cAMP-dependent protein kinase catalytic subunit

Overview
NamecAMP-dependent protein kinase catalytic subunit
Smed IDSMED30034681
Length (bp)1341
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of cAMP-dependent protein kinase catalytic subunit (SMED30034681) t-SNE clustered cells

Violin plots show distribution of expression levels for cAMP-dependent protein kinase catalytic subunit (SMED30034681) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of cAMP-dependent protein kinase catalytic subunit (SMED30034681) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for cAMP-dependent protein kinase catalytic subunit (SMED30034681) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30034681

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 4 cellSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30034681SMESG000016651.1 dd_Smed_v4_911_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Human
Match: PRKACA (protein kinase cAMP-activated catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9380])

HSP 1 Score: 514.227 bits (1323), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T  LD+FE +KTLGTGSFGRV+L  HK++  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Human
Match: PRKACA (protein kinase cAMP-activated catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9380])

HSP 1 Score: 514.227 bits (1323), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T  LD+FE +KTLGTGSFGRV+L  HK++  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Human
Match: PRKACB (protein kinase cAMP-activated catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9381])

HSP 1 Score: 510.76 bits (1314), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+  +  S VK FL +AK++F  K+++P Q    L++FE  KTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+Y+FKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIK H WF + DW + +++++ APFIPK RG GDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNAATAKKGSEVES-VKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Human
Match: PRKACA (protein kinase cAMP-activated catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9380])

HSP 1 Score: 508.064 bits (1307), Expect = 2.939e-180
Identity = 239/340 (70.29%), Postives = 300/340 (88.24%), Query Frame = 2
Query:  152 DNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            ++S VK FL +AK++F  K++ P Q T  LD+FE +KTLGTGSFGRV+L  HK++  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    4 NSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Human
Match: PRKACA (protein kinase cAMP-activated catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9380])

HSP 1 Score: 508.064 bits (1307), Expect = 2.939e-180
Identity = 239/340 (70.29%), Postives = 300/340 (88.24%), Query Frame = 2
Query:  152 DNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            ++S VK FL +AK++F  K++ P Q T  LD+FE +KTLGTGSFGRV+L  HK++  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    4 NSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Celegans
Match: kin-1 (cAMP-dependent protein kinase catalytic subunit [Source:UniProtKB/Swiss-Prot;Acc:P21137])

HSP 1 Score: 526.554 bits (1355), Expect = 0.000e+0
Identity = 248/344 (72.09%), Postives = 306/344 (88.95%), Query Frame = 2
Query:  140 RDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +D K+++ +K FL++A+++F  ++++P Q T  LD+F+ +KTLGTGSFGRV+L  HK+S  Y+A+K+LDK K+VKLKQVEHTLNEKRILQAIDFPFL+ + +SFKDNSNLYMVLEF++GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID+ GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+KFPSHFS ELKDLL+N+LQ DLT+R+GN++NG +DIKNH WF S DW + ++K++ APF+PKCRGPGD SNFD+YEEE L+IS T KC  EF EF
Sbjct:   16 KDNKNSASLKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF 359          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Celegans
Match: kin-1 (cAMP-dependent protein kinase catalytic subunit [Source:UniProtKB/Swiss-Prot;Acc:P21137])

HSP 1 Score: 522.702 bits (1345), Expect = 0.000e+0
Identity = 247/336 (73.51%), Postives = 300/336 (89.29%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            VK FL++A+++F  ++++P Q T  LD+F+ +KTLGTGSFGRV+L  HK+S  Y+A+K+LDK K+VKLKQVEHTLNEKRILQAIDFPFL+ + +SFKDNSNLYMVLEF++GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID+ GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+KFPSHFS ELKDLL+N+LQ DLT+R+GN++NG +DIKNH WF S DW + ++K++ APF+PKCRGPGD SNFD+YEEE L+IS T KC  EF EF
Sbjct:   35 VKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF 370          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Celegans
Match: kin-1 (cAMP-dependent protein kinase catalytic subunit [Source:UniProtKB/Swiss-Prot;Acc:P21137])

HSP 1 Score: 521.931 bits (1343), Expect = 0.000e+0
Identity = 246/336 (73.21%), Postives = 300/336 (89.29%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +K FL++A+++F  ++++P Q T  LD+F+ +KTLGTGSFGRV+L  HK+S  Y+A+K+LDK K+VKLKQVEHTLNEKRILQAIDFPFL+ + +SFKDNSNLYMVLEF++GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID+ GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+KFPSHFS ELKDLL+N+LQ DLT+R+GN++NG +DIKNH WF S DW + ++K++ APF+PKCRGPGD SNFD+YEEE L+IS T KC  EF EF
Sbjct:   46 IKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF 381          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Celegans
Match: kin-1 (cAMP-dependent protein kinase catalytic subunit [Source:UniProtKB/Swiss-Prot;Acc:P21137])

HSP 1 Score: 521.931 bits (1343), Expect = 0.000e+0
Identity = 247/336 (73.51%), Postives = 300/336 (89.29%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            VK FL++A+++F  ++++P Q T  LD+F+ +KTLGTGSFGRV+L  HK+S  Y+A+K+LDK K+VKLKQVEHTLNEKRILQAIDFPFL+ + +SFKDNSNLYMVLEF++GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID+ GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+KFPSHFS ELKDLL+N+LQ DLT+R+GN++NG +DIKNH WF S DW + ++K++ APF+PKCRGPGD SNFD+YEEE L+IS T KC  EF EF
Sbjct:    8 VKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF 343          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Celegans
Match: kin-1 (cAMP-dependent protein kinase catalytic subunit [Source:UniProtKB/Swiss-Prot;Acc:P21137])

HSP 1 Score: 521.161 bits (1341), Expect = 0.000e+0
Identity = 246/337 (73.00%), Postives = 300/337 (89.02%), Query Frame = 2
Query:  161 YVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            + K FL++A+++F  ++++P Q T  LD+F+ +KTLGTGSFGRV+L  HK+S  Y+A+K+LDK K+VKLKQVEHTLNEKRILQAIDFPFL+ + +SFKDNSNLYMVLEF++GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID+ GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+KFPSHFS ELKDLL+N+LQ DLT+R+GN++NG +DIKNH WF S DW + ++K++ APF+PKCRGPGD SNFD+YEEE L+IS T KC  EF EF
Sbjct:   13 FFKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF 349          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Fly
Match: Pka-C1 (gene:FBgn0000273 transcript:FBtr0335495)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 249/353 (70.54%), Postives = 301/353 (85.27%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNS-YVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T    + D +  VK FLE+AK+ F DK+      T  LD+FE +KTLGTGSFGRV++  HK +K Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL+ L Y FKDNSNLYMVLE+V GGEMFSHLR+VG+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GYLK+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHF  +LKDLLRN+LQ DLT+R+GN++ G +DIKN  WF S DW + F+K++ APFIP+C+GPGDTSNFD+YEEE L+IS+T KC  EF EF
Sbjct:    1 MGNNATTSNKKVDAAETVKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF 353          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Fly
Match: Pka-C1 (gene:FBgn0000273 transcript:FBtr0079852)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 249/353 (70.54%), Postives = 301/353 (85.27%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNS-YVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T    + D +  VK FLE+AK+ F DK+      T  LD+FE +KTLGTGSFGRV++  HK +K Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL+ L Y FKDNSNLYMVLE+V GGEMFSHLR+VG+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GYLK+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHF  +LKDLLRN+LQ DLT+R+GN++ G +DIKN  WF S DW + F+K++ APFIP+C+GPGDTSNFD+YEEE L+IS+T KC  EF EF
Sbjct:    1 MGNNATTSNKKVDAAETVKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF 353          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Fly
Match: Pka-C1 (gene:FBgn0000273 transcript:FBtr0079851)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 249/353 (70.54%), Postives = 301/353 (85.27%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNS-YVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T    + D +  VK FLE+AK+ F DK+      T  LD+FE +KTLGTGSFGRV++  HK +K Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL+ L Y FKDNSNLYMVLE+V GGEMFSHLR+VG+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GYLK+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHF  +LKDLLRN+LQ DLT+R+GN++ G +DIKN  WF S DW + F+K++ APFIP+C+GPGDTSNFD+YEEE L+IS+T KC  EF EF
Sbjct:    1 MGNNATTSNKKVDAAETVKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF 353          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Fly
Match: Pka-C3 (gene:FBgn0000489 transcript:FBtr0075529)

HSP 1 Score: 356.295 bits (913), Expect = 1.402e-118
Identity = 162/296 (54.73%), Postives = 224/296 (75.68%), Query Frame = 2
Query:  233 YKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEE 1120
            Y LD+++I+KT+GTG+FGRV L   + S+KY A+K+L   ++++LKQ+EH  NE+ IL+ I  PF+I L++S KD+SNLYM+ ++V GGE+F++LR  GKF+   + FYA+++V A EYLH L ++YRDLKPEN+LI+  G+LKITDFGFAK+++ RTWTLCGTPEY+APEII SKG+N AVDWWALG+LI+EM  GYPPF+ +QP  IYEKI++ KI++  H  P  KDL++ +L  D T+R GNM+NGA D+K H WF   +W   + K+L  P +P     GDT NFD+Y E+
Sbjct:  186 YHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEK 481          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Fly
Match: Pka-C3 (gene:FBgn0000489 transcript:FBtr0075528)

HSP 1 Score: 355.91 bits (912), Expect = 2.066e-117
Identity = 162/296 (54.73%), Postives = 224/296 (75.68%), Query Frame = 2
Query:  233 YKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEE 1120
            Y LD+++I+KT+GTG+FGRV L   + S+KY A+K+L   ++++LKQ+EH  NE+ IL+ I  PF+I L++S KD+SNLYM+ ++V GGE+F++LR  GKF+   + FYA+++V A EYLH L ++YRDLKPEN+LI+  G+LKITDFGFAK+++ RTWTLCGTPEY+APEII SKG+N AVDWWALG+LI+EM  GYPPF+ +QP  IYEKI++ KI++  H  P  KDL++ +L  D T+R GNM+NGA D+K H WF   +W   + K+L  P +P     GDT NFD+Y E+
Sbjct:  269 YHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEK 564          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Zebrafish
Match: prkacbb (protein kinase, cAMP-dependent, catalytic, beta b [Source:ZFIN;Acc:ZDB-GENE-050904-4])

HSP 1 Score: 523.857 bits (1348), Expect = 0.000e+0
Identity = 250/352 (71.02%), Postives = 305/352 (86.65%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+  +  S VK FL +AK++F  K++ P+Q T  LD+F+  KTLGTGSFGRV+L  HK S +Y+A+KVLDK K+VKLKQVEHTLNEKRILQA+ FPFL++L+Y+FKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN+RNG +DIKNH WF + DW + +++++ APFIPKCRGPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNAATAKKGNELES-VKEFLAKAKEDFLRKWESPQQSTTCLDDFDRQKTLGTGSFGRVLLVKHKASDQYYAMKVLDKQKVVKLKQVEHTLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLRNGVNDIKNHKWFATTDWIAIYERKVEAPFIPKCRGPGDTSNFDDYEEEDIRVSVTEKCAKEFSEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Zebrafish
Match: prkacaa (protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [Source:ZFIN;Acc:ZDB-GENE-050114-6])

HSP 1 Score: 521.546 bits (1342), Expect = 0.000e+0
Identity = 245/352 (69.60%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN PT K    +   VK FL +AK++F  K+++P Q T  LD FE LKTLGTGSFGRV+L  HK+S ++ A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L++SFKDN+NLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW + ++K++ APFIPKC+GPGDTSNFD+Y+EE +++S T KC  EF EF
Sbjct:    1 MGNAPTAKNKGNEMESVKEFLAKAKEDFLKKWENPAQNTASLDHFERLKTLGTGSFGRVMLVKHKESGQHFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEHSFKDNTNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKGHKWFATTDWIAIYQKKVEAPFIPKCKGPGDTSNFDDYDEEEIRVSITEKCGKEFAEF 352          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Zebrafish
Match: prkacab (protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-040801-208])

HSP 1 Score: 518.85 bits (1335), Expect = 0.000e+0
Identity = 241/352 (68.47%), Postives = 306/352 (86.93%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGNTP  KR  +  S VK FL  AK++F  K+++P Q T  L++F+ LKTLGTGSFGRV+L  H+++ +++A+K+L+K K+VKLKQ+EHTLNEKRILQA+ FPFL++L+YSFKDN+NLYMV+++V GGEMFSHLRR+G+FSE HA+FYASQ+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIK H WF + DW + +++ + APF+PKCRGPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNTPAAKRGNEMES-VKEFLAFAKEDFLRKWENPAQNTACLEDFDRLKTLGTGSFGRVMLVRHRETGQHYAMKILNKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEYSFKDNTNLYMVMQYVQGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLMYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKGHKWFSTTDWIAIYQRRVEAPFVPKCRGPGDTSNFDDYEEEEIRVSFTEKCAKEFAEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Zebrafish
Match: prkacba (protein kinase, cAMP-dependent, catalytic, beta a [Source:ZFIN;Acc:ZDB-GENE-040426-1351])

HSP 1 Score: 499.975 bits (1286), Expect = 1.747e-176
Identity = 233/339 (68.73%), Postives = 301/339 (88.79%), Query Frame = 2
Query:  155 NSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            ++ +K  L +AK++F +K++  ++ T  LD+F+ LKTLGTGSFGRV+L  HK+S++Y A+K+LDKLK+VKLKQ+EHTLNEK+ILQA+ FPFL+KL+ +FKDNSNLYMV+ ++ GGEMFSHLRR+G+FSE +A+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+++PSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIKNH WF S DW + ++K++ AP IPKCRGPGDTSNFD Y+EEV+++S + +C+ EF++F
Sbjct:   57 DTAMKETLAKAKEDFLNKWECQQKSTACLDDFDKLKTLGTGSFGRVMLVKHKQSEQYFAMKILDKLKVVKLKQIEHTLNEKKILQAVSFPFLVKLECAFKDNSNLYMVMRYIQGGEMFSHLRRIGRFSEQNARFYAAQIVLTFEYLHMLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRYPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKNHRWFASTDWIAIYEKKVDAPIIPKCRGPGDTSNFDEYDEEVIRVSVSEQCSKEFLDF 395          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Zebrafish
Match: prkacba (protein kinase, cAMP-dependent, catalytic, beta a [Source:ZFIN;Acc:ZDB-GENE-040426-1351])

HSP 1 Score: 499.975 bits (1286), Expect = 1.747e-176
Identity = 233/339 (68.73%), Postives = 301/339 (88.79%), Query Frame = 2
Query:  155 NSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            ++ +K  L +AK++F +K++  ++ T  LD+F+ LKTLGTGSFGRV+L  HK+S++Y A+K+LDKLK+VKLKQ+EHTLNEK+ILQA+ FPFL+KL+ +FKDNSNLYMV+ ++ GGEMFSHLRR+G+FSE +A+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K+++PSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIKNH WF S DW + ++K++ AP IPKCRGPGDTSNFD Y+EEV+++S + +C+ EF++F
Sbjct:   57 DTAMKETLAKAKEDFLNKWECQQKSTACLDDFDKLKTLGTGSFGRVMLVKHKQSEQYFAMKILDKLKVVKLKQIEHTLNEKKILQAVSFPFLVKLECAFKDNSNLYMVMRYIQGGEMFSHLRRIGRFSEQNARFYAAQIVLTFEYLHMLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRYPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKNHRWFASTDWIAIYEKKVDAPIIPKCRGPGDTSNFDEYDEEVIRVSVSEQCSKEFLDF 395          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Xenopus
Match: prkacb (protein kinase cAMP-activated catalytic subunit beta [Source:NCBI gene;Acc:100038053])

HSP 1 Score: 523.472 bits (1347), Expect = 0.000e+0
Identity = 246/352 (69.89%), Postives = 308/352 (87.50%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+  +  S VK FL +AK++F  K++ P Q T  LD+FE +KTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIKNH WF + DW + +++++ APFIPKCRGPGDTSNFD+YEEE +++S T KC  EF +F
Sbjct:    1 MGNAATAKKGNEIES-VKEFLAKAKEDFLRKWETPPQNTASLDDFERIKTLGTGSFGRVMLVKHKGAEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRGPGDTSNFDDYEEEDIRVSLTEKCAKEFADF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Xenopus
Match: ints8 (integrator complex subunit 8 [Source:Xenbase;Acc:XB-GENE-980129])

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 245/352 (69.60%), Postives = 306/352 (86.93%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+  +  S VK FL +AK++F  K+++P Q T  L++FE +KTLGTGSFGRV+L  HK++  + A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYASQ+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW + ++K++ APFIPKC+GPGDTSNFD+YEEE +++S T KC  EF +F
Sbjct:    1 MGNAATAKKGGEIES-VKEFLAKAKEDFLKKWENPAQNTAHLEQFERIKTLGTGSFGRVMLVRHKENGSHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKGPGDTSNFDDYEEEEIRVSITEKCAKEFSDF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Xenopus
Match: ints8 (integrator complex subunit 8 [Source:Xenbase;Acc:XB-GENE-980129])

HSP 1 Score: 516.924 bits (1330), Expect = 0.000e+0
Identity = 244/358 (68.16%), Postives = 307/358 (85.75%), Query Frame = 2
Query:   98 ISVYPLMGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            ++   L  + P + R E    YVK FL +AK++F  K+++P Q T  L++FE +KTLGTGSFGRV+L  HK++  + A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYASQ+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW + ++K++ APFIPKC+GPGDTSNFD+YEEE +++S T KC  EF +F
Sbjct:   12 LATSQLSPSPPNLDR-EGQERYVKEFLAKAKEDFLKKWENPAQNTAHLEQFERIKTLGTGSFGRVMLVRHKENGSHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKGPGDTSNFDDYEEEEIRVSITEKCAKEFSDF 368          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Xenopus
Match: ints8 (integrator complex subunit 8 [Source:Xenbase;Acc:XB-GENE-980129])

HSP 1 Score: 512.686 bits (1319), Expect = 0.000e+0
Identity = 239/337 (70.92%), Postives = 299/337 (88.72%), Query Frame = 2
Query:  161 YVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +VK FL +AK++F  K+++P Q T  L++FE +KTLGTGSFGRV+L  HK++  + A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYASQ+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW + ++K++ APFIPKC+GPGDTSNFD+YEEE +++S T KC  EF +F
Sbjct:    1 FVKEFLAKAKEDFLKKWENPAQNTAHLEQFERIKTLGTGSFGRVMLVRHKENGSHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKGPGDTSNFDDYEEEEIRVSITEKCAKEFSDF 337          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Xenopus
Match: ints8 (integrator complex subunit 8 [Source:Xenbase;Acc:XB-GENE-980129])

HSP 1 Score: 512.301 bits (1318), Expect = 0.000e+0
Identity = 240/338 (71.01%), Postives = 299/338 (88.46%), Query Frame = 2
Query:  158 SYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            S VK FL +AK++F  K+++P Q T  L++FE +KTLGTGSFGRV+L  HK++  + A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYASQ+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW + ++K++ APFIPKC+GPGDTSNFD+YEEE +++S T KC  EF +F
Sbjct:   31 STVKEFLAKAKEDFLKKWENPAQNTAHLEQFERIKTLGTGSFGRVMLVRHKENGSHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKGPGDTSNFDDYEEEEIRVSITEKCAKEFSDF 368          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Mouse
Match: Prkaca (protein kinase, cAMP dependent, catalytic, alpha [Source:MGI Symbol;Acc:MGI:97592])

HSP 1 Score: 516.153 bits (1328), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 305/352 (86.65%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T +LD+F+ +KTLGTGSFGRV+L  HK+S  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Mouse
Match: Prkaca (protein kinase, cAMP dependent, catalytic, alpha [Source:MGI Symbol;Acc:MGI:97592])

HSP 1 Score: 509.605 bits (1311), Expect = 0.000e+0
Identity = 238/336 (70.83%), Postives = 298/336 (88.69%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            VK FL +AK++F  K++ P Q T +LD+F+ +KTLGTGSFGRV+L  HK+S  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    8 VKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 343          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Mouse
Match: Prkacb (protein kinase, cAMP dependent, catalytic, beta [Source:MGI Symbol;Acc:MGI:97594])

HSP 1 Score: 508.834 bits (1309), Expect = 1.526e-180
Identity = 243/352 (69.03%), Postives = 303/352 (86.08%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGNT   K+  +  S VK FL +AK++F  K+++P      L++FE  KTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIK H WF + DW + +++++ APFIPK RG GDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNTAIAKKGSEVES-VKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Mouse
Match: Prkacb (protein kinase, cAMP dependent, catalytic, beta [Source:MGI Symbol;Acc:MGI:97594])

HSP 1 Score: 501.516 bits (1290), Expect = 8.482e-178
Identity = 237/336 (70.54%), Postives = 295/336 (87.80%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            VK FL +AK++F  K+++P      L++FE  KTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIK H WF + DW + +++++ APFIPK RG GDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    3 VKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF 338          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Mouse
Match: Prkacb (protein kinase, cAMP dependent, catalytic, beta [Source:MGI Symbol;Acc:MGI:97594])

HSP 1 Score: 499.975 bits (1286), Expect = 3.126e-177
Identity = 236/336 (70.24%), Postives = 295/336 (87.80%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +K FL +AK++F  K+++P      L++FE  KTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIK H WF + DW + +++++ APFIPK RG GDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    4 LKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF 339          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. UniProt/SwissProt
Match: sp|P12370|KAPC1_DROME (cAMP-dependent protein kinase catalytic subunit 1 OS=Drosophila melanogaster OX=7227 GN=Pka-C1 PE=1 SV=3)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 249/353 (70.54%), Postives = 301/353 (85.27%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNS-YVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T    + D +  VK FLE+AK+ F DK+      T  LD+FE +KTLGTGSFGRV++  HK +K Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL+ L Y FKDNSNLYMVLE+V GGEMFSHLR+VG+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GYLK+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHF  +LKDLLRN+LQ DLT+R+GN++ G +DIKN  WF S DW + F+K++ APFIP+C+GPGDTSNFD+YEEE L+IS+T KC  EF EF
Sbjct:    1 MGNNATTSNKKVDAAETVKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF 353          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. UniProt/SwissProt
Match: sp|P05132|KAPCA_MOUSE (cAMP-dependent protein kinase catalytic subunit alpha OS=Mus musculus OX=10090 GN=Prkaca PE=1 SV=3)

HSP 1 Score: 516.153 bits (1328), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 305/352 (86.65%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T +LD+F+ +KTLGTGSFGRV+L  HK+S  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. UniProt/SwissProt
Match: sp|P36887|KAPCA_PIG (cAMP-dependent protein kinase catalytic subunit alpha OS=Sus scrofa OX=9823 GN=PRKACA PE=1 SV=4)

HSP 1 Score: 514.612 bits (1324), Expect = 0.000e+0
Identity = 244/352 (69.32%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K+++P Q T  LD+FE +KTLGTGSFGRV+L  HK++  + A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. UniProt/SwissProt
Match: sp|P27791|KAPCA_RAT (cAMP-dependent protein kinase catalytic subunit alpha OS=Rattus norvegicus OX=10116 GN=Prkaca PE=1 SV=2)

HSP 1 Score: 514.227 bits (1323), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T +LD F+ +KTLGTGSFGRV+L  HK+S  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWEDPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. UniProt/SwissProt
Match: sp|P17612|KAPCA_HUMAN (cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2)

HSP 1 Score: 514.227 bits (1323), Expect = 0.000e+0
Identity = 243/352 (69.03%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T  LD+FE +KTLGTGSFGRV+L  HK++  ++A+K+LDK K+VKLKQ+EHTLNEKRILQA++FPFL+KL++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPK +GPGDTSNFD+YEEE +++S   KC  EF EF
Sbjct:    1 MGNAAAAKKGSEQES-VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. TrEMBL
Match: A0A0X3NYD4 (cAMP-dependent protein kinase catalytic subunit alpha OS=Schistocephalus solidus OX=70667 GN=KAPCA PE=3 SV=1)

HSP 1 Score: 541.576 bits (1394), Expect = 0.000e+0
Identity = 261/352 (74.15%), Postives = 309/352 (87.78%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    KR E  +  VK FL++AKK+F +K++ P Q T  LD+F+ LKTLGTGSFGRV+L  HK  K Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL+KL+Y FKDNSNLYMVLEFVNGGEMFSHLR++G+FSE+HA+FYASQVVLAFEYLHHL+L+YRDLKPENILID +GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPF+ADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG SDIKNH WF   DW+S +K+EL APF+PKC+GPGD SNFD+YEEE L+I+TT KC  +F EF
Sbjct:    1 MGNAAASKRGEPAD--VKAFLDDAKKDFLEKWEKPSQNTACLDDFDRLKTLGTGSFGRVMLVQHKAKKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAISFPFLVKLEYHFKDNSNLYMVLEFVNGGEMFSHLRKIGRFSEHHARFYASQVVLAFEYLHHLELVYRDLKPENILIDQQGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFYADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVSDIKNHKWFAPTDWFSIYKRELEAPFMPKCKGPGDASNFDDYEEEPLRIATTEKCVKDFAEF 350          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. TrEMBL
Match: D2JWR5 (cAMP-dependent protein kinase catalytic subunit OS=Schistosoma japonicum OX=6182 GN=EWB00_007721 PE=2 SV=1)

HSP 1 Score: 537.724 bits (1384), Expect = 0.000e+0
Identity = 259/352 (73.58%), Postives = 305/352 (86.65%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+   D + VK  LEEAKK F +K++ P Q T  LD F+ +KTLGTGSFGRV+L  HK SK+Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL++LDY FKDNSNLYMVLEFVNGGEMFSHLRR+G+FSE+H++FYASQVVLAFEYLHHL+L+YRDLKPENILID  GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYE+IV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW+S FK+++ APF PKC G GD SNFD+YEEE L+I+TT KC  EF EF
Sbjct:    1 MGNAQTAKKG--DPADVKALLEEAKKEFLEKWEKPAQNTATLDSFDRIKTLGTGSFGRVMLVQHKVSKEYYAMKILDKQKVVKLKQVEHTLNEKRILQAISFPFLVRLDYHFKDNSNLYMVLEFVNGGEMFSHLRRIGRFSESHSRFYASQVVLAFEYLHHLELVYRDLKPENILIDQYGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYERIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKTHKWFATTDWFSIFKRDIEAPFTPKCSGAGDASNFDDYEEEPLRIATTEKCAKEFSEF 350          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. TrEMBL
Match: A0A1S3JGB8 (cAMP-dependent protein kinase catalytic subunit isoform X12 OS=Lingula unguis OX=7574 GN=LOC106173017 PE=3 SV=1)

HSP 1 Score: 536.184 bits (1380), Expect = 0.000e+0
Identity = 255/353 (72.24%), Postives = 309/353 (87.54%), Query Frame = 2
Query:  116 MGNTPTVKR-DEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+ D  +N  VK FL +AK  FSDK++ P Q T  LD+FE +KTLGTGSFGRV+L  HK+SK+Y+A+K+LDK K+VKLKQVEHTLNEKRILQA+ FPFL+ L+Y FKDNSNLYMVLEFV GGEMFSHLRR+G+FSE+H++FYASQ+VLAFEYLH LDL+YRDLKPENILID+ G+LK+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIKNH WF + DW + ++K++ APFIPKC+GPGD SNFD+YEEE L+IS+T KC  EF +F
Sbjct:    1 MGNAQTAKKLDPAEN--VKAFLAQAKAEFSDKWEKPSQNTAGLDDFERIKTLGTGSFGRVMLVQHKQSKQYYAMKILDKQKVVKLKQVEHTLNEKRILQAVSFPFLVSLEYHFKDNSNLYMVLEFVTGGEMFSHLRRIGRFSESHSRFYASQIVLAFEYLHALDLVYRDLKPENILIDSSGWLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQKKVEAPFIPKCKGPGDASNFDDYEEEPLRISSTEKCAKEFADF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. TrEMBL
Match: D2JVC2 (cAMP-dependent protein kinase catalytic subunit OS=Schistosoma haematobium OX=6185 PE=2 SV=1)

HSP 1 Score: 535.798 bits (1379), Expect = 0.000e+0
Identity = 257/352 (73.01%), Postives = 303/352 (86.08%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+   D + VK  LEEAKK F +K++ P Q T  LD F+ +KTLGTGSFGRV+L  HK SK+Y+A+K LDK K+VKLKQVEHTLNEKRILQAI FPFL++LDY FKDNSNLYMVLEFVNGGEMFSHLRR+G+FSE+H++FYASQVVLAFEYLHHL+L+YRDLKPEN+LID  GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYE+IV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW+S FK+++ APF PKC G GD SNFD+YEEE L+I+TT KC  EF EF
Sbjct:    1 MGNAQAAKKG--DPADVKALLEEAKKEFLEKWEKPAQNTATLDSFDRIKTLGTGSFGRVMLVQHKVSKEYYAMKTLDKQKVVKLKQVEHTLNEKRILQAISFPFLVRLDYHFKDNSNLYMVLEFVNGGEMFSHLRRIGRFSESHSRFYASQVVLAFEYLHHLELVYRDLKPENVLIDQYGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYERIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKTHKWFATTDWFSIFKRDIEAPFTPKCSGAGDASNFDDYEEEPLRIATTEKCAKEFSEF 350          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. TrEMBL
Match: C7DPD5 (Serine/threonine kinase; cAMP-dependent protein kinase catalytic subunit OS=Schistosoma mansoni OX=6183 PE=2 SV=1)

HSP 1 Score: 535.798 bits (1379), Expect = 0.000e+0
Identity = 258/352 (73.30%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+   D + VK  LEEAKK F +K++ P Q T  LD F+ +KTLGTGSFGRV+L  HK SK+Y+A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL++LDY FKDNSNLYMVLEFVNGGEMFSHLRR+G+FSE+H++FYASQVVLAFEYLHHL+L+YRDLKPENILID  GYLKITDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYE+IV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIK H WF + DW+S FK+++ APF PKC G GD SNFD+YEEE L+I+TT KC  EF EF
Sbjct:    1 MGNAQAAKKG--DPADVKALLEEAKKEFLEKWEKPAQNTATLDSFDRIKTLGTGSFGRVMLVQHKVSKEYYAMKILDKQKVVKLKQVEHTLNEKRILQAISFPFLVRLDYHFKDNSNLYMVLEFVNGGEMFSHLRRIGRFSESHSRFYASQVVLAFEYLHHLELVYRDLKPENILIDQYGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYERIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKTHKWFATTDWFSIFKRDIEAPFTPKCSGAGDASNFDDYEEEPLRIATTEKCAKEFSEF 350          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Cavefish
Match: prkacaa (cAMP-dependent protein kinase catalytic subunit alpha [Source:NCBI gene;Acc:103024963])

HSP 1 Score: 524.628 bits (1350), Expect = 0.000e+0
Identity = 246/352 (69.89%), Postives = 305/352 (86.65%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN PT K    +   VK FL +AK++F  K+++P Q T  LD+FE LKTLGTGSFGRV+L  HK++ ++ A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L++SFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG SDIK H WF + DW + +++++ APFIPKC+GPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNAPTAKNKGNEMESVKEFLAKAKEDFLKKWENPAQNTASLDQFERLKTLGTGSFGRVMLVKHKETGQHFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEHSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKGHKWFATTDWIAIYQRKVEAPFIPKCKGPGDTSNFDDYEEEEIRVSFTEKCGKEFAEF 352          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Cavefish
Match: prkacab (cAMP-dependent protein kinase catalytic subunit alpha [Source:NCBI gene;Acc:103023241])

HSP 1 Score: 521.546 bits (1342), Expect = 0.000e+0
Identity = 242/352 (68.75%), Postives = 305/352 (86.65%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGNTP  KR  +  S V+ FL  A+++F  K++ P Q T  LD+F++LKTLGTGSFGRV+L  H+++ +++A+K+L+K K+VKLKQ+EHTLNEKRILQA+ FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYASQ+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI IYEKIV+ K++FPSHFS +LK+LLRN+LQ DLT+R+GN++NG +DIK H WF + DW + +++ + APFIPKCRGPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNTPAAKRGNEMES-VREFLALAREDFLRKWETPAQNTASLDQFDLLKTLGTGSFGRVMLVRHRENGQHYAMKILNKQKVVKLKQIEHTLNEKRILQAVSFPFLVQLEYSFKDNSNLYMVMEYVQGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIHIYEKIVSGKVRFPSHFSSDLKELLRNLLQVDLTKRYGNLKNGVNDIKGHKWFSTTDWIAIYQRRVEAPFIPKCRGPGDTSNFDDYEEEEIRVSLTEKCGKEFAEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Cavefish
Match: ENSAMXT00000050353.1 (protein kinase cAMP-activated catalytic subunit beta [Source:NCBI gene;Acc:103029308])

HSP 1 Score: 520.005 bits (1338), Expect = 0.000e+0
Identity = 247/352 (70.17%), Postives = 306/352 (86.93%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T  LD+FE LKTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L+Y+FKDNSNLYMV+E+V GGEMFSHLRR+G+FSE+HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ AP IPKCRGPGDTSNFD+YEEE ++IS T KC  EF+EF
Sbjct:    1 MGNAAAAKKGNELES-VKEFLAKAKEDFLRKWECPPQSTTCLDDFERLKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEHHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYERKVEAPIIPKCRGPGDTSNFDDYEEEEIRISDTEKCAKEFLEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Cavefish
Match: prkacbb (cAMP-dependent protein kinase catalytic subunit beta [Source:NCBI gene;Acc:103034112])

HSP 1 Score: 518.85 bits (1335), Expect = 0.000e+0
Identity = 247/352 (70.17%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN    K+  +  S VK FL +AK++F  K++ P Q T  LD+FE LKTLGTGSFGRV+L  HK ++++ A+KVLDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L+YSFKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIKNH WF + DW + +++++ APFIPKCRGPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNAAAAKKGNELES-VKEFLAKAKEDFLRKWECPPQSTTTLDDFERLKTLGTGSFGRVMLVKHKGTEQFFAMKVLDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYERKVEAPFIPKCRGPGDTSNFDDYEEEDIRVSVTEKCAKEFTEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Cavefish
Match: ENSAMXT00000056663.1 (protein kinase cAMP-activated catalytic subunit beta [Source:NCBI gene;Acc:103029308])

HSP 1 Score: 514.227 bits (1323), Expect = 0.000e+0
Identity = 241/336 (71.73%), Postives = 299/336 (88.99%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +K FL +AK++F  K++ P Q T  LD+FE LKTLGTGSFGRV+L  HK +++Y+A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L+Y+FKDNSNLYMV+E+V GGEMFSHLRR+G+FSE+HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ AP IPKCRGPGDTSNFD+YEEE ++IS T KC  EF+EF
Sbjct:   60 MKEFLAKAKEDFLRKWECPPQSTTCLDDFERLKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEHHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYERKVEAPIIPKCRGPGDTSNFDDYEEEEIRISDTEKCAKEFLEF 395          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001814.1 (pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gene:ENSPMAG00000001637.1 transcript:ENSPMAT00000001814.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 462.225 bits (1188), Expect = 5.545e-164
Identity = 203/267 (76.03%), Postives = 245/267 (91.76%), Query Frame = 2
Query:  371 QVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            QVEHTLNEKRILQAI FPFL++L+YSFKDNSNLYMVLE+V GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APFIPKC+GPGD SNFD+YEEE ++IS+T KC  EF +F
Sbjct:   22 QVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNFDDYEEEEIRISSTEKCAKEFADF 288          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002200.1 (pep scaffold:Pmarinus_7.0:GL479132:31244:36905:-1 gene:ENSPMAG00000001993.1 transcript:ENSPMAT00000002200.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 250.366 bits (638), Expect = 4.899e-80
Identity = 121/296 (40.88%), Postives = 185/296 (62.50%), Query Frame = 2
Query:  248 FEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIK-GR-TWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIV--AAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEV 1123
             +++ TLG G FGRV L   K S    A+K L K  +V+ +Q EH  +EKRILQ    PF+++   +F+D   +++++E   GGE++S LR  G F E  A+F  + VV A  YLH   ++YRDLKPEN+L+D +GY+K+ DFGFAK++  GR  WT CGTPEY+ PE+I+++G++   D WALG+L++E+ AG PPF    P+K Y  I+    ++ FP+      +D++R + + + + R GN ++G  D++ H WF  FDW S    +L +P   +  GP D  NFD + E++
Sbjct:   34 MDVIATLGVGGFGRVQLVKLKDSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVRFYRTFRDQKFVFLLMEACLGGELWSVLRDSGGFQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPNEVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDL 329          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004852.1 (pep scaffold:Pmarinus_7.0:GL488704:3417:7135:1 gene:ENSPMAG00000004407.1 transcript:ENSPMAT00000004852.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 230.335 bits (586), Expect = 1.504e-74
Identity = 118/168 (70.24%), Postives = 148/168 (88.10%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKI 667
            VK FL +AK++F  K+++P+Q T  LD+FE +KTLGTGSFGRV+L  HK + +Y A+K+LDK K+VKLKQVEHTLNEKRILQAI FPFL+ L+YS+KDNSNLYMVLE+V GGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH LDLIYRDLKPEN+LID +GY+++
Sbjct:   16 VKEFLAKAKEDFLKKWENPQQNTSCLDDFERMKTLGTGSFGRVMLVKHKATDRYFAMKILDKQKVVKLKQVEHTLNEKRILQAISFPFLVSLEYSYKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 235.728 bits (600), Expect = 8.951e-73
Identity = 127/312 (40.71%), Postives = 183/312 (58.65%), Query Frame = 2
Query:  239 LDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLH-HLDLIYRDLKPENILIDTKGYLKITDFGFAKR--IKGRTW-TLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEF 1162
            ++ F+ LK LG G+FG+VIL   K + +Y+A+K+L K  IV   +V HTL E R+LQ    PFL  L YSF+ +  L  V+E+VNGGE+F HL R   FSE+  +FY +++V A +YLH   +++YRDLK EN+++D  G++KI DFG  K     G T  T CGTPEYLAPE++    Y  AVDWW LG++++EM  G  PF+     K++E I+   I+FP   S + + LL  +L+ D  +R G   + A +I  H +F    W   + +++  PF P+     DT  FD   EE    + T    D F
Sbjct:  147 MNNFDYLKLLGKGTFGKVILVREKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFD---EEFTAQTITITPPDRF 455          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 232.646 bits (592), Expect = 3.437e-72
Identity = 127/324 (39.20%), Postives = 192/324 (59.26%), Query Frame = 2
Query:  236 KLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRIL-QAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKR---IKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFD-NYEEEVLKI--------STTCKCTDEFVE 1168
            K  +F+ L  LG GSFG+V+LA HK    ++AVKV+ K  I++ K+ +H + E+ +L + +  PFL+ L YSF+    LY V+++VNGGE+F HL+R G F E+ A+FYA+++  A  YLH L+++YRDLKPENIL+D +G++ +TDFG  K        T T CGTPEYLAPE++    Y+  VDWW LG +++EM  G PPF++    ++YE I+   ++     +     +L  +L  D  +R G   +   +IKNHV+F + +W     K + +P+ P   GP D  NFD  +  E L +        S+ C   DE  +
Sbjct:   88 KPSDFDFLTVLGKGSFGKVLLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILHQPLQLRPCTTNAAISVLEGLLHKDPHQRLGATSD-ILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFDPAFTAEPLSMSMAQSSDTSSVCANVDEAAD 410          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 325.094 bits (832), Expect = 6.591e-109
Identity = 156/299 (52.17%), Postives = 221/299 (73.91%), Query Frame = 2
Query:  233 YKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPK-CRGPGDTSNFDNYEEEVL 1126
            Y L +F+I++TLGTGSFGRV L     + +Y+A+KVL K ++VK+KQVEHT +E+R+L+ ++ PFLI++  +F+D  N++MV++++ GGE+FS LR+  +F    AKFYA++V+LA EYLH  ++IYRDLKPENIL+D  G++KITDFGFAK ++  TWTLCGTP+Y+APE+I +K YN +VDWW+LG+LI+EM AGY PF+   P+K YEKI+  K+ +P +F P++ DLL  ++  DLTRR GN+++G+ DIK H WF    W     K++  P+ P    G GDTS FD Y EE L
Sbjct:   65 YTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQYPEEQL 363          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 313.153 bits (801), Expect = 5.523e-104
Identity = 150/297 (50.51%), Postives = 214/297 (72.05%), Query Frame = 2
Query:  233 YKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKC-RGPGDTSNFDNYEEE 1120
            Y L +F+IL+TLGTGSFGRV L     + +++A+K L K  IVKLKQVEHT +E+R+L  +  PF+I++  +F+D+  ++MV++++ GGE+FS LR+  +F    AKFYA++V LA EYLH  D+IYRDLKPENIL+D  G++KITDFGFAK +   T+TLCGTP+Y+APE++ +K YN +VDWW+ G+LI+EM AGY PF+    +K YE I+ A++KFP  F P+ +DLL+ ++  DL+ R GN++NG+ D+KNH WF+   W     + +  P+ P   +G GDTS FD Y EE
Sbjct:   83 YSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEE 379          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 311.997 bits (798), Expect = 1.562e-103
Identity = 148/297 (49.83%), Postives = 214/297 (72.05%), Query Frame = 2
Query:  233 YKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKC-RGPGDTSNFDNYEEE 1120
            Y L +F+IL+TLGTGSFGRV L   + + +Y+A+KVL K  +V+LKQVEHT +E+ +L  +  PF+I++  +F+D   ++M+++++ GGE+FS LR+  +F    AKFYA++V LA EYLH  D+IYRDLKPENIL+D  G++KITDFGFAK +   T+TLCGTP+Y+APE++ +K YN ++DWW+ GILI+EM AGY PF+    +K YEKI+ A+++FP  F+ ++KDLL  ++  DL++R GN++NG  D+KNH WF    W     + +  P+ P   +G GDTS FD Y EE
Sbjct:   82 YSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEE 378          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609])

HSP 1 Score: 271.166 bits (692), Expect = 1.538e-84
Identity = 137/330 (41.52%), Postives = 202/330 (61.21%), Query Frame = 2
Query:  185 AKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAK---RIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFV 1165
             K N S  Y   + +   +D+F++LK +G GSFG+V+    K ++K +A+K + K  IV   +V HTL E+ +L  +D PF++ L +SF+    LY VL F+NGGE+F HL++ G+F  + A+FY ++++ A + LH LD++YRDLKPENIL+D +G++ + DFG  K   +   +T T CGTPEYLAPE+++  GY  AVDWW LG+L++EM  G PP++ +   K+Y+KI+   + FP  F  + KDLL  +L  D TRR G   NGA +I+NH +F    W     K  I P+ P      DTSNFD   EE  +        DE++
Sbjct:  326 GKINISIDYKPSRNKPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLG--YNGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFD---EEFTREKPIDSVVDEYL 650          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710])

HSP 1 Score: 266.544 bits (680), Expect = 8.261e-83
Identity = 137/330 (41.52%), Postives = 201/330 (60.91%), Query Frame = 2
Query:  185 AKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAK---RIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFV 1165
             K N +  Y   K +   +D+F++LK +G GSFG+V+    K ++K +A+K L K  IV   +V HTL E+ +L  +D PF++ L +SF+    LY+VL F+NGGE+F HL+  G+FS   ++FY ++++ A + LH LD+IYRDLKPENIL+D +G++ + DFG  K   +   +T T CGTPEYLAPEI++ +GY   VDWW LGIL++EM  G PP++ +    +Y+KI+   + FP  F P  KDLL  +L  D +RR G   NG  +I+NH +F    W     K  I P+ P  +   DT+NFD   +E  K        DE++
Sbjct:  323 GKLNITVDYKPSKNKPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLG--VNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFD---QEFTKEKPIDSVVDEYL 647          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Nematostella
Match: EDO35228 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM62])

HSP 1 Score: 332.798 bits (852), Expect = 3.209e-112
Identity = 157/301 (52.16%), Postives = 220/301 (73.09%), Query Frame = 2
Query:  221 KQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHF-SPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEE 1120
            K +   L +FE+ KTLGTG+FGRV+LA  ++  +++A+K+++  ++++LKQVEH  NEK IL +I+ PF++ L ++  D + LYM+LE+  GGE+F++LR  G+F+     F+ S++V A +YLH   ++YRDLKPENIL+D  G++K+TDFGFAK +  +TWTLCGTPEYLAPEII SKG+N AVDWWALGILI+EM  GYPPFF D P  IYEKI++ K+++P H  +   KDL++ +L  D TRR G+M+NG+ D+KNH WF   DW    +++L  P  PK   PGDT NFD+Y EE
Sbjct:    9 KDKRTTLQDFELSKTLGTGTFGRVLLARDRRGGEFYALKIMNISEVIRLKQVEHVQNEKNILMSIEHPFIVNLLWTQHDQTFLYMLLEYACGGELFTYLRTAGRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDRDGHVKLTDFGFAKEVHDKTWTLCGTPEYLAPEIIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPFGIYEKILSGKVEWPKHMDNTSAKDLIKKLLVHDRTRRLGSMKNGSEDVKNHKWFKVIDWNLVLQRKLKPPINPKISHPGDTRNFDDYPEE 309          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521])

HSP 1 Score: 244.202 bits (622), Expect = 1.966e-76
Identity = 124/312 (39.74%), Postives = 177/312 (56.73%), Query Frame = 2
Query:  194 NFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILAL----HKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRI---KGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDN 1108
              S++  +PK E    + FE+LK LG G +G+V L      H K K +    +     I   K   HT  E+ IL+ +  PF++ L Y+F+    LY++LE+++GGE+F  L R G F E+ A FY S++ +A E+LH   ++YRDLKPENIL+D  G++K+TDFG  K        T T CGT EY+APEI+   G+  AVDWW+LG L+++M  G PPF AD   K  +KI+  K+  P + +PE KD +R +L+     R G M   A+ IK H +F    W     K++  PF P   G  D S FD+
Sbjct:   47 QLSEETVNPKDEKVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKGKLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFDS 358          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Nematostella
Match: EDO38407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCZ7])

HSP 1 Score: 250.366 bits (638), Expect = 2.539e-76
Identity = 133/335 (39.70%), Postives = 202/335 (60.30%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAK--KNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIK-GR-TWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAA--KIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNF 1102
            +GN   ++RD+ D+S   +  + A   +   D++        +L++  ++KTLG G FGRV L      K+  A+K L K  IV+ +Q +H ++EK+I+   + PF+++L  +FKD   LYM+LE   GGE+++ LR  G F ++  +FY   V+ AF+YLH   ++YRDLKPEN+L+D  GY K+ DFGFAK+I  GR TWT CGTPEY+APEII++KG++ + D+W+LGIL++E+  G PPF    P+K Y  I+     I FP   +     L++ + + +   R G  + G  DI  H WF  F+W     ++L +P  PK + P D SNF
Sbjct:  311 IGNLDDIQRDQYDDSQRGVDPQTASHLRAQQDEF-----ANVRLEDLTVVKTLGIGGFGRVELVQVAGDKRTFALKTLKKHHIVETRQQDHIMSEKKIMMESNSPFIVRLHKTFKDKKYLYMLLEVCLGGELWTILRDRGSFDDSTTRFYVGCVIEAFQYLHSKGIVYRDLKPENLLLDGHGYCKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILMYELLTGSPPFSGTDPMKTYNIILKGIDMIDFPRKITRNAHALIKKLCRDNPVERLGYQKGGLKDIMKHKWFDGFNWDGLRSRKLNSPIAPKIKSPVDASNF 640          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2])

HSP 1 Score: 241.506 bits (615), Expect = 1.322e-75
Identity = 122/294 (41.50%), Postives = 185/294 (62.93%), Query Frame = 2
Query:  236 KLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRIL-QAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKR---IKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFD 1105
            K  +F  LK +G GSFG+V L+ +K+  K++A+KVL+K  I K  + +H + E+ +L Q +  PFL+ L YSF+    LY VL++VNGGE+F HL+R   F E+ A+FYA+++  A  YLH L +IYRDLKPENIL+D+KG++ +TDFG  K      G T T CGTPEYLAPE++  + Y+ +VDWW LG +++EM  G PPF++    ++Y+ I+   ++  ++ S   + +L  +LQ D T+R G+      DI+ H +F S +W     + +  P+ P   G  D  +FD
Sbjct:   70 KPSDFLFLKVIGKGSFGKVFLSKNKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFD 363          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Nematostella
Match: EDO38399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCY8])

HSP 1 Score: 226.483 bits (576), Expect = 2.471e-67
Identity = 123/293 (41.98%), Postives = 178/293 (60.75%), Query Frame = 2
Query:  143 DEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALH--KKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRI-KGR-TWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAA--KIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNH 1003
            DEK  +   L + E ++  S ++         L++ E++ TLGTG FGRV L  +  K  KK H +            Q EH  +EKRIL   + PF+ K+  +FKD   +YM+LE   GGE+++ LR  G F +  A+F  + VV  FEYLH   ++YRDLKPEN+L+D KGY+K+ DFGFAK+I  GR TWT CGTPEY+APEII++KG++ + D+W+LGILIFE+  G PPF +  P+K Y  I+     ++FP       ++L++ + + +   R G  ++G SDIK H
Sbjct:  301 DEKRGAKRTLDVPEEERKVSKEFAD-----LTLEDLEVVATLGTGGFGRVELVTYALKCLKKKHILDTR---------QQEHVYSEKRILMETNSPFICKIYRTFKDRKYVYMLLEACLGGELWTILRDRGTFEDATARFCIACVVEGFEYLHSKGIVYRDLKPENLLLDAKGYVKLVDFGFAKKIGSGRKTWTFCGTPEYVAPEIILNKGHDLSSDYWSLGILIFELLTGSPPFSSSDPMKTYNIILRGLDMVEFPKRIGRNPQNLIKRLCKDNPVERLGYQKDGLSDIKKH 579          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Medaka
Match: prkacaa (cAMP-dependent protein kinase catalytic subunit alpha [Source:NCBI gene;Acc:101163742])

HSP 1 Score: 521.161 bits (1341), Expect = 0.000e+0
Identity = 246/352 (69.89%), Postives = 307/352 (87.22%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGNTPT K+  +  S VK FL +AK++F  K+++P Q+T  LD FE LKTLGTGSFGRV+L  HK++ ++ A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L++SFKD SNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN+RNG +DIK H WF + DW + +++++ APFIPKC+GPGDTSNFD+YEEE +++S + KC  EF EF
Sbjct:    1 MGNTPTAKKGNEVES-VKEFLAKAKEDFLKKWENPAQQTAALDHFERLKTLGTGSFGRVMLVKHKETGQHFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVQLEHSFKDTSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLRNGVNDIKGHKWFATTDWIAIYQRKVEAPFIPKCKGPGDTSNFDDYEEEEIRVSFSEKCAKEFAEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Medaka
Match: ENSORLT00000035979.1 (cAMP-dependent protein kinase catalytic subunit beta [Source:NCBI gene;Acc:101170876])

HSP 1 Score: 515.383 bits (1326), Expect = 0.000e+0
Identity = 243/354 (68.64%), Postives = 306/354 (86.44%), Query Frame = 2
Query:  116 MGNTPTVKRDEK--DNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+  +   +++VK FL +AK++F  K++ P Q T  L++F+ +KTLGTGSFGRV+L  HK S++Y A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L+Y+FKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIK H WF + DW + +++++ APFIPKCRGPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNAATAKKGNELESDTFVKEFLAKAKEDFLRKWECPPQSTTCLEDFDRIKTLGTGSFGRVMLVKHKSSEQYFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYERKVEAPFIPKCRGPGDTSNFDDYEEEEIRVSLTEKCAKEFAEF 354          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Medaka
Match: ENSORLT00000007944.2 (protein kinase cAMP-activated catalytic subunit beta [Source:NCBI gene;Acc:101160305])

HSP 1 Score: 513.842 bits (1322), Expect = 0.000e+0
Identity = 244/352 (69.32%), Postives = 303/352 (86.08%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGNT T K+  +  S VK FL +AK++F  K++ P Q T  LD+FE  KTLGTGSFGRV+L  HK + +++A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L Y+FKDNSNLYMV+E+V GGEMFSHLRR G+FSE+HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAK++KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+RFGN++NG +DIKNH WF + DW + +++++ APF+PKCRGPGDTSNFD+YEEE + +S T KC  EF +F
Sbjct:    1 MGNTATAKKGNEQES-VKEFLAKAKEDFLRKWECPPQCTTSLDDFERFKTLGTGSFGRVMLVKHKATNQFYAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLVYAFKDNSNLYMVMEYVPGGEMFSHLRRTGRFSEHHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKKVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYERKIEAPFLPKCRGPGDTSNFDDYEEEDIHVSQTEKCGKEFADF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Medaka
Match: ENSORLT00000033457.1 (cAMP-dependent protein kinase catalytic subunit beta [Source:NCBI gene;Acc:101170876])

HSP 1 Score: 513.842 bits (1322), Expect = 0.000e+0
Identity = 244/352 (69.32%), Postives = 304/352 (86.36%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN  T K+  +  S VK FL +AK++F  K++ P Q T  L++F+ +KTLGTGSFGRV+L  HK S++Y A+K+LDK K+VKLKQ+EHTLNEKRILQA+ FPFL++L+Y+FKDNSNLYMV+E+V GGEMFSHLRR+G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID  GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIK H WF + DW + +++++ APFIPKCRGPGDTSNFD+YEEE +++S T KC  EF EF
Sbjct:    1 MGNAATAKKGNELES-VKEFLAKAKEDFLRKWECPPQSTTCLEDFDRIKTLGTGSFGRVMLVKHKSSEQYFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYERKVEAPFIPKCRGPGDTSNFDDYEEEEIRVSLTEKCAKEFAEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Medaka
Match: ENSORLT00000040218.1 (cAMP-dependent protein kinase catalytic subunit alpha [Source:NCBI gene;Acc:101160964])

HSP 1 Score: 511.916 bits (1317), Expect = 0.000e+0
Identity = 237/352 (67.33%), Postives = 307/352 (87.22%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGN PT ++  +  S VK FL +AK++F  K+++P Q T  L++FE LKTLGTGSFGRV+L  H+++ +++A+K+L+K K+VKLKQ+EHTLNEKRILQA+ FPFL++L++SFKDN+NLYMV+E+V GGEMFSHLR++G+FSE HA+FYA+Q+VL FEYLH LDLIYRDLKPEN+LID +GY+++TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+L++EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++NG +DIK H WF + DW + F+K++ APF+PK +GPGDTSNFD+YEEE +++S + KC  EF EF
Sbjct:    1 MGNAPTARKGNEMES-VKEFLAKAKEDFLKKWENPSQNTANLEQFERLKTLGTGSFGRVMLVKHRETGQHYAMKILNKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEFSFKDNTNLYMVMEYVPGGEMFSHLRKIGRFSEPHARFYATQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKGHKWFAATDWIAIFQKKVEAPFVPKFKGPGDTSNFDDYEEEEIRVSFSEKCAKEFAEF 351          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Planmine SMEST
Match: SMESG000016651.1 (SMESG000016651.1)

HSP 1 Score: 699.508 bits (1804), Expect = 0.000e+0
Identity = 352/352 (100.00%), Postives = 352/352 (100.00%), Query Frame = 2
Query:  116 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAVKVLDKLKIVKLKQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF
Sbjct:    1 MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAVKVLDKLKIVKLKQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 352          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Planmine SMEST
Match: SMESG000038292.1 (SMESG000038292.1)

HSP 1 Score: 518.85 bits (1335), Expect = 0.000e+0
Identity = 250/341 (73.31%), Postives = 300/341 (87.98%), Query Frame = 2
Query:  149 KDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +D+S VK FLEEAK+ F +K+D P Q T +L +FE L+TLGTGSFGRV+L  HK +K+Y A+K+LDK K+VKLKQVEHTLNEKRILQAI F FL++LDY FKDNSNLYMVLEFVNGGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GY+K+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++N   DIK H WF + DW + FKKEL APFIP  +GPGD+SNFD+YEEE L+I+ T KC  EF +F
Sbjct:  168 RDDS-VKAFLEEAKRLFVEKWDKPSQNTAQLSDFERLRTLGTGSFGRVMLVQHKVTKEYGAIKILDKQKVVKLKQVEHTLNEKRILQAITFMFLVRLDYHFKDNSNLYMVLEFVNGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSADLKDLLRNLLQVDLTKRYGNLKNNVGDIKTHKWFLNCDWITIFKKELEAPFIPNIKGPGDSSNFDDYEEEPLRIANTEKCLKEFADF 507          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Planmine SMEST
Match: SMESG000038292.1 (SMESG000038292.1)

HSP 1 Score: 516.924 bits (1330), Expect = 1.530e-180
Identity = 247/336 (73.51%), Postives = 296/336 (88.10%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +K FLEEAK+ F +K+D P Q T +L +FE L+TLGTGSFGRV+L  HK +K+Y A+K+LDK K+VKLKQVEHTLNEKRILQAI F FL++LDY FKDNSNLYMVLEFVNGGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GY+K+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++N   DIK H WF + DW + FKKEL APFIP  +GPGD+SNFD+YEEE L+I+ T KC  EF +F
Sbjct:  247 MKAFLEEAKRLFVEKWDKPSQNTAQLSDFERLRTLGTGSFGRVMLVQHKVTKEYGAIKILDKQKVVKLKQVEHTLNEKRILQAITFMFLVRLDYHFKDNSNLYMVLEFVNGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSADLKDLLRNLLQVDLTKRYGNLKNNVGDIKTHKWFLNCDWITIFKKELEAPFIPNIKGPGDSSNFDDYEEEPLRIANTEKCLKEFADF 582          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Planmine SMEST
Match: SMESG000038292.1 (SMESG000038292.1)

HSP 1 Score: 518.464 bits (1334), Expect = 2.050e-180
Identity = 248/336 (73.81%), Postives = 296/336 (88.10%), Query Frame = 2
Query:  164 VKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFHSFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            VK FLEEAK+ F +K+D P Q T +L +FE L+TLGTGSFGRV+L  HK +K+Y A+K+LDK K+VKLKQVEHTLNEKRILQAI F FL++LDY FKDNSNLYMVLEFVNGGEMFSHLRR+G+FSE H++FYA+Q+VLAFEYLH+LDLIYRDLKPEN+LID++GY+K+TDFGFAKR+KGRTWTLCGTPEYLAPEII+SKGYN AVDWWALG+LI+EMAAGYPPFFADQPI+IYEKIV+ K++FPSHFS +LKDLLRN+LQ DLT+R+GN++N   DIK H WF + DW + FKKEL APFIP  +GPGD+SNFD+YEEE L+I+ T KC  EF +F
Sbjct:  295 VKAFLEEAKRLFVEKWDKPSQNTAQLSDFERLRTLGTGSFGRVMLVQHKVTKEYGAIKILDKQKVVKLKQVEHTLNEKRILQAITFMFLVRLDYHFKDNSNLYMVLEFVNGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSADLKDLLRNLLQVDLTKRYGNLKNNVGDIKTHKWFLNCDWITIFKKELEAPFIPNIKGPGDSSNFDDYEEEPLRIANTEKCLKEFADF 630          
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Planmine SMEST
Match: SMESG000000892.1 (SMESG000000892.1)

HSP 1 Score: 451.825 bits (1161), Expect = 2.820e-158
Identity = 223/343 (65.01%), Postives = 279/343 (81.34%), Query Frame = 2
Query:  146 EKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKTLGTGSFGRVILALHKKSKKYHAXXXXXXXXXXXXXQVEHTLNEKRILQAIDFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYASQVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTLCGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYEKIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFH-SFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFVEF 1171
            +++N  V+ FLE A++ F DK+D P      L EF  +KTLGTG+FG VIL    ++  Y+A+KVL+K KIVK+KQVEHTLNEKRILQA++FPFL+ L YSFKDNS LY+VLE+V GGEMFSHLR+ G++SE  A FYASQVV+ FEYLH+LD++YRDLKPENILI+  GY+KITDFGFAKRIKGRTWTLCGTPEYLAPEII+SKGYN AVDWWALGILI+EM  GYPPF ADQPI IYEKIV  K KFP++ SP+ KDL+R +LQ+DLT+R+GN++NG +DIKNH WF+ + DW + +K++++ PF P+ +  GDTS FD+Y+EE LKIS   KC  EF++F
Sbjct:    8 KENNCEVEEFLENARQEFFDKWDLPVHNNATLAEFTRVKTLGTGTFGTVILVYKPQTDTYYAMKVLNKQKIVKMKQVEHTLNEKRILQAVNFPFLVNLHYSFKDNSYLYLVLEYVVGGEMFSHLRKSGRYSECQANFYASQVVMTFEYLHYLDIVYRDLKPENILINKNGYIKITDFGFAKRIKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGILIYEMIVGYPPFIADQPIHIYEKIVIGKFKFPNYVSPDAKDLIRCLLQSDLTKRYGNLKNGVADIKNHKWFYGNSDWINIYKEKILPPFKPELKSIGDTSYFDDYDEEPLKISKREKCAKEFLDF 350          
The following BLAST results are available for this feature:
BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PRKACA0.000e+069.03protein kinase cAMP-activated catalytic subunit al... [more]
PRKACA0.000e+069.03protein kinase cAMP-activated catalytic subunit al... [more]
PRKACB0.000e+069.03protein kinase cAMP-activated catalytic subunit be... [more]
PRKACA2.939e-18070.29protein kinase cAMP-activated catalytic subunit al... [more]
PRKACA2.939e-18070.29protein kinase cAMP-activated catalytic subunit al... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
kin-10.000e+072.09cAMP-dependent protein kinase catalytic subunit [... [more]
kin-10.000e+073.51cAMP-dependent protein kinase catalytic subunit [... [more]
kin-10.000e+073.21cAMP-dependent protein kinase catalytic subunit [... [more]
kin-10.000e+073.51cAMP-dependent protein kinase catalytic subunit [... [more]
kin-10.000e+073.00cAMP-dependent protein kinase catalytic subunit [... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pka-C10.000e+070.54gene:FBgn0000273 transcript:FBtr0335495[more]
Pka-C10.000e+070.54gene:FBgn0000273 transcript:FBtr0079852[more]
Pka-C10.000e+070.54gene:FBgn0000273 transcript:FBtr0079851[more]
Pka-C31.402e-11854.73gene:FBgn0000489 transcript:FBtr0075529[more]
Pka-C32.066e-11754.73gene:FBgn0000489 transcript:FBtr0075528[more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prkacbb0.000e+071.02protein kinase, cAMP-dependent, catalytic, beta b ... [more]
prkacaa0.000e+069.60protein kinase, cAMP-dependent, catalytic, alpha, ... [more]
prkacab0.000e+068.47protein kinase, cAMP-dependent, catalytic, alpha, ... [more]
prkacba1.747e-17668.73protein kinase, cAMP-dependent, catalytic, beta a ... [more]
prkacba1.747e-17668.73protein kinase, cAMP-dependent, catalytic, beta a ... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prkacb0.000e+069.89protein kinase cAMP-activated catalytic subunit be... [more]
ints80.000e+069.60integrator complex subunit 8 [Source:Xenbase;Acc:X... [more]
ints80.000e+068.16integrator complex subunit 8 [Source:Xenbase;Acc:X... [more]
ints80.000e+070.92integrator complex subunit 8 [Source:Xenbase;Acc:X... [more]
ints80.000e+071.01integrator complex subunit 8 [Source:Xenbase;Acc:X... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Prkaca0.000e+069.03protein kinase, cAMP dependent, catalytic, alpha [... [more]
Prkaca0.000e+070.83protein kinase, cAMP dependent, catalytic, alpha [... [more]
Prkacb1.526e-18069.03protein kinase, cAMP dependent, catalytic, beta [S... [more]
Prkacb8.482e-17870.54protein kinase, cAMP dependent, catalytic, beta [S... [more]
Prkacb3.126e-17770.24protein kinase, cAMP dependent, catalytic, beta [S... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P12370|KAPC1_DROME0.000e+070.54cAMP-dependent protein kinase catalytic subunit 1 ... [more]
sp|P05132|KAPCA_MOUSE0.000e+069.03cAMP-dependent protein kinase catalytic subunit al... [more]
sp|P36887|KAPCA_PIG0.000e+069.32cAMP-dependent protein kinase catalytic subunit al... [more]
sp|P27791|KAPCA_RAT0.000e+069.03cAMP-dependent protein kinase catalytic subunit al... [more]
sp|P17612|KAPCA_HUMAN0.000e+069.03cAMP-dependent protein kinase catalytic subunit al... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0X3NYD40.000e+074.15cAMP-dependent protein kinase catalytic subunit al... [more]
D2JWR50.000e+073.58cAMP-dependent protein kinase catalytic subunit OS... [more]
A0A1S3JGB80.000e+072.24cAMP-dependent protein kinase catalytic subunit is... [more]
D2JVC20.000e+073.01cAMP-dependent protein kinase catalytic subunit OS... [more]
C7DPD50.000e+073.30Serine/threonine kinase; cAMP-dependent protein ki... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prkacaa0.000e+069.89cAMP-dependent protein kinase catalytic subunit al... [more]
prkacab0.000e+068.75cAMP-dependent protein kinase catalytic subunit al... [more]
ENSAMXT00000050353.10.000e+070.17protein kinase cAMP-activated catalytic subunit be... [more]
prkacbb0.000e+070.17cAMP-dependent protein kinase catalytic subunit be... [more]
ENSAMXT00000056663.10.000e+071.73protein kinase cAMP-activated catalytic subunit be... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000001814.15.545e-16476.03pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gen... [more]
ENSPMAT00000002200.14.899e-8040.88pep scaffold:Pmarinus_7.0:GL479132:31244:36905:-1 ... [more]
ENSPMAT00000004852.11.504e-7470.24pep scaffold:Pmarinus_7.0:GL488704:3417:7135:1 gen... [more]
ENSPMAT00000008480.18.951e-7340.71pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1... [more]
ENSPMAT00000006766.13.437e-7239.20pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 g... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
TPK26.591e-10952.17cAMP-dependent protein kinase catalytic subunit; p... [more]
TPK35.523e-10450.51cAMP-dependent protein kinase catalytic subunit; p... [more]
TPK11.562e-10349.83cAMP-dependent protein kinase catalytic subunit; p... [more]
YPK11.538e-8441.52S/T protein kinase; phosphorylates, downregulates ... [more]
YPK28.261e-8341.52Protein kinase similar to S/T protein kinase Ypk1p... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO352283.209e-11252.16Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO411661.966e-7639.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO384072.539e-7639.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO378001.322e-7541.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO383992.471e-6741.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prkacaa0.000e+069.89cAMP-dependent protein kinase catalytic subunit al... [more]
ENSORLT00000035979.10.000e+068.64cAMP-dependent protein kinase catalytic subunit be... [more]
ENSORLT00000007944.20.000e+069.32protein kinase cAMP-activated catalytic subunit be... [more]
ENSORLT00000033457.10.000e+069.32cAMP-dependent protein kinase catalytic subunit be... [more]
ENSORLT00000040218.10.000e+067.33cAMP-dependent protein kinase catalytic subunit al... [more]
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BLAST of cAMP-dependent protein kinase catalytic subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016651.10.000e+0100.00SMESG000016651.1[more]
SMESG000038292.10.000e+073.31SMESG000038292.1[more]
SMESG000038292.11.530e-18073.51SMESG000038292.1[more]
SMESG000038292.12.050e-18073.81SMESG000038292.1[more]
SMESG000000892.12.820e-15865.01SMESG000000892.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034681 ID=SMED30034681|Name=cAMP-dependent protein kinase catalytic subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=1341bp
TAGTTTAAGAGAATCGAAATATTAGTACTTTAAATTAAAAAAATTTAAAT
CAAGGTCATATGTGCTTTTGAAAAATAGTGCTTGAATTTTCTATTAAATC
TCAGTTTATCCACTTATGGGTAACACACCTACTGTAAAACGAGATGAAAA
AGATAATTCTTATGTAAAATTGTTTCTGGAAGAAGCCAAAAAAAATTTTT
CCGATAAATATGATCATCCAAAACAAGAAACCTACAAATTAGATGAATTT
GAAATTTTAAAGACTCTTGGAACTGGATCATTTGGTAGAGTAATTTTAGC
ACTGCATAAAAAATCTAAAAAATATCATGCTGTTAAAGTTCTTGACAAAC
TAAAAATTGTGAAACTGAAACAAGTTGAACATACTTTAAATGAAAAGCGT
ATTTTACAAGCAATTGACTTTCCATTTCTGATAAAATTGGATTACAGCTT
CAAAGACAATAGTAATCTTTATATGGTACTGGAATTCGTGAATGGAGGTG
AAATGTTTTCTCATCTACGACGAGTGGGCAAATTTAGTGAGAATCACGCC
AAGTTTTATGCCAGTCAAGTGGTGTTGGCATTTGAGTATTTGCACCATTT
GGATCTGATTTATCGTGATCTGAAACCAGAGAATATTTTGATAGATACTA
AAGGATATCTCAAAATTACAGATTTTGGCTTCGCAAAACGAATCAAAGGC
AGGACATGGACGTTATGTGGAACTCCAGAATATTTAGCACCTGAAATAAT
TATGAGCAAAGGTTACAACAATGCAGTAGATTGGTGGGCATTGGGGATAT
TAATATTCGAAATGGCTGCGGGCTATCCACCTTTTTTTGCTGATCAACCG
ATAAAGATCTATGAGAAAATAGTAGCAGCTAAAATCAAGTTTCCTTCTCA
TTTTTCGCCAGAATTAAAAGATTTACTACGTAATATTTTGCAAACAGATT
TAACGAGACGCTTTGGCAATATGAGAAATGGAGCTAGTGATATTAAAAAT
CATGTTTGGTTTCATTCATTCGATTGGTATTCTGCCTTCAAAAAAGAATT
AATTGCACCCTTTATTCCTAAATGCCGTGGGCCTGGAGATACAAGCAATT
TTGACAATTATGAAGAAGAAGTTTTGAAAATATCTACAACCTGTAAATGT
ACTGACGAATTTGTAGAATTTTAGATGGAATCGGAGAAAATGCTATTTTT
ATAAATTTGTGAATAATTATGTGCAGAAATATAGTTTTGTTATTCACTCA
ATAAATTTCTGCAGAACTTTGATCGCAAGTTGAAATATTTAAACTTGTTT
ATCTTTGATTAATATTATATATTTTGCTTGATCAGTTTACC
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protein sequence of SMED30034681-orf-1

>SMED30034681-orf-1 ID=SMED30034681-orf-1|Name=SMED30034681-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=353bp
MGNTPTVKRDEKDNSYVKLFLEEAKKNFSDKYDHPKQETYKLDEFEILKT
LGTGSFGRVILALHKKSKKYHAVKVLDKLKIVKLKQVEHTLNEKRILQAI
DFPFLIKLDYSFKDNSNLYMVLEFVNGGEMFSHLRRVGKFSENHAKFYAS
QVVLAFEYLHHLDLIYRDLKPENILIDTKGYLKITDFGFAKRIKGRTWTL
CGTPEYLAPEIIMSKGYNNAVDWWALGILIFEMAAGYPPFFADQPIKIYE
KIVAAKIKFPSHFSPELKDLLRNILQTDLTRRFGNMRNGASDIKNHVWFH
SFDWYSAFKKELIAPFIPKCRGPGDTSNFDNYEEEVLKISTTCKCTDEFV
EF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0007186G-protein coupled receptor signaling pathway
GO:0010737protein kinase A signaling
GO:0071333cellular response to glucose stimulus
GO:0006468protein phosphorylation
GO:0007228positive regulation of hh target transcription factor activity
GO:0007314oocyte anterior/posterior axis specification
GO:0007317regulation of pole plasm oskar mRNA localization
GO:0007448anterior/posterior pattern specification, imaginal disc
GO:0007476imaginal disc-derived wing morphogenesis
GO:0007480imaginal disc-derived leg morphogenesis
GO:0007611learning or memory
GO:0007612learning
GO:0007613memory
GO:0007615anesthesia-resistant memory
GO:0007622rhythmic behavior
GO:0008103oocyte microtubule cytoskeleton polarization
GO:0008355olfactory learning
GO:0008359regulation of bicoid mRNA localization
GO:0016310phosphorylation
GO:0019933cAMP-mediated signaling
GO:0040040thermosensory behavior
GO:0042981regulation of apoptotic process
GO:0045187regulation of circadian sleep/wake cycle, sleep
GO:0045475locomotor rhythm
GO:0045879negative regulation of smoothened signaling pathway
GO:0048149behavioral response to ethanol
GO:0048477oogenesis
GO:0048682sprouting of injured axon
GO:0048749compound eye development
GO:0050804modulation of synaptic transmission
Vocabulary: molecular function
TermDefinition
GO:0034237protein kinase A regulatory subunit binding
GO:0004674protein serine/threonine kinase activity
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004691cAMP-dependent protein kinase activity
GO:0005515protein binding
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000018Category 4 cell
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR039035PKA_C-alpha
IPR000961AGC-kinase_C
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005886plasma membrane
GO:0005952cAMP-dependent protein kinase complex
GO:0030425dendrite
GO:0044297cell body
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000961AGC-kinase, C-terminalSMARTSM00133pkinase_C_6coord: 300..352
e-value: 4.7E-7
score: 39.5
IPR000961AGC-kinase, C-terminalPROSITEPS51285AGC_KINASE_CTERcoord: 300..352
score: 11.407
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 45..299
e-value: 3.8E-102
score: 355.3
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 45..299
e-value: 1.3E-72
score: 244.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 45..299
score: 49.46
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 42..330
e-value: 2.2E-125
score: 419.4
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 129..319
e-value: 2.2E-125
score: 419.4
NoneNo IPR availablePIRSFPIRSF000654ILKcoord: 21..288
e-value: 4.2E-29
score: 99.1
NoneNo IPR availablePANTHERPTHR24353CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASEcoord: 9..352
NoneNo IPR availableCDDcd14209STKc_PKAcoord: 43..332
e-value: 0.0
score: 558.558
IPR039035cAMP-dependent protein kinase catalytic subunit alphaPANTHERPTHR24353:SF82CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHAcoord: 9..352
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 164..176
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 31..339