Guanylate cyclase domain-containing protein

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D  + + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F +E RG + ++GK
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGT---EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK 595          

Query:  162 IYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D  + + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F +E RG + ++GK
Sbjct:   22 IYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGT---EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK 575          

Query:  162 IYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D  + + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F +E RG + ++GK
Sbjct:   74 IYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGT---EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK 627          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQ----------------------NLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+Q                      NLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D  + + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F +E RG + ++GK
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQKNESKHISDLHHCFLGIYLCCNNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGT---EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK 617          

Query:  297 VRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D  + + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F +E RG + ++GK
Sbjct:   19 LRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGT---EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK 527          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENV--LKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLH--TTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK----FEVESRGNIEIRGKGRLYTYLLKEN 2009
            MFG +    +++V    G + WE +  + +  L  + +  H Y++    +L+N   N+     E  +E  G       +     + +R +      F+ +LD LH     +    K   P FR D +      + LHYYSKR  L  +V+ ++R + + ++  E+ +++     E           LD F  E  V   ++ Q +     Q  ++       K D                    S++  ST +   Y+           + +SDF   FPYHI FD  + ++  G  ++        +   +T  LELVHP    F++ +I+ Y     V + +   ++  N   +   +  +G M+ +     ILY+CS  V  +  + +  +H+SD+  HD T+ +   +Q+           +     L    Q +  +    D  E    ++P  +AD +++G+ ++ K + +C++LF D+V F  I    +P +V+T+LNDL+ +FDRL  +HD +KV+ IGDAY+IV G+P    NHAER+  +++ ML  S+L   P  +       +  R+G+H G V+ GV+G  + R+ + G+ V +A++MES+GI  ++H+SE+   +L   K    +    RGN EIRGKG +YTY L+ N
Sbjct:    1 MFGWIHESFRQLVTRKYGKDIWEKIVHMSKFELGTESEIAHYYNDDETLRLVNSMANVIGIPIEEIWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHVVYKTKLRGPSFRCDVQADG--TLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQERKQEH----------LDAFVTEHVV--FVITQIENANSTQPKSI-----SSKAD--------------------SQIDLSTGI---YE-----------ISSSDFSLAFPYHICFDPDLFVEHFGNFIKKTFPNAMRQETRVTDLLELVHP-EVPFSYESIKYYKNSLFVFRLKGLGDIVHNANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERNLHLSDMQRHDGTRDVIMLNQSRMSQVELNRTLEETTKKLKKMAQELEIEKQKTD--ELLCELMPASVADSLRSGKAMDAKEFADCTLLFTDIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVLNISIGMLMESKLVLSPITHKP-----IKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSET--GKLNGLKANPSYVFIDRGNTEIRGKGMMYTYFLERN 601          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQET---HIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADI--PLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQM-QLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNL------------------------TGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSE-LKPFKFEVESRGNIEIRGKGRLYTYLL 2000
            MFG +   ++++V+   G + W  VL+R G  E+ +E    H Y +     L++    +    ++  +E+ G       +     + VR +  +   F+ NLD LH        KA++  P FR   E      + LHY++ R  L  +V+ +++ + K VF   +DI ++ +       H+                         NGE       VE      +H+     +   P  R  SD S   A T +   +  +   I  +L +   DF    PYH + D S  L Q G ++   I  E       I +  E+  P +   +F NI  +I    VL+ + + L                          N   +G  L  +GQM+ LS K  I+YLCSPYV +++ + Q GM ++ +P HD T+ L   +Q     +E   +     + LE    ++   +     D  L +    M+PR IA  + +G+ +E   Y   +++FCDL  F  I+    P  ++ +LN++  K DR+  +  V+KV+ + D+Y+ VSGIP     HAE +  +AL M++ +R    P N         L RIGLHSG +I GV+G  + R+ + GE V +AS+MES G+  ++  S   YS+ ++  +FE   RG I ++G+G + TY L
Sbjct:    1 MFGFIHESIRQLVIRKYGEDVWLQVLERSGF-ENGKENIVNHYYSDTDTYVLVDSVSIVLKVTKDQIWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFR--CEENPDGTLMLHYFTGRPGLYHIVKGVVKEVAKLVFN--LDISLVVQGRTQRSVHM------------------------NNGE------RVE------EHVIFLIKNVEEP--RRDSDTSTTSALTSVEPDFGEI---IDDNLKVSLQDFSRALPYHFVLDESCRLVQCGDELYNHIPNELLQPGTPILRIFEINRP-QIPLDFENICNFINAVFVLQVKTSPLRKKHMNAMTKEEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETM--THELEVERQKTDSILKD----MLPRKIAKQLLSGEHLEPCEYE-ATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYTSEHAENMCHVALGMMWEARSVMDPVN-----KTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFL 628          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQE--THIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADI--PLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQ-LIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNL-----------------------TGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSE-LKPFKFEVESRGNIEIRGKGRLYTYLL 2000
            MFG +   ++++V+ + G + W  VL+R G     +    H Y +     L++    +    ++  +E+ G       +     + VR +  +   F+ NLD LH        KA++  P FR   E      + LHY++ R  L  +V+ +++ + K VF  ++DI ++ +       H+                         NGE       VE      +H+     + + P          L  ST       N    +  +L +   DF    PYH + D S  L Q G ++   I  E       I +  E+  P +   +F NI  +I    VL+ + + L                         N   +G  L  +GQM+ L++K  I+YLCSPYV +++ + Q+GM ++ +P HD T+ L   +Q     +E   +     + LE    +    +     D  L +    M+PR IA  + +G+ +E   +   +++FCDL  F   +   SP +++ MLN++  K DR+  +  V+KV+ + D+Y+ VSGIP     HAE +  +AL M++ +R    P +         L RIG+HSG +  GV+G    ++ + GE V +AS+MES G+  ++  S+  Y + ++  +FE   RG I+++ +G   TY L
Sbjct:    1 MFGFIHESIRQLVIRNYGEDTWTQVLERSGFESGKENIMNHYYSDTDTYVLVDSVSLVLKVTKDQVWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFR--CEETPDGTLLLHYFTGRPGLYHIVKGVVKEVAKRVF--DLDITLVVQGRTQRSVHM------------------------NNGER------VE------EHVVFLINNLSEPRRDSEGSEVSLLTSTN-----ANFPTIVDDTLGISLDDFSKALPYHFVIDESCKLVQCGSELHNHIPNELLQPGTPILRIFEINRP-QIPLDFENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMETLDEDATNELTQGHHLKLKGQMMLLASKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETM--TRELELERQKTDSILKD----MLPRRIAQQLLSGEHIEACEHE-ATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAVSGIPDYTPEHAENMCHVALGMMWEARSVIDPVS-----KTPFLLRIGIHSGTITAGVVGTVHPKYCLFGETVTLASQMESLGMAGKIQCSKWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFL 627          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLH--TTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENES---ITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGV------LYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHR-FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL-KPFK--FEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDT 2063
            M G   + V  ++L   G E  E +L++ G  ED  F     YD+    ++   A  +     +  +E+ GE            + +  +  +  EF+ NL+ +H     +A   +   P F+ +  G S   ++LHY+S R+ L  +V+ L+R   +T+F+ ++ + ++  N E  +     HVI+SV  D+                + G+   H                          +FR+ ++   A +  L           +++L+   DF +IFPYH+ F+  M ++  GI +   ++E+  EN+    ++  ++LV P      + N+  Y+    + + +H++   N   +G        L  +G+M+ +++ + I+++CSP+V  +  I    ++ISD+P HD T+ L   +Q+  C +   NK   LE  +    +   + ++     +   F  VP  IA+ ++  + V  + + +CS++F D+  F  I  + SPTE++T++ DL  +FDR+ E H  +KV  + D+Y+IV G+P   + H E    +AL +L+ ++    P      +   V  RIG+H G V+ G++ +   RF ++G  V +   + SH  P +V +S ++ + + K  K  F   + G +E++  G++ T+ L++N+  +   I+   K  +D+
Sbjct:    1 MIGWTHVCVSALILRKYGPEVLEEILRKAGYQEDIKFDIQCYYDDTETMRIFRVAATVLGLSVDDMWEMYGEFLITHACETGWQKMLFCMANNLQEFLDNLNSMHYFIDQIAFKSEMKGPTFQCEPFGES--GLKLHYFSFRQGLFPIVKGLVRKTARTLFEMDVKVCMLERNQERRKSGMVEHVIFSVEPDD--------------NHRKGKRLFH--------------------------KFRNTKTTENAPSFTL----------SSTILVGLRDFKNIFPYHVCFNKQMIIEHIGIYL---LREYGLENKKTLKVSDLMQLVQPSDIQLTYKNVLSYLNTLFIFQLKHHS-KRNEVQEGSSEAFQQPLVLKGEMMPINDGNSIIFICSPHVTTVRDILNLKLYISDMPMHDATRDLVMLNQSRIC-QMELNKK--LEETMKKMKKMTEELEVKKSQTDRLLFEFVPPVIAEALRAAKTVPAQEFSDCSVIFTDIPDFFTISVNCSPTEIITVVTDLFHRFDRIIEKHKGYKVLSLMDSYLIVGGVPNANQYHCEDSLNLALGLLFEAKQVVVP-----KLERSVRLRIGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVLVSNAVRTMVTKHLKSIFVFNANGYLELQS-GKVLTHFLEKNEKCSVWDIVDRDKATNDS 629          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQE--THIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADI--PLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENH--------EDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQM-QLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR---------HNNLTGNFTPKGGVLY----------------FRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPI--FDDDLDGDLGEHRF---AMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-KFEVESRGNIEIRGKGRLYTYLL 2000
            MFG +   ++++++   G   W  VL+R G     +    H Y +     L++    I    RE  +E+ G       +       +R +  +   F+ NLD LH        KA++  P FR   E      + LHYY+ R  L  +V+ +LR   K VFK ++ + I             E    HVI+ V                  T ++ E  L    V+H                                        N K R      L   DF   FPYH++ D    + Q G ++   I ++       + +  E+  P +   +F +I  +I    VL+ +          N            LY                 +GQM+ +S+   I+YLCSPYV ++  + Q+G+ ++ +P HD T+ L   +Q     +R ++    L+  L +N + +     DL+ + G+       M+P  +A  +K G  VE + Y   +++F D+  F  IV   +P +++ +LN+L  KFDRL  +   +KV+ +GD+Y+ V GIP  + +H E I  +AL M+  +R    P    +N    +  R G+HSG V+ GV+G  + R+ + G+ V  +SRMESH    R+H SE+     +   +FE E RG ++I+GKG + TY L
Sbjct:    1 MFGFIHESIRQLMIRTYGEAFWSKVLERAGFEAGKENIINHYYSDADTFSLVDAVSVILKVTREQVWEMYGCFLIQYTMETGWDDLIRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFR--CEDNPDGTITLHYYTGRPGLYPIVKGVLREAAKRVFKLDVSMTITGRTQRSVQMATGERIEEHVIFLV--------------KTLNTDQSNEEALGTAVVQHSN--------------------------------------NYKIR------LTHMDFISTFPYHMVVDQDCKIVQVGRELYNHIPKDLLSVGTPLMRIFEVTRP-QIPLDFDSICNFINAVFVLQVKTTPMEFQRNANKRAAQAIEASENLYEDNNGALALSQSQHLKLKGQMMLMSSGGHIMYLCSPYVTSIPELLQYGLRLTAMPIHDPTRDLILLNQ-----QRLSDVEMNLQ--LEANNEQLENMAKDLEVEKGKTDALLREMLPPSVAQQLKQGLSVEAREYEEATVMFTDVPTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAYKVETVGDSYMSVGGIPDLVDDHCEVICHLALGMVMEARTVCDPI---TNTPLHI--RAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRMESHSPIGRIHCSENAKKCAESTGRFEFEPRGRVQIKGKGEMNTYFL 623          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGL-TEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILD--EFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQG--SQAIE---CFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRV--EGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQ 2012
            M+G L   + E + +  G EKWE++ ++ G+ +  F    +Y E + ++L  +A  +       F + MG  +   +      + + +LG    +F+  LD LH      YP+   P F  + E  +   + LHY SKR          +R + +  + KE+ I ++ E    D  HV + +  D   F +        +A T++    + H     H   ++    M FG D +     RS  + L     M++  + +  +I A    D       F +  I + + N+ +  + +  + + F  +NE + +H +   P +                           +   KG ++Y       + N  +I++L +P + +L ++   G++I+D+  HD ++ L      Q++E      +   K   LE  +      + D+++     E  + M+P+ +AD ++ G+      +M+ + SILF D+V F  I    +P EV++MLN ++  FD+L E + V+KV+ IGDAY++V+G P    NHAER+  MAL M+ A      P     + G  +  R+G+HSG V+ G++G  + R+ + G+ V  ASRMES  I  +VH+SES    + P  +++  RG I+++GKG + TY L+E +
Sbjct:    1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENE--TKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEILFDTVHVTFQLTFDNRAFTLAS------LAMTRE----EKHLPISAHVLFEIFPFCMVFGADMV----VRSIGNSL-----MVILPELLGKKITA--WFDLVRPLIAFKFQTILNRTNNIFEL-VTVDPVTERFDVQNEDLLQHEDGSEPEK---------------------------SLRLKGQMVY-------MENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMR-----LLDEEMR-RTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDP-----STGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGP-NYKIIERGEIDVKGKGTMGTYWLEERE 596          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGL-TEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILD--EFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQG--SQAIE---CFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRV--EGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQ 2012
            M+G L   + E + +  G EKWE++ ++ G+ +  F    +Y E + ++L  +A  +       F + MG  +   +      + + +LG    +F+  LD LH      YP+   P F  + E  +   + LHY SKR          +R + +  + KE+ I ++ E    D  HV + +  D   F +        +A T++    + H     H   ++    M FG D +     RS  + L     M++  + +  +I A    D       F +  I + + N+ +  + +  + + F  +NE + +H +   P +                           +   KG ++Y       + N  +I++L +P + +L ++   G++I+D+  HD ++ L      Q++E      +   K   LE  +      + D+++     E  + M+P+ +AD ++ G+      +M+ + SILF D+V F  I    +P EV++MLN ++  FD+L E + V+KV+ IGDAY++V+G P    NHAER+  MAL M+ A      P     + G  +  R+G+HSG V+ G++G  + R+ + G+ V  ASRMES  I  +VH+SES    + P  +++  RG I+++GKG + TY L+E +
Sbjct:    1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENE--TKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEILFDTVHVTFQLTFDNRAFTLAS------LAMTRE----EKHLPISAHVLFEIFPFCMVFGADMV----VRSIGNSL-----MVILPELLGKKITA--WFDLVRPLIAFKFQTILNRTNNIFEL-VTVDPVTERFDVQNEDLLQHEDGSEPEK---------------------------SLRLKGQMVY-------MENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMR-----LLDEEMR-RTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDP-----STGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGP-NYKIIERGEIDVKGKGTMGTYWLEERE 596          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGL-TEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDE--FRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQG--SQAIE---CFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRV--EGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQ 2012
            M+G L   + E + +  G EKWE++ ++ G+ +  F    +Y E + ++L  +A  +       F + MG  +   +      + + +LG    +F+  LD LH      YP+   P F  + E  +   + LHY SKR          +R + +  + KE+ I ++ E    D  HV + +  D   F +        +A T++    + H     H   ++    M FG D +     RS  + L     M++  + +  +I A    D       F +  I + + N+ +  + +  + + F  +NE + +H +   P +                           +   KG ++Y       + N  +I++L +P + +L ++   G++I+D+  HD ++ L      Q++E      +   K   LE  +      + D+++     E  + M+P+ +AD ++ G+      +M+ + SILF D+V F  I    +P EV++MLN ++  FD+L E + V+KV+ IGDAY++V+G P    NHAER+  MAL M+ A      P     + G  +  R+G+HSG V+ G++G  + R+ + G+ V  ASRMES  I  +VH+SES    + P  +++  RG I+++GKG + TY L+E +
Sbjct:    1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENE--TKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEILFDTVHVTFQLTFDNRAFTLAS------LAMTRE----EKHLPISAHVLFEIFPFCMVFGADMV----VRSIGNSL-----MVILPELLGKKITA--WFDLVRPLIAFKFQTILNRTNNIFEL-VTVDPVTERFDVQNEDLLQHEDGSEPEK---------------------------SLRLKGQMVY-------MENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMR-----LLDEEMR-RTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDP-----STGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGP-NYKIIERGEIDVKGKGTMGTYWLEERE 596          

Query:  840 LLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGM-IVQHASP---TEVLTMLNDLHDKFDRLAEVH---DVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL-----KPFKFEVESRGNIEIRGK 1976
            L+  + FC +FP+H++FD  M + QAG  +  ++    +EN S+ + +E + P     NF NI  +I   +VL+TR   ++     +   L  +GQM+ +     IL+ C P V NLD + + G++ISD+P HD  + L   S+  E   + T   + L   L    + +  +    D     ++++P+ +A+ ++  + V  K Y + +++F  +V FG     +  P    +++ MLN+L+  FD L +     +V+KV+ +GD Y+ VSG+P    +HA+ +A++AL M+  ++        GSN    V   IG+HSG+V+ GVIG  V R+ + G  V + SR E+ G+P R+++SE  Y  L     +   F +E RG + ++GK
Sbjct:  327 LISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRP-HLQLNFENILSHINTIYVLQTRQGAMSSRHEQR--FLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTD--RLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAK----NVKMGSN---PVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGK 705          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKR--LGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHE 557
            M+G +   ++ +VL H G E WE + K+  + +   F    IYD+ +   LI  A+ I N   +   E+ G+T+          + +++LG +  +F+QNLD LH      YP    P FR   +   L    LHYYS+R  L  +V  +++ +   +   E++I I+    E
Sbjct:    1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCTEKDGEL---LLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGE 170          

Query:  243 VMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEF-RDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLF---QGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL---KPFKFEVESR 1952
            ++GE       +    ++ R LG    EF+ +LD ++   + K  + D+     DT      +  L + S+R  ++ ++   L+ + + ++K +++I+I     +  RY  ++S++ D  +      PT V++T                               +P    RS+ S                    + L +++S FC +FP+H I +  + L Q G     + + +  D     T + +   P      F +I +    P ++    NN  G        L  +GQM+     + +L++ SP++  LD +  +G+ ISDIP HD T+ +    + ++A +  +RR +K   ++  +      +  +        H   + P  IA+ +  G  ++ K Y + +ILF D+V F  I   A+P  V++ML  L+  FD   +  DV+KV+ IGDAY + SG+       A ++A MAL M+ A         + ++ G ++  RIGLH+G V+ GV+GR + R+ + G +V +A++ ES     ++++S +    L   + F+FE++ R
Sbjct:  116 LLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYD--VLKLQEEDV----TDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKT-------------------------------IPETVQRSNSSN------------------ASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGL--NNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDK---IKNSIEEANSAVTKERKKNVSLLH--LIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACS------KHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPR 624          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEK-LDHLRMEFGDDALPVNRFRSDRSKLKASTRML---VFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHR---FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK-FEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMG 2039
            M+G +   +K +V+   G E WEN+    G+ E F    IYD+ +  +L+ EA  + +   E+  ++ GE + +          +R LGG+  EFI+NLD LH+     Y   + P FR+  E     ++ LHYYS R+ L  +V  ++  + K  F  E+ + I++++ ED+R     HV++ ++      ++E      AQT++N   +   +EV+  KE+ +  ++  + +  L   R RS   +L  S  ML      ++  P  P +L ++   FC+ FP+HI+FDS + +K  G+ +Q  V   +     + ++  +VHP    FN  +I+K+I    VLKTR   L          L  RGQM+ + + + ++YLCSP + +L  +E+ G+H++DI  HD T+ L   +Q     IE   +   K + L          I   +L+ +  +     +AM+P  +A+ +K G+RVE   ++ C+ILF D+V F  I     P +++ MLN ++ +FDRL  +H+V+KV+ IGDAY++V G+P P   HAER+A  AL M  A+R    P       G  +  R+GLH+G V+ GV+G  + R+ + G+ V  ASRMESHG+PD +H+S   +S +K    FE+  RG IE++GKG + TY L +N   + + IMG
Sbjct:    1 MYGFINTCLKSLVIERFGEETWENLRLMAGVQETFMTYEIYDDIITLRLVQEACKMLDVSSEVVLKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEAMNAPSFRV--ERMDDGRILLHYYSDRKGLYHIVPGIIEAVAKDFFDSEVTMTILNQSEEDERTGKKEHVVFHMV------QKEKVTKRKAQTRQNNSEE-EILEVKKDKEETMRRMKARYANLQL-CPRKRSP-WELVRSIVMLGQGNLRQSFTPSYPKTLWIEEQAFCNAFPFHIVFDSDLVVKHTGVNIQKFVPGLQTAGIRLDEYFTIVHP-EVIFNIQSIKKFINSQFVLKTRREMLP-EVQQNQPTLKLRGQMMWMESLNCMIYLCSPKLRSLQELEERGLHLADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELR---------ILSRNLEIEKQKSEKLLYAMLPTHVANQLKEGKRVEAGEFKVCTILFSDVVTFTNICAACEPIQIVNMLNAMYSRFDRLTSIHNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGMRIAAREVTNPIT-----GQPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFEMAERGEIEVKGKGLMRTYFLLKNLQKSDEQIMG 654          

Query:  828 PASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLF---QGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDG-DLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASR--LTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL---KPFKFEVESR 1952
            P  L +  S FC  FP+H++  S+M + Q G  ++   +       + +   ELV P R   +F NI   ++ P  ++TR +  + +   K  V+  +GQM+ L   + I++L SP V  L+ +   G+H+SDIP HD T+ +    + ++A +  K+R +K   L+  L    Q + ++     DL    +++ P  +A  +  G  V+ K + + ++LF D+V F  +    +P +V++MLN+L+ +FD    + DV+K++ IGDAY +  G+   I +HA+ IA MAL M+  S   LTP         G  +  RIG+HSG V+ GV+G  + R+ + G NV +AS+ ES   P  +++S + Y  L   + F F   SR
Sbjct:  211 PLDLRIGLSTFCRAFPFHLVLGSNMEVLQVGEGLRKQAKTDPHRTLTFSNSFELVSP-RIPCSFQNILLRLSTPFTIRTRPDGSSLDCREK--VMELKGQMLHLPESNSIMFLGSPRVDRLEELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDK---LKATLEKTHQALEEEKRRTVDL---LYSIFPGDVAQRLWQGLPVQAKKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHRKIDSHAKPIALMALKMMELSEEVLTP--------DGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLLRDDRSFTFIPRSR 577          

Query:  858 FCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-----KFEVESRGNIEIRGK 1976
            FC  FP+H++FD  + L Q G  +  ++ + +    +++    LV P   DF+F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA+ I  +AL M+  +       +        V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y  L+       +F +E RG + ++GK
Sbjct:  213 FCKAFPFHLMFDKDLMLTQCGNAIFRVLPQLQPGVCNLSSVFSLVRP-HIDFSFHGILSHINTVFVLRSKEGLLNVETAENEDELTGT---EISCLRLKGQMISLPETENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQHTLRALEDEKKKTD--RLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASAEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLPEPCTHHAKSICHLALDMMEIAGQVKVDED-------PVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLQSVENADPQFHLEYRGPVTMKGK 595          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLK--RLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHED 560
            M+G +   ++ +VL + G + WE++ +  ++ +   F    IY++     L+  A  +         ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+    N + LHYYS+RE L  +V  +++ + + +   EI++++I    E+
Sbjct:    1 MYGFVNHALELLVLRNYGPDVWEDIKREAQVDVEGQFLVRIIYEDAKTYDLVAAASKVLKMDAGGILQMFGKMFFEFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRC-TDAEKGNNLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIEMKVIQPKSEE 173          

Query:  858 FCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-----KFEVESRGNIEIRGK 1976
            FC  FP+H++FD  + L Q G  +  ++ + +    +++    LV P   DF+F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA+ I  +AL M+  +       +        V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y  L+       +F +E RG + ++GK
Sbjct:  207 FCKAFPFHLMFDKDLMLTQCGNAIFRVLPQLQPGVCNLSSVFSLVRP-HIDFSFHGILSHINTVFVLRSKEGLLNVETAENEDELTGT---EISCLRLKGQMISLPETENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQHTLRALEDEKKKTD--RLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASAEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLPEPCTHHAKSICHLALDMMEIAGQVKVDED-------PVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLQSVENADPQFHLEYRGPVTMKGK 589          

Query:   78 VVLNHGGNEKWENVLK--RLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHED 560
            +VL + G + WE++ +  ++ +   F    IY++     L+  A  +         ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+    N + LHYYS+RE L  +V  +++ + + +   EI++++I    E+
Sbjct:    6 LVLRNYGPDVWEDIKREAQVDVEGQFLVRIIYEDAKTYDLVAAASKVLKMDAGGILQMFGKMFFEFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRC-TDAEKGNNLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIEMKVIQPKSEE 167          

Query:  825 IPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRD--ENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTK---YLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELK 1925
            IP SLL         FP+HI+ D  M L Q G  ++  +   RD     +  +H  +V P     +F +I   +    +L+ + +  +   +P G  +  +GQMI +S    +L+L SP V  L+ +   G+++SDIP H+  +    + + ++A +  K+R  K    +  L    Q + ++       E  F + P  +A  +  G  V+ K + + ++LF D+V F  I    +P +V+ ML++L+ +FD      DV+KV+ IGDAY +  G+      HA +IA MAL M+  S     P      +G  +  RIG+HSG V+ GV+G  + R+ + G NV +A++ ES  +P ++++S + Y  LK
Sbjct:  279 IPLSLLYST------FPFHILLDQEMGLLQIGDGLRRRLGRCRDGQRRPAFNEHFAIVSP-EIRASFQDILTMLNTQFLLRVKQHGASSADSP-GKHMDLKGQMIFMSEMSALLFLGSPCVDKLEELTGRGLYLSDIPIHNALRDVVLVGEQTKAQDGLKKRLGKA---KAALEQAHQALEEEK--RRTVELLFTIFPGNVAQRLWQGLPVQAKKFDHVTVLFSDIVGFTAICSRCTPMQVVNMLSELYTRFDHHCGELDVYKVETIGDAYCVAGGLHKESPTHAVQIALMALKMMELSDEVTTP------MGEVIRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFESCSLPRKINVSPTTYRLLK 631          

Query:  297 VRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILD-EFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLK-ASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDT 2063
            +R LGG  YEFI NLD LH+     Y + + P FR++  G     M LHYYS R  L  +V  ++  +    FK EI + IIS++ E++R     H+++ V     F  +    P +V++  KN          E+   K    + +     +  N +   R  ++    RML   +  +P  P  L +D   FC   P+HI+FD  + +KQAG+ +Q IV   +     + ++   VHP        N++K+I    V +T+   +  ++  +  +L  RGQMI +     +LYLCSP +  L  +E+  MHISDI  HDVT+ L   +Q        +N+ +  +  L    + + ++    +L    +AM+P+ +A+ +K G+RVE   ++ C+ILF D+V F  I     P +++ MLN ++ +FDRL  VHDV+KV+ IGDAY++V G+P P+ +HAER+A  AL M+  ++    P N     G  +  R+GLHSG V+ GV+G  + R+ + G+ V  ASRMESHG+P+++H+S ++Y  LK   FE+  RG I+++GKGR+ TY L  N +  ++ I+G+  +  D+
Sbjct:    8 LRTLGGDLYEFIANLDALHSYLSLSYQEMNAPSFRVEMNGDG--SMHLHYYSDRRGLCHIVPGIMGAVAMDFFKTEISMEIISQSDEEERTGKKEHIVFLVTQKPAFPPKCPTKPPLVSRGIKNKS-------FENPYNKYRDRKNQVSVCPVKKNHWAMIRGIVQLGKGRML---RGFRPVYPKDLCVDVETFCKGLPFHIVFDEELRIKQAGVSIQKIVPGLQTTGIRLDQYFSTVHP-EVTLTISNVRKFINSQFVFRTKREMMPESWRDRP-MLELRGQMIWMEKLECMLYLCSPLLRTLHELEERQMHISDIAPHDVTRDLILLNQQRLAEMELSNQLERKKEELRILSKHLEEEKKKTEL--LLYAMLPKHVANQLKEGKRVEAGEFKECTILFSDVVTFTNICAQCEPIQIVFMLNSMYLRFDRLTTVHDVYKVETIGDAYMVVGGVPVPVSSHAERVANFALGMILMAKQVKNPVN-----GNPIQIRVGLHSGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPNKIHISPTVYRYLKGKNFEMTERGEIDVKGKGRMRTYFLIRNSSAKENEILGQAIKETDS 581          

Query:  825 IPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLF---QGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDG-DLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASR--LTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELK 1925
            IP+ L +  S FC  FP+H++FD +M + Q G  ++ +++    +        E+V P +    F  +   ++ P V++ + +  T  F  K  V+  +GQMI +     IL+L SP V  LD +   G+H+SDIP HD T+ +    + ++A +  K+R +K   L+  L    Q + ++     DL    +++ P  +A  +  G+ V+ + + + ++LF D+V F  +    +P +V++MLN+L+ +FD      D++KV+ IGDAY + +G+     +HA+ IA MAL M+  S   LTP         G  +  RIG+HSG V+ GV+G  + R+ + G NV +AS+ ES   P R+++S + Y  LK
Sbjct:  292 IPSDLRISISTFCRAFPFHLMFDPNMLILQLGEGLRKLIKCEVHKTMQFHDSFEIVSP-KISCTFEQVLLRLSTPFVIRNKPDAPT--FENKDKVMEVKGQMIYVPESSSILFLGSPRVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDK---LKATLEKTHQALEEEKKKTVDL---LYSIFPGDVAQQLWEGKSVQARKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGLLRQSNSHAKPIALMALKMMELSEEVLTP--------DGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK 647          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEV-----EHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L++ A  + N       ++ G  +            +R+LG +  EF+Q+  ++         KA   LF ++   A      LH +    Y      S  RC      K                       ++  +  E+E    +V    K    Q+H  E+     + + E+ DH +    +       F  D+ + + +          + RI          FC  FP+HI+FD  + + Q G  +  ++ + +  N ++     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ +FD L +  +   V+KV+ +GD Y+ VSGIP P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F ++ RG + ++GK
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVSAATKVLNLNAGDILQMFGNMFFVFCQESGYDTILRVLGSNVREFLQHFIYIIDK------KACFLLFPINNLDA------LHDHLGTIYPGMRAPSF-RCTDAEKGKG----------------------LILHYYSEREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKDTREEDFYEDQDRFEENGTQ-------ESRI------SPYTFCKAFPFHIMFDRDLFVTQCGNAIYRVLPQLQPGNCNLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKSESEDELTGT---EISCLRLKGQMIYLPEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQHTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLQYRGPVSMKGK 613          

Query:  858 FCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            FC  FP+HI+FD  + + Q G  +  ++ + +  N ++     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ +FD L +  +   V+KV+ +GD Y+ VSGIP P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F ++ RG + ++GK
Sbjct:  197 FCKAFPFHIMFDRDLFVTQCGNAIYRVLPQLQPGNCNLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKSESEDELTGT---EISCLRLKGQMIYLPEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQHTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLQYRGPVSMKGK 579          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHED 560
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L++ A  + N       ++ G  +            +R+LG +  EF+Q           + P     +F    +G  L    LHYYS+RE L  +V  +++ + + +   EID+++I + +E+
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVSAATKVLNLNAGDILQMFGNMFFVFCQESGYDTILRVLGSNVREFLQ----------VRKPF----IFYYCFKGKGL---ILHYYSEREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEE 157          

Query:  858 FCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            FC  FP+HI+FD  + + Q G  +  ++ + +  N ++     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ +FD L +  +   V+KV+ +GD Y+ VSGIP P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F ++ RG + ++GK
Sbjct:  213 FCKAFPFHIMFDRDLFVTQCGNAIYRVLPQLQPGNCNLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKSESEDELTGT---EISCLRLKGQMIYLPEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQHTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLQYRGPVSMKGK 595          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHED 560
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L++ A  + N       ++ G  +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVSAATKVLNLNAGDILQMFGNMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEE 173          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRML---VFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDD 2060
            M+G +   ++ +V    G E WE +     + + F    +YD+ +  +LI EA    +   E   ++ GE +          + +R LGG+  EFI+NLD LH+     Y + + P FR+  EG +   MRLHYYS R  L  +V  ++  + K  F  ++ + I+  N E +R     HV++ V+    R         +   K N      N++ + +  +   LR +    ++PV       S +  ++ +L         +P  P  L ++   FC+ FP+H++FD ++ +KQAG+ +Q  V     +   + ++  +VHP +  FN  +I K+I    +LKTR   +   +  +   L  RGQMI + +   ++++CSP + +L  +E+  MH+SDI  HD T+ L   +Q     +E   +   K + L     SN   I     +  L    +AM+P  +A+ +K G++V    +  C+ILF D+V F  I     P +++ MLN ++ KFDRL  +HDV+KV+ IGDAY++V G+P P+ +HA+R+A  AL M  +++    P       G  +  R+G+H+G V+ GV+G  + R+ + G+ V  ASRMESHG+P++VHLS + +  L+   FE+ +RG IE++GKG++ TY L  N    +  IMG    L D
Sbjct:   82 MYGFINTCLQSLVTEKFGEETWEKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRV--EGGADGAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKARRQ--------IRGAKVNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVFPERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQKYVPGILTQKFGLDEYFSIVHP-QVTFNISSICKFINSQFILKTRREMMPEAWKSQP-TLKLRGQMIWMESLKCMVFMCSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVL--SNHLAIEKKKTETLL----YAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVT-----GEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALAD 741          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRML---VFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDD 2060
            M+G +   ++ +V    G E WE +     + + F    +YD+ +  +LI EA    +   E   ++ GE +          + +R LGG+  EFI+NLD LH+     Y + + P FR+  EG +   MRLHYYS R  L  +V  ++  + K  F  ++ + I+  N E +R     HV++ V+               A+ +  G   L    +  ++  L          ++PV       S +  ++ +L         +P  P  L ++   FC+ FP+H++FD ++ +KQAG+ +Q  V     +   + ++  +VHP +  FN  +I K+I    +LKTR   +   +  +   L  RGQMI + +   ++++CSP + +L  +E+  MH+SDI  HD T+ L   +Q     +E   +   K + L     SN   I     +  L    +AM+P  +A+ +K G++V    +  C+ILF D+V F  I     P +++ MLN ++ KFDRL  +HDV+KV+ IGDAY++V G+P P+ +HA+R+A  AL M  +++    P       G  +  R+G+H+G V+ GV+G  + R+ + G+ V  ASRMESHG+P++VHLS + +  L+   FE+ +RG IE++GKG++ TY L  N    +  IMG    L D
Sbjct:   82 MYGFINTCLQSLVTEKFGEETWEKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRV--EGGADGAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQK-------------ARRQIRGAKSLQGTLLRKKERYL----------SIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVFPERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQKYVPGILTQKFGLDEYFSIVHP-QVTFNISSICKFINSQFILKTRREMMPEAWKSQP-TLKLRGQMIWMESLKCMVFMCSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVL--SNHLAIEKKKTETLL----YAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVT-----GEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALAD 726          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK-----FEVESRGNIEIRGK 1976
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D ++ + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y  L   +     F +E RG + ++GK
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG---AEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPLFHLEHRGPVSMKGK 595          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL 1922
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D ++ + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y +L
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG---AEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRKL 572          

Query:  822 RIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKH---LELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLF---QGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDG-DLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASR--LTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELK---PFKFEVESR 1952
            ++PA L +  + FC  FP+H++FDS+M + Q G  ++   ++ R +     K     E+V P   +  F  +   ++ P V++T+          +  V+  +GQMI +     IL+L SP V  LD +   G+H+SDIP HD T+ +    + ++A +  K+R +K   L+  L    Q + ++     DL    +++ P  +A  +  GQ+V+ + + + ++LF D+V F  I    +P +V++MLN+L+ +FD    + D++KV+ IGDAY + SG+      HA+ IA MAL M+  S   LTP         G  +  RIG+HSG V+ GV+G  + R+ + G NV +AS+ ES   P R+++S + Y  LK    F F   SR
Sbjct:  309 QVPADLRISINTFCRAFPFHLMFDSNMVVLQLGEGLR---KQLRYDTHRALKFEDCFEIVSP-MINATFDRVLLRLSTPFVIRTKPE--ASGTENEDKVMEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDK---LKATLERTHQALEEEKKKTVDL---LYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTP--------DGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREDSFTFIPRSR 677          

Query:  297 VRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYK-----NVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERK 2048
            +R LGG+  EFI+NLD LH+     Y + + P FR++  GA   KM LHYYS R  L  +V  ++  + K  F  ++ + I+  N E +R     HV++ ++    R  ++  P  +  ++           +E  +E L    ++  +  L V+     +S       +++F K       +P  P  L ++   FC+ FP+HI+FD S+ +KQA + +Q  V   + +N  + ++  ++HP +  FN F+I+++I    VLKTR   +   +  +   L  +GQMI + +   ++YLCSP + +L  +E+  MH+SDI  +D T+ L   +Q     IE   +   K + L+    S    I     +  L    +AM+P+ +A+ ++ G++V    +++C+ILF D+V F  I     P +++ +LN ++ KFDRL  VH V+KV+ IGDAY++V G+P PI NHA+R+A  AL M  +++    P       G  +  R+G+H+G V+  V+G  + R+ + G+ V  ASRMESHG+P++VHLS + Y  LK   F++  RG IE++GKGR+ TY L +N    +D IMG  K
Sbjct:    8 LRTLGGNLMEFIENLDALHSYLALSYQEMNAPSFRVE-RGAD-GKMFLHYYSDRSGLCHIVPGIIEAVAKDFFDIDVIMDILDMNEEVERTGKKEHVVFLIVQKAHRKMRKTKPKRLQDSQG----------MERDQEALQAAFLKMKEKYLNVSACPVKKSHWDVVRSIVMFGKGHLMNTFEPIYPERLWIEEKTFCNAFPFHIVFDESLQVKQARVNIQKYVPGLQTQNIQLDEYFSIIHP-QVTFNIFSIRRFINSQFVLKTRREMMPVAWQSRT-TLKLQGQMIWMESMWCMVYLCSPKLRSLQELEELNMHLSDIAPNDTTRDLILLNQQRLAEIELSNQLERKKEELQVL--SKHLAIEKKKTETLL----YAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTACEPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMRISAKEVTNPVT-----GEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQGFKIIERGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSK 579          

Query:  228 ELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYK-----NVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKG----GVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTN 2120
            E   ++ GE +          + +R LGG+  EFI+NLD LH+     Y + + P FR++ EGA    M LHYYS R  L  +V  ++  + K  F  ++ + I+  N E +R     HV++ V+    R         +   K +      + + + +  +   LRM+     +PV     ++S   A    ++F K       +P  P  L ++   FCD FP+HI+FD ++ +KQAG+ +Q  V     +  ++ ++  ++HP +  FN  +I K+I    VLKTR   +     PK      +L  RGQMI + +   ++++CSP V +L  +E+  MH+SDI  HD T+ L   +Q     +E   +   K + L     SN   I     +  L    +AM+P  +A+ +K G++V    +  C+ILF D+V F  I     P +++ MLN ++ KFDRL  VHDV+KV+ IGDAY++V G+P P+ +HA+R+A  AL M  +++    P       G  +  R+G+H+G V+ GV+G  + R+ + G+ V  ASRMESHG+P +VHLS + +  LK   FE+  RG IE++GKG++ TY L +N    +D IMG      D   +    ++ ++    P N
Sbjct:    2 EAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVE-EGAD-GAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQ--------IRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPV--CPGEKSHSTAVRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFSIIHP-QVTFNISSICKFINSQFVLKTRKEMM-----PKARKSQPMLKLRGQMIWMESLRCMIFMCSPNVRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVL--SNHLAIEKKKTETLL----YAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVT-----GEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRN 620          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENV--LKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLH--TTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK----FEVESRGNIEIRGKGRLYTYLLKEN 2009
            MFG +    +++V    G + WE +  + +  L  + +  H Y++    +L+N   N+     E  +E  G       +     + +R +      F+ +LD LH     +    K   P FR D +      + LHYYSKR  L  +V+ ++R + + ++  E+ +++     E           LD F  E  V   ++ Q +     Q  ++       K D                    S++  ST +   Y+           + +SDF   FPYHI FD  + ++  G  ++        +   +T  LELVHP    F++ +I+ Y     V + +   ++  N   +   +  +G M+ +     ILY+CS  V  +  + +  +H+SD+  HD T+ +   +Q+           +     L    Q +  +    D  E    ++P  +AD +++G+ ++ K + +C++LF D+V F  I    +P +V+T+LNDL+ +FDRL  +HD +KV+ IGDAY+IV G+P    NHAER+  +++ ML  S+L   P  +       +  R+G+H G V+ GV+G  + R+ + G+ V +A++MES+GI  ++H+SE+   +L   K    +    RGN EIRGKG +YTY L+ N
Sbjct:    1 MFGWIHESFRQLVTRKYGKDIWEKIVHMSKFELGTESEIAHYYNDDETLRLVNSMANVIGIPIEEIWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHVVYKTKLRGPSFRCDVQADG--TLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQERKQEH----------LDAFVTEHVV--FVITQIENANSTQPKSI-----SSKAD--------------------SQIDLSTGI---YE-----------ISSSDFSLAFPYHICFDPDLFVEHFGNFIKKTFPNAMRQETRVTDLLELVHP-EVPFSYESIKYYKNSLFVFRLKGLGDIVHNANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERNLHLSDMQRHDGTRDVIMLNQSRMSQVELNRTLEETTKKLKKMAQELEIEKQKTD--ELLCELMPASVADSLRSGKAMDAKEFADCTLLFTDIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVLNISIGMLMESKLVLSPITHKP-----IKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSET--GKLNGLKANPSYVFIDRGNTEIRGKGMMYTYFLERN 601          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQET---HIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADI--PLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQM-QLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNL------------------------TGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSE-LKPFKFEVESRGNIEIRGKGRLYTYLL 2000
            MFG +   ++++V+   G + W  VL+R G  E+ +E    H Y +     L++    +    ++  +E+ G       +     + VR +  +   F+ NLD LH        KA++  P FR   E      + LHY++ R  L  +V+ +++ + K VF   +DI ++ +       H+                         NGE       VE      +H+     +   P  R  SD S   A T +   +  +   I  +L +   DF    PYH + D S  L Q G ++   I  E       I +  E+  P +   +F NI  +I    VL+ + + L                          N   +G  L  +GQM+ LS K  I+YLCSPYV +++ + Q GM ++ +P HD T+ L   +Q     +E   +     + LE    ++   +     D  L +    M+PR IA  + +G+ +E   Y   +++FCDL  F  I+    P  ++ +LN++  K DR+  +  V+KV+ + D+Y+ VSGIP     HAE +  +AL M++ +R    P N         L RIGLHSG +I GV+G  + R+ + GE V +AS+MES G+  ++  S   YS+ ++  +FE   RG I ++G+G + TY L
Sbjct:    1 MFGFIHESIRQLVIRKYGEDVWLQVLERSGF-ENGKENIVNHYYSDTDTYVLVDSVSIVLKVTKDQIWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFR--CEENPDGTLMLHYFTGRPGLYHIVKGVVKEVAKLVFN--LDISLVVQGRTQRSVHM------------------------NNGE------RVE------EHVIFLIKNVEEP--RRDSDTSTTSALTSVEPDFGEI---IDDNLKVSLQDFSRALPYHFVLDESCRLVQCGDELYNHIPNELLQPGTPILRIFEINRP-QIPLDFENICNFINAVFVLQVKTSPLRKKHMNAMTKEEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETM--THELEVERQKTDSILKD----MLPRKIAKQLLSGEHLEPCEYE-ATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYTSEHAENMCHVALGMMWEARSVMDPVN-----KTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFL 628          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED--FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTR-----------HNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGK 1976
            M+G +   ++ +V+ + G E WE++ K   L E+  F    IYD+     L+  A  + N       ++ G+ +            +R+LG +  EF+QNLD LH      YP    P FR  T+      + LHYYS+RE L  +V  +++ + + +   EID+++I + +E+  +         +F +E                      E E ++E       +F +D   ++RF  + ++              + RI       A  F  IF      D  + + Q G  +  ++ + +  N S+     LV P   D +F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LNDL+ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA  I  +AL M+  +             G  V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y      E    +F +E RG + ++GK
Sbjct:    1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRC-TDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDH--------TQFLIE----------------------EKESKEE-------DFYED---LDRFEENGTQ--------------ESRISPYTFCKAFPFHIIF------DRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRP-HIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGT---EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQLTLRALEDEKKKTD--TLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVD-------GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMTPENSDPQFHLEHRGPVSMKGK 595          

Query:   48 FGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALP-VNRFRSD----RSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHR---FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSESAM 2144
            +G +   +K +V++  G E W+ +    G+ + F    IYD+ +  +L+ EA  + +   E+  ++ GE + +          +R LGG+  EFI+NLD LH+     Y + + P FR+  E     KM LHYYS R+ L  +V  ++  + K  F  E+ + I+ ++ ED+R     HV++ V+        E   T   + ++ G       E + ++     L+M+     LP   R R+     RS +K     L+   +  P  P  L ++   FC+ FP+HI+FD ++ +KQ G+ +Q  V   +  N  + ++  + HP +  F+  +I+K+I    VLK R   L  +   +  VL  RGQM+ +++   +LYLCSP + +L  +E+ G+HI+DI  HD T+ L   +Q     IE   +   K + L          I    L+ +  +     +AM+PR +A+++K G++VE   ++ C+ILF D+V F  I     P +++ MLN ++ KFDRL  +HDV+KV+ IGDAY++V G+P P   HAER+A  AL M  A+R    P       G  +  R+GLH+G V+ GV+G  + R+ + G+ V  ASRMESHGIPD +HLS +  S LK   FEV  RG I+++GKG + TY L +N  ++++ IMG++     T  L +  D  Q       +RPGS+ ++
Sbjct:    1 YGFINTCLKSLVIDKFGEETWDKLRMLAGVQDTFMTYEIYDDTLTVRLVQEACKMLDVSSEVVLKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYQEMNAPSFRV--EKTEDGKMLLHYYSDRKGLCHIVPGIIEAVAKDFFNSEVHMTILDQSEEDERMGKREHVVFLVV--------EKTSTFKKKAQQMGGANSAAQEQDRKQRDETFLKMKTRYTNLPPCPRKRAPWEIVRSIVKFGRGSLI--NSFTPSYPPKLWIEEQTFCNAFPFHIVFDENLKVKQTGVNIQKFVPGLQTMNIRLDEYFSITHP-QVPFSIESIRKFINSQFVLKARCEMLPKS-AQQQSVLKLRGQMVWMASLGCMLYLCSPKLRSLQELEERGLHIADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELR---------ILSHHLEVEKKKTETLLYAMLPRHVANLLKEGKKVEAGEFKVCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSIHDVYKVETIGDAYMVVGGVPVPTETHAERVANFALGMRIAAREVTNPIT-----GKPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGIPDHIHLSPTTQSALKGKSFEVIERGEIQVKGKGMMTTYFLLKNLHLSEEEIMGKK-----TEELCVYNDSQQETQ---ESRPGSKKSI 679          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSV-----ILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHR---FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDT 2063
            M+G +   +K +V++  G E WE +    G+ + F    +Y + +  +L+ EA  + +   ++  +  GE +            +R LGG+ ++FI+NLD LH+     Y + + P FR+  E      M LHYYS R  L  +V  ++  + K  F  EI + I+++  E++R     H+++ V       ++ R +    P  +A +++  E QL+  ++E    ++     +     +  N + + R  +K     L+  +  +P  P +L +D   FC+ FP+HI+FD  + +KQAG+ +Q IV   +     + ++  ++HP    F   +++K+I    VL+T+ + +  ++  +  +L  RGQM+ + +   +LYL SP + +L  +E+  MHISDI  HDVT+ L   +Q     +E   +   K + L          I    L+ +  +     +AM+PR +A+ +K G++VE   ++ C++LF D+V F  I     P +++ MLN ++ KFDRL  VHDV+KV+ IGDAY++V G+P P+ +HAER+A  AL M+ A+R    P       G  +  R+GLH+G  + GV+G  + R+ + G+ V  ASRMESHG+P+R+HLS S +  LK   F+V  RG IE++GKG+++TY L  N       IMG   R  D+
Sbjct:    1 MYGFINTCLKSLVIDKFGEETWEKLRHEAGVQDTFMTFEVYKDDITMRLVEEACKLLDVAPDVVLKQFGEYFFEFCKRSGYDHMLRTLGGNLFDFIENLDALHSYLSLSYQEMNAPSFRV--EKIEDGTMHLHYYSDRRGLCHIVPGIIGAVAKDFFNSEITMEIVNQMEEEERTGKKEHIVFLVTQKPAFTNKRRSKLSATPQYLANSRRQSEKQLNKEDIEKSMHRIRSKDNQTAACPMKKNHWETVRGIVKLGKGKLL--RGFEPVYPETLCIDLKTFCNAFPFHIVFDEELRVKQAGVNIQKIVPGLQTMGIHLDQYFTIIHP-EVTFTISSVRKFINSQFVLRTKRDMMPESWR-RCPMLELRGQMVWMDSLQSMLYLASPLLRSLQELEERRMHISDIAPHDVTRDLILLNQQRLAEMELSNQLERKKEELR---------ILSKHLEEEKKKTETLLYAMLPRHVANQLKEGKKVEAGEFKECTVLFSDVVTFTTICSECEPIQIVFMLNSMYLKFDRLTTVHDVYKVETIGDAYMVVGGVPIPVSSHAERVANFALGMIIAAREVTNPVT-----GDPIQIRVGLHTGPALAGVVGEKMPRYCLFGDTVNTASRMESHGVPNRIHLSPSAHRALKDKGFKVIDRGEIEVKGKGKMHTYFLAGNLTATDSEIMGRPLRESDS 669          

Query:  792 MLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERK 2048
            M + Y  + P IP +L +   DFC++FPYH +FD +M LKQ+GIQ+Q I+ +FR  N  I K+L+L+HP    F F +++  +  PHV+K   N LT     +   +Y RGQMI+L     IL++CSP V +L+ IE+ GM +S+IP HDVTKY         C  +   KGDW + FLG +     +D+ D +  +H   +        +      EG+ Y+NC ILFCD+V F  IV  + P EVL MLN++H++FDRL  VHDV K+D +GDAY+IVSGI   I   +ERIA +ALAM+  S+    PY+YGSN G R L RIGL+ G++IGG+IG    +FT+MG++VV AS+MESHGIPDR+H++ ++Y EL    +++E RG IEIRGKGR +TY L  N  ++ + ++G+ +
Sbjct:    1 MNIMYSRMLPTIPKALSIGPKDFCELFPYHFVFDQAMLLKQSGIQIQAIIPDFRRINVDIRKYLQLIHPTHEQFTFESVENLLCSPHVMKVIDNKLTTT-ANQDDEIYLRGQMIKLMENQCILFMCSPMVSSLNDIERKGMKMSEIPNHDVTKYF--------CSFQTIGKGDWSDKFLGRDNNTSGEDNSDVETYDHFATLAGASTMSGLINNSLREGRKYKNCYILFCDIVHFSTIVTSSGPNEVLDMLNNIHNEFDRLTRVHDVQKIDSVGDAYLIVSGILDHINQRSERIANIALAMILISKTIKSPYDYGSNFGKRALIRIGLNCGEIIGGIIGSANPKFTVMGDSVVTASKMESHGIPDRIHITAAMYRELASSHYDMEERGCIEIRGKGRQFTYFLNRNLDVSDNALLGKTR 410          

Query:   48 FGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRME---FGDDALPVNRFRSD--RSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRD 2093
            +G +   ++ +V+   G E WE +     + + F    +YD+ +  +LI EA  +     E   ++ GE +          + +R LGG+  EFI+NLD LH+     Y + + P FR+  E A+  KM LHYYS R  L  +V  ++  +GK  F  ++ + I+  N E +R     HV++ ++    R  ++  P+ +  ++ N  +Q        +  K   LRM+       A PV +   D  RS +      LV     +P  P  L ++   FC+ FP+HI+FD S+ +KQAG+ +Q  V   + +   + ++  ++HP +  F+ F+I K+I    VLKTR   L   +  +   L  RGQMI + +   ++YLCSP + +L  +E+H M++SDI  HD T+ L   +Q     IE   +   K + L     S    I     +  L    +AM+P  +A+ +K G++V    ++ C+ILF D+V F  I     P +++ MLN ++ KFDRL  VH+V+KV+ IGDAY++V G+P PI +HA+R+A  AL M  +++    P       G  +  R+G+H+G V+ GV+G  + R+ + G+ V  ASRMESHG+PD+VHLS + Y  L+   FE+  RG IE++GKG++ TY L +N    KD IMG       T PL     RD
Sbjct:   22 YGFINTCLQSLVIEKFGEETWEKLKASAEVQDAFMTYTVYDDTITIKLIQEACKVLGVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRV--ERAADGKMLLHYYSDRSGLCHIVPGIIEAVGKDFFNLDVTMDILDMNKEVERTGKKEHVVFLIVQKARRKMRKAKPSRLQDSQDNQSDQ--------EALKAAFLRMKEKYLSVSACPVKKSHWDVVRSIVMFGKGHLV--NTFEPIYPERLWIEEKTFCNAFPFHIVFDESLRIKQAGVTIQKYVPGLQTQKIRLDEYFSIIHP-QVTFDIFSICKFINSQFVLKTRREMLPEAWKSQP-TLKLRGQMIWMESTRCMMYLCSPKLRSLQELEEHKMYLSDIAPHDTTRDLILLNQQRLAEIELSNQLERKKEELRVL--SQHLAIEKKKTETLL----YAMLPEHVANQLKEGKKVAAGEFKTCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHEVYKVETIGDAYMVVGGVPVPIGSHAQRVANFALGMRISAKEVMNPVT-----GEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPDKVHLSPTAYRALENQGFEIIERGEIEVKGKGKMTTYFLIQNLNATKDEIMGR-----PTTPLDHKEARD 686          

Query:   48 FGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFR-MEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYK-----NVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMG 2039
            +G + + ++ +V    G E WE +     + + F    +YD+ +  +LI+EA  I     E   ++ GE +          + +R LGG+  EFI+NLD LH+     Y + + P FR+  E A   KM LHYYS R  L  +V  ++  + K  F  ++ + I+  + E +R     HV++ ++    R M +  P  +      +GE Q     +   KE+   +       A P+      +S       +++F K       +P  P  L +    FC  FP+H++FD S+ +KQAG+ +Q  V   + +   + ++  ++HP +  FN F+I K+I C  VL+TR   L   +  +   L  RGQMI + +    LYLCSP + +L  +E+HGMH+SDI  HD T+ L   +Q     +E  ++   K + L+    S    I     +  L    +AM+P  +A+ +K G++V    ++ C+ILF D+V F  I     P +++ MLN ++ KFDRL  VH+V+KV+ IGDAY++V G+P P  +HA+R+A  AL M ++++    P       G  +  R+G+H+G V+ GV+G  + R+ + G+ V  ASRMESHG+PD+VHLS + Y  L+   FE+  RG IE++GKG++ TY L +N    +D IMG
Sbjct:    1 YGFINICLQSLVTEKFGEETWEQLKAATEVQDAFMTYTVYDDAITIKLIHEACKILGVSMEAILKLFGEYFFKFCKVSGYDRMLRTLGGNLTEFIENLDTLHSYLALSYQEMNAPSFRV--ERAVDGKMLLHYYSDRNGLCHIVPGIIEAVAKDFFALDVTMEILDRSEEVERTGKKEHVVFLIVQKVCRKMRKAAPDRLRGSQDAHGECQARQAALLRMKERYSII------SACPMK-----KSPWGVVKSIVMFGKEHLVNTFEPVYPERLWIGEETFCHAFPFHVVFDESLRIKQAGVNIQRFVPGLQTQKARLDEYFSIIHP-QVTFNIFSICKFINCQFVLRTRRGMLPETWRSRPR-LELRGQMIRMESTRCFLYLCSPKLRSLQELEEHGMHLSDIAPHDATRDLILLNQQRLAEMELSRQLERKKEELQVL--SRHLAIEKKKTETLL----YAMLPEHVANQLKEGKKVAAGEFKTCTILFSDVVTFTNICAACEPIQIVHMLNSMYSKFDRLTGVHEVYKVETIGDAYMVVGGVPVPSGSHAQRVANFALGMRFSAKEVMNPVT-----GEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPDKVHLSPTAYRALENQGFEIIERGEIEVKGKGKMTTYFLIQNLKATEDEIMG 652          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKL-DHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHR---FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSE 2135
            M+G +   ++ +V+   G E WE +     + + F    IYD+ +  +L+ EA  + +   E+  ++ GE + +          +R LGG+  EFI+NLD LH+     Y + + P FR+  E  +  +  LHYYS R+ L  +V  ++  + K  F  ++ + I+ +  E +R     HVI+ +             T  ++  K  E  L+  +   +++ + DH++  F                               PR P  L ++   FC+ FP+HI+FD ++ +K  G+ +Q  V   +     + ++  +VHP     N  +I+K+I    VLKTR   L  +   +  +L  RGQM+ + + H ++YLCSP + +L  +E+ G+H++DI  HD T+ L   +Q     IE   +   K + L          I   +L+ +  +     +AM+PR +A+ +K G++V+   ++ C+ILF D+V F  I     P +++ MLN ++ +FDRL  VHDV+KV+ IGDAY++V G+P P   HAER+A  AL M  A+R    P       G  +  R+GLH+G V+ GV+G  + R+ + G+ V  ASRMESHG+PD +HLS   YS LK   FE+  RG I+++GKG + TY L +N  +++D IMG  K     Y      D  Q     P N+   E
Sbjct:    1 MYGFINTCLRTLVVEKFGEETWEKLRLLAEVQDTFMTYEIYDDVITLRLVQEACKMLDVSSEVVLKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEEMNAPSFRV--ERTNDGRTLLHYYSDRKGLHYIVPGIIEAVAKDFFGSKVTMTILEQPKEQERTGKREHVIFLM-------------TQTSEGAKGEEAHLNGGDGTVERKVMSDHIQHSFC------------------------------PRYPKRLWIEEQAFCNAFPFHIVFDQNLVVKHTGVNIQKFVPGLQKTGCRLDEYFSVVHP-EVTLNIHSIKKFINSQFVLKTRREMLPESLQNQT-MLKLRGQMVWMESLHCMVYLCSPKLRSLQELEERGLHLADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELR---------ILSRNLEVEKKKTETLLYAMLPRHVANQLKEGKKVDAGEFKVCTILFSDVVTFTNICAACEPIQIVHMLNSMYSRFDRLTNVHDVYKVETIGDAYMVVGGVPIPKDTHAERVANFALGMRIAAREVTNPIT-----GKPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHLSPFTYSALKDKMFEIRERGEIQVKGKGLMDTYFLIQNLQLSEDQIMGRGKEETCVY-----RDNLQEEEHGPDNKTAEE 643          

Query:   48 FGHLPLIVKEVVLNHGGNEKWENVLKRLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRY----HVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKL-DHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHR---FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSE 2135
            +G +   ++ +V+   G E WE +     + + F    IYD+ +  +L+ EA  + +   E+  ++ GE + +          +R LGG+  EFI+NLD LH+     Y + + P FR+  E  +  +  LHYYS R+ L  +V  ++  + K  F  ++ + I+ +  E +R     HVI+ +             T  ++  K  E  L+  +   +++ + DH++  F                               PR P  L ++   FC+ FP+HI+FD ++ +K  G+ +Q  V   +     + ++  +VHP     N  +I+K+I    VLKTR   L  +   +  +L  RGQM+ + + H ++YLCSP + +L  +E+ G+H++DI  HD T+ L   +Q     IE   +   K + L          I   +L+ +  +     +AM+PR +A+ +K G++V+   ++ C+ILF D+V F  I     P +++ MLN ++ +FDRL  VHDV+KV+ IGDAY++V G+P P   HAER+A  AL M  A+R    P       G  +  R+GLH+G V+ GV+G  + R+ + G+ V  ASRMESHG+PD +HLS   YS LK   FE+  RG I+++GKG + TY L +N  +++D IMG  K     Y      D  Q     P N+   E
Sbjct:    8 YGFINTCLRTLVVEKFGEETWEKLRLLAEVQDTFMTYEIYDDVITLRLVQEACKMLDVSSEVVLKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEEMNAPSFRV--ERTNDGRTLLHYYSDRKGLHYIVPGIIEAVAKDFFGSKVTMTILEQPKEQERTGKREHVIFLM-------------TQTSEGAKGEEAHLNGGDGTVERKVMSDHIQHSFC------------------------------PRYPKRLWIEEQAFCNAFPFHIVFDQNLVVKHTGVNIQKFVPGLQKTGCRLDEYFSVVHP-EVTLNIHSIKKFINSQFVLKTRREMLPESLQNQT-MLKLRGQMVWMESLHCMVYLCSPKLRSLQELEERGLHLADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELR---------ILSRNLEVEKKKTETLLYAMLPRHVANQLKEGKKVDAGEFKVCTILFSDVVTFTNICAACEPIQIVHMLNSMYSRFDRLTNVHDVYKVETIGDAYMVVGGVPIPKDTHAERVANFALGMRIAAREVTNPIT-----GKPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHLSPFTYSALKDKMFEIRERGEIQVKGKGLMDTYFLIQNLQLSEDQIMGRGKEETCVY-----RDNLQEEEHGPDNKTAEE 649          

Query:  297 VRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVE-VEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNF--TPKGGVLYFRGQMIELSNKHLILYL---CSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKR 2051
            +R LG + +EFI+NLD LH      Y + + P FR+  E  S   M LHYYS R  L  +V  ++  + K  F   I+++I+++  E +R      V+   F + Q  P  + +++  +   Q        H K    H+  + GD+    N F S +             +  +P  P  L +D   FC+ FP+HI+FD  + ++QAG+ +Q IV   +     + ++  ++HP    F   +I+K+I    VL+TR   +  ++  TP          M+E     L        SP + +L  +E+  M++SDI  HD T++L   +Q        +++ +  +  L    Q +  +    +     +AM+P+ +A+ +K G++VE   ++ C+ILF D+V F  I     P +++ MLN ++ KFDRL  VH+V+KV+ IGDAY++V G+P P+ +H ER+A  AL M+ AS+    P       G  +  R+GLHSG V+ GV+G  + R+ + G+ V  ASRMESHG+PD++H+S ++Y  L+   F++E RG I+++GKGR+ TY L +N    +  IMG   R
Sbjct:   27 MRTLGANLFEFIENLDALHGYLSISYKEMNAPSFRV--EKNSDGTMLLHYYSDRRGLCHIVPGIIGAVAKDFFNSRIEMKIVNQMEEVERTGKKEHVV---FLITQHFPDKICSKSTSSPSQQTQKPSGCRHNKV---HINKQVGDE---YNLFFSGK-----------LLRGFEPVYPNELCIDLKTFCNAFPFHIVFDEELRVRQAGVAVQKIVPGLQTMGIQLDQYFTILHP-EVTFTIASIRKFINSHFVLQTRREMMPESWKDTP----------MLECCGWPLSAACSTRASPLLRSLQELEERRMYLSDIAPHDATRHLILLNQQRLAEMELSSQLERKKEELRQLSQHLEQEKQKTE--NLLYAMLPKHVANQLKEGKKVEAGEFKECTILFSDVVTFTTICSQCEPIQIVIMLNSMYLKFDRLTTVHNVYKVETIGDAYMVVGGVPIPVSSHGERVANFALGMIIASKEVTNPIT-----GGPIQIRVGLHSGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGLPDKIHVSPNVYYALRDKGFQLEERGEIDVKGKGRMRTYFLVKNLRATESEIMGRWTR 577          

Query:  807 KNVKP--RIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENE--SITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLF---QGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASR--LTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL---KPFKFEVESR 1952
            KN  P  R P+ L +  S FC   P+H++   SM + Q G  ++ + +  R  +   S +   +LV P R   +F NI   +A P  ++TR +  T   +    V+  +GQMI L   + I++L SP V  L+ +   G+H+SDIP HD T+ +    + ++A +  K+R +K   L+  L    Q + ++       E  +++ P G+A  +  G  V+ K + + ++LF D+V F  +    +P +V++MLN+L+ +FD    V DV+K++ IGDAY + +G+     +HA  IA MAL M+  S   LTP            +  RIG+HSG V+ GV+G  + R+ + G NV +AS+ ES   P  V++S + Y  L   + F F   SR
Sbjct:    2 KNSHPLSRSPSDLRIGLSTFCRACPFHLVIGPSMEVLQVGEGLRQVGEGLRKPHRTLSFSDSFQLVSP-RIPCSFQNILLRLATPFTIRTRPDASTKKSSLCFSVMELKGQMIHLPESNSIMFLGSPRVDRLEELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDK---LKATLERTHQALEEEKRRTV--ELLYSIFPGGVAQRLWQGLPVQAKKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGVLDVYKIETIGDAYCVAAGLHKKCESHARPIALMALKMMELSEEVLTP--------DAKPIQLRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLASKFESGSKPRCVNVSPTTYQLLRDDRSFSFIPRSR 381          

Query:  297 VRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVE-----HQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-----KFEVESRGNIEIRGK 1976
            +R+LG +  EF+QNLD LH      YP    P FR  T+    N + LHYYS+RE L                 ++I I II                              VAQ       Q+H  E+E      + E+ DH++    +       F  D    + +          + RI          FC  FP+H++FD  + L Q G  +  ++ + +    +++    LV P   DF+F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q    F+        LE         I  D L   +      ++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ KFD L +      V+KV+ +GD Y+ VSG+P P  +HA+ I  +AL M+  +                V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y  L+       +F +E RG I ++GK
Sbjct:   19 LRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRC-TDAEKGNNLILHYYSEREGL-----------------QDIVIGIIK----------------------------TVAQ-------QIHGTEIEMKVIQQKSEECDHIKFLIEEKDSEEEAFYEDLDGFEENGTQ-------ETRI------SPYTFCKAFPFHLMFDKDLMLTQCGNAIFRVLPQLQPGVCNLSSVFSLVRP-HIDFSFHGILSHINTVFVLRSKEGLLNVEMAECEDELTGT---EISCLRLKGQMISLPETENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ----FREEYKLTQELE---------ILTDLLPHPIITPTTPLLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASAEGAIKIVNLLNDIYTKFDILTDSRKNPYVYKVETVGDKYMTVSGLPEPCTHHAQSICHLALDMMEIAGQVKVDEE-------PVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLQSVENADPQFNLEYRGPITMKGK 517          

Query:  900 MNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA----IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMG 2039
            + +KQAG+ +Q  V   +  +  + ++  + HP    F   +I+K+I    VLKTR   L      +  +L  RGQM+ +     +LYLCSP + +L+ +E+  +HISDI  HD T+ L   +Q     +E   +   K + L   L  N Q +     +  L    +AM+P  +A+ +K G++VE   ++ C+ILF D+V F  I     P +++ MLN ++ +FDRL  VH+V+KV+ IGDAY++V G+P P+ +HAER+A  AL M+ A+R    P       G+ +  R+G+HSG V+ GV+G  + R+ + G+ V  ASRMESHG+P R+HLS S    L+  +F+VE RG IE++GKGR+ TY L  N+++ +  I+G
Sbjct:    1 LRVKQAGVNIQKFVPGLQTMDIRLDEYFTIGHP-EVTFTIESIRKFINSQFVLKTRREMLPEARRSQP-MLDLRGQMVWMEGSRSMLYLCSPLLRSLEELEERQLHISDIAPHDATRDLILLNQQRLAEMELSTQLERKKEELR-VLSKNLQ-VEKKKTEALL----YAMLPHHVANQLKEGKKVEAGEFKVCTILFSDVVTFTNICAVCEPIQIVHMLNAMYMRFDRLTTVHNVYKVETIGDAYMVVGGVPIPVPSHAERVANFALGMVLAAREVTNPVT-----GSAIQIRVGIHSGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGLPGRIHLSPSTREALQGKEFDVEERGEIEVKGKGRMSTYFLLGNRSVGEQEILG 371          

Query: 1389 FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN---HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK-FEVESRGNIEIRGKGRLYTYLL 2000
            + ++P  +A+ +K G+ V+ + + + +I F D+V F  +   ++P +V+T+LNDL+  FD + +  DV+KV+ IGDAY++VSG+  P+RN   +A+ IA+M+LA+L A +     +        ++  RIG+H+G V  GV+G  + RF + G+ V  ASRMES+G   ++H+S++    L  F  F +E RG++E++GKG++ TY L
Sbjct:  616 YQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL--PVRNGKLNAKEIARMSLALLDAVK----TFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWL 817          

Query: 1389 FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN---HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-KFEVESRGNIEIRGKGRLYTY-LLKEN 2009
            + ++P  +A+ +K G+ V  + + + +I   D+V F  +   ++P +V+  LNDL+  FD + +  DV+KV+ IGDAY++VSG+  P+ N   HA  +A+MALA+L A R     ++       R+L RIG+H+G V  GV+G  + R+ + G+ V  ASRME+ G   R+HLS +  + L  +  F V+  G+++I+GKG + TY LL EN
Sbjct:  299 YQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL--PVHNGTRHAIEVARMALALLSAVRC----FHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504          

Query: 1389 FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN-HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-KFEVESRGNIEIRGKGRLYTYLLK 2003
            ++M+P+ IAD ++ G+  + + Y + ++ F D+V F  +   ++P EV+  LN L+  FD + + +DV+KV+ IGDAY++VSG+PT   N HA   A MAL ++   +    P+     +  R     G+H+G V+ GV+G  + R+ + G+ V  ASRMES     ++  S S  S L+    + +  RG + ++GKG + T+ L+
Sbjct:  293 YSMLPKQIADDLRQGRVTKAQSYASATVFFSDIVGFTQLSSSSTPYEVVDFLNKLYTSFDGIIDNYDVYKVETIGDAYMVVSGVPTENHNQHAVETANMALDLVNVCQAFVIPHKPEMQLKIRA----GIHTGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSEALKIQCSPSTSSILQQIGSYLLSCRGTVTVKGKGEMITWWLE 495          

Query: 1389 FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN---HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK--FEVESRGNIEIR 1970
            + ++P+ +   +K+   V+ +++   +I F D+V F  I +H  P EV+ +LNDL+ +FD + + HDV+KV+ IGDAY++VSG+P   RN   HA  IA +AL +L         ++     G  V  RIG+HSG    GV+G  + R+ + G+ V  ASRMES G P R+H+S+S    L   +   +   RG IE++
Sbjct:  246 YQLLPKTVVQALKSVGSVQPELFEEVTIYFSDIVGFTTICKHCEPMEVVCLLNDLYKEFDSIVDSHDVYKVETIGDAYMLVSGLPK--RNGCHHAMEIANVALDILSFMG----SFHIQHLPGLPVWVRIGIHSGKCAAGVVGNKMPRYCLFGDTVNTASRMESTGYPYRIHVSQSTVDTLNAQQSGHQFTCRGIIELK 438          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTED---FQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFR-MDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQM-QLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHN--NLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQA-------IECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHAS--PTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLS 1901
            M+G +   + ++V+   G E W++++K+ G+  D   +    IYD+    +L+  A   T    +   EV G  + A        + +++LG +  +F+ NLD LH      YP  + P FR  +T+  +L    LHYYSKR  LS +V  L++ I K + + E+++  I ++ +++  HV +++   E   +      +  QT  +G    H  E E  K                    RS  + +K+ T         K R      ++   FC  FP+H++FD  +++KQAG+ + +++ ++  ++    T    +  P R +F+F  +  +I    V+ T+     L  N       L  +GQM+ + +   +L+LCSP V N+D++ + G++ SDIP HD T+ L   S A       +E  +  +N    +E  L  + +    DDL        ++++P+ +A  ++  Q V  + Y+  +ILF D+V F  +  +    P +++ MLN L+  FD L+ ++DV+KV+ IGDAY++V G+P P  +HA+R+A M L M+ A+ +   P +        +  RIG+H+G V+ GV+G+ + R+ + G  V +A++MES   P R+++S
Sbjct:    1 MYGFIHCALADLVIGKFGEEAWKDIIKKAGVELDGGSYLIHKIYDDEETLRLVGAACEATGLELDTVLEVFGAHFFAYCEKSGYDRILKVLGRNLRDFLCNLDALHDHLATIYPGMEAPSFRCTETDNGTL---LLHYYSKRPGLSYIVIGLVKAIAKQLLETEVNV-TIHQDIDEENDHVTFAI--REAENKHSSGSKLGLQTFASG----HETEKEANK--------------------RSKDASVKSETH--------KKR-----EMNLLSFCKAFPFHVMFDRKLHIKQAGLSLTRIMTKQKLNDTLKFTDLFRISRP-RMEFSFQAVISHINTVFVVTTKAGAVQLPDNIESTDASLRLKGQMLYVPDSDCLLFLCSPRVKNMDSLREKGLYFSDIPVHDATRDLLFLSHARRAERELVEKLEETSNNLKKVESKLIEHKKRT--DDL-------LYSILPKEVAAKLRLNQSVPAESYKTVTILFSDIVGFTALCSNDKIVPMDIVKMLNRLYTYFDMLSGMNDVYKVETIGDAYMVVGGLPHPCEDHADRVASMGLGMMEAADVVLSPVDREP-----LKIRIGIHTGPVMAGVVGKKMPRYCLFGNTVTLANKMESGTQPGRINIS 577          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKR----LGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLT------------GNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQH-ASPTEVLTMLNDLHDKFDRLAEVH-DVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSEL--KPF-KFEVESRGNIEIRGKGR-LYTYLLKENQAINKD 2027
            M+G +   ++++V+   G + W+ +L++    LG + +F E  IYD++    L+  A ++    +    E  G+ +    +       +R LGG+  +F  +LD LH   +  YP    P FR      ++ K+ L Y S+R  L  MV  L++ +   ++  ++++ + S + +D  + + Y                               V  +HQ    D ++     D   + R   + S +  S+R                 +  + FC   P+H +FD  M + QAGI +  ++   R     +T   E + P      F NI +YI   +V+KT+   L             GN       + FRGQM+ L   + I++L SP V NLD + + G+++SDIP HD T+ L   S+      + + + + L   L    + + ++    D     ++++P  +A+ ++  + V    Y   +I+F  +V F         P E++ MLN+++ +FD+L + + D++KV+ +GD Y+ VSG+PT    HA  IA +AL M+  S+            G ++   IG+HSG+V+ GV+G+   R+ + G  V + SR E+ G+  ++++SE  Y  L  +P  +F  + RG + ++GK   + TY+L+ N     D
Sbjct:    1 MYGFVNRALQDLVIQGYGPDVWKEILEKANLDLGDSREFNERRIYDDQNTSDLLIVAEDVIGLSKNAILERFGDAFFEHCIGSGYDSMIRSLGGNLMDFFNSLDGLHEQLLLLYPGMRPPSFRAKQHNINM-KLELVYTSERSGLEYMVVGLVKTVASKLYGIQVNVELASMSSKDQSWAMFY-------------------------------VLPQHQ----DEMKYILPTDT-TLERTMKELSIMTLSSR-----------------IGTAAFCRACPFHAVFDQRMVIYQAGISLCRVLPAVRVGKSKLTDIFESIRPP-IKLTFDNILQYINKVYVIKTKSGLLDSASLSTVSEDDYGNLESPS--MRFRGQMMYLPECNSIMFLASPSVVNLDGLNEKGLYMSDIPIHDATRDLILLSEQHNAEFKLSQRLEILTDKLQQTSRELENEQQLND--RLLYSILPASVANDLRLRKPVNANKYEIVTIMFSGIVDFTNYCNKIKEPMEIVEMLNEVYTEFDQLTDSNDDIYKVETVGDKYMAVSGLPTRCDKHALNIANLALDMIDISKGMKAK-------GIQLQVTIGIHSGEVVAGVVGQKKPRYCLFGNTVNLTSRTETTGLKGKINVSEYAYRCLLVQPHEQFVFKKRGPVVMKGKKEPMITYILQRNDKYQPD 617          

Query:   48 FGHLPLIVKEVVLNHGGNEKWENVLK--RLGLTEDFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRII-SENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLT---GNFTPKGGV---------LYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAE--VHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLY-----SELKPFKFEVESRGNIEIRGKGR-LYTYLLKEN 2009
            +G +   ++ +V+ + G  KWE + +   L +   F +  IYD+ M   L+  A  + +       E  GE +          + +++LGG+  +FI NLD LH    + YP    P FR+ ++  S   + LHYYS+R+ L  +V  +++ + + +   E+ + ++  + ++ D    +   I D  R                        + + Q +  D ++  F           S+  K+  +T                       FC  FP+H++F+  + + QAG  +  +V      +  +++  EL+ P +  F +  I  +I    VL+TR   L+    N   K G          L  +GQM+ +     +++LCSP V NL+ +   G+++SDIP HD TK L   S+  +     T + + L   L      + +     D  +  ++++P  +A+ ++  + V+ +     ++LF  +V F  I +++ P E++ +LN+++ KFD L +  ++DV+KV+ +GD Y+ VSG+P     HA  I  MAL M + ++          + G ++  +IG+HSG+V+ GV+G    R+ + G  V + SR E+ G P +V+++E  Y      E +   F  E RG + ++G+   + TYLL  +
Sbjct:  100 YGFVNHALELLVVRNFGVAKWEEIKRAAELEIEGHFLQRIIYDDVMTYSLVGAATRVLDIETSAILEKFGEMFFDFCQESGYDRILQVLGGTLRDFIGNLDALHDHLGSIYPGMRAPSFRV-SDRESDGALILHYYSERDGLEPIVVGIVKTVARKLLNTEVSVEVVKGKEYDGDDVQFVIKEISDRGR------------------------DCDSQVKNYDPIKDSFQ---------LSNEPKISPAT-----------------------FCKAFPFHLMFNRDLKVTQAGESVSRVVPSLTPGDADMSEIFELIRP-QLRFTYEAIIAHINTVFVLRTREGKLSKPANNMCNKNGCCKLCWDSLPLRLKGQMVYIPESDNMIFLCSPSVGNLEDLADVGLYLSDIPLHDATKDLILLSEQFKAEYVLTQQLEILTDKLRQTHNALAEKKQLTD--QLLYSVLPPSVANELRHNRPVQAERAEMVTLLFSGIVDFAQICKNSKPMEIVMLLNNIYTKFDMLTDPSINDVYKVETVGDKYMAVSGLPERCAFHARSICNMALDMKHVTQSI-------IHKGDKIQIKIGIHSGEVVAGVVGHKTPRYCLFGNTVNLTSRTETTGAPGQVNITEFTYRCLLEPECQDPSFVFERRGPVAMKGRQEPMVTYLLTRD 709          

Query: 1392 AMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN---HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-KFEVESRGNIEIRGKGRLYTYLL 2000
            AM PR +A+ +K G++V  + + + ++ F D+V F  +    SP  V  MLND++  FD   E +DV+KV+ IGDAY++VSG+  P+RN   HA+ I +M+L ++   RLT          G +++ R+G+H+G  + GV+G  + R+ + G+ V  ASRM++ GIP +VH+SE+ Y  L  F  F +E RG +E++GKG + TY L
Sbjct:    8 AMFPRSVAETLKLGEKVPSEHFDSVTVFFSDIVDFTNMCAMISPMSVTQMLNDVYSVFDDHIEKYDVYKVETIGDAYMVVSGL--PLRNGTSHADEIGRMSLDLV---RLTETTTLDSVPKGKKLMVRVGIHTGPCVSGVVGYKMPRYCLFGDTVNTASRMQTTGIPQKVHISETTYDLLTKFNTFHMEYRGTLEVKGKGLMRTYWL 209          

Query:  834 SLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLI---------------VQEFRDEN-ESITKHLELVHPGRCDFNFFNIQK--------YIACPHV------LKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQG------SQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRV--EGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLL 2000
            SL +    F ++FP+H+++D SM +   G  ++ +               ++ F D + ES+  H  +V   +      +++K         + CP +      +   H+N   N T     ++ +GQM+ +     + YL +P   +   +      +      DV     +       S+ ++C ++           L  + + + ++ L  D     + M+P+ +AD ++ G+      + + N +ILF D+V F  I    +P +V+TMLN ++  FD+L+E H+V+KV+ IGDAY++VSGIP   + HAE +A MAL ML A      P   G N   R+  RIG+H+G V+ GV+G  + R+ + G+ V  ASRMES G+   +H+SE     L    + ++ RG+++I+GKG + TY L
Sbjct:  209 SLSIHIDVFYEVFPFHVVYDKSMTITSVGSSLEAVLPNLVGCKITDEFSLIRPFLDFSWESVFVHTNVVFELQSRSKALSMRKNGKVQNGLLMGCPIMDALGEGVNGNHDN-NHNVTEFDSRIHLKGQMMYIDEWKAMAYLATPINISTLMLINFTFFLQTYLDVDVILLFLRKEIRIILSKDVKCMQKSAK--------LEESMRELDNEKLRTD--ALLYQMIPKTVADRLRKGEPALNTCETFSNVTILFSDVVGFTTICSLIAPMQVVTMLNCMYTTFDKLSEKHNVYKVETIGDAYMVVSGIPERTKYHAEHVADMALNMLSAMPEIEDP--AGLNDHLRI--RIGIHTGTVVAGVVGLKMPRYCLFGDTVNTASRMESTGLAMAIHVSEDTQKFLAKANYALKQRGSMDIKGKGGMKTYWL 620          

Query:   45 MFGHLPLIVKEVVLNHGGNEKWENVLKRLGLTE-DFQETHIYDERMGEQLINEAINITNTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILD 596
            ++G L   V  ++ +  G + W  + +  G+ +  F   +IY + + ++L++ A  IT   R    E  G  + + +      + +R+LG    +F+  LD LH      YPK   P F    E  +   M+LHY S R+     V   +R +GK  + ++I++ ++ ++   + +  +  +  D
Sbjct:    2 VYGLLIENVSSLLTSRYGEDTWHKIRENAGVQQHTFAIHNIYSDSIFQRLVSSAEEITGEDRNSLLESTGALFVSFIGQFGYDKILRILGRHIRDFLNGLDNLHEFMRFTYPKLKAPSFHCSEE--TERGMKLHYRSSRKGFLYYVVGQIREVGKMFYDQQIEVEVLEQHESKEGFVAVMQLYFD 184          

Query:  273 VSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVE-----HQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRH-----------NNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYL-FQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIV-QHAS---PTEVLTMLNDLHDKFDRLAEVHD---VFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPF-----KFEVESRGNIEIRGK 1976
            V   N  SVR     + E+  NLD LH      YP    P FR  T+    N + LHYYS+RE L                 ++I I II                              VAQ       Q+H  E+E      + E+ DH++    +       F  D    + +          + RI          FC  FP+H++FD  + L Q G  +  ++ + +  +  +     LV P   DF+F  I  +I    VL+++            + LTG    +   L  +GQMI L     IL+LCSP V NLD + + G+++SDIP HD T+ L   G Q  E +K  T + + L   L    + + D+    D     ++++P  +A+ ++  + V  K Y N +ILF  +V F     +HAS     +++ +LND++ +FD L +      V+KV+ +GD Y+ VSG+P P  +HA+ I  +AL M+  +                V   IG+H+G+V+ GVIG+ + R+ + G  V + SR E+ G   ++++SE  Y  L+       +F++E RG I ++GK
Sbjct:   40 VHDHNLGSVR-----WTEWFDNLDALHDHLGTIYPGMRAPSFRC-TDAEKGNNLILHYYSEREGL-----------------QDIVIGIIK----------------------------TVAQ-------QIHGTEIEMKVIQQKSEECDHIKFLIEEKDSEEEAFNEDLDGFEENGTQ-------ETRI------SPYTFCKAFPFHLMFDKDLMLTQCGNAIYRVLPQLQPGSCILPSVFSLVRP-HIDFSFHGILSHINTVFVLRSKEGLLNVETVENEDELTG---VEISCLRLKGQMIYLPEAENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK-LTQELEILTDRLQHTLRALEDEKKKTD--RLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSKHASAEGAIKIVNLLNDVYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLPEPCTHHAKSICHLALDMMEIAGQVKVD-------DESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLQCAENADPQFQLEYRGPITMKGK 551          

Query:  828 PASLLLDASDFCDIFPYHIIFDSSMNLKQ--AGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGVLYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLF---QGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDG-DLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASR--LTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELK---PFKFEVESRGNI 1961
            P+ L +  + FC  FP+H++    M L Q   G++ Q  ++  R  + S     E+V P + + +F  I   +A P  ++TR ++       K  V+  +GQMI +     +++L SP V  L+ +   G+++SDIP HD T+ +    + ++A +  K+R +K   L+  L    Q + ++     DL    +++ P  +A  +  GQ V  + + + ++LF D+V F  +  H +P +V++MLN+L+ +FD    + DV+K++ IGDAY +  G+   + +HA+ IA MAL M+  S   LTP         G  +  RIG+H+G V+ GV+G  + R+ + G NV +AS+ ES   P  +++S + Y  LK    F F   SR ++
Sbjct:  383 PSDLRIGLATFCRAFPFHLVLGPHMELLQLGEGLRRQARIEPHR--SFSFRDCFEIVSP-KMEPSFQGILLRLASPFTIRTRPDSTQAGTKEK--VMELKGQMIHVPESCSLMFLGSPRVDKLEELMGRGLYLSDIPIHDATRDVILVGEQAKAQDGLKKRMDK---LKATLERTHQALEEEKRRTVDL---LYSIFPGDVAQKLWQGQPVPARKFDDVTMLFSDIVGFTAVCAHCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHKKVDSHAKPIAHMALKMMELSDEVLTP--------DGKPIKLRIGIHTGSVLAGVVGVKMPRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLLKDDRSFSFVPRSRMDL 752          

Query: 1392 AMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN-HAERIAKMALAMLYASRLTPCPY--NYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELK-PFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVI----MGERKR 2051
            +M+PR IAD + +G+ VE + Y   +I F D+V F  +   +S  EV+T LNDL+  FD + +++DV+KV+ IGDAY++ SG+P    N HA  I+ MAL  L A ++   P+  N G  I      RIG+HSG V+ GV+G  + R+ + G+ V  ASRMES+ +P ++H+S+S    L     FE+E RG IE++GKG   TY L +    N  ++     GE +R
Sbjct:  737 SMLPRYIADQLMSGKSVEPQSYDMVTIFFSDIVGFTSMCSVSSAMEVVTFLNDLYSLFDDIIKMYDVYKVETIGDAYMVASGLPISNGNKHALEISTMALHFLAAIKIFKIPHMPNEGLAI------RIGIHSGPVVAGVVGTTMPRYCLFGDTVNTASRMESNSLPLKIHISQSTADILVLAGSFEMEERGEIEMKGKGFQKTYWLLKKTGFNPPLVAPNTFGEERR 958          

Query: 1389 FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN---HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK-FEVESRGNIEIRGKGRLYTYLLK 2003
            + ++P  +AD +K G+ V+ + + + +I F D+V F  +   ++P +V+T+LNDL+  FD + +  DV+KV+ IGDAY++VSG+  P+RN   H   +A+MALA+L A +     +        ++  RIG+HSG V  GV+G  + R+ + G+ V  ASRMES G   ++H+SE+    L+ F  F+++ RG IE++GKG + TY L+
Sbjct:  846 YQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL--PVRNGKLHGREVARMALALLDAVK----SFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQ 1048          

Query: 1389 FAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRN---HAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFK-FEVESRGNIEIRGKGRLYTYLLK 2003
            + ++P  +AD +K G+ V+ + + + +I F D+V F  +   ++P +V+T+LNDL+  FD + +  DV+KV+ IGDAY++VSG+  P+RN   H   +A+MALA+L A +     +        ++  RIG+HSG V  GV+G  + R+ + G+ V  ASRMES G   ++H+SE+    L+ F  F+++ RG IE++GKG + TY L+
Sbjct:  787 YQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL--PVRNGKLHGREVARMALALLDAVK----SFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQ 989          

Query:  216 NTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGV---LYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 2192
            +TRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRI               P  ++ D+S                                      +F +I  Y    H++     NL      + G+   L  +GQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIE        GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDR+QRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK
Sbjct:  249 DTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRI---------------PASLLLDAS--------------------------------------DFCDIFPY----HIIFDSSMNLK-----QAGIQMQLIVQGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIE--------GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRNQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 840          

Query:  246 MGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKHLELVHPGRCDFNFFNIQKYIACPHVLKTRHNNLTGNFTPKGGV---LYFRGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 2192
            MGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRI               P  ++ D+S                                      +F +I  Y    H++     NL      + G+   L  +GQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIE        GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDR+QRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK
Sbjct:    1 MGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRI---------------PASLLLDAS--------------------------------------DFCDIFPY----HIIFDSSMNLK-----QAGIQMQLIVQGQMIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIE--------GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRNQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 582          

Query: 1128 MIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIECFKRRTNKGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 2192
            MIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIE        GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDR+QRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK
Sbjct:    1 MIELSNKHLILYLCSPYVHNLDAIEQHGMHISDIPTHDVTKYLFQGSQAIE--------GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRNQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 347          

Query: 1302 KGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 2192
            +GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDR+QRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK
Sbjct:  520 RGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRNQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 816          

Query:  216 NTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKH 980
            +TRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLS     LLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQ+   E  +  K+
Sbjct:  256 DTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLS-----LLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQDVLKEGLTSMKY 505          

Query: 1302 KGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRDQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 2192
            +GDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDR+QRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK
Sbjct:  518 RGDWLEGFLGSNGQPIFDDDLDGDLGEHRFAMVPRGIADVMKTGQRVEGKMYRNCSILFCDLVQFGMIVQHASPTEVLTMLNDLHDKFDRLAEVHDVFKVDVIGDAYVIVSGIPTPIRNHAERIAKMALAMLYASRLTPCPYNYGSNIGARVLARIGLHSGDVIGGVIGRPVHRFTIMGENVVMASRMESHGIPDRVHLSESLYSELKPFKFEVESRGNIEIRGKGRLYTYLLKENQAINKDVIMGERKRLDDTYPLAMSPDRNQRVSFAPTNRPGSESAMKVHQPRQLRPKSGRNK 814          

Query:  216 NTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQEFRDENESITKH 980
            +TRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQ+   E  +  K+
Sbjct:  249 DTRRELFFEVMGETYCAIMVSKENSQSVRLLGGSFYEFIQNLDFLHTTAMAKYPKADIPLFRMDTEGASLNKMRLHYYSKREYLSRMVESLLRCIGKTVFKKEIDIRIISENHEDDRYHVIYSVILDEFRMEQEVPPTMVAQTKKNGENQLHNVEVEHQKEKLDHLRMEFGDDALPVNRFRSDRSKLKASTRMLVFYKNVKPRIPASLLLDASDFCDIFPYHIIFDSSMNLKQAGIQMQLIVQDVLKEGLTSMKY 503