 Contig14251uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
epidermisSMED30034997h1SMcG0017030 dd_Smed_v4_1850_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30034997h1SMcG0017030 dd_Smed_v4_3184_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Human
Match: HGS (hepatocyte growth factor-regulated tyrosine kinase substrate [Source:HGNC Symbol;Acc:HGNC:4897])

HSP 1 Score: 276.944 bits (707), Expect = 9.665e-80
Identity = 119/213 (55.87%), Postives = 158/213 (74.18%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQL 219

HSP 2 Score: 185.267 bits (469), Expect = 6.376e-48
Identity = 116/230 (50.43%), Postives = 152/230 (66.09%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPT-RIIQANNESVNHVQNSVKNT-------------KDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            ++DPELARYLNRNYWE K  +     K+  PSAP     P  +  + +    N V+N +  T             +   +  +     E+FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  321 DIDPELARYLNRNYWEKKQEEAR---KSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 547
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Human
Match: HGS (hepatocyte growth factor-regulated tyrosine kinase substrate [Source:HGNC Symbol;Acc:HGNC:4897])

HSP 1 Score: 258.07 bits (658), Expect = 1.146e-78
Identity = 112/211 (53.08%), Postives = 149/211 (70.62%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K               WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLK--------------AWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQL 203
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Human
Match: HGS (hepatocyte growth factor-regulated tyrosine kinase substrate [Source:HGNC Symbol;Acc:HGNC:4897])

HSP 1 Score: 129.798 bits (325), Expect = 1.390e-32
Identity = 96/217 (44.24%), Postives = 123/217 (56.68%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPT-RIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            ++DPELARYLNRNYWE K  +     K+  PSAP     P  +  + +    N V+N +  T DS  +        E                                     ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:   41 DIDPELARYLNRNYWEKKQEEAR---KSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPET-DSQPIPPSGGPFSE-------------------------------------SINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 216
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Human
Match: TOM1 (target of myb1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11982])

HSP 1 Score: 92.8189 bits (229), Expect = 1.183e-20
Identity = 55/152 (36.18%), Postives = 82/152 (53.95%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            M F   NP      + IEKAT   L   DWA N+  CD+I + E   K A+ A+KK++ G+ N H V+ +L ++E+  KNCG   H  +A+QDF+    ++ ++ + +P   V  K L LIQ WA AFR       + + Y  L+ +G  FP
Sbjct:    1 MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFP 152
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Human
Match: TOM1 (target of myb1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11982])

HSP 1 Score: 93.5893 bits (231), Expect = 3.100e-19
Identity = 55/152 (36.18%), Postives = 82/152 (53.95%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            M F   NP      + IEKAT   L   DWA N+  CD+I + E   K A+ A+KK++ G+ N H V+ +L ++E+  KNCG   H  +A+QDF+    ++ ++ + +P   V  K L LIQ WA AFR       + + Y  L+ +G  FP
Sbjct:    1 MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFP 152
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Celegans
Match: hgrs-1 (Hepatocyte Growth factor-Regulated TK Substrate (HRS) family [Source:UniProtKB/TrEMBL;Acc:Q17796])

HSP 1 Score: 236.498 bits (602), Expect = 4.425e-66
Identity = 101/210 (48.10%), Postives = 149/210 (70.95%), Query Frame = 3 
Query:   81 FDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK--DPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYE 704
            F +++++AT   L+E +W   ++  DMIR GEV  K ++ AI+K+M H NPHVV ++L ++++  KNCG  +H E+AT++FM   K L+ E   D V++KSLE++Q WA AF ++ +Y ++  T+N +K  G  FP+L E+DAMF+++ APEW D   CYRC+  FS   RKHHCR CG IFCD+C+S+   +P++GIEKEVRVCE+CYE
Sbjct:    5 FQRVLDQATDSTLVEPNWEGIILCTDMIRSGEVPAKPSLQAIRKRMQHENPHVVNHTLLVLDACVKNCGHKVHAEVATREFMEDFKNLVTENKYDEVKNKSLEMLQCWATAFANKPEYKMVVDTHNLMKLAGFDFPSLKEADAMFMAQVAPEWADGPECYRCRSVFSVFTRKHHCRACGQIFCDKCSSRELALPQFGIEKEVRVCETCYE 214

HSP 2 Score: 103.605 bits (257), Expect = 2.064e-22
Identity = 87/228 (38.16%), Postives = 132/228 (57.89%), Query Frame = 2 
Query: 2084 LARYLNRNYW----ENKANDTSN-----SVKTTQPSAPTM-PNSPTRIIQANNESVNH--VQNSVKNTKDSLN--VSQISSEQEE----FLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMR 2713
            LARYLNR+YW    E K  D S+     S     PS P++ P+  + ++  ++ S+N      S+  T + LN  VS  +  Q +    +  +++  + +  NR+ SN  RGR + +DSA+Q LF  L  +H  +L  ++  D+QR Y+E+LQD L  + +AR+A+D +REEH  K++    E  +LRQ QM Q LE+MR KK   L  QR+ A+ R QQQ++EMAMR
Sbjct:  316 LARYLNRDYWQQKKEGKVEDWSSRSSALSATAPPPSEPSIAPSICSTLMGPDDNSLNADIAAMSLGGT-NGLNGTVSDDAKLQADDTMKWCQSIREQVSVMDNRIRSNLARGRPVFNDSAIQDLFTKLTELHSHVLSRMHTLDEQRGYYESLQDHLANIGEARQAIDEMREEHERKRQERMAEEQRLRQAQMQQTLEMMRMKKHAMLMEQREQALQRFQQQQQEMAMR 542
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Celegans
Match: hgrs-1 (Hepatocyte Growth factor-Regulated TK Substrate (HRS) family [Source:UniProtKB/TrEMBL;Acc:Q17796])

HSP 1 Score: 236.498 bits (602), Expect = 4.425e-66
Identity = 101/210 (48.10%), Postives = 149/210 (70.95%), Query Frame = 3 
Query:   81 FDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK--DPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYE 704
            F +++++AT   L+E +W   ++  DMIR GEV  K ++ AI+K+M H NPHVV ++L ++++  KNCG  +H E+AT++FM   K L+ E   D V++KSLE++Q WA AF ++ +Y ++  T+N +K  G  FP+L E+DAMF+++ APEW D   CYRC+  FS   RKHHCR CG IFCD+C+S+   +P++GIEKEVRVCE+CYE
Sbjct:    5 FQRVLDQATDSTLVEPNWEGIILCTDMIRSGEVPAKPSLQAIRKRMQHENPHVVNHTLLVLDACVKNCGHKVHAEVATREFMEDFKNLVTENKYDEVKNKSLEMLQCWATAFANKPEYKMVVDTHNLMKLAGFDFPSLKEADAMFMAQVAPEWADGPECYRCRSVFSVFTRKHHCRACGQIFCDKCSSRELALPQFGIEKEVRVCETCYE 214

HSP 2 Score: 103.605 bits (257), Expect = 2.064e-22
Identity = 87/228 (38.16%), Postives = 132/228 (57.89%), Query Frame = 2 
Query: 2084 LARYLNRNYW----ENKANDTSN-----SVKTTQPSAPTM-PNSPTRIIQANNESVNH--VQNSVKNTKDSLN--VSQISSEQEE----FLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMR 2713
            LARYLNR+YW    E K  D S+     S     PS P++ P+  + ++  ++ S+N      S+  T + LN  VS  +  Q +    +  +++  + +  NR+ SN  RGR + +DSA+Q LF  L  +H  +L  ++  D+QR Y+E+LQD L  + +AR+A+D +REEH  K++    E  +LRQ QM Q LE+MR KK   L  QR+ A+ R QQQ++EMAMR
Sbjct:  316 LARYLNRDYWQQKKEGKVEDWSSRSSALSATAPPPSEPSIAPSICSTLMGPDDNSLNADIAAMSLGGT-NGLNGTVSDDAKLQADDTMKWCQSIREQVSVMDNRIRSNLARGRPVFNDSAIQDLFTKLTELHSHVLSRMHTLDEQRGYYESLQDHLANIGEARQAIDEMREEHERKRQERMAEEQRLRQAQMQQTLEMMRMKKHAMLMEQREQALQRFQQQQQEMAMR 542
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Celegans
Match: C07A12.7 (pep chromosome:WBcel235:X:4517748:4521069:-1 gene:WBGene00015561.1 transcript:C07A12.7b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C07A12.7)

HSP 1 Score: 84.7297 bits (208), Expect = 4.794e-17
Identity = 57/156 (36.54%), Postives = 81/156 (51.92%), Query Frame = 3 
Query:   51 IMTFFSKNP---SFDKLIEKATSHLLLETD-WAANLMACDMIRQGEVTGKYAVTAIKKKMGHT---NPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK----DPVRSKSLELIQVWAHAFRHQSKY-GVIQSTYNFLKSQGCTFP 482
            +  FF  NP      + IE AT   LL T+ W  N+  CD I   E   + AV A+KK++ +    N  VV+Y+L ++E+  KNC    H  +  +DF+  +  LI  K      ++ + L LIQ WA AFR      GV+QS Y+ LKS+G  FP
Sbjct:   26 VSDFFQGNPFATPVGRKIELATDANLLATENWGLNMEICDFINGTEDGPRDAVRALKKRLHNAMSKNNAVVMYTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQIIQERVLSLIQAWADAFRGDPTLAGVVQS-YDDLKSKGVEFP 180
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Celegans
Match: C07A12.7 (pep chromosome:WBcel235:X:4517748:4521049:-1 gene:WBGene00015561.1 transcript:C07A12.7b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C07A12.7)

HSP 1 Score: 84.7297 bits (208), Expect = 4.794e-17
Identity = 57/156 (36.54%), Postives = 81/156 (51.92%), Query Frame = 3 
Query:   51 IMTFFSKNP---SFDKLIEKATSHLLLETD-WAANLMACDMIRQGEVTGKYAVTAIKKKMGHT---NPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK----DPVRSKSLELIQVWAHAFRHQSKY-GVIQSTYNFLKSQGCTFP 482
            +  FF  NP      + IE AT   LL T+ W  N+  CD I   E   + AV A+KK++ +    N  VV+Y+L ++E+  KNC    H  +  +DF+  +  LI  K      ++ + L LIQ WA AFR      GV+QS Y+ LKS+G  FP
Sbjct:   26 VSDFFQGNPFATPVGRKIELATDANLLATENWGLNMEICDFINGTEDGPRDAVRALKKRLHNAMSKNNAVVMYTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQIIQERVLSLIQAWADAFRGDPTLAGVVQS-YDDLKSKGVEFP 180
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Celegans
Match: C07A12.7 (pep chromosome:WBcel235:X:4517748:4521049:-1 gene:WBGene00015561.1 transcript:C07A12.7a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C07A12.7)

HSP 1 Score: 84.7297 bits (208), Expect = 6.497e-17
Identity = 57/156 (36.54%), Postives = 81/156 (51.92%), Query Frame = 3 
Query:   51 IMTFFSKNP---SFDKLIEKATSHLLLETD-WAANLMACDMIRQGEVTGKYAVTAIKKKMGHT---NPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK----DPVRSKSLELIQVWAHAFRHQSKY-GVIQSTYNFLKSQGCTFP 482
            +  FF  NP      + IE AT   LL T+ W  N+  CD I   E   + AV A+KK++ +    N  VV+Y+L ++E+  KNC    H  +  +DF+  +  LI  K      ++ + L LIQ WA AFR      GV+QS Y+ LKS+G  FP
Sbjct:   26 VSDFFQGNPFATPVGRKIELATDANLLATENWGLNMEICDFINGTEDGPRDAVRALKKRLHNAMSKNNAVVMYTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQIIQERVLSLIQAWADAFRGDPTLAGVVQS-YDDLKSKGVEFP 180
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Fly
Match: Hrs (gene:FBgn0031450 transcript:FBtr0089750)

HSP 1 Score: 241.891 bits (616), Expect = 1.076e-67
Identity = 112/222 (50.45%), Postives = 150/222 (67.57%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIK----GSG 722
            SFDK +E ATSHL LE DW + L+ CD I Q +VT K A  AIKKKM   NPH   YSL ++ES+ KNCG+ +H+E+ T++      + + E  P   VR K LEL+Q WA+AFR   KY  I+ T   LK++G TFP L E+DAMF ++TAP W D   C+RC++ F+   RKHHCR+CG +FC +CT+K+  +PKYGIEKEVRVC+ C+ +++    GSG
Sbjct:    5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEEVFTKENCEMFSSFL-ESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSG 225

HSP 2 Score: 160.229 bits (404), Expect = 3.594e-40
Identity = 102/214 (47.66%), Postives = 138/214 (64.49%), Query Frame = 2 
Query: 2075 DPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQ-EEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMR 2713
            +PELA+YLNR+YWE +    S+S+ +                   +                L V      Q +EF + +++ +EIFVNRM SN  RGRSI++DS+VQTLF+TL ++H Q L YI E DD+R ++E LQDKLTQ++D+R ALD LR+EH EK RR  EE  + RQ+QM QKL+IMR+KKQE+L YQRQLA+ R+Q+QEREM +R
Sbjct:  321 NPELAKYLNRSYWEQRKISESSSMASP------------------SAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLR 516
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Fly
Match: Hrs (gene:FBgn0031450 transcript:FBtr0089751)

HSP 1 Score: 241.891 bits (616), Expect = 1.076e-67
Identity = 112/222 (50.45%), Postives = 150/222 (67.57%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIK----GSG 722
            SFDK +E ATSHL LE DW + L+ CD I Q +VT K A  AIKKKM   NPH   YSL ++ES+ KNCG+ +H+E+ T++      + + E  P   VR K LEL+Q WA+AFR   KY  I+ T   LK++G TFP L E+DAMF ++TAP W D   C+RC++ F+   RKHHCR+CG +FC +CT+K+  +PKYGIEKEVRVC+ C+ +++    GSG
Sbjct:    5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEEVFTKENCEMFSSFL-ESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSG 225

HSP 2 Score: 160.229 bits (404), Expect = 3.594e-40
Identity = 102/214 (47.66%), Postives = 138/214 (64.49%), Query Frame = 2 
Query: 2075 DPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQ-EEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMR 2713
            +PELA+YLNR+YWE +    S+S+ +                   +                L V      Q +EF + +++ +EIFVNRM SN  RGRSI++DS+VQTLF+TL ++H Q L YI E DD+R ++E LQDKLTQ++D+R ALD LR+EH EK RR  EE  + RQ+QM QKL+IMR+KKQE+L YQRQLA+ R+Q+QEREM +R
Sbjct:  321 NPELAKYLNRSYWEQRKISESSSMASP------------------SAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLR 516
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Fly
Match: Hrs (gene:FBgn0031450 transcript:FBtr0089749)

HSP 1 Score: 160.229 bits (404), Expect = 1.250e-40
Identity = 102/214 (47.66%), Postives = 138/214 (64.49%), Query Frame = 2 
Query: 2075 DPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQ-EEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMR 2713
            +PELA+YLNR+YWE +    S+S+ +                   +                L V      Q +EF + +++ +EIFVNRM SN  RGRSI++DS+VQTLF+TL ++H Q L YI E DD+R ++E LQDKLTQ++D+R ALD LR+EH EK RR  EE  + RQ+QM QKL+IMR+KKQE+L YQRQLA+ R+Q+QEREM +R
Sbjct:  208 NPELAKYLNRSYWEQRKISESSSMASP------------------SAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLR 403

HSP 2 Score: 127.872 bits (320), Expect = 4.979e-30
Identity = 51/97 (52.58%), Postives = 71/97 (73.20%), Query Frame = 3 
Query:  444 TYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIK----GSG 722
            T   LK++G TFP L E+DAMF ++TAP W D   C+RC++ F+   RKHHCR+CG +FC +CT+K+  +PKYGIEKEVRVC+ C+ +++    GSG
Sbjct:   16 TMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSG 112
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Fly
Match: CG3529 (gene:FBgn0035995 transcript:FBtr0076461)

HSP 1 Score: 101.293 bits (251), Expect = 7.605e-22
Identity = 54/137 (39.42%), Postives = 80/137 (58.39%), Query Frame = 3 
Query:   93 IEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHT---NPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            IE AT   L   +WAAN+  CDMI +   T + A+ AI+K++      N  VV+Y+L ++E+  KNCG   H  +A +DF+N++  LI  K DP   ++ K L LIQ+WA AF++Q     +   Y  LK++G  FP
Sbjct:   22 IEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLTVLETCVKNCGKAFHVLVAQKDFINELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNGVTQMYMELKNKGIEFP 158
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Fly
Match: CG3529 (gene:FBgn0035995 transcript:FBtr0331582)

HSP 1 Score: 101.293 bits (251), Expect = 8.009e-22
Identity = 54/137 (39.42%), Postives = 80/137 (58.39%), Query Frame = 3 
Query:   93 IEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHT---NPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            IE AT   L   +WAAN+  CDMI +   T + A+ AI+K++      N  VV+Y+L ++E+  KNCG   H  +A +DF+N++  LI  K DP   ++ K L LIQ+WA AF++Q     +   Y  LK++G  FP
Sbjct:   22 IEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLTVLETCVKNCGKAFHVLVAQKDFINELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNGVTQMYMELKNKGIEFP 158
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Zebrafish
Match: hgs (hepatocyte growth factor-regulated tyrosine kinase substrate [Source:ZFIN;Acc:ZDB-GENE-030131-6107])

HSP 1 Score: 278.1 bits (710), Expect = 1.230e-80
Identity = 120/211 (56.87%), Postives = 159/211 (75.36%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIK-EKDP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYE 704
            +F++L+EKATS LLLETDW + L  CD+IRQG+   KYA+ AIKKK+   NPHV +Y+L ++ES+ KNCG TIHDE+A++  M ++K L K + +P V++K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE C+E
Sbjct:    7 TFERLLEKATSQLLLETDWESILQICDLIRQGDTQAKYAIGAIKKKLNDKNPHVALYALEVLESVVKNCGQTIHDEVASKQTMEELKELFKKQPEPNVKNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFE 217

HSP 2 Score: 187.578 bits (475), Expect = 5.528e-49
Identity = 117/222 (52.70%), Postives = 151/222 (68.02%), Query Frame = 2 
Query: 2051 SSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            S+    E+DPELARYLNR YWE K  +     K+  PSAP  P S    +  +    +HV     N  +     +     E+FL AL++S+  F+NRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL+ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  317 SAPSAEEVDPELARYLNRTYWEKKQEEVR---KSPTPSAPA-PVSLAEPVPVSQPVESHVPVQPINIVEQYQNGESEENHEQFLKALQNSVTTFLNRMKSNHMRGRSITNDSAVLSLFQSINNMHPQLLEILNQLDEKRLYYEGLQDKLAQVRDARAALNALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQMRL 534
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Zebrafish
Match: tom1 (target of myb1 membrane trafficking protein [Source:ZFIN;Acc:ZDB-GENE-060721-1])

HSP 1 Score: 91.6633 bits (226), Expect = 6.394e-19
Identity = 54/152 (35.53%), Postives = 83/152 (54.61%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKK-MGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQM---KALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            M FF+ NP      +LIE ATS  L   DW  N+  CD++ + +   K AV AIKK+ +G+ N   V+ +L+++E+  KNCG   H  ++T+DF+  +     L K   PV  + + L +IQ WA AFR  +    + + Y  L+ +G  FP
Sbjct:    1 MEFFTGNPFSTPVGQLIEHATSSSLPSEDWGLNMEICDLVNEAQEGPKDAVRAIKKRILGNRNFKEVMLALSVLEACVKNCGHKFHVYVSTRDFVENVLVQTILPKNNAPVVLQDRVLIMIQAWADAFRSSTDLTGVVTVYEDLRRRGVEFP 152
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Zebrafish
Match: tom1 (target of myb1 membrane trafficking protein [Source:ZFIN;Acc:ZDB-GENE-060721-1])

HSP 1 Score: 91.6633 bits (226), Expect = 7.207e-19
Identity = 54/152 (35.53%), Postives = 83/152 (54.61%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKK-MGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQM---KALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            M FF+ NP      +LIE ATS  L   DW  N+  CD++ + +   K AV AIKK+ +G+ N   V+ +L+++E+  KNCG   H  ++T+DF+  +     L K   PV  + + L +IQ WA AFR  +    + + Y  L+ +G  FP
Sbjct:    1 MEFFTGNPFSTPVGQLIEHATSSSLPSEDWGLNMEICDLVNEAQEGPKDAVRAIKKRILGNRNFKEVMLALSVLEACVKNCGHKFHVYVSTRDFVENVLVQTILPKNNAPVVLQDRVLIMIQAWADAFRSSTDLTGVVTVYEDLRRRGVEFP 152
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Zebrafish
Match: stam (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:ZFIN;Acc:ZDB-GENE-031118-123])

HSP 1 Score: 88.1965 bits (217), Expect = 1.482e-17
Identity = 45/146 (30.82%), Postives = 78/146 (53.42%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQV-WAHAFRHQSKYGVIQSTYNFLKSQGCTFPTL 488
            M  F+ NP FD+ +EKATS +    DW   L  CD I Q     K  + +I +++ H +PHV + +L L+ +   NCG   H E+ +++F +++  ++ +  P   + L+ + V WA  FR+  +  +I +    L+ QG  FP +
Sbjct:    1 MPLFTTNP-FDQDVEKATSEMNTAEDWGLILDICDKIGQSRTGPKECLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSREFASEVSNVLNKGHPKVCEKLKALMVEWAEDFRNDPQLSLISAMIKNLREQGVIFPAV 145
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Zebrafish
Match: TOM1L2 (target of myb1 like 2 membrane trafficking protein [Source:NCBI gene;Acc:100535615])

HSP 1 Score: 84.7297 bits (208), Expect = 1.538e-16
Identity = 54/160 (33.75%), Postives = 82/160 (51.25%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMN--QMKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAM 506
            M F   NP      + IEKAT   L   DW  N+  CD+I + E   + A+ A+KK++ G+ N   V+ +L ++E+  KNCG   H  +A +DF+    +K +  + +P    + K L LIQ WA AFR       +   Y  LK +G  FP + + DA+
Sbjct:    1 MEFLLGNPYSTPVGQCIEKATDGSLQNEDWTLNMEICDIINETEEGPRDAMRAVKKRLNGNRNFREVMLALTVLETCVKNCGHRFHVHVANRDFIEGVMVKIISPKNNPPAIAQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGVEFP-MADLDAL 159
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Xenopus
Match: ighx (immunoglobulin heavy chain precursor [Source:Xenbase;Acc:XB-GENE-479174])

HSP 1 Score: 276.174 bits (705), Expect = 7.781e-80
Identity = 129/257 (50.19%), Postives = 176/257 (68.48%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI--KGSGH----VQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +F++L++KATS LLLETDW + L  CDMIRQG+   KYAV +IKKK+   NPHV +++L ++ES+ KNCG  +HDE+A +  M ++K L K + +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +  KG G     V+   + +    + +S+     D S  Q+E E+
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDMIRQGDTQAKYAVASIKKKINDKNPHVALFALEVLESVVKNCGQHVHDEVANKQTMEELKELQKRQVEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHNFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKGEGKSASGVELPPEYLTSPLSQQSQMPPKKDESALQEEEEL 263

HSP 2 Score: 186.808 bits (473), Expect = 1.241e-48
Identity = 116/216 (53.70%), Postives = 154/216 (71.30%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            E+DPELARYLNRNYWE K  +     K+  PSAP +P S   ++Q  +  V  V    +N +   N        E+FL AL++++  F+NRM SN+ RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL+ALR+EHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  +RL
Sbjct:  321 EIDPELARYLNRNYWEKKQEEVR---KSPTPSAP-VPISEPAVLQGGDVPVT-VMEQYQNGESEEN-------HEQFLKALQNAVTTFLNRMKSNQMRGRSITNDSAVLSLFQSINNMHPQLLEMLNQLDERRLYYEGLQDKLAQIRDARGALNALRDEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQLRL 524
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Xenopus
Match: ighx (immunoglobulin heavy chain precursor [Source:Xenbase;Acc:XB-GENE-479174])

HSP 1 Score: 264.618 bits (675), Expect = 4.331e-79
Identity = 126/249 (50.60%), Postives = 168/249 (67.47%), Query Frame = 3 
Query:  102 ATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI--KGSGH----VQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            ATS LLLETDW + L  CDMIRQG+   KYAV +IKKK+   NPHV +++L ++ES+ KNCG  +HDE+A +  M ++K L K + +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +  KG G     V+   + +    + +S+     D S  Q+E E+
Sbjct:   13 ATSQLLLETDWESILQICDMIRQGDTQAKYAVASIKKKINDKNPHVALFALEVLESVVKNCGQHVHDEVANKQTMEELKELQKRQVEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHNFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKGEGKSASGVELPPEYLTSPLSQQSQMPPKKDESALQEEEEL 261

HSP 2 Score: 74.3294 bits (181), Expect = 2.662e-13
Identity = 43/106 (40.57%), Postives = 62/106 (58.49%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDS 2386
            E+DPELARYLNRNYWE K  +     K+  PSAP +P S   ++Q  +     ++   +N +   N        E+FL AL++++  F+NRM SN+ RGR IA D+
Sbjct:  319 EIDPELARYLNRNYWEKKQEEVR---KSPTPSAP-VPISEPAVLQGGDVPSQPIKKQYQNGESEEN-------HEQFLKALQNAVTTFLNRMKSNQMRGR-IARDA 412
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Xenopus
Match: ighx (immunoglobulin heavy chain precursor [Source:Xenbase;Acc:XB-GENE-479174])

HSP 1 Score: 268.47 bits (685), Expect = 4.260e-77
Identity = 127/251 (50.60%), Postives = 170/251 (67.73%), Query Frame = 3 
Query:   96 EKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI--KGSGH----VQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +KATS LLLETDW + L  CDMIRQG+   KYAV +IKKK+   NPHV +++L ++ES+ KNCG  +HDE+A +  M ++K L K + +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +  KG G     V+   + +    + +S+     D S  Q+E E+
Sbjct:   13 DKATSQLLLETDWESILQICDMIRQGDTQAKYAVASIKKKINDKNPHVALFALEVLESVVKNCGQHVHDEVANKQTMEELKELQKRQVEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHNFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKGEGKSASGVELPPEYLTSPLSQQSQMPPKKDESALQEEEEL 263

HSP 2 Score: 182.956 bits (463), Expect = 2.240e-47
Identity = 114/216 (52.78%), Postives = 151/216 (69.91%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            E+DPELARYLNRNYWE K  +     K+  PSAP +P +   +   +  SV   QN            +     E+FL AL++++  F+NRM SN+ RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL+ALR+EHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  +RL
Sbjct:  321 EIDPELARYLNRNYWEKKQEEVR---KSPTPSAP-VPITIHTLFPKSPSSVQQYQNG-----------ESEENHEQFLKALQNAVTTFLNRMKSNQMRGRSITNDSAVLSLFQSINNMHPQLLEMLNQLDERRLYYEGLQDKLAQIRDARGALNALRDEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQLRL 521
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Xenopus
Match: ighx (immunoglobulin heavy chain precursor [Source:Xenbase;Acc:XB-GENE-479174])

HSP 1 Score: 268.085 bits (684), Expect = 4.437e-77
Identity = 127/251 (50.60%), Postives = 170/251 (67.73%), Query Frame = 3 
Query:   96 EKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI--KGSGH----VQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +KATS LLLETDW + L  CDMIRQG+   KYAV +IKKK+   NPHV +++L ++ES+ KNCG  +HDE+A +  M ++K L K + +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +  KG G     V+   + +    + +S+     D S  Q+E E+
Sbjct:   13 DKATSQLLLETDWESILQICDMIRQGDTQAKYAVASIKKKINDKNPHVALFALEVLESVVKNCGQHVHDEVANKQTMEELKELQKRQVEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHNFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKGEGKSASGVELPPEYLTSPLSQQSQMPPKKDESALQEEEEL 263

HSP 2 Score: 186.422 bits (472), Expect = 1.529e-48
Identity = 115/216 (53.24%), Postives = 154/216 (71.30%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            E+DPELARYLNRNYWE K  +     K+  PSAP +P S   ++Q  +  V  ++ S     +S          E+FL AL++++  F+NRM SN+ RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL+ALR+EHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  +RL
Sbjct:  321 EIDPELARYLNRNYWEKKQEEVR---KSPTPSAP-VPISEPAVLQGGDVPVTVMEVSQYQNGES------EENHEQFLKALQNAVTTFLNRMKSNQMRGRSITNDSAVLSLFQSINNMHPQLLEMLNQLDERRLYYEGLQDKLAQIRDARGALNALRDEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQLRL 526
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Xenopus
Match: ighx (immunoglobulin heavy chain precursor [Source:Xenbase;Acc:XB-GENE-479174])

HSP 1 Score: 268.47 bits (685), Expect = 7.417e-77
Identity = 127/251 (50.60%), Postives = 170/251 (67.73%), Query Frame = 3 
Query:   96 EKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI--KGSGH----VQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +KATS LLLETDW + L  CDMIRQG+   KYAV +IKKK+   NPHV +++L ++ES+ KNCG  +HDE+A +  M ++K L K + +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +  KG G     V+   + +    + +S+     D S  Q+E E+
Sbjct:   13 DKATSQLLLETDWESILQICDMIRQGDTQAKYAVASIKKKINDKNPHVALFALEVLESVVKNCGQHVHDEVANKQTMEELKELQKRQVEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHNFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKGEGKSASGVELPPEYLTSPLSQQSQMPPKKDESALQEEEEL 263

HSP 2 Score: 184.496 bits (467), Expect = 9.850e-48
Identity = 117/233 (50.21%), Postives = 155/233 (66.52%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVN-----------------HVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            E+DPELARYLNRNYWE K  +     K+  PSAP +P S   ++Q  +  V                  H  N  +N +   N        E+FL AL++++  F+NRM SN+ RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL+ALR+EHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  +RL
Sbjct:  321 EIDPELARYLNRNYWEKKQEEVR---KSPTPSAP-VPISEPAVLQGGDVPVTVMETLPQTLFLCFNTSYHFTNQYQNGESEEN-------HEQFLKALQNAVTTFLNRMKSNQMRGRSITNDSAVLSLFQSINNMHPQLLEMLNQLDERRLYYEGLQDKLAQIRDARGALNALRDEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQLRL 542
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Mouse
Match: Hgs (HGF-regulated tyrosine kinase substrate [Source:MGI Symbol;Acc:MGI:104681])

HSP 1 Score: 276.944 bits (707), Expect = 6.389e-80
Identity = 126/257 (49.03%), Postives = 174/257 (67.70%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI------KGSGHVQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +      K S   +   + +    + +S+     D +  Q+E E+
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKASSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEEL 263

HSP 2 Score: 188.348 bits (477), Expect = 3.394e-49
Identity = 121/246 (49.19%), Postives = 159/246 (64.63%), Query Frame = 2 
Query: 2018 PANQIGFNGIYSSLDTSE-MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSE------------QEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            PA  +  + + SS   +E +DPELARYLNRNYWE K  +   + K+  PSAP     P       + + N +  +     DS  ++  S               E+FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  303 PAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEE---ARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETDSQPITPCSGPFSEYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 545
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Mouse
Match: Hgs (HGF-regulated tyrosine kinase substrate [Source:MGI Symbol;Acc:MGI:104681])

HSP 1 Score: 276.944 bits (707), Expect = 6.446e-80
Identity = 126/257 (49.03%), Postives = 174/257 (67.70%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI------KGSGHVQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +      K S   +   + +    + +S+     D +  Q+E E+
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKASSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEEL 263

HSP 2 Score: 189.119 bits (479), Expect = 2.105e-49
Identity = 124/247 (50.20%), Postives = 162/247 (65.59%), Query Frame = 2 
Query: 2018 PANQIGFNGIYSSLDTSE-MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQIS---SEQ----------EEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            PA  +  + + SS   +E +DPELARYLNRNYWE K  +   + K+  PSAP     P       + + N +  +     DS  ++  S   SEQ          E+FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  303 PAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEE---ARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETDSQPITPCSGPFSEQYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 546
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Mouse
Match: Hgs (HGF-regulated tyrosine kinase substrate [Source:MGI Symbol;Acc:MGI:104681])

HSP 1 Score: 257.684 bits (657), Expect = 5.752e-79
Identity = 112/211 (53.08%), Postives = 150/211 (71.09%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K              EL++ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELK--------------ELLKAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQL 203
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Mouse
Match: Hgs (HGF-regulated tyrosine kinase substrate [Source:MGI Symbol;Acc:MGI:104681])

HSP 1 Score: 132.109 bits (331), Expect = 1.697e-33
Identity = 99/234 (42.31%), Postives = 130/234 (55.56%), Query Frame = 2 
Query: 2018 PANQIGFNGIYSSLDTSE-MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            PA  +  + + SS   +E +DPELARYLNRNYWE K  +   + K+  PSAP     P       + + N +  +     DS  ++  S    E                                     ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:   25 PAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEE---ARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETDSQPITPCSGPFSE-------------------------------------SINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 218
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Mouse
Match: Tom1 (target of myb1 trafficking protein [Source:MGI Symbol;Acc:MGI:1338026])

HSP 1 Score: 94.3597 bits (233), Expect = 1.545e-19
Identity = 56/152 (36.84%), Postives = 80/152 (52.63%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKK-MGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            M F   NP      + IEKAT   L   DWA N+  CD+I + E   K A  A+KK+ MG+ N H V+ +L ++E+  KNCG   H  +A QDF+    ++ ++ + +P   V  K L LIQ WA AFR       + + Y  L+ +G  FP
Sbjct:    1 MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIMGNKNFHEVMLALTVLETCVKNCGHRFHVLVANQDFVENVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVAVYEDLRRKGLEFP 152
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. UniProt/SwissProt
Match: sp|Q99LI8|HGS_MOUSE (Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Mus musculus OX=10090 GN=Hgs PE=1 SV=2)

HSP 1 Score: 276.944 bits (707), Expect = 4.469e-79
Identity = 126/257 (49.03%), Postives = 174/257 (67.70%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI------KGSGHVQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +      K S   +   + +    + +S+     D +  Q+E E+
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKASSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEEL 263

HSP 2 Score: 188.348 bits (477), Expect = 2.374e-48
Identity = 121/246 (49.19%), Postives = 159/246 (64.63%), Query Frame = 2 
Query: 2018 PANQIGFNGIYSSLDTSE-MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSE------------QEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            PA  +  + + SS   +E +DPELARYLNRNYWE K  +   + K+  PSAP     P       + + N +  +     DS  ++  S               E+FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  303 PAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEE---ARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETDSQPITPCSGPFSEYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 545
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. UniProt/SwissProt
Match: sp|O14964|HGS_HUMAN (Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1)

HSP 1 Score: 276.944 bits (707), Expect = 4.641e-79
Identity = 119/213 (55.87%), Postives = 158/213 (74.18%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQL 219

HSP 2 Score: 185.267 bits (469), Expect = 3.062e-47
Identity = 116/230 (50.43%), Postives = 152/230 (66.09%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPT-RIIQANNESVNHVQNSVKNT-------------KDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            ++DPELARYLNRNYWE K  +     K+  PSAP     P  +  + +    N V+N +  T             +   +  +     E+FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  321 DIDPELARYLNRNYWEKKQEEAR---KSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 547
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. UniProt/SwissProt
Match: sp|Q9JJ50|HGS_RAT (Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Rattus norvegicus OX=10116 GN=Hgs PE=1 SV=1)

HSP 1 Score: 276.559 bits (706), Expect = 5.455e-79
Identity = 119/213 (55.87%), Postives = 158/213 (74.18%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQL 219

HSP 2 Score: 185.267 bits (469), Expect = 2.459e-47
Identity = 123/247 (49.80%), Postives = 161/247 (65.18%), Query Frame = 2 
Query: 2018 PANQIGFNGIYSSLDTSE-MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQIS---SEQ----------EEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            PA  +  + + SS   +E +DPELARYLNRNYWE K  +   + K+  PSAP     P       + + N +  +     DS  ++  S   SEQ          E+FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N+ HPQLL+ +N  D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  303 PAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEE---ARKSPTPSAPVPLTEPAAQPGEGHTAPNSMVEAPLPETDSQPITSCSGPFSEQYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINSTHPQLLELLNRLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 546
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. UniProt/SwissProt
Match: sp|Q0V8S0|HGS_BOVIN (Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Bos taurus OX=9913 GN=HGS PE=2 SV=1)

HSP 1 Score: 276.559 bits (706), Expect = 6.460e-79
Identity = 118/213 (55.40%), Postives = 159/213 (74.65%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV++IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE C+E +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQL 219

HSP 2 Score: 186.037 bits (471), Expect = 1.407e-47
Identity = 127/257 (49.42%), Postives = 165/257 (64.20%), Query Frame = 2 
Query: 1988 PIGKSVSQPTPANQIGFNGIYSSLDTSE-MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISS---------EQEE----FLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            P+  S     PA+ +  + + SS   +E +DPELARYLNRNYWE K  +     K+  PSAP     PT      +    +V+ S+  T D   V+   +         E EE    FL AL++++  FVNRM SN  RGRSI +DSAV +LF ++N MHPQLL+ +N+ D++R Y+E LQDKL Q+RDAR AL ALREEHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  296 PVASSA---PPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEAR---KSPTPSAPVPLTEPTAQPGEGHAIPANVETSLPET-DPQAVTAAGAAFSEQYQNGESEESHAQFLKALQNAVTTFVNRMKSNHVRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRL 545
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. UniProt/SwissProt
Match: sp|Q960X8|HRS_DROME (Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster OX=7227 GN=Hrs PE=1 SV=1)

HSP 1 Score: 241.891 bits (616), Expect = 1.079e-66
Identity = 112/222 (50.45%), Postives = 150/222 (67.57%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIK----GSG 722
            SFDK +E ATSHL LE DW + L+ CD I Q +VT K A  AIKKKM   NPH   YSL ++ES+ KNCG+ +H+E+ T++      + + E  P   VR K LEL+Q WA+AFR   KY  I+ T   LK++G TFP L E+DAMF ++TAP W D   C+RC++ F+   RKHHCR+CG +FC +CT+K+  +PKYGIEKEVRVC+ C+ +++    GSG
Sbjct:    5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEEVFTKENCEMFSSFL-ESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSG 225

HSP 2 Score: 160.229 bits (404), Expect = 3.603e-39
Identity = 102/214 (47.66%), Postives = 138/214 (64.49%), Query Frame = 2 
Query: 2075 DPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQ-EEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMR 2713
            +PELA+YLNR+YWE +    S+S+ +                   +                L V      Q +EF + +++ +EIFVNRM SN  RGRSI++DS+VQTLF+TL ++H Q L YI E DD+R ++E LQDKLTQ++D+R ALD LR+EH EK RR  EE  + RQ+QM QKL+IMR+KKQE+L YQRQLA+ R+Q+QEREM +R
Sbjct:  321 NPELAKYLNRSYWEQRKISESSSMASP------------------SAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLR 516
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. TrEMBL
Match: C3Z6W8 (Uncharacterized protein (Fragment) OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_259935 PE=4 SV=1)

HSP 1 Score: 283.108 bits (723), Expect = 4.810e-85
Identity = 124/212 (58.49%), Postives = 163/212 (76.89%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +FD+L+EKATS LLLE DW A L  CD IRQG+VT KYA+ AI+KK+   NPHV +Y+L ++ES+ KNCGS +H EIA ++ M +M+ L K   D VR+K LELIQVW+HAFR++  Y V+Q TY  +K +GC+FP L ESDAMF +E APEW+D D C+RC++ F  ++RKHHCR CG +FC +C+SK S IPK+GIEKEVRVC+SC+E +
Sbjct:    6 NFDRLLEKATSQLLLEPDWDATLQICDSIRQGDVTPKYAIPAIRKKVYDRNPHVSLYALQVLESVVKNCGSPVHQEIAQKEVMEEMRDLAKRSADNVRNKVLELIQVWSHAFRNEPSYRVVQDTYQIMKMEGCSFPELRESDAMFAAEKAPEWKDGDVCHRCRVQFGMVQRKHHCRACGQVFCGKCSSKNSIIPKFGIEKEVRVCDSCFEEL 217
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. TrEMBL
Match: A0A0M8ZXA5 (Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Melipona quadrifasciata OX=166423 GN=WN51_03655 PE=4 SV=1)

HSP 1 Score: 295.819 bits (756), Expect = 3.856e-83
Identity = 127/231 (54.98%), Postives = 168/231 (72.73%), Query Frame = 3 
Query:   60 FFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK--DPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDV 746
             F  +P+FDKL+EKATSH  LE DW A L  CD+IRQG+V  K A+ AIKKKM + NPHV +Y+L ++ES  KNCG+ IHDEI T+ +M Q+K L+K    + V+ K+LELIQ WAHAFR+  KY  +Q T N +K++G  FPTL ESDAMF+++TAP W D D C+RC++ F  ++RKHHCR CG +FC++C+SK + +PK+GIEKEVRVCESCY  +      Q  ED+
Sbjct:    1 MFRNSPNFDKLLEKATSHYQLEPDWVAILQICDLIRQGDVQPKIALAAIKKKMTNANPHVALYALLVLESCVKNCGTLIHDEIGTKQYMEQLKELVKTTTHENVKLKTLELIQAWAHAFRNSPKYRAVQDTLNIMKAEGHKFPTLKESDAMFIADTAPAWADGDVCHRCRVTFGMVQRKHHCRACGQVFCNQCSSKSTTLPKFGIEKEVRVCESCYGKVNKPSTAQIKEDL 231

HSP 2 Score: 190.66 bits (483), Expect = 2.302e-46
Identity = 118/222 (53.15%), Postives = 156/222 (70.27%), Query Frame = 2 
Query: 2051 SSLDTSEMDPELARYLNRNYWE---NKANDTSNSVKTTQPSAPTMPNS-PTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREM 2704
            S  + +E+DPELA+YLNR  WE   +   + S+    T PSAP + +  P ++I A  ++                  ++ ++ EEF++AL+S +EIFVNRM SN  RGRSIA+DS+VQTLFL + AMH +LL+YI EQDD R Y+E LQDKLTQ++DAR ALDALREEHREK RR+ EEA + RQ+ M QKL IMR+KKQE+L YQRQLA+ ++Q+QEREM
Sbjct:  305 SPQEETEVDPELAKYLNRKRWELRQSALEEHSSRADVTSPSAPNISSPMPQKVIIAKQQN-----------------GEVDTQMEEFVNALRSQVEIFVNRMKSNSSRGRSIANDSSVQTLFLNITAMHSRLLRYIQEQDDSRVYYEGLQDKLTQMKDARAALDALREEHREKLRRQAEEAERQRQMLMAQKLAIMRKKKQEYLQYQRQLALQKIQEQEREM 509
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. TrEMBL
Match: U6D5X6 (Uncharacterized protein (Fragment) OS=Neovison vison OX=452646 GN=F5H5Y5 PE=2 SV=1)

HSP 1 Score: 274.248 bits (700), Expect = 7.681e-81
Identity = 126/257 (49.03%), Postives = 175/257 (68.09%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI------KGSGHVQFNEDVIVRNFTPESK-ETTSDASRAQKEREM 821
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV++IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +      K S   +   + +    + +S+     D +  Q+E E+
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKASSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEEL 263
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. TrEMBL
Match: A0A2J7Q3T0 (Hepatocyte growth factor-regulated tyrosine kinase substrate (Fragment) OS=Cryptotermes secundus OX=105785 GN=B7P43_G02735 PE=4 SV=1)

HSP 1 Score: 281.567 bits (719), Expect = 1.259e-80
Identity = 128/258 (49.61%), Postives = 181/258 (70.16%), Query Frame = 3 
Query:   51 IMTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK--DPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI-KGSGHVQFNEDVIVRNFTPESKETTSDASRAQKER 815
            +  F S   +FDKL++KATS+L LE DW A L  CD+IRQG+V  KYA+ AIKKK+ + NPH+ ++ L ++ES  K+CG+ IHDEI T+ +M Q++ L+K    D V++K LELIQ WA+AFR+  KY  +Q T N +K++GC FP L ESDAMF ++TAPEW D D C+RC++ F  ++RKHHCR CG +FC +C+SK S +PK+GIEKEVRVCE+C+E+  K +   Q  +  +     P    ++S A ++QK+R
Sbjct:   36 VRMFRSTTSNFDKLLDKATSNLRLEPDWPAILQICDLIRQGDVQPKYALAAIKKKLYNANPHIAMFGLQVLESCVKHCGNPIHDEIGTKQYMEQLRDLVKSTSHDDVKNKVLELIQAWAYAFRNSPKYRAVQDTVNIMKTEGCKFPALKESDAMFSADTAPEWADGDVCHRCRVQFGMMQRKHHCRACGQVFCAQCSSKTSTLPKFGIEKEVRVCEACFEAFNKATPATQKTDGEL-----PAEYVSSSLAQQSQKKR 288

HSP 2 Score: 183.726 bits (465), Expect = 1.058e-45
Identity = 116/247 (46.96%), Postives = 159/247 (64.37%), Query Frame = 2 
Query: 2012 PTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTS------------------NSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQER 2698
            PT  N  G   +   +   ++DPELARYLNR+YWE + ++ +                  +S  + QPSAP    +P+  +Q  +E+                  +  +E EEF++ LK  +EIFVNRM SN  RGRSIA+DS+VQTLF+ + AMH +LL++I +QDD R Y+E LQDKL Q++DAR ALDALREE+REK RR+ EEA ++RQ+QM  KLEIMR+KKQE+L YQRQLA+ ++Q+QER
Sbjct:  310 PTVENISGSPNLQQVVPEDDVDPELARYLNRSYWEQRQSEEAQQHEKQLHHVSDRNGSRVDSPLSQQPSAPMSSTTPSNKLQHRHEN-----------------GETDTEMEEFVATLKMQVEIFVNRMKSNSSRGRSIANDSSVQTLFMNITAMHSRLLKHIQQQDDSRVYYEELQDKLAQVKDARAALDALREEYREKLRRQAEEAERIRQMQMAHKLEIMRKKKQEYLQYQRQLALQKIQEQER 539
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. TrEMBL
Match: B4DFP5 (cDNA FLJ57484, highly similar to Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 PE=2 SV=1)

HSP 1 Score: 269.626 bits (688), Expect = 2.023e-80
Identity = 119/213 (55.87%), Postives = 158/213 (74.18%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPV--RSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   KYAV +IKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A +  M ++K L+K +  V  R+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE CYE +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMGELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQL 219
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Cavefish
Match: hgs (hepatocyte growth factor-regulated tyrosine kinase substrate [Source:ZFIN;Acc:ZDB-GENE-030131-6107])

HSP 1 Score: 178.333 bits (451), Expect = 2.561e-46
Identity = 111/222 (50.00%), Postives = 148/222 (66.67%), Query Frame = 2 
Query: 2051 SSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            S+    ++DPELARYLNR YWE K  +     K+  PSAP  P      +  +    +H      N  +     +     E+FL AL++++  F+NRM SN  RGRSI +DSAV +LF ++N MHPQLL  +N+ D++R Y+E LQDKL Q+RDAR AL+ALR+EHREK RR  EEA + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  +RL
Sbjct:  249 SAPSAEDVDPELARYLNRTYWEKKQEEVR---KSPTPSAPA-PVPLAEPLPVSQPVESHAPVQPINIVEQYQNGESEENHEQFLKALQNAVTTFLNRMKSNHMRGRSITNDSAVLSLFQSINNMHPQLLDILNQLDEKRLYYEGLQDKLAQVRDARAALNALRDEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQLRL 466

HSP 2 Score: 168.703 bits (426), Expect = 4.474e-43
Identity = 71/122 (58.20%), Postives = 91/122 (74.59%), Query Frame = 3 
Query:  348 KEKDP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            K+ +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE C+E +
Sbjct:   30 KQTEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQL 151
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Cavefish
Match: stam (signal transducing adaptor molecule [Source:NCBI gene;Acc:103028487])

HSP 1 Score: 90.5077 bits (223), Expect = 1.958e-18
Identity = 46/146 (31.51%), Postives = 79/146 (54.11%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQV-WAHAFRHQSKYGVIQSTYNFLKSQGCTFPTL 488
            M  F+ NP FD+ +EKATS +    DW   L  CD I Q     K  + +I +++ H +PHV + +L L+ +   NCG   H E+ +++F +++  ++ +  P   + L+ + V WA  FR+  +  +I +    L+ QG TFP +
Sbjct:    1 MPLFTSNP-FDQDVEKATSEMNTAEDWGLILDICDKIGQSRTGPKECLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSREFASEVSNVLNKGHPKVCEKLKALMVEWAEDFRNDPQLSLISAMIKNLREQGVTFPAV 145
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Cavefish
Match: tom1l2 (target of myb1 like 2 membrane trafficking protein [Source:ZFIN;Acc:ZDB-GENE-061013-3])

HSP 1 Score: 88.1965 bits (217), Expect = 1.118e-17
Identity = 53/152 (34.87%), Postives = 79/152 (51.97%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            M F   NP      + IEKAT   L   DW  N+  CD+I + E   K A+ A+KK++ G+ N   V+ +L ++E+  KNCG   H  + T+DF++   +K +  + +P   V+ K L LIQ WA AFR       +   Y  +K +G  FP
Sbjct:   18 MEFLLGNPYSTPVGQCIEKATDGSLQSEDWTLNMEICDIINETEDGPKDAIRAVKKRLNGNKNYREVMLTLTVLETCVKNCGYRFHALVTTRDFIDGVLVKVISPKNNPPAIVQDKVLALIQAWADAFRSSPDLTGVVHVYEEMKRKGIEFP 169
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Cavefish
Match: TOM1L2 (target of myb1 like 2 membrane trafficking protein [Source:NCBI gene;Acc:103026886])

HSP 1 Score: 88.1965 bits (217), Expect = 1.129e-17
Identity = 57/160 (35.62%), Postives = 84/160 (52.50%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAM 506
            M F   NP      + IEKAT   L   DW  N+  CD+I + E   K A+ A+KK++  + N   V+ +L ++E+  KNCG   H  IAT+DF++   +K +  + +P   V+ K L LIQ WA AFR       +   Y  LK +G  FP + + DA+
Sbjct:    1 MEFLLGNPFSTPVGQCIEKATDGSLQNEDWTLNMEICDIINETEEGPKDAIRAVKKRLNANRNFREVMLALTVLETCVKNCGHRFHVLIATRDFIDGVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGIEFP-MADLDAL 159
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Cavefish
Match: TOM1L2 (target of myb1 like 2 membrane trafficking protein [Source:NCBI gene;Acc:103026886])

HSP 1 Score: 88.1965 bits (217), Expect = 1.196e-17
Identity = 57/160 (35.62%), Postives = 84/160 (52.50%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAM 506
            M F   NP      + IEKAT   L   DW  N+  CD+I + E   K A+ A+KK++  + N   V+ +L ++E+  KNCG   H  IAT+DF++   +K +  + +P   V+ K L LIQ WA AFR       +   Y  LK +G  FP + + DA+
Sbjct:    1 MEFLLGNPFSTPVGQCIEKATDGSLQNEDWTLNMEICDIINETEEGPKDAIRAVKKRLNANRNFREVMLALTVLETCVKNCGHRFHVLIATRDFIDGVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGIEFP-MADLDAL 159
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Sea Lamprey
Match: tom1l2 (target of myb1 like 2 membrane trafficking protein [Source:ZFIN;Acc:ZDB-GENE-061013-3])

HSP 1 Score: 83.5741 bits (205), Expect = 1.579e-17
Identity = 48/138 (34.78%), Postives = 75/138 (54.35%), Query Frame = 3 
Query:   90 LIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPT 485
            + E+AT   L   DW  N+  CD++ + E   K A+ AI+KK+ G+ N   V+ +L ++E+  KNCG   H  +A +DF++   +K +  + +P   V+ K L LIQ WA AFR       +   Y  LK +G  FP+
Sbjct:    1 ITERATDGALPGEDWTLNMEICDIVSETEDGPKDAIRAIRKKLSGNKNFREVMLTLTVLETCVKNCGHRFHTLVAQRDFVDGVLVKVVQPKNNPPALVQDKVLSLIQAWADAFRSSPDLTGVVHVYEELKKKGIEFPS 138
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Sea Lamprey
Match: tom1l2 (target of myb1 like 2 membrane trafficking protein [Source:ZFIN;Acc:ZDB-GENE-061013-3])

HSP 1 Score: 82.8037 bits (203), Expect = 4.031e-17
Identity = 48/136 (35.29%), Postives = 74/136 (54.41%), Query Frame = 3 
Query:   96 EKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPT 485
            E+AT   L   DW  N+  CD++ + E   K A+ AI+KK+ G+ N   V+ +L ++E+  KNCG   H  +A +DF++   +K +  + +P   V+ K L LIQ WA AFR       +   Y  LK +G  FP+
Sbjct:    1 ERATDGALPGEDWTLNMEICDIVSETEDGPKDAIRAIRKKLSGNKNFREVMLTLTVLETCVKNCGHRFHTLVAQRDFVDGVLVKVVQPKNNPPALVQDKVLSLIQAWADAFRSSPDLTGVVHVYEELKKKGIEFPS 136
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Sea Lamprey
Match: ankfy1 (ankyrin repeat and FYVE domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-041222-1])

HSP 1 Score: 77.0258 bits (188), Expect = 1.579e-14
Identity = 37/105 (35.24%), Postives = 50/105 (47.62%), Query Frame = 3 
Query:  411 RHQSKYGVIQS-TYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSG 722
            R  ++ G+  S   N    Q  T   L     M   E  P W D   CY C   F    RKHHCRHCG + C+ C++K   I K+ + K VRVC+ C++ +   G
Sbjct: 1064 RAGARLGLTNSQGVNIFNYQVATKQLLFRLLDMLSKE--PPWCDGSNCYECAAKFGVTTRKHHCRHCGRLLCNRCSAKEIPIIKFDLNKPVRVCDICFDVLTLGG 1166
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Sea Lamprey
Match: stam (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:ZFIN;Acc:ZDB-GENE-031118-123])

HSP 1 Score: 74.7146 bits (182), Expect = 2.464e-14
Identity = 42/131 (32.06%), Postives = 65/131 (49.62%), Query Frame = 3 
Query:   96 EKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPT 485
            EKATS L    DWA  L  CD I       K  + A  K++ +  PHV + +L L+ +   NCG   H E+ +++F N++  ++ +  P V  K   L+  WA  F++  +  +I +    LK QG  FP 
Sbjct:   12 EKATSELNTTEDWALILDVCDKIGHSPQGPKDCLRATMKRVNNKVPHVAMQALTLLGACVSNCGKIFHLEVCSREFANEVNNVLNKAHPKVGEKLKALMMEWAEEFKNDPQLSLIAAMIKNLKDQGVAFPA 142
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Sea Lamprey
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 67.0106 bits (162), Expect = 1.774e-11
Identity = 30/59 (50.85%), Postives = 39/59 (66.10%), Query Frame = 3 
Query:  537 DADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIK 713
            +   C  C   FS   RKHHCRHCGNIFC EC+++ S IP    +K VRVC++C+E +K
Sbjct: 1312 EVQNCMGCGKGFSVTVRKHHCRHCGNIFCGECSARNSMIPS--AKKPVRVCDTCFEELK 1368
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Yeast
Match: VPS27 (Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [Source:SGD;Acc:S000005289])

HSP 1 Score: 128.257 bits (321), Expect = 4.342e-31
Identity = 82/227 (36.12%), Postives = 120/227 (52.86%), Query Frame = 3 
Query:   81 FDKLIEKATSHLLL--ETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHT--NPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAH----AFRHQSKYGVIQSTYNFLKSQGCTFP---TLIESD-AMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGH 725
             D LIE+ATS  +   + D    L   D++R   V  K ++  IKK++ +T  NP+  + S  L     KN G+    EI +++FM+ M+ +I  +D     S EL++   +    AF++ S+   +   Y+ L S+G  FP   TL  S  AMF S+T  +W D+D C  C   FS L RKHHCR CG +FC E +S    +P  GI + VRVC+SC+E      H
Sbjct:    9 LDALIEQATSESIPNGDLDLPIALEISDVLRSRRVNPKDSMRCIKKRILNTADNPNTQLSSWKLTNICVKNGGTPFIKEICSREFMDTMEHVILREDSNEELS-ELVKTILYELYVAFKNDSQLNYVAKVYDKLISRGIKFPEKLTLSNSPTAMFDSKTPADWIDSDACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYDLKRH 234
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Yeast
Match: GGA1 (Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication [Source:SGD;Acc:S000002766])

HSP 1 Score: 67.3958 bits (163), Expect = 6.030e-12
Identity = 44/141 (31.21%), Postives = 72/141 (51.06%), Query Frame = 3 
Query:   93 IEKATSHLLLETDWAANLMACDMI--RQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKS-----LELIQVWAHAF-RHQS---KYGVIQSTYNFLKSQGCTFP 482
            I++A    L E D   NL   D I  +QG  T + AV AI+K + + +    +++L+L++ + KNCG +IH +I+ ++F+N +     E+ P+R        LE I+ W     +H S       I   +  LK +G TFP
Sbjct:   26 IQRACRSTLPEPDLGLNLDVADYINSKQG-ATPREAVLAIEKLVNNGDTQAAVFALSLLDVLVKNCGYSIHLQISRKEFLNDLVKRFPEQPPLRYSKVQQMILEAIEEWYQTICKHASYKDDLQYINDMHKLLKYKGYTFP 165
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Yeast
Match: GGA2 (Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication [Source:SGD;Acc:S000001150])

HSP 1 Score: 67.0106 bits (162), Expect = 8.310e-12
Identity = 47/154 (30.52%), Postives = 75/154 (48.70%), Query Frame = 3 
Query:   72 NPSFDKLIEKATSHLLLETDWAANLMACDMI--RQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLE-----LIQVWAHAFRHQSKY----GVIQSTYNFLKSQGCTFPTLIESD 500
            NP   K I++A    L E D A NL   D I  +QG    + A  A+ K + +   HV I++L+L++ + KNCG   H +I+ ++F+N++        P+R   ++      I+ W       S Y    G I+  +  LK +G  FP + ESD
Sbjct:   24 NPLLRK-IQRACRMSLAEPDLALNLDIADYINEKQG-AAPRDAAIALAKLINNRESHVAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPGHPPLRYSKIQRLILTAIEEWYQTICKHSSYKNDMGYIRDMHRLLKYKGYAFPKISESD 175
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Yeast
Match: FAB1 (1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis [Source:SGD;Acc:S000001915])

HSP 1 Score: 56.225 bits (134), Expect = 2.353e-8
Identity = 23/52 (44.23%), Postives = 31/52 (59.62%), Query Frame = 3 
Query:  549 CYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYE 704
            C+ C   F+  +RKHHCR CG IFC  CT       ++G   ++RVC +CYE
Sbjct:  246 CFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDG-DRFGCHAKMRVCYNCYE 296
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Yeast
Match: HSE1 (Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994])

HSP 1 Score: 54.299 bits (129), Expect = 5.608e-8
Identity = 27/85 (31.76%), Postives = 54/85 (63.53%), Query Frame = 3 
Query:   99 KATSHLLLETDWAANLMACDMIRQ-GEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIK 350
            KAT   L   +W   L  CD++++  E  G+  ++ I+K++   + +V++ +L+L  S+A+NCGS +  EI++++F + + ALI+
Sbjct:   14 KATDPKLRSDNWQYILDVCDLVKEDPEDNGQEVMSLIEKRLEQQDANVILRTLSLTVSLAENCGSRLRQEISSKNFTSLLYALIE 98
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Nematostella
Match: EDO44864 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUJ2])

HSP 1 Score: 271.166 bits (692), Expect = 6.053e-84
Identity = 119/220 (54.09%), Postives = 161/220 (73.18%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKE-KDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            M  FS + +F  L+E+ATS L LE DWA  L  CD +RQ +V+ K+AV+AIKKKM   NPHV  Y+L ++E+  KNCGS IHDEIAT+DFM++M+ LIK   DPV+ K+L LIQ W+HAFR++ KY ++Q T+N +K +GC FP   ESDAMF +++AP W + D C+ C++ F    R+HHCR+CG +FC +C+SK S IP++GIEKEVRVC+ CY  I
Sbjct:    1 MGVFSGSSTFTGLLERATSQLQLEPDWATILQICDSVRQQDVSPKFAVSAIKKKMFDRNPHVAKYALTVLEACMKNCGSIIHDEIATKDFMDEMRNLIKNGADPVKDKALGLIQTWSHAFRNEPKYKIVQDTFNLMKMEGCKFPAFNESDAMFSADSAPAWAEGDVCHMCRVKFGTFIRQHHCRNCGQVFCKKCSSKESIIPQFGIEKEVRVCDPCYLKI 220
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Nematostella
Match: EDO44865 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUJ3])

HSP 1 Score: 111.309 bits (277), Expect = 3.143e-25
Identity = 88/256 (34.38%), Postives = 138/256 (53.91%), Query Frame = 2 
Query: 2018 PANQIGFNGIYSSLDTSE--MDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESV---NHVQNSV------------------------------KNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDR 2680
            PA+Q  +N +  S    +  +DPELARYLNR+YWE++   TS       PSAP          Q NN  V   +H++N V                              + T   L   Q S   E  ++  +SS+E+ + RM     +G+ +A D+ VQ+LF T++AMHPQLL+ + +Q+ +   +E +Q++L  +++AR  L+  RE HREK R++E E   LR++Q+ QKLE+MRQ+K E+L YQ+++  +R
Sbjct:   26 PASQF-YNAVVESDGGGDQPVDPELARYLNRSYWEDRKGRTS-------PSAPE--------AQMNNSRVPYSSHIENKVTSKGKKKKKKDNFYKFTPQPQAIQEPEVNDQETNGDLETDQSS---ETLVNNFRSSVEMLMERMQDISGKGKHVAMDATVQSLFQTVSAMHPQLLRLVEQQEQETGKYEGIQERLGLVKEARATLEGAREAHREKLRQQELEQDMLRRMQIEQKLELMRQQKAEYLAYQQRIQAER 262
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Nematostella
Match: EDO42652 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0W4])

HSP 1 Score: 93.2041 bits (230), Expect = 1.714e-20
Identity = 56/150 (37.33%), Postives = 82/150 (54.67%), Query Frame = 3 
Query:   57 TFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEK-DP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFP 482
            + F  NP      + IE+AT   L   DW+ NL  CD+I + +   K A  AI+K++  + N   V+ +L ++ES  KNCG   H  +A ++F+++M  L+  K +P   V+ K L LIQ WA AFR+      I  TY  L+SQG  FP
Sbjct:    3 SLFGVNPFSTPVGQRIERATDGGLASEDWSLNLEICDIINETDEGPKDAAKAIRKRLTNNKNFKSVLLTLTVLESCIKNCGHRFHVLVAKKEFLDEMTKLLSPKLNPPQVVQEKILSLIQDWADAFRNSPDMSAILQTYEGLRSQGIEFP 152
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Nematostella
Match: EDO39875 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8S0])

HSP 1 Score: 75.485 bits (184), Expect = 8.798e-16
Identity = 30/60 (50.00%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:  531 WQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            W D D+CY C + FS   RKHHCRHCG + C +C+ K+  I KY + K VRVC+ C+E +
Sbjct:  109 WSDGDSCYECGMKFSIKHRKHHCRHCGRLLCAKCSCKQIPIIKYELAKPVRVCDVCFEML 168
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Nematostella
Match: EDO46357 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQF8])

HSP 1 Score: 79.7221 bits (195), Expect = 2.431e-15
Identity = 49/156 (31.41%), Postives = 78/156 (50.00%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIR------------QGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKA-LIKEKDP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTF 479
            M  FS +  +D+ +EKATS L    DW   +  CD I             +GE   K A+ +I K++ H NPH+ + +L L+ +   NCG   H EI ++DF+++ K+ L+    P V  K  ELI+ W + F+   +  +I      LK++G   
Sbjct:    1 MPLFSSSSPYDQEVEKATSELNTTEDWQIIMEICDKIPRSPNGLIFTREGKGEERPKDALRSIMKRVIHRNPHIAMQALTLLSACVNNCGKVFHLEICSRDFVSEAKSILLSRTHPKVMDKFKELIKEWVNMFKEDPQLSLISVMCEQLKTEGVDL 156
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Medaka
Match: hgs (hepatocyte growth factor-regulated tyrosine kinase substrate [Source:NCBI gene;Acc:101168120])

HSP 1 Score: 279.641 bits (714), Expect = 4.612e-81
Identity = 118/212 (55.66%), Postives = 160/212 (75.47%), Query Frame = 3 
Query:   78 SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDP-VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESI 710
            +F++L++KATS LLLETDW + L  CD+IRQG+   K A+ AIKKK+   NPHV +Y+L ++ES+ KNCG T+HDE+A++  M ++K L+K+ +P VR+K L LIQ WAHAFR++ KY V+Q TY  +K +G  FP   ESDAMF +E AP+W DA+ C+RC++ F  + RKHHCR CG IFC +C+SK S IPK+GIEKEVRVCE C+E +
Sbjct:    7 TFERLLDKATSQLLLETDWESILQICDLIRQGDAQAKNAIAAIKKKLNDKNPHVALYALEVLESVVKNCGQTVHDEVASKQTMEELKELLKQTEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQL 218

HSP 2 Score: 175.637 bits (444), Expect = 3.959e-45
Identity = 113/218 (51.83%), Postives = 149/218 (68.35%), Query Frame = 2 
Query: 2069 EMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESV-NHVQ-NSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRL 2716
            ++DPELARYLNR YWE K  +     K+  PSAP  P S    + A ++ V +HV    V   +      +     E+FL  L+ ++  F+NRM SN  RGRSI +DSAV +LF ++N MHPQLL  +N+ D++R Y+E LQDKL Q+RDAR AL+ALR+EHREK RR  E+A + RQIQ+ QKLEIMRQKKQE+L+ QRQLA+ R+Q+QE+E  MRL
Sbjct:  331 DVDPELARYLNRTYWEKKQEEAR---KSPTPSAPA-PVSLAEPLPAVSQPVESHVPVQPVSIIEQPYQNGESEENHEQFLKDLQYAVTTFLNRMKSNHMRGRSITNDSAVLSLFQSINNMHPQLLDILNQLDEKRLYYEGLQDKLAQVRDARAALNALRDEHREKLRRAAEDAERQRQIQLAQKLEIMRQKKQEYLEMQRQLAIQRLQEQEKERQMRL 544
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Medaka
Match: stam2 (signal transducing adaptor molecule 2 [Source:NCBI gene;Acc:101159231])

HSP 1 Score: 93.9745 bits (232), Expect = 1.248e-19
Identity = 51/145 (35.17%), Postives = 81/145 (55.86%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQV-WAHAFRHQSKYGVIQSTYNFLKSQGCTFPT 485
            M FF+ NP FD+ +EKAT+      DWA  L  CD I       K ++ +I K++ H  PHV + +LNL+ +   NCG   H EI ++DF +++++++    P   + L+ + V WA  F+   +  +I +T   LK +G TFPT
Sbjct:    1 MPFFAPNP-FDQDVEKATNENNTTDDWALILDICDKIGTTSNGAKDSLKSIMKRVNHKVPHVAMQALNLLGACVSNCGKIFHLEICSRDFASEVRSVLSRAHPKVCERLKALMVEWAEDFQKDPQLSLISATIKSLKEEGITFPT 144
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Medaka
Match: stam2 (signal transducing adaptor molecule 2 [Source:NCBI gene;Acc:101159231])

HSP 1 Score: 93.9745 bits (232), Expect = 1.450e-19
Identity = 51/145 (35.17%), Postives = 81/145 (55.86%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQV-WAHAFRHQSKYGVIQSTYNFLKSQGCTFPT 485
            M FF+ NP FD+ +EKAT+      DWA  L  CD I       K ++ +I K++ H  PHV + +LNL+ +   NCG   H EI ++DF +++++++    P   + L+ + V WA  F+   +  +I +T   LK +G TFPT
Sbjct:    1 MPFFAPNP-FDQDVEKATNENNTTDDWALILDICDKIGTTSNGAKDSLKSIMKRVNHKVPHVAMQALNLLGACVSNCGKIFHLEICSRDFASEVRSVLSRAHPKVCERLKALMVEWAEDFQKDPQLSLISATIKSLKEEGITFPT 144
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Medaka
Match: ENSORLT00000018311.2 (target of Myb protein 1 [Source:NCBI gene;Acc:101170496])

HSP 1 Score: 93.2041 bits (230), Expect = 2.247e-19
Identity = 56/166 (33.73%), Postives = 89/166 (53.61%), Query Frame = 3 
Query:   36 YYFSEIMTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKM-GHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAM 506
            +   E M F   NP      + IE+ATS  L   DW  NL  CD+I + +   K AV AIKK++ G+ N   ++ +L ++E+  KNCG   H  +ATQDF+    +++++ + +P   +  + L LIQ WA AFR       +   Y+ L+ +G  FP + + DA+
Sbjct:    2 FSLGETMDFLIGNPFSTPVGQRIERATSGSLQAEDWGLNLEICDIINETDEGPKDAVKAIKKRIVGNKNFREIMLALTVLETCVKNCGHRFHALVATQDFVEGVLVRSILPKYNPPTILHDRVLSLIQSWADAFRTNPSLSGVVYVYDDLRRRGLEFP-MTDLDAL 166
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Medaka
Match: tom1 (target of Myb protein 1 [Source:NCBI gene;Acc:101156253])

HSP 1 Score: 93.9745 bits (232), Expect = 2.408e-19
Identity = 59/165 (35.76%), Postives = 85/165 (51.52%), Query Frame = 3 
Query:   54 MTFFSKNP---SFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKK-MGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQ--MKALIKEKDP---VRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSET 521
            M FF  NP   +  + IE+ATS  L   DW  NL  CD I   E   K A+ AIKK+ +G+ N   V+ +L ++E+  KNCG+  H  + T+DF+    ++A+I   +P   V  + L +IQ WA AFR       + S Y  L+ +G  FP   +   M V  T
Sbjct:  132 MEFFLGNPFSTAVGQRIERATSSSLQSEDWELNLEICDTINSSEEGPKDAIRAIKKRIIGNKNFKEVMLTLTVLETCVKNCGNRFHILVTTRDFIEGVLVRAIIPSNNPPLIVHDRVLGIIQAWADAFRSSPDLTGVVSVYEDLRRKGLEFPVTPQEGYMPVQTT 296
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Planmine SMEST
Match: SMESG000066383.1 (SMESG000066383.1)

HSP 1 Score: 553.903 bits (1426), Expect = 0.000e+0
Identity = 255/256 (99.61%), Postives = 255/256 (99.61%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 821
            MTFFSKNPSFDKLIEKATSHLLLE DWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM
Sbjct:    1 MTFFSKNPSFDKLIEKATSHLLLEPDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 256

HSP 2 Score: 452.21 bits (1162), Expect = 9.258e-147
Identity = 245/246 (99.59%), Postives = 246/246 (100.00%), Query Frame = 2 
Query: 1982 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 2719
            GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHV+NSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA
Sbjct:  283 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVKNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 528
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Planmine SMEST
Match: SMESG000066383.1 (SMESG000066383.1)

HSP 1 Score: 551.206 bits (1419), Expect = 0.000e+0
Identity = 255/256 (99.61%), Postives = 255/256 (99.61%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 821
            MTFFSKNPSFDKLIEKATSHLLLE DWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM
Sbjct:    1 MTFFSKNPSFDKLIEKATSHLLLEPDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 256

HSP 2 Score: 452.595 bits (1163), Expect = 1.179e-144
Identity = 245/246 (99.59%), Postives = 246/246 (100.00%), Query Frame = 2 
Query: 1982 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 2719
            GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHV+NSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA
Sbjct:  283 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVKNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 528
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Planmine SMEST
Match: SMESG000066383.1 (SMESG000066383.1)

HSP 1 Score: 544.658 bits (1402), Expect = 0.000e+0
Identity = 255/268 (95.15%), Postives = 255/268 (95.15%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGS------------GHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 821
            MTFFSKNPSFDKLIEKATSHLLLE DWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGS            GHVQFNEDVIVRNFTPESKETTSDASRAQKEREM
Sbjct:    1 MTFFSKNPSFDKLIEKATSHLLLEPDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSDVRTGRVTNKKGGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 268

HSP 2 Score: 452.595 bits (1163), Expect = 8.894e-147
Identity = 245/246 (99.59%), Postives = 246/246 (100.00%), Query Frame = 2 
Query: 1982 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 2719
            GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHV+NSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA
Sbjct:  295 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVKNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 540
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Planmine SMEST
Match: SMESG000066383.1 (SMESG000066383.1)

HSP 1 Score: 541.576 bits (1394), Expect = 4.035e-178
Identity = 255/268 (95.15%), Postives = 255/268 (95.15%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGS------------GHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 821
            MTFFSKNPSFDKLIEKATSHLLLE DWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGS            GHVQFNEDVIVRNFTPESKETTSDASRAQKEREM
Sbjct:    1 MTFFSKNPSFDKLIEKATSHLLLEPDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSDVRTGRVTNKKGGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 268

HSP 2 Score: 452.595 bits (1163), Expect = 4.850e-144
Identity = 245/246 (99.59%), Postives = 246/246 (100.00%), Query Frame = 2 
Query: 1982 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 2719
            GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHV+NSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA
Sbjct:  295 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVKNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 540
[Close]
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Planmine SMEST
Match: SMESG000066383.1 (SMESG000066383.1)

HSP 1 Score: 538.88 bits (1387), Expect = 7.316e-177
Identity = 255/268 (95.15%), Postives = 255/268 (95.15%), Query Frame = 3 
Query:   54 MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGS------------GHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 821
            MTFFSKNPSFDKLIEKATSHLLLE DWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGS            GHVQFNEDVIVRNFTPESKETTSDASRAQKEREM
Sbjct:    1 MTFFSKNPSFDKLIEKATSHLLLEPDWAANLMACDMIRQGEVTGKYAVTAIKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKEKDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDAMFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNIPKYGIEKEVRVCESCYESIKGSDVRTGRVTNKKGGHVQFNEDVIVRNFTPESKETTSDASRAQKEREM 268

HSP 2 Score: 451.825 bits (1161), Expect = 2.051e-143
Identity = 245/246 (99.59%), Postives = 246/246 (100.00%), Query Frame = 2 
Query: 1982 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDXXXXXXXXXXXXXXXXXXXXXQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 2719
            GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHV+NSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA
Sbjct:  295 GKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENKANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVKNSVKNTKDSLNVSQISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAMHPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREEEEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLA 540
The following BLAST results are available for this feature:
BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HGS9.665e-8055.87hepatocyte growth factor-regulated tyrosine kinase... [more]
HGS1.146e-7853.08hepatocyte growth factor-regulated tyrosine kinase... [more]
HGS1.390e-3244.24hepatocyte growth factor-regulated tyrosine kinase... [more]
TOM11.183e-2036.18target of myb1 membrane trafficking protein [Sourc... [more]
TOM13.100e-1936.18target of myb1 membrane trafficking protein [Sourc... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hgrs-14.425e-6648.10Hepatocyte Growth factor-Regulated TK Substrate (H... [more]
hgrs-14.425e-6648.10Hepatocyte Growth factor-Regulated TK Substrate (H... [more]
C07A12.74.794e-1736.54pep chromosome:WBcel235:X:4517748:4521069:-1 gene:... [more]
C07A12.74.794e-1736.54pep chromosome:WBcel235:X:4517748:4521049:-1 gene:... [more]
C07A12.76.497e-1736.54pep chromosome:WBcel235:X:4517748:4521049:-1 gene:... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hrs1.076e-6750.45gene:FBgn0031450 transcript:FBtr0089750[more]
Hrs1.076e-6750.45gene:FBgn0031450 transcript:FBtr0089751[more]
Hrs1.250e-4047.66gene:FBgn0031450 transcript:FBtr0089749[more]
CG35297.605e-2239.42gene:FBgn0035995 transcript:FBtr0076461[more]
CG35298.009e-2239.42gene:FBgn0035995 transcript:FBtr0331582[more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hgs1.230e-8056.87hepatocyte growth factor-regulated tyrosine kinase... [more]
tom16.394e-1935.53target of myb1 membrane trafficking protein [Sourc... [more]
tom17.207e-1935.53target of myb1 membrane trafficking protein [Sourc... [more]
stam1.482e-1730.82signal transducing adaptor molecule (SH3 domain an... [more]
TOM1L21.538e-1633.75target of myb1 like 2 membrane trafficking protein... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ighx7.781e-8050.19immunoglobulin heavy chain precursor [Source:Xenba... [more]
ighx4.331e-7950.60immunoglobulin heavy chain precursor [Source:Xenba... [more]
ighx4.260e-7750.60immunoglobulin heavy chain precursor [Source:Xenba... [more]
ighx4.437e-7750.60immunoglobulin heavy chain precursor [Source:Xenba... [more]
ighx7.417e-7750.60immunoglobulin heavy chain precursor [Source:Xenba... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hgs6.389e-8049.03HGF-regulated tyrosine kinase substrate [Source:MG... [more]
Hgs6.446e-8049.03HGF-regulated tyrosine kinase substrate [Source:MG... [more]
Hgs5.752e-7953.08HGF-regulated tyrosine kinase substrate [Source:MG... [more]
Hgs1.697e-3342.31HGF-regulated tyrosine kinase substrate [Source:MG... [more]
Tom11.545e-1936.84target of myb1 trafficking protein [Source:MGI Sym... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q99LI8|HGS_MOUSE4.469e-7949.03Hepatocyte growth factor-regulated tyrosine kinase... [more]
sp|O14964|HGS_HUMAN4.641e-7955.87Hepatocyte growth factor-regulated tyrosine kinase... [more]
sp|Q9JJ50|HGS_RAT5.455e-7955.87Hepatocyte growth factor-regulated tyrosine kinase... [more]
sp|Q0V8S0|HGS_BOVIN6.460e-7955.40Hepatocyte growth factor-regulated tyrosine kinase... [more]
sp|Q960X8|HRS_DROME1.079e-6650.45Hepatocyte growth factor-regulated tyrosine kinase... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
C3Z6W84.810e-8558.49Uncharacterized protein (Fragment) OS=Branchiostom... [more]
A0A0M8ZXA53.856e-8354.98Hepatocyte growth factor-regulated tyrosine kinase... [more]
U6D5X67.681e-8149.03Uncharacterized protein (Fragment) OS=Neovison vis... [more]
A0A2J7Q3T01.259e-8049.61Hepatocyte growth factor-regulated tyrosine kinase... [more]
B4DFP52.023e-8055.87cDNA FLJ57484, highly similar to Hepatocyte growth... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hgs2.561e-4650.00hepatocyte growth factor-regulated tyrosine kinase... [more]
stam1.958e-1831.51signal transducing adaptor molecule [Source:NCBI g... [more]
tom1l21.118e-1734.87target of myb1 like 2 membrane trafficking protein... [more]
TOM1L21.129e-1735.63target of myb1 like 2 membrane trafficking protein... [more]
TOM1L21.196e-1735.63target of myb1 like 2 membrane trafficking protein... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tom1l21.579e-1734.78target of myb1 like 2 membrane trafficking protein... [more]
tom1l24.031e-1735.29target of myb1 like 2 membrane trafficking protein... [more]
ankfy11.579e-1435.24ankyrin repeat and FYVE domain containing 1 [Sourc... [more]
stam2.464e-1432.06signal transducing adaptor molecule (SH3 domain an... [more]
eea11.774e-1150.85early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
VPS274.342e-3136.12Endosomal protein that forms a complex with Hse1p;... [more]
GGA16.030e-1231.21Golgi-localized protein with homology to gamma-ada... [more]
GGA28.310e-1230.52Protein that regulates Arf1p, Arf2p to facilitate ... [more]
FAB12.353e-844.231-phosphatidylinositol-3-phosphate 5-kinase; vacuo... [more]
HSE15.608e-831.76Subunit of the endosomal Vps27p-Hse1p complex; com... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO448646.053e-8454.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO448653.143e-2534.38Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO426521.714e-2037.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO398758.798e-1650.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO463572.431e-1531.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hgs4.612e-8155.66hepatocyte growth factor-regulated tyrosine kinase... [more]
stam21.248e-1935.17signal transducing adaptor molecule 2 [Source:NCBI... [more]
stam21.450e-1935.17signal transducing adaptor molecule 2 [Source:NCBI... [more]
ENSORLT00000018311.22.247e-1933.73target of Myb protein 1 [Source:NCBI gene;Acc:1011... [more]
tom12.408e-1935.76target of Myb protein 1 [Source:NCBI gene;Acc:1011... [more]
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BLAST of Hepatocyte growth factor-regulated tyrosine kinase substrate vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000066383.19.258e-14799.61SMESG000066383.1[more]
SMESG000066383.11.179e-14499.61SMESG000066383.1[more]
SMESG000066383.18.894e-14795.15SMESG000066383.1[more]
SMESG000066383.14.035e-17895.15SMESG000066383.1[more]
SMESG000066383.17.316e-17795.15SMESG000066383.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034997 ID=SMED30034997|Name=Hepatocyte growth factor-regulated tyrosine kinase substrate|organism=Schmidtea mediterranea sexual|type=transcript|length=2809bp
TTCACAATCTTTATTAATTTGAATTTTATAAACAATATTATTTTTCAGAA
ATTATGACTTTTTTTAGTAAAAATCCTTCTTTTGATAAGTTAATAGAAAA
AGCTACCAGTCATTTACTGCTGGAAACTGACTGGGCAGCTAATTTAATGG
CCTGTGATATGATACGGCAAGGCGAAGTTACTGGAAAATATGCAGTTACT
GCAATTAAGAAGAAAATGGGTCACACCAACCCTCATGTCGTGATATACTC
TTTGAATCTTATTGAATCCATGGCTAAAAACTGTGGTTCAACAATTCATG
ATGAAATAGCAACTCAAGATTTTATGAATCAAATGAAAGCACTGATTAAA
GAAAAAGATCCTGTAAGATCAAAATCATTAGAATTGATTCAAGTTTGGGC
TCATGCTTTTCGACATCAATCAAAATATGGTGTTATTCAAAGTACCTATA
ACTTTTTGAAGAGTCAAGGTTGTACGTTTCCAACTTTAATAGAAAGTGAT
GCTATGTTTGTGTCCGAAACAGCTCCCGAATGGCAAGATGCTGATACTTG
TTATCGTTGTAAAATTGCATTTTCGGCTCTAAAACGAAAGCATCATTGTC
GACACTGTGGCAATATTTTCTGTGATGAATGTACCTCAAAAAGATCAAAT
ATTCCAAAGTATGGGATTGAAAAAGAGGTCAGAGTGTGTGAGTCATGCTA
TGAGTCCATTAAAGGCAGTGGACATGTGCAGTTTAACGAAGATGTTATTG
TGAGAAATTTTACCCCTGAGTCTAAGGAAACTACTTCTGATGCATCGAGA
GCACAAAAGGAACGTGAGATGGAATTACAAGAAAAAGAAGACTTAGAATT
GGCATTAGCCTTAAGCGCAAGTGAGGCAGAATCACAAGAGGTAAATCGGA
TAAGTAGAAATTTAGGATTTTTCTAATTTTAATATAAAATTAAAAGTTAA
ATATGAAAATATGAAGTTTAGATTTAAAAAAAAAATTAGATTAAAAAAAT
TCGATTAAAAAAATTAGATTAAAAAAAAATTAGATTCAAAAAAAAGAATA
AAAAAAATTATATTAAAAAAAATTAGATAAAAAAAAGATTAAAAAAAATT
AGATTGAAAATATTATTCCAAACCGTTTTAAAACATTCAGAAAAAACCAA
AAGGCTAAGTTTTATATATTATGTTTTGGGTAACGCCCAGTGACTGAACT
TTGATATATTGTCTTTGTTTTTTATTGTAATATTGCGCTTATATTTCATT
CGTTAGTTCATTGTATTGCTATTTAGTACACTCTGAATTTGCACAAAAGG
TTGTTTTTTAATGTTTCCTAATACCCAAATTTGGCCATTTTTCGTCCCCT
GCTCCAATAACTACATTGCTTATATCTTATAAGAAGTAATATTTTAATTT
TAAATAAAACGTGATAATCGGAATCGCAATAAAATTTGAATAAACGAATA
ATGAATTTTGCATTTTAGTTTAGTCTCAAGATTTGGCAGTGTTTCCAAAT
TCTAATATCGTTTCAATTTGGAAATTGTGCTGCAAAAATGGCCTTTTTTG
CCGCCAACTTAAACGAATTTTATACTTCTCATGTTTATTCATACCTTTTG
ACAGATTCTATTATCTTTTCTTCATTTTTGTCGTCGTTTATGCTGTAAAA
CTGTACAAATACAATCGGAACTGACATCTGTCTTATTAAAATCCAATTGG
CTCTGAATCTCACTTTTAATCATACTTTTCTTTTAGTGATCTATCAAATA
TTCCAATAGTATAGGGACAAGGAAATTACATATACGAACACGATTACATA
AAAATTACAATATAGGATAGTTTAATTTTGGAGGATTCGTAAGTGAGTTA
TTTTTCTATCATATACACATTTTGCTCTCTACTCTCTCTATATGTTCTTT
TCTAATTGTTCTTTTCTAATTTTTAAATTTATTTATTCCTTGATAAAATT
GGTCTGTATTGTTATGTAATAGATGAAAAAAGGTAAACCGATTGGGAAAA
GTGTTTCTCAACCTACTCCAGCAAATCAAATCGGCTTTAACGGCATATAT
TCAAGTCTTGATACAAGTGAAATGGACCCTGAATTAGCTAGATATTTAAA
TAGAAATTACTGGGAAAATAAAGCCAATGATACATCGAATAGTGTTAAGA
CTACACAACCATCTGCTCCAACTATGCCTAATTCACCTACTAGGATTATT
CAGGCAAATAACGAATCAGTAAATCACGTGCAAAATAGTGTTAAAAATAC
CAAAGATTCTTTGAATGTATCTCAAATTTCTTCTGAACAAGAGGAATTTC
TGTCAGCACTAAAAAGTAGTATTGAAATATTTGTTAATAGAATGCATAGC
AATAGACAAAGAGGCCGCAGTATTGCCAGTGATTCAGCCGTTCAAACTCT
ATTCTTAACACTTAATGCTATGCATCCGCAATTGCTTCAGTATATTAATG
AACAGGATGATCAAAGAAATTATTTTGAAGCTCTTCAAGATAAACTTACT
CAGTTGCGTGACGCCAGAGAAGCTCTTGATGCTTTGAGAGAAGAACACAG
AGAAAAAAAGAGACGTGAAGAAGAAGAAGCAGCAAAACTGAGACAAATTC
AAATGATGCAAAAACTTGAAATTATGCGTCAAAAGAAACAGGAATTTCTT
GATTATCAACGACAATTAGCGGTTGATAGAATGCAACAGCAAGAAAGAGA
AATGGCGATGAGATTGGCACAACAAAAGCAAATGATGCAAATGCGGCAAT
ATCAACAGCAATATCCATACTCTATGCAACAGCAGCAACAGCAACAACAG
CAACAACAG
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protein sequence of SMED30034997-orf-1

>SMED30034997-orf-1 ID=SMED30034997-orf-1|Name=SMED30034997-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=291bp
MTFFSKNPSFDKLIEKATSHLLLETDWAANLMACDMIRQGEVTGKYAVTA
IKKKMGHTNPHVVIYSLNLIESMAKNCGSTIHDEIATQDFMNQMKALIKE
KDPVRSKSLELIQVWAHAFRHQSKYGVIQSTYNFLKSQGCTFPTLIESDA
MFVSETAPEWQDADTCYRCKIAFSALKRKHHCRHCGNIFCDECTSKRSNI
PKYGIEKEVRVCESCYESIKGSGHVQFNEDVIVRNFTPESKETTSDASRA
QKEREMELQEKEDLELALALSASEAESQEVNRISRNLGFF*
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protein sequence of SMED30034997-orf-2

>SMED30034997-orf-2 ID=SMED30034997-orf-2|Name=SMED30034997-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=279bp
MKKGKPIGKSVSQPTPANQIGFNGIYSSLDTSEMDPELARYLNRNYWENK
ANDTSNSVKTTQPSAPTMPNSPTRIIQANNESVNHVQNSVKNTKDSLNVS
QISSEQEEFLSALKSSIEIFVNRMHSNRQRGRSIASDSAVQTLFLTLNAM
HPQLLQYINEQDDQRNYFEALQDKLTQLRDAREALDALREEHREKKRREE
EEAAKLRQIQMMQKLEIMRQKKQEFLDYQRQLAVDRMQQQEREMAMRLAQ
QKQMMQMRQYQQQYPYSMQQQQQQQQQQQ
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR000306Znf_FYVE
IPR002014VHS_dom
IPR008942ENTH_VHS
IPR013083Znf_RING/FYVE/PHD
IPR003903UIM_dom
IPR017455Znf_FYVE-rel
IPR011011Znf_FYVE_PHD
IPR024641HRS_helical
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0006886intracellular protein transport
GO:0016310phosphorylation
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 247..267
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 245..260
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 238..260
NoneNo IPR availablePANTHERPTHR46275FAMILY NOT NAMEDcoord: 7..282
NoneNo IPR availableCDDcd03569VHS_Hrscoord: 9..143
e-value: 2.86193E-75
score: 224.439
IPR000306FYVE zinc fingerSMARTSM00064fyve_4coord: 155..221
e-value: 9.1E-30
score: 114.9
IPR000306FYVE zinc fingerPFAMPF01363FYVEcoord: 161..219
e-value: 1.8E-18
score: 66.4
IPR002014VHS domainSMARTSM00288VHS_2coord: 10..139
e-value: 1.8E-49
score: 180.3
IPR002014VHS domainPFAMPF00790VHScoord: 9..139
e-value: 3.3E-41
score: 140.4
IPR002014VHS domainPROSITEPS50179VHScoord: 17..143
score: 36.73
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 155..223
e-value: 7.4E-27
score: 95.0
IPR008942ENTH/VHSGENE3DG3DSA:1.25.40.90coord: 4..154
e-value: 1.2E-49
score: 170.0
IPR008942ENTH/VHSSUPERFAMILYSSF48464ENTH/VHS domaincoord: 6..143
IPR017455Zinc finger, FYVE-relatedPROSITEPS50178ZF_FYVEcoord: 160..220
score: 14.212
IPR003903Ubiquitin interacting motifPROSITEPS50330UIMcoord: 259..278
score: 8.927
IPR011011Zinc finger, FYVE/PHD-typeSUPERFAMILYSSF57903FYVE/PHD zinc fingercoord: 160..221