Serine protease

Overview
NameSerine protease
Smed IDSMED30034608
Length (bp)915
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Serine protease (SMED30034608) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine protease (SMED30034608) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine protease (SMED30034608) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine protease (SMED30034608) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034608

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30034608h1SMcG0004508 dd_Smed_v6_26553_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
neoblastSMED30034608h1SMcG0004508 SMED_14785_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034608h1SMcG0004508 SMED_14785_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Serine protease vs. Ensembl Human
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 114.39 bits (285), Expect = 1.501e-28
Identity = 72/195 (36.92%), Postives = 111/195 (56.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKIN-SGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +              ++ GSGF+  E G I+T AHV+ ++H   V + +G T++A +   D+  D+ALIKI+  GKL +  L     + ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+
Sbjct:   66 IADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPV--LLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFL 258
[Close]
BLAST of Serine protease vs. Ensembl Human
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 113.62 bits (283), Expect = 7.256e-28
Identity = 77/224 (34.38%), Postives = 122/224 (54.46%), Query Frame = 3 
Query:  162 HKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKIN-SGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            H+ PV  L+         + ++L    + + +VVE + P+VV +              ++ GSGF+  E G I+T AHV+ ++H   V + +G T++A +   D+  D+ALIKI+  GKL +  L     + ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+
Sbjct:  143 HRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPV--LLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFL 364
[Close]
BLAST of Serine protease vs. Ensembl Human
Match: HTRA4 (HtrA serine peptidase 4 [Source:HGNC Symbol;Acc:HGNC:26909])

HSP 1 Score: 108.997 bits (271), Expect = 4.156e-26
Identity = 81/224 (36.16%), Postives = 118/224 (52.68%), Query Frame = 3 
Query:  192 IKFANALTNESNLFKPLSR----LTEVVEIVQPSVVKVFNAGTEMSG--------GSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYF-DGIGGFAISSEYCTKFIKHINVH 815
            +++ N     +    PL R    +  VVE V PSVV V   G  + G        GSGF+  E G I+T AHV++++    V + +G  ++A V   D  +DLA+IKI S   +L  L     + ++ GE  +ALG+  S   +AT G+VS  +R G     K+  + Y+Q DA I  G SGGPLVNL G VIG++ +   DGI  FAI S+   +F+   + H
Sbjct:  147 VQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNA-ELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGI-SFAIPSDRVRQFLAEYHEH 368
[Close]
BLAST of Serine protease vs. Ensembl Human
Match: HTRA3 (HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406])

HSP 1 Score: 103.605 bits (257), Expect = 8.573e-25
Identity = 68/200 (34.00%), Postives = 108/200 (54.00%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +        F     +S GSGF+  E+G I+T AHV+             V++ +G++++A +   D   D+A IKI+  K KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+
Sbjct:  143 IADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKK-KLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFL 341
[Close]
BLAST of Serine protease vs. Ensembl Human
Match: HTRA3 (HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406])

HSP 1 Score: 104.375 bits (259), Expect = 1.308e-24
Identity = 68/200 (34.00%), Postives = 108/200 (54.00%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +        F     +S GSGF+  E+G I+T AHV+             V++ +G++++A +   D   D+A IKI+  K KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+
Sbjct:  143 IADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKK-KLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFL 341
[Close]
BLAST of Serine protease vs. Ensembl Fly
Match: HtrA2 (gene:FBgn0038233 transcript:FBtr0082987)

HSP 1 Score: 104.375 bits (259), Expect = 4.918e-25
Identity = 62/168 (36.90%), Postives = 97/168 (57.74%), Query Frame = 3 
Query:  315 SGGSGFVFDESGYILTCAHVIQDEHDTLV--RVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            S GSGF+ +++G ILT AHV+ ++  T+V  R+  G TF A +   D   DLA ++I    L +  ++    ++++ GE  +ALG+ L+ + + T GV+S T+R       +N  + Y+QTDA I  G SGGPLVNL G+ IG++ M       FAI  +Y   F++ 
Sbjct:  139 SNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSV--MRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLER 304
[Close]
BLAST of Serine protease vs. Ensembl Fly
Match: HtrA2 (gene:FBgn0038233 transcript:FBtr0330045)

HSP 1 Score: 104.375 bits (259), Expect = 4.918e-25
Identity = 62/168 (36.90%), Postives = 97/168 (57.74%), Query Frame = 3 
Query:  315 SGGSGFVFDESGYILTCAHVIQDEHDTLV--RVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            S GSGF+ +++G ILT AHV+ ++  T+V  R+  G TF A +   D   DLA ++I    L +  ++    ++++ GE  +ALG+ L+ + + T GV+S T+R       +N  + Y+QTDA I  G SGGPLVNL G+ IG++ M       FAI  +Y   F++ 
Sbjct:  139 SNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSV--MRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLER 304
[Close]
BLAST of Serine protease vs. Ensembl Zebrafish
Match: htra1b (HtrA serine peptidase 1b [Source:NCBI gene;Acc:565082])

HSP 1 Score: 120.553 bits (301), Expect = 1.570e-30
Identity = 74/195 (37.95%), Postives = 111/195 (56.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVV-------KVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            + +VVE + P+VV        VFN    ++ GSGFV  E G I+T AHV+ ++H   V + +G T+ A +   D+  D+ALIKI++  +KL  L       ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   +F+  
Sbjct:  169 IADVVEKIAPAVVHIELFRKNVFNREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKTGTTYDAKIKDVDEKADIALIKIDA-PMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAE 362
[Close]
BLAST of Serine protease vs. Ensembl Zebrafish
Match: htra3a (HtrA serine peptidase 3a [Source:ZFIN;Acc:ZDB-GENE-040801-245])

HSP 1 Score: 112.849 bits (281), Expect = 1.181e-27
Identity = 74/204 (36.27%), Postives = 110/204 (53.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHIN 809
            + +VVE + P+VV V        F     +S GSGF+  +SG I+T AHV+             V++H G+T++A +   D   D+A IKIN  K KL+ L       ++ GE  +A+G+  +   + T G+VS T+R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+   N
Sbjct:  155 IADVVEKIAPAVVHVELFLNHPLFGRHVPLSSGSGFIMTQSGLIVTNAHVVASSATVTGRQHLRVQLHDGQTYEASIRDIDKKSDIATIKINPKK-KLQVLSLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTTQRDGKELGIRDSDMGYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRINKFLDESN 357
[Close]
BLAST of Serine protease vs. Ensembl Zebrafish
Match: htra3a (HtrA serine peptidase 3a [Source:ZFIN;Acc:ZDB-GENE-040801-245])

HSP 1 Score: 112.849 bits (281), Expect = 1.181e-27
Identity = 74/204 (36.27%), Postives = 110/204 (53.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHIN 809
            + +VVE + P+VV V        F     +S GSGF+  +SG I+T AHV+             V++H G+T++A +   D   D+A IKIN  K KL+ L       ++ GE  +A+G+  +   + T G+VS T+R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+   N
Sbjct:  155 IADVVEKIAPAVVHVELFLNHPLFGRHVPLSSGSGFIMTQSGLIVTNAHVVASSATVTGRQHLRVQLHDGQTYEASIRDIDKKSDIATIKINPKK-KLQVLSLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTTQRDGKELGIRDSDMGYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRINKFLDESN 357
[Close]
BLAST of Serine protease vs. Ensembl Zebrafish
Match: htra3a (HtrA serine peptidase 3a [Source:ZFIN;Acc:ZDB-GENE-040801-245])

HSP 1 Score: 112.849 bits (281), Expect = 1.181e-27
Identity = 74/204 (36.27%), Postives = 110/204 (53.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHIN 809
            + +VVE + P+VV V        F     +S GSGF+  +SG I+T AHV+             V++H G+T++A +   D   D+A IKIN  K KL+ L       ++ GE  +A+G+  +   + T G+VS T+R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+   N
Sbjct:  155 IADVVEKIAPAVVHVELFLNHPLFGRHVPLSSGSGFIMTQSGLIVTNAHVVASSATVTGRQHLRVQLHDGQTYEASIRDIDKKSDIATIKINPKK-KLQVLSLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTTQRDGKELGIRDSDMGYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRINKFLDESN 357
[Close]
BLAST of Serine protease vs. Ensembl Zebrafish
Match: si:dkey-33c12.12 (si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-30])

HSP 1 Score: 107.071 bits (266), Expect = 8.347e-26
Identity = 76/209 (36.36%), Postives = 110/209 (52.63%), Query Frame = 3 
Query:  231 FKPLSR------LTEVVEIVQPSVVKVFNAG--------TEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSL---FAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            FKP S       + +VVE   P+VV +   G          +S GSGF+    G I+T AHV+ ++    V++ +GET+ A V   D   D+A IKIN  K  L +L+    + ++ GE  +A+G+  S   + T G+VS  +R GS     +  N+ YIQTDA I  G SGGPL+NL G+VIG++ M       FAI S+    F+  
Sbjct:  115 FKPDSPRYKYNFIADVVEKSTPAVVYIEIVGRHPFSGREVPISNGSGFIVSSDGLIVTNAHVVANKRGVRVKLTNGETYNATVQDVDQAADIATIKINV-KNPLPTLRLGKSSDVRQGEFVVAMGSPFSLKNTITSGIVSSAQR-GSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISFAIPSDRVRLFLDR 321
[Close]
BLAST of Serine protease vs. Ensembl Xenopus
Match: zic4 (Zic family member 4 [Source:Xenbase;Acc:XB-GENE-1033015])

HSP 1 Score: 103.605 bits (257), Expect = 8.023e-26
Identity = 68/168 (40.48%), Postives = 101/168 (60.12%), Query Frame = 3 
Query:  312 MSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSL--FAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCM-YFDGIGGFAISSEYCTKFIKH 803
            +S GSGF+    G I+T AHV+ +     V++ +GE+++A V   D   D+A IKIN  K+ L +L+      I+ GE  +A+G+  S   + T G+VS  +R G     A ++++YIQTDA I  G SGGPLVNL G+VIG++ M    GI  FAI S+   +F++H
Sbjct:    2 VSSGSGFLVSPDGLIVTNAHVVANRRRVRVKLSNGESYEAAVRDVDPATDIATIKINP-KVPLPTLRLGRSAEIRQGEFVVAMGSPFSLQNTITSGIVSSVQRGGHELGLANRDMEYIQTDAAIDFGNSGGPLVNLDGEVIGINTMKVVPGI-SFAIPSDRVREFLQH 167
[Close]
BLAST of Serine protease vs. Ensembl Xenopus
Match: mettl3 (methyltransferase like 3 [Source:Xenbase;Acc:XB-GENE-922807])

HSP 1 Score: 106.301 bits (264), Expect = 2.809e-25
Identity = 71/194 (36.60%), Postives = 108/194 (55.67%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVV--KVFN----AGTEM--SGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VV+ + P+VV  ++F      G EM  S GSGF+  + G I+T AHV+ ++    V V  G  + A +   D  +D+ALIKI+     L  L       ++ GE  +ALG+  S   + T G++S T+R G     K+  ++YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   +F+
Sbjct:  162 IADVVQKIAPAVVHLELFRRSPFTGQEMAVSSGSGFIVSDDGLIVTNAHVLTNKQRIKVEVKDGAHYDAKIKDIDQKLDIALIKIDP-DAPLPVLMLGRSADLRPGEFVVALGSPFSLQNTVTTGIISTTQRGGKELGLKDSDMEYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRIRQFL 354
[Close]
BLAST of Serine protease vs. Ensembl Xenopus
Match: psma1 (proteasome subunit alpha 1 [Source:Xenbase;Acc:XB-GENE-995831])

HSP 1 Score: 100.908 bits (250), Expect = 2.170e-23
Identity = 68/200 (34.00%), Postives = 108/200 (54.00%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDT------LVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +        F     +S GSGF+  + G I+T AHV+   +         V++H+G++++A +   D   D+A IKI   K KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + Y+QTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  TKF+
Sbjct:  151 IADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIISDLGLIVTNAHVVSSSNTVSGRQYLKVQLHNGDSYEATIKDIDKKSDIATIKIYPRK-KLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITKFM 349
[Close]
BLAST of Serine protease vs. Ensembl Xenopus
Match: htra1 (HtrA serine peptidase 1 [Source:NCBI gene;Acc:780187])

HSP 1 Score: 65.855 bits (159), Expect = 1.924e-11
Identity = 41/106 (38.68%), Postives = 58/106 (54.72%), Query Frame = 3 
Query:  495 KLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            KL  L       ++ GE  +A+G+  S   + T G+VS  +R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+  
Sbjct:  238 KLPVLLLGRSEDLRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRKFLAE 343
[Close]
BLAST of Serine protease vs. Ensembl Xenopus
Match: htra1 (HtrA serine peptidase 1 [Source:NCBI gene;Acc:780187])

HSP 1 Score: 65.4698 bits (158), Expect = 2.406e-11
Identity = 41/104 (39.42%), Postives = 58/104 (55.77%), Query Frame = 3 
Query:  495 KLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            KL  L       ++ GE  +A+G+  S   + T G+VS  +R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+
Sbjct:  197 KLPVLLLGRSEDLRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRKFL 300
[Close]
BLAST of Serine protease vs. Ensembl Mouse
Match: Htra4 (HtrA serine peptidase 4 [Source:MGI Symbol;Acc:MGI:3036260])

HSP 1 Score: 114.775 bits (286), Expect = 2.607e-28
Identity = 78/207 (37.68%), Postives = 109/207 (52.66%), Query Frame = 3 
Query:  213 TNESNLFKPLSRLTEVVEIVQPSVV--------KVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIK 800
            T    L +  + +  VVE V PSVV         + N     S GSGF+  E G I+T AHV+ ++    V + SG  ++A V   D  +DLALIKI     +L  L     + ++ GE  +ALG+  S   + T G+VS T+R G     KN  + YIQTDA+I  G SGGPLVNL G VIG++ +       FAI S+   +F++
Sbjct:  164 TRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEP-DTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLE 369
[Close]
BLAST of Serine protease vs. Ensembl Mouse
Match: Htra1 (HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI:1929076])

HSP 1 Score: 109.768 bits (273), Expect = 1.301e-26
Identity = 71/195 (36.41%), Postives = 111/195 (56.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKIN-SGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +              ++ GSGF+  E G I+T AHV+ +++   V + +G T++A +   D+  D+ALIKI+  GKL +  L     + ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+
Sbjct:  172 IADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPV--LLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFL 364
[Close]
BLAST of Serine protease vs. Ensembl Mouse
Match: Htra3 (HtrA serine peptidase 3 [Source:MGI Symbol;Acc:MGI:1925808])

HSP 1 Score: 99.3673 bits (246), Expect = 2.277e-23
Identity = 67/200 (33.50%), Postives = 106/200 (53.00%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +        F     +S GSGF+  E+G I+T AHV+             V++ +G+ ++A +   D   D+A I I+  K KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+
Sbjct:  149 IADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATIVIHPKK-KLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFL 347
[Close]
BLAST of Serine protease vs. Ensembl Mouse
Match: Htra3 (HtrA serine peptidase 3 [Source:MGI Symbol;Acc:MGI:1925808])

HSP 1 Score: 100.138 bits (248), Expect = 2.771e-23
Identity = 67/202 (33.17%), Postives = 106/202 (52.48%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            + +VVE + P+VV +        F     +S GSGF+  E+G I+T AHV+             V++ +G+ ++A +   D   D+A I I+  K KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+  
Sbjct:  149 IADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATIVIHPKK-KLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSE 349
[Close]
BLAST of Serine protease vs. Ensembl Mouse
Match: Htra2 (HtrA serine peptidase 2 [Source:MGI Symbol;Acc:MGI:1928676])

HSP 1 Score: 97.8265 bits (242), Expect = 1.577e-22
Identity = 72/194 (37.11%), Postives = 107/194 (55.15%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVV--KVFN----AGTE--MSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYK--NVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE   P+VV  ++ +    +G E  +S GSGFV    G I+T AHV+ D     VR+ SG+T++A V   D   D+A ++I + K  L +L       ++ GE  +A+G+  +   + T G+VS  +R          NV+YIQTDA I  G SGGPLVNL G+VIG++ M       FAI S+   +F+
Sbjct:  150 IADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQT-KEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFL 342
[Close]
BLAST of Serine protease vs. UniProt/SwissProt
Match: sp|A9JRB3|HTR1B_DANRE (Serine protease HTRA1B OS=Danio rerio OX=7955 GN=htra1b PE=2 SV=1)

HSP 1 Score: 120.553 bits (301), Expect = 1.185e-29
Identity = 74/195 (37.95%), Postives = 111/195 (56.92%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVV-------KVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            + +VVE + P+VV        VFN    ++ GSGFV  E G I+T AHV+ ++H   V + +G T+ A +   D+  D+ALIKI++  +KL  L       ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   +F+  
Sbjct:  169 IADVVEKIAPAVVHIELFRKNVFNREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKTGTTYDAKIKDVDEKADIALIKIDA-PMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAE 362
[Close]
BLAST of Serine protease vs. UniProt/SwissProt
Match: sp|P05676|Y938_SYNP6 (Uncharacterized serine protease syc0938_d OS=Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) OX=269084 GN=syc0938_d PE=3 SV=2)

HSP 1 Score: 115.161 bits (287), Expect = 4.828e-28
Identity = 72/201 (35.82%), Postives = 110/201 (54.73%), Query Frame = 3 
Query:  321 GSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAY--KNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIG---GFAI----SSEYCTKFIKHINV-HGYLSIIKTKFSRDPFIGRIPDRKPN 890
            GSGFV D +G I+T AHV+ +     V +  G  F   V   D   DLAL+++++   +L + +  + ++++VG+ A+A+GN L    + T+G+VS   R  S      K + +IQTDA+I PG SGGPLVN  G+VIG++       G   GFAI    + +  T+ +K+  V H YL +     S  P + R  +R PN
Sbjct:  125 GSGFVVDGNGLIMTNAHVVANADQVRVTLRDGREFTGRVRGADSVTDLALVEVDTKGERLPTARIGNSSNVEVGDWAIAIGNPLGLDNTVTLGIVSSLGRRSSAVGIPDKRLDFIQTDAVINPGNSGGPLVNSRGEVIGINTAIRQAPGAGIGFAIPVNTAKQIETQLLKNGKVSHSYLGV--QLLSLTPQMARDNNRDPN 323
[Close]
BLAST of Serine protease vs. UniProt/SwissProt
Match: sp|A4IHA1|HTRA1_XENTR (Serine protease HTRA1 OS=Xenopus tropicalis OX=8364 GN=htra1 PE=2 SV=2)

HSP 1 Score: 115.931 bits (289), Expect = 5.070e-28
Identity = 74/194 (38.14%), Postives = 106/194 (54.64%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +        F      + GSGF+  E G ILT AHV+ ++H   V    G T+ A +I  D+  D+ALIKI + K KL  L       ++ GE  +A+G+  S   + T G+VS  +R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   KF+
Sbjct:  151 IADVVEKIAPAVVHIELFRMLPFFKREVPAASGSGFIVSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQIIDVDEKADIALIKIKA-KGKLPVLLLGRSEDLRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRKFL 343
[Close]
BLAST of Serine protease vs. UniProt/SwissProt
Match: sp|A6YFB5|HTRA1_XENLA (Serine protease HTRA1 OS=Xenopus laevis OX=8355 GN=htra1 PE=1 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 7.047e-28
Identity = 73/196 (37.24%), Postives = 106/196 (54.08%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            + +VVE + P+VV +        F      + GSGF+  E G ILT AHV+ ++H   V    G T+ A +I  D+  D+ALIKI + K KL  L       ++ GE  +A+G+  S   + T G+VS  +R G     +N  + YIQTDA+I  G SGGPLVNL G+V+G++ +       FAI S+   KF+  
Sbjct:  151 IADVVEKIAPAVVHIELFRILPFFKREVPAASGSGFIVSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQIIDVDEKADIALIKIKA-KGKLPVLLLGRSEELRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVVGINTLKVTAGISFAIPSDKIRKFMAE 345
[Close]
BLAST of Serine protease vs. UniProt/SwissProt
Match: sp|A2RT60|HTRA4_MOUSE (Serine protease HTRA4 OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1)

HSP 1 Score: 114.775 bits (286), Expect = 1.823e-27
Identity = 78/207 (37.68%), Postives = 109/207 (52.66%), Query Frame = 3 
Query:  213 TNESNLFKPLSRLTEVVEIVQPSVV--------KVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIK 800
            T    L +  + +  VVE V PSVV         + N     S GSGF+  E G I+T AHV+ ++    V + SG  ++A V   D  +DLALIKI     +L  L     + ++ GE  +ALG+  S   + T G+VS T+R G     KN  + YIQTDA+I  G SGGPLVNL G VIG++ +       FAI S+   +F++
Sbjct:  164 TRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEP-DTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLE 369
[Close]
BLAST of Serine protease vs. TrEMBL
Match: A0A1S3H151 (serine protease HTRA1B OS=Lingula unguis OX=7574 GN=LOC106151169 PE=4 SV=2)

HSP 1 Score: 128.642 bits (322), Expect = 1.482e-30
Identity = 92/267 (34.46%), Postives = 135/267 (50.56%), Query Frame = 3 
Query:   87 KYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTE----MSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGN-YLSTTSATMGVVSGTERYGSL--FAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIG-GFAISSEYCTKFI-------KHINVHGYLSIIKTK 842
            +  KII P    G A      T      PVSE      A +  ++ N+      + +VVE V P+VV  F  G       SGGSGF+  E G ILT AHVI ++    +++  G T+   V      +DLA +KIN+ + KL +L+      ++ GE  +A+G+ +L   S T+G++S   R G      + ++ Y+QTDA I PG SGGPLVNL GKV+G+S M       GFAI ++Y  +F+       K +   G  S+  +K
Sbjct:   42 RKNKIIAPKWAVGLATLGLSATLLLKYLPVSE------AKSKADDFNV------IADVVEEVLPAVV--FIEGNRSIFGRSGGSGFIIHEDGVILTNAHVIDNQQIIQIKLQDGTTYSGKVQYISHELDLATVKINA-RHKLPTLELAESRKVRAGEWVIAMGSPFLLNNSVTVGIISAVNRSGKDLGLGFSDMDYLQTDAAINPGNSGGPLVNLDGKVVGVSRMKLAMASIGFAIPADYVKEFLTKAENAEKQVKSKGTFSMFDSK 293
[Close]
BLAST of Serine protease vs. TrEMBL
Match: A0A2K9AL29 (Periplasmic serine endoprotease DegP-like OS=Kangiella profundi OX=1561924 GN=CW740_03415 PE=3 SV=1)

HSP 1 Score: 125.946 bits (315), Expect = 2.219e-29
Identity = 76/175 (43.43%), Postives = 103/175 (58.86%), Query Frame = 3 
Query:  252 TEVVEIVQPSVVKV------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTER--YGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFD 749
            TE+VE VQPS+V +      +      +GGSGF+ D+ GYILT  HVI +     V++++G  FKA VI  D   D+AL+KI  GK  LK+LK  +   +KVGE  LA G   +   + T G+VS   R   GS +    V +IQTD  I  G SGGPLVNL G+V+G++ M F+
Sbjct:   34 TELVEKVQPSIVSIQVDVIRWGRVAGRAGGSGFIIDDEGYILTNHHVIDNGDTVTVKLYNGREFKAEVIGSDANTDVALLKIEPGKQDLKALKLGTSDVLKVGEWVLAFGAPFNLEQTVTAGIVSAKGRGEVGSQY----VPFIQTDVAINRGNSGGPLVNLEGEVVGINSMVFN 204
[Close]
BLAST of Serine protease vs. TrEMBL
Match: A0A136JUC3 (PDZ domain-containing protein OS=Acidobacteria bacterium OLB17 OX=1617423 GN=UZ17_ACD001002109 PE=4 SV=1)

HSP 1 Score: 126.716 bits (317), Expect = 2.729e-29
Identity = 78/195 (40.00%), Postives = 113/195 (57.95%), Query Frame = 3 
Query:  321 GSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTER--YGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMY------FDGIGGFAISSEYCTKFIKHINVHG---------YLSIIKTKFSR 851
            GSGF+ D+SGYILT  HVI D     V++ +GE F A ++  DD  DLA++KIN+G+  L + +F     +KVG+  LA+G+      S + G++S TER   GS  A++  ++IQTDA+I PG SGGPLVN+ G+VIG++         F G+ GFA+ S    +    I   G         YL  IK +F++
Sbjct:   88 GSGFIVDKSGYILTNNHVITDSSRLTVKLETGEEFTAQIVGVDDETDLAVLKINAGR-DLPTARFGDSAKMKVGDWVLAIGSPFGLVKSVSAGIISQTERDTPGS-SAFQ--RFIQTDAVINPGNSGGPLVNMQGEVIGVNSQIATQTGEFSGV-GFALPSREAERVYSQIVASGKVSRGYLGAYLDSIKPEFAK 277
[Close]
BLAST of Serine protease vs. TrEMBL
Match: A0A101IDJ8 (Protease Do OS=Thermotogales bacterium 46_20 OX=1635293 GN=XE05_1076 PE=4 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 7.194e-29
Identity = 74/172 (43.02%), Postives = 106/172 (61.63%), Query Frame = 3 
Query:  321 GSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERY-----GSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGM-SCMYFDGIG---GFAISSEYCTKFIKHI 806
            GSGF+FDE GYI+T  HV+Q+     V +  G T+ A  I  D  +DLA+IKIN+   KL ++K  S + +++GE A+A+GN L    + T+GVVS  ER      GS + Y N+  IQTDA I PG SGGPL+N+HG+VIG+ + +    +G   GFAI  +   +F+  +
Sbjct:   76 GSGFIFDEEGYIMTNDHVVQNATRIQVTLLDGSTYPAEYIGGDRELDLAVIKINAEDKKLPTIKIGSSSMLRIGEWAIAIGNPLGFQQTVTVGVVSAVERQIPKPDGSGY-YSNL--IQTDAAINPGNSGGPLLNIHGEVIGINTALVAPQVGTALGFAIPIDVAMRFVDAL 244
[Close]
BLAST of Serine protease vs. TrEMBL
Match: A0A3B8N963 (Serine protease OS=Kosmotogaceae bacterium OX=2053567 GN=DCE14_01215 PE=4 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 7.194e-29
Identity = 74/172 (43.02%), Postives = 106/172 (61.63%), Query Frame = 3 
Query:  321 GSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERY-----GSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGM-SCMYFDGIG---GFAISSEYCTKFIKHI 806
            GSGF+FDE GYI+T  HV+Q+     V +  G T+ A  I  D  +DLA+IKIN+   KL ++K  S + +++GE A+A+GN L    + T+GVVS  ER      GS + Y N+  IQTDA I PG SGGPL+N+HG+VIG+ + +    +G   GFAI  +   +F+  +
Sbjct:   76 GSGFIFDEEGYIMTNDHVVQNATRIQVTLLDGSTYPAEYIGGDRELDLAVIKINAEDKKLPTIKIGSSSMLRIGEWAIAIGNPLGFQQTVTVGVVSAVERQIPKPDGSGY-YSNL--IQTDAAINPGNSGGPLLNIHGEVIGINTALVAPQVGTALGFAIPIDVAMRFVDAL 244
[Close]
BLAST of Serine protease vs. Ensembl Cavefish
Match: si:dkey-33c12.12 (serine protease HTRA2, mitochondrial [Source:NCBI gene;Acc:103043568])

HSP 1 Score: 115.546 bits (288), Expect = 7.660e-29
Identity = 86/251 (34.26%), Postives = 127/251 (50.60%), Query Frame = 3 
Query:  117 MGGTAFYCF----QKTFSNHKFPV------SELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEM--------SGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSL---FAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            + G A   F    +K      FP+      S L + + A+    +S  FK  + + +VVE   P+VV +   G  M        S GSGF+    G I+T AHV+ ++ D  V++ SGET+ A V   D   D+A IKI   K  L +L+    + ++ GE  +A+G+  +   + T G+VS T+R GS     +  N+ YIQTDA I  G SGGPL+NL G+VIG++ M       FAI S+    F+  
Sbjct:   83 LSGAALLSFKDEQEKDILQRIFPLRNSGLHSVLPVARCASPFKPDSPRFK-YNFIADVVEKSTPAVVYIEIVGRHMFSGRDVAVSNGSGFIVSSDGLIVTNAHVVANKRDVRVKLTSGETYNAVVQDVDQAADIATIKIQP-KHPLPTLRLAQSSEVRQGEFVVAMGSPFALRNTITSGIVSSTQR-GSKELGLSNPNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISFAIPSDRVRVFLNQ 330
[Close]
BLAST of Serine protease vs. Ensembl Cavefish
Match: htra1b (serine protease HTRA1B-like [Source:NCBI gene;Acc:103041103])

HSP 1 Score: 114.005 bits (284), Expect = 2.858e-28
Identity = 71/194 (36.60%), Postives = 109/194 (56.19%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV +              ++ GSGF+  E G I+T AHV+ ++H   V + SG T+ A +   D+  D+ALIKI++  +KL  L       ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   +F+
Sbjct:  163 IADVVEKIAPAVVHIELYRKMVFSKREVAVASGSGFIVSEDGLIVTNAHVVANKHRVKVELKSGATYDAKIKDVDEKADIALIKIDA-PMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFL 355
[Close]
BLAST of Serine protease vs. Ensembl Cavefish
Match: htra1a (serine protease HTRA1A [Source:NCBI gene;Acc:103042183])

HSP 1 Score: 112.079 bits (279), Expect = 1.466e-27
Identity = 78/225 (34.67%), Postives = 124/225 (55.11%), Query Frame = 3 
Query:  162 HKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVV------KVFNAGTEMS--GGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
             + PV  ++      AL + ++L    + + +VVE + P+VV      K+  +  EM+   GSGFV  + G I+T AHV+ +++   V + +G ++ A +   D+  D+ALIKI+S   KL  L       ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+  
Sbjct:  144 QQPPVLLIQRGACGTALEHPNSLRYKYNFIADVVEKIAPAVVHIELYRKMVYSKREMAVASGSGFVVSDDGLIVTNAHVVANKNRVKVELKNGASYDAKIKDVDEKSDIALIKIDSPS-KLSVLSLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKITQFLSE 367
[Close]
BLAST of Serine protease vs. Ensembl Cavefish
Match: HTRA3 (HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406])

HSP 1 Score: 108.612 bits (270), Expect = 2.220e-26
Identity = 76/216 (35.19%), Postives = 114/216 (52.78%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHINVHGYLSIIKTKF 845
            + +VVE + P+VV V        F     +S GSGFV  E+G I+T AHV+             V++H G  ++A +   D   D+A IKIN+ K KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+   +  G  S +K +F
Sbjct:  146 IADVVEKIAPAVVHVELFLSHPLFGRTVPLSSGSGFVMSETGLIVTNAHVVSSTTAVSGRQQLKVQMHDGNVYEATIKDIDKKSDIATIKINTQK-KLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGIQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLN--DSMGKQSKVKKRF 358
[Close]
BLAST of Serine protease vs. Ensembl Cavefish
Match: htra4 (serine protease HTRA1-like [Source:NCBI gene;Acc:103028201])

HSP 1 Score: 103.219 bits (256), Expect = 2.639e-24
Identity = 67/196 (34.18%), Postives = 109/196 (55.61%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV----------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VV+ + P+VV +           +    +S GSGF+  E G+I+T AHV+ ++    V +++G  + A     D  +D+ALIKI+S +  L  L     + ++ GE  +A+G+  S   + T G++S T+R G     +N  ++YIQTDA+I  G SGGPLVNL G VIG++ +       FAI S+   +F+
Sbjct:  179 IADVVDKIAPAVVHLELFRRLPYGDRDQEVPVSSGSGFIVSEDGWIVTNAHVLSNKQRIKVELNNGVHYDATAKDVDQKLDIALIKIDSEE-PLPVLLLGRSSDLRPGEFVVAVGSPFSLQNTVTTGIISTTQRGGHELGLQNSDMEYIQTDAIINYGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIQQFL 373
[Close]
BLAST of Serine protease vs. Ensembl Sea Lamprey
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 98.9821 bits (245), Expect = 1.866e-24
Identity = 67/208 (32.21%), Postives = 112/208 (53.85%), Query Frame = 3 
Query:  216 NESNLFKPLSRLTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTL---VRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKNVK--YIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            N  ++ + L+ +  V E  + +VV V        F+    +S GSGF+  E G ILT AHV+  + D +   V++ +G+T++A  +  D   ++A+IKIN+ K KL  L+      ++ GE  +A+G+      + T G+VS  +R G      +    YIQTDA++  G +GGPLVNL G+V+G++ +       FAI S+   + +
Sbjct:   92 NPDSVRERLNFIANVTERARRAVVHVELLARHLLFDRNVSVSSGSGFLVSEDGLILTNAHVVTHKRDLVAVKVQLTNGDTYEAWPLHVDMHANIAVIKINA-KQKLPVLRLARSAELRPGEFVVAIGSPFKLQNTVTTGIVSTAQRGGQELGLDDSDHDYIQTDAMVNYGSAGGPLVNLDGEVVGINTLKVTAGISFAIPSDRIRELL 298
[Close]
BLAST of Serine protease vs. Ensembl Sea Lamprey
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 95.9005 bits (237), Expect = 2.369e-24
Identity = 59/175 (33.71%), Postives = 94/175 (53.71%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV-------------------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGN-YLSTTSATMGVVSGTERYGSLFAYK--NVKYIQTDALIQPGFSGGPLVN 707
            + +VVE + P+VV +                   FN    ++ GSGF+  E G I+T AHV+ ++    V++H GE+++A V+  D+  D+A I+I + K KL  L+      ++ GE  +A+G+ +    + T G+VS  +R G     +  +  YIQTDA+I  G SGGPLVN
Sbjct:    3 IADVVEKIVPAVVHIELYSRSLSRQSSYAARHPFFNRNISVASGSGFMVSEDGVIVTNAHVVVNKRYVKVQLHDGESYEASVVDADEKADIATIRIKA-KQKLPVLRLARSAELRPGEFVVAIGSPFKLQNTVTTGIVSTAQRGGQELGLEDSDADYIQTDAIINYGNSGGPLVN 176
[Close]
BLAST of Serine protease vs. Ensembl Sea Lamprey
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 93.5893 bits (231), Expect = 2.544e-23
Identity = 59/183 (32.24%), Postives = 94/183 (51.37%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINS------------------GKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYK--NVKYIQTDALIQPGFSGGPLVNL 710
            + +VVE + P+VV +        FN    ++ GSGF+  E G I+T AHV+ ++    V++H GE+++A V+  D+  D+A I+I +                   + KL  L+      ++ GE  +A+G+      + T G+VS  +R G     +  +  YIQTDA+I  G SGGPLVNL
Sbjct:   12 IADVVEKIVPAVVHIELYSRHPFFNRNISVASGSGFMVSEDGVIVTNAHVVVNKRYVKVQLHDGESYEASVVDADEKADIATIRIKAKVTCRLRSSADVAAAPLPSQQKLPVLRLARSAELRPGEFVVAIGSPFKLQNTVTTGIVSTAQRGGQELGLEDSDADYIQTDAIINYGNSGGPLVNL 194
[Close]
BLAST of Serine protease vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002935.1 (pep scaffold:Pmarinus_7.0:GL478486:180388:188108:-1 gene:ENSPMAG00000002674.1 transcript:ENSPMAT00000002935.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.9214 bits (141), Expect = 7.729e-11
Identity = 47/168 (27.98%), Postives = 79/168 (47.02%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDT---LVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVK---YIQTDALIQPGFSGGPLVNL 710
            + +VV+   P+VV +        +     +S GSGF+  + G I+T AHV+     T   +V +  G +++A V   D  +D+A I+I+  +  L  L+    + ++ GE  +A+G+  +  +     +S  +R G      N K   Y         G SGGPLVNL
Sbjct:   18 IADVVQRAAPAVVHIEIFKSPPSYARAAPVSSGSGFLVSDEGLIVTNAHVVGGGGATRVVMVTLRGGRSYEAEVTDVDTKVDIATIRIHP-QHPLAVLQLGRSSELRPGEFVVAIGSPFALQNTVTTGMSTAQRGGRELGLHNSKRDTYWIAKHTKHYGNSGGPLVNL 184
[Close]
BLAST of Serine protease vs. Ensembl Medaka
Match: htra1b (HtrA serine peptidase 1 [Source:NCBI gene;Acc:101160199])

HSP 1 Score: 113.235 bits (282), Expect = 4.947e-28
Identity = 75/194 (38.66%), Postives = 111/194 (57.22%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVV------KVFNAGTEMS--GGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + P+VV      K+  +  E+S   GSGFV  E G I+T AHV+ ++H   V + SG T+ A +   D+  D+ALIKI++   KL  L       ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   +F+
Sbjct:  168 IADVVEKIAPAVVHIELFRKMVFSKREVSVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKSGATYDAKIKDIDEKADIALIKIDTPN-KLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKILQFL 360
[Close]
BLAST of Serine protease vs. Ensembl Medaka
Match: htra1a (serine protease HTRA1A [Source:NCBI gene;Acc:105355810])

HSP 1 Score: 112.849 bits (281), Expect = 8.978e-28
Identity = 73/194 (37.63%), Postives = 112/194 (57.73%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVV--KVFNAGT------EMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFI 797
            + +VVE + PSVV  ++F   T       ++ GSGFV  E G I+T AHV+ ++H   V + +G ++ A +   D+  D+ALIKI++   KL  L     + ++ GE  +A+G+  S   + T G+VS T+R G     +N  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+   +F+
Sbjct:  168 IADVVEKIAPSVVHIELFRKMTYSKREVAVASGSGFVVSEDGQIVTNAHVVANKHRVKVELKNGASYDAKIKDVDEKADIALIKIDA-PTKLPVLLLGHSSDLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFL 360
[Close]
BLAST of Serine protease vs. Ensembl Medaka
Match: HTRA3 (HtrA serine peptidase 3 [Source:NCBI gene;Acc:101162823])

HSP 1 Score: 104.76 bits (260), Expect = 6.421e-25
Identity = 75/218 (34.40%), Postives = 117/218 (53.67%), Query Frame = 3 
Query:  249 LTEVVEIVQPSVVKV--------FNAGTEMSGGSGFVFDESGYILTCAHVIQD------EHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKN--VKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH-INVHG-YLSIIKTKF 845
            + +VVE + P+VV +              +S GSGFV  E+G I+T AHV+        +    V++H+G+ ++A +   D   D+A IKIN  ++KL  L       ++ GE  +A+G+  +   + T G+VS  +R G     ++  + YIQTDA+I  G SGGPLVNL G+VIG++ +       FAI S+  T+F+   +N H   L  IK +F
Sbjct:  154 IADVVEKIAPAVVHIELFLRHPLLGRNIALSSGSGFVMTENGLIVTNAHVVSSSSPVSGQQHLKVQMHNGDVYEATIKDIDKKSDIATIKINP-QIKLPVLFLGQSADLRPGEFVVAIGSPFALQNTVTTGIVSSAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLNDSLNKHSKELRPIKKRF 370
[Close]
BLAST of Serine protease vs. Ensembl Medaka
Match: si:dkey-33c12.12 (serine protease HTRA2, mitochondrial-like [Source:NCBI gene;Acc:101174474])

HSP 1 Score: 100.523 bits (249), Expect = 1.271e-23
Identity = 72/208 (34.62%), Postives = 108/208 (51.92%), Query Frame = 3 
Query:  231 FKPLSR------LTEVVEIVQPSVVKVFNAG--------TEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLF--AYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKH 803
            FKP S       + +VVE   P+VV +   G          +S GSGF+    G I+T AHV+ ++    V++ +G+ + A V   D   D+A IKI + K  L +LK    + I+ GE  +A+G+  +   + T G+VS  +R       +  N++YIQTDA I  G SGGPL+NL G+VIG++ M       FAI S+    F+  
Sbjct:  115 FKPDSPRFKYNFIADVVEKSTPAVVYIEILGRHPFSGREVPVSNGSGFIISSDGLIVTNAHVVANKRGVRVKLTNGDMYHASVQDVDPVADIATIKITT-KNPLPTLKLGQSSDIRQGEFVVAMGSPFALRNTITSGIVSSAQRDSKELGLSNPNMEYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISFAIPSDRLKIFLDQ 321
[Close]
BLAST of Serine protease vs. Planmine SMEST
Match: SMESG000006683.1 (SMESG000006683.1)

HSP 1 Score: 555.829 bits (1431), Expect = 0.000e+0
Identity = 271/271 (100.00%), Postives = 271/271 (100.00%), Query Frame = 3 
Query:   78 MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHINVHGYLSIIKTKFSRDPFIGRIPDRKPN 890
            MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHINVHGYLSIIKTKFSRDPFIGRIPDRKPN
Sbjct:    1 MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHINVHGYLSIIKTKFSRDPFIGRIPDRKPN 271
[Close]
BLAST of Serine protease vs. Planmine SMEST
Match: SMESG000006683.1 (SMESG000006683.1)

HSP 1 Score: 407.912 bits (1047), Expect = 1.365e-145
Identity = 200/200 (100.00%), Postives = 200/200 (100.00%), Query Frame = 3 
Query:   78 MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ 677
            MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ
Sbjct:    1 MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ 200
[Close]
BLAST of Serine protease vs. Planmine SMEST
Match: SMESG000006683.1 (SMESG000006683.1)

HSP 1 Score: 380.948 bits (977), Expect = 4.306e-135
Identity = 187/187 (100.00%), Postives = 187/187 (100.00%), Query Frame = 3 
Query:  117 MGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ 677
            MGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ
Sbjct:    1 MGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ 187
[Close]
BLAST of Serine protease vs. Planmine SMEST
Match: SMESG000006679.1 (SMESG000006679.1)

HSP 1 Score: 159.073 bits (401), Expect = 6.511e-46
Identity = 92/232 (39.66%), Postives = 140/232 (60.34%), Query Frame = 3 
Query:  114 LMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEM--SGGSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIK 800
            +  G ++Y  +    N+    S L  +  ANA T+  +     + + +VVE + PSVV +   G+ +  S GSGF+ ++SGYILT AHV+       V +  G+ F+  VI  D   DLAL+K+N GK+KL+SL+F   + ++ GE  +ALG+ ++ + S T+GVVS  +R   L   K ++Y+QTDA+I  G SGGPLVNL+G+VIG++ M      GFAI S +C +F+K
Sbjct:    1 MTSGVSYYISKNRKLNN-VSTSSLTSLITANAATSRQDQINSFNFIADVVETITPSVVSITVGGSLLGVSFGSGFIVEDSGYILTNAHVVARNPYVSVTLSDGQKFQGEVIAMDRSSDLALVKVNPGKIKLQSLRFAEISKLRAGEFVIALGSPMTLSNSVTVGVVSAVQR--DLGHSKGLRYVQTDAIITVGNSGGPLVNLYGEVIGVNTMMVSTGFGFAIPSNHCNQFVK 229
[Close]
BLAST of Serine protease vs. Planmine SMEST
Match: SMESG000006679.1 (SMESG000006679.1)

HSP 1 Score: 157.532 bits (397), Expect = 2.868e-45
Identity = 91/233 (39.06%), Postives = 137/233 (58.80%), Query Frame = 3 
Query:  114 LMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESNLFKPLSRLTEVVEIVQPSVVKVFNAGTEMSG---GSGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHTSIKVGELALALGNYLS-TTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQPGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIK 800
            +  G ++Y   K    +    S L  +  ANA T+  +     + + +VVE + PSVV +      + G   GSGF+ ++SGYILT AHV+       V +  G+ F+  VI  D   DLAL+K+N GK+KL+SL+F   + ++ GE  +ALG+ ++ + S T+GVVS  +R   L   K ++Y+QTDA+I  G SGGPLVNL+G+VIG++ M      GFAI S +C +F+K
Sbjct:    1 MTSGVSYY-ISKNRKLNNVSTSSLTSLITANAATSRQDQINSFNFIADVVETITPSVVSITVGSGSLLGVSFGSGFIVEDSGYILTNAHVVARNPYVSVTLSDGQKFQGEVIAMDRSSDLALVKVNPGKIKLQSLRFAEISKLRAGEFVIALGSPMTLSNSVTVGVVSAVQR--DLGHSKGLRYVQTDAIITVGNSGGPLVNLYGEVIGVNTMMVSTGFGFAIPSNHCNQFVK 230
The following BLAST results are available for this feature:
BLAST of Serine protease vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HTRA11.501e-2836.92HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
HTRA17.256e-2834.38HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
HTRA44.156e-2636.16HtrA serine peptidase 4 [Source:HGNC Symbol;Acc:HG... [more]
HTRA38.573e-2534.00HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HG... [more]
HTRA31.308e-2434.00HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of Serine protease vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Serine protease vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
HtrA24.918e-2536.90gene:FBgn0038233 transcript:FBtr0082987[more]
HtrA24.918e-2536.90gene:FBgn0038233 transcript:FBtr0330045[more]
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BLAST of Serine protease vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
htra1b1.570e-3037.95HtrA serine peptidase 1b [Source:NCBI gene;Acc:565... [more]
htra3a1.181e-2736.27HtrA serine peptidase 3a [Source:ZFIN;Acc:ZDB-GENE... [more]
htra3a1.181e-2736.27HtrA serine peptidase 3a [Source:ZFIN;Acc:ZDB-GENE... [more]
htra3a1.181e-2736.27HtrA serine peptidase 3a [Source:ZFIN;Acc:ZDB-GENE... [more]
si:dkey-33c12.128.347e-2636.36si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-... [more]
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BLAST of Serine protease vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
zic48.023e-2640.48Zic family member 4 [Source:Xenbase;Acc:XB-GENE-10... [more]
mettl32.809e-2536.60methyltransferase like 3 [Source:Xenbase;Acc:XB-GE... [more]
psma12.170e-2334.00proteasome subunit alpha 1 [Source:Xenbase;Acc:XB-... [more]
htra11.924e-1138.68HtrA serine peptidase 1 [Source:NCBI gene;Acc:7801... [more]
htra12.406e-1139.42HtrA serine peptidase 1 [Source:NCBI gene;Acc:7801... [more]
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BLAST of Serine protease vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Htra42.607e-2837.68HtrA serine peptidase 4 [Source:MGI Symbol;Acc:MGI... [more]
Htra11.301e-2636.41HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI... [more]
Htra32.277e-2333.50HtrA serine peptidase 3 [Source:MGI Symbol;Acc:MGI... [more]
Htra32.771e-2333.17HtrA serine peptidase 3 [Source:MGI Symbol;Acc:MGI... [more]
Htra21.577e-2237.11HtrA serine peptidase 2 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of Serine protease vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A9JRB3|HTR1B_DANRE1.185e-2937.95Serine protease HTRA1B OS=Danio rerio OX=7955 GN=h... [more]
sp|P05676|Y938_SYNP64.828e-2835.82Uncharacterized serine protease syc0938_d OS=Synec... [more]
sp|A4IHA1|HTRA1_XENTR5.070e-2838.14Serine protease HTRA1 OS=Xenopus tropicalis OX=836... [more]
sp|A6YFB5|HTRA1_XENLA7.047e-2837.24Serine protease HTRA1 OS=Xenopus laevis OX=8355 GN... [more]
sp|A2RT60|HTRA4_MOUSE1.823e-2737.68Serine protease HTRA4 OS=Mus musculus OX=10090 GN=... [more]
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BLAST of Serine protease vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3H1511.482e-3034.46serine protease HTRA1B OS=Lingula unguis OX=7574 G... [more]
A0A2K9AL292.219e-2943.43Periplasmic serine endoprotease DegP-like OS=Kangi... [more]
A0A136JUC32.729e-2940.00PDZ domain-containing protein OS=Acidobacteria bac... [more]
A0A101IDJ87.194e-2943.02Protease Do OS=Thermotogales bacterium 46_20 OX=16... [more]
A0A3B8N9637.194e-2943.02Serine protease OS=Kosmotogaceae bacterium OX=2053... [more]
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BLAST of Serine protease vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-33c12.127.660e-2934.26serine protease HTRA2, mitochondrial [Source:NCBI ... [more]
htra1b2.858e-2836.60serine protease HTRA1B-like [Source:NCBI gene;Acc:... [more]
htra1a1.466e-2734.67serine protease HTRA1A [Source:NCBI gene;Acc:10304... [more]
HTRA32.220e-2635.19HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HG... [more]
htra42.639e-2434.18serine protease HTRA1-like [Source:NCBI gene;Acc:1... [more]
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BLAST of Serine protease vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
HTRA11.866e-2432.21HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
HTRA12.369e-2433.71HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
HTRA12.544e-2332.24HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
ENSPMAT00000002935.17.729e-1127.98pep scaffold:Pmarinus_7.0:GL478486:180388:188108:-... [more]
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BLAST of Serine protease vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Serine protease vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Serine protease vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
htra1b4.947e-2838.66HtrA serine peptidase 1 [Source:NCBI gene;Acc:1011... [more]
htra1a8.978e-2837.63serine protease HTRA1A [Source:NCBI gene;Acc:10535... [more]
HTRA36.421e-2534.40HtrA serine peptidase 3 [Source:NCBI gene;Acc:1011... [more]
si:dkey-33c12.121.271e-2334.62serine protease HTRA2, mitochondrial-like [Source:... [more]
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BLAST of Serine protease vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000006683.10.000e+0100.00SMESG000006683.1[more]
SMESG000006683.11.365e-145100.00SMESG000006683.1[more]
SMESG000006683.14.306e-135100.00SMESG000006683.1[more]
SMESG000006679.16.511e-4639.66SMESG000006679.1[more]
SMESG000006679.12.868e-4539.06SMESG000006679.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034608 ID=SMED30034608|Name=Serine protease|organism=Schmidtea mediterranea sexual|type=transcript|length=915bp
TTTACATTTAAATTTATGAGATTAATTTAATGAATTTAATCTACTTGTTT
ATCTGAATTAGGTTTCATTATTAAATTATGTTAAGAAAATATCAAAAAAT
TATCTTACCGATTTTAATGGGTGGAACAGCTTTTTACTGTTTCCAGAAAA
CATTTTCAAATCATAAATTTCCAGTCTCAGAGTTGAAAATAATTAAATTT
GCAAATGCCTTGACAAATGAATCGAATTTGTTTAAGCCGCTCTCTCGGTT
GACTGAAGTTGTAGAAATCGTTCAACCAAGTGTTGTCAAAGTTTTCAACG
CCGGCACCGAAATGTCCGGAGGTTCGGGCTTCGTGTTTGATGAATCCGGA
TATATTTTGACATGTGCTCATGTTATTCAAGATGAACATGACACCTTAGT
TAGGGTTCACAGCGGTGAAACATTTAAAGCTCATGTTATTATGAAGGATG
ACCCAATGGATTTAGCTTTAATCAAAATAAACTCTGGAAAATTAAAACTA
AAATCTTTGAAATTTGAGAGTCATACTTCAATTAAAGTCGGTGAGCTAGC
ACTTGCTCTGGGAAACTATTTGTCAACAACCTCTGCAACAATGGGAGTTG
TCTCTGGAACCGAGCGTTATGGTAGCCTTTTTGCTTATAAAAATGTAAAA
TATATACAAACAGATGCTTTAATACAACCAGGATTTTCAGGTGGCCCATT
AGTAAATTTGCATGGCAAAGTCATAGGAATGTCTTGTATGTATTTCGATG
GCATTGGGGGATTTGCTATATCCAGTGAATATTGTACGAAATTTATCAAG
CATATAAATGTTCATGGCTATTTGTCAATAATAAAAACTAAATTTTCAAG
AGACCCTTTCATCGGTAGAATTCCAGATAGAAAACCAAACTGATTATAAT
AATTGTTTATCGTGT
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protein sequence of SMED30034608-orf-1

>SMED30034608-orf-1 ID=SMED30034608-orf-1|Name=SMED30034608-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=272bp
MLRKYQKIILPILMGGTAFYCFQKTFSNHKFPVSELKIIKFANALTNESN
LFKPLSRLTEVVEIVQPSVVKVFNAGTEMSGGSGFVFDESGYILTCAHVI
QDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKINSGKLKLKSLKFESHT
SIKVGELALALGNYLSTTSATMGVVSGTERYGSLFAYKNVKYIQTDALIQ
PGFSGGPLVNLHGKVIGMSCMYFDGIGGFAISSEYCTKFIKHINVHGYLS
IIKTKFSRDPFIGRIPDRKPN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000420parapharyngeal region
PLANA:0000429neoblast
Vocabulary: INTERPRO
TermDefinition
IPR001940Peptidase_S1C
IPR009003Peptidase_S1_PA
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
Vocabulary: molecular function
TermDefinition
GO:0004252serine-type endopeptidase activity
GO:0008233peptidase activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001940Peptidase S1CPRINTSPR00834PROTEASES2Ccoord: 211..228
score: 30.62
coord: 112..132
score: 32.75
coord: 189..206
score: 56.1
coord: 91..103
score: 48.41
coord: 154..178
score: 22.34
NoneNo IPR availableGENE3DG3DSA:2.40.10.120coord: 48..246
e-value: 3.7E-49
score: 169.0
NoneNo IPR availablePFAMPF13365Trypsin_2coord: 82..218
e-value: 9.4E-26
score: 91.5
NoneNo IPR availablePANTHERPTHR22939SERINE PROTEASE FAMILY S1C HTRA-RELATEDcoord: 33..247
IPR009003Peptidase S1, PA clanSUPERFAMILYSSF50494Trypsin-like serine proteasescoord: 57..245