Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30034929 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: KSR1 (kinase suppressor of ras 1 [Source:HGNC Symbol;Acc:HGNC:6465]) HSP 1 Score: 131.724 bits (330), Expect = 4.333e-31 Identity = 100/309 (32.36%), Postives = 157/309 (50.81%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMG-GKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNE---YIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + E + + + + Y APEI+ EM GKD ++ F + DVY+FG + YE+ +P KN+ E + I + G + + + + V I+ CW+ D RP FS + L K +R S PG+ + L
Sbjct: 318 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGV-VREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP----FSKAADVYAFGTVWYELQARDWP-LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSH--PGHFWKSAEL 612
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: KSR1 (kinase suppressor of ras 1 [Source:HGNC Symbol;Acc:HGNC:6465]) HSP 1 Score: 132.88 bits (333), Expect = 5.167e-31 Identity = 100/309 (32.36%), Postives = 157/309 (50.81%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMG-GKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNE---YIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + E + + + + Y APEI+ EM GKD ++ F + DVY+FG + YE+ +P KN+ E + I + G + + + + V I+ CW+ D RP FS + L K +R S PG+ + L
Sbjct: 468 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGV-VREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP----FSKAADVYAFGTVWYELQARDWP-LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSH--PGHFWKSAEL 762
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: KSR1 (kinase suppressor of ras 1 [Source:HGNC Symbol;Acc:HGNC:6465]) HSP 1 Score: 132.88 bits (333), Expect = 5.167e-31 Identity = 100/309 (32.36%), Postives = 157/309 (50.81%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMG-GKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNE---YIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + E + + + + Y APEI+ EM GKD ++ F + DVY+FG + YE+ +P KN+ E + I + G + + + + V I+ CW+ D RP FS + L K +R S PG+ + L
Sbjct: 468 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGV-VREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP----FSKAADVYAFGTVWYELQARDWP-LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSH--PGHFWKSAEL 762
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: KSR2 (kinase suppressor of ras 2 [Source:HGNC Symbol;Acc:HGNC:18610]) HSP 1 Score: 133.265 bits (334), Expect = 5.334e-31 Identity = 92/310 (29.68%), Postives = 152/310 (49.03%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLY-----EKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKD-----LPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + I + + APEI+ D LP F + +DV++ G + YE+H +P I + TG +P++ ++ + + +I+ CW+ + RP F+ + L K +R S PG+ + L
Sbjct: 658 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLP-------FSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSH--PGHFWKSAEL 950
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: KSR2 (kinase suppressor of ras 2 [Source:HGNC Symbol;Acc:HGNC:18610]) HSP 1 Score: 133.265 bits (334), Expect = 5.349e-31 Identity = 92/310 (29.68%), Postives = 152/310 (49.03%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLY-----EKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKD-----LPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + I + + APEI+ D LP F + +DV++ G + YE+H +P I + TG +P++ ++ + + +I+ CW+ + RP F+ + L K +R S PG+ + L
Sbjct: 629 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLP-------FSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSH--PGHFWKSAEL 921
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: ksr-1 (Kinase suppressor of Ras A [Source:UniProtKB/Swiss-Prot;Acc:G5EFD2]) HSP 1 Score: 104.375 bits (259), Expect = 1.644e-22 Identity = 81/272 (29.78%), Postives = 128/272 (47.06%), Query Frame = 2
Query: 1529 GNKRKVYKGHWHGDVSVFMFENLDH-----DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGP-SLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLV---W--YAAPEIL--------EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISREL 2287
G KV +G +GDV+V ++ ++H + F VS RH+NI LF+G + + MV S G SLY +H+ REK+ + + +QI QAV YLH TK I+ + L S+NI LE K + + D L + G+L W Y APE+ E D P F + +DVY+FG + +E+ G P ++ + G RP + ++ ++ +K ++ CW+ P RP +DI+ +L
Sbjct: 486 GRFGKVLRGFHYGDVAVKVY-TMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLH--TKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKS--GYLTSKFWTNYIAPELAMAMRTEYDEYECDDFP-------FSENSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKL 745
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: ksr-1 (Kinase suppressor of Ras A [Source:UniProtKB/Swiss-Prot;Acc:G5EFD2]) HSP 1 Score: 104.375 bits (259), Expect = 1.644e-22 Identity = 81/272 (29.78%), Postives = 128/272 (47.06%), Query Frame = 2
Query: 1529 GNKRKVYKGHWHGDVSVFMFENLDH-----DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGP-SLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLV---W--YAAPEIL--------EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISREL 2287
G KV +G +GDV+V ++ ++H + F VS RH+NI LF+G + + MV S G SLY +H+ REK+ + + +QI QAV YLH TK I+ + L S+NI LE K + + D L + G+L W Y APE+ E D P F + +DVY+FG + +E+ G P ++ + G RP + ++ ++ +K ++ CW+ P RP +DI+ +L
Sbjct: 486 GRFGKVLRGFHYGDVAVKVY-TMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLH--TKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKS--GYLTSKFWTNYIAPELAMAMRTEYDEYECDDFP-------FSENSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKL 745
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: ksr-2 (Kinase suppressor of Ras B [Source:UniProtKB/Swiss-Prot;Acc:G5EDA5]) HSP 1 Score: 95.1301 bits (235), Expect = 3.361e-20 Identity = 83/308 (26.95%), Postives = 144/308 (46.75%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH----DERSRFW--ENVSNLTMIRHENIVLFMGASIEPPH--FLMVTSACNGPSLYEKIHMS-REKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVC---IPGHLVWYAAPEI---LEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRAS-----ETVKNIIRECWSHDPLARPEFSDISRELM-----KRDTTRKRHSSS 2326
+ I D+ + + G VY G +HG+ +V F N+++ D R+ + E VS RH++I LF G +P + +VT+ +LY +IH E QS+ + QI QA+ YLH K I+ R L ++NI L+ + + D + + + ++ C IP H + Y +PEI L + + E F Q +DVYSFG + +E+ + R P+ + ++ + G++ ++ + A + ++ ECWS P RP F I + + K +KR S++
Sbjct: 148 DVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAV-RFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQHNTLYHRIHEQLSEDFDQSWTFQISLQICQAMSYLHKK--KILHRDLRTKNILLDNPNRVVVTDFALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRRMPTGCDSWDQKLYAKMCGQKAALQRLDAQLQKIDGKLHELLLECWSSQPEKRPSFQQIVKRITVQMPRKESNKQKRRSTA 452
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: ksr-2 (Kinase suppressor of Ras B [Source:UniProtKB/Swiss-Prot;Acc:G5EDA5]) HSP 1 Score: 95.1301 bits (235), Expect = 3.361e-20 Identity = 83/308 (26.95%), Postives = 144/308 (46.75%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH----DERSRFW--ENVSNLTMIRHENIVLFMGASIEPPH--FLMVTSACNGPSLYEKIHMS-REKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVC---IPGHLVWYAAPEI---LEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRAS-----ETVKNIIRECWSHDPLARPEFSDISRELM-----KRDTTRKRHSSS 2326
+ I D+ + + G VY G +HG+ +V F N+++ D R+ + E VS RH++I LF G +P + +VT+ +LY +IH E QS+ + QI QA+ YLH K I+ R L ++NI L+ + + D + + + ++ C IP H + Y +PEI L + + E F Q +DVYSFG + +E+ + R P+ + ++ + G++ ++ + A + ++ ECWS P RP F I + + K +KR S++
Sbjct: 148 DVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAV-RFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQHNTLYHRIHEQLSEDFDQSWTFQISLQICQAMSYLHKK--KILHRDLRTKNILLDNPNRVVVTDFALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRRMPTGCDSWDQKLYAKMCGQKAALQRLDAQLQKIDGKLHELLLECWSSQPEKRPSFQQIVKRITVQMPRKESNKQKRRSTA 452
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: ksr-2 (Kinase suppressor of Ras B [Source:UniProtKB/Swiss-Prot;Acc:G5EDA5]) HSP 1 Score: 95.1301 bits (235), Expect = 3.361e-20 Identity = 83/308 (26.95%), Postives = 144/308 (46.75%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH----DERSRFW--ENVSNLTMIRHENIVLFMGASIEPPH--FLMVTSACNGPSLYEKIHMS-REKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVC---IPGHLVWYAAPEI---LEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRAS-----ETVKNIIRECWSHDPLARPEFSDISRELM-----KRDTTRKRHSSS 2326
+ I D+ + + G VY G +HG+ +V F N+++ D R+ + E VS RH++I LF G +P + +VT+ +LY +IH E QS+ + QI QA+ YLH K I+ R L ++NI L+ + + D + + + ++ C IP H + Y +PEI L + + E F Q +DVYSFG + +E+ + R P+ + ++ + G++ ++ + A + ++ ECWS P RP F I + + K +KR S++
Sbjct: 148 DVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAV-RFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQHNTLYHRIHEQLSEDFDQSWTFQISLQICQAMSYLHKK--KILHRDLRTKNILLDNPNRVVVTDFALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRRMPTGCDSWDQKLYAKMCGQKAALQRLDAQLQKIDGKLHELLLECWSSQPEKRPSFQQIVKRITVQMPRKESNKQKRRSTA 452
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: ksr (gene:FBgn0015402 transcript:FBtr0078766) HSP 1 Score: 157.532 bits (397), Expect = 6.178e-39 Identity = 100/305 (32.79%), Postives = 160/305 (52.46%), Query Frame = 2
Query: 1466 INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF-ENLDHDER--SRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEK------YFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
I+ E++IP+GD+ L E + G V++ WHGDV+V + E+ DE F V+N RHEN+VLFMGA + PP+ +VTS C G +LY IH REK + + + +QIAQ +GYLHA+ II + L ++NI++E KV+++ L + L Y ++ + +P + + Y APE++ + PEK F +DVYSFG + YE+ G + I + G + + +++ VK+++ CW+++ RP+F+ + L R S S P NL
Sbjct: 667 ISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARE--IIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDM----GLGVPHNWLCYLAPELIR-------ALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNL 958
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: ksr (gene:FBgn0015402 transcript:FBtr0344273) HSP 1 Score: 157.532 bits (397), Expect = 6.178e-39 Identity = 100/305 (32.79%), Postives = 160/305 (52.46%), Query Frame = 2
Query: 1466 INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF-ENLDHDER--SRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEK------YFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
I+ E++IP+GD+ L E + G V++ WHGDV+V + E+ DE F V+N RHEN+VLFMGA + PP+ +VTS C G +LY IH REK + + + +QIAQ +GYLHA+ II + L ++NI++E KV+++ L + L Y ++ + +P + + Y APE++ + PEK F +DVYSFG + YE+ G + I + G + + +++ VK+++ CW+++ RP+F+ + L R S S P NL
Sbjct: 667 ISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARE--IIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDM----GLGVPHNWLCYLAPELIR-------ALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNL 958
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: ksr (gene:FBgn0015402 transcript:FBtr0344272) HSP 1 Score: 157.532 bits (397), Expect = 6.178e-39 Identity = 100/305 (32.79%), Postives = 160/305 (52.46%), Query Frame = 2
Query: 1466 INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF-ENLDHDER--SRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEK------YFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
I+ E++IP+GD+ L E + G V++ WHGDV+V + E+ DE F V+N RHEN+VLFMGA + PP+ +VTS C G +LY IH REK + + + +QIAQ +GYLHA+ II + L ++NI++E KV+++ L + L Y ++ + +P + + Y APE++ + PEK F +DVYSFG + YE+ G + I + G + + +++ VK+++ CW+++ RP+F+ + L R S S P NL
Sbjct: 667 ISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARE--IIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDM----GLGVPHNWLCYLAPELIR-------ALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNL 958
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: ksr (gene:FBgn0015402 transcript:FBtr0344274) HSP 1 Score: 157.532 bits (397), Expect = 6.178e-39 Identity = 100/305 (32.79%), Postives = 160/305 (52.46%), Query Frame = 2
Query: 1466 INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF-ENLDHDER--SRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEK------YFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
I+ E++IP+GD+ L E + G V++ WHGDV+V + E+ DE F V+N RHEN+VLFMGA + PP+ +VTS C G +LY IH REK + + + +QIAQ +GYLHA+ II + L ++NI++E KV+++ L + L Y ++ + +P + + Y APE++ + PEK F +DVYSFG + YE+ G + I + G + + +++ VK+++ CW+++ RP+F+ + L R S S P NL
Sbjct: 667 ISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARE--IIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDM----GLGVPHNWLCYLAPELIR-------ALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNL 958
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Raf (gene:FBgn0003079 transcript:FBtr0070401) HSP 1 Score: 108.997 bits (271), Expect = 6.062e-24 Identity = 91/300 (30.33%), Postives = 143/300 (47.67%), Query Frame = 2
Query: 1481 FNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSV--FMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYD-EIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP----STKNEVNEYIIETCTGKRPDIKEMR--ASETVKNIIRECWSHDPLARPEFSDISREL--MKRDTTRKRHSSSVPGNLHQ 2347
+NI +I +G + SG+ VY+ HWHG V+V + + F V+ L RH NI+LFMG + P +VT C G SLY+ +H+S K + + + + RQ+AQ + YLHAK II R L S NI+L + + + D P + + APE++ M ++ P + +DVY+FG++ YE+ P S K+++ + RPD+ ++R A + +K + +C + P RP F + L M R T K H S+ NL Q
Sbjct: 422 WNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGC-VSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQ-----ELNPYSF---QSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLL--RPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLR-TLPKIHRSASEPNLTQ 707
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: ksr1a (kinase suppressor of ras 1a [Source:ZFIN;Acc:ZDB-GENE-091113-34]) HSP 1 Score: 142.895 bits (359), Expect = 4.116e-34 Identity = 94/303 (31.02%), Postives = 157/303 (51.82%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEP-KVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + LGE + G +V++G WHG+V++ + E + D F + V N RHEN+VLFMGA + PPH ++TS C G +LY + ++ + + + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + E + + +P + Y APEI+ +M + +P F DVY+FG + YE+ +P T V I + +G+ R + E+ + V I+ CWS+D RP F+ ++ L K +R S PG+ + L
Sbjct: 731 EWDIPFEQLDLGELIGKGRWGRVHRGRWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMAPPHLAIITSFCKGRTLYSVVRDTKNTLDINKTRQIAQEIVKGMGYLHAKG--IVHKDLKSKNVFHDTNKVVITDFGLFGISGV-VQEGRRENELKLPHGWICYLAPEIVRKMSPGNNEDRLP---FSNAADVYAFGTIWYELQARDWPITSQPVEATIWQVGSGEGIRRVLAEINLGKEVTEILSACWSYDSRNRPAFTHLADMLEKLPKLNRRLSH--PGHFWKSAEL 1025
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: ksr1a (kinase suppressor of ras 1a [Source:ZFIN;Acc:ZDB-GENE-091113-34]) HSP 1 Score: 142.124 bits (357), Expect = 4.268e-34 Identity = 93/297 (31.31%), Postives = 155/297 (52.19%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEP-KVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + LGE + G +V++G WHG+V++ + E + D F + V N RHEN+VLFMGA + PPH ++TS C G +LY + ++ + + + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + E + + +P + Y APEI+ +M + +P F DVY+FG + YE+ +P T V I + +G+ R + E+ + V I+ CWS+D RP F+ ++ L K +R S PG+
Sbjct: 503 EWDIPFEQLDLGELIGKGRWGRVHRGRWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMAPPHLAIITSFCKGRTLYSVVRDTKNTLDINKTRQIAQEIVKGMGYLHAKG--IVHKDLKSKNVFHDTNKVVITDFGLFGISGV-VQEGRRENELKLPHGWICYLAPEIVRKMSPGNNEDRLP---FSNAADVYAFGTIWYELQARDWPITSQPVEATIWQVGSGEGIRRVLAEINLGKEVTEILSACWSYDSRNRPAFTHLADMLEKLPKLNRRLSH--PGHF 791
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: ksr2 (kinase suppressor of ras 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8047]) HSP 1 Score: 135.576 bits (340), Expect = 1.560e-32 Identity = 86/294 (29.25%), Postives = 155/294 (52.72%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-----EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYII-ETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSS 2323
E++IP + +GE + G +VY G WHG+V++ + E + ++ F V RHEN+VLFMGA + PPH ++TS C G +LY + ++ + + + +++ + +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APE++ E LP F + +DV++FG + YE+H +P KN+ E II + +G +P + ++ + + +I+ CW+++ RP FS + EL+++ R R S
Sbjct: 320 EWDIPMEQVEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRNTRHENVVLFMGACMRPPHLAIITSLCKGRTLYSVVRDAKVVLDVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRRKDKLRIPSGWLCHLAPELIRQLSPETAENQLP-------FSKQSDVFAFGTIWYELHAREWP-FKNQPAEVIIWQVGSGMKPILTQIGMGKEISDILLFCWAYEQEERPSFSKL-MELLEKLPKRNRRLS 602
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: ksr2 (kinase suppressor of ras 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8047]) HSP 1 Score: 135.961 bits (341), Expect = 4.494e-32 Identity = 91/295 (30.85%), Postives = 155/295 (52.54%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQ----AVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-----EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYII-ETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKR 2314
E++IP + +GE + G +VY G WHG+V++ + E + ++ F V RHEN+VLFMGA + PPH ++TS C G +LY + ++ + V+ RQIAQ +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APE++ E LP F + +DV++FG + YE+H +P KN+ E II + +G +P + ++ + + +I+ CW+++ RP FS + EL+++ R R
Sbjct: 667 EWDIPMEQVEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRNTRHENVVLFMGACMRPPHLAIITSLCKGRTLYSVVRDAKVVL----DVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRRKDKLRIPSGWLCHLAPELIRQLSPETAENQLP-------FSKQSDVFAFGTIWYELHAREWP-FKNQPAEVIIWQVGSGMKPILTQIGMGKEISDILLFCWAYEQEERPSFSKL-MELLEKLPKRNR 946
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: ksr2 (kinase suppressor of ras 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8047]) HSP 1 Score: 135.961 bits (341), Expect = 4.708e-32 Identity = 91/295 (30.85%), Postives = 155/295 (52.54%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQ----AVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-----EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYII-ETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKR 2314
E++IP + +GE + G +VY G WHG+V++ + E + ++ F V RHEN+VLFMGA + PPH ++TS C G +LY + ++ + V+ RQIAQ +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APE++ E LP F + +DV++FG + YE+H +P KN+ E II + +G +P + ++ + + +I+ CW+++ RP FS + EL+++ R R
Sbjct: 667 EWDIPMEQVEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRNTRHENVVLFMGACMRPPHLAIITSLCKGRTLYSVVRDAKVVL----DVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRRKDKLRIPSGWLCHLAPELIRQLSPETAENQLP-------FSKQSDVFAFGTIWYELHAREWP-FKNQPAEVIIWQVGSGMKPILTQIGMGKEISDILLFCWAYEQEERPSFSKL-MELLEKLPKRNR 946
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ksr1 (kinase suppressor of ras 1 [Source:NCBI gene;Acc:100494230]) HSP 1 Score: 135.961 bits (341), Expect = 6.199e-32 Identity = 96/301 (31.89%), Postives = 149/301 (49.50%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYI--IETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF I LGE + G KV++G WHG+V++ + E + D F + V N RHEN+VLFMGA + PPH ++TS C G +LY + + S ++ RQIAQ + GYLHAK I+ + L S+N++ E KVV++ L S + E + + + + Y APEI+ EM +P F + D+Y+FG + YE+ +P + I I + G + + + + V I+ CW+ D RP F+ + L K +R S PG+
Sbjct: 565 EWDIPFEQIELGELIGQGRWGKVFRGKWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMHPPHLAIITSFCKGRTLYSFVR----DPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYENGKVVITDFGLFGISGV-VQEGRRENELKLSHDWLCYLAPEIVREMTPGKGEDTLP---FSKAADIYAFGTIWYELQARDWPLKRQAAEALIWQIGSGEGMKQVLSTISLGKEVTEILAACWAFDVNERPSFTLLMDMLEKLPKLNRRLSH--PGHF 853
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: csnk1e (casein kinase 1 epsilon [Source:Xenbase;Acc:XB-GENE-481480]) HSP 1 Score: 133.265 bits (334), Expect = 1.075e-31 Identity = 90/300 (30.00%), Postives = 153/300 (51.00%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLY-----EKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + +GE + G VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + IP + + APEI+ D + +P F + +DV++ G + YE+H +P I + +G +P++ ++ + + +I+ CW + RP F+ + E++++ R R S PG+
Sbjct: 289 EWDIPFEQLEIGEMIGKGRFGLVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIPNGWLCHLAPEIICQLSPDTEEDKLP---FSKHSDVFALGTIWYELHAREWPFKSQPAEAIIWQVGSGMKPNLAQIGMGKEISDILMFCWVFEQEERPTFTKLM-EMLEKLPKRNRRLSH-PGHF 575
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: csnk1e (casein kinase 1 epsilon [Source:Xenbase;Acc:XB-GENE-481480]) HSP 1 Score: 134.035 bits (336), Expect = 2.555e-31 Identity = 91/306 (29.74%), Postives = 155/306 (50.65%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYE-----KIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + IP + + APEI+ D + +P F + +DV++ G + YE+H +P I + +G +P++ ++ + + +I+ CW + RP F+ + E++++ R R S PG+ + L
Sbjct: 664 EWDIPFEQLEIGEMIGKGRFGLVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIPNGWLCHLAPEIICQLSPDTEEDKLP---FSKHSDVFALGTIWYELHAREWPFKSQPAEAIIWQVGSGMKPNLAQIGMGKEISDILMFCWVFEQEERPTFTKL-MEMLEKLPKRNRRLSH-PGHFWKSAEL 956
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: csnk1e (casein kinase 1 epsilon [Source:Xenbase;Acc:XB-GENE-481480]) HSP 1 Score: 134.035 bits (336), Expect = 2.555e-31 Identity = 91/306 (29.74%), Postives = 155/306 (50.65%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYE-----KIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + IP + + APEI+ D + +P F + +DV++ G + YE+H +P I + +G +P++ ++ + + +I+ CW + RP F+ + E++++ R R S PG+ + L
Sbjct: 664 EWDIPFEQLEIGEMIGKGRFGLVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIPNGWLCHLAPEIICQLSPDTEEDKLP---FSKHSDVFALGTIWYELHAREWPFKSQPAEAIIWQVGSGMKPNLAQIGMGKEISDILMFCWVFEQEERPTFTKL-MEMLEKLPKRNRRLSH-PGHFWKSAEL 956
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: csnk1e (casein kinase 1 epsilon [Source:Xenbase;Acc:XB-GENE-481480]) HSP 1 Score: 133.265 bits (334), Expect = 3.930e-31 Identity = 90/300 (30.00%), Postives = 153/300 (51.00%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLY-----EKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + +GE + G VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + IP + + APEI+ D + +P F + +DV++ G + YE+H +P I + +G +P++ ++ + + +I+ CW + RP F+ + E++++ R R S PG+
Sbjct: 597 EWDIPFEQLEIGEMIGKGRFGLVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIPNGWLCHLAPEIICQLSPDTEEDKLP---FSKHSDVFALGTIWYELHAREWPFKSQPAEAIIWQVGSGMKPNLAQIGMGKEISDILMFCWVFEQEERPTFTKL-MEMLEKLPKRNRRLSH-PGHF 883
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Ksr2 (kinase suppressor of ras 2 [Source:MGI Symbol;Acc:MGI:3610315]) HSP 1 Score: 134.42 bits (337), Expect = 1.547e-31 Identity = 94/311 (30.23%), Postives = 153/311 (49.20%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLY-----EKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSH-LDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKD-----LPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S L D D + I + + APEI+ D LP F + +DV++ G + YE+H +P I + TG +P++ ++ + + +I+ CW+ + RP F+ + L K +R S PG+ + L
Sbjct: 659 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRD--DKLRIQNGWLCHLAPEIIRQLSPDTEEDKLP-------FSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSH--PGHFWKSAEL 951
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Ksr1 (kinase suppressor of ras 1 [Source:MGI Symbol;Acc:MGI:105051]) HSP 1 Score: 131.724 bits (330), Expect = 1.057e-30 Identity = 88/278 (31.65%), Postives = 143/278 (51.44%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILE--MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFS 2269
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + +E + + + + Y APEI+ + G+D ++ F + DVY+FG + YE+ +P I + +G+ R + + + V I+ CW+ D RP FS
Sbjct: 555 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREERRE-NQLKLSHDWLCYLAPEIVREMIPGRDEDQL----PFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFS 821
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Ksr1 (kinase suppressor of ras 1 [Source:MGI Symbol;Acc:MGI:105051]) HSP 1 Score: 130.954 bits (328), Expect = 1.470e-30 Identity = 88/278 (31.65%), Postives = 143/278 (51.44%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILE--MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFS 2269
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + +E + + + + Y APEI+ + G+D ++ F + DVY+FG + YE+ +P I + +G+ R + + + V I+ CW+ D RP FS
Sbjct: 473 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREERRE-NQLKLSHDWLCYLAPEIVREMIPGRDEDQLP----FSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFS 739
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Braf (Braf transforming gene [Source:MGI Symbol;Acc:MGI:88190]) HSP 1 Score: 126.716 bits (317), Expect = 2.571e-29 Identity = 97/295 (32.88%), Postives = 147/295 (49.83%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENL--DHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLD--CSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP-STKNEVNEYIIETCTGK-RPDIKEMRAS--ETVKNIIRECWSHDPLARPEFSDI--SRELMKRDTTRKRHSSSVP 2332
++ IP G I +G+ + SG+ VYKG WHGDV+V M + F V L RH NI+LFMG S +P +VT C G SLY +H+ K + + RQ AQ + YLHAK+ II R L S NI+L + + + D + + + + G ++W APE++ M K+ Y Q +DVY+FG++ YE+ G+ P S N ++ I G PD+ ++R++ + +K ++ EC RP F I S EL+ R + S+S P
Sbjct: 433 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDKN-------PYSFQ-SDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEP 715
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Braf (Braf transforming gene [Source:MGI Symbol;Acc:MGI:88190]) HSP 1 Score: 126.331 bits (316), Expect = 4.657e-29 Identity = 97/295 (32.88%), Postives = 147/295 (49.83%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENL--DHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLD--CSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP-STKNEVNEYIIETCTGK-RPDIKEMRAS--ETVKNIIRECWSHDPLARPEFSDI--SRELMKRDTTRKRHSSSVP 2332
++ IP G I +G+ + SG+ VYKG WHGDV+V M + F V L RH NI+LFMG S +P +VT C G SLY +H+ K + + RQ AQ + YLHAK+ II R L S NI+L + + + D + + + + G ++W APE++ M K+ Y Q +DVY+FG++ YE+ G+ P S N ++ I G PD+ ++R++ + +K ++ EC RP F I S EL+ R + S+S P
Sbjct: 486 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDKN-------PYSFQ-SDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEP 768
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q3UVC0|KSR2_MOUSE (Kinase suppressor of Ras 2 OS=Mus musculus OX=10090 GN=Ksr2 PE=1 SV=2) HSP 1 Score: 133.65 bits (335), Expect = 2.058e-30 Identity = 91/294 (30.95%), Postives = 149/294 (50.68%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYE-----KIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSH-LDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKD-----LPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFS---DISRELMKRD 2299
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S L D D + I + + APEI+ D LP F + +DV++ G + YE+H +P I + TG +P++ ++ + + +I+ CW+ + RP F+ D+ +L KR+
Sbjct: 668 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRD--DKLRIQNGWLCHLAPEIIRQLSPDTEEDKLP-------FSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRN 945
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P10533|RMIL_AVII1 (Serine/threonine-protein kinase-transforming protein Rmil OS=Avian retrovirus IC10 OX=11874 GN=V-RMIL PE=3 SV=1) HSP 1 Score: 127.487 bits (319), Expect = 2.314e-30 Identity = 97/295 (32.88%), Postives = 147/295 (49.83%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENL--DHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLD--CSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP-STKNEVNEYIIETCTGK-RPDIKEMRAS--ETVKNIIRECWSHDPLARPEFSDI--SRELMKRDTTRKRHSSSVP 2332
++ IP G I +G+ + SG+ VYKG WHGDV+V M + F V L RH NI+LFMG S +P +VT C G SLY +H+ K + + RQ AQ + YLHAK+ II R L S NI+L + + + D + + + + G ++W APE++ M K+ Y Q +DVY+FG++ YE+ G+ P S N ++ I G PD+ ++R++ + +K ++ EC RP F I S EL+ R + S+S P
Sbjct: 59 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDKN-------PYSFQ-SDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEP 341
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6VAB6|KSR2_HUMAN (Kinase suppressor of Ras 2 OS=Homo sapiens OX=9606 GN=KSR2 PE=1 SV=2) HSP 1 Score: 133.265 bits (334), Expect = 2.561e-30 Identity = 92/310 (29.68%), Postives = 152/310 (49.03%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLY-----EKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKD-----LPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY KI + K RQ + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + D + I + + APEI+ D LP F + +DV++ G + YE+H +P I + TG +P++ ++ + + +I+ CW+ + RP F+ + L K +R S PG+ + L
Sbjct: 658 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ-----IAQEIVKGMGYLHAKG--ILHKDLKSKNVFYDNGKVVITDFGLFSISGV-LQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLP-------FSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSH--PGHFWKSAEL 950
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8IVT5|KSR1_HUMAN (Kinase suppressor of Ras 1 OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=3) HSP 1 Score: 132.109 bits (331), Expect = 6.223e-30 Identity = 99/303 (32.67%), Postives = 155/303 (51.16%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMG-GKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNE---YIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + E + + + + Y APEI+ EM GKD ++ F + DVY+FG + YE+ +P KN+ E + I + G + + + + V I+ CW+ D RP FS + L K +R S PG+
Sbjct: 605 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGV-VREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQL----PFSKAADVYAFGTVWYELQARDWP-LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSH--PGHF 893
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q61097|KSR1_MOUSE (Kinase suppressor of Ras 1 OS=Mus musculus OX=10090 GN=Ksr1 PE=1 SV=1) HSP 1 Score: 131.724 bits (330), Expect = 7.397e-30 Identity = 88/278 (31.65%), Postives = 143/278 (51.44%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAV----GYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILE--MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFS 2269
E++IPF + LGE + G +V++G WHG+V++ + E H D F + V N RHEN+VLFMGA + PPH ++TS C G +L+ + + S ++ RQIAQ + GYLHAK I+ + L S+N++ + KVV++ L S + +E + + + + Y APEI+ + G+D ++ F + DVY+FG + YE+ +P I + +G+ R + + + V I+ CW+ D RP FS
Sbjct: 555 EWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFV----RDPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREERRE-NQLKLSHDWLCYLAPEIVREMIPGRDEDQL----PFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFS 821
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267H2G7 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004540g2 PE=4 SV=1) HSP 1 Score: 334.724 bits (857), Expect = 1.189e-99 Identity = 168/394 (42.64%), Postives = 253/394 (64.21%), Query Frame = 2
Query: 1211 TELDYDRLNRRNPRVFGNQALS----HACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYI---DNDLMSNCDEDFILERVDKC------INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPP--HFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQ 2347
++DYD L RRNPR N+ + + L+P P KSKSL SQ +R + LLCS+WPPSGRR+ + D +++ + +++ V + + +EFNIP DI EC+ G +RKVY+GHWHG+V++ +E+LD +ERS+FWE ++ L++IRHENI LFMG S++PP F +VT G +L+E +H+ +EK+ S ++S++R +AQA GYLHAK+ I++RR NS N++LEP+ LSL D S + +E D + +P LVWY PEIL + + +P+ F TD+++F ++ +E+ GRYP K + Y+ C G+R + ++RASE++K++I +CWSHDPL RPEF I+ L R++T RHSSS P NLH+
Sbjct: 176 VQVDYDLLQRRNPRHISNRLRAAPKQQSTLVPP---PAKSKSLQSQTARQQKDLLCSTWPPSGRRLHFALEEDEYMLTGVNCFHVIDSVMRNSRGSFEVKEFEFNIPHEDIEFRECVLRGRRRKVYRGHWHGEVTIHAYESLDSEERSKFWEEIAKLSLIRHENIFLFMGVSMDPPTSRFAVVTCLRKGVTLHETVHVRKEKLGASRRLSIIRDLAQAAGYLHAKS--IVIRRFNSSNVFLEPRAKLSLQDYSVITEEEEDRPGYLIVPESLVWYTPPEILALLTRKT-TFVPDSAFTVATDIFAFSIIMFEVCCGRYPFGKCDRLRYMEHICRGERDPMHDLRASESIKSLITDCWSHDPLYRPEFGQINLALNNRESTHLRHSSSEPENLHR 563
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267EPC2 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004540g1 PE=4 SV=1) HSP 1 Score: 337.806 bits (865), Expect = 1.302e-98 Identity = 171/395 (43.29%), Postives = 254/395 (64.30%), Query Frame = 2
Query: 1211 TELDYDRLNRRNPRVFGNQALS----HACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYI---DNDLMSNCDEDFILERVDKC------INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPP--HFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILE-MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQ 2347
++DYD L RRNPR N+ + + L+P P KSKSL SQ +R + LLCS+WPPSGRR+ + D +++ + +++ V + + +EFNIP DI EC+ G +RKVY+GHWHG+V++ +E+LD +ERS+FWE ++ L++IRHENI LFMG S++PP F +VT G +L+E +H+ +EK+ S ++S++R +AQA GYLHAK+ I++RR NS N++LEP+ LSL D S + +E D + +P LVWY PEIL + GK +P+ F TD+++F ++ +E+ GRYP K + Y+ C G+R + ++RASE++K++I +CWSHDPL RPEFS I+ L R+ T RHSSS P NLH+
Sbjct: 368 VQVDYDLLQRRNPRHISNRLRAAPEQQSTLVPP---PAKSKSLQSQTARQQKDLLCSTWPPSGRRLHFALEEDEYMLTGVNCFHVIDSVMRNSRGSFEVKEFEFNIPHEDIEFRECVLRGRRRKVYRGHWHGEVTIHAYESLDSEERSKFWEEIAKLSLIRHENIFLFMGVSMDPPTSRFAVVTCLRKGVTLHETVHVRKEKLGASRRLSIIRDLAQAAGYLHAKS--IVIRRFNSSNVFLEPRAKLSLQDYSVITEEEEDRPGYLIVPESLVWYTPPEILALLTGKT--TFVPDSAFTVATDIFAFSIIMFEVCCGRYPFGKCDRLRYMEHICRGERDPMHDLRASESIKSLITDCWSHDPLYRPEFSQINLALNNREATHLRHSSSEPENLHR 755
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267GVR8 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig007280g1 PE=4 SV=1) HSP 1 Score: 326.25 bits (835), Expect = 3.906e-94 Identity = 169/393 (43.00%), Postives = 239/393 (60.81%), Query Frame = 2
Query: 1211 TELDYDRLNRRNPRVFGNQALSHACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYI--DNDLMSNCDEDFILERVDKC---------INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPP--HFLMVTSACNGPSLYEKIHMS-REKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQ 2347
+LDYD L RRNPR + L A + S ++ S Q R + LLCS+WPPSG R+ + + + S + VD I +EFNIP+ I +C+ G +RKV++G WHGDV++ +ENLD ERS+FWE V+ L++IRHENI LFMGAS++PP F +VT G SLY+++H+ REK+ + K+S++R +AQA GYLHAK I++RR NS N++LEP+ LSL D S + +E D + +P LVWY PEIL D IP+ F +DV++F ++ YE+ GRYP K + +Y+ C G+R ++++R S+ +KN+I ECWSHDPL RPEFS I+ L R+T+ HSSS P NLH+
Sbjct: 397 VQLDYDLLQRRNPRQAARRMLDAATTARSWSLQSQAGSGGGQ-ERKGQLLLCSTWPPSGWRLAALSSEEEDCSTGGGAACFQVVDSVVQNSRGSFEIKEFEFNIPYDGIVFQDCLAKGRRRKVFRGQWHGDVTIHTYENLDCKERSKFWEEVAKLSLIRHENIFLFMGASMDPPTSRFAVVTCQRKGQSLYDRVHLHPREKLGSAGKLSIIRDLAQAAGYLHAKG--ILIRRFNSHNVFLEPRAKLSLQDYSVIAEEEEDRPGYLVVPASLVWYTPPEILTQLA-DKTSSIPDSAFTTASDVFAFSVIMYEVCAGRYPYAKCDRRQYMENVCQGRRDTVQDIRVSDIIKNLITECWSHDPLYRPEFSQINAALHNRETSHLWHSSSEPENLHR 785
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267G968 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig007280g2 PE=4 SV=1) HSP 1 Score: 325.865 bits (834), Expect = 6.993e-94 Identity = 168/393 (42.75%), Postives = 238/393 (60.56%), Query Frame = 2
Query: 1211 TELDYDRLNRRNPRVFGNQALSHACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYI--DNDLMSNCDEDFILERVDKC---------INRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPP--HFLMVTSACNGPSLYEKIHMS-REKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQ 2347
+ DYD L RRNPR + L A + S ++ S Q R + LLCS+WPPSG R+ + + + S + VD I +EFNIP+ I +C+ G +RKV++G WHGDV++ +ENLD ERS+FWE V+ L++IRHENI LFMGAS++PP F +VT G SLY+++H+ REK+ + K+S++R +AQA GYLHAK I++RR NS N++LEP+ LSL D S + +E D + +P LVWY PEIL D IP+ F +DV++F ++ YE+ GRYP K + +Y+ C G+R ++++R S+ +KN+I ECWSHDPL RPEFS I+ L R+T+ HSSS P NLH+
Sbjct: 397 VQFDYDLLQRRNPRQAARRMLDAATTARSWSLQSQAGSGGGQ-ERKGQLLLCSTWPPSGWRLAALSSEEEDCSTGGGAACFQVVDSVVQNSRGSFEIKEFEFNIPYDGIVFQDCLAKGRRRKVFRGQWHGDVTIHTYENLDCKERSKFWEEVAKLSLIRHENIFLFMGASMDPPTSRFAVVTCQRKGQSLYDRVHLHPREKLGSASKLSIIRDLAQAAGYLHAKG--ILIRRFNSHNVFLEPRAKLSLQDYSVIAEEEEDRPGYLVVPASLVWYTPPEILTQLA-DKTSSIPDSAFTTASDVFAFSVIMYEVCAGRYPYAKCDRRQYMENVCQGRRDTVQDIRVSDIIKNLITECWSHDPLYRPEFSQINAALHNRETSHLWHSSSEPENLHR 785
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: V4AN96 (Protein kinase domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_228139 PE=4 SV=1) HSP 1 Score: 242.662 bits (618), Expect = 1.472e-65 Identity = 137/359 (38.16%), Postives = 203/359 (56.55%), Query Frame = 2
Query: 1286 LLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYIDN---DLMSNCDEDFILERVDKCINRYE-FNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKII-PEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQ 2347
L T+SCPPK + S L +WP GR+I D+ +L+S E FI + + + E F+IP+ + + EC+K G + K+Y+G WHGDV+V +F++ D D FW+N++ L IRHENI+LFM A + P +VTS G SLYE IH+ EK+ KV +LRQ+A +GYLHAK I ++ LNS N++L PKV LS +D + + D IP H + Y APE+L P+++ + + TD+++FG + YE+ GRYP I + C G+R + ++R + +K +I CW +P RPEFS +S+ L+K KRHS+S P LH+
Sbjct: 235 LTTTNSCPPKPSPVGSNEDLVGFKRLLMTWPIPGRKITTEDDFEDELLSESRE-FIEKLILQGRRSLEDFSIPYQSVEIIECLKQGARCKIYRGRWHGDVTVHVFQDKD-DVTDTFWKNLTKLCRIRHENIILFMAACTKSPDLAVVTSYHRGTSLYEHIHIKHEKITMYDKVQILRQVALGMGYLHAKG--IALKCLNSHNVFLCPKVKLSAMDWG-IAESVHERSDYAIIPPHQLTYVAPEVLACVSVVPPRLVTTTTAYSKETDIFAFGTVMYEVFAGRYPYDDLNPMTLIWQVCGGRRQLLDKVRCTTPIKKMINSCWCQEPFHRPEFSHLSKSLLKNFPLHKRHSTSEPKKLHK 588
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: ksr1b (kinase suppressor of ras 1b [Source:ZFIN;Acc:ZDB-GENE-040724-45]) HSP 1 Score: 145.206 bits (365), Expect = 3.695e-35 Identity = 93/304 (30.59%), Postives = 161/304 (52.96%), Query Frame = 2
Query: 1439 FILERVDKCINRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSR---FWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEP-KVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHS 2320
F +R + E+++PF ++ LGE + G KVY+G WHG+V+V + E +D + + F + V N RHEN+VLFMGA + PP ++TS C G +LY + S+ + + + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + E + + +P ++Y APEI+ M + + +P F + DVY+FG + YE+ +P T I + +G+ R ++++ + V +I+ CWS + RP FS ++ +L K +R S
Sbjct: 484 FSRKRSQTSVYLQEWHVPFHELNLGELIGKGRWGKVYRGRWHGEVAVRLLE-IDGNNQGHLKLFKKEVMNYRQTRHENVVLFMGACMNPPQLAIITSFCKGRTLYSFVRDSKNSLDLNKTRQIAQEIVKGMGYLHAKE--IVHKDLKSKNVFYDANKVVITDFGLFGMSGV-VQEDRRENELKLPHGWIYYLAPEIVRRMCPGNDEEHLP---FSKAADVYAFGTIWYELQTRDWPITNQPAEAAIWQLGSGEGIRQQLRQISLGKEVTDILSACWSFELEDRPTFSQLADQLEKLPKLNRRLS 780
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: ksr2 (kinase suppressor of ras 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8047]) HSP 1 Score: 143.28 bits (360), Expect = 2.319e-34 Identity = 104/352 (29.55%), Postives = 178/352 (50.57%), Query Frame = 2
Query: 1322 SLSSQYSRTNRGLLCSSWPPSGRRIFYIDNDLMSNCDEDFILERVDKCINRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-----EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYII-ETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
SL+ SR + LCS R ++ L+S +F + I E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMG + PPH ++TS C G +LY I ++ + + + +++ + +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APEI+ E LP F + +DV++FG + YE+H +P KN+ E II + +G +P++ ++ + + +I+ CW+H+ RP FS + EL+++ R R S PG+
Sbjct: 577 SLNEYVSRLHTRRLCSH-----HRFEEMNLSLLSA--RNFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRNTRHENVVLFMGVCMSPPHLAIITSLCKGRTLYTVIRDAKVILDVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRREDKLRIPSGWLCHLAPEIIRQLSPETAEDQLP-------FSKQSDVFAFGTIWYELHAREWP-FKNQPPEVIIWQVGSGMKPNLTQIGMGKEISDILLFCWAHEQEERPSFSKLV-ELLEKLPKRNRRLSH-PGHF 909
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: ksr1a (kinase suppressor of ras 1a [Source:ZFIN;Acc:ZDB-GENE-091113-34]) HSP 1 Score: 141.354 bits (355), Expect = 5.939e-34 Identity = 92/297 (30.98%), Postives = 155/297 (52.19%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEP-KVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEIL-EMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + LGE + G +V++G WHG+V++ + E + D F + V N RHEN+VLFMGA + PPH ++TS C G +LY + ++ + + + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + E + + +P + Y APEI+ +M + +P F DVY+FG + YE+ +P T V I + +G+ + + E+ + V I+ CWS+D RP F+ ++ L K +R S PG+
Sbjct: 541 EWDIPFEQLDLGELIGKGRWGRVHRGRWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMAPPHLAIITSFCKGRTLYSVVRDTKNTLDINKTRQIAQEIVKGMGYLHAKG--IVHKDLKSKNVFHDTNKVVITDFGLFGISGV-VQEGRRENELRLPHGWICYLAPEIVRKMSPGNNEDRLP---FSNAADVYAFGTIWYELQARDWPITNQPVEATIWQVGSGEGIKKVLTEISLGKEVTEILSACWSYDSRDRPTFTQLADMLEKLPKLNRRLSH--PGHF 829
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: braf (B-Raf proto-oncogene, serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-040805-1]) HSP 1 Score: 112.849 bits (281), Expect = 4.688e-25 Identity = 82/247 (33.20%), Postives = 124/247 (50.20%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENL--DHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLD--CSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP-STKNEVNEYIIETCTGK-RPDIKEMRA 2200
++ IP G I LG+ + SG+ VYKG WHGDV+V M + F V L RH NI+LFMG + +P +VT C G SLY +H+ K + + RQ AQ + YLHAK+ II R L S NI+L + + + D + + + + G ++W APE++ + K+ Y Q +DVY+FG++ YE+ G P S N ++ I G PD+ ++R+
Sbjct: 458 DWEIPEGQITLGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRLQDKN-------PYSFQ-SDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLSPDLSKVRS 692
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: araf (A-Raf proto-oncogene, serine/threonine kinase [Source:NCBI gene;Acc:103043654]) HSP 1 Score: 109.383 bits (272), Expect = 3.746e-24 Identity = 85/292 (29.11%), Postives = 138/292 (47.26%), Query Frame = 2
Query: 1421 SNCDEDFILERVDKCINRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDY-DEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP-STKNEVNEYIIETCTGK-RPDIKEM--RASETVKNIIRECWSHDPLARPEFSDI 2275
S+ DE + RV + Y + + ++ + + + SG+ VYKG WHGDV++ + + + ++ F + L RH NI+LFMG +P HF ++T C G SLY +H++ K ++ + RQ AQ + YLHAK II R L S NI+L + + D V P + + APE++ M P Y Q +DVY +G++ +E+ G P S N ++ I G PD+ ++ +++K +I +C RP F I
Sbjct: 284 SSSDEKKKVHRVGYRDSSYYWEVHSREVNMQKRIGSGSFGTVYKGKWHGDVAIKILKVTEPTPEQLQAFRNEMQVLRKTRHVNILLFMGFMTKP-HFAIITQWCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKN--IIHRDLKSNNIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQPSGSILWMAPEVIRMQD-------PNPYTFQ-SDVYGYGVVLFELMSGTLPYSNINNRDQIIFMVGRGYLSPDLSKLTNNCPKSMKRLIIDCLKFKRDERPLFPQI 564
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: braf (B-Raf proto-oncogene, serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-040805-1]) HSP 1 Score: 116.316 bits (290), Expect = 8.609e-27 Identity = 103/366 (28.14%), Postives = 171/366 (46.72%), Query Frame = 2
Query: 1271 LSHACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYIDNDLMSNCDEDFILERVDKCINRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDH--DERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSL----LDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP-STKNEVNEYIIETCTGK-RPDIKEMRAS--ETVKNIIRECWSHDPLARPEFSDI--SRELMKRDTTRKRHSSSVP 2332
L + LP H+ LS+ T G + PPS + + ++ ++ ++++ + + ++ IP G I G+ + SG+ VYKG WHGDV+V M D + F V L RH NI+LFMG + +P +VT C G SLY +H+ K + + RQ AQ + YLHAK+ II R L S NI+L + + + L + L+ P + + APE++ M ++ Y Q +DVY+FG++ +E+ + P + N ++ I G PD+ ++R++ +T+K ++ +C RP F I S E + R + S+S P
Sbjct: 405 LPYCTPLPAHA----GAGLSATPPATLPGSIAMPKPPS--KSLPRERKPSASSEDRARMKQIGRRDSSDDWEIPEGQITAGQRIGSGSFGTVYKGKWHGDVAVKMLNVTDPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKP-QLAIVTQWCEGSSLYRHLHILETKFEIFQLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHDDLTVKIGDFGLATVKARWSGSHQLEQ---PSGSILWMAPEVIRMKERN-------PYSFQ-SDVYAFGIVLFELMSCQLPYCSINNRDQIIFMVGRGYLSPDLSKVRSNCPKTMKRLMIDCLKKKREDRPLFPQILASIEQLARSLPKIHRSASEP 750
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006323.1 (pep scaffold:Pmarinus_7.0:GL480385:15686:21285:-1 gene:ENSPMAG00000005719.1 transcript:ENSPMAT00000006323.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 107.457 bits (267), Expect = 6.428e-26 Identity = 82/272 (30.15%), Postives = 135/272 (49.63%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERS---RFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTS-ACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLSLLDCSHLDYDEIDTLDN-----VCIPGHLVWYAAPEILEMGGKDLPKIIPEKY-FVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPD------IKEMRASETVKNIIRECWSH 2242
E++IP+ + + E + G KVY+G WHG V++ + E ++ D + F V RHEN+VLFMGA + PPH +VT G +LY + S+ + + + ++IA+ +GYLHAK II + L S+NI+ + KVV++ + D +N + IP + Y +PEI+ + P I +K F + DVY+FG + YE+ +P I + G +PD +KE+ +T+ I C+ +
Sbjct: 10 EWDIPYEQLAVDELIGRGRFGKVYRGRWHGQVAIRLIE-MERDNEAFVKLFKREVMGYRQTRHENVVLFMGACMNPPHLAIVTRWMALGRTLYSYVRDSKTNLDINKIRQIAQEIAKGLGYLHAKG--IIHKDLKSKNIFYDNGKVVITDFGLFSISGVMQDGSENRRDSELKIPHGWLCYLSPEIIRVLS---PAIDADKLPFSKPADVYAFGTIWYELQARDWPFHGQPAEAIIWQVGNGLKPDPTPVSMVKEILVRDTLHLEIFCCFYY 275
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k9 (mitogen-activated protein kinase kinase kinase 9 [Source:ZFIN;Acc:ZDB-GENE-081113-5]) HSP 1 Score: 79.7221 bits (195), Expect = 2.589e-15 Identity = 76/301 (25.25%), Postives = 119/301 (39.53%), Query Frame = 2
Query: 1448 ERVDKCINRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDER-SRFWENVSN----LTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKT-KPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMG--GKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP------------STKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELM 2290
ER + F ++ L E + +G KVY+G W G+ D DE S ENV +M+RH NI+ ++ P+ ++ G +L ++ ++ + QIA+ + YLH + II R L S N+ V + L + D E TL WY + G P++I F + +DV+S+G+L +E+ G P N++ I TC E ++ ECW DP +RP FS I EL+
Sbjct: 72 ERAPGLFADPPVEVDFAELSLEEIIGAGGFGKVYRGTWRGEEVAVKAARQDPDEDISVTMENVRQEGKLFSMLRHPNIIALKAVCLQAPNLCLIMEYARGGALNRA--LAGRRIHPHILLDWAVQIARGMKYLHDEAIVNIIHRDLKSCNV-----VKVLLQERVENDDLEAKTLKITDFGLAREWYKTTMMSAAGTYAWMAPEVIKSSTFSKGSDVWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCP------------EPFSKLMTECWDPDPHSRPPFSRILDELV 353
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004131.1 (pep scaffold:Pmarinus_7.0:GL490249:322:4273:1 gene:ENSPMAG00000003774.1 transcript:ENSPMAT00000004131.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 71.633 bits (174), Expect = 6.815e-14 Identity = 69/281 (24.56%), Postives = 122/281 (43.42%), Query Frame = 2
Query: 1481 FNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLD--CSHLDYDEIDTLDNVCIPGHLV---WYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHM-GRYPSTKN----EVNEYIIETCTG--KRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISREL 2287
+++P I++G + GN +VY+G W+ V + + F + V + +HEN++ E + +VT ++ + ++ + ++ + IA + YL K I L RNI + + + D SH E+DT + GH+V W A P+++ + F + +DV+SFG+L YE+ G+ P + +V + I C G KRPD V +I++ CW+ + RP F + REL
Sbjct: 10 WHVPRSSIKMGNLLGRGNFGEVYEGRWNDTTDVAIKIVRTNSSFDTFMKEVKTMISFKHENVLQIYAVCKEKWPYWIVTELVPYGNMLHYLGRFGHELSEVERLYMAFGIASGMAYL--SKKRCIHCDLAGRNILMGQHNICKVADFGLSH-KLKEMDTEEYYDATGHVVPFQWMA------------PEVLIQLKFTRKSDVWSFGVLLYELFTDGKRPYAGDLGAQQVQDLI--KCGGRLKRPDA----CPNVVYHIMQRCWNFEHRKRPPFCKLKREL 269
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008193.1 (pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-1 gene:ENSPMAG00000007385.1 transcript:ENSPMAT00000008193.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 68.1662 bits (165), Expect = 3.400e-12 Identity = 68/270 (25.19%), Postives = 117/270 (43.33%), Query Frame = 2
Query: 1481 FNIPFGDIRLGECMKSGNKRKVYKGHWHGD-VSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYL--EPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRAS--ETVKNIIRECWSHDPLARPEFSDI 2275
+ +PF +I + + SG + V+ G + G+ V+V R + ++ +L +RH NI+ F G P + ++ C LYE + R ++ V R IA+ + YLH II R L S N+ + + +V +S S + E T + G + W A P++I + + D++SFG++ +E+ G P +V+ I G + AS E K ++ +CW+ P RP F I
Sbjct: 7 WEVPFEEISELQWLGSGAQGAVFLGKFRGEHVAVKKV-------REQKETDIKHLHKLRHPNIITFKGVCTHAPCYCIIMEYCAQGQLYEVLRAGR-RISPELLVGWTRGIARGMSYLH--LHKIIHRDLKSPNVLITHDDEVKISDFGTSK-EMREKST--RMSFAGTVAWMA------------PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY--RDVDSSAIIWGVGSNSLHLPIPASCPEGFKILLTQCWNSKPRNRPSFRQI 249
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CMK1 (Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication [Source:SGD;Acc:S000001910]) HSP 1 Score: 61.6178 bits (148), Expect = 2.911e-10 Identity = 58/230 (25.22%), Postives = 98/230 (42.61%), Query Frame = 2
Query: 1619 FWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNI-YLE-----PKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMR-----ASETVKNIIRECWSHDPLARPEFSDI 2275
++ + L + H NIV F F ++T G L+++I + + K + V +L +I AV Y+H++ I+ R L N+ Y++ P VV L DE + + P + Y APE+L G P D++S G++TY + G V +++ E TG+ P +K R S K I + + DP RP +++
Sbjct: 83 LYDELDILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRI-LKKGKFTEEDAVRILVEILSAVKYMHSQN--IVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDE----ELLYKPAGSLGYVAPEVLTQDGHGKP-----------CDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYP-VKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAEL 293
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354]) HSP 1 Score: 52.7582 bits (125), Expect = 2.697e-7 Identity = 50/210 (23.81%), Postives = 86/210 (40.95%), Query Frame = 2
Query: 1640 LTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCS-HLDYDEIDTLDN--VCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARP 2260
L + HENIV + GAS E + + G S+ ++ + +S + RQI V YLH K II R + NI ++ K + + D ++ N + G + W + P+++ + D++S G + E+ G++P + I + T P+I SE KN +R+ + D RP
Sbjct: 508 LKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLN-NYGPFEESLITNFTRQILIGVAYLHKKN--IIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMS------------PEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIGTNTTPEIPSWATSEG-KNFLRKAFELDYQYRP 701
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: GCN2 (Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691]) HSP 1 Score: 50.447 bits (119), Expect = 1.429e-6 Identity = 60/238 (25.21%), Postives = 96/238 (40.34%), Query Frame = 2
Query: 1598 DHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE------------PKVVLSLLDCSHLDYDEI-DTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKR----PDIKEMRASETVKNIIRECWSHDPLARP 2260
D D+ S+ +NV R N V M A + + C +LY+ IH ++ L RQI +A+ Y+H++ II R L NI+++ K V LD LD + + DN+ Y A E+L+ G ++ + D+YS G++ +E+ YP + I++ PD + + + K IIR HDP RP
Sbjct: 754 DTDKESKSIQNVP-----RRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALSYIHSQG--IIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIGTAMYVATEVLDGTG----------HYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKKLRSVSIEFPPDFDDNKM-KVEKKIIRLLIDHDPNKRP 970
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO47467 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM99]) HSP 1 Score: 140.198 bits (352), Expect = 1.274e-36 Identity = 96/312 (30.77%), Postives = 150/312 (48.08%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMI-----RHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHL------VWYAAPEILE--MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSLICN 2368
E+ +PF +I + + + SG KVY+G WHG+V+V M E N ++ + F V + RH+N VLFMGA ++PP ++TS C G +LY +H+ ++ + + QIAQ +GYLHA+ I+ L S+N++LE + D Y PG+L ++Y APE++ +D P+ K F TDVYSFG + YE+ G +P K I + G + + VK + CW+ +P +RP FS + + + D K+H LH+ S C
Sbjct: 3 EWVVPFEEIEIFDVLGSGRFGKVYRGRWHGEVAVKMIEIDNPTEEQLNAFKFQVRGEVSVFSLKTRHDNTVLFMGACMDPPKLAIITSLCRGYTLYTHVHIRKDNFPLAKIAQITTQIAQGMGYLHARG--IVHTDLRSKNVFLELNSKAVITDFGL--YSVAGLTARSARPGYLMVPYGWLYYLAPEVIRTLTPFQDAPE---SKQFTTKTDVYSFGTVWYEMIAGGWPWKKQNPESIIYKVGKGHKQSLNIHDIPGEVKEALILCWAQNPESRPTFSQLLKTI---DRLPKKH------RLHRSPSQPCT 298
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO47089 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN75]) HSP 1 Score: 102.449 bits (254), Expect = 3.280e-22 Identity = 89/306 (29.08%), Postives = 141/306 (46.08%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHD--ERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDC---------SHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK---RPDIKEMR--ASETVKNIIRECWSHDPLARPEFSDI--SRELMKRDTTRKRHSSSVPGNL 2341
++ I G++++G + SG+ VYKG+WHG V++ D + F V+ L RH N++LFMG + P +VT C G SLY +H+ + + + RQ AQ + YLHAK II R L S NI+L+ + + + D S Y E + G ++W AA E++ M + P Y +DVY+FG++ YE+ P + I+ G+ RPD+ + R + + EC + RP F I S E + R + + S+S P N+
Sbjct: 427 DWEILEGEVQMGPRIGSGSYGTVYKGNWHGAVAIKTLNVTDPTPTQLQAFKNEVAVLRKTRHVNVLLFMGC-MSKPKLAIVTQWCEGSSLYRHLHVLENRFEVLNLIDIARQTAQGMDYLHAKK--IIHRDLKSNNIFLQEDLTVKIGDFGLATIKTRWSGSQYSEQPS-------GSILWMAA-EVIRM-------LDPNPYSFH-SDVYAFGIVLYELLSSSLPYAHVGNKDQILYM-VGRGYLRPDMSKARNDIPKAFNRLCLECIKFNRDERPLFPQILASLEAIHRALPKIQRSTSEPWNI 712
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36442 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIN7]) HSP 1 Score: 92.8189 bits (229), Expect = 1.515e-19 Identity = 73/282 (25.89%), Postives = 122/282 (43.26%), Query Frame = 2
Query: 1481 FNIPFGDIRLGECMKSGNKRKVYKGHWHGD-VSVFMFENLDHDERSRFWENVSN----LTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRR-LNSRNIYLEPKV-------VLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISREL 2287
IPF +I L + + G KVY+G W + V+V + ++++ ++ ++V +M+RH+NIV +G S+E P+ +V G +L + + S ++ QIAQ + YLH++ IV R L S NI L K+ +L + D EI + G W A P++I F +DV+S+G++ +E+ G+ P E E KN++ +CW+ DP RP F + L
Sbjct: 68 LEIPFRNIELIDVIGVGAFGKVYRGIWRDEEVAVKVARTDNYEDFTQTLDSVKKEARIFSMLRHQNIVGLLGVSLEQPNLCLVLEYARGGALSRALSSYNRNIPPSVLLNWAIQIAQGMFYLHSEAPVTIVHRDLKSGNILLHYKINESDFNNILKITDFGLA--REIANTTRMSAAGTYAWMA------------PEVIRTNTFSFASDVWSYGVVLWELLTGQVPYKDVEALAVAYGVAMNSLTLPIPTTCPEVFKNLMADCWNQDPHKRPTFKAVLEAL 335
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80]) HSP 1 Score: 71.2478 bits (173), Expect = 1.127e-12 Identity = 59/223 (26.46%), Postives = 102/223 (45.74%), Query Frame = 2
Query: 1649 IRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVR---RLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVN-EYIIETCTGK-----RPDIKEM-RASETVKNIIRECWSHDPLARPEFSDISREL 2287
IRH+N+ F+GA + PP+ +V C+ SL + + K+ F SLL I + + YLH +R L S N ++ + VL + D + + + APEIL + + P K DVYSF ++ E H P + N + + IIE RP + + +E +++++++CW+ DP RP+F++I + +
Sbjct: 29 IRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSD----IRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIETNWRDLLWVAPEILRIPSR------PPKG-THKGDVYSFSIILQEFHTRDGPYSANYMEPKAIIEKVRKSEFPPYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTV 240
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO47144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMS1]) HSP 1 Score: 67.781 bits (164), Expect = 3.162e-12 Identity = 68/254 (26.77%), Postives = 100/254 (39.37%), Query Frame = 2
Query: 1544 VYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMR-----QSFKVSLLRQIAQAVGYLHA-KTKPIIVRRLNSRNIYL-EPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYP---STKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDI 2275
VYK W V + E+ F V L+ + H NI+ GA + +V G SLY +H + R S +S Q A V YLH+ K K II R L N+ L V+ + D + +N G W APE+ E + + DVYSFG++ +E+ R P + + G+RP + + + ++ +I CW DP RP FS I
Sbjct: 22 VYKARWREKFIVAVKTIESEAEKKAFIVEVQQLSRVSHRNIIKLYGAVTKHEPVCLVMEYAEGGSLYNLLHWKKSTSRAPIYTASHVISWALQCASGVEYLHSMKPKAIIHRDLKPPNLLLTRCGTVVKICDFGTACDLKTYMTNN---KGSAAW-MAPEVFEGNN-----------YTEKCDVYSFGIILWEMISRRKPFDDMAGSPPFRIMWAVHIGRRPPLIK-NIPKPIEELITSCWDKDPDKRPSFSRI 259
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ksr1a (kinase suppressor of ras 1 [Source:NCBI gene;Acc:101175586]) HSP 1 Score: 144.05 bits (362), Expect = 1.222e-34 Identity = 95/303 (31.35%), Postives = 156/303 (51.49%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEP-KVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILE-MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + LGE + G KV+KG WHG+V++ + E + D F + V N RHEN+VLFMGA + PPH ++TS C G +LY + ++ + + + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + E + + +P + Y APEI++ M + +P F DVY+FG + YE+ +P T V I + +G+ R + E+ + V I+ CW+ D RP F+ ++ L K +R S PG+ + L
Sbjct: 684 EWDIPFEQLDLGELIGKGRWGKVHKGRWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMAPPHLAIITSFCKGRTLYSVVRDTKSTLDINKTRQIAQEIVKGMGYLHAKG--IVHKDLKSKNVFHDTNKVVITDFGLFGISGV-VQEGRRENKLRLPHGWICYLAPEIVQKMSPGNNEDRLP---FSTAADVYAFGTIWYELQARDWPITNQPVEATIWQVGSGQGIRNVLAEINLGKEVTEILSACWAFDHRDRPTFTQLADMLEKLPKLNRRLSH--PGHFWKSAEL 978
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ksr1a (kinase suppressor of ras 1 [Source:NCBI gene;Acc:101175586]) HSP 1 Score: 143.665 bits (361), Expect = 1.697e-34 Identity = 94/297 (31.65%), Postives = 154/297 (51.85%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFE--NLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEP-KVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILE-MGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGK--RPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + LGE + G KV+KG WHG+V++ + E + D F + V N RHEN+VLFMGA + PPH ++TS C G +LY + ++ + + + ++I + +GYLHAK I+ + L S+N++ + KVV++ L S + E + + +P + Y APEI++ M + +P F DVY+FG + YE+ +P T V I + +G+ R + E+ + V I+ CW+ D RP F+ ++ L K +R S PG+
Sbjct: 670 EWDIPFEQLDLGELIGKGRWGKVHKGRWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMAPPHLAIITSFCKGRTLYSVVRDTKSTLDINKTRQIAQEIVKGMGYLHAKG--IVHKDLKSKNVFHDTNKVVITDFGLFGISGV-VQEGRRENKLRLPHGWICYLAPEIVQKMSPGNNEDRLP---FSTAADVYAFGTIWYELQARDWPITNQPVEATIWQVGSGQGIRNVLAEINLGKEVTEILSACWAFDHRDRPTFTQLADMLEKLPKLNRRLSH--PGHF 958
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ksr2 (kinase suppressor of ras 2 [Source:NCBI gene;Acc:101156092]) HSP 1 Score: 140.584 bits (353), Expect = 1.407e-33 Identity = 92/305 (30.16%), Postives = 157/305 (51.48%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQ----AVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY + + + V+ RQIAQ +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APEI++ D + +P F + +DV++FG + YE+H +P I + +G +P++ + + + +I+ CW++ RP FS + +L+++ R R S PG+ + L
Sbjct: 653 EWDIPFEQLEIGEMIGKGRFGRVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRNTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR----DAKVALDVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRREDKLRIPSGWLCHLAPEIIQQLSPDTEEDKLP---FSKQSDVFAFGTIWYELHAREWPYKSQPAEVIIWQMGSGMKPNLAQTGMGKEILDILLLCWAYKQEERPSFSKLV-DLLEKLPKRNRRLSH-PGHFWKSAEL 946
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ksr2 (kinase suppressor of ras 2 [Source:NCBI gene;Acc:101156092]) HSP 1 Score: 140.584 bits (353), Expect = 1.595e-33 Identity = 92/305 (30.16%), Postives = 157/305 (51.48%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQ----AVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSL 2359
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY + + + V+ RQIAQ +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APEI++ D + +P F + +DV++FG + YE+H +P I + +G +P++ + + + +I+ CW++ RP FS + +L+++ R R S PG+ + L
Sbjct: 665 EWDIPFEQLEIGEMIGKGRFGRVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRNTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR----DAKVALDVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRREDKLRIPSGWLCHLAPEIIQQLSPDTEEDKLP---FSKQSDVFAFGTIWYELHAREWPYKSQPAEVIIWQMGSGMKPNLAQTGMGKEILDILLLCWAYKQEERPSFSKLV-DLLEKLPKRNRRLSH-PGHFWKSAEL 958
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ksr2 (kinase suppressor of ras 2 [Source:NCBI gene;Acc:101156092]) HSP 1 Score: 140.198 bits (352), Expect = 1.755e-33 Identity = 91/299 (30.43%), Postives = 155/299 (51.84%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMF--ENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQ----AVGYLHAKTKPIIVRRLNSRNIYLE-PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPK-IIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNL 2341
E++IPF + +GE + G +VY G WHG+V++ + E + D+ F V RHEN+VLFMGA + PPH ++TS C G +LY + + + V+ RQIAQ +GYLHAK I+ + + S+N++ + KVV++ L S + D + IP + + APEI++ D + +P F + +DV++FG + YE+H +P I + +G +P++ + + + +I+ CW++ RP FS + +L+++ R R S PG+
Sbjct: 631 EWDIPFEQLEIGEMIGKGRFGRVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRNTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR----DAKVALDVNKTRQIAQEMVKGMGYLHAKG--ILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRREDKLRIPSGWLCHLAPEIIQQLSPDTEEDKLP---FSKQSDVFAFGTIWYELHAREWPYKSQPAEVIIWQMGSGMKPNLAQTGMGKEILDILLLCWAYKQEERPSFSKLV-DLLEKLPKRNRRLSH-PGHF 918
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000026170.1 (SMESG000026170.1) HSP 1 Score: 1244.95 bits (3220), Expect = 0.000e+0 Identity = 662/681 (97.21%), Postives = 663/681 (97.36%), Query Frame = 2
Query: 338 MVDLNQDLAYESLSENSSKVXXXXXXXXXXXXXXXXXXXXXXXYRCSICNKKLAKRKARRQNAIESDDYISDPFDSKLPGSQITLTPDVALMNDKPPLSFLDPXXXXXXXXXXXXXXXXKHLFCKHCMNSRLKNENLKRDKFPNGNIPHRRDSGIFNIIKTTFYKLFDXXXXXXXXXXXENNNVSRNLKQPSPKLPRKRSSGSNGAGGYVSINSGHSEIVTTPGSSIIYDSLSADSGRQNDVSSRSGSTRNSIYSLGTLSVTTTNDLIQSSDQNEFPMEIRNQRLYSDYIQTELDYDRLNRRNPRVFGNQALSHACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYIDNDLMSNCDEDFILERVDKCI---NRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSLICNY 2371
MVDLNQDLAYESLSENSSKVTGSNHLSTSSLSGSSQTHSSNNSYRCSICNKKLAKRKARRQNAIESDDYISDPFDSKLPGSQITLTPDVALMNDKPPLSFLDPSSKNPLSSTSSISNSNKHLFCKHCMNSRLKNENLKRDKFPNGNIPHRRDSGIFNIIKTTFYKLFDPKSKSPTKSKTENNNVSRNLKQPSPKLPRKRSSGSNGAGGYVSINSGHSEIVTTPGSSIIYDSLSADSGRQNDVSSRSGSTRNSIYSL DQNEFPMEIRNQRLYSDYIQTELDYDRLNRRNPRVFGNQALSHACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYIDNDLMSNCDEDFILERVDKC+ NRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSLICNY
Sbjct: 1 MVDLNQDLAYESLSENSSKVTGSNHLSTSSLSGSSQTHSSNNSYRCSICNKKLAKRKARRQNAIESDDYISDPFDSKLPGSQITLTPDVALMNDKPPLSFLDPSSKNPLSSTSSISNSNKHLFCKHCMNSRLKNENLKRDKFPNGNIPHRRDSGIFNIIKTTFYKLFDPKSKSPTKSKTENNNVSRNLKQPSPKLPRKRSSGSNGAGGYVSINSGHSEIVTTPGSSIIYDSLSADSGRQNDVSSRSGSTRNSIYSL---------------DQNEFPMEIRNQRLYSDYIQTELDYDRLNRRNPRVFGNQALSHACLLPTHSCPPKSKSLSSQYSRTNRGLLCSSWPPSGRRIFYIDNDLMSNCDEDFILERVDKCMKSRNRYEFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERSRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMKRDTTRKRHSSSVPGNLHQDNSLICNY 666
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000029462.1 (SMESG000029462.1) HSP 1 Score: 139.043 bits (349), Expect = 3.658e-33 Identity = 93/291 (31.96%), Postives = 147/291 (50.52%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDER----SRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE--PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEM----------GGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMK 2293
E+ IP+ ++ LGE + G+ V+KG WHG+V+V + DE + F V L RHEN+VLFMGA +EPP +VT G +L+ ++H + +++ Q+A+ +GYLHAK I+ + L SRNI++E KVV+S L D + I + IP + Y APE++ +DLP F +++D+Y+FG + YEI ++P I G + +K + A E K+++ +CWS RP F++I + L K
Sbjct: 653 EWEIPYKNLELGELLGKGSFWTVFKGKWHGEVAVKIMNIDPQDENDACMAAFKSEVGALHKTRHENLVLFMGACMEPPKLAIVTQLSQGETLFYQLHSRHLSIPVIRAINIASQVAKGMGYLHAKD--ILHKDLKSRNIFIESNSKVVISDFGLFDFVRMCKQAISG-SYLRIPPGWLCYLAPELIRKLNLNSIFSNNSSEDLP-------FTKSSDIYAFGTIWYEILNSKWPFEGLPSEAIIYRVGKGIKESLKIVHAKE-FKDLLIQCWSSKADNRPAFTNIVQILEK 932
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000029462.1 (SMESG000029462.1) HSP 1 Score: 138.658 bits (348), Expect = 4.065e-33 Identity = 93/291 (31.96%), Postives = 147/291 (50.52%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDER----SRFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLE--PKVVLS---LLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEM----------GGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTKNEVNEYIIETCTGKRPDIKEMRASETVKNIIRECWSHDPLARPEFSDISRELMK 2293
E+ IP+ ++ LGE + G+ V+KG WHG+V+V + DE + F V L RHEN+VLFMGA +EPP +VT G +L+ ++H + +++ Q+A+ +GYLHAK I+ + L SRNI++E KVV+S L D + I + IP + Y APE++ +DLP F +++D+Y+FG + YEI ++P I G + +K + A E K+++ +CWS RP F++I + L K
Sbjct: 649 EWEIPYKNLELGELLGKGSFWTVFKGKWHGEVAVKIMNIDPQDENDACMAAFKSEVGALHKTRHENLVLFMGACMEPPKLAIVTQLSQGETLFYQLHSRHLSIPVIRAINIASQVAKGMGYLHAKD--ILHKDLKSRNIFIESNSKVVISDFGLFDFVRMCKQAISG-SYLRIPPGWLCYLAPELIRKLNLNSIFSNNSSEDLP-------FTKSSDIYAFGTIWYEILNSKWPFEGLPSEAIIYRVGKGIKESLKIVHAKE-FKDLLIQCWSSKADNRPAFTNIVQILEK 928
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000018974.1 (SMESG000018974.1) HSP 1 Score: 118.242 bits (295), Expect = 7.551e-27 Identity = 89/279 (31.90%), Postives = 139/279 (49.82%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERS-----RFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTK-NEVNEYIIETCTGK-RPDIKEMRASE--TVKNIIRECWSHDPLARPEFSDISREL 2287
E+ I DI G + SG+ V+KG+WHG+V++ + L+ E + F VS L RH NI+LFMG I P +VT C G SLY+ +H+ +K V + RQ AQ + YLHAK II R L S NI+L K + + D + P + + APE++ M ++ + +DVY++G++ YE+ G+ P + N ++ + GK +PD+KE+R+ +K ++ +C S RP FS I +L
Sbjct: 412 EWEILESDITRGSRIGSGSFGTVFKGYWHGNVAI---KELNVSEPTPLQLKAFKNEVSMLRKTRHVNILLFMGC-IYVPRLAIVTQWCEGSSLYKHLHVLEKKFLIPELVDISRQTAQGMEYLHAKN--IIHRDLKSSNIFLHEKTI-KIGDFGLATVKSTWSNSGFQQPTGSILWMAPEVIRMDSQNP--------YTTLSDVYAYGVVLYELTSGQLPYRRYNNRDQILFMVGRGKLKPDLKEIRSDVPLPLKRLVSDCISFISDCRPPFSQIHSKL 675
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000018974.1 (SMESG000018974.1) HSP 1 Score: 117.857 bits (294), Expect = 1.523e-26 Identity = 89/279 (31.90%), Postives = 139/279 (49.82%), Query Frame = 2
Query: 1478 EFNIPFGDIRLGECMKSGNKRKVYKGHWHGDVSVFMFENLDHDERS-----RFWENVSNLTMIRHENIVLFMGASIEPPHFLMVTSACNGPSLYEKIHMSREKMRQSFKVSLLRQIAQAVGYLHAKTKPIIVRRLNSRNIYLEPKVVLSLLDCSHLDYDEIDTLDNVCIPGHLVWYAAPEILEMGGKDLPKIIPEKYFVQTTDVYSFGMLTYEIHMGRYPSTK-NEVNEYIIETCTGK-RPDIKEMRASE--TVKNIIRECWSHDPLARPEFSDISREL 2287
E+ I DI G + SG+ V+KG+WHG+V++ + L+ E + F VS L RH NI+LFMG I P +VT C G SLY+ +H+ +K V + RQ AQ + YLHAK II R L S NI+L K + + D + P + + APE++ M ++ + +DVY++G++ YE+ G+ P + N ++ + GK +PD+KE+R+ +K ++ +C S RP FS I +L
Sbjct: 698 EWEILESDITRGSRIGSGSFGTVFKGYWHGNVAI---KELNVSEPTPLQLKAFKNEVSMLRKTRHVNILLFMGC-IYVPRLAIVTQWCEGSSLYKHLHVLEKKFLIPELVDISRQTAQGMEYLHAKN--IIHRDLKSSNIFLHEKTI-KIGDFGLATVKSTWSNSGFQQPTGSILWMAPEVIRMDSQNP--------YTTLSDVYAYGVVLYELTSGQLPYRRYNNRDQILFMVGRGKLKPDLKEIRSDVPLPLKRLVSDCISFISDCRPPFSQIHSKL 961 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 3
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30034929 ID=SMED30034929|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2980bpback to top protein sequence of SMED30034929-orf-1 >SMED30034929-orf-1 ID=SMED30034929-orf-1|Name=SMED30034929-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=679bp MVDLNQDLAYESLSENSSKVTGSNHLSTSSLSGSSQTHSSNNSYRCSICNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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