Disrupted in renal carcinoma protein 2-like

Overview
NameDisrupted in renal carcinoma protein 2-like
Smed IDSMED30034544
Length (bp)1985
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Disrupted in renal carcinoma protein 2-like (SMED30034544) t-SNE clustered cells

Violin plots show distribution of expression levels for Disrupted in renal carcinoma protein 2-like (SMED30034544) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Disrupted in renal carcinoma protein 2-like (SMED30034544) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Disrupted in renal carcinoma protein 2-like (SMED30034544) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034544

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30034544h1SMcG0021072 Contig2590GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30034544h1SMcG0021072 Contig2590GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30034544h1SMcG0021072 Contig2590GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30034544h1SMcG0021072 dd_Smed_v4_4596_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30034544h1SMcG0021072 dd_Smed_v4_4596_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30034544h1SMcG0021072 dd_Smed_v4_4596_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Zebrafish
Match: slc49a4 (solute carrier family 49 member 4 [Source:ZFIN;Acc:ZDB-GENE-040912-167])

HSP 1 Score: 56.225 bits (134), Expect = 2.434e-16
Identity = 41/181 (22.65%), Postives = 85/181 (46.96%), Query Frame = 1 
Query:  415 TMESEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCK-YSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDN 954
            T  +  + +  +   RR+++L  F +  F  G++WN+W P+  S   ++ +S+T++ +L     +     +  F+ L +K G++ +   S+  ++LG  +R  P K    +  +I  G  ++          +  +S  WF   +R+ +T  A   S LGS  A ++G  + V   N+ + 
Sbjct:   22 TNTTSTQPVFSRVYGRRWFVLTMFSLLGFMQGLVWNTWGPIQNSAKHVFEFSSTDIAILVLWGPVGYLPWLL-FMWLMDKKGLRASLLLSAFFMVLGAALRSVPLKDLYYRRWMIHGGQLLNGLAGPTVMSAAPLLSTTWFAPDQRATATAIASLISYLGSACAFLIG-PLAVPAPNDTEK 200

HSP 2 Score: 49.2914 bits (116), Expect = 2.434e-16
Identity = 62/276 (22.46%), Postives = 111/276 (40.22%), Query Frame = 2 
Query: 1043 TPENKEKI---------HLGMQQFMFFHCSIALTTVLLIII--YFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATL--VSVGNLCVF------ISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNIS----FEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
             P + EK+         H+G +     +    +   L + +  YFPS+P  +P   +  S R+  +S    L  N +F +I L   + +G  +G   VL  I+ P  V+Q++   +   S+   CVF       +  I G+L      K I++L      +    F L  +  + H L    A L T   +  I  N S     E+  E  +P  E +T  V+ F +NL   ++L         ++W+ +    + +  L  +  +++   R   D
Sbjct:  194 APNDTEKLGNVIYWNQNHIGNRIQFVLYTEFGMIAALFVAVLFYFPSRPP-IPPSVAAASQRLSYRSSICRLLSNMRFLMIALAYSVPTGVAAGWAGVLDMILTPAKVSQVDAGWIGFWSIVGGCVFGVAMARFADYIRGML------KLILVLMFAGASLAATWFTLTCLTRLTH-LPSTKATLYTSCILVGIFINSSVPIFLELFIETVYPVPEGITCGVVTFLSNLFTGLLLFCLTFYFTELSWLNWCLTGSCIFSLLLLLLFRESYDRLYLD 461
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Xenopus
Match: kif13b (kinesin family member 13B [Source:Xenbase;Acc:XB-GENE-956968])

HSP 1 Score: 51.2174 bits (121), Expect = 3.859e-6
Identity = 58/233 (24.89%), Postives = 103/233 (44.21%), Query Frame = 2 
Query: 1130 IIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIG---GILGDKFS--YKKIVILSIPPTIVTYVLFGLQSMKIIRH---ELGVIY-AVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            I+ YF      +P   +  S R+  ++  + L  N +F +I L   I  GF +G   VL  I+ P+ VTQ++      VG   +    ++G   G   D      K I++L      ++   F L  +  + H       +Y + +L  +F+S  +  I FEM  E  +P  E +T  V+ F +NL + V+L    +   N++W+ +    +  L L F+  +++   R   D
Sbjct:  138 ILAYF-PSRPPVPPSVAAASRRLSYRTSILRLLSNVRFLLIVLAYAIPLGFYAGWSGVLDLILTPVHVTQVDAGW---VGFWSIVGGCVVGIAVGRFADSIRGVLKPILLLLFSGAALSSTWFTLTFLSNVTHLPLTTATLYTSCILIGVFLSGTVP-IFFEMFVETVYPIPEGITCGVVTFLSNLFMGVLLLFLTLYQTNLSWLNWCLTGSCFLSLLFIACFRESYDRLYLD 365
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Xenopus
Match: kif13b (kinesin family member 13B [Source:Xenbase;Acc:XB-GENE-956968])

HSP 1 Score: 50.8322 bits (120), Expect = 4.641e-6
Identity = 61/233 (26.18%), Postives = 107/233 (45.92%), Query Frame = 2 
Query: 1130 IIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIG---GILGDKFS--YKKIVILSIPPTIVTYVLFGLQSMKIIRH---ELGVIY-AVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            I+ YFPS+P   P  ++  S R+  ++  + L  N +F +I L   I  GF +G   VL  I+ P+ VTQ++      VG   +    ++G   G   D      K I++L      ++   F L  +  + H       +Y + +L  +F+S  +  I FEM  E  +P  E +T  V+ F +NL + V+L    +   N++W+ +    +  L L F+  +++   R   D
Sbjct:  135 ILAYFPSRPPVPPSVAA-ASRRLSYRTSILRLLSNVRFLLIVLAYAIPLGFYAGWSGVLDLILTPVHVTQVDAGW---VGFWSIVGGCVVGIAVGRFADSIRGVLKPILLLLFSGAALSSTWFTLTFLSNVTHLPLTTATLYTSCILIGVFLSGTVP-IFFEMFVETVYPIPEGITCGVVTFLSNLFMGVLLLFLTLYQTNLSWLNWCLTGSCFLSLLFIACFRESYDRLYLD 362
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. UniProt/SwissProt
Match: sp|Q6GNV7|DIRC2_XENLA (Solute carrier family 49 member 4 homolog OS=Xenopus laevis OX=8355 GN=slc49a4 PE=2 SV=1)

HSP 1 Score: 55.8398 bits (133), Expect = 7.676e-7
Identity = 41/153 (26.80%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  460 RRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCK-YSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVG 915
            RR+ +L  F + +F  G++WNSW P+  S    Y +S  ++ LL     I      F F+ L +  G++     ++ +++LG  +R  P +  +I+ I+I  G  ++ +        +  +S  WF   ER+ +T  A   + LG   A +VG
Sbjct:   28 RRWLVLLLFSVLAFLQGLVWNSWGPIQISARTAYKFSGLDIALLVLWGPIGFLP-CFLFMWLMDNRGLRITVLLTALLMVLGAGLRCVPVEDLAIRRILIHGGQLLNGFAGPTVMNAAPFLSTTWFAPDERATATAIASMLNYLGGACAFLVG 179
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. UniProt/SwissProt
Match: sp|Q9N1F2|FLVC1_FELCA (Feline leukemia virus subgroup C receptor-related protein 1 OS=Felis catus OX=9685 GN=FLVCR1 PE=1 SV=1)

HSP 1 Score: 38.5058 bits (88), Expect = 2.690e-6
Identity = 71/305 (23.28%), Postives = 128/305 (41.97%), Query Frame = 2 
Query: 1040 NTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKS-----SEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVG--NLCVFISSIIGGIL-GDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTM------LFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNL-GIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFM-----FFYKDERKRFNCDFGAPPNSCLEVNEDIEA---ERLCSDSSNEE 1885
            NT  N + +   +    +   S+A     L II F  KP+Y P ++     +    +   K     L +N    + F+L  IT G  +G    + +++  + +T  +    VS G   L + ++ ++G IL G    Y KI   +   T++ Y+L  L  M I    L + Y +++ +       F++  +  + FE   E+++P  E  ++ +L  A  + GI+  L+   +T     + P A G   L V  F+        K + +R N + G         N DI+A   E    DS  ++
Sbjct:  262 NTQNNTDLLACNISTMFYGTSSVATFLCFLTIIAFKEKPQYPPSQAQAALQNSPPAKYSYKKSIRNLFRN----VPFVLLLITYGIITGAFYSVSTLLNQMILTYYKGEE-VSAGKIGLTLVVAGMVGSILCGFWLDYTKIYKQT---TLIVYILSFL-GMVIFTFTLDLGYGIVVFVTGGVLGFFMTGYLP-LGFEFAVEITYPESEGTSSGLLNAAAQIFGILFTLAQGKLTTD---YSPKA-GNIFLCVWLFLGIILTALIKSDLRRHNINIGI-------ANGDIKAVPVEDTVEDSPTDK 545

HSP 2 Score: 35.4242 bits (80), Expect = 2.690e-6
Identity = 35/166 (21.08%), Postives = 70/166 (42.17%), Query Frame = 1 
Query:  460 RRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAI--IIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNND 951
            RRF +L  F +YS      W  +  +       Y  S+  ++ L+ +  +    LIFP   L +  G++      S +  LG  ++   C    Q +  +  +G  + +   +      + I+++WF   E S +  TA+  + LG+ +  ++   +  +  NN D
Sbjct:  106 RRFVVLLIFSLYSLVNAFQWIQYSVISNVFEGFYGVSSLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWVK---CASVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGAAIGFLLPPVLVPNTQNNTD 268
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. TrEMBL
Match: A0A210Q4Z9 (Disrupted in renal carcinoma protein 2-like OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT12618 PE=4 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 9.525e-28
Identity = 63/240 (26.25%), Postives = 110/240 (45.83%), Query Frame = 2 
Query: 1028 GNGTNTP-ENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIE----PLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSY-KKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISN------------ISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMI 1693
            GN ++ P E   K    +   ++  C  A+   LL+++YFP+KP  +P   S  + R++ K GC +L +N  FW+I      + G + G++   P ++E    P G+++ E   +     +C    S++     D FS  KK+++L +  T   + L+           + ++ + LL   FVS  I+             + FEM CE ++P  E +T  VL    NL  V  L++  I
Sbjct:  256 GNASSFPDETVLKKRNQIMNLLYIECGWAVAIFLLLLVYFPAKPT-IPPSISASTERLNFKQGCKKLLRNGVFWVI----ACSYGLSVGILGAWPGVLEMVLKPHGISENEAGLIGLYSVVCGIFLSLVAAKCSDVFSKSKKLILLGLYVTSGAFALW-----------MNLLLSRLLPDSFVSMHIATVVGGATLTATTPVYFEMACETTYPVAEGITNFVLALVNNLVSVAFLAIQTI 479

HSP 2 Score: 74.7146 bits (182), Expect = 9.525e-28
Identity = 44/172 (25.58%), Postives = 88/172 (51.16%), Query Frame = 1 
Query:  457 KRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHTF 972
            KRR+YILF +C+ + T  ++WN+W P+  S +E + W + +  LL +   I    ++F F  + ++ G+++A   ++ +++LG  +R    +     +   +G  ++  G  +S      +SA WFP  +R+ ST  A   +  G  ++ ++G  +  D  N+      +TF
Sbjct:   76 KRRWYILFVYCLLTLTQAMLWNTWGPIADSSHEAFGWDDGDTALLTDFGPIAFLLVVFLFSWIVDEKGLRWACVLTAFVMMLGAGLRCITDQPPYVKVTAGIGQFLNGIGTPVSMGVPPVLSAAWFPANQRTISTAIATVANLAGVGLSFVIGPFMVPDEKNSTGYTGHYTF 247
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. TrEMBL
Match: A7RLQ9 (Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g85723 PE=4 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 7.757e-27
Identity = 67/260 (25.77%), Postives = 115/260 (44.23%), Query Frame = 2 
Query: 1031 NGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCV-FISSIIGGILGDKFS--YKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            N T   + K++I     + M+    +     L ++IYFP KPK  P  ++    R+D   G   L + KQFW++  +  +++G   G  SVL   +   G+ Q +TA  +  G +    +S I   I  D F+   K I+I  +     + ++F L   KI+     V+Y   +   F  N    + FE+G E ++P  E +T+  L F+ N   V+     M+      WI +A   +    +P +  +K +  R   D
Sbjct:  182 NATTIQDYKDEI----MRLMYLEFGVTTFVFLCVLIYFPKKPKSPPSITAAIG-RLDFMVGAKALLRKKQFWLLVFIYGLSTGVYGGWCSVLDLNLSKFGIDQ-KTAGWLGFGAVVAGSLSGISLSIFADHFTRYMKTIIITLMMGATASLLIFTLVCAKILPKPAIVLYITSILGGFFVNGSIPLFFELGVESTYPIAEGITSGCLTFSNNFLQVIFYIFPMVPRFGTWWINWAALISCGTSIPLLVVWKAKYYRSAVD 435

HSP 2 Score: 73.559 bits (179), Expect = 7.757e-27
Identity = 44/171 (25.73%), Postives = 85/171 (49.71%), Query Frame = 1 
Query:  448 KPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKR 960
            K  KRR+YILF F I +    IIWNSW P+  +   ++ W +T + LL +   I     + P   L ++ G++ +   ++    +G  +R  P   S Q+++I +G  ++  G  ++   +  +SA WFP ++R+ +T  +      G+ ++ ++G  +  D    N  + 
Sbjct:    1 KVYKRRWYILFIFSIVATLNNIIWNSWGPIQGTSKVVFGWDDTIITLLADWGPISYVVAVVPMSWLMDEKGLRTSVVLAAFFEFIGSGLRCIPLDASSQSLLIHIGQFVTGLGGPVAMAAAPLVSAAWFPPSQRTTATAISSLACYSGTALSFVIGPLLVSDPSGANSTQN 171
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. TrEMBL
Match: A0A2T7PRP7 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_03071 PE=4 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 1.295e-26
Identity = 65/270 (24.07%), Postives = 124/270 (45.93%), Query Frame = 2 
Query: 1052 NKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSY--KKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFGAPPNSCLEVNEDIEAE 1855
            ++  +   +Q F   + + +    L+I+IYFP+KP   PC S+    R +   G   L + KQFW++  ++ +  G  +  ++V+   +   G+++ E   +     L   +  ++ G + D F+   K  V        V  +LFGL  M ++   + + YA ++    V N    + +E+ CE+++PTGE  T  VL   +++  ++ L V MI      W+ +      +  LP +   K+   R + D   P  S  ++N +I  E
Sbjct:  858 DRRPLLCSLQMFSTLNAAWSAALFLMILIYFPAKPPTPPCTSAGIQ-RENFLHGLKHLLRRKQFWLVAFISGVPIGALNCWLTVISVDLGARGISEKEAGWIGFYSILSAALLMLVIGRIADVFARAMKWFVFTLYLIGTVALLLFGLACMDVVTPSVALFYATVIISATVLNSTIPLIYELACELAYPTGEGTTNIVLTIVSSVSGLLFLFVGMIQSIGTLWMSWTLFGTCVCCLPLLMLLKERFGRRDVDEAYPNIS--DINTEITVE 1124

HSP 2 Score: 64.6994 bits (156), Expect = 1.295e-26
Identity = 42/160 (26.25%), Postives = 88/160 (55.00%), Query Frame = 1 
Query:  457 KRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXX--XXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKV 930
            +RR+Y+L  +C+++     +WN++ P+  S   ++ WSN +V LL N      ++  + F ++I  +  G++++  +S+ +V +G  +R    +      +I  G  ++  G  ++  G   +SA+WFPT ER+ +T     F+ LG  ++ ++G ++KV
Sbjct:  670 RRRWYVLAVYCLFALNQECVWNTFGPISHSSERVFGWSNGDVFLLTNWGPITYIISGVFFSWMI--DVKGLRWSSLSSAFLVTVGTALRCITMETPAATWLIHTGQLLNGLGGPVAMGGPPIVSAVWFPTEERATATAIGTTFNFLGFGLSFLLG-ELKV 826

HSP 3 Score: 60.4622 bits (145), Expect = 8.242e-12
Identity = 44/169 (26.04%), Postives = 90/169 (53.25%), Query Frame = 1 
Query:  421 ESEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXX-XXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDI 924
            ES     +YK   RR+YIL  F + +FT G +WN++ P+  +   ++ WSN ++ L+NN +        +F F  + +  G+++A  TS+ ++  G  +R F  +      ++ VG+ ++     ++      +SA+WFP  +R+ +T  + + + +G  MA ++G ++
Sbjct:  133 ESTQDAPVYK---RRWYILTVFSLIAFTQGCVWNAFGPISSTSQYVFKWSNGDIALINNWVFISYFLGGVF-FSWMLDVKGLRWACVTSAFLMAGGSTLRCFSMEAPAITWLVNVGHLLNGLAGPVAMGAPPFLSAVWFPLHQRATATAVSTSSNFVGVAMAFVLGPNL 297

HSP 4 Score: 40.817 bits (94), Expect = 8.242e-12
Identity = 48/198 (24.24%), Postives = 89/198 (44.95%), Query Frame = 2 
Query: 1016 PTFSGNGTNTPENK-EKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWII-FLLNFITSGFN-SGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSY--KKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMG 1594
            P  S N T + E++  +    +Q +M          +L ++IYFP+KP   PC S+    R     G   L + K F ++ +L+  +   F+ SG++ +  S+     + + E   +   G +   I+S+I     DKF+   K  V++      + +++F L S  +I   +G+ Y   +  L   N    + FE+G
Sbjct:  337 PQMSVNPTESEESRIVQTKENIQIYMIIEAVWCGVLLLTVLIYFPAKPPTPPCASAGVQ-RESFLQGLKSLLRKKMFVMVTYLVLAVGVVFSWSGMIYISLSVHN---IEEKEAGWIGFYGIIASAIASLIIARFADKFARIMKWCVLVQFAVGSLQFLIFALASSNVITPSVGLFYTTTILALLALNSSLPLLFEIG 530
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. TrEMBL
Match: A0A0L8IAN6 (MFS domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22024475mg PE=4 SV=1)

HSP 1 Score: 85.8853 bits (211), Expect = 5.455e-26
Identity = 70/266 (26.32%), Postives = 131/266 (49.25%), Query Frame = 2 
Query: 1031 NGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFIS------SIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSM-KIIRH--ELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            N +   ++ EK  + ++  +F    ++     L++IYFP+KP   P  S+    R++   G   L KN +FW++  +  + SG  S  ++V+   ++P  ++Q       SVG   ++I       S++   L D F     + LS   TI   +L   Q M + + H  ++ +  ++ L+M+F+++I   I +EM  E +FP  E V   VL   +N   +V L + MI +  V+W+ +    AV+ VLP +  ++++ +R   D
Sbjct:  257 NSSVYEDHLEKERIELRTLLFSEFGMSAVIFFLVVIYFPNKPPSPPTMSARME-RLNFTEGITNLMKNYRFWMLAAIYTLCSGVISSWLAVIYINLKPHNISQ------KSVGIFSIYIGIGSCLGSLVLAKLSDMFVNYTRIFLSALITISIGLLTWFQLMYENVLHITDVQLTLSITLSMIFLTSIYP-ILYEMSSEAAFPIAEGVANGVLNLLSNAVSLVFLFILMIPNIGVSWMNWTLLTAVICVLPVICAFRNKFRRIEID 514

HSP 2 Score: 63.1586 bits (152), Expect = 5.455e-26
Identity = 51/183 (27.87%), Postives = 89/183 (48.63%), Query Frame = 1 
Query:  427 EDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLW--SNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHT 969
            ++ +  +K  KRR+YILF F  ++FT  + WN+W P+ ++ NEL+ W  SN  +          +C+L   ++I     G++     +S  + LG  IR    K      +  VG  I  +    +   STA+S+ WFP  +R  +T  A  F TLG+  +  VG  +     + +++  +H+
Sbjct:   71 DENQQSFKVYKRRWYILFLFAFFAFTQSLHWNTWPPIAQTTNELFGWTVSNVALLTNWGPITYTLCALPISWVI--ETKGLRTTCLITSLSLFLGSGIRSITLKTPYIYWLSNVGQIIIGFAAPFTISASTALSSAWFPMHQRFTATAIANVFLTLGASASLFVGPLVVSTNASISNSTSNHS 251
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. TrEMBL
Match: A0A0L8IAU0 (MFS domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22024475mg PE=4 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 6.337e-26
Identity = 70/266 (26.32%), Postives = 131/266 (49.25%), Query Frame = 2 
Query: 1031 NGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFIS------SIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSM-KIIRH--ELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            N +   ++ EK  + ++  +F    ++     L++IYFP+KP   P  S+    R++   G   L KN +FW++  +  + SG  S  ++V+   ++P  ++Q       SVG   ++I       S++   L D F     + LS   TI   +L   Q M + + H  ++ +  ++ L+M+F+++I   I +EM  E +FP  E V   VL   +N   +V L + MI +  V+W+ +    AV+ VLP +  ++++ +R   D
Sbjct:  218 NSSVYEDHLEKERIELRTLLFSEFGMSAVIFFLVVIYFPNKPPSPPTMSARME-RLNFTEGITNLMKNYRFWMLAAIYTLCSGVISSWLAVIYINLKPHNISQ------KSVGIFSIYIGIGSCLGSLVLAKLSDMFVNYTRIFLSALITISIGLLTWFQLMYENVLHITDVQLTLSITLSMIFLTSIYP-ILYEMSSEAAFPIAEGVANGVLNLLSNAVSLVFLFILMIPNIGVSWMNWTLLTAVICVLPVICAFRNKFRRIEID 475

HSP 2 Score: 63.1586 bits (152), Expect = 6.337e-26
Identity = 51/183 (27.87%), Postives = 89/183 (48.63%), Query Frame = 1 
Query:  427 EDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLW--SNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHT 969
            ++ +  +K  KRR+YILF F  ++FT  + WN+W P+ ++ NEL+ W  SN  +          +C+L   ++I     G++     +S  + LG  IR    K      +  VG  I  +    +   STA+S+ WFP  +R  +T  A  F TLG+  +  VG  +     + +++  +H+
Sbjct:   32 DENQQSFKVYKRRWYILFLFAFFAFTQSLHWNTWPPIAQTTNELFGWTVSNVALLTNWGPITYTLCALPISWVI--ETKGLRTTCLITSLSLFLGSGIRSITLKTPYIYWLSNVGQIIIGFAAPFTISASTALSSAWFPMHQRFTATAIANVFLTLGASASLFVGPLVVSTNASISNSTSNHS 212
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Cavefish
Match: slc49a4 (solute carrier family 49 member 4 [Source:NCBI gene;Acc:103033823])

HSP 1 Score: 50.8322 bits (120), Expect = 2.108e-12
Identity = 39/174 (22.41%), Postives = 78/174 (44.83%), Query Frame = 1 
Query:  460 RRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFP---FIILWNKCGIKFAYTTSSCIVLLGCLIRVFP-CKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHT 969
            RR+ +L  F    F  G++WN+W P+  S    Y +S+T++ +L     +      FP   F+ L +K G++ +   ++ +++LG  +R+ P     ++  +I  G  ++             +S  WF   +R+ +T  A     LG+  + + G  + V   N+     + T
Sbjct:   39 RRWVVLALFSALGFLQGLVWNTWGPIQNSAKHAYGFSSTDIAVLVIWGPVG----FFPWLLFVWLMDKKGLRASLLLAAFLMVLGAALRIIPLTDLQLRRWLIHGGQLLNGLAGPTLMSAGPLLSTTWFAPDQRATATAVASLVGYLGAACSFLAG-PLAVPAPNDTQTVSTTT 207

HSP 2 Score: 41.5874 bits (96), Expect = 2.108e-12
Identity = 26/105 (24.76%), Postives = 49/105 (46.67%), Query Frame = 2 
Query: 1037 TNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETA 1351
            T T  + E I   ++  ++      +     +++YFPS+P  +P   +  S R+  +S    L  N +F +I L   + +G  +G   VL  I+ P  V+Q++  
Sbjct:  205 TTTHWDPEHIRHRIEIVLYAELGAIVLLFAAVLLYFPSRPP-IPPSVAAASQRLSYRSSICRLMSNMRFLMIALAYSVPTGVVAGWSGVLDMILTPAKVSQVDAG 308
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Cavefish
Match: slc49a4 (solute carrier family 49 member 4 [Source:NCBI gene;Acc:103033823])

HSP 1 Score: 50.447 bits (119), Expect = 2.596e-8
Identity = 39/174 (22.41%), Postives = 78/174 (44.83%), Query Frame = 1 
Query:  460 RRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFP---FIILWNKCGIKFAYTTSSCIVLLGCLIRVFP-CKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHT 969
            RR+ +L  F    F  G++WN+W P+  S    Y +S+T++ +L     +      FP   F+ L +K G++ +   ++ +++LG  +R+ P     ++  +I  G  ++             +S  WF   +R+ +T  A     LG+  + + G  + V   N+     + T
Sbjct:   39 RRWVVLALFSALGFLQGLVWNTWGPIQNSAKHAYGFSSTDIAVLVIWGPVG----FFPWLLFVWLMDKKGLRASLLLAAFLMVLGAALRIIPLTDLQLRRWLIHGGQLLNGLAGPTLMSAGPLLSTTWFAPDQRATATAVASLVGYLGAACSFLAG-PLAVPAPNDTQTVSTTT 207

HSP 2 Score: 27.7202 bits (60), Expect = 2.596e-8
Identity = 20/82 (24.39%), Postives = 36/82 (43.90%), Query Frame = 2 
Query: 1037 TNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIEL--AKNKQFWIIFLLNFITS 1276
            T T  + E I   ++  ++      +     +++YFPS+P  +P   +  S R+  +S    L  A      II + N I+S
Sbjct:  205 TTTHWDPEHIRHRIEIVLYAELGAIVLLFAAVLLYFPSRPP-IPPSVAAASQRLSYRSSICRLMSAYRTTVLIILIFNHISS 285
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Sea Lamprey
Match: slc49a4 (solute carrier family 49 member 4 [Source:ZFIN;Acc:ZDB-GENE-040912-167])

HSP 1 Score: 72.4034 bits (176), Expect = 1.011e-13
Identity = 47/159 (29.56%), Postives = 83/159 (52.20%), Query Frame = 1 
Query:  457 KRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXX--XXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYS-IQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDI 924
            +RR+ +L +FC  SF  G +WN+W P+ +S   ++ W   +V LL        ++C L    ++L +K G++ +   +S +V+LGC +RV P   S  +  +IQVG  ++      +      +SA WFP  +R+ +T  A     LG+  A ++G  +
Sbjct:   40 RRRWAVLAAFCCLSFLQGQVWNTWGPVAESARLVFGWGPGDVALLVVWGPVGFILCPL---SVLLLDKRGLRSSLLATSLVVVLGCSLRVIPTADSATRKWLIQVGQLLNGIAGTTTMAAPPYLSAAWFPAKQRTTATAIASLIGYLGAASAFLLGPAV 195

HSP 2 Score: 65.0846 bits (157), Expect = 2.118e-11
Identity = 55/228 (24.12%), Postives = 108/228 (47.37%), Query Frame = 2 
Query: 1145 PSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFS------YKKIVILSIPPTIVTYVLFGLQS---MKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            P+ P   P  S+  + R+  ++   +LA++++FW+I L   + SG   G   VL  I+ P GV+Q +      VG  C  + SI G I+   F+       K ++++      +  V F L S   +  +  + G +YA  L +   +N    + FE+  E ++P  E +T  ++ F +NL   ++L+  M+  ++V W+ +    + +L +  +  Y++   R   +
Sbjct:  238 PALPPRPPSLSAAAT-RLPYRAALRKLARSRRFWLIALAYGVASGVVGGWSGVLDVILSPNGVSQAKAGW---VGFSCTTVGSIAGIIISRWFADYFAGQLKAMLMVIYTAATLAAVWFTLMSYGNIPFLPFDTGSLYACTLLLGVTTNSSIPLFFELFVETTYPVPEGITCGIVTFLSNLFAGLLLAFLMVYPEDVLWLNWVLVFSCVLTVFLVLLYREGYNRLKLE 461
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Nematostella
Match: EDO47735 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLQ9])

HSP 1 Score: 78.1814 bits (191), Expect = 1.604e-30
Identity = 67/260 (25.77%), Postives = 115/260 (44.23%), Query Frame = 2 
Query: 1031 NGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCV-FISSIIGGILGDKFS--YKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            N T   + K++I     + M+    +     L ++IYFP KPK  P  ++    R+D   G   L + KQFW++  +  +++G   G  SVL   +   G+ Q +TA  +  G +    +S I   I  D F+   K I+I  +     + ++F L   KI+     V+Y   +   F  N    + FE+G E ++P  E +T+  L F+ N   V+     M+      WI +A   +    +P +  +K +  R   D
Sbjct:  182 NATTIQDYKDEI----MRLMYLEFGVTTFVFLCVLIYFPKKPKSPPSITAAIG-RLDFMVGAKALLRKKQFWLLVFIYGLSTGVYGGWCSVLDLNLSKFGIDQ-KTAGWLGFGAVVAGSLSGISLSIFADHFTRYMKTIIITLMMGATASLLIFTLVCAKILPKPAIVLYITSILGGFFVNGSIPLFFELGVESTYPIAEGITSGCLTFSNNFLQVIFYIFPMVPRFGTWWINWAALISCGTSIPLLVVWKAKYYRSAVD 435

HSP 2 Score: 73.559 bits (179), Expect = 1.604e-30
Identity = 44/171 (25.73%), Postives = 85/171 (49.71%), Query Frame = 1 
Query:  448 KPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKR 960
            K  KRR+YILF F I +    IIWNSW P+  +   ++ W +T + LL +   I     + P   L ++ G++ +   ++    +G  +R  P   S Q+++I +G  ++  G  ++   +  +SA WFP ++R+ +T  +      G+ ++ ++G  +  D    N  + 
Sbjct:    1 KVYKRRWYILFIFSIVATLNNIIWNSWGPIQGTSKVVFGWDDTIITLLADWGPISYVVAVVPMSWLMDEKGLRTSVVLAAFFEFIGSGLRCIPLDASSQSLLIHIGQFVTGLGGPVAMAAAPLVSAAWFPPSQRTTATAISSLACYSGTALSFVIGPLLVSDPSGANSTQN 171
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Nematostella
Match: EDO47645 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLQ7])

HSP 1 Score: 63.5438 bits (153), Expect = 7.104e-17
Identity = 48/179 (26.82%), Postives = 86/179 (48.04%), Query Frame = 1 
Query:  418 MESED---KRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCK-YSIQAIIIQVGN-AISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGS----VMAPIVGNDIK 927
            +E ED    +   K   +R+Y+L  F + + T  ++WN+W P+ ++   ++ W+ T V ++  + A      + P     +  G++ A  TS  + L+G ++ + P   Y  +  +I  G   I+    ++  VG   +SA WFP  ER  +T  A   S LGS    VM P +  D++
Sbjct:   25 LEDEDSIPNKPEIKTYPQRWYMLIVFTLLNATTNLLWNTWPPIQETCQLVFGWTKTNVLIIGALQAGGSILSVIPSSWFIDTKGLRVAVVTSLSVQLVGVVLEILPVHPYWARTTLITFGEFLIAIAAPVVQNVGVLVLSASWFPPEERMTATAFATLVSYLGSASSYVMGPYMVPDVE 203

HSP 2 Score: 41.9726 bits (97), Expect = 7.104e-17
Identity = 54/267 (20.22%), Postives = 103/267 (38.58%), Query Frame = 2 
Query: 1040 NTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGV-----IYAVLLTMLFVSNIISNISF--------EMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
             +P   + +   + +++   C +      L+ IYFP +    P   S    R+D   G   L  NK F ++  +  I++G N G  SV   I   +G++Q     L   GN        I   +   FS+    I          +L GL  M +    +       ++ +  T+ +VS I + + +        EM  E ++P  E +T+ VL  +     +      M    +  W+ +   ++  + +P +  +K +  R + D
Sbjct:  224 TSPAQLKLMESKINEYILVECVLTGVLFFLVWIYFP-EKPPTPPSISSSKPRLDFIPGAKTLMTNKHFLLLLAIFSISNGVNWGWSSVQDLIFSHVGISQKAAGWLGFFGN--------IASTIAIAFSWYADRI----KRFTKRILMGLFVMTVCCQTVLTLACEQVFPLTTTIFYVSGISAMVFYCGTVPLVMEMAAECTYPVAEGITSGVLILSVYTFNLFFFIGFMFPQASPLWMNWLLVSSSAICIPLIACFKGKYNRLDVD 477
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Nematostella
Match: EDO40262 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7M7])

HSP 1 Score: 73.559 bits (179), Expect = 7.589e-14
Identity = 59/229 (25.76%), Postives = 102/229 (44.54%), Query Frame = 2 
Query: 1124 LLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFS--YKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIY-AVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            L ++IYFP KP  +P   S +  R D  +G   + KN  FW + L+  IT+G  SG  + L   +E   V+Q     L     L    + +I     D F    K I+++    +   ++ F L  ++ I ++   +Y + ++   FVS  I  + +E+  E ++P  E VT  +L    N   V  L +  I      W+ +    A    +P M  ++++ +R N D
Sbjct:  199 LAVVIYFPDKPP-LPPSHSARIQREDFFAGTKRIVKNSSFWTLALVYGITTGVYSGWGASLAVNLETFNVSQSAAGWLGFYATLAGIGAGLILARCADLFGGRMKAILVVLFFGSSGCFLWFALLCLRKIPYDSNSLYKSSIMGGFFVSGTIP-LFYELTVESTYPVAEGVTCGLLTLVNNFFTVAFLVILTIPGVGTVWMNWCMFGACAAGIPIMLSFREKYRRLNID 425

HSP 2 Score: 62.3882 bits (150), Expect = 2.614e-10
Identity = 40/167 (23.95%), Postives = 80/167 (47.90%), Query Frame = 1 
Query:  448 KPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNN 948
            +  +RRFYILF F I SF     WN++ P+  +   ++ WSNTE+ +L +++ I     +  F  + +  G++ +   S+  + +G  +R      +     +  G  ++     ++      +SA WFP+ +R+ +T  A    +LG  M+ ++G     D  + +
Sbjct:    1 RVFRRRFYILFLFSIISFAQYCAWNTYGPIATTAKTVFDWSNTEIAVLASMDPITYLVTMLFFSWMMDVKGLRKSMLVSTAFMFVGTGLRCVTPDSTYAIWTMGGGQLLNGLAGPVTQAAPPLLSAAWFPSHQRTTATAVAALCGSLGVAMSFVIGPAFVTDLSHTS 167
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Nematostella
Match: EDO48894 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHQ4])

HSP 1 Score: 53.1434 bits (126), Expect = 1.374e-12
Identity = 44/169 (26.04%), Postives = 79/169 (46.75%), Query Frame = 1 
Query:  460 RRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLG----SVMAPIV--GNDIKVDRCNNN 948
            RR+YIL  F + +   G +WN+W P+  S   +Y WS+  + LL N   I        F  L +  G++ +   +  ++ LG  IR    K +    +I +G  ++  G  ++      +S+ WFP  +R+ +T  +   S +G     ++AP +   ND   +  +NN
Sbjct:    5 RRWYILVVFSLIAGLQGCVWNTWGPITGSAGAVYGWSDGTIALLENWGPITYILSFILFSWLLDVKGLRVSVLVTILLMTLGIGIRCITTKPAPATWLIHIGQFLNDLGAPVAMGAPPLLSSTWFPPNQRATATAISTLTSYVGISASFLVAPFIVNPNDFTNNTFHNN 173

HSP 2 Score: 38.1206 bits (87), Expect = 1.374e-12
Identity = 55/263 (20.91%), Postives = 113/263 (42.97%), Query Frame = 2 
Query: 1022 FSGNGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFS--YKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIY-AVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            F+ N  +      K   G+Q +++    +A   ++L+++YFP+KP + P  S+ +  + D   G  +L    ++        +  G  SG   VL   +    V Q+++  +    N+   +  +I     D F+   K  +I     +  +++ F L     I      +Y + +L   F++  I  + +E+  E ++P  E V  AV+  + +L  ++ L+   I      W+ +   A     +P +FF+K++  R   D
Sbjct:  165 FTNNTFHNNMTVGKARDGIQIYLYAELGLAGLLLVLVLLYFPAKPPHPPSFSAARE-KADYLQGAKQLLNMPKY-CYHHEYLLYVGVFSGWGGVLAVNLLAFNVKQVQSGWIGFYSNMAGCVLGMIMARSADFFAGRMKCFLIFLFIGSTGSFLWFSLLCQDAIPFSKVWLYVSAILGGCFINGSIP-LFYELTVETTYPIAEGVPMAVVTTSNHLACLLFLAALNIPGIGTVWMNWCMVAICAGCIPMLFFFKEKYSRLELD 424
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Nematostella
Match: EDO48766 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI77])

HSP 1 Score: 64.3142 bits (155), Expect = 7.552e-11
Identity = 63/281 (22.42%), Postives = 130/281 (46.26%), Query Frame = 2 
Query: 1001 GTRIVP---TFSGNGTN-------TPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGD--KFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFG 1807
            G +IVP   +F+ N TN       T  +K+ +   + ++M+    + +     +I+YFPSKP   P  S+    +  LKS   E++++  FW++  +  ++ G   G +SVL   + P  +++     L  +G+L   +S+I+     D  +   K I+I+    + +  + F +   + I +   ++Y  ++         + + FE+  E  +P  + + T  L   +++  VV   V M    +VTW+ +   A   + +P +  +K++  R + D G
Sbjct:  197 GPQIVPDPESFATNFTNHISAINVTDADKQLMATRIAKYMYGELGLLIFVTFCLILYFPSKPPLPPSLSTRSRKKTGLKSELSEISRDVWFWLLTFVFSVSYGSYYGWISVLDVAVAPFEISEDTAGWLGCLGSLAGVLSAILAARCADLTRRYTKLILIILFTGSTLCLLFFTITCERYIPYSEPLLYVYIIGSGLFFTGTTPLFFELIIEYVYPVSDSLATGNLLLWSSVLGVVFCVVFMFPSVDVTWMNWVNMAGCSVCVPVLILFKEKYTRLDLDLG 477

HSP 2 Score: 62.3882 bits (150), Expect = 2.653e-10
Identity = 49/189 (25.93%), Postives = 90/189 (47.62%), Query Frame = 1 
Query:  424 SEDKRIIYKPLKRRFYILFSFCIYSFTGGI---IWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFP-CKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHTFAL 978
            S DK ++ K  KRR+YILF   IYSF   +   +WN W P+ +S   ++ W   +V L++          + P   +  + G++     +S  + +G  +++ P     ++  ++ +G  I+   + M+      +SA+WFP  ER+ +T  A+    +GS  +  VG  I  D  +   N  +H  A+
Sbjct:   34 SADK-LLCKVYKRRWYILF---IYSFQVTLQNAVWNFWGPIQESCKIVFGWEKFDVLLISVWGPASAVIALVPGTWVLARKGLRPTILLTSFFICIGKALQIVPFTDQDVRTAVVNIGQMIAMTSSFMTVCVPAVLSAVWFPPHERATATTLAMVAGYIGSAASFAVGPQIVPDPESFATNFTNHISAI 218
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Medaka
Match: slc49a4 (solute carrier family 49 member 4 [Source:NCBI gene;Acc:101159954])

HSP 1 Score: 56.225 bits (134), Expect = 2.152e-15
Identity = 61/270 (22.59%), Postives = 113/270 (41.85%), Query Frame = 2 
Query: 1031 NGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATL---VSVGNLCVFISSIIGGILGDKFS------YKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNIS----FEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            NG     +   I   +Q  ++   +        I  +FPS P  +P   +  S R+  +S    L  N +F ++ L   + +G  +G   VL  ++ P  V+Q++   +    ++G  CVF      G+   +F+       K I++L +    ++   F L  +  + H L    A+L T   ++ I  N S    FE+  E  +P  E +T  V+ F  NL   ++L        +VTW+ +    + +  L  + F+++   R   D
Sbjct:  198 NGVAAAVSDNSIQDRIQLILYAELAAVGVLFTAIFFFFPSWPP-IPPSVAAASQRLSYRSSICRLLSNLRFLMVALAYAVPTGVIAGWTGVLDMVLTPAKVSQVDAGWIGFWSTIGG-CVF------GVAMARFADSIRGMLKLILVLMLAGASLSSTWFTLTCLSSVTH-LPSTSAILYTSCILTGIFINSSVPIFFELLIETVYPVPEGITCGVVTFLGNLFTGLLLFFLTFYCTDVTWLNWCLTGSCIFSLTLILFFRESYDRLYLD 458

HSP 2 Score: 46.2098 bits (108), Expect = 2.152e-15
Identity = 39/154 (25.32%), Postives = 72/154 (46.75%), Query Frame = 1 
Query:  457 KRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPC-KYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVG 915
            +RR+ +L  F +     G+IWN W P+  S    Y +SN+E+ +L     +     +  F+ L +K G++ +   S+ ++LLG  +R  P     ++  +I  G  ++      +      +S  WF   +R+ +T  A  F  LG   + +VG
Sbjct:   32 RRRWLVLTLFSLLGLMQGMIWNFWGPIQNSAVLAYGFSNSEIAVLVLWGPVGFVPWLL-FMWLMDKKGLRVSLLLSAFLMLLGAGLRSVPLPDLHLRRWLIHGGQLLNGLAGPTTMSAGPYLSTTWFAPDQRATATAVASLFCYLGGAASFLVG 184
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Medaka
Match: slc49a4 (solute carrier family 49 member 4 [Source:NCBI gene;Acc:101159954])

HSP 1 Score: 46.2098 bits (108), Expect = 2.513e-12
Identity = 39/154 (25.32%), Postives = 72/154 (46.75%), Query Frame = 1 
Query:  457 KRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPC-KYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVG 915
            +RR+ +L  F +     G+IWN W P+  S    Y +SN+E+ +L     +     +  F+ L +K G++ +   S+ ++LLG  +R  P     ++  +I  G  ++      +      +S  WF   +R+ +T  A  F  LG   + +VG
Sbjct:   32 RRRWLVLTLFSLLGLMQGMIWNFWGPIQNSAVLAYGFSNSEIAVLVLWGPVGFVPWLL-FMWLMDKKGLRVSLLLSAFLMLLGAGLRSVPLPDLHLRRWLIHGGQLLNGLAGPTTMSAGPYLSTTWFAPDQRATATAVASLFCYLGGAASFLVG 184

HSP 2 Score: 45.4394 bits (106), Expect = 2.513e-12
Identity = 52/222 (23.42%), Postives = 93/222 (41.89%), Query Frame = 2 
Query: 1031 NGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATL---VSVGNLCVFISSIIGGILGDKFS------YKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNIS----FEMGCEVSFPTGEEVTTAVLGFATN 1657
            NG     +   I   +Q  ++   +        I  +FPS P  +P   +  S R+  +S    L  N +F ++ L   + +G  +G   VL  ++ P  V+Q++   +    ++G  CVF      G+   +F+       K I++L +    ++   F L  +  + H L    A+L T   ++ I  N S    FE+  E  +P  E +T  V+ F  N
Sbjct:  198 NGVAAAVSDNSIQDRIQLILYAELAAVGVLFTAIFFFFPSWPP-IPPSVAAASQRLSYRSSICRLLSNLRFLMVALAYAVPTGVIAGWTGVLDMVLTPAKVSQVDAGWIGFWSTIGG-CVF------GVAMARFADSIRGMLKLILVLMLAGASLSSTWFTLTCLSSVTH-LPSTSAILYTSCILTGIFINSSVPIFFELLIETVYPVPEGITCGVVTFLGN 410
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Planmine SMEST
Match: SMESG000017031.1 (SMESG000017031.1)

HSP 1 Score: 636.336 bits (1640), Expect = 0.000e+0
Identity = 314/316 (99.37%), Postives = 315/316 (99.68%), Query Frame = 2 
Query: 1001 GTRIVPTFSGNGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFGAPPNSCLEVNEDIEAERLCSDSSNEEIGNESEDEYKNVDYSSLRFLS 1948
            GTRIVPTFSGNGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFGA PNSCLEVNED+EAERLCSDSSNEEIGNESEDEYKNVDYSSLRFLS
Sbjct:  166 GTRIVPTFSGNGTNTPENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFGASPNSCLEVNEDVEAERLCSDSSNEEIGNESEDEYKNVDYSSLRFLS 481

HSP 2 Score: 314.309 bits (804), Expect = 9.116e-100
Identity = 169/179 (94.41%), Postives = 169/179 (94.41%), Query Frame = 1 
Query:  418 MESEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDN 954
            MESEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEVNLLNNINAIVVCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVG  I      N  N
Sbjct:    1 MESEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEVNLLNNINAIVVCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGTRIVPTFSGNGTN 179
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Planmine SMEST
Match: SMESG000017042.1 (SMESG000017042.1)

HSP 1 Score: 258.455 bits (659), Expect = 1.999e-111
Identity = 136/290 (46.90%), Postives = 185/290 (63.79%), Query Frame = 2 
Query:  995 FSGTRIVPTFSGNGTNTPE--NKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFGAP-PNSCLEVNEDIEAE 1855
            F G+ IVP    N ++T    +  +I  GM QF++   ++A+  V LI IYFP+KP   PC+SSE SLRID  SG   L++NKQFWI+F++NFIT G NSGV +V  S I PLG+ Q     L  V     F++ I+GG LG+ F  K IV+ SI PTI+ Y+L G Q++K+I + +  IY + +T+ F+SNI+  ISFEMGCE +FPT EEV T  LGFATNLGI + ++VTMI +    WIPF+Y    + +LP MFFY+++ KR  CD  +  PNS   +  D   E
Sbjct:  166 FIGSLIVPDIKFNISDTSNIISTVEIEKGMVQFLYLQAALAVICVTLIAIYFPAKPPIPPCRSSESSLRIDYWSGMKSLSRNKQFWIVFVVNFITFGVNSGVGAVFTSYILPLGMNQKSIGILNMVTTFVTFLAGIVGGWLGEYFKSKTIVLCSIFPTILMYLLCGFQTLKMINYSIISIYLLNVTLSFISNIVCPISFEMGCEAAFPTSEEVATGALGFATNLGISIFIAVTMIPNIGTFWIPFSYAGLTIFLLPLMFFYRNDAKRKECDINSENPNSFESIQNDYSVE 455

HSP 2 Score: 164.851 bits (416), Expect = 1.999e-111
Identity = 82/170 (48.24%), Postives = 119/170 (70.00%), Query Frame = 1 
Query:  424 SEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVD 933
             ED +++YKP+K RFYIL SF  Y+F  G  WN+WQP+++SI+ LY W  +++N+LN I +I+ C  I PFI LWNK GI   Y TS+ + L+G  I +FPC   IQ+I++Q+G+ I ++G LMS  G+  ISAIWFP+ ERSR+T T ++ ++LGS  +P +G+ I  D
Sbjct:    5 DEDPKVLYKPVKSRFYILLSFSFYTFMCGFQWNAWQPIMRSIHILYKWDISQINILNFIPSIIYCLCIIPFIHLWNKFGIASVYRTSASLFLIGAFIPLFPCSLDIQSILLQIGSVIKSFGALMSITGAPVISAIWFPSRERSRATATLISLNSLGSAFSPFIGSLIVPD 174
[Close]
BLAST of Disrupted in renal carcinoma protein 2-like vs. Planmine SMEST
Match: SMESG000017053.1 (SMESG000017053.1)

HSP 1 Score: 226.098 bits (575), Expect = 1.632e-66
Identity = 118/269 (43.87%), Postives = 169/269 (62.83%), Query Frame = 2 
Query: 1001 GTRIVPTFSGNGTNTP--ENKEKIHLGMQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIELAKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNLCVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGVIYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVILSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCD 1801
            GT +VP    N +N         I  G+ +F++   ++A+  + LI++YFP+KP   PC+SSEK LRID  +G   L KNK+FWI+F+L FIT G +SGV SV  S I PLG+TQ +   L  V  +  F+  + GG +G     K +V+ +I PTI+ YVL G Q++K+I +    IY + + + F+ +II  I+FEMGCE +FP  EEV T VLGFATNLGI + ++VTMI +    WIPF+Y    + ++P M+FYK++ KR  CD
Sbjct:  167 GTFMVPDVVFNKSNNKIITKVSDIEKGVSKFLYLQAALAVICLTLILVYFPAKPDIPPCRSSEKFLRIDYLAGIKSLKKNKEFWIVFILVFITYGVSSGVGSVFTSYILPLGMTQKDVGILNMVTTIVTFLGGMFGGWVGVYVKSKTLVVWTIFPTILLYVLSGFQTIKMIDYSTPSIYVLNIFLSFIPSIICPITFEMGCEAAFPASEEVATGVLGFATNLGISIFIAVTMIPNIGTFWIPFSYAGITVFLIPLMYFYKNDVKRKECD 435

HSP 2 Score: 150.214 bits (378), Expect = 6.729e-39
Identity = 72/172 (41.86%), Postives = 117/172 (68.02%), Query Frame = 1 
Query:  445 YKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLWSNTEXXXXXXXXXXXXCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIRVFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCTALAFSTLGSVMAPIVGNDIKVDRCNNNDNKR 960
            YKP+K RFY++F    Y+F  G +W++WQP+++SI+ LY W  T++N+L+ I++I+ C  I PFI LWNK GI   Y  S C++++G  + +FP   ++Q+I++Q+G+ I+++G L+S  G   ISA+WFPT ER+ +T T ++ +TLGS  +PI+G  +  D   N  N +
Sbjct:   11 YKPVKSRFYMMFVLSFYTFFCGFLWSAWQPIMRSIHVLYNWDLTQINVLSFISSIIYCIFIIPFIHLWNKFGIVCVYQFSVCLLVIGTFVPLFPSSLTVQSILLQIGSMITSFGALVSITGCPVISAVWFPTKERTIATATLISVNTLGSAFSPIIGTFMVPDVVFNKSNNK 182
The following BLAST results are available for this feature:
BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
slc49a42.434e-1622.65solute carrier family 49 member 4 [Source:ZFIN;Acc... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
kif13b3.859e-624.89kinesin family member 13B [Source:Xenbase;Acc:XB-G... [more]
kif13b4.641e-626.18kinesin family member 13B [Source:Xenbase;Acc:XB-G... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Disrupted in renal carcinoma protein 2-like vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|Q6GNV7|DIRC2_XENLA7.676e-726.80Solute carrier family 49 member 4 homolog OS=Xenop... [more]
sp|Q9N1F2|FLVC1_FELCA2.690e-623.28Feline leukemia virus subgroup C receptor-related ... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A210Q4Z99.525e-2826.25Disrupted in renal carcinoma protein 2-like OS=Miz... [more]
A7RLQ97.757e-2725.77Predicted protein (Fragment) OS=Nematostella vecte... [more]
A0A2T7PRP71.295e-2624.07Uncharacterized protein OS=Pomacea canaliculata OX... [more]
A0A0L8IAN65.455e-2626.32MFS domain-containing protein OS=Octopus bimaculoi... [more]
A0A0L8IAU06.337e-2626.32MFS domain-containing protein OS=Octopus bimaculoi... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
slc49a42.108e-1222.41solute carrier family 49 member 4 [Source:NCBI gen... [more]
slc49a42.596e-822.41solute carrier family 49 member 4 [Source:NCBI gen... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
slc49a41.011e-1329.56solute carrier family 49 member 4 [Source:ZFIN;Acc... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO477351.604e-3025.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476457.104e-1726.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO402627.589e-1425.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO488941.374e-1226.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO487667.552e-1122.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
slc49a42.152e-1522.59solute carrier family 49 member 4 [Source:NCBI gen... [more]
slc49a42.513e-1225.32solute carrier family 49 member 4 [Source:NCBI gen... [more]
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BLAST of Disrupted in renal carcinoma protein 2-like vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000017031.19.116e-10099.37SMESG000017031.1[more]
SMESG000017042.11.999e-11146.90SMESG000017042.1[more]
SMESG000017053.11.632e-6643.87SMESG000017053.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034544 ID=SMED30034544|Name=Disrupted in renal carcinoma protein 2-like|organism=Schmidtea mediterranea sexual|type=transcript|length=1985bp
GTGCGTAATATAATCTAAATATTAAAAAAATGTACATCATTTTTTATAAA
TTTATATTACAATATTTAAATAAATCATCGACATTGAAAGTGATAACAAA
CTGATTGATAATATACCAACTAAAAGCGTAGACTGAAAACAATATCTAAC
ATATTGCCAACCAATCGAGGAGATTGGTCCAGTTTTTAATATCAATTACT
TAATGAATTTTGTTTAAGTTGAATATGAAATATGAAATTACCTTTTATGT
TGCAATATCTAGAGAAACTTCAAAAGCAAGAATGAATATTATGTTCCTAG
ACACAGAAGCCTGGTAAGACTTCATAGGAATGATAAGTTATGTCGTCTTT
ACGAAAATATTTTAAATCTTAAATTATATTTTAATGTTTTAAATATTTTT
ATTATTTTTTTTAAACAATGGAATCCGAAGATAAACGAATTATATACAAA
CCTTTAAAAAGGCGATTTTATATTTTATTTTCATTTTGTATATATTCATT
TACTGGTGGCATTATTTGGAATTCGTGGCAGCCATTGATCAAGTCGATAA
ATGAATTGTATTTGTGGTCTAATACGGAAGTGAATCTTTTGAATAATATA
AATGCCATAGTTGTTTGTTCTCTTATTTTTCCTTTTATTATTTTGTGGAA
CAAATGTGGAATAAAATTTGCATACACAACAAGCAGTTGTATAGTTTTAT
TAGGATGTTTAATTAGAGTTTTCCCGTGTAAATATAGTATTCAAGCAATA
ATAATTCAAGTTGGCAATGCTATTTCTGCATATGGCAATCTGATGTCGTA
TGTTGGATCTACAGCGATTAGTGCAATATGGTTTCCTACGGCTGAGAGAT
CACGTTCAACTTGCACTGCGCTAGCTTTCAGTACTCTTGGATCCGTAATG
GCTCCGATTGTCGGTAACGATATAAAAGTTGATAGATGCAACAATAATGA
CAACAAAAGATCACATACATTTGCCTTAATTTGAATGGATTTTATTTTCA
GGTACACGAATTGTACCAACATTCTCCGGAAACGGAACAAACACTCCTGA
AAACAAAGAAAAGATCCATTTAGGCATGCAACAGTTTATGTTTTTTCATT
GCTCCATTGCTCTTACTACTGTTTTACTAATTATTATATATTTTCCTTCA
AAGCCGAAGTATATGCCTTGTAAATCCTCTGAAAAATCTCTTCGGATTGA
TCTCAAATCTGGATGTATTGAATTAGCAAAAAATAAGCAATTCTGGATAA
TCTTTCTCCTTAATTTCATTACATCTGGATTCAATTCTGGCGTAGTGTCA
GTTCTGCCTTCAATCATTGAGCCGCTTGGTGTTACTCAGTTAGAAACGGC
CACATTGGTATCAGTGGGAAATTTATGTGTTTTTATTAGCTCTATTATTG
GAGGGATTCTCGGTGATAAATTTAGTTACAAAAAAATTGTAATCCTATCA
ATTCCTCCGACTATAGTTACATACGTTTTGTTTGGGTTGCAGTCTATGAA
GATTATTCGTCATGAACTTGGAGTCATCTATGCAGTTCTCCTTACTATGC
TTTTTGTTTCAAACATTATATCAAATATTTCTTTCGAAATGGGCTGTGAA
GTTTCGTTTCCTACGGGTGAGGAAGTTACCACTGCGGTTTTGGGATTCGC
AACTAATCTTGGAATAGTCGTAATTCTCTCTGTTACCATGATAACTGATA
AAAATGTCACATGGATACCGTTTGCCTATGGCGCAGCAGTTTTATTGGTG
CTACCTTTCATGTTTTTCTATAAGGACGAACGAAAACGCTTCAACTGTGA
CTTCGGGGCTCCTCCTAACTCATGCCTTGAAGTAAATGAAGATATTGAAG
CTGAACGTCTTTGCAGTGATTCTTCGAATGAAGAAATAGGCAATGAGAGC
GAAGATGAATATAAAAATGTCGATTATTCTAGTTTAAGATTTCTAAGCTA
GCGATATTTGAAATGACAATGAGTTTATATTTTTG
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protein sequence of SMED30034544-orf-1

>SMED30034544-orf-1 ID=SMED30034544-orf-1|Name=SMED30034544-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=292bp
MQQFMFFHCSIALTTVLLIIIYFPSKPKYMPCKSSEKSLRIDLKSGCIEL
AKNKQFWIIFLLNFITSGFNSGVVSVLPSIIEPLGVTQLETATLVSVGNL
CVFISSIIGGILGDKFSYKKIVILSIPPTIVTYVLFGLQSMKIIRHELGV
IYAVLLTMLFVSNIISNISFEMGCEVSFPTGEEVTTAVLGFATNLGIVVI
LSVTMITDKNVTWIPFAYGAAVLLVLPFMFFYKDERKRFNCDFGAPPNSC
LEVNEDIEAERLCSDSSNEEIGNESEDEYKNVDYSSLRFLS*
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protein sequence of SMED30034544-orf-2

>SMED30034544-orf-2 ID=SMED30034544-orf-2|Name=SMED30034544-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=189bp
MESEDKRIIYKPLKRRFYILFSFCIYSFTGGIIWNSWQPLIKSINELYLW
SNTEVNLLNNINAIVVCSLIFPFIILWNKCGIKFAYTTSSCIVLLGCLIR
VFPCKYSIQAIIIQVGNAISAYGNLMSYVGSTAISAIWFPTAERSRSTCT
ALAFSTLGSVMAPIVGNDIKVDRCNNNDNKRSHTFALI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0022857transmembrane transporter activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036259MFS_trans_sf
IPR020846MFS_dom
IPR011701MFS
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
Vocabulary: biological process
TermDefinition
GO:0055085transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011701Major facilitator superfamilyPFAMPF07690MFS_1coord: 8..160
e-value: 5.6E-11
score: 42.0
NoneNo IPR availableGENE3DG3DSA:1.20.1250.20coord: 49..239
e-value: 9.4E-18
score: 66.3
NoneNo IPR availablePANTHERPTHR10924MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATEDcoord: 4..242
NoneNo IPR availableCDDcd17397MFS_DIRC2coord: 4..228
e-value: 2.15741E-29
score: 112.777
NoneNo IPR availableTMHMMTMhelixcoord: 59..81
NoneNo IPR availableTMHMMTMhelixcoord: 210..232
NoneNo IPR availableTMHMMTMhelixcoord: 4..23
NoneNo IPR availableTMHMMTMhelixcoord: 184..206
NoneNo IPR availableTMHMMTMhelixcoord: 149..171
NoneNo IPR availableTMHMMTMhelixcoord: 120..139
NoneNo IPR availableTMHMMTMhelixcoord: 91..113
IPR036259MFS transporter superfamilySUPERFAMILYSSF103473MFS general substrate transportercoord: 5..238