TNF receptor-associated factor

Overview
NameTNF receptor-associated factor
Smed IDSMED30034560
Length (bp)1591
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TNF receptor-associated factor (SMED30034560) t-SNE clustered cells

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30034560) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor-associated factor (SMED30034560) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30034560) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034560

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30034560SMESG000012042.1 Contig4200GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30034560SMESG000020135.1 Contig4200GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30034560SMESG000020135.1 dd_Smed_v4_974_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30034560SMESG000020135.1 dd_Smed_v4_974_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30034560SMESG000020135.1 dd_Smed_v4_974_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30034560SMESG000020135.1 Contig39430newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30034560SMESG000020135.1 Contig39430uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF4 (TNF receptor associated factor 4 [Source:HGNC Symbol;Acc:HGNC:12034])

HSP 1 Score: 116.316 bits (290), Expect = 2.845e-27
Identity = 107/481 (22.25%), Postives = 197/481 (40.96%), Query Frame = 2 
Query:  125 MENYDFSGVE-VDSDMICGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEI----------------------KIIVGNFKGQFDKNTNDQSYWAE--IESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M  +D+  +E     ++C LCGK M      + CG RFC  C+  +L+     CP  +D   L+       I  D  +  ++  L I+C   E  C +   LR ++ H++ C+   I CP      N   + L +  +P HL++D          C  + + E  E                       +++  +   +  K T   +Y  +  +   +Q    +   L     N   +  V R     E L   + D+           +    +     A++  +++++K  L  +  + V+ +R +  E                +WK+  +  +++ AK    L  FS +FYTH+YGYK+ +  F NGN      +LS+++ ++    D++LEWPF    TFSL++Q      +  H   T      + NFQ        + E ++G+GY  F+  +++    ++ R+D +FI+  V
Sbjct:    1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP--EDQLPLDYA----KIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCP------NRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAR-----EDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCAL-VSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDI-RKRNYVRDDAVFIRAAV 462
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF2 (TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032])

HSP 1 Score: 113.62 bits (283), Expect = 3.129e-26
Identity = 107/486 (22.02%), Postives = 201/486 (41.36%), Query Frame = 2 
Query:  146 GVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAI--------DRPMNNKISRLIIKCPEN---------------------------SCDYVDELRKIELHIS-QCNSQTIICPYIKIGCNESDVSL-----------------GKMPDHLRNDIHNHTKLLMDC-IDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNR-NSTNPINLTAVSNKIDDAMK-FGLTKLA--DMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            G ++++  +C  C  V+     A CG R+C  C+++ L+      P N   C  E I  EE I+I        D     ++  L   CP +                           +C  +  L + E H+  +C  +++ C + +  C  +DV                    K+P   R    +H K    C +    + +  ++ + G  + + +     +     + S L+ + +  D        L+  + +++     E++  +++          +  +R +  +   + A+S+K+    +  GL  LA  D+E  +  M++      F+WK+  F  K + A  G+  +IFS +FYT +YGYKMCL+++ NG+      +LS+F  +MK   D +L WPF    T  L++Q  R   +   R   T  +FQ      +P+ + N+  G   F  + ++   + + R+D IFIK  V
Sbjct:   25 GTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSG----PQNCAACVHEGI-YEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIP---REKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQ------RPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 108.612 bits (270), Expect = 1.194e-24
Identity = 107/451 (23.73%), Postives = 203/451 (45.01%), Query Frame = 2 
Query:  155 VDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQ-FDKNTNDQSYW-----AEIESKLQQQTM---EIDLLK-QRV-----HNLENLDFVDRPKLK----AESLNNIISDNFRNYPNRLDTLNRNST----NPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            V+    C  C  V+ +     CG RFC  C++  L+     C      C+  ++  ++ +  D     +I  L I C   S    ++L    L +   N     C + ++ C   D     +   LR+ +    K       +  +++  I + V   + +  +KN + QS        EIE + Q++ +   E  +L  QRV       L+ LD   RP  +    A+S+ + + ++ +N    L+++++++     N   L +  ++ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   T  L++Q +   H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:   47 VEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQESIV--KDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKND----CHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSV-ESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 480
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 108.227 bits (269), Expect = 2.749e-24
Identity = 96/413 (23.24%), Postives = 185/413 (44.79%), Query Frame = 2 
Query:  266 RENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELR-KIELHISQCNSQTIICPYIKIGC-------------NESDVSLGKMPDHLRNDIHNHTKLLMD-------CIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNL-ENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            RE  C   K   ++ +I+L+++   D P       +++ CP + C     LR ++  H+S+C +    C + + GC               S V    +     N +     LL +        I +L+N++   +I     + Q +   N++S    ++  +  Q  ++  L + +    +N +  D  K   ESL N +++   +       + RN+     L +  ++ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   T  L++Q +   H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:  173 REATCSHCKS--QVPMIALQKHEDTDCPC------VVVSCP-HKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI---EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTE-LESVDKSAGQVARNTGL---LESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 563
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 108.227 bits (269), Expect = 2.749e-24
Identity = 96/413 (23.24%), Postives = 185/413 (44.79%), Query Frame = 2 
Query:  266 RENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELR-KIELHISQCNSQTIICPYIKIGC-------------NESDVSLGKMPDHLRNDIHNHTKLLMD-------CIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNL-ENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            RE  C   K   ++ +I+L+++   D P       +++ CP + C     LR ++  H+S+C +    C + + GC               S V    +     N +     LL +        I +L+N++   +I     + Q +   N++S    ++  +  Q  ++  L + +    +N +  D  K   ESL N +++   +       + RN+     L +  ++ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   T  L++Q +   H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:  173 REATCSHCKS--QVPMIALQKHEDTDCPC------VVVSCP-HKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI---EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTE-LESVDKSAGQVARNTGL---LESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 563
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-1 (TNF Receptor Associated Factor (TRAF) homolog; TRF-1 [Source:UniProtKB/TrEMBL;Acc:G5EG80])

HSP 1 Score: 94.3597 bits (233), Expect = 1.889e-20
Identity = 56/170 (32.94%), Postives = 88/170 (51.76%), Query Frame = 2 
Query:  920 TKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKM--CLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTY--DNFQM---EKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            T++         M   + +WK+DK   +   AK G   +IFS  F +H++GYKM  C  LF +G++  A   +S+++ L+K + D  LEWPF      SL++Q  R P  R   TY  D  ++   EK L +P  ERN  +G   F  L  L N   + ++D+I+++  V
Sbjct:  248 TRILSAAETCTEMFGPQLIWKIDKLQQRTNEAKSGADTTIFSVPFMSHRFGYKMMACACLFGDGSS--AGKSISLYVLLLKGEFDPTLEWPFHRAIKISLLDQNPR-PEDRVNITYVIDPRKLKANEKFLARPRGERNAAFGSQSFCSLAILQN---YVKDDKIYVQIDV 411
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-2 (TNF Receptor Associated Factor (TRAF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N586])

HSP 1 Score: 92.8189 bits (229), Expect = 2.037e-20
Identity = 48/135 (35.56%), Postives = 78/135 (57.78%), Query Frame = 2 
Query: 1004 MKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            +KA K     SI+S  FY+H YGYKM     P G+      Y SVF+CLMK + DDILEWPFR   TFS+++   +   +++    +  ++++ L++P   RN  +G+ +F+ L ++    ++  +  IFI+ KV
Sbjct:  172 VKATKNKSHRSIYSQPFYSHGYGYKMMAVAAPYGDGLAFREYFSVFVCLMKGEWDDILEWPFRCDVTFSILSDDKKELLTKTIYVNEMPEIQEFLERPEGLRNGTFGFQNFLPLAKV---TEFAADGDIFIQIKV 303
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0077429)

HSP 1 Score: 88.1965 bits (217), Expect = 2.710e-18
Identity = 50/189 (26.46%), Postives = 97/189 (51.32%), Query Frame = 2 
Query:  872 LTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRST------TTYDNFQMEKCLDKPILERN-VGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            + A+S++    ++   + ++ + +N     +   +WK+  ++ KM  A+    L + S  FYT QYGYK+   +F NGN    N ++SV++ ++  + D +L+WPF +  TF+L  Q  +              T++NFQ      +P  E + +G+G+  F+   EL ++  + + D +F++ KV  S
Sbjct:  304 MVALSSRQGQQIQMLKSAVSKLSINY----TGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQ------RPSNEPDQLGFGFPRFIS-HELLHSRPFIKGDTVFLRVKVDPS 481
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0334401)

HSP 1 Score: 88.1965 bits (217), Expect = 2.820e-18
Identity = 50/189 (26.46%), Postives = 97/189 (51.32%), Query Frame = 2 
Query:  872 LTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRST------TTYDNFQMEKCLDKPILERN-VGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            + A+S++    ++   + ++ + +N     +   +WK+  ++ KM  A+    L + S  FYT QYGYK+   +F NGN    N ++SV++ ++  + D +L+WPF +  TF+L  Q  +              T++NFQ      +P  E + +G+G+  F+   EL ++  + + D +F++ KV  S
Sbjct:  295 MVALSSRQGQQIQMLKSAVSKLSINY----TGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQ------RPSNEPDQLGFGFPRFIS-HELLHSRPFIKGDTVFLRVKVDPS 472
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf6 (gene:FBgn0265464 transcript:FBtr0071188)

HSP 1 Score: 49.6766 bits (117), Expect = 5.488e-6
Identity = 36/152 (23.68%), Postives = 64/152 (42.11%), Query Frame = 2 
Query:  155 VDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENS--CDYVDELRKIELHISQC------NSQTIICPYIKIGCN-ESDVSLGKMPDHLRNDIHNHTKLLMDCIDN 583
            +DS   C +C   +       CG RFC  C++ ++      CP +      + +S E +I  D     +I +L   CP +S  C  V    ++  H+  C        Q   CP+ KI C+        ++ +HL+ D+ +H +L++     
Sbjct:   98 LDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDN-----KRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQ 244
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf3 (TNF receptor-associated factor 3 [Source:ZFIN;Acc:ZDB-GENE-040801-257])

HSP 1 Score: 112.464 bits (280), Expect = 7.230e-26
Identity = 89/374 (23.80%), Postives = 177/374 (47.33%), Query Frame = 2 
Query:  377 IKCPENSCDYVDELR-KIELHISQCNSQTIICPYIKIGCN---------ESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLL----KQRVHNLENLDFVDRPKLKA-----ESLNNIISDNFRNYPNRLDTLNRNSTNPIN-LTAVSNKI---DDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            + CP N C +   LR ++  H   C    + C +I+ GC+         E + S     +HLR     +T L    ++++ +E+ E   ++ +   +  +         E   +L+Q+ + + +L     +++  +E ++  +   L+A     E+L   + ++ R+  + LD+   NS +  + L ++  ++   DD M     +LA+M++ L+ +++  F    +WK+  +  + + A   KTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L+WPF+   T  L++Q     H       D         +P  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:  204 VACP-NHCSFSSILRSELSSHQHDCPKAQVTCSFIRYGCSYKGLNQEMREHESSFAS--EHLRMMAVRNTTLEAK-VEDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNRQLEQKLVSMQMLMSSHSEKLLEVE-MELRELRPLRAMREEVETLRGSV-ESMRSMVSSLDSSCVNSASGSHTLASLEQQLTRHDDLMSVHDVRLAEMDLKLQVLETASFNGTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLQWPFKQKVTLMLMDQGPARKHLGDAFKPDP--SSSSFRRPTGEMNIASGCPLFVA-QTVLENGTYIKDDTIFIKVTVDTS 568
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf2b (Tnf receptor-associated factor 2b [Source:ZFIN;Acc:ZDB-GENE-030131-5345])

HSP 1 Score: 111.309 bits (277), Expect = 1.495e-25
Identity = 86/340 (25.29%), Postives = 156/340 (45.88%), Query Frame = 2 
Query:  422 KIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLN------NEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLN-NIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            K + H   C      C + +IGC  + V   K  +H +  I  H +L++  + ++        E  E  + +G ++G  D                 Q+         +V  LEN+  V   +++  +L    IS   R    +++ L+ N    +  T  +  +         +LA+ E +L+ ++  +++  F+WK+ +F+ + + A  G+  ++FS +FY+ +YGYKMCL+L+ NG+     ++LS+F  +MK   D +L+WPF    T  L++Q  R   +   R   +  +FQ      +PI E N+  G   F  L +L     + R+D IFIK
Sbjct:  212 KFQEHTKSCAKSKSACQFREIGCR-AVVDNCKQQEHEQTSIMEHLRLMLALLSSMRLRAEGAGEWQE-DVGLGLYRGPEDAPPAGAHNVGRGGGPGVQK---------KVTTLENIVCVLNKEVERSALTMEAISRQHRLDQEKIENLS-NKVRQLERTLTTRDL---------QLAESEQSLRELQFCTYDGVFIWKIAEFSRRRQDAVAGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGSHLSLFFVVMKGKYDALLKWPFSQKVTLMLLDQNNREHIIDAFRPDVSSTSFQ------RPISEMNIASGCPLFCPLAKLAGKSSYLRDDTIFIK 524
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf2b (Tnf receptor-associated factor 2b [Source:ZFIN;Acc:ZDB-GENE-030131-5345])

HSP 1 Score: 111.309 bits (277), Expect = 1.495e-25
Identity = 86/340 (25.29%), Postives = 156/340 (45.88%), Query Frame = 2 
Query:  422 KIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLN------NEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLN-NIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            K + H   C      C + +IGC  + V   K  +H +  I  H +L++  + ++        E  E  + +G ++G  D                 Q+         +V  LEN+  V   +++  +L    IS   R    +++ L+ N    +  T  +  +         +LA+ E +L+ ++  +++  F+WK+ +F+ + + A  G+  ++FS +FY+ +YGYKMCL+L+ NG+     ++LS+F  +MK   D +L+WPF    T  L++Q  R   +   R   +  +FQ      +PI E N+  G   F  L +L     + R+D IFIK
Sbjct:  212 KFQEHTKSCAKSKSACQFREIGCR-AVVDNCKQQEHEQTSIMEHLRLMLALLSSMRLRAEGAGEWQE-DVGLGLYRGPEDAPPAGAHNVGRGGGPGVQK---------KVTTLENIVCVLNKEVERSALTMEAISRQHRLDQEKIENLS-NKVRQLERTLTTRDL---------QLAESEQSLRELQFCTYDGVFIWKIAEFSRRRQDAVAGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGSHLSLFFVVMKGKYDALLKWPFSQKVTLMLLDQNNREHIIDAFRPDVSSTSFQ------RPISEMNIASGCPLFCPLAKLAGKSSYLRDDTIFIK 524
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf2b (Tnf receptor-associated factor 2b [Source:ZFIN;Acc:ZDB-GENE-030131-5345])

HSP 1 Score: 110.923 bits (276), Expect = 2.220e-25
Identity = 86/340 (25.29%), Postives = 156/340 (45.88%), Query Frame = 2 
Query:  422 KIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLN------NEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLN-NIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            K + H   C      C + +IGC  + V   K  +H +  I  H +L++  + ++        E  E  + +G ++G  D                 Q+         +V  LEN+  V   +++  +L    IS   R    +++ L+ N    +  T  +  +         +LA+ E +L+ ++  +++  F+WK+ +F+ + + A  G+  ++FS +FY+ +YGYKMCL+L+ NG+     ++LS+F  +MK   D +L+WPF    T  L++Q  R   +   R   +  +FQ      +PI E N+  G   F  L +L     + R+D IFIK
Sbjct:  225 KFQEHTKSCAKSKSACQFREIGCR-AVVDNCKQQEHEQTSIMEHLRLMLALLSSMRLRAEGAGEWQE-DVGLGLYRGPEDAPPAGAHNVGRGGGPGVQK---------KVTTLENIVCVLNKEVERSALTMEAISRQHRLDQEKIENLS-NKVRQLERTLTTRDL---------QLAESEQSLRELQFCTYDGVFIWKIAEFSRRRQDAVAGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGSHLSLFFVVMKGKYDALLKWPFSQKVTLMLLDQNNREHIIDAFRPDVSSTSFQ------RPISEMNIASGCPLFCPLAKLAGKSSYLRDDTIFIK 537
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf4a (tnf receptor-associated factor 4a [Source:ZFIN;Acc:ZDB-GENE-040308-1])

HSP 1 Score: 109.383 bits (272), Expect = 3.546e-25
Identity = 107/479 (22.34%), Postives = 191/479 (39.87%), Query Frame = 2 
Query:  125 MENYDFSGVEVDSDMI-CGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFV----------------------DRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M  +D+  +E       C LC K M      + CG RFC  C+  +L+     CP  +D   L+       I  D  +  +I  L I+C   E  C +  ++++++ H S C    I CP      N   V L +  +P+HL++D          C      E  E    +   +  + +N         +   L Q TM     + +       +FV                        P +  E L N + ++  +             +     A+   ++++ K  LT +  + V  +R +  E                +WK+  ++ K++ AK       FS  FYTH+YGYK+ +  F NGN     ++LS+++ ++  + D++LEWPF    TFS+++Q     ++  H   T      + NFQ        + E  +G+GY  F+  +E+    ++ R++ IF+K  +
Sbjct:    1 MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP--EDQLPLDYA----KIYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQSHFSTCAFNVIPCP------NRCSVKLTRRDLPEHLQHDCPKRKVKCEFCGSEFTGEAYENHQGICPQESVYCENKCGARMMRRL---LSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPNQCGTPNIAREDLANHVKESCGSALVLCPFKEAGCKHRCPKMAIGRHLEESTKSHLTMMCSL-VGRQRQEILELRREMEELSVSHDGVLIWKLTDYSRKLQEAKLRNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSIYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQKPCSSRNSLDESTLGFGYPKFISHEEI-KKRNYIRDNSIFLKASI 462
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 113.62 bits (283), Expect = 3.543e-26
Identity = 99/420 (23.57%), Postives = 187/420 (44.52%), Query Frame = 2 
Query:  269 ENLCPGNKDDCK-----LELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELR-KIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMD---------------------CIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENL-DFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNST--NPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            E  C   +  CK     + L+ ++++  +D P       ++I CP + C     LR ++  H+ +C +    C + + GC     +  ++  H  +    H  L+ +                      I  L+N+M   +I +   K Q     N+++   +++  ++ Q  ++  L + + NL    D  D  K   ESL N +S        +L+ + +N+   NP  L    N+ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   +  L++Q     H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:  162 EKTCKYRETPCKFCRNQVPLVEMQKHEDVDCP------SVVISCP-HMCSVKSLLRSELNAHLLECVNAPSTCSFKRYGCTFKGTN-QQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQL---RNNEARIIQLQRVIEGQADKLKDLDKEIRNLRQTGDEADGMKSNYESLQNRLS--------QLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 556
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 110.923 bits (276), Expect = 2.526e-25
Identity = 115/509 (22.59%), Postives = 205/509 (40.28%), Query Frame = 2 
Query:  155 VDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDD-----------CKLELISLE----------------ENIAIDRPMNNKISRLIIKCPENSC-------DYVDELRKI----ELHISQCNSQTII----------CPYIKIGCN---------ESDVSLGKMPDHLRNDIHNHTKLLMD---------------------CIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENL-DFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNST--NPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            V+    C  C  V+ N     CG RFC  C++  L+     C   +D+           C+ E+++L+                 N+ I    + +   L   CP   C       D  D + K     E     C +Q  +          CP + I C           S+ +  ++  H  +    H  L+ +                      I  L+N+M   +I +   K Q     N+++   +++  ++ Q  ++  L + + NL    D  D  K   ESL N +S        +L+ + +N+   NP  L    N+ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   +  L++Q     H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:   42 VEEKYKCEKCRLVLCNPRQTECGHRFCETCMNAILSSTSPQCMACEDNITKDKVFKDNCCRREVLALQMFCRNETRGCKELITLGNLLIHLKSDCQFEEL--SCPRADCKEKVIRKDLSDHIEKTCKYRETPCKFCRNQVPLVEMQKHEDVDCPSVVISCPHMCSVKSLLRSEGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQL---RNNEARIIQLQRVIEGQADKLKDLDKEIRNLRQTGDEADGMKSNYESLQNRLS--------QLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 531
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 105.916 bits (263), Expect = 6.748e-24
Identity = 102/446 (22.87%), Postives = 187/446 (41.93%), Query Frame = 2 
Query:  146 GVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLN------GRENLCPG--NKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHIS-QCNSQTIICPYIKIGCNESDVSL-----GKMPDHL----RNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKR--MKSFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            G +++   +C  C  ++     A CG R+C  C++  +       G    CP    + D    LIS+            K   L+  CP  +C  +      +LH   +C  + + C Y K+     D+        K P       R  I      L  C+      +   ++ V N K    +N +   + A+  S         +   +    L   D +D+     E++ ++++       +  + L R       L A   +++  +      +A++E  ++   + +++  F+WK+ +F  K + A  G+  ++FS  FYT++YGYKMCL+++ NG+    N +LS+F  +MK + D +L WPF    T  L++Q  R   +   R   +  +FQ      +PI E N+  G   F  + +L   + + R+D IF+K  V
Sbjct:   28 GTKLEVKYLCSDCKNLLRRPLQAQCGHRYCSHCLNKIIRWVARNWGGVPECPAVCERSDWTGALISVGHE--------GKCPYLLAPCP--ACKTIIRAANRDLHSERECPERKLNCRYCKLSFYFPDIKAHDEICPKFPMTCEGCGRKKIPREKVRLFVCMPCRYAAVGCTEM-VENDKCLEHENKSLAEHLAK-GSPAPPANAPPNNSAKVAEMLLKFDTLDKKNTTFENIVSVLNREVERSSHAAEELARQ------LRAADTRLERTLGQKELIVAELETRMQESELSTYDGVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVSSSSFQ------RPISEMNIASGCPLFCQVSKLEGKNSYVRDDTIFVKVIV 449
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 105.916 bits (263), Expect = 7.576e-24
Identity = 77/325 (23.69%), Postives = 145/325 (44.62%), Query Frame = 2 
Query:  458 TIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENL-DFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKR--MKSFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            ++ C Y  +GC E  V   K  +H    +  H   + D I +   E N++ + +G+   Q                         D L ++    EN+   ++R   ++      ++   R    +++ L          T    +++  +      +A++E  ++   + +++  F+WK+ +F  K + A  G+  ++FS  FYT++YGYKMCL+++ NG+    N +LS+F  +MK + D +L WPF    T  L++Q  R   +   R   +  +FQ      +PI E N+  G   F  + +L   + + R+D IF+K  V
Sbjct:  187 SLPCRYAAVGCTEM-VENDKCLEHENKSLAEHLAKVWDYIQHGRKEQNDLSVRMGSLSVQ------------------GSPAPPFDTLDKKNTTFENIVSVLNREVERSSHAAEELARQLRAAQEKVEAL----------TTKVRQLERTLGQKELIVAELETRMQESELSTYDGVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVSSSSFQ------RPISEMNIASGCPLFCQVSKLEGKNSYVRDDTIFVKVIV 476
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: slc12a1 (solute carrier family 12 member 1 [Source:Xenbase;Acc:XB-GENE-479925])

HSP 1 Score: 95.5153 bits (236), Expect = 2.073e-20
Identity = 91/370 (24.59%), Postives = 154/370 (41.62%), Query Frame = 2 
Query:  377 IKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVG-----NFKGQFDKNTNDQSYWAEIE-SKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNR--LDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLAD---------MEVNLKRMKSFE-------FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFN--NDDWTRNDQIFIKFKV 1408
            + CP N+C       +++ H+ +C    + C +   GCN   V  GK+ +H    + +H   +      LN  M   + ++G     + K    +  +D   W E E  +  Q T            L +  ++D+     E +  ++S        R  LDTL         L A  ++ID+    G  K  D         M  N +R +  E        +WK+  +  K + A +G+ +SIFS  FYT   GY++C + + NG+     ++LS++  +MK + D IL WPF+   T  L++Q  +  H   T  +          +P  E N+  G   F    +L N  N  + ++D +FIK  V
Sbjct:  125 VPCP-NACPVTCPRAELDKHLCECPEAELQCTFSNYGCNVM-VKRGKVKEHEDTFLRDHMLYV------LNRNMKLEEQVLGLQQNLDLKEHQIQQLSDTVKWCEKECHQFGQFTGSNGNSLSSTKTLAS--YIDKSMWLEEQVIQLVSKEHSRLDLRPILDTLESTKQRLSTLEAYKDRIDNLD--GQFKKHDVLLSNHKMQMTSNEERFRLVEGTSYNGKLIWKITDYERKKREAMEGRAVSIFSQHFYTSWCGYRLCARAYLNGDGSGKGSFLSLYFVVMKGEFDSILLWPFKQKVTLMLLDQSGKKNH--ITDVFRADPNSSSFKRPDSEMNIASGCPRFASHAQLENPKNGCYIKDDTLFIKIVV 480
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf4 (TNF receptor associated factor 4 [Source:MGI Symbol;Acc:MGI:1202880])

HSP 1 Score: 119.398 bits (298), Expect = 1.614e-28
Identity = 108/481 (22.45%), Postives = 195/481 (40.54%), Query Frame = 2 
Query:  125 MENYDFSGVE-VDSDMICGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEI----------------------KIIVGNFKGQFDKNTNDQSYWAE--IESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M  +D+  +E     ++C LCGK M      + CG RFC  C+  +L+     CP  +D   L+       I  D  +  ++  L I+C   E  C +   LR ++ H++ C+   + CP      N     L +  +P HL++D          C  + + E  E                       +++  +   +  K T   +Y  +  +   +Q    +   L     N   +  V R  L    L +  S  F   P +               A+   +++++K  L  +  + V+ +R +  E                +WK+  +  +++ AK    L  FS +FYTH+YGYK+ +  F NGN      +LS+++ ++    D++LEWPF    TFSL++Q      +  H   T      + NFQ        + E ++G+GY  F+  +++    ++ R+D +FI+  V
Sbjct:    1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP--EDQLPLDYA----KIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCP------NRCPAKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGVGTVAREDLPTH-LKDSCSTAFVLCPFKESGCKHRCPK----LAMGRHVEESVKPHLAMMCAL-VSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDI-RKRNYVRDDAVFIRASV 462
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 114.39 bits (285), Expect = 1.119e-26
Identity = 88/335 (26.27%), Postives = 150/335 (44.78%), Query Frame = 2 
Query:  434 HISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMK-FGLTKLA--DMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            H+  C+   ++C +  +GC+E  V    + DH    +  H  LL+                    + Q    T +Q     +  +L Q+     +L+Q++   EN+  V    L  E     ++    +  +RLD           + A+SNK+    +  GL  LA  D+E  +  ++       F+WK+  F  K + A  G+T +IFS +FYT +YGYKMCL+++ NG+      +LS+F  +MK   D +L+WPF    T  L++   R   +   R   T  +FQ      +P+ + N+  G   F  + ++   + + R+D IFIK  V
Sbjct:  212 HVRACSKCRVLCRFHTVGCSEM-VETENLQDHELQRLREHLALLLSSF----------------LEAQASPGTLNQ-----VGPELLQRC---QILEQKIATFENIVCV----LNREVERVAVTAEACSRQHRLDQ--------DKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQ------RPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 503
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 114.39 bits (285), Expect = 1.218e-26
Identity = 88/336 (26.19%), Postives = 151/336 (44.94%), Query Frame = 2 
Query:  434 HISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENL-----DFVDRPKLKAESLNN---IISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            H+  C+   ++C +  +GC+E  V    + DH    +  H  LL+                    + Q    T +Q     +  +L Q+     +L+Q++   EN+       V+R  + AE+ +    +  D      N++  L R+    I L       D AM     K++++EV+        F+WK+  F  K + A  G+T +IFS +FYT +YGYKMCL+++ NG+      +LS+F  +MK   D +L+WPF    T  L++   R   +   R   T  +FQ      +P+ + N+  G   F  + ++   + + R+D IFIK  V
Sbjct:  205 HVRACSKCRVLCRFHTVGCSEM-VETENLQDHELQRLREHLALLLSSF----------------LEAQASPGTLNQ-----VGPELLQRC---QILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERS----IGLK------DLAMADLEQKVSELEVS---TYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQ------RPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf1 (TNF receptor-associated factor 1 [Source:MGI Symbol;Acc:MGI:101836])

HSP 1 Score: 106.686 bits (265), Expect = 1.838e-24
Identity = 89/346 (25.72%), Postives = 161/346 (46.53%), Query Frame = 2 
Query:  461 IICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRN-STNPINLTAV--SNKIDDAMKFGLTK---------------LADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHS----RSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFN-NDDWTRNDQIFIKFKVHSS 1417
            I+CP+  +GC+    S   M +H      +H  LL+  +    +        +G+     ++N ++    A +E+      +E+D    R    E+ + +    L  E L   + +  R + N +  LN+    + + L A    +++D      L +               L  +E +L+ M+  SF+  F+WK+     +   +  G+T+S+FS +FYT +YGYK+CL+L+ NG+      +LS+F+ +M+ + D +L WPFRN  TF L++Q  R  H+    R   +  +FQ      +P  E NV  G   F  L +L +    + ++D +F+K  V +S
Sbjct:   79 IMCPFAGVGCSFKG-SPQSMQEHEATSQSSHLYLLLAVLKEWKSSPGSN---LGSAPMALERNLSELQLQAAVEAT---GDLEVDCY--RAPCCESQEELALQHLVKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLDREHILSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPDLSSASFQ------RPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTS 408
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf1 (TNF receptor-associated factor 1 [Source:MGI Symbol;Acc:MGI:101836])

HSP 1 Score: 106.686 bits (265), Expect = 1.838e-24
Identity = 89/346 (25.72%), Postives = 161/346 (46.53%), Query Frame = 2 
Query:  461 IICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRN-STNPINLTAV--SNKIDDAMKFGLTK---------------LADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHS----RSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFN-NDDWTRNDQIFIKFKVHSS 1417
            I+CP+  +GC+    S   M +H      +H  LL+  +    +        +G+     ++N ++    A +E+      +E+D    R    E+ + +    L  E L   + +  R + N +  LN+    + + L A    +++D      L +               L  +E +L+ M+  SF+  F+WK+     +   +  G+T+S+FS +FYT +YGYK+CL+L+ NG+      +LS+F+ +M+ + D +L WPFRN  TF L++Q  R  H+    R   +  +FQ      +P  E NV  G   F  L +L +    + ++D +F+K  V +S
Sbjct:   79 IMCPFAGVGCSFKG-SPQSMQEHEATSQSSHLYLLLAVLKEWKSSPGSN---LGSAPMALERNLSELQLQAAVEAT---GDLEVDCY--RAPCCESQEELALQHLVKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLDREHILSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPDLSSASFQ------RPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTS 408
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|P39429|TRAF2_MOUSE (TNF receptor-associated factor 2 OS=Mus musculus OX=10090 GN=Traf2 PE=1 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 8.519e-26
Identity = 88/336 (26.19%), Postives = 151/336 (44.94%), Query Frame = 2 
Query:  434 HISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENL-----DFVDRPKLKAESLNN---IISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            H+  C+   ++C +  +GC+E  V    + DH    +  H  LL+                    + Q    T +Q     +  +L Q+     +L+Q++   EN+       V+R  + AE+ +    +  D      N++  L R+    I L       D AM     K++++EV+        F+WK+  F  K + A  G+T +IFS +FYT +YGYKMCL+++ NG+      +LS+F  +MK   D +L+WPF    T  L++   R   +   R   T  +FQ      +P+ + N+  G   F  + ++   + + R+D IFIK  V
Sbjct:  205 HVRACSKCRVLCRFHTVGCSEM-VETENLQDHELQRLREHLALLLSSF----------------LEAQASPGTLNQ-----VGPELLQRC---QILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERS----IGLK------DLAMADLEQKVSELEVS---TYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQ------RPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q12933|TRAF2_HUMAN (TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2)

HSP 1 Score: 113.62 bits (283), Expect = 1.503e-25
Identity = 107/486 (22.02%), Postives = 201/486 (41.36%), Query Frame = 2 
Query:  146 GVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAI--------DRPMNNKISRLIIKCPEN---------------------------SCDYVDELRKIELHIS-QCNSQTIICPYIKIGCNESDVSL-----------------GKMPDHLRNDIHNHTKLLMDC-IDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNR-NSTNPINLTAVSNKIDDAMK-FGLTKLA--DMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            G ++++  +C  C  V+     A CG R+C  C+++ L+      P N   C  E I  EE I+I        D     ++  L   CP +                           +C  +  L + E H+  +C  +++ C + +  C  +DV                    K+P   R    +H K    C +    + +  ++ + G  + + +     +     + S L+ + +  D        L+  + +++     E++  +++          +  +R +  +   + A+S+K+    +  GL  LA  D+E  +  M++      F+WK+  F  K + A  G+  +IFS +FYT +YGYKMCL+++ NG+      +LS+F  +MK   D +L WPF    T  L++Q  R   +   R   T  +FQ      +P+ + N+  G   F  + ++   + + R+D IFIK  V
Sbjct:   25 GTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSG----PQNCAACVHEGI-YEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIP---REKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQ------RPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|P39428|TRAF1_MOUSE (TNF receptor-associated factor 1 OS=Mus musculus OX=10090 GN=Traf1 PE=1 SV=2)

HSP 1 Score: 106.686 bits (265), Expect = 1.286e-23
Identity = 89/346 (25.72%), Postives = 161/346 (46.53%), Query Frame = 2 
Query:  461 IICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRN-STNPINLTAV--SNKIDDAMKFGLTK---------------LADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHS----RSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFN-NDDWTRNDQIFIKFKVHSS 1417
            I+CP+  +GC+    S   M +H      +H  LL+  +    +        +G+     ++N ++    A +E+      +E+D    R    E+ + +    L  E L   + +  R + N +  LN+    + + L A    +++D      L +               L  +E +L+ M+  SF+  F+WK+     +   +  G+T+S+FS +FYT +YGYK+CL+L+ NG+      +LS+F+ +M+ + D +L WPFRN  TF L++Q  R  H+    R   +  +FQ      +P  E NV  G   F  L +L +    + ++D +F+K  V +S
Sbjct:   79 IMCPFAGVGCSFKG-SPQSMQEHEATSQSSHLYLLLAVLKEWKSSPGSN---LGSAPMALERNLSELQLQAAVEAT---GDLEVDCY--RAPCCESQEELALQHLVKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLDREHILSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPDLSSASFQ------RPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTS 408
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q13114|TRAF3_HUMAN (TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2)

HSP 1 Score: 108.227 bits (269), Expect = 1.320e-23
Identity = 96/413 (23.24%), Postives = 185/413 (44.79%), Query Frame = 2 
Query:  266 RENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELR-KIELHISQCNSQTIICPYIKIGC-------------NESDVSLGKMPDHLRNDIHNHTKLLMD-------CIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNL-ENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            RE  C   K   ++ +I+L+++   D P       +++ CP + C     LR ++  H+S+C +    C + + GC               S V    +     N +     LL +        I +L+N++   +I     + Q +   N++S    ++  +  Q  ++  L + +    +N +  D  K   ESL N +++   +       + RN+     L +  ++ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   T  L++Q +   H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:  173 REATCSHCKS--QVPMIALQKHEDTDCPC------VVVSCP-HKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI---EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTE-LESVDKSAGQVARNTGL---LESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 563
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q60803|TRAF3_MOUSE (TNF receptor-associated factor 3 OS=Mus musculus OX=10090 GN=Traf3 PE=1 SV=2)

HSP 1 Score: 107.842 bits (268), Expect = 1.790e-23
Identity = 100/414 (24.15%), Postives = 196/414 (47.34%), Query Frame = 2 
Query:  266 RENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELR-KIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYW-----AEIESKLQQQTM---EIDLLK-QRV-----HNLENLDFVDRPKLK----AESLNNIISDNFRNYPNRLDTLNRNSTNPIN----LTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQME---KCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            RE  C   K   ++ +I L+++   D P       +++ CP + C     LR ++  H+S+C +    C + + GC     +  ++  H  +    H  LL +  ++L  +++ ++          +KN + QS        EIE + Q++ +   E  +L  QRV       L+ LD   RP  +    A+S+ + + ++ +N    L+++++++         L +  ++ D  +     +LADM++  + +++  +    +WK+  +  + + A  GKTLS++S  FYT  +GYKMC +++ NG+      +LS+F  +M+ + D +L WPF+   T  L++Q +   H       D F+ +       KP  E N+  G   F+  + +  N  + ++D IFIK  V +S
Sbjct:  172 REATCSHCKS--QVPMIKLQKHEDTDCPC------VVVSCP-HKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTN-QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQ------NESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSV-ESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH-----LGDAFKPDPNSSSFKKPTGEMNIASGCPVFV-AQTVLENGTYIKDDTIFIKVIVDTS 562
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 179.874 bits (455), Expect = 5.254e-47
Identity = 125/454 (27.53%), Postives = 229/454 (50.44%), Query Frame = 2 
Query:   89 MAKFKFENIWKIMENYDFSGVE--VDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMN-----------EIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMK--FGLTKLADME--------VNLKRMKSF------EFVWKVDKFNDKMKAAKKGKTLS-IFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQM-EKCLDKPILERN---------VGYGYL 1330
            M   K +N+ +++  Y+   V+  V++D++C LC K+M ++  + CGC +C  CI  YL+   N CPG+K +CK + ++LE ++  +  ++ +ISR+++KCP   C+Y  EL +++ H+ +C  +++ CP + IGC E  +   +M  HL + +  HT+L+M   + L +E+N            +K ++   K   D+ T    +  E   +L+ +   I +L Q +  ++N + +     K   L  + SD  + +   ++ + +N    +  T + N++ D  K  FG+    D           NL R+         +F+W+++++      +KK +T++ ++SDSF +H   YK CL L+  G+       L ++  +MK + DD LEWP R   T S+I Q +   H  +   YD +Q  +K  D+P  ERN         V Y Y+
Sbjct:    1 MIPSKLDNVQELLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYLNLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLDKCTPESVECPCVTIGCEEEPLLKDEMAKHLTDQVLRHTQLIMSFCNELKSEINHNNETTKEDISHLKEVLRVQKALNDEKTAQMEFLIE---ELRNKDNMILVLSQDIQEVKN-EMITLLTSKESELKKLKSD-IQIFRQEIEFM-KNDLEVVGSTDIKNQVKDLKKEIFGIKMNIDSNNEERERKMNNLIRLNKLCPNVDMDFMWRIEEY------SKKRRTVTDVYSDSFQSH--NYKFCLNLYIYGDN------LGLWCVIMKGEKDDFLEWPMRRTVTLSIIEQDSLKTHKTTVFQYDTYQRNKKAFDRPKDERNDYCIGTDSLVRYSYI 434
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BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A2B4SJ65 (TNF receptor-associated factor 4 OS=Stylophora pistillata OX=50429 GN=Traf4 PE=4 SV=1)

HSP 1 Score: 142.895 bits (359), Expect = 7.980e-34
Identity = 119/444 (26.80%), Postives = 208/444 (46.85%), Query Frame = 2 
Query:  131 NYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLEN--LDFVDRPKLKAESLNNIISDNFRNYPN----RLDTLNRNSTNPINLTAVSNKIDDAMKFG---LTKLADMEVNLKR--MKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLP-------HSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            +YDF   E+D D IC +C   + N+    CG RFC+DC++ +       CP ++     E +  ++++  D+    +I   +IKCP + C +V ELR +E H  +C       PY+ + C          P+H     + H ++  + ++       + +++   F          Q  + + E  +  +T  +  L     N  N     V R +++  +L   I ++  ++      +L  L +   N  N T +  ++DD  K     L K +  E  +++  M++  FVWKV  F+D ++ AK G+   + SD FYT +YGYK+ L + PNG+    N +LS F+ +M+ + D IL WPF +  TF+L++Q+  L        H R+ T  +NF       +P  E N G GY  F+  ++L     +  +D +FI+  V
Sbjct:   15 DYDFVS-EIDEDFICQICHLPLRNAVLTRCGHRFCVDCLNEHFRRNSPNCPLDR-----EKLDKDKDVFPDKASQRRILSYLIKCP-DKCQWVGELRDVEGHKKKC-------PYVIVQC----------PNH-----NCHERMARNLVEEHAAVTCQWRMVSCQFC---------QKKYPKAEEHIHCETCHMFPL-----NCSNGCEQVVPREQVERRNLETHIHEDTTSHLGFACKKLAVLQQ-EFNKENKT-LKKQLDDVKKENENLLLKASAQEKEMQKSKMETPTFVWKVTGFDDILRQAKHGRNNEMDSDPFYTGKYGYKLKLSVNPNGDGSGRNTHLSAFVIVMRGEHDGILPWPFNHKVTFTLVDQQESLDERENVVMHFRANTKLENFA------RPTAEENPGRGYARFVSHEKL-RTRRYLVDDTLFIQVDV 406
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A5K4F9L5 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 143.665 bits (361), Expect = 1.867e-33
Identity = 111/417 (26.62%), Postives = 195/417 (46.76%), Query Frame = 2 
Query:  218 CGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENS--CDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDT-LNRN---STNPINLTA--VSNKIDDAMKFGLTKLADMEVNLKRMKSFE------FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQ----RTRLP-----HSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            CG R C  C+ + L G    CP +K + K      ++ + +D+     +  L ++C  ++  C ++  L ++  H+SQC  + ++CP    GC  ++     + +H++ND     K    C          +K I    + + +   N + Y     +K ++  +   L+ + + N  +   +  P        N+    FR + N++DT L R+     N +NL+   +S  I+   K        +E  +KR+ + E      F+WK+D +++K+  AK GK  ++FS  FYTH+YGY+M L +   GN +    Y+SV+ CL + D D +L+WPF +  TF+LI+Q      R P     +   T  Y+ F       +P  ERN  +G   F+ L EL     +  ND+I++K
Sbjct:  105 CGHRCCSGCVPDILRGTSK-CPVDKQNLK------KDRVHLDKAFQEHMDGLNVRCSYHTEGCPWIGILSELGYHLSQCEYRIVLCPN---GCG-AESQRKSIENHIKNDCPKRIKRCKFC---------NVKYIA---EKEIEHTNNCREYPVPCPNKCEKTKIPRSLISEHLKNECSRQNIRCP-------FNVHGCEFRGHKNKIDTHLERSLMVHLNFLNLSVQQMSLLIEAQTKSYAETRKSLESQIKRVTALEQCLGAPFLWKIDSYSEKLNNAKSGKQTALFSSPFYTHRYGYRMALSVSLYGNGDARGKYMSVYACLFRGDHDSLLQWPFSHQLTFTLIDQNPEINARQPIVYTINPSITGDYNQF-----FGRPTNERNSCFGAPRFIKL-ELMEMSTYILNDEIYLK 485
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A3L7HD98 (TNF receptor-associated factor OS=Cricetulus griseus OX=10029 GN=CgPICR_012378 PE=3 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 1.889e-33
Identity = 113/443 (25.51%), Postives = 202/443 (45.60%), Query Frame = 2 
Query:  146 GVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLN-GRENLCPGNKDDCKLELISLEENIAI--DRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRN------DIHNHTKLLMDCIDNLNNEMNEIKIIVGNFK---GQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMK-FGLTKLA--DMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            G ++++  +C  C  ++     A CG R+C  C+++ L+ G +N      +    E IS+ E+ +   D     ++  L   CP + C +   L++ E+H   C    + C     GC +  +S  K  DH+R+          HT    + ++N   + +E+K +  +       F ++   Q   ++   ++ Q+      L+Q+    EN+  V    L  E     ++    +  +RLD           + A+SNK+    +  GL  LA  D+E  +  +++      F+WK+  F  K + A  G+T +IFS +FYT +YGYKMCL+++ NG+      +LS+F  +MK   D +L WPF    T  L++Q  R   +   R   T  +FQ      +P+ + N+  G   F  + ++   + + R+D IFIK  V
Sbjct:   25 GTKLEAKYLCSACRNILRRPFQAQCGHRYCSFCLNSILSSGPQNCAACVHEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYEVHYEVCPKFPLTCD----GCGKKKISREKFQDHVRSCNKCRVPCRFHTVGCSEMVENEELQDHEVKKLREHLALLLSSFLESPASQGSQSQAGPEMLQRCHS---LEQKTATFENIVCV----LNREVERVAVTAEACSRQHRLDQ--------DKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEASTYDGVFIWKISDFARKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQ------RPLSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 442
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A5K4F8V4 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 4.787e-33
Identity = 104/402 (25.87%), Postives = 189/402 (47.01%), Query Frame = 2 
Query:  218 CGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENS--CDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDT-LNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYD-----NFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            CG R C  C+ + L G    CP +K + K      ++ + +D+     +  L ++C  ++  C ++  L ++  H+SQC  + ++CP    GC  ++     + +H++ND     K    C          +K I    + + +   N + Y     +K ++  +   L+ + + N  +   +  P        N+    FR + N++DT L R+    +N   +S +    +    TK +  E  L++     F+WK+D +++K+  AK GK  ++FS  FYTH+YGY+M L +   GN +    Y+SV+ CL + D D +L+WPF +  TF+LI+Q   + ++R    Y           +   +P  ERN  +G   F+ L EL     +  ND+I++K
Sbjct:  105 CGHRCCSGCVPDILRGTSK-CPVDKQNLK------KDRVHLDKAFQEHMDGLNVRCSYHTEGCPWIGILSELGYHLSQCEYRIVLCPN---GCG-AESQRKSIENHIKNDCPKRIKRCKFC---------NVKYIA---EKEIEHTNNCREYPVPCPNKCEKTKIPRSLISEHLKNECSRQNIRCP-------FNVHGCEFRGHKNKIDTHLERSLMVHLNFLNLSVQQMSLLIEAQTK-SYAETPLEQCLGAPFLWKIDSYSEKLNNAKSGKQTALFSSPFYTHRYGYRMALSVSLYGNGDARGKYMSVYACLFRGDHDSLLQWPFSHQLTFTLIDQNPEI-NARQPIVYTINPSITGDYNQFFGRPTNERNSCFGAPRFIKL-ELMEMSTYILNDEIYLK 473
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:103028261])

HSP 1 Score: 110.153 bits (274), Expect = 2.801e-25
Identity = 86/347 (24.78%), Postives = 155/347 (44.67%), Query Frame = 2 
Query:  422 KIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWA------EIESKLQQQTMEIDLLKQRVHNLENL-----DFVDRPKLKAESLN---NIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMK--SFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            K   H   C      C + +IGC  + V  GK  +H ++ I  H +L++  +  +         +  +  G++ +++    Y                       ++Q++  LEN+       V+R  L+ E+L     +  +   N  N++  L R  T           + D       +LA+ E  L+ ++  +++  FVWK+  F+ + + A  G+  ++FS +FY+ +YGYKMCL+L+ NG+     ++LS+F  +M+   D +L+WPF    T  L++Q  R   +   R   +  +FQ      +PI E N+  G   F  L +L     + R+D IFIK
Sbjct:  209 KFAEHSKSCAKSKSACQFSEIGCR-AVVDNGKQHEHEQSSIIEHLRLMLAVLSTVR--------VRSDGPGEWQEDSGLGLYRGPEDAAPPGAHAAAHNAAGGPGVQQKMTALENIVCVLNREVERTVLRLEALTRQQQLDQEKIENLSNKVRQLERTLT-----------MRD------LQLAESEQALRELQFCTYDGVFVWKISDFSRRRQDALAGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGSHLSLFFVVMRGKYDALLKWPFSQKVTLMLLDQNNREHIIDAFRPDISSTSFQ------RPISEMNIASGCPLFCPLAKLAGKSSYLRDDTIFIK 523
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:103024022])

HSP 1 Score: 109.383 bits (272), Expect = 2.977e-25
Identity = 106/476 (22.27%), Postives = 191/476 (40.13%), Query Frame = 2 
Query:  125 MENYDFSGVEVDSDMI-CGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTND---------QSYWAEIESKLQQ-----QTMEIDLLKQRVHNLENLDF-----VDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M  YD+  +E       C LC K M      + CG RFC  C+  +L+     CP  +D   L+       I  D  +  +I  L I+C   E  C +  ++++++ H S C    I CP      N   V L +  +P+HL++D          C      E  E    +   +  + +N            Q   AE   + Q      +    D ++   ++              P +  E L   + ++  +        +    +     A+   +++  K  LT +  + V  +R +  E                +WK++ ++ K++ AK       FS  FYTH+YGYK+ +  F NGN     ++LS+++ ++  + D++LEWPF    TFS+++Q     ++  H   T      + NFQ        + E  +G+GY  F+   E+    ++ R++ IF+K  +
Sbjct:    1 MPGYDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP--EDQLPLDYA----KIYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCP------NRCAVKLTRRDLPEHLQHDCPKRKVKCEFCGSEFTGEAFENHQGICPQESVYCENKCGARMMRRLLAQHTMAECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPNQCGTPNIAREDLATHVKESCGSALVLCPFKDAGCKHRCPKLAIGRHLEETTKSHLTMMCSL-VGRQRQEIIELRREMEELSVSHDGVLIWKLNDYSRKLQEAKLHNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSIYIRVLPGEYDNLLEWPFAYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQKPSSSRNSLDESTLGFGYPKFISHDEI-RKRNYIRDNAIFLKASI 462
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 108.227 bits (269), Expect = 9.714e-25
Identity = 99/448 (22.10%), Postives = 190/448 (42.41%), Query Frame = 2 
Query:  155 VDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVS----------LGKMPDHLRNDIHNHTKLLMDC-IDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNL------------ENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGL-TKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQL-FPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNV-GYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            ++S   C +C   + ++   PCG RFC  CI   +      CP + +      +  E+ +  D     +I  L ++C    C    ELR +E HI  C   T+ CP  +    +S++           L   PD   N I+   +L   C  D L   +     I G  +       ND +   +  +++  + M   L  Q ++ L            ++     RP+   +    +     R     L++      + +   ++ N+        L  KLA +E +++ +++ ++    VW+++ F+  ++  + G  + + S  FYT + GYK+CL+L     NA   +NY+S+F+  M+ + D  L WP +     ++++Q     H     T  + Q      +P ++RN  G+GY+ FM L+ L +   + R+D + ++ +V
Sbjct:   64 LESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNE------VLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQLASHCDTDCLKAPVACTFSIFGCREKML---RNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQEL--QQMRETVLELESRLVRQDHKLRELSIRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNAPRCSNYISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQHHVEVMETKPDLQA---FQRPTVQRNPKGFGYVTFMQLQAL-HQRGFVRDDVLMVRCEV 496
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf2a (TNF receptor-associated factor 2-like [Source:NCBI gene;Acc:103036375])

HSP 1 Score: 106.301 bits (264), Expect = 5.823e-24
Identity = 91/379 (24.01%), Postives = 159/379 (41.95%), Query Frame = 2 
Query:  434 HISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCI----------------------DNLNNEMNEIKIIVGNFKGQFDKNTN------------------DQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNII---SDNFRNYPNRLDTLNR-NSTNPINLTAVSNKIDDAMK-FGLTKLA--DMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            HI  C      C +  +GC+ S V   K+ DH R   + H  LL+  I                        L+  + E+++ +G                               +  A +E +L  +  ++  L +R   LE         LK  +  NI+   +         ++  NR +  +   +  ++NK+    +  GL  L+  +ME  ++ M +      FVWK+  F+ K + A  G+  ++FS +FYT +YGYKMCL+++ NG+      +LS+F  +M+   D +L+WPF    T  L++Q  R   +   R   +  +FQ      +P+ + N+  G   F  L +L + + + R+D IFIK  V
Sbjct:  205 HIKLCTKFRTPCRFHVVGCDMS-VEKEKIHDHERACSYEHLNLLLHFIMGIKVNLESLQPQSLELASHKIQELHQSLRELELKMGQLSAGAPVQGACAPPPPPPPTLATSFTPLPTTVGAALELQLHSEKTKVAELSRRCQELE---------LKVGTFENIVCVLNREMERSATTMEAYNRQHRLDQDKIEILNNKVRQLERTVGLRDLSIVEMEGKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQNNREHIIDAFRPDISSSSFQ------RPVSDMNIASGCPLFCPLSKLDSKNSYIRDDTIFIKAIV 567
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf2a (TNF receptor-associated factor 2-like [Source:NCBI gene;Acc:103036375])

HSP 1 Score: 102.834 bits (255), Expect = 4.502e-23
Identity = 92/358 (25.70%), Postives = 161/358 (44.97%), Query Frame = 2 
Query:  380 KCPENS--CDYVDE---LRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCID-NLNNEMNEIKIIVGNFKGQFDKNTN--DQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMK-FGLTKLA--DMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            +CPE +  C Y  E    + I+ H   C    +IC     GC +  +   K  DH++      T      +  +++    +  +I+      +   T    Q+  AE+  + Q+       L+ +V   EN+  V    L  E   +  +    N  +RLD           +  ++NK+    +  GL  L+  +ME  ++ M +      FVWK+  F+ K + A  G+  ++FS +FYT +YGYKMCL+++ NG+      +LS+F  +M+   D +L+WPF    T  L++Q  R   +   R   +  +FQ      +P+ + N+  G   F  L +L + + + R+D IFIK
Sbjct:  123 ECPERTLNCKYCKEPFHFKNIKAHDEICPKYPMICE----GCAKKKIPREKYVDHIKLCTKFRTPCRFHVVGCDMSVSKPQWNLILTPRDLLYTSFTVPLSQTKVAELSRRCQE-------LELKVGTFENIVCV----LNREMERSATTMEAYNRQHRLDQ--------DKIEILNNKVRQLERTVGLRDLSIVEMEGKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQNNREHIIDAFRPDISSSSFQ------RPVSDMNIASGCPLFCPLSKLDSKNSYIRDDTIFIK 451
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002130.1 (pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 gene:ENSPMAG00000001936.1 transcript:ENSPMAT00000002130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 112.849 bits (281), Expect = 2.632e-27
Identity = 89/404 (22.03%), Postives = 172/404 (42.57%), Query Frame = 2 
Query:  257 LNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTN--------------DQSYWAEIE-SKLQQQTMEIDLLKQRVHNLENLDFVDR-PKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDD--AMKFGLTKLADMEVNLKRMKSF--EFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            L      CP   + CK    ++  ++ ++R    + ++  + CP N  ++     ++  H+S C   T +C +  +GC     +   + +H  + + +H  L++       +  +E+++     +   + +TN              D S+W+ +  S   +    +++L Q    L++L    R P+  A++    +  +      RL  L     NP       +  +    M  GL   A+  + +     +  + VWK+  +  + + A  G+TLS++S  FYT  +GYKMC + + NG+      +LS+F  +M+ + D +LEWPFR   T SL++Q     H   T T D         +P  + NV  G   F+    L     +  +D +F++  V
Sbjct:   22 LAAHRASCPHRAEFCKYCSAAVTCSL-LERHHKEECAQYPLPCPNNCEEHGIPRAELSQHMSACAMSTKLCGFHMLGCTFKQGTSESVREHEESAVRSHFTLVI-------SRNSELELQCARLQCSIEDHTNMSEMLTQRVAQLEQDLSHWSTLTGSNNTRLGSTLEMLTQHNEQLQSLHVAQRAPQRDADT--AALRRDMATLRERLRALEAALGNPGPCEERCHMHEQRLTMHDGLLDTAERRLQVLETAGYSGKLVWKIRDYARRKQEAASGRTLSLYSQPFYTSPFGYKMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLEWPFRRRVTLSLLDQGAARRHLSDTFTPD--PASGSFRRPDGDMNVASGCPLFVSHVAL-EGSSYLVDDTVFVRVVV 412
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000074.1 (pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-1 gene:ENSPMAG00000000066.1 transcript:ENSPMAT00000000074.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 96.2857 bits (238), Expect = 1.712e-21
Identity = 53/193 (27.46%), Postives = 99/193 (51.30%), Query Frame = 2 
Query:  851 NSTNPINLTAVSNKID--DAMKFGL-TKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            +S+ P  L A+ + +   D   F   T+LA+M++  + +++  +    VWK+  +  + + A  G+TLS++S  FYT  +GY+MC + + NG+      +LS+F  +M+ + D +L WPFR   T +L++Q       + + T+          +P  + N+  G   F+    L  +  + ++D IFIK  V
Sbjct:  280 HSSTPTRLAALDSALSRHDTQLFAHDTRLAEMDLRFQVLETASYNGKLVWKIRDYARRKQDAVSGRTLSLYSQPFYTSPFGYRMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLPWPFRQRVTLTLLDQGA--ARRQLSDTFKPDPASSSFRRPTSDMNIASGCPLFVSHVAL-ESASYLQDDTIFIKVVV 469
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 69.3218 bits (168), Expect = 9.367e-13
Identity = 51/218 (23.39%), Postives = 101/218 (46.33%), Query Frame = 2 
Query:  827 NRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLS----------IFSDSFYTHQYGYKMCLQL-------FPNGNAEYA------NNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNV-GYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            +++  L+  + N   L A + ++  +++    ++A+ E    R+ +  F W+V++F+  +         S          + S  FYT   GY++CL+L        P G A  +        +L++F+ L++ D D  L WPF+     S+++Q  R      T   D         +P + RN  G+GY++FMD+  L ++  + R+D + ++ +V
Sbjct:  353 HQIRELSAKTDNQQGLLAEATRLVRSLE---ARVAESE---SRLCAGIFTWRVERFSRLLPGGLASGFASDGMHPDAPAVMHSSGFYTGVPGYRLCLRLQVLSGREVPAGAASPSVLLAGRQPHLALFVHLLQGDYDHRLPWPFKGRIRISVVDQCER-DSVHVTEMMDADPQLSAFQRPSVHRNPKGFGYMNFMDINTL-HHRSYLRDDCLVVRCEV 562
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO35237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM27])

HSP 1 Score: 123.25 bits (308), Expect = 4.458e-30
Identity = 95/374 (25.40%), Postives = 166/374 (44.39%), Query Frame = 2 
Query:  359 KISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQ---FDKNTNDQSY-WAEIESKLQQQTMEIDLLKQRVHNL-------------ENLDFVDRPKLKAESLNNIISDN---FRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKL--ADMEVNLKRMKSFE--FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            K     I+CP        E +K+  H  +C +    C +  +GC    V    + +H    +  H  LL          + E++  +  F G+   F        Y +A+++ +   Q   + ++++ V N              ENL    R + K +        N     +   RL+  + + TNP  L    ++++ ++    TKL   D+ + +++  S++  F+WK+DKF ++   AK G   SI+S  FYTH++GYK+C +LFPNG+    +NYLS+F+ LM+ + D IL WPF+   T +LI+Q   +  S    T+D         +P    NV  G   F   + +     +   + +F+K  V
Sbjct:  155 KCPAFPIECPNECGVKRIERKKLSAHTRECPNALTDCRFSPLGCT-YKVKKIALREHQNKHVIKHMILLGRTTGEPQPNLLELENQLERFDGENTSFKTELERHKYEFAQMKERFNDQNARLGIVEKTVANQKGDIAEIWMRFDQENLVGEVRMRDKLKKFKVKTKANKECLLSLMKRLEVQDDSQTNPNKLNRRLSQLESSITIHKTKLFQEDLRIQIQQAISYDGTFLWKIDKFTERYAEAKSGNATSIYSSPFYTHRFGYKLCARLFPNGDGSARDNYLSIFIALMRGEYDSILPWPFQETITITLIDQDNGMNISE---TFDPDPCSISFQRPTRNINVASGCPRFCS-QTVLRTRGYMNENCVFVKVVV 523
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJK8])

HSP 1 Score: 112.464 bits (280), Expect = 1.259e-26
Identity = 124/479 (25.89%), Postives = 211/479 (44.05%), Query Frame = 2 
Query:  164 DMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENL-CPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKL----LMDCID-NLNNEMNEIKII-----------------VG-NFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNL-ENLDFVDRPKLKAESLNNIISDN---------FRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMK--FGLT---------KLADMEVNLK-RMKSFEFVWKVDKFNDKMKAA---------KKGKTLS----------IFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEK--CLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIK 1399
            ++IC +C  V+       CG  +C  CI  + NG+E + CP + +  K         I  D+  +  +  L +KC  N C +  ELR+ + H+  C+ + + C  I  GCN       K+P  L   +  HT      L+ C   NL+    + + +                 +G  FKG+  ++  D+   + +++ L      I   K+++ +L + LD V R +L+ +S +++   N          R+   +++ L++      N    + +  D +K   G+          ++A +    K +     FVW++  + DK K A         K G + S          + S  FYT +YGYKM L+ +PNG  +    +LS+ + +MK + D ILEWPFR   T SLINQ  +          D+   +K    ++PI   NVG GY  F+   EL N+ D+ ++D IFI+
Sbjct:   27 ELICAICHMVVNEPVLTSCGHSYCKYCIEKWCNGKEVVTCPVDNEQLK------PSQIFPDKKTDRIVLSLEVKCTNNPCRWKGELRQKQKHLKICSHKAVKC--ILEGCNV------KVPRIL---MEKHTNTCGWRLLHCKPCNLSYPKKDEETVQHKDDCPLAFLPCRFSEIGCTFKGR--ESARDEHCESAVQTHLHIACETIRDNKEQISDLHKELDKV-RQELQTKSCDHMKEVNAIREKHDEAIRDNKGQIEALSKEHGIASNTIHENKEQLDTLKKELGIASETIRKNRDQIAKLSTACKTQYTDGTFVWRICNYKDKYKKAVAFATNQEVKGGNSDSDDDISMAGDIMVSLPFYTSRYGYKMRLKAYPNGYGDGKGTHLSLSIRIMKGEYDAILEWPFRRKITLSLINQSEQWRSETVEIYPDDATPDKKHKFERPIENENVGCGYSCFISHMEL-NSGDYIKDDVIFIE 484
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO49464 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG36])

HSP 1 Score: 109.383 bits (272), Expect = 1.678e-25
Identity = 87/374 (23.26%), Postives = 162/374 (43.32%), Query Frame = 2 
Query:  377 IKCPENSCDYV--DELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDK---------------NTNDQSYWAE---IESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQ---MEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSS 1417
            + CP    + +  DEL   + +I  C    + C + K GC+        +  H R+    H  LL+    N     +E+   +   + +  K               N N ++Y  +   IE  + +Q  E+  LK+R+  L+ ++   R + +   L  I ++  R         +   T  + L    ++ +  +     +LA+ ++ L+ +++  +    +WK+D++  + +    GKT SI+S  FY  +YGYK C +++PNG+     ++LS+F  LM+ + D +L WPFR   TF L++Q       R     D F+         +P    N+  G   F+    L     + R+D +FIK  V ++
Sbjct:  166 VVCPHCGAEGICRDELLHHQTNI--CEQAELPCSFAKHGCHFKGTREA-LETHFRDQASVHVNLLLTATQNEEKARSEMAAKLSQMEKERAKQQEQMYEQREALAVANQNLRTYQGKLNVIERSVAEQRRELAELKERI-QLQEVEAAIREQDR--RLGMIENEASRGAAPSSGPGSMGGT--MALERRQDRNEHQLALHDIQLAEHDLKLQMLEATSYDGTYIWKIDEYTRRYQEGVSGKTPSIYSPPFYVGRYGYKACARVYPNGDGMGKGSHLSLFFVLMRGEFDALLPWPFRQKVTFKLLDQ------DRVHDIGDTFRPDPTSSSFKRPTSNMNIASGCPLFISHTNL-QTRAYVRDDTMFIKIAVDTT 524
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO38873 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBN4])

HSP 1 Score: 103.219 bits (256), Expect = 1.360e-23
Identity = 116/493 (23.53%), Postives = 209/493 (42.39%), Query Frame = 2 
Query:  125 MENYDFSGVE--VDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNL-----------------------NNEMNEIKIIVGNF-------KGQFDKNTND--QSYWAEIESKLQQ----------QTMEI----------DLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLA--DMEVNLKRMKSFEF----VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQ---RTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M  Y+ +  +  + +  +C  C  ++ ++    CG R+C  CIS  L+     C    D C   +   E     D+  + +I  L + C    + C +  ELR  + H ++C    I C + + G     +S+ K+P+HL+N+     +    C   +                       + E+  +++    F       KG+  +NT +  + + + I+ KL+Q          Q+M I          D+L+ RV N+E     D   L  E+ + +  D  R    RL+   + S + I       ++ D    GL  LA  D+E  L  ++   F    +WK+    +K   A  G+  S +S  F+T  +GYKMC +++ NG+    N+++S+F  +M+ + D +L WPFR   T  L++Q      +   R   +  +FQ      +P  E N+  G   F   ++L  +  + R+D +F+K  V
Sbjct:    6 MVGYEIATTDTAIAAKHLCAKCRLIVKDAVQTACGHRYCSPCISPLLSRGPIQC----DVCGSTITKPE--TFRDKFADREILELHVHCVNQPHGCPWEGELRHRQNHHTKCEFNPISCVHPECG---KKLSVAKLPEHLQNECQYREETCSYCEQPVVVARMKEHHEKTCPSYPVNCPKCSKELIRVEVHSTPFTREPRLEKGRGCENTLEVLEDHESRIK-KLEQRGGGIGVNGLQSMRISENIDNEAIGDVLR-RVANVE-AKGADHEVLVVEAHSAV--DELRREVGRLNVKLQESDDIIRRLERQLELHD-QGTGLRNLAIADLEERLNTLQGTTFDSVLLWKITNVANKRSEATSGRVTSFYSPCFFTGPHGYKMCARIYLNGDGMGRNHHVSLFFVIMRGEFDALLRWPFRQKVTLMLLDQDNVEHVIDAFRPDPSSSSFQ------RPRAEMNIASGCPLFCSHEQLTQH-AYIRDDTMFLKIIV 476
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48773 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI91])

HSP 1 Score: 98.9821 bits (245), Expect = 3.552e-22
Identity = 57/195 (29.23%), Postives = 97/195 (49.74%), Query Frame = 2 
Query:  872 LTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFE-----------FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRSTTTYDNFQMEKCLDKPILERN-VGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            L  +  K++D       ++A++   L R+++ E           F+WK+D F    + +  G T +I S  FYT  YGYKMCL++  NG       ++S+F+ +M+ D D ILEWPF    T S+++Q     +R P S +     N        +P   RN  GYGY++F  + +L     + +N+ I ++ ++
Sbjct:  290 LAYLERKVEDVKTSSDRRIAELTHKLMRLETREIELEGRVCNGTFIWKLDNFRQCREGSIAGLTAAIHSPPFYTSMYGYKMCLRMNLNGVDGGLGEHVSLFIHMMQGDWDGILEWPFIGRITLSILDQSDQIDSRRPISETLVAKPNLLA---FQRPTSPRNHKGYGYVEFCPIDQL-TEGQYIKNNSILVRIQI 480
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 119.398 bits (298), Expect = 2.311e-28
Identity = 88/333 (26.43%), Postives = 157/333 (47.15%), Query Frame = 2 
Query:  434 HISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLN-RNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            H   C      CP+ ++GC +S V  GK+ +H  +    H +LL+  + ++     +      +  G++ +++    Y A  +      ++    L ++V  LEN+  V    L  E   + ++    ++ +RLD     N +N I     S  + D       +L++ E  ++ ++       FVWK+  F+ + + A  G+  ++FS +FY+ +YGYKMCL+L+ NG+      +LS+F  +M+S  D +L+WPF    T  L++Q  R   +   R   T  +FQ      +P+ E N+  G   F  L +L     + R+D IFIK  V
Sbjct:  201 HAKSCAKSKSACPFSEVGC-KSVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDT-----SPSGEWQEDSGLGLYRAPDDGCGAAASVPSVDLDKKVSALENIVCV----LNREVERSSLTLEAFSHQHRLDQEKIENLSNKIRQLERSLTVKD------LQLSEAEQMVRELQYCTYDGIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQNNREHIIDAFRPDITSTSFQ------RPVSEMNIASGCPLFCPLAKLAGKSPYLRDDTIFIKAIV 511
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 119.398 bits (298), Expect = 2.331e-28
Identity = 88/333 (26.43%), Postives = 157/333 (47.15%), Query Frame = 2 
Query:  434 HISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLN-RNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFE----FVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTR---LPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            H   C      CP+ ++GC +S V  GK+ +H  +    H +LL+  + ++     +      +  G++ +++    Y A  +      ++    L ++V  LEN+  V    L  E   + ++    ++ +RLD     N +N I     S  + D       +L++ E  ++ ++       FVWK+  F+ + + A  G+  ++FS +FY+ +YGYKMCL+L+ NG+      +LS+F  +M+S  D +L+WPF    T  L++Q  R   +   R   T  +FQ      +P+ E N+  G   F  L +L     + R+D IFIK  V
Sbjct:  208 HAKSCAKSKSACPFSEVGC-KSVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDT-----SPSGEWQEDSGLGLYRAPDDGCGAAASVPSVDLDKKVSALENIVCV----LNREVERSSLTLEAFSHQHRLDQEKIENLSNKIRQLERSLTVKD------LQLSEAEQMVRELQYCTYDGIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQNNREHIIDAFRPDITSTSFQ------RPVSEMNIASGCPLFCPLAKLAGKSPYLRDDTIFIKAIV 518
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 117.857 bits (294), Expect = 4.308e-28
Identity = 113/476 (23.74%), Postives = 194/476 (40.76%), Query Frame = 2 
Query:  125 MENYDFSGVEVDSDMI-CGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTN---------DQSYWAEIESKLQQ-----QTMEIDLLKQRVHNLENLDF-----VDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M  +D+  +E       C LC K M      + CG RFC  C+  +L+     CP  +D   L+       I  D  +  +I  L I+C   E  C +  ++++++ H S C    I CP      N   V L +  +PDHL++D          C      E  E    V   +  + +N            Q   AE   + Q      +    D ++    +              P +  E L N + DN  +        +    +     A+   ++D  K  LT + ++ V+ +R +  E                +WK++ ++ K++ AK       FS  FYTH+YGYK+ +  F NGN     ++LSV++ ++  + D++LEWPF    TFS+++Q     ++  H   T      + NFQ        + E  +G+GY  F+  +E+    ++ R++ IFIK  +
Sbjct:    1 MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP--EDQLPLDYA----KIYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCP------NRCSVKLTRRDLPDHLQHDCPKRKVKCEFCGSEFTGEAFENHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGCKHRCPKLAIGRHLEDTTKSHLTMMCNL-VSRQRQEILELRREMEELSVSHDGVLIWKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQKPCSTRNSLDESTLGFGYPKFISHEEI-KKRNYIRDNCIFIKASI 462
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 117.857 bits (294), Expect = 5.353e-28
Identity = 117/498 (23.49%), Postives = 203/498 (40.76%), Query Frame = 2 
Query:  125 MENYDFSGVEVDSDMI-CGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTN---------DQSYWAEIESKLQQ-----QTMEIDLLKQRVHNLENLDF-----VDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL*LNFVIELNFIYFYLKIK 1474
            M  +D+  +E       C LC K M      + CG RFC  C+  +L+     CP  +D   L+       I  D  +  +I  L I+C   E  C +  ++++++ H S C    I CP      N   V L +  +PDHL++D          C      E  E    V   +  + +N            Q   AE   + Q      +    D ++    +              P +  E L N + DN  +        +    +     A+   ++D  K  LT + ++ V+ +R +  E                +WK++ ++ K++ AK       FS  FYTH+YGYK+ +  F NGN     ++LSV++ ++  + D++LEWPF    TFS+++Q     ++  H   T      + NFQ        + E  +G+GY  F+  +E+    ++ R++ IFIK  +     +  +++  FI  Y K +
Sbjct:    1 MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP--EDQLPLDYA----KIYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCP------NRCSVKLTRRDLPDHLQHDCPKRKVKCEFCGSEFTGEAFENHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGCKHRCPKLAIGRHLEDTTKSHLTMMCNL-VSRQRQEILELRREMEELSVSHDGVLIWKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQKPCSTRNSLDESTLGFGYPKFISHEEI-KKRNYIRDNCIFIKASIEIPQKIMVILKC-FIKLYGKPR 483
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 112.079 bits (279), Expect = 3.278e-26
Identity = 107/459 (23.31%), Postives = 184/459 (40.09%), Query Frame = 2 
Query:  173 CGLCGKVMINS-HNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKC--PENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGK--MPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTN---------DQSYWAEIESKLQQ-----QTMEIDLLKQRVHNLENLDF-----VDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEF---------------VWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQR----TRLPHSRST----TTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            C LC K M      + CG RFC  C+  +L+                 + L   I  D  +  +I  L I+C   E  C +  ++++++ H S C    I CP      N   V L +  +PDHL++D          C      E  E    V   +  + +N            Q   AE   + Q      +    D ++    +              P +  E L N + DN  +        +    +     A+   ++D  K  LT + ++ V+ +R +  E                +WK++ ++ K++ AK       FS  FYTH+YGYK+ +  F NGN     ++LSV++ ++  + D++LEWPF    TFS+++Q     ++  H   T      + NFQ        + E  +G+GY  F+  +E+    ++ R++ IFIK  +
Sbjct:   18 CPLCSKAMREPVQVSTCGHRFCDTCLQEFLS-------------IFFPMGLLPQIYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCP------NRCSVKLTRRDLPDHLQHDCPKRKVKCEFCGSEFTGEAFENHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGCKHRCPKLAIGRHLEDTTKSHLTMMCNL-VSRQRQEILELRREMEELSVSHDGVLIWKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQKPCSTRNSLDESTLGFGYPKFISHEEI-KKRNYIRDNCIFIKASI 455
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000020135.1 (SMESG000020135.1)

HSP 1 Score: 909.442 bits (2349), Expect = 0.000e+0
Identity = 442/444 (99.55%), Postives = 443/444 (99.77%), Query Frame = 2 
Query:   89 MAKFKFENIWKIMENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL 1420
            MAKFKFENIWKIMENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSY AEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADME+NLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL
Sbjct:    1 MAKFKFENIWKIMENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYLAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEINLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL 444
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000020135.1 (SMESG000020135.1)

HSP 1 Score: 885.174 bits (2286), Expect = 0.000e+0
Identity = 430/432 (99.54%), Postives = 431/432 (99.77%), Query Frame = 2 
Query:  125 MENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL 1420
            MENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSY AEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADME+NLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL
Sbjct:    1 MENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYLAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEINLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL 432
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000025794.1 (SMESG000025794.1)

HSP 1 Score: 352.829 bits (904), Expect = 1.012e-116
Identity = 191/452 (42.26%), Postives = 277/452 (61.28%), Query Frame = 2 
Query:   89 MAKFKFENIWKIMENYDFSGV-EVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTND-----------QSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M+  K EN+W+IM +Y++  V E+ +DM+C LC K+++N+  APCGCRFC  CIS++L+ +E +CPG+ ++CK E++ L ENI +D PMN KIS+L +KC E SC YVDELRK+E H   C  +++ CPY  IGC++ ++S  K+ DHL+++I  HTKLLMD + N NNEM  +K          +   N+           +   A+++ K   Q  EI+LL + +  L N+D     +L  + L  II  N +   +++  +   +   ++LT +SNKID        KL +M  N  +  + EF+WK+DKF DKM  AK G    I+S+SF TH+ G+KMCL++ P+GN      +LSVF  LMK + D ILEWPFR+  TF+LINQRTRLPH   T    N+  +K L +P  +RN G G+  F+  +EL +N D  RN+QIFIK  V
Sbjct:    1 MSGSKLENVWQIMRDYNYESVTEIQNDMLCFLCKKLLVNARCAPCGCRFCFTCISDFLDHKEKICPGDTEECKQEMLHLNENICVDYPMNIKISKLQVKCKEMSCVYVDELRKMEDHSRTCKYRSVACPYSNIGCDKCNISQDKVTDHLQSEIFAHTKLLMDFVVNFNNEMEMLKANNNGLSAVNELLRNEINELKLDGERRRVEIADLQRKCADQAEEIELLNEDIPALRNVDRNVSDRL--DGLQLIIEGNQKELIDKIGQM--ENKQKVDLTEMSNKIDKLSGNVDRKLLEMAANQNQRINGEFMWKLDKFTDKMADAKNGINTRIYSESFLTHKNGFKMCLRVDPDGNGGGKGTHLSVFFHLMKGEFDGILEWPFRHSVTFALINQRTRLPHVSKTVKCANYPNDKALIQPT-DRNAGLGFPKFVSHEELSSNPDLMRNNQIFIKCSV 447
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000025998.1 (SMESG000025998.1)

HSP 1 Score: 335.88 bits (860), Expect = 3.983e-110
Identity = 190/452 (42.04%), Postives = 272/452 (60.18%), Query Frame = 2 
Query:   89 MAKFKFENIWKIMENYDFSGV-EVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTND-----------QSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M+  K EN+ +IM +Y++  V E+ +DM+C LC K+++N+  APC CRFC  CIS++L+ ++  CPGN ++CK E++ L ENI +D PMN KI++L +KC E SCDYVDELRK+E H   C  +++ CPY  IGCN+ ++S  K+ DHL ++I  HTKLLMD + N +NEM  +K          +   N+           +   AE++ K   Q  EI+LL + +  L N+D     +L  + L  II  N +   +++  +   +   ++LT +SNKID        KL +M  N  +  + EFVWK+DKF DKM  AK G    I+S+SF TH+ GYKMCL + P+GN      +LSVF CLMK + D ILEWPF +  TF+LINQRTRLPH   T    ++   K   +P  +RN G+GY  F+  +EL +N D  RN++IFIK  V
Sbjct:    1 MSGSKLENVGQIMRDYNYESVTEIQNDMLCLLCKKLLVNARCAPCSCRFCFTCISDFLDHKKKNCPGNTEECKQEMLHLNENICVDYPMNMKIAKLQVKCKEKSCDYVDELRKMEDHSQTCKYRSVACPYSNIGCNKCNISQDKVADHLLSEILAHTKLLMDFVVNFHNEMEMLKANNNGLSAVNELLRNEINELKLDGERRREEIAELQKKCADQAEEIELLNEDIPALRNVDRNVSDRL--DGLQLIIEGNQKELIDKIGQM--ENKQKVDLTEMSNKIDKLSGNVDRKLLEMAANQNQRINGEFVWKLDKFTDKMADAKNGTNAIIYSESFLTHKNGYKMCLLVDPDGNGGGKGTHLSVFFCLMKGEFDGILEWPFGHSVTFALINQRTRLPHVSGTAKRSDYINNKAFIQPT-DRNAGWGYAKFVSHEELSSNPDLMRNNEIFIKCSV 447
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000025982.1 (SMESG000025982.1)

HSP 1 Score: 329.717 bits (844), Expect = 8.092e-108
Identity = 191/455 (41.98%), Postives = 275/455 (60.44%), Query Frame = 2 
Query:   89 MAKFKFENIWKIMENYDFSGV-EVDSDMICGLCGKVMINSHNAPCGCRFCLDCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCPENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRNDIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNT--------------NDQSYWAEIESKLQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLDTLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVDKFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSVFLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCLDKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKV 1408
            M+  K EN+ +IM +Y++  V E+ +DM+C LC K+++N+  APC CRFC  CIS++L+ ++  CPGN ++CK E++ L ENI +D PMN KI++L +KC E SCDYVDELRK+E H   C  +++ CPY  IGC++ ++S  K+ DHL+++I  HTKLLMD + N NNEM   +I+  N  G    N                 +    +++ K   Q  EI+LL + +  L N+D     +L  + L  II  N +   +++  +   +   ++LT +SNKID        KL +M  N  +  + EFVWK+DKF DKM  AKKG    I+S+SF TH+ G+KMCL ++P+G+     N+LSVF  LMK + D ILEWPFR+  TF+LINQRTRLPH    T   N+   K   +P  +RN G G+  F+  +EL +N D  RN+QIFIK  V
Sbjct:    1 MSGSKLENVGQIMRDYNYESVTEIQNDMLCLLCKKLLVNARCAPCSCRFCFTCISDFLDHKKKNCPGNTEECKQEMLHLNENICVDYPMNMKIAKLQVKCKEMSCDYVDELRKMEDHSRTCKYRSVACPYSNIGCDKCNISQDKVTDHLQSEIFVHTKLLMDFVVNFNNEM---EILKANNNGLSPVNELLRNEINELKLDGDRRRVEIGDLQRKCANQAEEIELLNEDIPALRNVDRNVSDRL--DGLQLIIEGNQKELIDKIGQM--ENKQKVDLTEMSNKIDKLSGNVDRKLLEMAANQNQRINGEFVWKLDKFTDKMADAKKGINAFIYSESFLTHKNGFKMCLSVYPDGDGGGKGNHLSVFFHLMKGEFDGILEWPFRHSVTFALINQRTRLPHVSKITECANYPNNKEFIQPT-DRNAGRGFARFVSHEELSSNPDLMRNNQIFIKCSV 447
The following BLAST results are available for this feature:
BLAST of TNF receptor-associated factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRAF42.845e-2722.25TNF receptor associated factor 4 [Source:HGNC Symb... [more]
TRAF23.129e-2622.02TNF receptor associated factor 2 [Source:HGNC Symb... [more]
TRAF31.194e-2423.73TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF32.749e-2423.24TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF32.749e-2423.24TNF receptor associated factor 3 [Source:HGNC Symb... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
trf-11.889e-2032.94TNF Receptor Associated Factor (TRAF) homolog; TRF... [more]
trf-22.037e-2035.56TNF Receptor Associated Factor (TRAF) homolog [So... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Traf42.710e-1826.46gene:FBgn0026319 transcript:FBtr0077429[more]
Traf42.820e-1826.46gene:FBgn0026319 transcript:FBtr0334401[more]
Traf65.488e-623.68gene:FBgn0265464 transcript:FBtr0071188[more]
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BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf37.230e-2623.80TNF receptor-associated factor 3 [Source:ZFIN;Acc:... [more]
traf2b1.495e-2525.29Tnf receptor-associated factor 2b [Source:ZFIN;Acc... [more]
traf2b1.495e-2525.29Tnf receptor-associated factor 2b [Source:ZFIN;Acc... [more]
traf2b2.220e-2525.29Tnf receptor-associated factor 2b [Source:ZFIN;Acc... [more]
traf4a3.546e-2522.34tnf receptor-associated factor 4a [Source:ZFIN;Acc... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ssh23.543e-2623.57slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
ssh22.526e-2522.59slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
TRAF26.748e-2422.87TNF receptor associated factor 2 [Source:NCBI gene... [more]
TRAF27.576e-2423.69TNF receptor associated factor 2 [Source:NCBI gene... [more]
slc12a12.073e-2024.59solute carrier family 12 member 1 [Source:Xenbase;... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Traf41.614e-2822.45TNF receptor associated factor 4 [Source:MGI Symbo... [more]
Traf21.119e-2626.27TNF receptor-associated factor 2 [Source:MGI Symbo... [more]
Traf21.218e-2626.19TNF receptor-associated factor 2 [Source:MGI Symbo... [more]
Traf11.838e-2425.72TNF receptor-associated factor 1 [Source:MGI Symbo... [more]
Traf11.838e-2425.72TNF receptor-associated factor 1 [Source:MGI Symbo... [more]
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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P39429|TRAF2_MOUSE8.519e-2626.19TNF receptor-associated factor 2 OS=Mus musculus O... [more]
sp|Q12933|TRAF2_HUMAN1.503e-2522.02TNF receptor-associated factor 2 OS=Homo sapiens O... [more]
sp|P39428|TRAF1_MOUSE1.286e-2325.72TNF receptor-associated factor 1 OS=Mus musculus O... [more]
sp|Q13114|TRAF3_HUMAN1.320e-2323.24TNF receptor-associated factor 3 OS=Homo sapiens O... [more]
sp|Q60803|TRAF3_MOUSE1.790e-2324.15TNF receptor-associated factor 3 OS=Mus musculus O... [more]
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BLAST of TNF receptor-associated factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1E1015.254e-4727.53TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
A0A2B4SJ657.980e-3426.80TNF receptor-associated factor 4 OS=Stylophora pis... [more]
A0A5K4F9L51.867e-3326.62Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A3L7HD981.889e-3325.51TNF receptor-associated factor OS=Cricetulus grise... [more]
A0A5K4F8V44.787e-3325.87Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf2b2.801e-2524.78TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf4a2.977e-2522.27TNF receptor associated factor 4 [Source:NCBI gene... [more]
traf69.714e-2522.10TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf2a5.823e-2424.01TNF receptor-associated factor 2-like [Source:NCBI... [more]
traf2a4.502e-2325.70TNF receptor-associated factor 2-like [Source:NCBI... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000002130.12.632e-2722.03pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 g... [more]
ENSPMAT00000000074.11.712e-2127.46pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-... [more]
traf69.367e-1323.39TNF receptor-associated factor 6 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO352374.458e-3025.40Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483941.259e-2625.89Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO494641.678e-2523.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO388731.360e-2323.53Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO487733.552e-2229.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf2b2.311e-2826.43TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf2b2.331e-2826.43TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf4a4.308e-2823.74TNF receptor associated factor 4 [Source:NCBI gene... [more]
traf4a5.353e-2823.49TNF receptor associated factor 4 [Source:NCBI gene... [more]
traf4a3.278e-2623.31TNF receptor associated factor 4 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000020135.10.000e+099.55SMESG000020135.1[more]
SMESG000020135.10.000e+099.54SMESG000020135.1[more]
SMESG000025794.11.012e-11642.26SMESG000025794.1[more]
SMESG000025998.13.983e-11042.04SMESG000025998.1[more]
SMESG000025982.18.092e-10841.98SMESG000025982.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034560 ID=SMED30034560|Name=TNF receptor-associated factor|organism=Schmidtea mediterranea sexual|type=transcript|length=1591bp
CTAACTTTCAAATAAATTGCACAATTAAATAAATTATAGGCTAATCCAAC
CAGTCAATAAAATCCAATTTTCAGACTAATTTATAAAAATGGCTAAATTT
AAATTTGAAAATATTTGGAAGATTATGGAAAATTATGATTTTTCCGGAGT
CGAAGTCGACAGCGACATGATATGTGGATTGTGTGGCAAAGTTATGATTA
ATTCCCACAATGCTCCGTGTGGTTGCAGGTTTTGTTTGGATTGCATTTCG
AATTATTTGAACGGAAGAGAAAATTTGTGCCCCGGAAATAAAGACGATTG
CAAATTGGAATTGATTAGCCTAGAGGAGAACATTGCAATAGATCGACCGA
TGAATAACAAAATATCGAGATTAATAATAAAATGTCCGGAAAACTCATGC
GATTATGTAGATGAATTGAGAAAAATAGAATTGCACATAAGTCAGTGCAA
TAGTCAAACAATAATTTGTCCATATATCAAAATTGGGTGCAACGAATCTG
ACGTGTCATTAGGTAAAATGCCGGACCATTTGCGCAACGATATCCATAAC
CACACAAAACTACTGATGGATTGTATTGATAATTTAAACAATGAAATGAA
TGAGATAAAAATAATTGTTGGTAACTTTAAAGGACAATTTGATAAAAATA
CGAATGATCAATCATATTGGGCAGAAATCGAATCGAAATTACAACAGCAA
ACAATGGAAATCGATCTATTAAAACAACGAGTTCATAATTTGGAGAATTT
AGATTTCGTTGATAGACCCAAATTGAAAGCGGAAAGTCTAAATAATATAA
TCAGCGATAATTTCAGAAACTATCCAAATAGATTGGATACATTAAATAGA
AATTCAACCAATCCGATCAATTTGACAGCCGTCTCCAATAAGATTGATGA
TGCAATGAAATTCGGCTTGACTAAATTGGCCGATATGGAAGTCAACTTGA
AACGAATGAAAAGCTTTGAATTTGTATGGAAAGTCGATAAATTCAATGAT
AAAATGAAAGCTGCGAAAAAAGGCAAGACGTTATCGATTTTCAGCGATTC
ATTTTATACTCACCAATATGGATACAAAATGTGTCTGCAATTGTTTCCGA
ATGGAAATGCTGAATATGCCAATAATTATTTATCTGTTTTTCTCTGTTTA
ATGAAAAGTGATTTGGATGACATTTTGGAATGGCCATTCAGAAATCACTT
CACATTCTCATTGATTAATCAACGGACTCGACTTCCGCATTCAAGATCTA
CAACGACTTACGATAACTTTCAAATGGAGAAATGCCTTGACAAACCAATT
CTTGAAAGAAATGTGGGTTATGGATATTTGGATTTTATGGATTTAAAAGA
GCTATTCAATAACGACGACTGGACGAGAAACGATCAGATATTCATAAAAT
TTAAAGTTCATTCTTCTTTATAATTAAATTTTGTTATTGAATTAAATTTT
ATTTATTTTTATTTGAAAATTAAAATCGATTGATTCGATACCTAGTTTAA
ATGGACTTTGATTTTTATAAATTGAAAAATGCAACTTTGTAAAAGTTTGA
CCTATGACCTCAAATAATGTTAAAAGAATCAATTAATAAAT
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protein sequence of SMED30034560-orf-1

>SMED30034560-orf-1 ID=SMED30034560-orf-1|Name=SMED30034560-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=445bp
MAKFKFENIWKIMENYDFSGVEVDSDMICGLCGKVMINSHNAPCGCRFCL
DCISNYLNGRENLCPGNKDDCKLELISLEENIAIDRPMNNKISRLIIKCP
ENSCDYVDELRKIELHISQCNSQTIICPYIKIGCNESDVSLGKMPDHLRN
DIHNHTKLLMDCIDNLNNEMNEIKIIVGNFKGQFDKNTNDQSYWAEIESK
LQQQTMEIDLLKQRVHNLENLDFVDRPKLKAESLNNIISDNFRNYPNRLD
TLNRNSTNPINLTAVSNKIDDAMKFGLTKLADMEVNLKRMKSFEFVWKVD
KFNDKMKAAKKGKTLSIFSDSFYTHQYGYKMCLQLFPNGNAEYANNYLSV
FLCLMKSDLDDILEWPFRNHFTFSLINQRTRLPHSRSTTTYDNFQMEKCL
DKPILERNVGYGYLDFMDLKELFNNDDWTRNDQIFIKFKVHSSL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0001817regulation of cytokine production
GO:0001878response to yeast
GO:0008063Toll signaling pathway
GO:0032088negative regulation of NF-kappaB transcription factor activity
GO:0033209tumor necrosis factor-mediated signaling pathway
GO:0042981regulation of apoptotic process
GO:0045087innate immune response
GO:0050688regulation of defense response to virus
GO:0006955immune response
GO:0007165signal transduction
GO:0016567protein ubiquitination
Vocabulary: molecular function
TermDefinition
GO:0005164tumor necrosis factor receptor binding
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0004842ubiquitin-protein transferase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR012227TNF_rcpt-assoc_TRAF_met
IPR043211TNF_rcpt-assoc_TRAF
IPR013083Znf_RING/FYVE/PHD
IPR002083MATH/TRAF_dom
IPR008974TRAF-like
IPR001841Znf_RING
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 194..221
NoneNo IPR availablePANTHERPTHR10131:SF127coord: 22..441
NoneNo IPR availableCDDcd16449RING-HCcoord: 29..65
e-value: 4.36834E-5
score: 38.6025
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 11..100
IPR002083MATH/TRAF domainSMARTSM00061math_3coord: 297..422
e-value: 1.1E-15
score: 68.1
IPR002083MATH/TRAF domainPROSITEPS50144MATHcoord: 292..440
score: 24.099
IPR012227TNF receptor-associated factor TRAF, metazoaPIRSFPIRSF015614TRAFcoord: 5..128
e-value: 1.9E-10
score: 37.7
coord: 109..444
e-value: 3.1E-54
score: 182.2
IPR008974TRAF-likeGENE3DG3DSA:2.60.210.10coord: 253..442
e-value: 2.6E-49
score: 169.4
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 293..441
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 95..155
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 11..130
e-value: 3.0E-13
score: 51.8
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 22..441
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 29..68
score: 8.934