Neuropilin (NRP) and tolloid (TLL)-like 2b

Overview
NameNeuropilin (NRP) and tolloid (TLL)-like 2b
Smed IDSMED30034627
Length (bp)1853
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Neuropilin (NRP) and tolloid (TLL)-like 2b (SMED30034627) t-SNE clustered cells

Violin plots show distribution of expression levels for Neuropilin (NRP) and tolloid (TLL)-like 2b (SMED30034627) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Neuropilin (NRP) and tolloid (TLL)-like 2b (SMED30034627) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Neuropilin (NRP) and tolloid (TLL)-like 2b (SMED30034627) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034627

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
muscle cellSMED30034627SMESG000028496.1 dd_Smed_v4_10760_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30034627SMESG000028496.1 dd_Smed_v6_10760_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
enteric muscle cellSMED30034627SMESG000028496.1 dd_Smed_v4_10760_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Human
Match: NETO2 (neuropilin and tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:14644])

HSP 1 Score: 95.1301 bits (235), Expect = 6.392e-20
Identity = 74/263 (28.14%), Postives = 126/263 (47.91%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T       P   C  ++   +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F    ++    V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVK-SPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFEL---SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSSIENLKAKFC---STVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 328
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Human
Match: NETO2 (neuropilin and tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:14644])

HSP 1 Score: 93.5893 bits (231), Expect = 1.664e-19
Identity = 78/284 (27.46%), Postives = 122/284 (42.96%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIE-IYDRITGP--LVVDRYKNYFLINENS---NFEKVY----------------------LKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F                  IP                   +F  + +C F++S   G++  V  SQ+ +   T  GQ ++ I+     P   +  R+ +Y + + N    NF  VY                      LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVK-SPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSF------------------IP-----------------DPDFTYLGDCQFELS---GADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 321
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Human
Match: NETO1 (neuropilin and tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:13823])

HSP 1 Score: 90.1225 bits (222), Expect = 2.451e-18
Identity = 80/289 (27.68%), Postives = 128/289 (44.29%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE-ICEGQFVNKIAGITSLTATTG 1152
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I +FCG + +   I+S+  +LW++F++D    + GF   Y F+   +       +P   C  +M         +      K   +       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F    ++    V L+    VIR+          FQ++ T+       C    F C  + CI+ TLVCN L+NC    DE  C+ +   K + +  LT T+G
Sbjct:   71 IIEA-APRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKAKFC---STVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSF--QEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK--RKTSLLDQLTNTSG 343
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Human
Match: NETO1 (neuropilin and tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:13823])

HSP 1 Score: 90.1225 bits (222), Expect = 2.451e-18
Identity = 80/289 (27.68%), Postives = 128/289 (44.29%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE-ICEGQFVNKIAGITSLTATTG 1152
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I +FCG + +   I+S+  +LW++F++D    + GF   Y F+   +       +P   C  +M         +      K   +       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F    ++    V L+    VIR+          FQ++ T+       C    F C  + CI+ TLVCN L+NC    DE  C+ +   K + +  LT T+G
Sbjct:   71 IIEA-APRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKAKFC---STVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSF--QEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK--RKTSLLDQLTNTSG 343
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Human
Match: NETO1 (neuropilin and tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:13823])

HSP 1 Score: 72.0182 bits (175), Expect = 3.558e-14
Identity = 34/87 (39.08%), Postives = 54/87 (62.07%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFS 567
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I +FCG + +   I+S+  +LW++F++D    + GF   Y F+
Sbjct:   70 IIEA-APRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELESMGFSARYNFT 154
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Celegans
Match: neto-1 (NETO (NEuropilin and TOlloid-like) homolog [Source:UniProtKB/TrEMBL;Acc:O61849])

HSP 1 Score: 91.6633 bits (226), Expect = 9.041e-20
Identity = 73/268 (27.24%), Postives = 113/268 (42.16%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVD-------CFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQ-FIEIYDRITGPLVVDRY----KNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEE-FQCKGSFCISKTLVCNNLRNCPSADDE 1089
            P   + ++F   F IE + D       C NDF++  DG +GFS LI++FCG  + K  I++ S +LW+RF SD      GF   Y    SK        C  + Y+   +  +   +L+    L  N  G  +C++ ++V     I   + +   T+       F+E+Y   T    + R+     N      N  F + YL   R++       + S  T           +KNC+ E  F C    C+ K+L CN   NCP   DE
Sbjct:   63 PQHDVVVKFHHVFHIESTYDKIDAGEECPNDFIEFRDGRYGFSPLIARFCGDRMPKREIRAVSGFLWIRFRSDSMLEYQGFSAEYAIVPSKTGRFNNHECLLE-YLNGLDGFIRTKDLIS--NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKPLRRFCGLTANDVFSPSNEMFVRFYLSDVRSLNTTSISALFSSYT----------RLKNCTQEGLFACGDENCVPKSLACNGRPNCPYGRDE 317
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Fly
Match: Neto (gene:FBgn0265416 transcript:FBtr0339703)

HSP 1 Score: 114.39 bits (285), Expect = 4.204e-26
Identity = 85/272 (31.25%), Postives = 133/272 (48.90%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFV-----ALSQLNKTSMTGLGQFIEIY-DRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVM--TFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCP-SADDEIC 1095
            +I AP     I L+FR +F IE    C  DFL+I DG +GFS LI KFCGT+   E I S   YLWL F+SD+T   +GF  +Y++ +   +   T +            +       + ++  N  K   +CI+ I VK+   IF+      LS+ N         F++I+ ++   PL   R KN+      S  E +  + +  ++ ++F   ++ +  TF ++ TA       C+ +E+ C+ + CISK L CNNL NC    D+E C
Sbjct:  170 VITAPK-GQIIRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPE-ITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTIDKGGFEGFINSTDVPAEIWEQVNRNKIALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQT----NFLDIFPEQTVMPL---RVKNFC----GSAGESITAESN--ILHLRFYADQTAINSTFGILFTAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 426
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Fly
Match: Neto (gene:FBgn0265416 transcript:FBtr0339702)

HSP 1 Score: 113.235 bits (282), Expect = 8.263e-26
Identity = 85/272 (31.25%), Postives = 133/272 (48.90%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFV-----ALSQLNKTSMTGLGQFIEIY-DRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVM--TFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCP-SADDEIC 1095
            +I AP     I L+FR +F IE    C  DFL+I DG +GFS LI KFCGT+   E I S   YLWL F+SD+T   +GF  +Y++ +   +   T +            +       + ++  N  K   +CI+ I VK+   IF+      LS+ N         F++I+ ++   PL   R KN+      S  E +  + +  ++ ++F   ++ +  TF ++ TA       C+ +E+ C+ + CISK L CNNL NC    D+E C
Sbjct:  170 VITAPK-GQIIRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPE-ITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTIDKGGFEGFINSTDVPAEIWEQVNRNKIALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTN----FLDIFPEQTVMPL---RVKNFC----GSAGESITAESN--ILHLRFYADQTAINSTFGILFTAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 426
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Fly
Match: Cubn (gene:FBgn0052702 transcript:FBtr0273437)

HSP 1 Score: 57.3806 bits (137), Expect = 4.696e-8
Identity = 28/78 (35.90%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  328 SMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISK-ETIQSTSNYLWLRFYSDKTETNSGFKVIY 558
            S+ +N+ F  +F++EDS +C  D+LQINDG    + +I ++CG  +     I S+ N L+L F SD +    GF + +
Sbjct:  544 SLVVNVTF-NSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTW 620

HSP 2 Score: 55.8398 bits (133), Expect = 1.239e-7
Identity = 25/77 (32.47%), Postives = 51/77 (66.23%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKV 552
            +P   I++EF   F ++D+  C +D++++ DG   F+++I +FCG +    T+++T + L++RF +D   T++GF+V
Sbjct: 3285 NPDQQISVEF-SNFHVQDTDGCRSDYVELRDGGGTFADIIGRFCG-QNQPPTLRTTRHTLYMRFVTDNKVTDTGFQV 3359

HSP 3 Score: 52.373 bits (124), Expect = 1.512e-6
Identity = 40/149 (26.85%), Postives = 71/149 (47.65%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSV----DCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNI 741
            I++AP P   I L F+  F++ D+     +C  +F+ INDG       I ++CG     +TI ST N + +R+++D +E + GF      +           C    + P       + +LL  ++     K ++EC++ I ++KGS I
Sbjct: 2295 IVEAP-PEHRIMLHFQGAFDMLDATGEPEECQREFVLINDGSTELRPEIGRYCGNR-KPDTIYSTGNQMRIRYFTDVSEPHMGFNASLSVAR----------CGGSFHSPEGVIASPSRDLLLIHE---EGKQLQECVYTIELEKGSTI 2428
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Fly
Match: CG42255 (gene:FBgn0259140 transcript:FBtr0332131)

HSP 1 Score: 57.3806 bits (137), Expect = 4.847e-8
Identity = 30/78 (38.46%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  331 MTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEI--SKETIQSTSNYLWLRFYSDKTETNSGFKVIY 558
            M +NL F + F++EDS DC  DFLQ++DG    S LI +FCG+ +  +  ++ +T   ++  F SD      GF VI+
Sbjct:  541 MVLNLTFTQ-FQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTNGSVITTQEQVFFWFRSDNQTQGKGFHVIW 617
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Fly
Match: tld (gene:FBgn0003719 transcript:FBtr0084691)

HSP 1 Score: 51.6026 bits (122), Expect = 2.386e-6
Identity = 41/110 (37.27%), Postives = 65/110 (59.09%), Query Frame = 1 
Query:  223 SDLSLDREYSLQSXXXXXXXXXXXXXXXIIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKV 552
             DL L ++ S+ SPNYP +Y  + +CV+ I AP  +  + L+F ++FE+E    C  DF++I DG    S LI +FCG ++    I++ SN +++RF SD +    GF  
Sbjct:  480 GDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPD-NHQVALKF-QSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPP-NIKTRSNQMYIRFVSDSSVQKLGFSA 586
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Zebrafish
Match: neto1 (neuropilin (NRP) and tolloid (TLL)-like 1 [Source:ZFIN;Acc:ZDB-GENE-070912-592])

HSP 1 Score: 101.293 bits (251), Expect = 4.623e-22
Identity = 78/267 (29.21%), Postives = 120/267 (44.94%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+A +P   I+L F   + IE S +C  D +++ DGPF FS +I ++CG ++S   ++S+  YLW++F +D     +GF   Y F+   E        P  IC   M  P      +  +   K   T       +C + I    GS IF+  L    + S      F+ +YD   G   V+  KN F    ++    V L     VIR+          F+++ T    +   C S+ F C  + CI+ TLVCN ++NC    DE
Sbjct:   74 IIEA-APRQCIDLYFDYKYAIEPSWECKFDHIEVRDGPFSFSPIIGRYCG-QVSPNYVRSSGRYLWIKFVADSELEATGFSARYNFTQDPEFKDLGAQPPLPICEFDMSGPEGIVESVMVSKEGKALQTEAV----DCRWFIRAPPGSKIFLRFLDYEMQNSNECKRNFVAVYD---GSSSVEHLKNKFC---STVANDVMLLNSLGVIRMWADETSRRSRFRILFTTF--HEPPCGSDTFFCHSNMCINHTLVCNGIQNCVYPWDE 326
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Zebrafish
Match: neto1 (neuropilin (NRP) and tolloid (TLL)-like 1 [Source:ZFIN;Acc:ZDB-GENE-070912-592])

HSP 1 Score: 99.7525 bits (247), Expect = 7.651e-22
Identity = 75/262 (28.63%), Postives = 116/262 (44.27%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I+L F   + IE S +C  D +++ DGPF FS +I ++CG ++S   ++S+  YLW++F +D     +GF   Y F+   E        P  IC   M  P      +  +   K   T       +C + I    GS IF+  L    + S      F+ +YD   G   V+  KN F    ++    V L     VIR+          F+++ T    +   C S+ F C  + CI+ TLVCN ++NC    DE
Sbjct:   13 APRQCIDLYFDYKYAIEPSWECKFDHIEVRDGPFSFSPIIGRYCG-QVSPNYVRSSGRYLWIKFVADSELEATGFSARYNFTQDPEFKDLGAQPPLPICEFDMSGPEGIVESVMVSKEGKALQTEAV----DCRWFIRAPPGSKIFLRFLDYEMQNSNECKRNFVAVYD---GSSSVEHLKNKFC---STVANDVMLLNSLGVIRMWADETSRRSRFRILFTTF--HEPPCGSDTFFCHSNMCINHTLVCNGIQNCVYPWDE 261
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Zebrafish
Match: neto1l (neuropilin (NRP) and tolloid (TLL)-like 1, like [Source:ZFIN;Acc:ZDB-GENE-091207-1])

HSP 1 Score: 93.9745 bits (232), Expect = 1.040e-19
Identity = 74/271 (27.31%), Postives = 126/271 (46.49%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIE----ECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+AP P   I+L F E + IE S +C  D +++ DGPFGFS +I ++CG + +   I+S+  YLW++F +D      GF   Y F++  +       +P   C  +M  P          +++  Q+T + + ++    +C + I     S I++  L    + S      ++ +YD   G   V+  +N F    ++    V L     VIR+          F+++ T        C ++ F C  + CI+ TLVCN ++NC    DE
Sbjct:   70 IIEAP-PRQCIDLFFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRYCGQQ-NPPYIRSSGRYLWIKFVADGELEAMGFSASYNFTSDPDFKDIGVPKPLPFCEFEMGGP--------EGIIESQQITKDGRALQTEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNYVAVYD---GSSSVEDLRNKFC---STVANDVMLVSALGVIRMWADEGSRKSRFRILFTTF--QEPPCEADTFFCHSNMCINNTLVCNGIQNCVYPWDE 322
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Zebrafish
Match: neto1l (neuropilin (NRP) and tolloid (TLL)-like 1, like [Source:ZFIN;Acc:ZDB-GENE-091207-1])

HSP 1 Score: 93.9745 bits (232), Expect = 1.134e-19
Identity = 74/271 (27.31%), Postives = 126/271 (46.49%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIE----ECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+AP P   I+L F E + IE S +C  D +++ DGPFGFS +I ++CG + +   I+S+  YLW++F +D      GF   Y F++  +       +P   C  +M  P          +++  Q+T + + ++    +C + I     S I++  L    + S      ++ +YD   G   V+  +N F    ++    V L     VIR+          F+++ T        C ++ F C  + CI+ TLVCN ++NC    DE
Sbjct:   74 IIEAP-PRQCIDLFFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRYCGQQ-NPPYIRSSGRYLWIKFVADGELEAMGFSASYNFTSDPDFKDIGVPKPLPFCEFEMGGP--------EGIIESQQITKDGRALQTEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNYVAVYD---GSSSVEDLRNKFC---STVANDVMLVSALGVIRMWADEGSRKSRFRILFTTF--QEPPCEADTFFCHSNMCINNTLVCNGIQNCVYPWDE 326
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Zebrafish
Match: neto2b (neuropilin (NRP) and tolloid (TLL)-like 2b [Source:ZFIN;Acc:ZDB-GENE-060503-638])

HSP 1 Score: 92.4337 bits (228), Expect = 2.717e-19
Identity = 76/263 (28.90%), Postives = 124/263 (47.15%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT-------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLN-KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            P   I L F +T+ IE S +C  D ++I DGPFGFS LI +FCG + S   + ST  ++W++F SD+     GF+V Y F    +          P   C  +  I  S+ V+ +S + ++ ++ N      +CI+ I     S I++   +   + S      F+ +YD   G   ++  K  F    ++    V L     V+R+       +  F+++ T+ V     CSS  F C  + CI+ +LVCN ++NC    DE
Sbjct:   68 PRQRIQLAFDKTYYIEPSFECRFDHIEIRDGPFGFSPLIDRFCGPK-SPGVVTSTGRFMWIKFTSDEELEGLGFRVKYTFIADPDFHLHVGGLLNPIPDC--QFEISGSDGVIHSSQVEEEDKIKNG--DALDCIWTIRAPPQSKIYLRFLEYQMEHSNECKKNFVAVYD---GSSAIENLKAKFC---STVANDVMLDTGVGVVRMWADESSRLSRFRMLFTSFVD--PPCSSSTFFCHSNMCINNSLVCNGVQNCVYPWDE 317
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Xenopus
Match: NETO1 (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:100492295])

HSP 1 Score: 94.3597 bits (233), Expect = 9.433e-20
Identity = 73/267 (27.34%), Postives = 118/267 (44.19%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT-----QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I ++CG + S   I+S+  +LW++F++D    + GF   Y F+   +       +P  +C  +M  P      +      K           +C + I     S I++  L    + S      F+ +YD   G   V+  +  F    ++    V L     VIR+          FQ++ T+       C +  F C  + CI+ TLVCN ++NC    DE
Sbjct:   53 IIEA-APRQCIELHFDENYSIESSWECKFDHIEVRDGPFGFSPIIGRYCGQQ-SPPFIKSSGRFLWIKFFADGELQSLGFSAQYNFTPDPDFKDLGILKPLPVCEFEMGGPEGIIESMQIVKEGKASANEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLRAKFC---STVANDVMLSTGLGVIRMWADEGSRTSRFQMLFTSF--QEPPCEANSFFCHSNMCINNTLVCNGIQNCVYPWDE 305
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Xenopus
Match: NETO1 (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:100492295])

HSP 1 Score: 94.3597 bits (233), Expect = 9.620e-20
Identity = 73/267 (27.34%), Postives = 118/267 (44.19%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT-----QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I ++CG + S   I+S+  +LW++F++D    + GF   Y F+   +       +P  +C  +M  P      +      K           +C + I     S I++  L    + S      F+ +YD   G   V+  +  F    ++    V L     VIR+          FQ++ T+       C +  F C  + CI+ TLVCN ++NC    DE
Sbjct:   71 IIEA-APRQCIELHFDENYSIESSWECKFDHIEVRDGPFGFSPIIGRYCGQQ-SPPFIKSSGRFLWIKFFADGELQSLGFSAQYNFTPDPDFKDLGILKPLPVCEFEMGGPEGIIESMQIVKEGKASANEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLRAKFC---STVANDVMLSTGLGVIRMWADEGSRTSRFQMLFTSF--QEPPCEANSFFCHSNMCINNTLVCNGIQNCVYPWDE 323
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Xenopus
Match: neto2 (neuropilin and tolloid like 2 [Source:NCBI gene;Acc:780374])

HSP 1 Score: 91.2781 bits (225), Expect = 8.644e-19
Identity = 69/263 (26.24%), Postives = 116/263 (44.11%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + +       P   C  ++   +           +K +         +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F     ++   V L+    V+R+       +  F+++ T+ V     C    F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDEPYHIEPSFECRFDHLEVRDGPFGFSPLIDRYCGLK-SPTPIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFSYLGGILSPIPDCQFELSGADGIIRSSQVEQEEKLKTGQAL----DCIWTIKATPKAKIYLRFLDYHMEHSNECKRNFVAVYD---GSSSIENLKAKFCSTVAND---VMLQTGIGVVRMWADEGSRLSRFRMLFTSFVE--PPCVGSTFFCHSNMCINNSLVCNGIQNCAYPWDE 328
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Xenopus
Match: neto2 (neuropilin and tolloid like 2 [Source:NCBI gene;Acc:780374])

HSP 1 Score: 89.3521 bits (220), Expect = 3.983e-18
Identity = 73/282 (25.89%), Postives = 118/282 (41.84%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIE-IYDRITGPLVVDRYKNYFLINENS---NFEKVY----------------------LKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F                  IP+ +             L      I +C F++S   G++  +  SQ+ +      GQ ++ I+     P      ++Y + + N    NF  VY                      L+    V+R+       +  F+++ T+ V     C    F C  + CI+ +LVCN ++NC    DE
Sbjct:   60 APRQRIELTFDEPYHIEPSFECRFDHLEVRDGPFGFSPLIDRYCGLK-SPTPIRSTGRFMWIKFSSDEELEGLGFRAKYSF------------------IPDPDFSY----------LGGILSPIPDCQFELS---GADGIIRSSQVEQEEKLKTGQALDCIWTIKATPKAKVCNRDYHMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLQTGIGVVRMWADEGSRLSRFRMLFTSFVE--PPCVGSTFFCHSNMCINNSLVCNGIQNCAYPWDE 307
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Xenopus
Match: neto2 (neuropilin and tolloid like 2 [Source:NCBI gene;Acc:780374])

HSP 1 Score: 88.9669 bits (219), Expect = 4.989e-18
Identity = 73/282 (25.89%), Postives = 118/282 (41.84%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIE-IYDRITGPLVVDRYKNYFLINENS---NFEKVY----------------------LKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F                  IP+ +             L      I +C F++S   G++  +  SQ+ +      GQ ++ I+     P      ++Y + + N    NF  VY                      L+    V+R+       +  F+++ T+ V     C    F C  + CI+ +LVCN ++NC    DE
Sbjct:   78 APRQRIELTFDEPYHIEPSFECRFDHLEVRDGPFGFSPLIDRYCGLK-SPTPIRSTGRFMWIKFSSDEELEGLGFRAKYSF------------------IPDPDFSY----------LGGILSPIPDCQFELS---GADGIIRSSQVEQEEKLKTGQALDCIWTIKATPKAKVCNRDYHMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLQTGIGVVRMWADEGSRLSRFRMLFTSFVE--PPCVGSTFFCHSNMCINNSLVCNGIQNCAYPWDE 325
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Mouse
Match: Neto2 (neuropilin (NRP) and tolloid (TLL)-like 2 [Source:MGI Symbol;Acc:MGI:1921763])

HSP 1 Score: 96.6709 bits (239), Expect = 1.479e-20
Identity = 75/263 (28.52%), Postives = 126/263 (47.91%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L+I DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T       P   C  ++   +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F     ++   V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDERYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGMK-SPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFEL---SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSAIENLKAKFCSTVAND---VMLKTGVGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 328
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Mouse
Match: Neto2 (neuropilin (NRP) and tolloid (TLL)-like 2 [Source:MGI Symbol;Acc:MGI:1921763])

HSP 1 Score: 95.1301 bits (235), Expect = 4.403e-20
Identity = 73/257 (28.40%), Postives = 124/257 (48.25%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L+I DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T      ++     +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F     ++   V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDERYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGMK-SPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGDCQFEL----SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSAIENLKAKFCSTVAND---VMLKTGVGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 321
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Mouse
Match: Neto2 (neuropilin (NRP) and tolloid (TLL)-like 2 [Source:MGI Symbol;Acc:MGI:1921763])

HSP 1 Score: 94.7449 bits (234), Expect = 5.671e-20
Identity = 73/257 (28.40%), Postives = 124/257 (48.25%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L+I DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T      ++     +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F    ++    V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:  114 APRQRIELTFDERYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGMK-SPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGDCQFEL----SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSAIENLKAKFC---STVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 356
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Mouse
Match: Neto1 (neuropilin (NRP) and tolloid (TLL)-like 1 [Source:MGI Symbol;Acc:MGI:2180216])

HSP 1 Score: 94.7449 bits (234), Expect = 6.660e-20
Identity = 81/289 (28.03%), Postives = 129/289 (44.64%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE-ICEGQFVNKIAGITSLTATTG 1152
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I +FCG + +   I+S+  +LW++F++D    + GF   Y F+   +       +P   C  +M  P      +      K   +       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F    ++    V L+    VIR+          FQ++ T+       C    F C  + CI+ TLVCN L+NC    DE  C+ +   K + +  LT T+G
Sbjct:   71 IIEA-APRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGVLKPLPACEFEMGGPEGIVESIQILKEGKASASEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKAKFC---STVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSF--QEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK--RKTSLLDQLTNTSG 343
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Mouse
Match: Cubn (cubilin (intrinsic factor-cobalamin receptor) [Source:MGI Symbol;Acc:MGI:1931256])

HSP 1 Score: 60.8474 bits (146), Expect = 6.028e-9
Identity = 47/165 (28.48%), Postives = 71/165 (43.03%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQ-FIEIYDR 813
            SP   I   F  T  +E   DC  D+L+I DGPF    ++ KFC T +S   +Q+T     + F+SD   ++ GF + Y        T P+ +     Y      +LL         LT  F    +C++ IS  +G  I +  + +   S  G    FIE+ D 
Sbjct:  623 SPGSLITFTF-GTLSLESHNDCSKDYLEIRDGPFHHDPILGKFC-TSLSTPPLQTTGPAARIHFHSDSETSDKGFHITYL-------TTPSDLYCGGNYTDTEGELLLP-------PLTGPFSHSRQCVYLISQPQGEQIVINFTHVELESQRGCSHTFIEVGDH 771

HSP 2 Score: 56.225 bits (134), Expect = 1.250e-7
Identity = 33/87 (37.93%), Postives = 55/87 (63.22%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFS 567
            I++AP  +  I+L F   F++EDS  C NDFL++ +G    S L+ K+C + +    I S SN L+L F+SD ++T+ G+++I+  S
Sbjct: 3424 ILRAPQ-NHRISL-FFYWFQLEDSRQCMNDFLEVRNGSSSSSPLLGKYC-SNLLPNPIFSQSNELYLHFHSDDSDTHHGYEIIWASS 3507

HSP 3 Score: 51.6026 bits (122), Expect = 3.541e-6
Identity = 40/180 (22.22%), Postives = 78/180 (43.33%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQ-FIEIYDRITGPLVVDRY 843
            I++APS   +I L+F + F IE++ +C   +L++ DG    + ++SK CG  + +  + S+   ++L+F+++      GFK  Y   +            + +  P             +    N F     C + I    G  + +     N  S  G  + F+EI++  T  +++ RY
Sbjct: 2250 ILEAPS-GRSIQLQFEDQFNIEETPNCSASYLELRDGANSNAPVLSKLCGHTLPRNWV-SSRGLMYLKFHTEGGSGYMGFKAKYSIVSCGGTVSGDSGVIESVGYP------------TRLYANNVF-----CQWHIQGLPGHYLTIRFEDFNLQSSPGCAKDFVEIWENHTSGILLGRY 2410

HSP 4 Score: 51.2174 bits (121), Expect = 5.510e-6
Identity = 26/82 (31.71%), Postives = 46/82 (56.10%), Query Frame = 1 
Query:  316 APSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYK 561
            A SP   + L F  +F++E+S++C  DF++I +G     +L+ ++CG  +         + LW+RF SD + T  GF+  +K
Sbjct: 1769 ASSPGNHLQLSFL-SFQLENSLNCNKDFVEIREG-NATGHLMGRYCGNSLPGNYSSIEGHNLWVRFVSDGSGTGMGFQARFK 1848

HSP 5 Score: 50.8322 bits (120), Expect = 5.557e-6
Identity = 55/218 (25.23%), Postives = 87/218 (39.91%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQ 957
            II+A  P   I L F   F ++ S DC  DF++I DG    + +  ++CGT +    I S  N L +RF SD      GF  IY  S        T  C    Y            +        ++    EC+++I+   G+++ ++ LS   + S+     F+EI +      ++ RY    L    S+ E      H   +R       + M FQ
Sbjct: 1650 IIEAQPPFNHIALSFTH-FHLQSSTDCTRDFVEILDGRDSDAPVQGRYCGTSLPHPII-SFGNALTVRFVSDSVYGFDGFHAIYSAS--------TSACGGTFYT--------GDGIFNSPGYPEDYHSNTECVWNIASSPGNHLQLSFLSFQLENSLNCNKDFVEIREGNATGHLMGRYCGNSLPGNYSSIEG-----HNLWVRFVSDGSGTGMGFQ 1844
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. UniProt/SwissProt
Match: sp|Q8BNJ6|NETO2_MOUSE (Neuropilin and tolloid-like protein 2 OS=Mus musculus OX=10090 GN=Neto2 PE=1 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 1.035e-19
Identity = 75/263 (28.52%), Postives = 126/263 (47.91%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L+I DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T       P   C  ++   +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F     ++   V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDERYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGMK-SPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFEL---SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSAIENLKAKFCSTVAND---VMLKTGVGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 328
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. UniProt/SwissProt
Match: sp|C6K2K4|NETO2_RAT (Neuropilin and tolloid-like protein 2 OS=Rattus norvegicus OX=10116 GN=Neto2 PE=1 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 1.588e-19
Identity = 74/263 (28.14%), Postives = 126/263 (47.91%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T       P   C  ++   +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F     ++   V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDERYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGMK-SPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFEL---SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSAIENLKAKFCSTVAND---VMLKTGVGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 328
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. UniProt/SwissProt
Match: sp|Q8NC67|NETO2_HUMAN (Neuropilin and tolloid-like protein 2 OS=Homo sapiens OX=9606 GN=NETO2 PE=1 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 3.069e-19
Identity = 74/263 (28.14%), Postives = 126/263 (47.91%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            +P   I L F E + IE S +C  D L++ DGPFGFS LI ++CG + S   I+ST  ++W++F SD+     GF+  Y F    + T       P   C  ++   +    ++ S+ +++ + T   + + +CI+ I     + I++  L    + S      F+ +YD   G   ++  K  F    ++    V LK    VIR+       +  F+++ T+ V     C+S  F C  + CI+ +LVCN ++NC    DE
Sbjct:   79 APRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVK-SPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFEL---SGADGIVRSSQVEQEEKTKPGQAV-DCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYD---GSSSIENLKAKFC---STVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDE 328
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. UniProt/SwissProt
Match: sp|Q8R4I7|NETO1_MOUSE (Neuropilin and tolloid-like protein 1 OS=Mus musculus OX=10090 GN=Neto1 PE=1 SV=2)

HSP 1 Score: 94.7449 bits (234), Expect = 4.659e-19
Identity = 81/289 (28.03%), Postives = 129/289 (44.64%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE-ICEGQFVNKIAGITSLTATTG 1152
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I +FCG + +   I+S+  +LW++F++D    + GF   Y F+   +       +P   C  +M  P      +      K   +       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F    ++    V L+    VIR+          FQ++ T+       C    F C  + CI+ TLVCN L+NC    DE  C+ +   K + +  LT T+G
Sbjct:   71 IIEA-APRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGVLKPLPACEFEMGGPEGIVESIQILKEGKASASEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKAKFC---STVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSF--QEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK--RKTSLLDQLTNTSG 343
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. UniProt/SwissProt
Match: sp|Q8TDF5|NETO1_HUMAN (Neuropilin and tolloid-like protein 1 OS=Homo sapiens OX=9606 GN=NETO1 PE=2 SV=2)

HSP 1 Score: 90.1225 bits (222), Expect = 1.177e-17
Identity = 80/289 (27.68%), Postives = 128/289 (44.29%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE-ICEGQFVNKIAGITSLTATTG 1152
            II+A +P   I L F E + IE S +C  D +++ DGPFGFS +I +FCG + +   I+S+  +LW++F++D    + GF   Y F+   +       +P   C  +M         +      K   +       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F    ++    V L+    VIR+          FQ++ T+       C    F C  + CI+ TLVCN L+NC    DE  C+ +   K + +  LT T+G
Sbjct:   71 IIEA-APRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAV----DCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKAKFC---STVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSF--QEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK--RKTSLLDQLTNTSG 343
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. TrEMBL
Match: A0A4D6G2K7 (Uncharacterized protein (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 480.33 bits (1235), Expect = 1.573e-164
Identity = 272/274 (99.27%), Postives = 272/274 (99.27%), Query Frame = 1 
Query:  856 LINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEICEGQFVNKIAGITSLTATTGRSENIQTFHFYRTHGYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLTTTVLCKKQYTQPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEFEIFSKSISNINQFTSKGTREHLPGCTSLPNFST 1677
            LINENSNFEKV LKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEICEGQFVNKIAGITSLTATTGRSENIQTFHFYRTHGYILGSITLLLVCLLIGCIIHSIKQSKIHSKTIKGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLT TVLCKKQYTQPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEFEIFSKSISNINQFTSKGTREHLPGCTSLPNFST
Sbjct:    2 LINENSNFEKVXLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEICEGQFVNKIAGITSLTATTGRSENIQTFHFYRTHGYILGSITLLLVCLLIGCIIHSIKQSKIHSKTIKGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLTATVLCKKQYTQPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEFEIFSKSISNINQFTSKGTREHLPGCTSLPNFST 275
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. TrEMBL
Match: A0A267G2I7 (CUB domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig021742g1 PE=4 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 1.405e-23
Identity = 80/284 (28.17%), Postives = 126/284 (44.37%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLIS---------KFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKG--------IEECIFDISVKKGSNIFVALSQLN-KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYH----RAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEI 1092
            +IKA  P   I L+FR  F IE+S  C  D+L++ DGP+G+S L+S         ++CG +   + ++S+  YLWLRF SD+   + G   +YKF          + C  ++ +P     ++ +      QL   F            +C  D+S    + + V+L  L  +       Q + +YD  T    VD  +++ L       E +  ++     RAVI +  K    +  F +V T +VR      S EF C    CI   LVCN+  NC    DE+
Sbjct:  100 VIKAEHPQQVIELDFRGEFHIEESSGCAADYLEVRDGPYGYSPLLSNQNGGSSNGRYCGAKPPSQRLKSSGRYLWLRFKSDEVIEHRGVSAVYKFVRPAAEAAVKQECVLELQLPVGHQEVVLTR-----QLREKFPPDYLAEPTTPVDCSVDVSSPDDTQVLVSLENLQVRRDDLCKQQAVYVYDAFT----VDLRRDFALCR---TLEPMTWRHRASKGRAVIHVTSKDTYLIPKFMVVFT-VVRKGTCQESTEFDCGSEHCIDSRLVCNSHVNCLDGSDEL 370
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. TrEMBL
Match: A0A0R1EHL8 (Uncharacterized protein, isoform D OS=Drosophila yakuba OX=7245 GN=Dyak\GE17077 PE=4 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 7.465e-23
Identity = 85/272 (31.25%), Postives = 136/272 (50.00%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFV-----ALSQLNKTSMTGLGQFIEIY-DRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVM--TFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCP-SADDEIC 1095
            +I AP   + I L+FR +F IE    C  DFL+I DG +GFS+LI KFCGT+   E I S   YLWL F+SD+T   +GF  +Y++ +   +   T +            +       + ++  N+ K   +CI+ I VK+   IF+      LS+ N         F++I+ ++   PL   R KN+      S  E +  + +  ++ ++F   ++ +  TF ++ TA       C+ +E+ C+ + CISK L CNNL NC    D+E C
Sbjct:  175 VITAPKGQI-IRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSSLIGKFCGTDFPPE-ITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTIDKGGFEGFINSTDVPAEIWEQVNHNKIALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQT----NFLDIFPEQTVMPL---RVKNFC----GSAGESITAESN--ILHLRFYADQTAINSTFGILFTAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 431
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. TrEMBL
Match: A0A267G6D3 (CUB domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017019g1 PE=4 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 7.670e-23
Identity = 79/284 (27.82%), Postives = 125/284 (44.01%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLIS---------KFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKG--------IEECIFDISVKKGSNIFVALSQLN-KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYH----RAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEI 1092
            +IKA  P   I L+FR  F IE+S  C  D+L++ DGP+G+S L+S         ++CG +   + ++S+  YLWLRF SD+   + G   +YKF          + C  ++ +P     ++ +      QL   F            +C  D+S    + + V+L  L  +       Q + +YD  T    VD  +++ L       E +  ++     RAVI +  K    +    +V T +VR      S EF C    CI   LVCN+  NC    DE+
Sbjct:  101 VIKAEHPQQVIELDFRGEFHIEESSGCAADYLEVRDGPYGYSPLLSNQNGGSSNGRYCGAKPPSQRLKSSGRYLWLRFKSDEVIEHRGVSAVYKFVRPAAAAAVKQECVLELQLPVGHQEVVLTR-----QLREKFPPDYLAEPTTPVDCSVDVSSPDDTQVLVSLENLQVRRDDLCKQQAVYVYDAFT----VDLRRDFALCR---TLEPMTWRHRASKGRAVIHVTSKDTYLIPKLMVVFT-VVRKGTCQESTEFDCGSEHCIDSRLVCNSHVNCLDGSDEL 371
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. TrEMBL
Match: A0A0R1E9Y1 (Uncharacterized protein, isoform C OS=Drosophila yakuba OX=7245 GN=Dyak\GE17077 PE=4 SV=1)

HSP 1 Score: 113.235 bits (282), Expect = 8.576e-23
Identity = 85/272 (31.25%), Postives = 136/272 (50.00%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFV-----ALSQLNKTSMTGLGQFIEIY-DRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVM--TFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCP-SADDEIC 1095
            +I AP   + I L+FR +F IE    C  DFL+I DG +GFS+LI KFCGT+   E I S   YLWL F+SD+T   +GF  +Y++ +   +   T +            +       + ++  N+ K   +CI+ I VK+   IF+      LS+ N         F++I+ ++   PL   R KN+      S  E +  + +  ++ ++F   ++ +  TF ++ TA       C+ +E+ C+ + CISK L CNNL NC    D+E C
Sbjct:  175 VITAPKGQI-IRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSSLIGKFCGTDFPPE-ITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTIDKGGFEGFINSTDVPAEIWEQVNHNKIALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQT----NFLDIFPEQTVMPL---RVKNFC----GSAGESITAESN--ILHLRFYADQTAINSTFGILFTAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 431
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Cavefish
Match: neto1 (neuropilin and tolloid-like protein 1 [Source:NCBI gene;Acc:103038528])

HSP 1 Score: 97.0561 bits (240), Expect = 7.380e-21
Identity = 75/267 (28.09%), Postives = 122/267 (45.69%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNS---KENTQP--TKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLN-KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+A SP   I+L F E + IE S +C  D +++ DGPF FS +I ++CG + S   ++S+  YLW++F +D     +GF   Y F+     K+   P    +C  +M  P      +  +   + Q T       +C + I    G+ I++   +   + S      F+ +YD   G   V+  KN F    ++    V L     VIR+          F+++ T    +   C  + F C  + CI+ TLVCN ++NC    DE
Sbjct:   75 IIEA-SPRQCIDLYFDEKYSIEPSWECKFDHIEVRDGPFSFSPIIGRYCGQQ-SPMYVRSSGRYLWIKFVADSELEATGFSARYNFTQDPDFKDIKTPLSLPVCEFEMSGPEGIVESVMVSKEGRAQQTEAV----DCRWFIRAPPGAKIYLRFLEYEMQNSNECKRNFVAVYD---GSSSVEHLKNKFC---STVANDVMLLTSVGVIRMWADEGSRKSRFRILFTTF--HAPPCEGDTFFCHSNMCINHTLVCNGIQNCVYPWDE 327
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Cavefish
Match: neto2b (neuropilin and tolloid-like protein 2 [Source:NCBI gene;Acc:103034665])

HSP 1 Score: 94.7449 bits (234), Expect = 5.510e-20
Identity = 76/265 (28.68%), Postives = 119/265 (44.91%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFS-------NSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIE--ECIFDISVKKGSNIFVALSQLN-KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            P   I L F E F IE S +C  D L+I DGPFGFS LI++FCG++ S  T+ ST  ++W++F SD+     GF+V Y F+       +      P   C  ++  P             + +  N  K  E  +CI+ I     + IF+   +   + S      F+ +YD   G   ++  K  F    ++    + L     V+R+       +  F+++ T        C S  F C  + CI++TLVCN ++NC    DE
Sbjct:   73 PRNRIELVFDENFFIEPSFECRFDHLEIRDGPFGFSPLINRFCGSQ-SPGTVASTGRFMWIKFTSDEELEGMGFRVEYTFTVDPDFHLHEGGLLNPIPDCQFELNGP------DGLIRSSQVEEENKVKSDEAVDCIWTIRAPPNNRIFLRFLEYQLENSNECKKNFVAVYD---GSNAIEDLKAKFC---STVANDLMLDNEVGVVRMWADETSRLSRFRMLFTFFAD--PPCMSNAFFCDTNMCINQTLVCNGIQNCVFPWDE 322
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Cavefish
Match: neto1l (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:103046598])

HSP 1 Score: 92.8189 bits (229), Expect = 1.815e-19
Identity = 75/267 (28.09%), Postives = 117/267 (43.82%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+AP P   I+L F E + IE S +C  D +++ DGPFGFS +I ++CG + S + I+S+  YLW++F +D      GF   Y F+   +       +P   C  +M  P             K   T       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F     S+   V L     V+R+          F+++ T        C ++ F C  + CI+ +LVCN ++NC    DE
Sbjct:   70 IIEAP-PRQCIDLFFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRYCGQQ-SPQYIRSSGRYLWIKFVADGELEAIGFSANYNFTADPDFKDMGIPKPLPFCEFEMGGPEGIIESQQITKDGKASPTEAV----DCKWFIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKVKFCSTVASD---VMLLSALGVVRMWADEGSRRSRFKILFTTF--QEPPCEADTFFCHSNMCINNSLVCNGIQNCVYPWDE 322
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Cavefish
Match: neto1l (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:103046598])

HSP 1 Score: 92.8189 bits (229), Expect = 2.019e-19
Identity = 75/267 (28.09%), Postives = 117/267 (43.82%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVA-LSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            II+AP P   I+L F E + IE S +C  D +++ DGPFGFS +I ++CG + S + I+S+  YLW++F +D      GF   Y F+   +       +P   C  +M  P             K   T       +C + I     S I++  L    + S      F+ +YD   G   V+  K  F     S+   V L     V+R+          F+++ T        C ++ F C  + CI+ +LVCN ++NC    DE
Sbjct:   70 IIEAP-PRQCIDLFFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRYCGQQ-SPQYIRSSGRYLWIKFVADGELEAIGFSANYNFTADPDFKDMGIPKPLPFCEFEMGGPEGIIESQQITKDGKASPTEAV----DCKWFIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYD---GSSSVEDLKVKFCSTVASD---VMLLSALGVVRMWADEGSRRSRFKILFTTF--QEPPCEADTFFCHSNMCINNSLVCNGIQNCVYPWDE 322
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Cavefish
Match: neto2b (neuropilin and tolloid like 2 [Source:NCBI gene;Acc:103023182])

HSP 1 Score: 91.6633 bits (226), Expect = 4.637e-19
Identity = 72/283 (25.44%), Postives = 118/283 (41.70%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIEIYDRITGPL---VVDRYKNYFLINENS---NFEKVY----------------------LKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            P   I L F + + IE S +C  D L++ DGPFGFS LI ++CG + S   + ST  ++W++F +D+     GF+V Y +    +                            K  +      I +C F++S   G + FV  SQ+++     +G+ ++    I  P    +  R+  Y + N N    NF  VY                      L+    V+R+       +  F+++ T+ V     CS   F C  + CI+ +LVCN ++NC    DE
Sbjct:   72 PRQRIQLVFDKNYYIEPSFECRFDHLELRDGPFGFSPLIDRYCGPK-SPGVVTSTGRFMWIKFLTDEELEGLGFRVKYTYIADPDF---------------------------KLHVGGLLNPIPDCQFEVS---GPDGFVRSSQVDEEEKVKVGEALDCIWTIRAPPQSKIYLRFLEYQMENSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLETGVGVVRMWADETSRLSRFRMLFTSFVD--PPCSGNTFFCHSNMCINNSLVCNGVQNCVYPWDE 321
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Sea Lamprey
Match: NETO2 (neuropilin and tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:14644])

HSP 1 Score: 75.485 bits (184), Expect = 2.719e-15
Identity = 36/86 (41.86%), Postives = 50/86 (58.14%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKF 564
            I++AP P     L F E + +E S +C  D L++ DGPF FS LI +FCGTE     I S   ++W++FYSD    + GF+  Y F
Sbjct:   34 ILEAP-PRQRTELHFDEPYSVEPSWECKFDHLEVRDGPFSFSPLIGRFCGTE-RPPPITSNGRFMWIKFYSDGELESMGFRAYYTF 117
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007646.1 (pep scaffold:Pmarinus_7.0:GL489134:1272:7172:1 gene:ENSPMAG00000006907.1 transcript:ENSPMAT00000007646.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.0922 bits (170), Expect = 2.951e-14
Identity = 31/86 (36.05%), Postives = 51/86 (59.30%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKF 564
            I++AP+    I L F   + +E S DC  D +++ DGPFGFS LI +FCG  + +  + ST  ++W++F++D      GF+  + F
Sbjct:   44 ILEAPA-RQRIELSFSAPYSLEPSWDCKFDHIEVRDGPFGFSPLIGRFCGHVLPR-PVNSTGRFMWVKFFADSELEALGFRARFTF 127
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003059.1 (pep scaffold:Pmarinus_7.0:GL476485:229541:264028:1 gene:ENSPMAG00000002790.1 transcript:ENSPMAT00000003059.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 3.313e-8
Identity = 27/93 (29.03%), Postives = 48/93 (51.61%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT 585
            +++A  P   + L F   F+IE   DC  D++++ DG    +  + +FCG+ ++   I S+   L +RF SD T   +GF + Y+   S  + 
Sbjct:   13 LLRAAGPGQRLALAFNPHFDIEKH-DCRFDYVEVRDGEGDAAEAMGRFCGS-VAPAPIVSSGPALLIRFVSDYTNQGAGFSLRYEIHKSGSDA 103
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007253.1 (pep scaffold:Pmarinus_7.0:GL476910:54360:144194:-1 gene:ENSPMAG00000006538.1 transcript:ENSPMAT00000007253.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 3.610e-8
Identity = 28/72 (38.89%), Postives = 43/72 (59.72%), Query Frame = 1 
Query:  337 INLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKV 552
            + L F + FEIE   +C  D+L++ DG    S LI ++CG E   + I+S+SN LW++F SD +   +GF  
Sbjct:  365 VGLTF-QAFEIEKHDNCAYDYLEVRDGDNDSSQLIGRYCGYE-KPDDIKSSSNKLWMKFVSDSSVNKAGFAA 434

HSP 2 Score: 51.9878 bits (123), Expect = 3.748e-7
Identity = 39/98 (39.80%), Postives = 55/98 (56.12%), Query Frame = 1 
Query:  310 IKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKIC 603
            + AP+    I+L+F E FE+E +  C  D+++I  G    S L  KFCGTE+  + I S +N L L F SD T +  GFKV + FS+  E +Q    C
Sbjct:  513 VVAPA-QYRISLQF-EFFELEGNDVCKYDYVEIRSGLSSESKLHGKFCGTELP-DVITSQNNNLRLEFKSDNTVSKKGFKVHF-FSDKDECSQHNGGC 606

HSP 3 Score: 51.9878 bits (123), Expect = 4.154e-7
Identity = 27/79 (34.18%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIY 558
            +P   + L F E FE+E   +C  D L++ DG    + ++ +FCG++   E + ST N ++LRF SD +    GF+ I+
Sbjct:  675 TPGHRVKLTFSE-FEVEQHQECAYDHLEVYDGSSEKAPILGRFCGSK-KPEAVLSTLNKMYLRFMSDASVQKRGFQAIH 751
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001629.1 (pep scaffold:Pmarinus_7.0:GL476369:34656:293612:-1 gene:ENSPMAG00000001441.1 transcript:ENSPMAT00000001629.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 5.293e-8
Identity = 31/78 (39.74%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIY 558
            P M I L  R TF +        D L+I DG  G + L++ F  +E++ +TI STSN+LWL F +D   T+ GF+++Y
Sbjct: 1103 PGMGIRLTAR-TFRLGPG-----DSLKIYDGRDGSARLMNAFTTSELNGKTINSTSNHLWLEFNTDSQGTDIGFQILY 1174
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Nematostella
Match: EDO47760 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKX7])

HSP 1 Score: 60.4622 bits (145), Expect = 2.363e-10
Identity = 30/80 (37.50%), Postives = 44/80 (55.00%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYK 561
             P   I L   ET +IE S  C  D L+INDGP   S  +  FCGT+  K  I+S+ N ++++  SD  +T  GF+  ++
Sbjct:   36 GPKQAIELTI-ETIDIEQSKKCRYDSLEINDGPNSKSPELGAFCGTKPPKAAIRSSGNSMYVKLTSDDGDTGKGFRATWR 114
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Nematostella
Match: EDO41783 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3J5])

HSP 1 Score: 60.4622 bits (145), Expect = 1.379e-9
Identity = 27/59 (45.76%), Postives = 39/59 (66.10%), Query Frame = 1 
Query:  385 CFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYK 561
            C NDF+++ DG    SNLI +FCGT +   +I ST + LW++F SD  E+  GFK +Y+
Sbjct:  265 CKNDFVEVRDGHGRESNLIGRFCGTRVP-PSIWSTGSRLWIKFKSDGVESRPGFKAVYE 322

HSP 2 Score: 53.1434 bits (126), Expect = 3.314e-7
Identity = 29/79 (36.71%), Postives = 43/79 (54.43%), Query Frame = 1 
Query:  310 IKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGF 546
            I  P     + + F   F++ED   C  D+LQ+ DG   ++  I KFCG EI  E ++S S+YL ++F SD +    GF
Sbjct:  355 IALPGKGSRVGMRF-VAFDVEDHEQCHYDYLQLFDGQDEWAPSIGKFCGKEIPGE-VRSNSSYLTIKFKSDASINKPGF 431
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Nematostella
Match: EDO50070 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFB6])

HSP 1 Score: 55.8398 bits (133), Expect = 1.814e-8
Identity = 29/69 (42.03%), Postives = 43/69 (62.32%), Query Frame = 1 
Query:  355 ETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYK 561
            E  ++  S  C +D L++ DGP   S LI ++CG  I  + +QS+ N L ++F SD TET  GFKV+Y+
Sbjct:  140 EFLDLAYSSACSDDALEVWDGPVRNSALIGRYCGYMIG-QWVQSSGNELTVQFRSDLTETRRGFKVLYR 207
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Nematostella
Match: EDO33377 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSB6])

HSP 1 Score: 52.373 bits (124), Expect = 1.999e-8
Identity = 25/66 (37.88%), Postives = 40/66 (60.61%), Query Frame = 1 
Query:  367 IEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKF 564
            ++D V C  D++ ++DG    S LI ++CG  I  E I+STSN++ + F+SD      G K +Y+F
Sbjct:   48 LQDHVTCAKDYVAVHDGSDVASPLIGRYCGF-IHPELIESTSNHMTILFHSDAQFHKRGLKALYRF 112
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Nematostella
Match: EDO49858 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7REV9])

HSP 1 Score: 56.6102 bits (135), Expect = 2.205e-8
Identity = 56/273 (20.51%), Postives = 116/273 (42.49%), Query Frame = 1 
Query:  322 SPSMTINLEFRETFEIE------DSVDCFNDFLQIND-GPFGFSNLISK-------FCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLN--KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEI 1092
            +P   I +EF  TF++E       + +C +D++++ +     +S  ISK       +CG ++      +  +++WLRF SD +  + GF   ++  +  E +   K+  ++ ++             + Y     F   +EC ++I V+K  +I +     N  +     +  ++++YD      V+ ++    +        KV  + ++ V+R    + +   T       LV +   C  ++F C+   CI     CNN ++C    DEI
Sbjct:  174 APLGRIKIEF-GTFDLETLPGQTQTTECESDYVEVKEIEHVEYSTSISKPSARFRRYCGNQLPPTVYSTLGSHIWLRFKSDSSGESKGFSARFRTVSVGEGSCEGKLSGKRGHL-----------FSQNYPFL--FPRNKECSWEIEVEKNMHIHLFFDTFNFSRHHQQCIYGYVQVYDGPGHASVIGQFCGAVMPT------KVVSRSNKLVVRA--LSGDGANTGWFSARYLVSSEGPCGPKKFTCQNRQCIDDFKQCNNRQDCRDGSDEI 424

HSP 2 Score: 48.521 bits (114), Expect = 6.156e-6
Identity = 27/59 (45.76%), Postives = 38/59 (64.41%), Query Frame = 1 
Query:  385 CFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSD-KTETNSGFKVIY 558
            C +DF+++ DG    S+LI +FC   + K  I STSN LWLRF SD +TE  + F++ Y
Sbjct:   81 CKHDFVELRDGNSVNSSLIGRFCAQNLPK-IIYSTSNTLWLRFQSDFRTEIENKFRLTY 138
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Medaka
Match: neto1l (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:101167749])

HSP 1 Score: 90.8929 bits (224), Expect = 8.998e-19
Identity = 72/271 (26.57%), Postives = 121/271 (44.65%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFK-GIEE---CIFDISVKKGSNIFVALSQLNKTSMTGLGQ-FIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            I++AP P   ++L F E + IE S +C  D +++ DGPF FS ++ ++CG   S   I+S+  YLW++F +D      GF   Y F+   +        P   C   M  P          +++ +Q+T + K G  E   C + I     S I++        +     + F+ +YD   G   V+  K+ F    ++    + L     V+R+    +     F+++ T        C ++ F C  + CI+ TLVCN L+NC    DE
Sbjct:   71 ILEAP-PRQCLDLHFEENYSIESSWECKFDNIEVRDGPFSFSPILGRYCGQH-SPPDIRSSGRYLWIKFETDGELEGVGFSASYNFTADPDFGDLGVPPPLPSCQYDMVGP--------EGIVESHQITRDGKAGAAEAVDCKWYIRAPPRSKIYLRFLDYEMANSNECKRNFVAVYD---GGSSVEDLKSKFC---STVANDIMLVSTLGVVRMWADELSRKSRFRILFTTF--QEPPCDADAFFCHSNMCINYTLVCNGLQNCVYPWDE 323
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Medaka
Match: neto1l (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:101167749])

HSP 1 Score: 90.8929 bits (224), Expect = 9.322e-19
Identity = 72/271 (26.57%), Postives = 121/271 (44.65%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFK-GIEE---CIFDISVKKGSNIFVALSQLNKTSMTGLGQ-FIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            I++AP P   ++L F E + IE S +C  D +++ DGPF FS ++ ++CG   S   I+S+  YLW++F +D      GF   Y F+   +        P   C   M  P          +++ +Q+T + K G  E   C + I     S I++        +     + F+ +YD   G   V+  K+ F    ++    + L     V+R+    +     F+++ T        C ++ F C  + CI+ TLVCN L+NC    DE
Sbjct:   71 ILEAP-PRQCLDLHFEENYSIESSWECKFDNIEVRDGPFSFSPILGRYCGQH-SPPDIRSSGRYLWIKFETDGELEGVGFSASYNFTADPDFGDLGVPPPLPSCQYDMVGP--------EGIVESHQITRDGKAGAAEAVDCKWYIRAPPRSKIYLRFLDYEMANSNECKRNFVAVYD---GGSSVEDLKSKFC---STVANDIMLVSTLGVVRMWADELSRKSRFRILFTTF--QEPPCDADAFFCHSNMCINYTLVCNGLQNCVYPWDE 323
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Medaka
Match: neto1l (neuropilin and tolloid like 1 [Source:NCBI gene;Acc:101167749])

HSP 1 Score: 90.8929 bits (224), Expect = 9.386e-19
Identity = 72/271 (26.57%), Postives = 121/271 (44.65%), Query Frame = 1 
Query:  307 IIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKE-----NTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFK-GIEE---CIFDISVKKGSNIFVALSQLNKTSMTGLGQ-FIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            I++AP P   ++L F E + IE S +C  D +++ DGPF FS ++ ++CG   S   I+S+  YLW++F +D      GF   Y F+   +        P   C   M  P          +++ +Q+T + K G  E   C + I     S I++        +     + F+ +YD   G   V+  K+ F    ++    + L     V+R+    +     F+++ T        C ++ F C  + CI+ TLVCN L+NC    DE
Sbjct:   71 ILEAP-PRQCLDLHFEENYSIESSWECKFDNIEVRDGPFSFSPILGRYCGQH-SPPDIRSSGRYLWIKFETDGELEGVGFSASYNFTADPDFGDLGVPPPLPSCQYDMVGP--------EGIVESHQITRDGKAGAAEAVDCKWYIRAPPRSKIYLRFLDYEMANSNECKRNFVAVYD---GGSSVEDLKSKFC---STVANDIMLVSTLGVVRMWADELSRKSRFRILFTTF--QEPPCDADAFFCHSNMCINYTLVCNGLQNCVYPWDE 323
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Medaka
Match: neto2b (neuropilin and tolloid-like protein 2 [Source:NCBI gene;Acc:101158440])

HSP 1 Score: 86.2705 bits (212), Expect = 2.431e-17
Identity = 70/280 (25.00%), Postives = 113/280 (40.36%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINEN---SNFEKVY----------------------LKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            P   I L F + F+IE S +C  D +++ DGPF FS LI ++CG+  S   I S+  ++W+RFYSD     SGF V YKF+   E                               +      I +C F+++   G +  +  +Q+ + +     Q ++    I  P+ + R+  Y + N N    NF  +Y                      L     V+R+       +  F+++ T        C    F C  + CI+ +LVCN ++NC    DE
Sbjct:   61 PRQRIELLFNKLFQIEPSFECRFDHIEVRDGPFSFSPLIKRYCGSA-SPGRIFSSGRFMWIRFYSDDELEGSGFYVQYKFTADPE---------------------------FHLHVGGLLNPIPDCQFEVT---GLDGLIRSTQVEEENKLNPDQAVDCIWTIRAPIYL-RFLEYQMENSNECKKNFVAIYDGSSAIEDLKAKFCSTVANDVMLDTSFGVVRMWADETSRLSRFRMLFTIFYD--PPCMGNTFFCHSNMCINNSLVCNGMQNCVFPWDE 306
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Medaka
Match: neto2b (neuropilin and tolloid like 2 [Source:NCBI gene;Acc:101166540])

HSP 1 Score: 82.8037 bits (203), Expect = 2.883e-16
Identity = 65/263 (24.71%), Postives = 115/263 (43.73%), Query Frame = 1 
Query:  325 PSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT-------QPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLN-KTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDE 1089
            P   I L F + + IE S +C  D +++ DGPFGFS LI +FCG + +   + ST  ++W++F SD+     GF+V Y F    +          P   C  ++   +           ++ +  +      +CI+ I     S I++       + S      F+ +YD   G   ++  K  F    ++    + L     V+R+       +  F+++ T+ +     C++  F C  + CI+ TLVCN ++NC    DE
Sbjct:   60 PRQRIQLSFDKNYYIEPSFECRFDHIEVRDGPFGFSPLIDRFCGGK-NPGLVTSTGRFMWIKFTSDEELEGLGFRVTYTFIADPDFHLHVGGLLNPIPDCQFEVGGWDGIIRSSQVEEEERVKPGDAL----DCIWTIRAPPQSKIYLRFIDYQMEHSNECKKNFVAVYD---GSSAIENLKAKFC---STVANDLMLDNGVGVVRMWADEKSRLSRFRMLFTSYID--PPCTANTFFCHSNMCINNTLVCNGVQNCVYPWDE 309
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Planmine SMEST
Match: SMESG000028496.1 (SMESG000028496.1)

HSP 1 Score: 998.038 bits (2579), Expect = 0.000e+0
Identity = 560/566 (98.94%), Postives = 562/566 (99.29%), Query Frame = 1 
Query:   52 IFNNSQISDMIAEILFVQLLVLYEKSEQISSLIDDNHFIEVLSQQTICRDFITPIPISDLSLDREYSLQSXXXXXXXXXXXXXXXIIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQPTKICYQKMYIPXXXXXXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEICEGQFVNKIAGITSLTATTGRSENIQTFHFYRTHGYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLTTTVLCKKQYTQPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEFEIFSKSISNINQFTSKGTREHLPGCTSLPNFSTESVKNLFEDEDYPIVEEVTINKPI 1749
            IFNNSQISDMIAEILFVQLLVLYEKSEQIS LIDDNHFIEVLSQQTICRDFITPIPISDLSLDREYSLQSPNYPNNYPVNVDCVYIIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENT+PTKICYQKMYIPNSESVLLNSNLLKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKY RAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCP ADDEICEGQ VNKIAGITSLTATTG+SENIQTFHFYRTHGYILGSITLLLVCLLIGCIIHSIKQSKIHSKTIKGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLTTTVLCKKQYTQPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEFEIFSKSISNINQFTSKGTREHLPGCTSLPNFSTESVKNLFEDEDYPIVEEVTINKPI
Sbjct:   81 IFNNSQISDMIAEILFVQLLVLYEKSEQISGLIDDNHFIEVLSQQTICRDFITPIPISDLSLDREYSLQSPNYPNNYPVNVDCVYIIKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTEPTKICYQKMYIPNSESVLLNSNLLKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIEIYDRITGPLVVDRYKNYFLINENSNFEKVYLKYQRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPLADDEICEGQLVNKIAGITSLTATTGKSENIQTFHFYRTHGYILGSITLLLVCLLIGCIIHSIKQSKIHSKTIKGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLTTTVLCKKQYTQPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEFEIFSKSISNINQFTSKGTREHLPGCTSLPNFSTESVKNLFEDEDYPIVEEVTINKPI 646
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Planmine SMEST
Match: SMESG000018087.1 (SMESG000018087.1)

HSP 1 Score: 146.747 bits (369), Expect = 3.832e-39
Identity = 92/273 (33.70%), Postives = 145/273 (53.11%), Query Frame = 1 
Query:  310 IKAPSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQP-TKICYQKMYIPXXXX-----XXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQL--NKTSMTGLGQFIEIYDR--ITGPLVVDRYKNYFLINENSNF-EKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEIC 1095
            IK PS    I +E RE FE+E S DC +DFL+INDGP+GFS    KFC +E   + I ST  ++WLRF+SD +  +SGFK++Y+F   K+N +P    CY++  IP+ +S       L S      ++ +N     EC+FD  V    + FV  S+    K  ++    F+E++    +   +   +  NY+ I E+ +F E+++ K +R  +R+  K +  V  F+ ++T +      C     +C   +C+S  L+CN   NCP   DE C
Sbjct:    4 IKYPSYEYNIVIEVREKFELEPSKDCLSDFLEINDGPYGFSKSFGKFCSSESIPKEIVSTGPFIWLRFFSDSSLPHSGFKIVYRF--IKQNVKPIINYCYKQTIIPDDDSFNLNTSFLLSEFKNSTKVHDNASIPVECVFDFYVNPELSTFVHKSRFVKQKNFLSCQDNFLELFHSSTVNENIKPKKLSNYYKICEDQDFNERLFTKSYRTSVRVSLKDISKVDDFRFIITPIKIFESKCPEHFSRCDQLYCVSNKLMCNTETNCPLGTDEKC 274
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Planmine SMEST
Match: SMESG000018087.1 (SMESG000018087.1)

HSP 1 Score: 144.05 bits (362), Expect = 3.745e-38
Identity = 91/276 (32.97%), Postives = 148/276 (53.62%), Query Frame = 1 
Query:  307 IIKAPSPSMTINL--EFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQP-TKICYQKMYIPXXXX-----XXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQL--NKTSMTGLGQFIEIYDR--ITGPLVVDRYKNYFLINENSNF-EKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEIC 1095
            +I++ +PS   N+  E RE FE+E S DC +DFL+INDGP+GFS    KFC +E   + I ST  ++WLRF+SD +  +SGFK++Y+F   K+N +P    CY++  IP+ +S       L S      ++ +N     EC+FD  V    + FV  S+    K  ++    F+E++    +   +   +  NY+ I E+ +F E+++ K +R  +R+  K +  V  F+ ++T +      C     +C   +C+S  L+CN   NCP   DE C
Sbjct:    7 VIQSTNPSYEYNIVIEVREKFELEPSKDCLSDFLEINDGPYGFSKSFGKFCSSESIPKEIVSTGPFIWLRFFSDSSLPHSGFKIVYRF--IKQNVKPIINYCYKQTIIPDDDSFNLNTSFLLSEFKNSTKVHDNASIPVECVFDFYVNPELSTFVHKSRFVKQKNFLSCQDNFLELFHSSTVNENIKPKKLSNYYKICEDQDFNERLFTKSYRTSVRVSLKDISKVDDFRFIITPIKIFESKCPEHFSRCDQLYCVSNKLMCNTETNCPLGTDEKC 280
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Planmine SMEST
Match: SMESG000018087.1 (SMESG000018087.1)

HSP 1 Score: 143.665 bits (361), Expect = 3.999e-38
Identity = 90/270 (33.33%), Postives = 143/270 (52.96%), Query Frame = 1 
Query:  319 PSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQP-TKICYQKMYIPXXXX-----XXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQL--NKTSMTGLGQFIEIYDR--ITGPLVVDRYKNYFLINENSNF-EKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEIC 1095
            PS    I +E RE FE+E S DC +DFL+INDGP+GFS    KFC +E   + I ST  ++WLRF+SD +  +SGFK++Y+F   K+N +P    CY++  IP+ +S       L S      ++ +N     EC+FD  V    + FV  S+    K  ++    F+E++    +   +   +  NY+ I E+ +F E+++ K +R  +R+  K +  V  F+ ++T +      C     +C   +C+S  L+CN   NCP   DE C
Sbjct:    6 PSYEYNIVIEVREKFELEPSKDCLSDFLEINDGPYGFSKSFGKFCSSESIPKEIVSTGPFIWLRFFSDSSLPHSGFKIVYRF--IKQNVKPIINYCYKQTIIPDDDSFNLNTSFLLSEFKNSTKVHDNASIPVECVFDFYVNPELSTFVHKSRFVKQKNFLSCQDNFLELFHSSTVNENIKPKKLSNYYKICEDQDFNERLFTKSYRTSVRVSLKDISKVDDFRFIITPIKIFESKCPEHFSRCDQLYCVSNKLMCNTETNCPLGTDEKC 273
[Close]
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Planmine SMEST
Match: SMESG000018087.1 (SMESG000018087.1)

HSP 1 Score: 144.05 bits (362), Expect = 4.108e-38
Identity = 90/270 (33.33%), Postives = 143/270 (52.96%), Query Frame = 1 
Query:  319 PSPSMTINLEFRETFEIEDSVDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKTETNSGFKVIYKFSNSKENTQP-TKICYQKMYIPXXXX-----XXXXXXXXKKYQLTNNFKGIEECIFDISVKKGSNIFVALSQL--NKTSMTGLGQFIEIYDR--ITGPLVVDRYKNYFLINENSNF-EKVYLKYHRAVIRIKFKTVESVMTFQLVLTALVRNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEIC 1095
            PS    I +E RE FE+E S DC +DFL+INDGP+GFS    KFC +E   + I ST  ++WLRF+SD +  +SGFK++Y+F   K+N +P    CY++  IP+ +S       L S      ++ +N     EC+FD  V    + FV  S+    K  ++    F+E++    +   +   +  NY+ I E+ +F E+++ K +R  +R+  K +  V  F+ ++T +      C     +C   +C+S  L+CN   NCP   DE C
Sbjct:   14 PSYEYNIVIEVREKFELEPSKDCLSDFLEINDGPYGFSKSFGKFCSSESIPKEIVSTGPFIWLRFFSDSSLPHSGFKIVYRF--IKQNVKPIINYCYKQTIIPDDDSFNLNTSFLLSEFKNSTKVHDNASIPVECVFDFYVNPELSTFVHKSRFVKQKNFLSCQDNFLELFHSSTVNENIKPKKLSNYYKICEDQDFNERLFTKSYRTSVRVSLKDISKVDDFRFIITPIKIFESKCPEHFSRCDQLYCVSNKLMCNTETNCPLGTDEKC 281
The following BLAST results are available for this feature:
BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NETO26.392e-2028.14neuropilin and tolloid like 2 [Source:HGNC Symbol;... [more]
NETO21.664e-1927.46neuropilin and tolloid like 2 [Source:HGNC Symbol;... [more]
NETO12.451e-1827.68neuropilin and tolloid like 1 [Source:HGNC Symbol;... [more]
NETO12.451e-1827.68neuropilin and tolloid like 1 [Source:HGNC Symbol;... [more]
NETO13.558e-1439.08neuropilin and tolloid like 1 [Source:HGNC Symbol;... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
neto-19.041e-2027.24NETO (NEuropilin and TOlloid-like) homolog [Sourc... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Neto4.204e-2631.25gene:FBgn0265416 transcript:FBtr0339703[more]
Neto8.263e-2631.25gene:FBgn0265416 transcript:FBtr0339702[more]
Cubn4.696e-835.90gene:FBgn0052702 transcript:FBtr0273437[more]
CG422554.847e-838.46gene:FBgn0259140 transcript:FBtr0332131[more]
tld2.386e-637.27gene:FBgn0003719 transcript:FBtr0084691[more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
neto14.623e-2229.21neuropilin (NRP) and tolloid (TLL)-like 1 [Source:... [more]
neto17.651e-2228.63neuropilin (NRP) and tolloid (TLL)-like 1 [Source:... [more]
neto1l1.040e-1927.31neuropilin (NRP) and tolloid (TLL)-like 1, like [S... [more]
neto1l1.134e-1927.31neuropilin (NRP) and tolloid (TLL)-like 1, like [S... [more]
neto2b2.717e-1928.90neuropilin (NRP) and tolloid (TLL)-like 2b [Source... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NETO19.433e-2027.34neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
NETO19.620e-2027.34neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
neto28.644e-1926.24neuropilin and tolloid like 2 [Source:NCBI gene;Ac... [more]
neto23.983e-1825.89neuropilin and tolloid like 2 [Source:NCBI gene;Ac... [more]
neto24.989e-1825.89neuropilin and tolloid like 2 [Source:NCBI gene;Ac... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Neto21.479e-2028.52neuropilin (NRP) and tolloid (TLL)-like 2 [Source:... [more]
Neto24.403e-2028.40neuropilin (NRP) and tolloid (TLL)-like 2 [Source:... [more]
Neto25.671e-2028.40neuropilin (NRP) and tolloid (TLL)-like 2 [Source:... [more]
Neto16.660e-2028.03neuropilin (NRP) and tolloid (TLL)-like 1 [Source:... [more]
Cubn6.028e-928.48cubilin (intrinsic factor-cobalamin receptor) [Sou... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8BNJ6|NETO2_MOUSE1.035e-1928.52Neuropilin and tolloid-like protein 2 OS=Mus muscu... [more]
sp|C6K2K4|NETO2_RAT1.588e-1928.14Neuropilin and tolloid-like protein 2 OS=Rattus no... [more]
sp|Q8NC67|NETO2_HUMAN3.069e-1928.14Neuropilin and tolloid-like protein 2 OS=Homo sapi... [more]
sp|Q8R4I7|NETO1_MOUSE4.659e-1928.03Neuropilin and tolloid-like protein 1 OS=Mus muscu... [more]
sp|Q8TDF5|NETO1_HUMAN1.177e-1727.68Neuropilin and tolloid-like protein 1 OS=Homo sapi... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4D6G2K71.573e-16499.27Uncharacterized protein (Fragment) OS=Schmidtea me... [more]
A0A267G2I71.405e-2328.17CUB domain-containing protein OS=Macrostomum ligna... [more]
A0A0R1EHL87.465e-2331.25Uncharacterized protein, isoform D OS=Drosophila y... [more]
A0A267G6D37.670e-2327.82CUB domain-containing protein OS=Macrostomum ligna... [more]
A0A0R1E9Y18.576e-2331.25Uncharacterized protein, isoform C OS=Drosophila y... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
neto17.380e-2128.09neuropilin and tolloid-like protein 1 [Source:NCBI... [more]
neto2b5.510e-2028.68neuropilin and tolloid-like protein 2 [Source:NCBI... [more]
neto1l1.815e-1928.09neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
neto1l2.019e-1928.09neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
neto2b4.637e-1925.44neuropilin and tolloid like 2 [Source:NCBI gene;Ac... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NETO22.719e-1541.86neuropilin and tolloid like 2 [Source:HGNC Symbol;... [more]
ENSPMAT00000007646.12.951e-1436.05pep scaffold:Pmarinus_7.0:GL489134:1272:7172:1 gen... [more]
ENSPMAT00000003059.13.313e-829.03pep scaffold:Pmarinus_7.0:GL476485:229541:264028:1... [more]
ENSPMAT00000007253.13.610e-838.89pep scaffold:Pmarinus_7.0:GL476910:54360:144194:-1... [more]
ENSPMAT00000001629.15.293e-839.74pep scaffold:Pmarinus_7.0:GL476369:34656:293612:-1... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO477602.363e-1037.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO417831.379e-945.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO500701.814e-842.03Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO333771.999e-837.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO498582.205e-820.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
neto1l8.998e-1926.57neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
neto1l9.322e-1926.57neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
neto1l9.386e-1926.57neuropilin and tolloid like 1 [Source:NCBI gene;Ac... [more]
neto2b2.431e-1725.00neuropilin and tolloid-like protein 2 [Source:NCBI... [more]
neto2b2.883e-1624.71neuropilin and tolloid like 2 [Source:NCBI gene;Ac... [more]
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BLAST of Neuropilin (NRP) and tolloid (TLL)-like 2b vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000028496.10.000e+098.94SMESG000028496.1[more]
SMESG000018087.13.832e-3933.70SMESG000018087.1[more]
SMESG000018087.13.745e-3832.97SMESG000018087.1[more]
SMESG000018087.13.999e-3833.33SMESG000018087.1[more]
SMESG000018087.14.108e-3833.33SMESG000018087.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034627 ID=SMED30034627|Name=Neuropilin (NRP) and tolloid (TLL)-like 2b|organism=Schmidtea mediterranea sexual|type=transcript|length=1853bp
GTTATACATAATATTTCCATGAATTATTCAATCGAATTTTGCACAGTTTA
AATTTTCAACAACAGTCAAATCAGTGATATGATTGCTGAAATTTTATTTG
TCCAACTCCTGGTTTTATATGAAAAAAGCGAACAAATCTCAAGTTTAATT
GATGACAACCATTTTATTGAAGTACTTTCTCAACAAACAATTTGTCGTGA
TTTTATCACCCCTATTCCAATAAGTGATTTATCCTTGGACAGAGAATACA
GTTTACAGTCTCCAAATTATCCGAATAACTACCCAGTTAACGTTGATTGC
GTATATATTATCAAAGCTCCATCTCCTAGCATGACAATAAATTTAGAATT
TCGTGAAACATTTGAAATAGAAGATTCAGTAGATTGTTTTAATGATTTCT
TGCAAATAAATGATGGTCCTTTTGGGTTTTCTAATTTAATTTCTAAGTTT
TGTGGGACAGAAATATCTAAAGAAACAATTCAATCAACAAGCAATTATTT
GTGGCTTCGGTTTTATTCTGATAAAACAGAGACCAATAGTGGTTTTAAAG
TGATTTACAAATTTTCTAATTCAAAAGAAAACACTCAGCCAACAAAAATT
TGCTACCAGAAAATGTATATTCCTAATAGTGAATCGGTATTACTTAATAG
TAACCTTTTGAAGAAATACCAGCTTACAAATAACTTCAAAGGGATCGAGG
AGTGCATATTTGACATATCAGTCAAAAAAGGAAGCAATATTTTCGTTGCT
CTTTCTCAACTGAATAAAACATCCATGACTGGCTTGGGTCAATTCATCGA
GATTTATGACAGAATTACTGGCCCATTAGTTGTTGATCGTTACAAAAACT
ATTTTTTAATAAATGAAAATTCTAATTTTGAAAAAGTTTATCTTAAATAT
CATCGAGCGGTTATTCGAATTAAATTCAAAACAGTAGAATCCGTAATGAC
ATTTCAGTTGGTTTTGACAGCCCTTGTGAGAAATATGAAAAATTGCTCTT
CGGAAGAATTTCAATGCAAGGGCTCATTTTGCATATCAAAGACATTAGTC
TGCAACAATTTAAGAAACTGTCCCTCAGCGGACGATGAAATTTGCGAAGG
TCAATTTGTCAACAAAATTGCTGGAATAACTTCATTAACTGCCACAACAG
GAAGATCGGAAAATATTCAAACATTTCATTTTTATCGCACTCATGGATAT
ATACTGGGATCTATAACATTATTATTGGTTTGTTTGCTCATTGGATGTAT
AATACATTCAATTAAACAAAGTAAAATACACTCAAAAACGATTAAAGGTC
GAACTCTTAATTCAACTAATCAAATTCTCAAAAATACAACTATAAAATTT
GAAGAAAGTACATTGAAACCGTCAAATCCCAGCACTGCAACATTGACAAC
AACCGTATTGTGTAAAAAGCAATATACTCAGCCTAAAAACAAAAACCAAC
CAATCAAACAAATTAAATCGCATAATGAACCGGTTTCAATTTACTATAAG
GATTTTACACGTCATGAAAATGCGGAAATTTCAAATTCATCCAATCATCC
TACCCGAGACTCTTGTTCTCCAGAATTCGAGATTTTTTCCAAGTCAATAT
CAAATATTAATCAATTCACATCCAAAGGAACCCGTGAACATTTACCCGGT
TGTACCAGTCTGCCAAATTTTTCAACAGAATCTGTGAAGAATTTATTTGA
AGATGAAGATTACCCTATAGTAGAAGAAGTAACAATTAACAAACCAATTA
GAGTGAAATATTATGCCTAGAAATATTGATTTCGCTTTTTTGTTTAAATG
GATAAACCATTTATTGTTTGACTGTATATAATTTGAATCAAATTTAAAAC
TAA
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protein sequence of SMED30034627-orf-1

>SMED30034627-orf-1 ID=SMED30034627-orf-1|Name=SMED30034627-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=564bp
MIAEILFVQLLVLYEKSEQISSLIDDNHFIEVLSQQTICRDFITPIPISD
LSLDREYSLQSPNYPNNYPVNVDCVYIIKAPSPSMTINLEFRETFEIEDS
VDCFNDFLQINDGPFGFSNLISKFCGTEISKETIQSTSNYLWLRFYSDKT
ETNSGFKVIYKFSNSKENTQPTKICYQKMYIPNSESVLLNSNLLKKYQLT
NNFKGIEECIFDISVKKGSNIFVALSQLNKTSMTGLGQFIEIYDRITGPL
VVDRYKNYFLINENSNFEKVYLKYHRAVIRIKFKTVESVMTFQLVLTALV
RNMKNCSSEEFQCKGSFCISKTLVCNNLRNCPSADDEICEGQFVNKIAGI
TSLTATTGRSENIQTFHFYRTHGYILGSITLLLVCLLIGCIIHSIKQSKI
HSKTIKGRTLNSTNQILKNTTIKFEESTLKPSNPSTATLTTTVLCKKQYT
QPKNKNQPIKQIKSHNEPVSIYYKDFTRHENAEISNSSNHPTRDSCSPEF
EIFSKSISNINQFTSKGTREHLPGCTSLPNFSTESVKNLFEDEDYPIVEE
VTINKPIRVKYYA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000418head
PLANA:0003104enteric muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR035914Sperma_CUB_dom_sf
IPR036055LDL_receptor-like_sf
IPR028868NETO2
IPR000859CUB_dom
IPR002172LDrepeatLR_classA_rpt
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:2000312regulation of kainate selective glutamate receptor activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000859CUB domainSMARTSM00042CUB_2coord: 49..163
e-value: 3.1E-27
score: 106.5
IPR000859CUB domainPFAMPF00431CUBcoord: 55..160
e-value: 7.5E-26
score: 90.6
IPR000859CUB domainPROSITEPS01180CUBcoord: 39..163
score: 24.678
IPR000859CUB domainCDDcd00041CUBcoord: 49..162
e-value: 9.24094E-31
score: 114.047
IPR002172Low-density lipoprotein (LDL) receptor class A repeatSMARTSM00192LDLa_2coord: 305..341
e-value: 2.3E-4
score: 30.5
IPR002172Low-density lipoprotein (LDL) receptor class A repeatPFAMPF00057Ldl_recept_acoord: 304..337
e-value: 1.9E-5
score: 24.8
IPR002172Low-density lipoprotein (LDL) receptor class A repeatPROSITEPS50068LDLRA_2coord: 305..340
score: 10.125
IPR002172Low-density lipoprotein (LDL) receptor class A repeatCDDcd00112LDLacoord: 306..337
e-value: 1.53577E-6
score: 42.9642
IPR035914Spermadhesin, CUB domain superfamilyGENE3DG3DSA:2.60.120.290coord: 49..166
e-value: 3.2E-32
score: 113.2
IPR035914Spermadhesin, CUB domain superfamilySUPERFAMILYSSF49854Spermadhesin, CUB domaincoord: 56..162
IPR036055LDL receptor-like superfamilyGENE3DG3DSA:4.10.400.10coord: 300..370
e-value: 2.8E-7
score: 32.2
IPR036055LDL receptor-like superfamilySUPERFAMILYSSF57424LDL receptor-like modulecoord: 303..338
NoneNo IPR availablePANTHERPTHR45645FAMILY NOT NAMEDcoord: 59..403
NoneNo IPR availableTMHMMTMhelixcoord: 373..395
IPR028868Neuropilin and tolloid-like protein 2PANTHERPTHR45645:SF22NEUROPILIN AND TOLLOID-LIKE PROTEIN 2coord: 59..403