early growth response-2

Overview
Nameearly growth response-2 (AFJ24725.1)
Smed IDSMED30034500
Length (bp)1636
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of early growth response-2 (SMED30034500) t-SNE clustered cells

Violin plots show distribution of expression levels for early growth response-2 (SMED30034500) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of early growth response-2 (SMED30034500) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for early growth response-2 (SMED30034500) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034500

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30034500SMESG000004840.1 dd_Smed_v4_9273_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
central nervous systemSMED30034500SMESG000004840.1 JX010482.1smed_ncbi_20200123PMID:25254346
Scimone et al., 2014		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of early growth response-2 vs. Ensembl Human
Match: EGR4 (early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241])

HSP 1 Score: 130.183 bits (326), Expect = 5.804e-32
Identity = 54/85 (63.53%), Postives = 64/85 (75.29%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  378 KAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 462
[Close]
BLAST of early growth response-2 vs. Ensembl Human
Match: EGR4 (early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241])

HSP 1 Score: 129.798 bits (325), Expect = 2.441e-31
Identity = 54/85 (63.53%), Postives = 64/85 (75.29%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  481 KAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 565
[Close]
BLAST of early growth response-2 vs. Ensembl Human
Match: EGR1 (early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238])

HSP 1 Score: 128.257 bits (321), Expect = 4.917e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  ESC R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R +
Sbjct:  335 ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK 422
[Close]
BLAST of early growth response-2 vs. Ensembl Human
Match: EGR3 (early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240])

HSP 1 Score: 122.094 bits (305), Expect = 1.108e-29
Identity = 54/99 (54.55%), Postives = 67/99 (67.68%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR-------GLSRISTAP 1011
            C  E C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H + +       G    S+AP
Sbjct:  277 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAP 375

HSP 2 Score: 64.3142 bits (155), Expect = 1.801e-10
Identity = 29/59 (49.15%), Postives = 37/59 (62.71%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP+ CEFC +KFARSD  K H + H  ++
Sbjct:  303 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQK 359
[Close]
BLAST of early growth response-2 vs. Ensembl Human
Match: EGR3 (early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240])

HSP 1 Score: 120.553 bits (301), Expect = 1.727e-29
Identity = 54/99 (54.55%), Postives = 67/99 (67.68%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR-------GLSRISTAP 1011
            C  E C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H + +       G    S+AP
Sbjct:  239 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAP 337

HSP 2 Score: 63.929 bits (154), Expect = 2.365e-10
Identity = 29/59 (49.15%), Postives = 37/59 (62.71%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP+ CEFC +KFARSD  K H + H  ++
Sbjct:  265 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQK 321
[Close]
BLAST of early growth response-2 vs. Ensembl Celegans
Match: egrh-2 (EGR (Early Growth factor Response factor) Homolog [Source:UniProtKB/TrEMBL;Acc:U4PM44])

HSP 1 Score: 113.62 bits (283), Expect = 1.230e-29
Identity = 49/98 (50.00%), Postives = 70/98 (71.43%), Query Frame = 1 
Query:  730 FICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR-GRGLSRISTAPEFE 1020
            + C  + C +KF+RSDEL RH+R+H+G KP+ C  C ++F+RSDHL TH RTHTGE+P+ C++C KKFAR DE++RH K H + G G  ++   P + 
Sbjct:   13 YKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSGPGKHKMKCGPPWR 110

HSP 2 Score: 65.4698 bits (158), Expect = 1.111e-12
Identity = 30/62 (48.39%), Postives = 44/62 (70.97%), Query Frame = 1 
Query:  796 RVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            ++H   +PY C  + C KKF+RSD L  H R HTG++PF+C +C ++F+RSD  + HV+THT
Sbjct:    5 KMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHT 66
[Close]
BLAST of early growth response-2 vs. Ensembl Celegans
Match: egrh-2 (EGR (Early Growth factor Response factor) Homolog [Source:UniProtKB/TrEMBL;Acc:U4PM44])

HSP 1 Score: 117.857 bits (294), Expect = 2.223e-29
Identity = 49/99 (49.49%), Postives = 71/99 (71.72%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR-GRGLSRISTAPEF 1017
            + + C  + C +KF+RSDEL RH+R+H+G KP+ C  C ++F+RSDHL TH RTHTGE+P+ C++C KKFAR DE++RH K H + G G  ++   P +
Sbjct:  176 RPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSGPGKHKMKCGPPW 274

HSP 2 Score: 68.9366 bits (167), Expect = 1.354e-12
Identity = 30/62 (48.39%), Postives = 44/62 (70.97%), Query Frame = 1 
Query:  796 RVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            ++H   +PY C  + C KKF+RSD L  H R HTG++PF+C +C ++F+RSD  + HV+THT
Sbjct:  170 KMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHT 231
[Close]
BLAST of early growth response-2 vs. Ensembl Celegans
Match: egrh-2 (EGR (Early Growth factor Response factor) Homolog [Source:UniProtKB/TrEMBL;Acc:U4PM44])

HSP 1 Score: 111.694 bits (278), Expect = 3.599e-29
Identity = 46/83 (55.42%), Postives = 64/83 (77.11%), Query Frame = 1 
Query:  730 FICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            + C  + C +KF+RSDEL RH+R+H+G KP+ C  C ++F+RSDHL TH RTHTGE+P+ C++C KKFAR DE++RH K H +
Sbjct:   13 YKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKK 95

HSP 2 Score: 67.0106 bits (162), Expect = 2.713e-13
Identity = 37/95 (38.95%), Postives = 55/95 (57.89%), Query Frame = 1 
Query:  796 RVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRS 1074
            ++H   +PY C  + C KKF+RSD L  H R HTG++PF+C +C ++F+RSD  + HV+THT  +  S      +F   D +   T+   K  RS
Sbjct:    5 KMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSQRS 99
[Close]
BLAST of early growth response-2 vs. Ensembl Celegans
Match: egrh-2 (EGR (Early Growth factor Response factor) Homolog [Source:UniProtKB/TrEMBL;Acc:U4PM44])

HSP 1 Score: 116.701 bits (291), Expect = 5.385e-29
Identity = 46/85 (54.12%), Postives = 65/85 (76.47%), Query Frame = 1 
Query:  730 FICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            + C  + C +KF+RSDEL RH+R+H+G KP+ C  C ++F+RSDHL TH RTHTGE+P+ C++C KKFAR DE++RH K H + +
Sbjct:  178 YKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSQ 262

HSP 2 Score: 69.3218 bits (168), Expect = 7.486e-13
Identity = 37/95 (38.95%), Postives = 55/95 (57.89%), Query Frame = 1 
Query:  796 RVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRS 1074
            ++H   +PY C  + C KKF+RSD L  H R HTG++PF+C +C ++F+RSD  + HV+THT  +  S      +F   D +   T+   K  RS
Sbjct:  170 KMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSQRS 264
[Close]
BLAST of early growth response-2 vs. Ensembl Celegans
Match: egrh-1 (EGR (Early Growth factor Response factor) Homolog [Source:UniProtKB/TrEMBL;Acc:Q18250])

HSP 1 Score: 119.783 bits (299), Expect = 6.060e-29
Identity = 49/90 (54.44%), Postives = 65/90 (72.22%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLS 993
            + + C  + C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H   R  S
Sbjct:  372 RPYKCPRDGCDRRFSRSDELTRHIRIHTGQKPFQCRICMRAFSRSDHLTTHVRTHTGEKPFSCDICGRKFARSDERKRHTKVHKTSRSGS 461
[Close]
BLAST of early growth response-2 vs. Ensembl Fly
Match: sr (gene:FBgn0003499 transcript:FBtr0083542)

HSP 1 Score: 129.028 bits (323), Expect = 5.885e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDEK RH K H + R
Sbjct: 1033 ERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQR 1120
[Close]
BLAST of early growth response-2 vs. Ensembl Fly
Match: sr (gene:FBgn0003499 transcript:FBtr0330050)

HSP 1 Score: 129.028 bits (323), Expect = 6.322e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDEK RH K H + R
Sbjct: 1033 ERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQR 1120
[Close]
BLAST of early growth response-2 vs. Ensembl Fly
Match: sr (gene:FBgn0003499 transcript:FBtr0301615)

HSP 1 Score: 127.872 bits (320), Expect = 8.253e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDEK RH K H + R
Sbjct:  564 ERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQR 651
[Close]
BLAST of early growth response-2 vs. Ensembl Fly
Match: sr (gene:FBgn0003499 transcript:FBtr0344633)

HSP 1 Score: 127.487 bits (319), Expect = 1.427e-30
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDEK RH K H + R
Sbjct:  753 ERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQR 840
[Close]
BLAST of early growth response-2 vs. Ensembl Fly
Match: sr (gene:FBgn0003499 transcript:FBtr0083543)

HSP 1 Score: 127.487 bits (319), Expect = 1.427e-30
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDEK RH K H + R
Sbjct:  753 ERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQR 840
[Close]
BLAST of early growth response-2 vs. Ensembl Zebrafish
Match: egr4 (early growth response 4 [Source:ZFIN;Acc:ZDB-GENE-080204-90])

HSP 1 Score: 127.102 bits (318), Expect = 5.734e-32
Identity = 53/91 (58.24%), Postives = 70/91 (76.92%), Query Frame = 1 
Query:  712 AKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            A  +K F C  ESC R+F+RSDELNRH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDE+ RH++ H + R
Sbjct:  244 AAREKPFSCPVESCERRFSRSDELNRHVRIHTGHKPFQCRVCLRCFSRSDHLTTHMRTHTGEKPFSCDVCARRFARSDERKRHMRVHLKQR 334
[Close]
BLAST of early growth response-2 vs. Ensembl Zebrafish
Match: egr1 (early growth response 1 [Source:NCBI gene;Acc:30498])

HSP 1 Score: 128.642 bits (322), Expect = 2.171e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE+C +KFARSDE+ RH K H R +
Sbjct:  308 ERPYACPVETCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHMRQK 395
[Close]
BLAST of early growth response-2 vs. Ensembl Zebrafish
Match: egr1 (early growth response 1 [Source:NCBI gene;Acc:30498])

HSP 1 Score: 128.642 bits (322), Expect = 2.171e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE+C +KFARSDE+ RH K H R +
Sbjct:  308 ERPYACPVETCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHMRQK 395
[Close]
BLAST of early growth response-2 vs. Ensembl Zebrafish
Match: egr3 (early growth response 3 [Source:ZFIN;Acc:ZDB-GENE-040718-394])

HSP 1 Score: 121.324 bits (303), Expect = 1.969e-29
Identity = 50/81 (61.73%), Postives = 62/81 (76.54%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            C  E+C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H +
Sbjct:  299 CPAENCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCEFCGRKFARSDERKRHAKVHLK 379

HSP 2 Score: 65.0846 bits (157), Expect = 8.639e-11
Identity = 30/74 (40.54%), Postives = 44/74 (59.46%), Query Frame = 1 
Query:  754 RRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            R+  NR  +   H R H+       E C ++F+RSD L  H R HTG +PF+C +C + F+RSD  + H++THT
Sbjct:  281 RKYPNRPSKTPVHERPHA----CPAENCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHT 350

HSP 3 Score: 64.3142 bits (155), Expect = 1.333e-10
Identity = 29/59 (49.15%), Postives = 38/59 (64.41%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP++CEFC +KFARSD  K H + H  ++
Sbjct:  325 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFSCEFCGRKFARSDERKRHAKVHLKQK 381
[Close]
BLAST of early growth response-2 vs. Ensembl Zebrafish
Match: egr2a (early growth response 2a [Source:ZFIN;Acc:ZDB-GENE-030723-6])

HSP 1 Score: 116.701 bits (291), Expect = 3.128e-29
Identity = 49/86 (56.98%), Postives = 64/86 (74.42%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            ++ + C  E C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+ C +KFARSDE+ RH K H R
Sbjct:  145 ERPYPCPAEGCDRRFSRSDELTRHVRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDFCGRKFARSDERRRHTKIHQR 230

HSP 2 Score: 64.6994 bits (156), Expect = 3.334e-11
Identity = 29/66 (43.94%), Postives = 42/66 (63.64%), Query Frame = 1 
Query:  784 NRHLRVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            NR  +     +PY C  E C ++F+RSD L  H R HTG +PF+C +C + F+RSD  + H++THT
Sbjct:  136 NRPCKTPVHERPYPCPAEGCDRRFSRSDELTRHVRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHT 201
[Close]
BLAST of early growth response-2 vs. Ensembl Xenopus
Match: egr1 (early growth response 1 [Source:NCBI gene;Acc:100038164])

HSP 1 Score: 128.257 bits (321), Expect = 2.096e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  ESC R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R +
Sbjct:  277 ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK 364
[Close]
BLAST of early growth response-2 vs. Ensembl Xenopus
Match: egr1 (early growth response 1 [Source:NCBI gene;Acc:100038164])

HSP 1 Score: 128.642 bits (322), Expect = 2.526e-31
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  ESC R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R +
Sbjct:  304 ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK 391
[Close]
BLAST of early growth response-2 vs. Ensembl Xenopus
Match: usp31 (ubiquitin specific peptidase 31 [Source:Xenbase;Acc:XB-GENE-920956])

HSP 1 Score: 125.176 bits (313), Expect = 5.992e-30
Identity = 53/89 (59.55%), Postives = 66/89 (74.16%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRG 987
            +K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C ++FARSDEK RH K H + + 
Sbjct:  437 EKAFACPVESCIRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHIRTHTGEKPFSCDLCGRRFARSDEKKRHGKVHMKQKA 525
[Close]
BLAST of early growth response-2 vs. Ensembl Xenopus
Match: tbl1x (transducin beta like 1 X-linked [Source:Xenbase;Acc:XB-GENE-982285])

HSP 1 Score: 120.553 bits (301), Expect = 4.081e-29
Identity = 51/96 (53.12%), Postives = 68/96 (70.83%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTA 1008
            ++ + C  E C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+ C +KFARSDE+ RH K H R +     +TA
Sbjct:  258 ERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKNSATA 353
[Close]
BLAST of early growth response-2 vs. Ensembl Xenopus
Match: serpinb4 (serpin peptidase inhibitor, clade B (ovalbumin), member 4 [Source:Xenbase;Acc:XB-GENE-5787878])

HSP 1 Score: 119.013 bits (297), Expect = 9.901e-29
Identity = 49/79 (62.03%), Postives = 60/79 (75.95%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTH 972
            C  E C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+ C +KFARSDE+ RH K H
Sbjct:  274 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHAKIH 352

HSP 2 Score: 62.3882 bits (150), Expect = 8.297e-10
Identity = 35/92 (38.04%), Postives = 45/92 (48.91%), Query Frame = 1 
Query:  658 SKTISYSTPRSCSSSGS---------------IAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTH 888
            SKT  +  P +C + G                I    K F C    C R F+RSD L  H+R H+G KP+ C+FC +KFARSD  K H + H
Sbjct:  263 SKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHAKIH 352
[Close]
BLAST of early growth response-2 vs. Ensembl Mouse
Match: Egr4 (early growth response 4 [Source:MGI Symbol;Acc:MGI:99252])

HSP 1 Score: 130.954 bits (328), Expect = 2.562e-32
Identity = 54/85 (63.53%), Postives = 64/85 (75.29%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  370 KAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 454
[Close]
BLAST of early growth response-2 vs. Ensembl Mouse
Match: Egr1 (early growth response 1 [Source:MGI Symbol;Acc:MGI:95295])

HSP 1 Score: 128.642 bits (322), Expect = 2.511e-31
Identity = 71/180 (39.44%), Postives = 101/180 (56.11%), Query Frame = 1 
Query:  448 FQLETDPVFMGYSSQLSKICL--DDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKP-KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            FQ+   P ++ +  Q   + L   D  P    +N T +PS +     P+   K   T    +   + +T   S+ I  S  R   +  S   P ++ + C  ESC R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R
Sbjct:  245 FQVPMIPDYL-FPQQQGDLSLGTPDQKPFQGLENRTQQPSLT-----PLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR 418
[Close]
BLAST of early growth response-2 vs. Ensembl Mouse
Match: Egr1 (early growth response 1 [Source:MGI Symbol;Acc:MGI:95295])

HSP 1 Score: 128.642 bits (322), Expect = 2.511e-31
Identity = 71/180 (39.44%), Postives = 101/180 (56.11%), Query Frame = 1 
Query:  448 FQLETDPVFMGYSSQLSKICL--DDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKP-KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            FQ+   P ++ +  Q   + L   D  P    +N T +PS +     P+   K   T    +   + +T   S+ I  S  R   +  S   P ++ + C  ESC R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R
Sbjct:  245 FQVPMIPDYL-FPQQQGDLSLGTPDQKPFQGLENRTQQPSLT-----PLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR 418
[Close]
BLAST of early growth response-2 vs. Ensembl Mouse
Match: Egr3 (early growth response 3 [Source:MGI Symbol;Acc:MGI:1306780])

HSP 1 Score: 122.094 bits (305), Expect = 7.460e-30
Identity = 54/99 (54.55%), Postives = 67/99 (67.68%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR-------GLSRISTAP 1011
            C  E C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H + +       G    S+AP
Sbjct:  277 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAP 375

HSP 2 Score: 64.6994 bits (156), Expect = 1.214e-10
Identity = 29/59 (49.15%), Postives = 37/59 (62.71%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP+ CEFC +KFARSD  K H + H  ++
Sbjct:  303 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQK 359
[Close]
BLAST of early growth response-2 vs. Ensembl Mouse
Match: Egr3 (early growth response 3 [Source:MGI Symbol;Acc:MGI:1306780])

HSP 1 Score: 120.939 bits (302), Expect = 1.076e-29
Identity = 54/99 (54.55%), Postives = 67/99 (67.68%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR-------GLSRISTAP 1011
            C  E C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H + +       G    S+AP
Sbjct:  239 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAP 337

HSP 2 Score: 63.929 bits (154), Expect = 1.566e-10
Identity = 29/59 (49.15%), Postives = 37/59 (62.71%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP+ CEFC +KFARSD  K H + H  ++
Sbjct:  265 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQK 321
[Close]
BLAST of early growth response-2 vs. UniProt/SwissProt
Match: sp|Q9WUF2|EGR4_MOUSE (Early growth response protein 4 OS=Mus musculus OX=10090 GN=Egr4 PE=3 SV=1)

HSP 1 Score: 130.954 bits (328), Expect = 1.792e-31
Identity = 54/85 (63.53%), Postives = 64/85 (75.29%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  370 KAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 454
[Close]
BLAST of early growth response-2 vs. UniProt/SwissProt
Match: sp|Q00911|EGR4_RAT (Early growth response protein 4 OS=Rattus norvegicus OX=10116 GN=Egr4 PE=2 SV=1)

HSP 1 Score: 130.568 bits (327), Expect = 2.070e-31
Identity = 54/85 (63.53%), Postives = 64/85 (75.29%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  370 KAFACPVESCVRTFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 454
[Close]
BLAST of early growth response-2 vs. UniProt/SwissProt
Match: sp|Q9GL32|EGR4_BOVIN (Early growth response protein 4 OS=Bos taurus OX=9913 GN=EGR4 PE=2 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 3.099e-31
Identity = 54/86 (62.79%), Postives = 64/86 (74.42%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
             K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  373 AKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 458
[Close]
BLAST of early growth response-2 vs. UniProt/SwissProt
Match: sp|Q05215|EGR4_HUMAN (Early growth response protein 4 OS=Homo sapiens OX=9606 GN=EGR4 PE=1 SV=3)

HSP 1 Score: 129.798 bits (325), Expect = 1.172e-30
Identity = 54/85 (63.53%), Postives = 64/85 (75.29%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            K F C  ESC R F RSDELNRHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+VC ++FARSDEK RH K H +
Sbjct:  481 KAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLK 565
[Close]
BLAST of early growth response-2 vs. UniProt/SwissProt
Match: sp|A4II20|EGR1_XENTR (Early growth response protein 1 OS=Xenopus tropicalis OX=8364 GN=egr1 PE=2 SV=2)

HSP 1 Score: 128.642 bits (322), Expect = 1.338e-30
Identity = 50/88 (56.82%), Postives = 67/88 (76.14%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++ + C  ESC R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R +
Sbjct:  304 ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK 391
[Close]
BLAST of early growth response-2 vs. TrEMBL
Match: I1ZI71 (Early growth response-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 403.675 bits (1036), Expect = 3.145e-136
Identity = 195/203 (96.06%), Postives = 196/203 (96.55%), Query Frame = 1 
Query:  448 FQLETDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKR 1056
            F  +    FMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVC KKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKR
Sbjct:   23 FNWKRIQFFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCHKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKR 225

HSP 2 Score: 63.5438 bits (153), Expect = 1.353e-7
Identity = 29/30 (96.67%), Postives = 29/30 (96.67%), Query Frame = 2 
Query:  386 KSRLEKLKNPASDIYQLTVLVFNWKRIQFL 475
            KSRLEKLKNPASDIYQLTVLVFNWKRIQF 
Sbjct:    2 KSRLEKLKNPASDIYQLTVLVFNWKRIQFF 31
[Close]
BLAST of early growth response-2 vs. TrEMBL
Match: T1E1F4 (Egrl-2 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 349.747 bits (896), Expect = 1.225e-113
Identity = 197/339 (58.11%), Postives = 238/339 (70.21%), Query Frame = 1 
Query:   94 MSSGESPSDVDSKKMIALVGTDKLDGSELDNVKTGLTPPHKTLEFFEQQYNVENIATPMRFDXXXXXXXXXXXXXXXFTSTQGHFMKFDDDTLTSNLEIEIGEIKESGFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTS---QLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRSSDGSITYQF 1101
            M S  S  ++DSK++IALVGTDKLDGSELDNVKTGLTPP    +F++ QY VE+IATPMRF+E+E     LE    E T  Q    ++ D +     E+ I E K S F   S+   +F LE D   M YS+QLSKICLDDILPII R++ +    T     ++EE    TK +      E+ HSWD  S+S  +SY T R  SS+GSI+KPKKQF C+YE+C+RKFNRSDELNRH RVHSGIKPYTCE+CFK FARSDHLKTHRRTHTGERPFECE+C KKFARSDEKSRH +THT+GRGLS++ TAPE          ++   KEHR+SDGSITY+F
Sbjct:    1 MDSPPSTGEMDSKEIIALVGTDKLDGSELDNVKTGLTPPSHARDFYDIQYRVEDIATPMRFEEDECSPGPLEDIPGEIT--QEVVPQYRDPS--QRFEVGI-EGKRSRFALSSVKGCQFPLEKDSTSMTYSTQLSKICLDDILPIIKRESQSKSNITEFQRNIQEEDEESTKIL------EAHHSWDVASTS-YVSYPTTRQTSSTGSISKPKKQFQCSYETCKRKFNRSDELNRHTRVHSGIKPYTCEYCFKNFARSDHLKTHRRTHTGERPFECEICAKKFARSDEKSRHSRTHTKGRGLSKVFTAPESMSSQEGTSSSKPEVKEHRASDGSITYKF 327
[Close]
BLAST of early growth response-2 vs. TrEMBL
Match: A0A5K3FS57 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 5.033e-32
Identity = 82/204 (40.20%), Postives = 107/204 (52.45%), Query Frame = 1 
Query:  415 GFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINR-----DNTTGEPSTSQLKEEPIRKTKDIK----TFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRI 999
             F H S    RF++      +     LS     D+LP  +         T  PS S +K+EP     D++    + ++   R S   PS+S               S +  +KQF+CN E C ++F R DEL RH R HS I+PYTC  C K F RSDHL THRRTHTGE+P+ C  C++ FARSDE+SRHVKTHT  R  + I
Sbjct:  211 SFDHPSTSCERFEVLASRRSVSVPQTLS---CRDVLPFTSNVCAPTATQTTAPSYSVVKQEPFEFPIDVRRASCSSLTGRPRRSLFAPSTSI-------------ASASTKEKQFVCNAEGCEKRFARVDELKRHQRTHSDIRPYTCNICDKGFTRSDHLITHRRTHTGEKPYPCHYCERCFARSDERSRHVKTHTNPRPSTSI 398
[Close]
BLAST of early growth response-2 vs. TrEMBL
Match: A0A0R3U9C5 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS3523 PE=4 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 5.202e-32
Identity = 82/204 (40.20%), Postives = 107/204 (52.45%), Query Frame = 1 
Query:  415 GFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINR-----DNTTGEPSTSQLKEEPIRKTKDIK----TFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRI 999
             F H S    RF++      +     LS     D+LP  +         T  PS S +K+EP     D++    + ++   R S   PS+S               S +  +KQF+CN E C ++F R DEL RH R HS I+PYTC  C K F RSDHL THRRTHTGE+P+ C  C++ FARSDE+SRHVKTHT  R  + I
Sbjct:  202 SFDHPSTSCERFEVLASRRSVSVPQTLS---CRDVLPFTSNVCAPTATQTTAPSYSVVKQEPFEFPIDVRRASCSSLTGRPRRSLFAPSTSI-------------ASASTKEKQFVCNAEGCEKRFARVDELKRHQRTHSDIRPYTCNICDKGFTRSDHLITHRRTHTGEKPYPCHYCERCFARSDERSRHVKTHTNPRPSTSI 389
[Close]
BLAST of early growth response-2 vs. TrEMBL
Match: A0A0R3X7W5 (Uncharacterized protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS9625 PE=4 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 3.609e-31
Identity = 60/95 (63.16%), Postives = 71/95 (74.74%), Query Frame = 1 
Query:  700 SGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            S SI   +KQF+CN E C ++F R DEL RH R HS I+PYTC  C K F RSDHL THRRTHTGE+P+ C+ C++ FARSDE+SRHVKTHT  R
Sbjct:  301 STSITSKEKQFVCNAEGCEKRFARVDELKRHQRTHSDIRPYTCNICDKGFTRSDHLITHRRTHTGEKPYPCQYCERCFARSDERSRHVKTHTNPR 395
[Close]
BLAST of early growth response-2 vs. Ensembl Cavefish
Match: egr4 (early growth response protein 1-B [Source:NCBI gene;Acc:103025429])

HSP 1 Score: 130.568 bits (327), Expect = 3.024e-33
Identity = 65/162 (40.12%), Postives = 98/162 (60.49%), Query Frame = 1 
Query:  508 LDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSG---SIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            LDDI+ ++     T  P T  +K+EP+    +    +   S  +    +      ++   + S+ G   + A+ +K F C  E+C R+F+RSDELNRH+RVH+G +P+ C  C ++F RSDHL TH RTHTGE+PF C+VC ++FARSDE+ RH + H + R
Sbjct:  161 LDDIIELLAPLEPTCAPET-WIKQEPLLYADECARAIPSPSNFAAQLQTPPTLHGHALFHATSTGGRKAAGARREKPFPCPVENCERRFSRSDELNRHVRVHTGHRPFQCRVCSRRFGRSDHLTTHMRTHTGEKPFSCDVCGRRFARSDERKRHARVHIKQR 321
[Close]
BLAST of early growth response-2 vs. Ensembl Cavefish
Match: egr4 (early growth response protein 1-B [Source:NCBI gene;Acc:103025429])

HSP 1 Score: 125.176 bits (313), Expect = 4.218e-31
Identity = 52/91 (57.14%), Postives = 70/91 (76.92%), Query Frame = 1 
Query:  712 AKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            A+ +K F C  E+C R+F+RSDELNRH+RVH+G +P+ C  C ++F RSDHL TH RTHTGE+PF C+VC ++FARSDE+ RH + H + R
Sbjct:  270 ARREKPFPCPVENCERRFSRSDELNRHVRVHTGHRPFQCRVCSRRFGRSDHLTTHMRTHTGEKPFSCDVCGRRFARSDERKRHARVHIKQR 360
[Close]
BLAST of early growth response-2 vs. Ensembl Cavefish
Match: egr1 (early growth response 1 [Source:NCBI gene;Acc:103036296])

HSP 1 Score: 127.102 bits (318), Expect = 5.283e-31
Identity = 50/86 (58.14%), Postives = 66/86 (76.74%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE+C +KFARSDE+ RH K H R
Sbjct:  315 ERPYACPVETCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHLR 400
[Close]
BLAST of early growth response-2 vs. Ensembl Cavefish
Match: EGR2 (early growth response protein 2b-like [Source:NCBI gene;Acc:103032442])

HSP 1 Score: 121.709 bits (304), Expect = 8.666e-30
Identity = 53/99 (53.54%), Postives = 69/99 (69.70%), Query Frame = 1 
Query:  682 PRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            PR+C +       ++ + C  E C R+F+RSDEL RH+RVH+G KP+ C  C + F RSDHL TH RTHTGE+PF C++C +KFARSDE+ RH K H R
Sbjct:  265 PRACKTPVH----ERPYPCPAEGCDRRFSRSDELARHVRVHTGHKPFQCRICMRSFGRSDHLTTHIRTHTGEKPFACDLCGRKFARSDERRRHAKIHQR 359
[Close]
BLAST of early growth response-2 vs. Ensembl Cavefish
Match: egr3 (early growth response 3 [Source:NCBI gene;Acc:103035480])

HSP 1 Score: 121.709 bits (304), Expect = 1.379e-29
Identity = 50/81 (61.73%), Postives = 62/81 (76.54%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            C  E+C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H +
Sbjct:  304 CPAENCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCEFCGRKFARSDERKRHAKVHLK 384

HSP 2 Score: 64.6994 bits (156), Expect = 8.575e-11
Identity = 29/59 (49.15%), Postives = 38/59 (64.41%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP++CEFC +KFARSD  K H + H  ++
Sbjct:  330 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFSCEFCGRKFARSDERKRHAKVHLKQK 386
[Close]
BLAST of early growth response-2 vs. Ensembl Sea Lamprey
Match: egr4 (early growth response 4 [Source:ZFIN;Acc:ZDB-GENE-080204-90])

HSP 1 Score: 122.479 bits (306), Expect = 9.756e-32
Identity = 49/87 (56.32%), Postives = 66/87 (75.86%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            + F C  E C R+F+R+DEL RH+R+H+G KP+TC  C + F+RSDHL TH RTHTGE+PF C+ C ++FARSDE+ RH + H +GR
Sbjct:  170 RPFPCPAEGCDRRFSRTDELTRHIRIHTGHKPFTCRICMRSFSRSDHLTTHVRTHTGEKPFACDFCGRRFARSDERKRHGRIHLKGR 256

HSP 2 Score: 63.5438 bits (153), Expect = 1.717e-11
Identity = 28/66 (42.42%), Postives = 41/66 (62.12%), Query Frame = 1 
Query:  784 NRHLRVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            NR  +     +P+ C  E C ++F+R+D L  H R HTG +PF C +C + F+RSD  + HV+THT
Sbjct:  160 NRPCKTPPHARPFPCPAEGCDRRFSRTDELTRHIRIHTGHKPFTCRICMRSFSRSDHLTTHVRTHT 225
[Close]
BLAST of early growth response-2 vs. Ensembl Sea Lamprey
Match: wt1a (WT1 transcription factor a [Source:ZFIN;Acc:ZDB-GENE-980526-558])

HSP 1 Score: 101.293 bits (251), Expect = 4.747e-24
Identity = 52/94 (55.32%), Postives = 66/94 (70.21%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGI---KPYTCEFCFKKFARSDHLKTHRRTHTG---ERPFECEV--CQKKFARSDEKSRHVKTHTR 978
            ++ + C+Y+ C R+F+RSD+L RH R H+G+   KP+ C+ C +KFARSDHLKTH RTHTG   E+PF C    CQKKFARSDE  RH   H R
Sbjct:  198 ERPYQCDYKDCGRRFSRSDQLKRHQRRHTGVTGVKPFQCKMCDRKFARSDHLKTHTRTHTGKPSEKPFVCRWPNCQKKFARSDELVRHHNMHQR 291

HSP 2 Score: 86.6557 bits (213), Expect = 3.927e-19
Identity = 40/99 (40.40%), Postives = 63/99 (63.64%), Query Frame = 1 
Query:  694 SSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEF--CFKKFARSDHLKTHRRTH---TGERPFECEVCQKKFARSDEKSRHVKTHT 975
            + SG     ++ ++CNY  C +++ +   L  H R H+G +PY C++  C ++F+RSD LK H+R H   TG +PF+C++C +KFARSD    H +THT
Sbjct:  159 APSGRGRADRRPYMCNYPGCSKRYFKLSHLQMHCRKHTGERPYQCDYKDCGRRFSRSDQLKRHQRRHTGVTGVKPFQCKMCDRKFARSDHLKTHTRTHT 257

HSP 3 Score: 56.6102 bits (135), Expect = 4.641e-9
Identity = 26/63 (41.27%), Postives = 41/63 (65.08%), Query Frame = 1 
Query:  814 KPYTCEF--CFKKFARSDHLKTHRRTHTGERPFECEV--CQKKFARSDEKSRHVKTHTRGRGL 990
            +PY C +  C K++ +  HL+ H R HTGERP++C+   C ++F+RSD+  RH + HT   G+
Sbjct:  169 RPYMCNYPGCSKRYFKLSHLQMHCRKHTGERPYQCDYKDCGRRFSRSDQLKRHQRRHTGVTGV 231
[Close]
BLAST of early growth response-2 vs. Ensembl Sea Lamprey
Match: sp4 (sp4 transcription factor [Source:ZFIN;Acc:ZDB-GENE-031202-3])

HSP 1 Score: 98.9821 bits (245), Expect = 7.836e-23
Identity = 44/93 (47.31%), Postives = 60/93 (64.52%), Query Frame = 1 
Query:  700 SGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCE--FCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTH 972
            SGS    KKQ +C+   C + + ++  L  HLR H+G +P+ C   FC K+F RSD L+ HRRTHTGE+ F C  C K+F RSD  S+H++TH
Sbjct:  284 SGSEPGKKKQHVCHIPGCSKVYGKTSHLRAHLRWHTGERPFVCGWLFCGKRFTRSDELQRHRRTHTGEKKFPCPHCSKRFMRSDHLSKHIRTH 376

HSP 2 Score: 58.9214 bits (141), Expect = 1.213e-9
Identity = 28/58 (48.28%), Postives = 35/58 (60.34%), Query Frame = 1 
Query:  814 KPYTCEF--CFKKFARSDHLKTHRRTHTGERPFECE--VCQKKFARSDEKSRHVKTHT 975
            K + C    C K + ++ HL+ H R HTGERPF C    C K+F RSDE  RH +THT
Sbjct:  292 KQHVCHIPGCSKVYGKTSHLRAHLRWHTGERPFVCGWLFCGKRFTRSDELQRHRRTHT 349
[Close]
BLAST of early growth response-2 vs. Ensembl Sea Lamprey
Match: sp4 (sp4 transcription factor [Source:ZFIN;Acc:ZDB-GENE-031202-3])

HSP 1 Score: 100.138 bits (248), Expect = 8.851e-23
Identity = 44/93 (47.31%), Postives = 60/93 (64.52%), Query Frame = 1 
Query:  700 SGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCE--FCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTH 972
            SGS    KKQ +C+   C + + ++  L  HLR H+G +P+ C   FC K+F RSD L+ HRRTHTGE+ F C  C K+F RSD  S+H++TH
Sbjct:  328 SGSEPGKKKQHVCHIPGCSKVYGKTSHLRAHLRWHTGERPFVCGWLFCGKRFTRSDELQRHRRTHTGEKKFPCPHCSKRFMRSDHLSKHIRTH 420

HSP 2 Score: 60.077 bits (144), Expect = 6.533e-10
Identity = 28/58 (48.28%), Postives = 35/58 (60.34%), Query Frame = 1 
Query:  814 KPYTCEF--CFKKFARSDHLKTHRRTHTGERPFECE--VCQKKFARSDEKSRHVKTHT 975
            K + C    C K + ++ HL+ H R HTGERPF C    C K+F RSDE  RH +THT
Sbjct:  336 KQHVCHIPGCSKVYGKTSHLRAHLRWHTGERPFVCGWLFCGKRFTRSDELQRHRRTHT 393
[Close]
BLAST of early growth response-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008916.1 (pep scaffold:Pmarinus_7.0:GL476670:39536:47416:-1 gene:ENSPMAG00000008063.1 transcript:ENSPMAT00000008916.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 100.908 bits (250), Expect = 1.078e-22
Identity = 44/93 (47.31%), Postives = 60/93 (64.52%), Query Frame = 1 
Query:  712 AKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEF--CFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            A  KKQ IC+   C + + ++  L  HLR HSG +P+ C +  C K+F RSD L+ H+RTHTGE+ F C  C K+F RSD  S+H+KTH+  R
Sbjct:  580 AGQKKQHICHITGCSKVYGKTSHLRAHLRWHSGERPFVCTWLHCGKRFTRSDELQRHKRTHTGEKKFICSECSKRFMRSDHLSKHMKTHSAKR 672
[Close]
BLAST of early growth response-2 vs. Ensembl Yeast
Match: AZF1 (Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000005639])

HSP 1 Score: 90.1225 bits (222), Expect = 2.434e-19
Identity = 39/100 (39.00%), Postives = 60/100 (60.00%), Query Frame = 1 
Query:  703 GSIAKPK--------KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            G + KPK        K+  C Y  C R F+++  L  H+R H G KP+ C++C K+F +  +L+TH R HTGE+P+ C++C KKF+R    + H+ TH +
Sbjct:  576 GGVEKPKGTQNTRAVKKHECPY--CHRLFSQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQK 673

HSP 2 Score: 68.5514 bits (166), Expect = 1.375e-12
Identity = 32/81 (39.51%), Postives = 45/81 (55.56%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFEC--EVCQKKFARSDEKSRH 960
            K F+C+Y  C ++F +   L  H R+H+G KPY+C+ C KKF+R  +L  H  TH   +PF C  E C K F +      H
Sbjct:  619 KPFVCDY--CGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAH 697
[Close]
BLAST of early growth response-2 vs. Ensembl Yeast
Match: ZAP1 (Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains [Source:SGD;Acc:S000003592])

HSP 1 Score: 86.6557 bits (213), Expect = 2.469e-18
Identity = 43/129 (33.33%), Postives = 70/129 (54.26%), Query Frame = 1 
Query:  709 IAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRSSDGSITY 1095
            + + K ++ C +  C R F +  +L RHL+VHS  KPY C+ C + F+  + L  H RTH+GE+P++C +C KKFA S     H++THT  + L        F      +   +   K+++ SD S ++
Sbjct:  731 LTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHSGEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLSKHIKTHQKKYKCSDCSKSF 859
[Close]
BLAST of early growth response-2 vs. Ensembl Yeast
Match: MSN2 (Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress [Source:SGD;Acc:S000004640])

HSP 1 Score: 75.0998 bits (183), Expect = 1.009e-14
Identity = 31/56 (55.36%), Postives = 39/56 (69.64%), Query Frame = 1 
Query:  814 KPYTCEFCFKKFARSDHLKTH-RRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            KP+ C  C K F RS+HLK H R  H+ ERPF C +C KKF+RSD  S+H+KTH +
Sbjct:  645 KPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTHKK 700

HSP 2 Score: 55.8398 bits (133), Expect = 9.940e-9
Identity = 27/57 (47.37%), Postives = 37/57 (64.91%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLR-VHSGIKPYTCEFCFKKFARSDHLKTHRRTH 888
            +K F C+   C + F RS+ L RH+R VHS  +P+ C  C KKF+RSD+L  H +TH
Sbjct:  644 EKPFHCHI--CPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTH 698
[Close]
BLAST of early growth response-2 vs. Ensembl Yeast
Match: FZF1 (Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003223])

HSP 1 Score: 72.7886 bits (177), Expect = 1.226e-14
Identity = 41/117 (35.04%), Postives = 62/117 (52.99%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCE--FCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGL-SRISTAPEFEPGDTQNPETEKRDKE 1065
            + + C+++ C + +NR   L +H   H+  KPY C+   C KKF R  HL+ H+ TH+  +P  C +CQK+F  + +  RH+ +H R   L SRI    E   G   N + E   KE
Sbjct:   10 RNYKCSFDGCEKVYNRPSLLQQHQNSHTNQKPYHCDEPGCGKKFIRPCHLRVHKWTHSQIKPKACTLCQKRFVTNQQLRRHLNSHERKSKLASRIDRKHE---GVNANVKAELNGKE 123
[Close]
BLAST of early growth response-2 vs. Ensembl Yeast
Match: MIG3 (Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genesenvironment [Source:SGD;Acc:S000000830])

HSP 1 Score: 71.2478 bits (173), Expect = 8.003e-14
Identity = 33/64 (51.56%), Postives = 43/64 (67.19%), Query Frame = 1 
Query:  814 KPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEV--CQKKFARSDEKSRHVKTHTRGRGLSRI 999
            +P+ CE C + F R +H K H RTHTGE+P +C V  C K F+RSDE  RH++THT+G    RI
Sbjct:   15 RPFRCEICSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTHTKGVQRRRI 78

HSP 2 Score: 51.9878 bits (123), Expect = 1.370e-7
Identity = 28/59 (47.46%), Postives = 36/59 (61.02%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHT 891
            ++ F C  E C R F+R +   RH R H+G KP+ C  + C K F+RSD LK H RTHT
Sbjct:   14 QRPFRC--EICSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTHT 70
[Close]
BLAST of early growth response-2 vs. Ensembl Nematostella
Match: EDO49112 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGT8])

HSP 1 Score: 113.235 bits (282), Expect = 2.474e-30
Identity = 49/86 (56.98%), Postives = 65/86 (75.58%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            ++ + C  E+C R+F+RSDEL RH+R H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C ++FARSDE+ RH+K H R
Sbjct:    1 ERPYACPVETCPRRFSRSDELTRHMRTHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACETCGRRFARSDERRRHMKIHLR 86

HSP 2 Score: 53.9138 bits (128), Expect = 2.307e-9
Identity = 27/59 (45.76%), Postives = 36/59 (61.02%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGE 897
            +K F C    C R F+RSD L  H+R H+G KP+ CE C ++FARSD  + H + H  E
Sbjct:   31 QKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACETCGRRFARSDERRRHMKIHLRE 87
[Close]
BLAST of early growth response-2 vs. Ensembl Nematostella
Match: EDO42941 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S019])

HSP 1 Score: 98.2117 bits (243), Expect = 1.428e-24
Identity = 49/110 (44.55%), Postives = 67/110 (60.91%), Query Frame = 1 
Query:  661 KTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCE--FCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            + I+ + P      G  A  +KQ +C+   C + + ++  L  HLR HSG +P+ C   FC K+F RSD L+ HRRTHTGE+ F C  C KKF RSD  S+HVKTH+ G+
Sbjct:    8 RRIACTCPNCRDGEGRTANGRKQHVCHVPGCGKVYGKTSHLRAHLRWHSGERPFVCNWLFCGKRFTRSDELQRHRRTHTGEKRFTCPECNKKFMRSDHLSKHVKTHSNGK 117
[Close]
BLAST of early growth response-2 vs. Ensembl Nematostella
Match: EDO42885 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S016])

HSP 1 Score: 98.5969 bits (244), Expect = 2.071e-22
Identity = 45/95 (47.37%), Postives = 62/95 (65.26%), Query Frame = 1 
Query:  694 SSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCE--FCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTH 972
            S+SG+  + K Q IC+   C + + ++  L  HLR H+G +P+ C   FC K+F RSD L+ H RTHTGE+ F C +C K+F RSD  S+HVKTH
Sbjct:  258 SASGAPFRKKSQHICHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPICSKRFMRSDHLSKHVKTH 352

HSP 2 Score: 71.2478 bits (173), Expect = 1.857e-13
Identity = 30/61 (49.18%), Postives = 40/61 (65.57%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERP 903
            ++ F+CN+  C ++F RSDEL RHLR H+G K + C  C K+F RSDHL  H +TH    P
Sbjct:  297 ERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPICSKRFMRSDHLSKHVKTHNNITP 357

HSP 3 Score: 60.077 bits (144), Expect = 8.526e-10
Identity = 27/49 (55.10%), Postives = 33/49 (67.35%), Query Frame = 1 
Query:  835 CFKKFARSDHLKTHRRTHTGERPFECE--VCQKKFARSDEKSRHVKTHT 975
            C K + ++ HLK H R HTGERPF C    C K+F RSDE  RH++THT
Sbjct:  277 CGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHT 325
[Close]
BLAST of early growth response-2 vs. Ensembl Nematostella
Match: EDO48749 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIN4])

HSP 1 Score: 85.5001 bits (210), Expect = 2.119e-20
Identity = 39/89 (43.82%), Postives = 61/89 (68.54%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEF--CFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            +++ C+YE C + + +S  L  H+R H+G KP+ C +  C  +F+RSD L  H+R+H+G +PF C+VC K+F+RSD  ++H KTH R R
Sbjct:    1 REYKCHYEGCNKIYTKSSHLKAHIRRHTGEKPFICTWKGCNWRFSRSDELARHKRSHSGVKPFVCDVCDKRFSRSDHLAKHRKTHYRVR 89
[Close]
BLAST of early growth response-2 vs. Ensembl Nematostella
Match: EDO32290 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVG8])

HSP 1 Score: 84.7297 bits (208), Expect = 2.955e-20
Identity = 40/88 (45.45%), Postives = 55/88 (62.50%), Query Frame = 1 
Query:  718 PKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEF--CFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            P K+  C Y  C + + +S  L  H R H+G +P+ C +  C K+FARSD L  H RTHTGE+ + C++C K+F RSD  S+H KTH 
Sbjct:    1 PVKKHACTYAGCNKIYGKSSHLKAHTRTHTGERPFMCTWKDCEKRFARSDELARHYRTHTGEKRYVCKICDKRFMRSDHLSKHSKTHA 88
[Close]
BLAST of early growth response-2 vs. Ensembl Medaka
Match: egr1 (early growth response 1 [Source:NCBI gene;Acc:100272163])

HSP 1 Score: 127.487 bits (319), Expect = 4.462e-31
Identity = 50/86 (58.14%), Postives = 66/86 (76.74%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            ++ + C  E+C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE+C +KFARSDE+ RH K H R
Sbjct:  310 ERPYACPVETCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHLR 395
[Close]
BLAST of early growth response-2 vs. Ensembl Medaka
Match: ENSORLT00000034291.1 (early growth response protein 2b [Source:NCBI gene;Acc:101164744])

HSP 1 Score: 124.02 bits (310), Expect = 1.577e-30
Identity = 51/86 (59.30%), Postives = 67/86 (77.91%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            ++ + C  ESC R+F+RSDEL+RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+ C +KFARSDE+ RH+K H R
Sbjct:  301 QRPYPCPAESCDRRFSRSDELSRHLRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFSCQQCGRKFARSDERRRHMKIHLR 386

HSP 2 Score: 66.6254 bits (161), Expect = 2.259e-11
Identity = 32/76 (42.11%), Postives = 45/76 (59.21%), Query Frame = 1 
Query:  754 RRKFNRSDELNRHLRVHSGIKPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            R+  NR  +   H R      PY C  E C ++F+RSD L  H R HTG +PF+C +C + F+RSD  + H++THT
Sbjct:  288 RKYPNRPSKTPVHQR------PYPCPAESCDRRFSRSDELSRHLRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHT 357
[Close]
BLAST of early growth response-2 vs. Ensembl Medaka
Match: ENSORLT00000000940.2 (early growth response protein 1 [Source:NCBI gene;Acc:101160576])

HSP 1 Score: 123.25 bits (308), Expect = 5.536e-30
Identity = 50/88 (56.82%), Postives = 64/88 (72.73%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGR 984
            ++  +C  + C R+F+RSDEL RH+RVH+G KP+ C  C + F+RSDHL TH RTHTGE+PF C  C +KFARSDE+ RH K H R R
Sbjct:  280 ERPHVCPADGCERRFSRSDELTRHVRVHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFPCSECGRKFARSDERKRHAKIHQRQR 367
[Close]
BLAST of early growth response-2 vs. Ensembl Medaka
Match: egr3 (early growth response 3 [Source:NCBI gene;Acc:100272164])

HSP 1 Score: 121.324 bits (303), Expect = 1.634e-29
Identity = 50/81 (61.73%), Postives = 62/81 (76.54%), Query Frame = 1 
Query:  736 CNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            C  E+C R+F+RSDEL RHLR+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF CE C +KFARSDE+ RH K H +
Sbjct:  298 CPAENCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCEFCGRKFARSDERKRHAKVHLK 378

HSP 2 Score: 64.6994 bits (156), Expect = 8.858e-11
Identity = 26/56 (46.43%), Postives = 39/56 (69.64%), Query Frame = 1 
Query:  814 KPYTC--EFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHT 975
            +P+ C  E C ++F+RSD L  H R HTG +PF+C +C + F+RSD  + H++THT
Sbjct:  294 RPHACPAENCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHT 349

HSP 3 Score: 64.3142 bits (155), Expect = 1.105e-10
Identity = 29/59 (49.15%), Postives = 38/59 (64.41%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGER 900
            K F C    C R F+RSD L  H+R H+G KP++CEFC +KFARSD  K H + H  ++
Sbjct:  324 KPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFSCEFCGRKFARSDERKRHAKVHLKQK 380
[Close]
BLAST of early growth response-2 vs. Ensembl Medaka
Match: egr2b (early growth response 2 [Source:NCBI gene;Acc:101170128])

HSP 1 Score: 120.168 bits (300), Expect = 7.213e-29
Identity = 49/86 (56.98%), Postives = 64/86 (74.42%), Query Frame = 1 
Query:  721 KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTR 978
            ++ + C  E C R+F+RSDEL RH+R+H+G KP+ C  C + F+RSDHL TH RTHTGE+PF C+ C +KFARSDE+ RH K H R
Sbjct:  327 ERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHTKIHLR 412
[Close]
BLAST of early growth response-2 vs. Planmine SMEST
Match: SMESG000004840.1 (SMESG000004840.1)

HSP 1 Score: 648.277 bits (1671), Expect = 0.000e+0
Identity = 332/336 (98.81%), Postives = 332/336 (98.81%), Query Frame = 1 
Query:   94 MSSGESPSDVDSKKMIALVGTDKLDGSELDNVKTGLTPPHKTLEFFEQQYNVENIATPMRFDXXXXXXXXXXXXXXXFTSTQGHFMKFDDDTLTSNLEIEIGEIKESGFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRSSDGSITYQF 1101
            MSS ESPSDVDSKKMIALVGTDKLDGSELDNVKTGLTPPHKTLEFFEQQYNVENIATPMRFDEEENLQTELELQTIEFTSTQGHFMKFD DTLTSNLEIEIGEIKESGFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKD KTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVC KKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRSSDGSITYQF
Sbjct:    1 MSSEESPSDVDSKKMIALVGTDKLDGSELDNVKTGLTPPHKTLEFFEQQYNVENIATPMRFDEEENLQTELELQTIEFTSTQGHFMKFDGDTLTSNLEIEIGEIKESGFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDSKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCHKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEKRDKEHRSSDGSITYQF 336
[Close]
BLAST of early growth response-2 vs. Planmine SMEST
Match: SMESG000005384.1 (SMESG000005384.1)

HSP 1 Score: 119.398 bits (298), Expect = 4.763e-29
Identity = 51/96 (53.12%), Postives = 70/96 (72.92%), Query Frame = 1 
Query:  700 SGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRG 987
            S S+    K + CN ++C + F+RSDEL RH R+HSG KP+ C  C + F+RSDHL TH RTHTGE+P+ C +C K+FARSDE+ RH+K H++G+ 
Sbjct:  233 SRSVKGANKVYQCNEKNCSKTFSRSDELTRHKRIHSGEKPFKCSKCERCFSRSDHLATHIRTHTGEKPYFCSICDKRFARSDERKRHLKIHSKGQN 328
[Close]
BLAST of early growth response-2 vs. Planmine SMEST
Match: SMESG000019723.1 (SMESG000019723.1)

HSP 1 Score: 117.087 bits (292), Expect = 1.011e-27
Identity = 50/110 (45.45%), Postives = 70/110 (63.64%), Query Frame = 1 
Query:  724 KQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRISTAPEFEPGDTQNPETEK 1053
            + F+CN+  C R F R+DEL RH+R+H+G +P+ C  C ++F+RSDH KTH RTHTGE+P+ C  C K F RSDEK+RH K HTR    + +    E    +  N   ++
Sbjct:  138 RHFVCNHPLCERSFQRADELKRHMRIHTGERPFKCSICSRQFSRSDHRKTHIRTHTGEKPYNCLFCSKSFTRSDEKTRHEKIHTRSIQKNVVGALKEVRELNIDNYRVQR 247
[Close]
BLAST of early growth response-2 vs. Planmine SMEST
Match: SMESG000028801.1 (SMESG000028801.1)

HSP 1 Score: 113.235 bits (282), Expect = 1.375e-27
Identity = 92/299 (30.77%), Postives = 134/299 (44.82%), Query Frame = 1 
Query:  157 DKLDGSELDNVKTGLTPPHKTLEFFEQQYNVENIATPMRFDXXXXXXXXXXXXXXXFTSTQGHFMKFDDDTLTSNLEIEIGEIKESGFRHLSIDSSRFQLE---------------TDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKP--KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRIS 1002
            +K   S+ D+++TG TP  K   FF+   NV+N+ TP   ++                        F+ +  + N  I    +K+    H  I +   QL                T  V    S     I LD+      + NT    S  QL   PI ++       S  +R S   P+ +KT+        +    I KP  ++ F C +  C  KF+R DEL RH ++HSG KP +C +C K F RSDH  TH RTHTGE+P+ C++C K+FARSDEK RH + H + +    I+
Sbjct:    5 EKFSESDFDSIETGYTPTGKFGTFFKDTSNVDNLDTPQPLEDNS----------------------FEFEDFSFNYLISENRLKKCVDIHDRISNRIRQLSCTSSISCSSSQSCDTTTSVEYKISRGFGNILLDE-----GQKNTLNTNSAIQL-SSPIEES-------SIYNRRSQRPPTDNKTLRKQAHEEKAHKIIIRKPNIERNFPCEF--CPAKFSRRDELKRHEKIHSGEKPLSCPYCDKCFMRSDHRTTHIRTHTGEKPYSCDICSKRFARSDEKLRHKRIHLKEKSKKNIT 266
[Close]
BLAST of early growth response-2 vs. Planmine SMEST
Match: SMESG000028801.1 (SMESG000028801.1)

HSP 1 Score: 113.235 bits (282), Expect = 2.193e-27
Identity = 92/303 (30.36%), Postives = 136/303 (44.88%), Query Frame = 1 
Query:  145 LVGTDKLDGSELDNVKTGLTPPHKTLEFFEQQYNVENIATPMRFDXXXXXXXXXXXXXXXFTSTQGHFMKFDDDTLTSNLEIEIGEIKESGFRHLSIDSSRFQLE---------------TDPVFMGYSSQLSKICLDDILPIINRDNTTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSCSSSGSIAKP--KKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFKKFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLSRIS 1002
            ++  +K   S+ D+++TG TP  K   FF+   NV+N+ TP   ++                        F+ +  + N  I    +K+    H  I +   QL                T  V    S     I LD+      + NT    S  QL   PI ++       S  +R S   P+ +KT+        +    I KP  ++ F C +  C  KF+R DEL RH ++HSG KP +C +C K F RSDH  TH RTHTGE+P+ C++C K+FARSDEK RH + H + +    I+
Sbjct:   26 MLLFEKFSESDFDSIETGYTPTGKFGTFFKDTSNVDNLDTPQPLEDNS----------------------FEFEDFSFNYLISENRLKKCVDIHDRISNRIRQLSCTSSISCSSSQSCDTTTSVEYKISRGFGNILLDE-----GQKNTLNTNSAIQL-SSPIEES-------SIYNRRSQRPPTDNKTLRKQAHEEKAHKIIIRKPNIERNFPCEF--CPAKFSRRDELKRHEKIHSGEKPLSCPYCDKCFMRSDHRTTHIRTHTGEKPYSCDICSKRFARSDEKLRHKRIHLKEKSKKNIT 291
The following BLAST results are available for this feature:
BLAST of early growth response-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
EGR45.804e-3263.53early growth response 4 [Source:HGNC Symbol;Acc:HG... [more]
EGR42.441e-3163.53early growth response 4 [Source:HGNC Symbol;Acc:HG... [more]
EGR14.917e-3156.82early growth response 1 [Source:HGNC Symbol;Acc:HG... [more]
EGR31.108e-2954.55early growth response 3 [Source:HGNC Symbol;Acc:HG... [more]
EGR31.727e-2954.55early growth response 3 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of early growth response-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egrh-21.230e-2950.00EGR (Early Growth factor Response factor) Homolog ... [more]
egrh-22.223e-2949.49EGR (Early Growth factor Response factor) Homolog ... [more]
egrh-23.599e-2955.42EGR (Early Growth factor Response factor) Homolog ... [more]
egrh-25.385e-2954.12EGR (Early Growth factor Response factor) Homolog ... [more]
egrh-16.060e-2954.44EGR (Early Growth factor Response factor) Homolog ... [more]
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BLAST of early growth response-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sr5.885e-3156.82gene:FBgn0003499 transcript:FBtr0083542[more]
sr6.322e-3156.82gene:FBgn0003499 transcript:FBtr0330050[more]
sr8.253e-3156.82gene:FBgn0003499 transcript:FBtr0301615[more]
sr1.427e-3056.82gene:FBgn0003499 transcript:FBtr0344633[more]
sr1.427e-3056.82gene:FBgn0003499 transcript:FBtr0083543[more]
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BLAST of early growth response-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egr45.734e-3258.24early growth response 4 [Source:ZFIN;Acc:ZDB-GENE-... [more]
egr12.171e-3156.82early growth response 1 [Source:NCBI gene;Acc:3049... [more]
egr12.171e-3156.82early growth response 1 [Source:NCBI gene;Acc:3049... [more]
egr31.969e-2961.73early growth response 3 [Source:ZFIN;Acc:ZDB-GENE-... [more]
egr2a3.128e-2956.98early growth response 2a [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of early growth response-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egr12.096e-3156.82early growth response 1 [Source:NCBI gene;Acc:1000... [more]
egr12.526e-3156.82early growth response 1 [Source:NCBI gene;Acc:1000... [more]
usp315.992e-3059.55ubiquitin specific peptidase 31 [Source:Xenbase;Ac... [more]
tbl1x4.081e-2953.13transducin beta like 1 X-linked [Source:Xenbase;Ac... [more]
serpinb49.901e-2962.03serpin peptidase inhibitor, clade B (ovalbumin), m... [more]
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BLAST of early growth response-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Egr42.562e-3263.53early growth response 4 [Source:MGI Symbol;Acc:MGI... [more]
Egr12.511e-3139.44early growth response 1 [Source:MGI Symbol;Acc:MGI... [more]
Egr12.511e-3139.44early growth response 1 [Source:MGI Symbol;Acc:MGI... [more]
Egr37.460e-3054.55early growth response 3 [Source:MGI Symbol;Acc:MGI... [more]
Egr31.076e-2954.55early growth response 3 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of early growth response-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9WUF2|EGR4_MOUSE1.792e-3163.53Early growth response protein 4 OS=Mus musculus OX... [more]
sp|Q00911|EGR4_RAT2.070e-3163.53Early growth response protein 4 OS=Rattus norvegic... [more]
sp|Q9GL32|EGR4_BOVIN3.099e-3162.79Early growth response protein 4 OS=Bos taurus OX=9... [more]
sp|Q05215|EGR4_HUMAN1.172e-3063.53Early growth response protein 4 OS=Homo sapiens OX... [more]
sp|A4II20|EGR1_XENTR1.338e-3056.82Early growth response protein 1 OS=Xenopus tropica... [more]
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BLAST of early growth response-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZI713.145e-13696.06Early growth response-2 (Fragment) OS=Schmidtea me... [more]
T1E1F41.225e-11358.11Egrl-2 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
A0A5K3FS575.033e-3240.20Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A0R3U9C55.202e-3240.20Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A0R3X7W53.609e-3163.16Uncharacterized protein OS=Hydatigena taeniaeformi... [more]
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BLAST of early growth response-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egr43.024e-3340.12early growth response protein 1-B [Source:NCBI gen... [more]
egr44.218e-3157.14early growth response protein 1-B [Source:NCBI gen... [more]
egr15.283e-3158.14early growth response 1 [Source:NCBI gene;Acc:1030... [more]
EGR28.666e-3053.54early growth response protein 2b-like [Source:NCBI... [more]
egr31.379e-2961.73early growth response 3 [Source:NCBI gene;Acc:1030... [more]
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BLAST of early growth response-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egr49.756e-3256.32early growth response 4 [Source:ZFIN;Acc:ZDB-GENE-... [more]
wt1a4.747e-2455.32WT1 transcription factor a [Source:ZFIN;Acc:ZDB-GE... [more]
sp47.836e-2347.31sp4 transcription factor [Source:ZFIN;Acc:ZDB-GENE... [more]
sp48.851e-2347.31sp4 transcription factor [Source:ZFIN;Acc:ZDB-GENE... [more]
ENSPMAT00000008916.11.078e-2247.31pep scaffold:Pmarinus_7.0:GL476670:39536:47416:-1 ... [more]
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BLAST of early growth response-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
AZF12.434e-1939.00Zinc-finger transcription factor; involved in diau... [more]
ZAP12.469e-1833.33Zinc-regulated transcription factor; binds to zinc... [more]
MSN21.009e-1455.36Stress-responsive transcriptional activator; activ... [more]
FZF11.226e-1435.04Transcription factor involved in sulfite metabolis... [more]
MIG38.003e-1451.56Transcriptional regulator; partially nonfunctional... [more]
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BLAST of early growth response-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO491122.474e-3056.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO429411.428e-2444.55Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428852.071e-2247.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO487492.119e-2043.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO322902.955e-2045.45Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of early growth response-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egr14.462e-3158.14early growth response 1 [Source:NCBI gene;Acc:1002... [more]
ENSORLT00000034291.11.577e-3059.30early growth response protein 2b [Source:NCBI gene... [more]
ENSORLT00000000940.25.536e-3056.82early growth response protein 1 [Source:NCBI gene;... [more]
egr31.634e-2961.73early growth response 3 [Source:NCBI gene;Acc:1002... [more]
egr2b7.213e-2956.98early growth response 2 [Source:NCBI gene;Acc:1011... [more]
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BLAST of early growth response-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000004840.10.000e+098.81SMESG000004840.1[more]
SMESG000005384.14.763e-2953.13SMESG000005384.1[more]
SMESG000019723.11.011e-2745.45SMESG000019723.1[more]
SMESG000028801.11.375e-2730.77SMESG000028801.1[more]
SMESG000028801.12.193e-2730.36SMESG000028801.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30034500
GenBankAFJ24725.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034500 ID=SMED30034500|Name=early growth response-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1636bp
TTGAAATCTAAATATAGCAACAGTTACTATAGTATATGTTATGAATGAAA
TTATCAGTAAAAATCGAAAGATAGTAATTGTTTCACTGCGTCAATGAGTT
CAGGAGAATCGCCGAGTGATGTAGATTCAAAGAAAATGATAGCTCTTGTT
GGAACAGATAAATTAGATGGCAGTGAACTGGACAATGTGAAAACTGGATT
AACGCCTCCACATAAAACGTTAGAATTTTTCGAACAACAATACAATGTTG
AGAATATTGCAACACCGATGCGTTTTGATGAAGAGGAAAATTTACAAACA
GAATTAGAATTGCAAACAATCGAATTTACCTCAACTCAAGGACATTTTAT
GAAATTCGACGATGACACTTTAACTTCAAATCTCGAAATCGAGATTGGAG
AAATTAAAGAATCCGGCTTCAGACATTTATCAATTGACAGTTCTCGTTTT
CAACTGGAAACGGATCCAGTTTTTATGGGATATTCTTCTCAACTGTCAAA
GATCTGCTTAGATGATATTTTACCAATCATTAATCGTGACAATACTACCG
GTGAACCAAGTACAAGTCAACTGAAAGAAGAGCCCATACGGAAGACTAAA
GATATCAAGACTTTCATGTCATGGGAATCTCGGCATTCCTGGGATACTCC
AAGTTCATCAAAAACTATATCATACTCAACTCCTCGAAGTTGCAGCAGTA
GTGGATCCATCGCAAAACCAAAGAAACAATTTATTTGTAATTATGAGTCG
TGTAGGCGAAAATTTAATAGATCAGACGAATTGAATCGACATTTGCGAGT
TCATTCAGGAATCAAACCATACACCTGTGAATTTTGTTTCAAGAAATTTG
CACGCAGTGATCACTTGAAAACTCACAGACGTACCCATACTGGAGAAAGA
CCGTTTGAATGTGAGGTTTGTCAAAAGAAATTCGCTCGGTCTGATGAAAA
ATCACGACACGTTAAAACTCATACTCGGGGAAGAGGACTTTCTCGAATTT
CGACAGCTCCTGAATTCGAACCAGGAGATACTCAAAATCCAGAAACAGAA
AAGAGAGATAAAGAACACCGGTCGTCAGATGGATCCATAACTTATCAGTT
TTGAAGAAAAAACAAAATTTTATATTTCAATTTTTTTATTCAATTTTTTA
TTAATATTTTTATGTTGTGCTCATGAGATCGCGTTTATTTTTCTTGGATT
TGCTCTTCAGCATTTATTCTACATGTTGATAGTCACTTGTTTACATTATT
TACACACTTTGATGTCAAAGTAATCTTGAGATGTTTTATTTGTAAATAAC
TATTTGATTTTTATCCACTTCGATGGCTTTATTATATTTGTTGAATTGTA
ATAACTATTGTAAAATATGCGATTGATATTTATTTCTGTGTCAAACTGTG
AACACTCTTGTACCGCACATTTTGCTTGAAATTTATTTATTGACACTGAT
TACGTTAATAAAAAAATCGGATGAAATCTCGTTTTCTTTTTCGAAAATGA
ATTTCAGAATGTGTACAATAGAAGTTTTTTTTCAGAATTACTACTGCTAC
CAAAAGTTCAGTTCTCAAAAGTTTAAAAAATAAATTTTGATTTAAATGTT
GGTTAAAACTACAGAAAAAAGAGAATTTTTTCAAAA
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protein sequence of SMED30034500-orf-1

>SMED30034500-orf-1 ID=SMED30034500-orf-1|Name=SMED30034500-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=337bp
MSSGESPSDVDSKKMIALVGTDKLDGSELDNVKTGLTPPHKTLEFFEQQY
NVENIATPMRFDEEENLQTELELQTIEFTSTQGHFMKFDDDTLTSNLEIE
IGEIKESGFRHLSIDSSRFQLETDPVFMGYSSQLSKICLDDILPIINRDN
TTGEPSTSQLKEEPIRKTKDIKTFMSWESRHSWDTPSSSKTISYSTPRSC
SSSGSIAKPKKQFICNYESCRRKFNRSDELNRHLRVHSGIKPYTCEFCFK
KFARSDHLKTHRRTHTGERPFECEVCQKKFARSDEKSRHVKTHTRGRGLS
RISTAPEFEPGDTQNPETEKRDKEHRSSDGSITYQF*
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Aliases
The feature 'early growth response-2' has the following synonyms
Synonym
EGR-2
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0000103central nervous system
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036236Znf_C2H2_sf
IPR015880Znf_C2H2-like
IPR013087Znf_C2H2_type
IPR007087Znf_C2H2
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0046872metal ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR013087Zinc finger C2H2-typeSMARTSM00355c2h2final6coord: 243..265
e-value: 0.019
score: 24.1
coord: 271..293
e-value: 0.024
score: 23.8
coord: 213..237
e-value: 0.0032
score: 26.7
IPR013087Zinc finger C2H2-typePFAMPF00096zf-C2H2coord: 213..237
e-value: 0.0017
score: 18.7
coord: 243..265
e-value: 7.0E-4
score: 19.9
coord: 271..293
e-value: 0.0087
score: 16.5
IPR013087Zinc finger C2H2-typePROSITEPS00028ZINC_FINGER_C2H2_1coord: 273..293
IPR013087Zinc finger C2H2-typePROSITEPS00028ZINC_FINGER_C2H2_1coord: 215..237
IPR013087Zinc finger C2H2-typePROSITEPS00028ZINC_FINGER_C2H2_1coord: 245..265
IPR013087Zinc finger C2H2-typePROSITEPS50157ZINC_FINGER_C2H2_2coord: 271..298
score: 11.468
IPR013087Zinc finger C2H2-typePROSITEPS50157ZINC_FINGER_C2H2_2coord: 213..242
score: 14.461
IPR013087Zinc finger C2H2-typePROSITEPS50157ZINC_FINGER_C2H2_2coord: 243..270
score: 16.332
NoneNo IPR availableGENE3DG3DSA:3.30.160.60coord: 265..295
e-value: 3.3E-10
score: 41.7
NoneNo IPR availableGENE3DG3DSA:3.30.160.60coord: 237..264
e-value: 2.9E-13
score: 51.6
NoneNo IPR availableGENE3DG3DSA:3.30.160.60coord: 204..236
e-value: 3.6E-10
score: 41.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 284..336
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 150..173
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 313..329
NoneNo IPR availablePANTHERPTHR23235TRANSCRIPTION FACTOR SP3coord: 188..296
IPR036236Zinc finger C2H2 superfamilySUPERFAMILYSSF57667beta-beta-alpha zinc fingerscoord: 207..252
IPR036236Zinc finger C2H2 superfamilySUPERFAMILYSSF57667beta-beta-alpha zinc fingerscoord: 237..289