Tissue factor pathway inhibitor

Overview


Name	Tissue factor pathway inhibitor
Smed ID	SMED30034647
Length (bp)	324

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Tissue factor pathway inhibitor (SMED30034647) t-SNE clustered cells

Violin plots show distribution of expression levels for Tissue factor pathway inhibitor (SMED30034647) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tissue factor pathway inhibitor (SMED30034647) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tissue factor pathway inhibitor (SMED30034647) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30034647

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
prepharyngeal region	SMED30034647	SmedASXL_004371	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
gut	SMED30034647	dd_Smed_v4_412_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
tail region	SMED30034647	dd_Smed_v6_412_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: TFPI (tissue factor pathway inhibitor [Source:HGNC Symbol;Acc:HGNC:11760])

HSP 1 Score: 61.6178 bits (148), Expect = 4.117e-13
Identity = 27/53 (50.94%), Postives = 35/53 (66.04%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            C  + D GPC+A    FFFN  T +CEEF+YGGC GN N F + EEC++ C +
Sbjct:   54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTR 106

[Close]

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            C  + D GPC+A    FFFN  T +CEEF+YGGC GN N F + EEC++ C +
Sbjct:   54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTR 106

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: TFPI (tissue factor pathway inhibitor [Source:HGNC Symbol;Acc:HGNC:11760])

HSP 1 Score: 61.2326 bits (147), Expect = 5.682e-13
Identity = 27/51 (52.94%), Postives = 34/51 (66.67%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C  + D GPC+A    FFFN  T +CEEF+YGGC GN N F + EEC++ C
Sbjct:   54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMC 104

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30916])

HSP 1 Score: 63.5438 bits (153), Expect = 1.836e-12
Identity = 26/51 (50.98%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C L   QGPC+A  P + +N++TG+C+ FVYGGC GN N F + E C+E+C
Sbjct:  293 CSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 343

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30916])

HSP 1 Score: 63.1586 bits (152), Expect = 2.147e-12
Identity = 26/51 (50.98%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C L   QGPC+A  P + +N++TG+C+ FVYGGC GN N F + E C+E+C
Sbjct:  386 CSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 436

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mig-6 (Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840])

HSP 1 Score: 62.3882 bits (150), Expect = 1.705e-12
Identity = 28/57 (49.12%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
             K  C L   QGPC      +++NT + +CE F YGGCLGN N F T EECQ  C K
Sbjct: 1500 HKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPK 1556

HSP 2 Score: 53.5286 bits (127), Expect = 2.295e-9
Identity = 22/51 (43.14%), Postives = 32/51 (62.75%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C LE   GPC  +  M++F++    C+ F YGGC GN N F + E+CQ++C
Sbjct: 1853 CTLERSAGPCTDSISMWYFDSTHLDCKPFTYGGCRGNQNRFVSKEQCQQSC 1903

HSP 3 Score: 50.0618 bits (118), Expect = 3.047e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            ++  C L +DQG C+ AF  +++   TG C  F Y GC GN N F + ++C+  C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 4 Score: 47.7506 bits (112), Expect = 1.969e-7
Identity = 21/51 (41.18%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C    D GPC      +F+N  + +CE F YGGC GN N F + +EC++ C
Sbjct: 1271 CRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

[Close]

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
             K  C L   QGPC      +++NT + +CE F YGGCLGN N F T EECQ  C K
Sbjct: 1500 HKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPK 1556

HSP 2 Score: 53.5286 bits (127), Expect = 2.295e-9
Identity = 22/51 (43.14%), Postives = 32/51 (62.75%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C LE   GPC  +  M++F++    C+ F YGGC GN N F + E+CQ++C
Sbjct: 1853 CTLERSAGPCTDSISMWYFDSTHLDCKPFTYGGCRGNQNRFVSKEQCQQSC 1903

HSP 3 Score: 50.0618 bits (118), Expect = 3.047e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            ++  C L +DQG C+ AF  +++   TG C  F Y GC GN N F + ++C+  C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 4 Score: 47.7506 bits (112), Expect = 1.969e-7
Identity = 21/51 (41.18%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C    D GPC      +F+N  + +CE F YGGC GN N F + +EC++ C
Sbjct: 1271 CRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mig-6 (Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840])

HSP 1 Score: 60.4622 bits (145), Expect = 8.562e-12
Identity = 27/55 (49.09%), Postives = 32/55 (58.18%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             K  C L   QGPC      +++NT + +CE F YGGCLGN N F T EECQ  C
Sbjct: 1500 HKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARC 1554

HSP 2 Score: 49.6766 bits (117), Expect = 4.953e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            ++  C L +DQG C+ AF  +++   TG C  F Y GC GN N F + ++C+  C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 3 Score: 47.3654 bits (111), Expect = 2.877e-7
Identity = 21/51 (41.18%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C    D GPC      +F+N  + +CE F YGGC GN N F + +EC++ C
Sbjct: 1271 CRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

[Close]

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             K  C L   QGPC      +++NT + +CE F YGGCLGN N F T EECQ  C
Sbjct: 1500 HKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARC 1554

HSP 2 Score: 49.6766 bits (117), Expect = 4.953e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            ++  C L +DQG C+ AF  +++   TG C  F Y GC GN N F + ++C+  C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 3 Score: 47.3654 bits (111), Expect = 2.877e-7
Identity = 21/51 (41.18%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C    D GPC      +F+N  + +CE F YGGC GN N F + +EC++ C
Sbjct: 1271 CRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

[Close]

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             K  C L   QGPC      +++NT + +CE F YGGCLGN N F T EECQ  C
Sbjct: 1500 HKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARC 1554

HSP 2 Score: 49.6766 bits (117), Expect = 4.953e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   91 RKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            ++  C L +DQG C+ AF  +++   TG C  F Y GC GN N F + ++C+  C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 3 Score: 47.3654 bits (111), Expect = 2.877e-7
Identity = 21/51 (41.18%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C    D GPC      +F+N  + +CE F YGGC GN N F + +EC++ C
Sbjct: 1271 CRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: CG10031 (gene:FBgn0031563 transcript:FBtr0077544)

HSP 1 Score: 63.5438 bits (153), Expect = 5.698e-14
Identity = 25/53 (47.17%), Postives = 35/53 (66.04%), Query Frame = 1

Query:   97 PECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            P+CL  +D GPCR +   F++N ++  CE F YGGC GNDN +G  + C+E C
Sbjct:   73 PKCLQPLDVGPCRMSLERFYYNKDSKACETFKYGGCRGNDNRWGFRQTCEEAC 125

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: CG17380 (gene:FBgn0039077 transcript:FBtr0299867)

HSP 1 Score: 55.8398 bits (133), Expect = 4.678e-11
Identity = 28/71 (39.44%), Postives = 37/71 (52.11%), Query Frame = 1

Query:   31 MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEEC 243
            MN +  F IF+I        R   C    + GPC+  F MF ++ +   C EF+YGGC GN N F T +EC
Sbjct:    1 MNSLHYFLIFLIVPGTSTALRHERCSFIANPGPCKGNFEMFAYDMDNNVCVEFIYGGCGGNPNRFQTKKEC 71

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: CG13748 (gene:FBgn0033355 transcript:FBtr0088656)

HSP 1 Score: 55.0694 bits (131), Expect = 8.095e-11
Identity = 23/52 (44.23%), Postives = 33/52 (63.46%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            CL+   +G CRA  P + ++ E  KC EF +GGC GN+N F +Y++C   CE
Sbjct:   60 CLMPARKGVCRALIPRWRYDPEQKKCVEFKFGGCDGNENNFASYKDCMSTCE 111

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: IM33 (gene:FBgn0031561 transcript:FBtr0077546)

HSP 1 Score: 51.6026 bits (122), Expect = 8.150e-10
Identity = 28/82 (34.15%), Postives = 40/82 (48.78%), Query Frame = 1

Query:   31 MNFIITFSIFVIFAIQFIECRKPECLLEMDQG-----PCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            M FI    +        +  + P C L           C A  P F ++ ET  CE+F+YGGC GN+N FGT E C++ C++
Sbjct:    1 MKFIAAVCLMFALVAVALGLKDPICGLPAGIDGNGLIKCAAFIPSFSYHPETNSCEKFIYGGCGGNENRFGTQELCEQKCKE 82

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: IM33 (gene:FBgn0031561 transcript:FBtr0345610)

HSP 1 Score: 51.6026 bits (122), Expect = 8.150e-10
Identity = 28/82 (34.15%), Postives = 40/82 (48.78%), Query Frame = 1

Query:   31 MNFIITFSIFVIFAIQFIECRKPECLLEMDQG-----PCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            M FI    +        +  + P C L           C A  P F ++ ET  CE+F+YGGC GN+N FGT E C++ C++
Sbjct:    1 MKFIAAVCLMFALVAVALGLKDPICGLPAGIDGNGLIKCAAFIPSFSYHPETNSCEKFIYGGCGGNENRFGTQELCEQKCKE 82

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: spint2 (serine peptidase inhibitor, Kunitz type, 2 [Source:ZFIN;Acc:ZDB-GENE-061013-323])

HSP 1 Score: 63.1586 bits (152), Expect = 1.225e-12
Identity = 26/52 (50.00%), Postives = 35/52 (67.31%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +C++  D GPCRA+F MFFF   +  C+ F+YGGC GN N +G+ EEC   C
Sbjct:  303 KCVVPSDSGPCRASFRMFFFEASSQSCQPFIYGGCRGNLNRYGSEEECMSVC 354

HSP 2 Score: 51.9878 bits (123), Expect = 1.063e-8
Identity = 25/57 (43.86%), Postives = 34/57 (59.65%), Query Frame = 1

Query:   85 ECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             CR P  +     G CRAAFP FF++     C+ F+YGGC GN+N F +  EC+ +C
Sbjct:  132 HCRFPSAV-----GNCRAAFPRFFYDITDQTCKSFIYGGCGGNENNFYSQAECEASC 183

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: spint2 (serine peptidase inhibitor, Kunitz type, 2 [Source:ZFIN;Acc:ZDB-GENE-061013-323])

HSP 1 Score: 63.1586 bits (152), Expect = 1.237e-12
Identity = 26/52 (50.00%), Postives = 35/52 (67.31%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +C++  D GPCRA+F MFFF   +  C+ F+YGGC GN N +G+ EEC   C
Sbjct:  303 KCVVPSDSGPCRASFRMFFFEASSQSCQPFIYGGCRGNLNRYGSEEECMSVC 354

HSP 2 Score: 51.9878 bits (123), Expect = 1.032e-8
Identity = 25/57 (43.86%), Postives = 34/57 (59.65%), Query Frame = 1

Query:   85 ECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             CR P  +     G CRAAFP FF++     C+ F+YGGC GN+N F +  EC+ +C
Sbjct:  132 HCRFPSAV-----GNCRAAFPRFFYDITDQTCKSFIYGGCGGNENNFYSQAECEASC 183

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: wu:fb59d01 (wu:fb59d01 [Source:ZFIN;Acc:ZDB-GENE-030131-1098])

HSP 1 Score: 61.2326 bits (147), Expect = 2.638e-12
Identity = 26/51 (50.98%), Postives = 34/51 (66.67%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C +EMD+G C A FPM+++N E   C  F+Y GC GN N F + EECQ+ C
Sbjct:   93 CSMEMDEGTCFALFPMYYYNAEEKICRMFIYRGCRGNANRFESREECQQTC 143

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: tfpia (tissue factor pathway inhibitor a [Source:ZFIN;Acc:ZDB-GENE-030711-1])

HSP 1 Score: 61.2326 bits (147), Expect = 4.134e-12
Identity = 26/51 (50.98%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C L+ D+GPC+A    F+F+ +TG+CE F YGGC GN N F T ++C+E C
Sbjct:   42 CALKKDEGPCKAMKDRFYFDIDTGRCEPFEYGGCQGNANNFETLQDCEEMC 92

HSP 2 Score: 59.6918 bits (143), Expect = 1.529e-11
Identity = 25/55 (45.45%), Postives = 36/55 (65.45%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            K  C LE + GPCR   P +FF+ ++ +C++F YGGC GN N F T + CQ+ C+
Sbjct:   98 KSPCHLEDEPGPCRGLVPRYFFDQKSQECKQFFYGGCFGNANNFKTIKACQQRCQ 152

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: tfpia (tissue factor pathway inhibitor a [Source:ZFIN;Acc:ZDB-GENE-030711-1])

HSP 1 Score: 61.2326 bits (147), Expect = 4.151e-12
Identity = 26/51 (50.98%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C L+ D+GPC+A    F+F+ +TG+CE F YGGC GN N F T ++C+E C
Sbjct:   41 CALKKDEGPCKAMKDRFYFDIDTGRCEPFEYGGCQGNANNFETLQDCEEMC 91

HSP 2 Score: 59.6918 bits (143), Expect = 1.475e-11
Identity = 25/55 (45.45%), Postives = 36/55 (65.45%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            K  C LE + GPCR   P +FF+ ++ +C++F YGGC GN N F T + CQ+ C+
Sbjct:   97 KSPCHLEDEPGPCRGLVPRYFFDQKSQECKQFFYGGCFGNANNFKTIKACQQRCQ 151

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:NCBI gene;Acc:548483])

HSP 1 Score: 59.6918 bits (143), Expect = 1.306e-11
Identity = 25/53 (47.17%), Postives = 37/53 (69.81%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            CLL  D+GPC+A  P ++++  T  C+EF+YGGC GN N F + E+C++ C K
Sbjct:   29 CLLPPDEGPCKALIPHYYYDRYTQTCQEFLYGGCDGNSNKFLSMEDCEKFCWK 81

HSP 2 Score: 54.299 bits (129), Expect = 1.344e-9
Identity = 23/52 (44.23%), Postives = 31/52 (59.62%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C ++ D+GPCR     + +N +T KCE+F YGGC GNDN F     C + C 
Sbjct:   89 CRMDPDEGPCRGFLKRYAYNMQTMKCEQFYYGGCYGNDNNFKDKASCMDFCS 140

HSP 3 Score: 51.6026 bits (122), Expect = 1.440e-8
Identity = 24/53 (45.28%), Postives = 31/53 (58.49%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            C    D+G C A+   ++FN E+  CEEFVY GC GN N F   E+C   C+K
Sbjct:  149 CYSPKDEGSCSASVTRYYFNIESKACEEFVYTGCGGNSNNFVKMEDCDSVCKK 201

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: rlbp1 (retinaldehyde binding protein 1 [Source:Xenbase;Acc:XB-GENE-976303])

HSP 1 Score: 58.9214 bits (141), Expect = 6.853e-11
Identity = 25/57 (43.86%), Postives = 31/57 (54.39%), Query Frame = 1

Query:   88 CRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C    C+   D GPCRA+F  F+++    KC  F YGGC GNDN F    +C   CE
Sbjct:  353 CENSRCVDLPDTGPCRASFSRFYYDPNIRKCLRFTYGGCAGNDNNFHRESDCMRYCE 409

HSP 2 Score: 49.6766 bits (117), Expect = 1.099e-7
Identity = 21/51 (41.18%), Postives = 28/51 (54.90%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C      G CR +F  ++FN ET  C EF YGGC  N N +   E+C++ C
Sbjct:  240 CFAPHKVGRCRGSFTRWYFNPETNDCLEFTYGGCKPNKNNYLRIEDCRQTC 290

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: rlbp1 (retinaldehyde binding protein 1 [Source:Xenbase;Acc:XB-GENE-976303])

HSP 1 Score: 56.9954 bits (136), Expect = 2.460e-10
Identity = 25/55 (45.45%), Postives = 31/55 (56.36%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            K  C+   D GPCRA+F  F+++    KC  F YGGC GNDN F    +C   CE
Sbjct:  372 KARCVDLPDTGPCRASFSRFYYDPNIRKCLRFTYGGCAGNDNNFHRESDCMRYCE 426

HSP 2 Score: 49.6766 bits (117), Expect = 1.204e-7
Identity = 21/51 (41.18%), Postives = 28/51 (54.90%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C      G CR +F  ++FN ET  C EF YGGC  N N +   E+C++ C
Sbjct:  240 CFAPHKVGRCRGSFTRWYFNPETNDCLEFTYGGCKPNKNNYLRIEDCRQTC 290

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: ric8a (RIC8 guanine nucleotide exchange factor A [Source:Xenbase;Acc:XB-GENE-5745094])

HSP 1 Score: 53.5286 bits (127), Expect = 2.805e-10
Identity = 22/53 (41.51%), Postives = 32/53 (60.38%), Query Frame = 1

Query:   97 PECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
              C L +DQGPCR     ++++ +   C +F +GGC GN N F T EEC++ C
Sbjct:   11 ARCTLILDQGPCRTYIIKWYYDKQANSCAQFWFGGCNGNSNRFDTEEECKKIC 63

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: rlbp1 (retinaldehyde binding protein 1 [Source:Xenbase;Acc:XB-GENE-976303])

HSP 1 Score: 56.9954 bits (136), Expect = 3.003e-10
Identity = 25/55 (45.45%), Postives = 31/55 (56.36%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            K  C+   D GPCRA+F  F+++    KC  F YGGC GNDN F    +C   CE
Sbjct:  372 KARCVDLPDTGPCRASFSRFYYDPNIRKCLRFTYGGCAGNDNNFHRESDCMRYCE 426

HSP 2 Score: 49.2914 bits (116), Expect = 1.414e-7
Identity = 21/51 (41.18%), Postives = 28/51 (54.90%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C      G CR +F  ++FN ET  C EF YGGC  N N +   E+C++ C
Sbjct:  240 CFAPHKVGRCRGSFTRWYFNPETNDCLEFTYGGCKPNKNNYLRIEDCRQTC 290

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: Tfpi (tissue factor pathway inhibitor [Source:MGI Symbol;Acc:MGI:1095418])

HSP 1 Score: 65.0846 bits (157), Expect = 1.319e-13
Identity = 27/51 (52.94%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C ++ D GPC+A    +FFN  T +CEEF+YGGC GN+N F T EEC++ C
Sbjct:   50 CAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 60.4622 bits (145), Expect = 6.984e-12
Identity = 27/52 (51.92%), Postives = 34/52 (65.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C LE D G CR     + +N +T +CE FVYGGCLGN N F T +EC++ CE
Sbjct:  121 CFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C ++ D GPC+A    +FFN  T +CEEF+YGGC GN+N F T EEC++ C
Sbjct:   50 CAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 60.4622 bits (145), Expect = 6.984e-12
Identity = 27/52 (51.92%), Postives = 34/52 (65.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C LE D G CR     + +N +T +CE FVYGGCLGN N F T +EC++ CE
Sbjct:  121 CFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C ++ D GPC+A    +FFN  T +CEEF+YGGC GN+N F T EEC++ C
Sbjct:   50 CAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 60.4622 bits (145), Expect = 6.984e-12
Identity = 27/52 (51.92%), Postives = 34/52 (65.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C LE D G CR     + +N +T +CE FVYGGCLGN N F T +EC++ CE
Sbjct:  121 CFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: Spint3 (serine peptidase inhibitor, Kunitz type, 3 [Source:MGI Symbol;Acc:MGI:3651470])

HSP 1 Score: 61.6178 bits (148), Expect = 1.771e-13
Identity = 27/53 (50.94%), Postives = 36/53 (67.92%), Query Frame = 1

Query:   97 PECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            P C+L  D G CRA F  +++N++TGKCE F YGGC GN+N F +  +CQ  C
Sbjct:   33 PMCILPKDIGGCRAVFVRWYYNSKTGKCEWFRYGGCKGNENNFPSRSQCQAVC 85

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: Tfpi (tissue factor pathway inhibitor [Source:MGI Symbol;Acc:MGI:1095418])

HSP 1 Score: 64.6994 bits (156), Expect = 1.774e-13
Identity = 27/51 (52.94%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C ++ D GPC+A    +FFN  T +CEEF+YGGC GN+N F T EEC++ C
Sbjct:   50 CAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 60.077 bits (144), Expect = 8.719e-12
Identity = 27/52 (51.92%), Postives = 34/52 (65.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C LE D G CR     + +N +T +CE FVYGGCLGN N F T +EC++ CE
Sbjct:  121 CFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|Q9TWG0|VKT1_ANESU (KappaPI-actitoxin-Avd3b OS=Anemonia sulcata OX=6108 PE=1 SV=1)

HSP 1 Score: 67.3958 bits (163), Expect = 2.849e-15
Identity = 27/52 (51.92%), Postives = 39/52 (75.00%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +CLL MD G CRA+ P +++N+ + +CE+F+YGGC GN N F T EEC++ C
Sbjct:    4 DCLLPMDVGRCRASHPRYYYNSSSKRCEKFIYGGCRGNANNFHTLEECEKVC 55

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P0DMJ2|VKT3C_ACTEQ (PI-actitoxin-Aeq3c OS=Actinia equina OX=6106 PE=1 SV=1)

HSP 1 Score: 67.3958 bits (163), Expect = 3.421e-15
Identity = 29/51 (56.86%), Postives = 38/51 (74.51%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            CLL M  GPCRAA+P +++N+++ KCEEF YGGC  N N F T EEC++ C
Sbjct:    7 CLLPMKVGPCRAAWPSYYYNSKSEKCEEFTYGGCDANANNFQTEEECKKAC 57

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P0DN06|VKT1A_ANEVI (U-actitoxin-Avd3f OS=Anemonia viridis OX=51769 PE=3 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 4.416e-15
Identity = 27/52 (51.92%), Postives = 39/52 (75.00%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +CLL MD G CRA+ P +++N+ + +CE+F+YGGC GN N F T EEC++ C
Sbjct:   20 DCLLPMDVGRCRASHPRYYYNSSSKRCEKFIYGGCRGNANNFHTLEECEKVC 71

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P81547|VKT1_ANTAF (PI-actitoxin-Axm2a OS=Anthopleura aff. xanthogrammica OX=152178 PE=1 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 6.596e-15
Identity = 28/53 (52.83%), Postives = 36/53 (67.92%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            +CLL    GPCRAA P F++N+++GKCE F YGGC  N N F T +EC+  C 
Sbjct:    6 DCLLPKKVGPCRAAVPRFYYNSDSGKCEGFTYGGCHANANNFKTKDECKNACH 58

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P0DN19|VKTF_ANEVI (U-actitoxin-Avd3r (Fragment) OS=Anemonia viridis OX=51769 PE=2 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 1.028e-14
Identity = 28/52 (53.85%), Postives = 38/52 (73.08%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +CLL MD G CRA FP +++N+ + +CE+F YGGC GN N F T EEC++ C
Sbjct:   10 DCLLPMDVGRCRAKFPRYYYNSSSRRCEKFNYGGCRGNANNFHTLEECEKVC 61

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: C3ZCN3 (BPTI/Kunitz inhibitor domain-containing protein (Fragment) OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_199584 PE=4 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 2.072e-16
Identity = 33/53 (62.26%), Postives = 42/53 (79.25%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            C   MD GPC+AAFP ++FN++TG+CE+F+YGGCLGNDN F T +ECQ  C K
Sbjct:    1 CEQAMDPGPCKAAFPRWYFNSQTGQCEQFIYGGCLGNDNNFVTEQECQTTCGK 53

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: I1ZII0 (Serine protease inhibitor-1 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 1.044e-15
Identity = 32/73 (43.84%), Postives = 48/73 (65.75%), Query Frame = 1

Query:   43 ITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            I F +  I   + I C    C L  + GPC+A FP +++N++TGKCE+F+YGGC GN N F + ++C++NC K
Sbjct:    3 ILFILLCICVFENISCLNSICSLPKNAGPCKAYFPRYYYNSKTGKCEKFIYGGCKGNQNNFQSSKDCEQNCHK 75

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A3Q3KHW0 (BPTI/Kunitz inhibitor domain-containing protein OS=Monopterus albus OX=43700 PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 1.141e-15
Identity = 33/59 (55.93%), Postives = 43/59 (72.88%), Query Frame = 1

Query:   79 FIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +I   KP CLL++D GPCRAA   +++NT T KCE F YGGC GN N F +Y+ECQ++C
Sbjct:    3 YISSGKPACLLQVDDGPCRAAIERYYYNTFTQKCEIFYYGGCKGNANNFNSYQECQKSC 61

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A3Q1AGU6 (Uncharacterized protein OS=Amphiprion ocellaris OX=80972 PE=4 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 1.181e-15
Identity = 35/85 (41.18%), Postives = 53/85 (62.35%), Query Frame = 1

Query:    4 TFSNKKITKMNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            T+   K  K N++   S  V  + ++  C    CL+  D GPCRAAFPMF++N ++  C+ F+YGGC GN+N +G+ EEC ++C 
Sbjct:  102 TYGGCKGNKNNYVDEESCMVTCSGKYCTCVC-HCLVSPDPGPCRAAFPMFYYNPDSASCQSFIYGGCRGNENRYGSVEECMDHCS 185

HSP 2 Score: 63.5438 bits (153), Expect = 9.950e-10
Identity = 32/73 (43.84%), Postives = 42/73 (57.53%), Query Frame = 1

Query:   40 IITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            +  + + V+F +  ++CR P     M  GPCRAAFP FF+N     C  FVYGGC  N N F T EEC+ +C 
Sbjct:    1 MPVYCVSVVFLLS-VDCRLP-----MKVGPCRAAFPRFFYNPTNQSCSSFVYGGCESNRNNFLTLEECESSCS 67

HSP 3 Score: 53.9138 bits (128), Expect = 3.731e-6
Identity = 23/53 (43.40%), Postives = 30/53 (56.60%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
             C  E+  GPCRAAF  ++++ E G C+ F YGGC GN N +   E C   C 
Sbjct:   72 HCEAELQVGPCRAAFRRWYYDREAGSCQSFTYGGCKGNKNNYVDEESCMVTCS 124

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A3Q1AGY5 (Uncharacterized protein OS=Amphiprion ocellaris OX=80972 PE=4 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 1.374e-15
Identity = 35/85 (41.18%), Postives = 53/85 (62.35%), Query Frame = 1

Query:    4 TFSNKKITKMNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            T+   K  K N++   S  V  + ++  C    CL+  D GPCRAAFPMF++N ++  C+ F+YGGC GN+N +G+ EEC ++C 
Sbjct:  107 TYGGCKGNKNNYVDEESCMVTCSGKYCTCVC-HCLVSPDPGPCRAAFPMFYYNPDSASCQSFIYGGCRGNENRYGSVEECMDHCS 190

HSP 2 Score: 63.929 bits (154), Expect = 8.035e-10
Identity = 32/73 (43.84%), Postives = 42/73 (57.53%), Query Frame = 1

Query:   40 IITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            +  + + V+F +  ++CR P     M  GPCRAAFP FF+N     C  FVYGGC  N N F T EEC+ +C 
Sbjct:    1 MPVYCVSVVFLLS-VDCRLP-----MKVGPCRAAFPRFFYNPTNQSCSSFVYGGCESNRNNFLTLEECESSCS 67

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: col28a2b (collagen, type XXVIII, alpha 2b [Source:ZFIN;Acc:ZDB-GENE-130530-762])

HSP 1 Score: 63.1586 bits (152), Expect = 1.327e-12
Identity = 24/53 (45.28%), Postives = 33/53 (62.26%), Query Frame = 1

Query:   97 PECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            P C L +DQGPCR     ++++ +   C +F YGGC GN N F T EEC++ C
Sbjct: 1081 PRCELTLDQGPCREYNIRWYYDKQANACAQFWYGGCDGNRNRFDTEEECKKTC 1133

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:103022515])

HSP 1 Score: 62.3882 bits (150), Expect = 2.511e-12
Identity = 25/56 (44.64%), Postives = 34/56 (60.71%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            K  C LE + GPCRA+ P + F+ +  KC  F+YGGC GN N F + E C   C++
Sbjct:  312 KAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:103022515])

HSP 1 Score: 62.3882 bits (150), Expect = 2.514e-12
Identity = 25/56 (44.64%), Postives = 34/56 (60.71%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            K  C LE + GPCRA+ P + F+ +  KC  F+YGGC GN N F + E C   C++
Sbjct:  312 KAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:103022515])

HSP 1 Score: 62.003 bits (149), Expect = 2.845e-12
Identity = 25/56 (44.64%), Postives = 34/56 (60.71%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            K  C LE + GPCRA+ P + F+ +  KC  F+YGGC GN N F + E C   C++
Sbjct:  312 KAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: ENSAMXT00000051114.1 (pep primary_assembly:Astyanax_mexicanus-2.0:11:5183832:5196079:-1 gene:ENSAMXG00000033686.1 transcript:ENSAMXT00000051114.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.4622 bits (145), Expect = 2.848e-12
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQE 249
            CLL+ DQGPCRA    +F++T+  +C  F YGGC GN N F + EEC++
Sbjct:  124 CLLKNDQGPCRAYLLKWFYDTQQNECARFWYGGCKGNGNRFDSQEECED 172

HSP 2 Score: 45.8246 bits (107), Expect = 9.587e-7
Identity = 22/54 (40.74%), Postives = 27/54 (50.00%), Query Frame = 1

Query:   97 PECLLEMDQG-PCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             +C L MD G PC      ++++   G C  F YGGC GN N F T  EC   C
Sbjct:   19 AQCSLSMDSGTPCGQYVQRWYYDKAVGACSPFWYGGCSGNSNRFKTEFECINTC 72

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:ZFIN;Acc:ZDB-GENE-060503-38])

HSP 1 Score: 62.7734 bits (151), Expect = 1.660e-13
Identity = 28/59 (47.46%), Postives = 37/59 (62.71%), Query Frame = 1

Query:   82 IECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            +E ++  C L    G CRAAFP +FFN  T +CE F+YGGC  N+N F T +EC+  C 
Sbjct:   20 LEDQRVTCTLPAKPGDCRAAFPRYFFNRSTLRCESFIYGGCHSNENNFETMQECRAACS 78

HSP 2 Score: 47.3654 bits (111), Expect = 6.548e-8
Identity = 25/62 (40.32%), Postives = 32/62 (51.61%), Query Frame = 1

Query:   70 AIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            A  FI+     C  + + G CRA    +F+N   G C  FVYGGC GN+N F   E C  +C
Sbjct:   76 ACSFIKKIPKLCRPDAETGRCRAHITRYFYNMTLGMCMPFVYGGCGGNNNRFEDMESCVFSC 137

HSP 3 Score: 43.5134 bits (101), Expect = 1.394e-6
Identity = 20/52 (38.46%), Postives = 27/52 (51.92%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            ECL   D G C+  F  F++N +   C  F Y GC GN+N F + + C   C
Sbjct:  146 ECLSRHDTGNCQGNFRRFYYNIQKRSCLPFSYSGCGGNNNNFISAKTCLSTC 197

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005038.1 (pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 gene:ENSPMAG00000004579.1 transcript:ENSPMAT00000005038.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.4622 bits (145), Expect = 1.015e-12
Identity = 25/52 (48.08%), Postives = 32/52 (61.54%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             C++++D GPCRA  P  F+N  T +CE F YGGC GN N F +  EC   C
Sbjct:    2 SCMMDLDPGPCRAYLPRVFYNRYTQRCEPFHYGGCFGNGNNFESLAECNAKC 53

HSP 2 Score: 55.8398 bits (133), Expect = 5.557e-11
Identity = 24/51 (47.06%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            CL++ D G C A  P F +N +T  CE F YGGC GNDN F +   C   C
Sbjct:  167 CLMKADPGECTAVIPRFHYNPKTSNCESFTYGGCGGNDNNFSSERSCMSVC 217

HSP 3 Score: 54.6842 bits (130), Expect = 1.112e-10
Identity = 27/61 (44.26%), Postives = 35/61 (57.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK*I*PILLK 285
            C L+M+ G CRA    +FFN  +G CEEF YGGC GN N F     C ++C     P+ +K
Sbjct:   75 CRLDMEVGVCRALLRRYFFNMTSGSCEEFGYGGCQGNLNNFKDAASCYQHCVHRAVPLKIK 135

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005043.1 (pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 gene:ENSPMAG00000004579.1 transcript:ENSPMAT00000005043.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.4622 bits (145), Expect = 1.101e-12
Identity = 25/52 (48.08%), Postives = 32/52 (61.54%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
             C++++D GPCRA  P  F+N  T +CE F YGGC GN N F +  EC   C
Sbjct:    2 SCMMDLDPGPCRAYLPRVFYNRYTQRCEPFHYGGCFGNGNNFESLAECNAKC 53

HSP 2 Score: 55.4546 bits (132), Expect = 6.226e-11
Identity = 24/51 (47.06%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            CL++ D G C A  P F +N +T  CE F YGGC GNDN F +   C   C
Sbjct:  166 CLMKADPGECTAVIPRFHYNPKTSNCESFTYGGCGGNDNNFSSERSCMSVC 216

HSP 3 Score: 54.6842 bits (130), Expect = 1.497e-10
Identity = 27/61 (44.26%), Postives = 35/61 (57.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK*I*PILLK 285
            C L+M+ G CRA    +FFN  +G CEEF YGGC GN N F     C ++C     P+ +K
Sbjct:   74 CRLDMEVGVCRALLRRYFFNMTSGSCEEFGYGGCQGNLNNFKDAASCYQHCVHRAVPLKIK 134

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009465.1 (pep scaffold:Pmarinus_7.0:GL478507:22936:25713:-1 gene:ENSPMAG00000008558.1 transcript:ENSPMAT00000009465.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.8322 bits (120), Expect = 4.115e-9
Identity = 24/53 (45.28%), Postives = 31/53 (58.49%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            CLLE   GPCR +F  + ++ E+  C+EF YGGC GN N F    EC   C +
Sbjct:   72 CLLEEAVGPCRGSFTRWIYDAESSNCKEFTYGGCGGNFNNFLEETECMVTCGR 124

HSP 2 Score: 50.447 bits (119), Expect = 5.328e-9
Identity = 23/53 (43.40%), Postives = 30/53 (56.60%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            CLL    GPCR +F  + ++  T  C+EF YGGC GN N F    EC  +C +
Sbjct:    1 CLLNPTTGPCRGSFTRWTYDAATSTCKEFTYGGCRGNQNNFLEEAECLMDCGR 53

HSP 3 Score: 49.6766 bits (117), Expect = 1.006e-8
Identity = 26/64 (40.62%), Postives = 35/64 (54.69%), Query Frame = 1

Query:   64 IFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            +F +Q +      CLLE    PCR +F  + ++ E+G C+EF YGGC GN N F    EC   C
Sbjct:  159 LFHVQDV------CLLEAVTSPCRGSFTRWTYDAESGHCKEFTYGGCGGNFNNFLEETECVAMC 216

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30912])

HSP 1 Score: 51.2174 bits (121), Expect = 4.271e-9
Identity = 21/51 (41.18%), Postives = 32/51 (62.75%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C L + QGPC+     + +N    +C+ F+YGGC GN+N F + E C++NC
Sbjct:  374 CSLPVQQGPCKQWALRWAYNPLIKRCQSFIYGGCEGNENNFQSQELCEDNC 424

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO29819 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2J6])

HSP 1 Score: 66.2402 bits (160), Expect = 4.815e-16
Identity = 29/51 (56.86%), Postives = 36/51 (70.59%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C L    G CRAA P  FFN+++GKCE+F+YGGC GN N F T EEC++ C
Sbjct:   14 CTLPKKVGDCRAAMPRVFFNSQSGKCEDFIYGGCGGNANNFHTMEECKKAC 64

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO42139 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F4])

HSP 1 Score: 66.6254 bits (161), Expect = 3.011e-14
Identity = 26/53 (49.06%), Postives = 34/53 (64.15%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            C+LE   GPCR AFP ++++T    C EF+YGGC GN N F +  EC E C +
Sbjct:  743 CVLENATGPCRGAFPKWYYSTADNACHEFLYGGCGGNANKFDSKSECLEVCYR 795

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO41696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3T1])

HSP 1 Score: 57.3806 bits (137), Expect = 9.327e-13
Identity = 26/52 (50.00%), Postives = 34/52 (65.38%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            ECL     GPCRA F  +F+N  + KC++FVYGGC GN N F +  EC++ C
Sbjct:    1 ECLQPKLTGPCRAYFERWFYNQTSRKCKQFVYGGCQGNSNNFESKAECEKKC 52

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO26263 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3T1])

HSP 1 Score: 57.3806 bits (137), Expect = 9.327e-13
Identity = 26/52 (50.00%), Postives = 34/52 (65.38%), Query Frame = 1

Query:  100 ECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            ECL     GPCRA F  +F+N  + KC++FVYGGC GN N F +  EC++ C
Sbjct:    1 ECLQPKLTGPCRAYFERWFYNQTSRKCKQFVYGGCQGNSNNFESKAECEKKC 52

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO47795 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL41])

HSP 1 Score: 56.9954 bits (136), Expect = 1.682e-12
Identity = 21/52 (40.38%), Postives = 33/52 (63.46%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C L    GPC A  P +++N +  +C++FVYGGC GN N F ++  C+ +C+
Sbjct:    2 CQLPKLPGPCSAYVPRWYYNAKHRRCQKFVYGGCRGNANRFKSHRSCERSCK 53

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:NCBI gene;Acc:101174930])

HSP 1 Score: 65.0846 bits (157), Expect = 1.651e-13
Identity = 30/74 (40.54%), Postives = 42/74 (56.76%), Query Frame = 1

Query:   34 NFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
              +  F++F           K  CLL +D+GPCR     +F+NT T KCE F YGGC GN N F ++++CQ+ C
Sbjct:   61 GMLTLFALFSSLPGGLSLVPKGACLLRVDEGPCRGQIERYFYNTITQKCEVFYYGGCHGNANNFMSFQKCQKTC 134

HSP 2 Score: 52.7582 bits (125), Expect = 4.834e-9
Identity = 24/52 (46.15%), Postives = 29/52 (55.77%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            C    ++G CRA FP +FFN  T +CE F YGGC GN N F     C + C 
Sbjct:  144 CRFPKEEGHCRALFPSYFFNMSTMQCEPFSYGGCGGNSNRFRDLTSCMDFCS 195

HSP 3 Score: 51.2174 bits (121), Expect = 1.323e-8
Identity = 23/53 (43.40%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            CL  +D+G C A+   F++N  T  CEEF Y GC G+ N F + E C++ C K
Sbjct:  204 CLDPLDKGKCSASMRRFYYNKATKTCEEFAYSGCGGSSNNFVSRESCEDVCLK 256

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: ENSORLT00000018112.2 (tissue factor pathway inhibitor [Source:NCBI gene;Acc:101174546])

HSP 1 Score: 65.0846 bits (157), Expect = 2.092e-13
Identity = 28/51 (54.90%), Postives = 34/51 (66.67%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C ++ D GPCRA    +FFN  T +CEEF YGGC GN N F T +EC+E C
Sbjct:   40 CAMKADPGPCRAIKDRYFFNVSTARCEEFEYGGCSGNSNNFVTLQECEETC 90

HSP 2 Score: 56.9954 bits (136), Expect = 1.613e-10
Identity = 25/55 (45.45%), Postives = 32/55 (58.18%), Query Frame = 1

Query:   94 KPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCE 258
            K  C LE   GPCR     +FF+++T +C  F YGGC GN N F +  ECQ  C+
Sbjct:   96 KNPCHLEEAPGPCRGLLSRYFFDSKTRQCRRFFYGGCFGNANNFWSMAECQAKCQ 150

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:101168561])

HSP 1 Score: 63.1586 bits (152), Expect = 1.366e-12
Identity = 26/62 (41.94%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   76 QFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            + +E  K  C LE + GPCRA+ P + F+    KC  F+YGGC GN N F + E C   C++
Sbjct:  305 KIVEEVKAVCTLEAETGPCRASMPRWHFDLSQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 366

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:101168561])

HSP 1 Score: 63.1586 bits (152), Expect = 1.378e-12
Identity = 26/62 (41.94%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   76 QFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            + +E  K  C LE + GPCRA+ P + F+    KC  F+YGGC GN N F + E C   C++
Sbjct:  305 KIVEEVKAVCTLEAETGPCRASMPRWHFDLSQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 366

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: APP (amyloid-beta A4 protein [Source:NCBI gene;Acc:101162104])

HSP 1 Score: 62.7734 bits (151), Expect = 1.536e-12
Identity = 24/51 (47.06%), Postives = 32/51 (62.75%), Query Frame = 1

Query:  103 CLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENC 255
            C  + + GPCRA  P +FF+ E G+C +F+YGGC GN N F + E C   C
Sbjct:  330 CWADAETGPCRALLPRWFFDREEGRCVQFIYGGCGGNRNNFESEEYCMSVC 380

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000013909.1 (SMESG000013909.1)

HSP 1 Score: 157.532 bits (397), Expect = 8.795e-52
Identity = 77/77 (100.00%), Postives = 77/77 (100.00%), Query Frame = 1

Query:   31 MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK
Sbjct:    1 MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 77

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000013911.1 (SMESG000013911.1)

HSP 1 Score: 79.337 bits (194), Expect = 8.078e-21
Identity = 39/76 (51.32%), Postives = 50/76 (65.79%), Query Frame = 1

Query:   34 NFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            +F+I  + F+ F +++ E R   CLL   +G CR  F  FFFN E+GKCEE VYGGC GN+N F T EEC E C+K
Sbjct:    3 SFVIILTSFIFF-VKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 77

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000013910.1 (SMESG000013910.1)

HSP 1 Score: 78.1814 bits (191), Expect = 2.229e-20
Identity = 37/71 (52.11%), Postives = 47/71 (66.20%), Query Frame = 1

Query:   49 FSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            FS+    AI   +C++PEC L  + G CR  FP +FFN ETGKCE+F+YGGC GN N F T  EC+  CE+
Sbjct:    2 FSVIFAVAIHLGDCKEPECSLPKEVGLCRGYFPRYFFNEETGKCEKFIYGGCQGNKNNFYTPIECRARCEQ 72

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000038055.1 (SMESG000038055.1)

HSP 1 Score: 78.1814 bits (191), Expect = 2.774e-20
Identity = 38/77 (49.35%), Postives = 48/77 (62.34%), Query Frame = 1

Query:   31 MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            MN +I  S   + A+Q IE + PEC L ++ G CRA F  + F+ + GKC  FVYGGC  NDN F T  EC+E CEK
Sbjct:    1 MNSLIIISCLFVTALQLIEGKAPECNLSLETGLCRAYFVRYGFDVKLGKCRTFVYGGCPVNDNNFHTRAECEERCEK 77

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000038052.1 (SMESG000038052.1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.085e-18
Identity = 35/77 (45.45%), Postives = 46/77 (59.74%), Query Frame = 1

Query:   31 MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 261
            MN ++ FS   +  +Q  E + PEC L ++ G C A F  + F+ + GKC  FVYGGC  NDN F T  EC+E CEK
Sbjct:    1 MNSLVIFSCIFVAVLQLTESKSPECNLPLETGLCEAYFVRYGFDVKLGKCRTFVYGGCHVNDNNFHTRAECEERCEK 77

The following BLAST results are available for this feature:

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
BLAST of Tissue factor pathway inhibitor vs. TrEMBL
BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
BLAST of Tissue factor pathway inhibitor vs. Ensembl Yeast
BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TFPI	4.117e-13	50.94	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
TFPI	4.117e-13	50.94	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
TFPI	5.682e-13	52.94	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
WFIKKN2	1.836e-12	50.98	WAP, follistatin/kazal, immunoglobulin, kunitz and...	[more]
WFIKKN2	2.147e-12	50.98	WAP, follistatin/kazal, immunoglobulin, kunitz and...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mig-6	1.705e-12	49.12	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	1.705e-12	49.12	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	8.562e-12	49.09	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	8.562e-12	49.09	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	8.562e-12	49.09	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG10031	5.698e-14	47.17	gene:FBgn0031563 transcript:FBtr0077544	[more]
CG17380	4.678e-11	39.44	gene:FBgn0039077 transcript:FBtr0299867	[more]
CG13748	8.095e-11	44.23	gene:FBgn0033355 transcript:FBtr0088656	[more]
IM33	8.150e-10	34.15	gene:FBgn0031561 transcript:FBtr0077546	[more]
IM33	8.150e-10	34.15	gene:FBgn0031561 transcript:FBtr0345610	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
spint2	1.225e-12	50.00	serine peptidase inhibitor, Kunitz type, 2 [Source...	[more]
spint2	1.237e-12	50.00	serine peptidase inhibitor, Kunitz type, 2 [Source...	[more]
wu:fb59d01	2.638e-12	50.98	wu:fb59d01 [Source:ZFIN;Acc:ZDB-GENE-030131-1098]	[more]
tfpia	4.134e-12	50.98	tissue factor pathway inhibitor a [Source:ZFIN;Acc...	[more]
tfpia	4.151e-12	50.98	tissue factor pathway inhibitor a [Source:ZFIN;Acc...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tfpi2	1.306e-11	47.17	tissue factor pathway inhibitor 2 [Source:NCBI gen...	[more]
rlbp1	6.853e-11	43.86	retinaldehyde binding protein 1 [Source:Xenbase;Ac...	[more]
rlbp1	2.460e-10	45.45	retinaldehyde binding protein 1 [Source:Xenbase;Ac...	[more]
ric8a	2.805e-10	41.51	RIC8 guanine nucleotide exchange factor A [Source:...	[more]
rlbp1	3.003e-10	45.45	retinaldehyde binding protein 1 [Source:Xenbase;Ac...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tfpi	1.319e-13	52.94	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]
Tfpi	1.319e-13	52.94	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]
Tfpi	1.319e-13	52.94	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]
Spint3	1.771e-13	50.94	serine peptidase inhibitor, Kunitz type, 3 [Source...	[more]
Tfpi	1.774e-13	52.94	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9TWG0\|VKT1_ANESU	2.849e-15	51.92	KappaPI-actitoxin-Avd3b OS=Anemonia sulcata OX=610...	[more]
sp\|P0DMJ2\|VKT3C_ACTEQ	3.421e-15	56.86	PI-actitoxin-Aeq3c OS=Actinia equina OX=6106 PE=1 ...	[more]
sp\|P0DN06\|VKT1A_ANEVI	4.416e-15	51.92	U-actitoxin-Avd3f OS=Anemonia viridis OX=51769 PE=...	[more]
sp\|P81547\|VKT1_ANTAF	6.596e-15	52.83	PI-actitoxin-Axm2a OS=Anthopleura aff. xanthogramm...	[more]
sp\|P0DN19\|VKTF_ANEVI	1.028e-14	53.85	U-actitoxin-Avd3r (Fragment) OS=Anemonia viridis O...	[more]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C3ZCN3	2.072e-16	62.26	BPTI/Kunitz inhibitor domain-containing protein (F...	[more]
I1ZII0	1.044e-15	43.84	Serine protease inhibitor-1 (Fragment) OS=Schmidte...	[more]
A0A3Q3KHW0	1.141e-15	55.93	BPTI/Kunitz inhibitor domain-containing protein OS...	[more]
A0A3Q1AGU6	1.181e-15	41.18	Uncharacterized protein OS=Amphiprion ocellaris OX...	[more]
A0A3Q1AGY5	1.374e-15	41.18	Uncharacterized protein OS=Amphiprion ocellaris OX...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
col28a2b	1.327e-12	45.28	collagen, type XXVIII, alpha 2b [Source:ZFIN;Acc:Z...	[more]
aplp2	2.511e-12	44.64	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	2.514e-12	44.64	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	2.845e-12	44.64	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
ENSAMXT00000051114.1	2.848e-12	51.02	pep primary_assembly:Astyanax_mexicanus-2.0:11:518...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tfpi2	1.660e-13	47.46	tissue factor pathway inhibitor 2 [Source:ZFIN;Acc...	[more]
ENSPMAT00000005038.1	1.015e-12	48.08	pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 g...	[more]
ENSPMAT00000005043.1	1.101e-12	48.08	pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 g...	[more]
ENSPMAT00000009465.1	4.115e-9	45.28	pep scaffold:Pmarinus_7.0:GL478507:22936:25713:-1 ...	[more]
WFIKKN1	4.271e-9	41.18	WAP, follistatin/kazal, immunoglobulin, kunitz and...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO29819	4.815e-16	56.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42139	3.011e-14	49.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41696	9.327e-13	50.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO26263	9.327e-13	50.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47795	1.682e-12	40.38	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tfpi2	1.651e-13	40.54	tissue factor pathway inhibitor 2 [Source:NCBI gen...	[more]
ENSORLT00000018112.2	2.092e-13	54.90	tissue factor pathway inhibitor [Source:NCBI gene;...	[more]
aplp2	1.366e-12	41.94	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	1.378e-12	41.94	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
APP	1.536e-12	47.06	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000013909.1	8.795e-52	100.00	SMESG000013909.1	[more]
SMESG000013911.1	8.078e-21	51.32	SMESG000013911.1	[more]
SMESG000013910.1	2.229e-20	52.11	SMESG000013910.1	[more]
SMESG000038055.1	2.774e-20	49.35	SMESG000038055.1	[more]
SMESG000038052.1	1.085e-18	45.45	SMESG000038052.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence

transcript sequence

>SMED30034647 ID=SMED30034647|Name=Tissue factor pathway inhibitor|organism=Schmidtea mediterranea sexual|type=transcript|length=324bp
AAAACTTTTTCGAATAAAAAAATTACAAAAATGAATTTCATCATTACATT
TTCCATATTTGTTATATTCGCTATTCAATTTATTGAATGCCGAAAACCAG
AATGTCTTCTTGAAATGGATCAAGGACCATGTAGGGCTGCTTTCCCCATG
TTCTTTTTTAACACAGAAACAGGAAAATGTGAAGAATTCGTTTATGGAGG
TTGTTTGGGAAATGATAATTTGTTTGGAACTTATGAGGAATGCCAAGAAA
ACTGTGAGAAATGAATATGACCAATATTGTTAAAAATGTTATTTTTAATA
AATTATTAATTGTTAAAAAAAAAA

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region

Vocabulary: **biological process**
Term	Definition
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000419	prepharyngeal region
PLANA:0000421	tail

Vocabulary: **INTERPRO**
Term	Definition
IPR036880	Kunitz_BPTI_sf
IPR002223	Kunitz_BPTI
IPR020901	Prtase_inh_Kunz-CS

Vocabulary: **molecular function**
Term	Definition
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PRINTS	PR00759	BASICPTASE	coord: 32..46 score: 37.54 coord: 60..70 score: 63.83 coord: 70..85 score: 45.66
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	SMART	SM00131	KU_2	coord: 33..86 e-value: 1.2E-20 score: 84.6
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PFAM	PF00014	Kunitz_BPTI	coord: 35..86 e-value: 6.9E-18 score: 64.6
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PROSITE	PS50279	BPTI_KUNITZ_2	coord: 35..85 score: 15.029
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	CDD	cd00109	KU	coord: 35..85 e-value: 2.49625E-19 score: 71.8974
IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	GENE3D	G3DSA:4.10.410.10		coord: 31..87 e-value: 1.6E-21 score: 77.9
IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	SUPERFAMILY	SSF57362	BPTI-like	coord: 29..86
None	No IPR available	PANTHER	PTHR10083	KUNITZ-TYPE PROTEASE INHIBITOR-RELATED	coord: 32..85
None	No IPR available	TMHMM	TMhelix		coord: 13..30
IPR020901	Proteinase inhibitor I2, Kunitz, conserved site	PROSITE	PS00280	BPTI_KUNITZ_1	coord: 63..81

Main menu

Tissue factor pathway inhibitor

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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