FGFR1

Overview
NameFGFR1 (AFD29628.1)
Smed IDSMED30034490
Length (bp)2276
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of FGFR1 (SMED30034490) t-SNE clustered cells

Violin plots show distribution of expression levels for FGFR1 (SMED30034490) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FGFR1 (SMED30034490) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FGFR1 (SMED30034490) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30034490

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 26

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pigment cellSMED30034490SMESG000036598.1 SMESG000036590.1 SmedASXL_015337SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
X1 cellSMED30034490SMESG000036598.1 SMESG000036590.1 SmedASXL_015337SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30034490SMESG000036598.1 SMESG000036590.1 SmedASXL_015337SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30034490SMESG000036590.1 SmedASXL_015338SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
pharynxSMED30034490SMESG000036598.1 SMESG000036590.1 dd_Smed_v4_6020_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30034490SMESG000036598.1 SMESG000036590.1 dd_Smed_v4_6020_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30034490SMESG000036598.1 SMESG000036590.1 dd_Smed_v4_6020_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30034490SMESG000036598.1 SMESG000036590.1 dd_Smed_v4_6020_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30034490SMESG000036598.1 SMESG000036590.1 JQ425160smed_ncbi_20200123PMID:25017721
van Wolfswinkel et al., 2014
FACS sorted cell population asexual adult fluorescence in situ hybridization evidence
zeta neoblastSMED30034490SMESG000036598.1 SMESG000036590.1 JQ425160smed_ncbi_20200123PMID:25017721
van Wolfswinkel et al., 2014
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30034490SMESG000036598.1 SMESG000036590.1 SMED30034490smed_20140614PMID:26457503
Tu et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30034490SMESG000036598.1 SMESG000036590.1 JQ425160.1smed_ncbi_20200123PMID:27523733
Lei et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30034490SMESG000036598.1 SMESG000036590.1 JQ425160.1smed_ncbi_20200123PMID:27523733
Lei et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
neoblastSMED30034490SMESG000036598.1 SMED_38140_V2_2GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_38140_V2_2GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036590.1 SMED_38141_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036590.1 SMED_38141_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_38140_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_38140_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036590.1 SMED_38141_V2_2GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036590.1 SMED_38141_V2_2GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_23395_V2_2GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_23395_V2_2GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_23395_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMED_23395_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30034490SMESG000036598.1 SMESG000036590.1 SMED30034490smed_20140614PMID:22385657
Wagner et al., 2012
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of FGFR1 vs. Ensembl Human
Match: FGFR2 (fibroblast growth factor receptor 2 [Source:HGNC Symbol;Acc:HGNC:3689])

HSP 1 Score: 199.134 bits (505), Expect = 2.144e-54
Identity = 108/294 (36.73%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV---------DSRDVAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INH-PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + K E PR+ + + G  LGEG FG V +            ++  VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P        IN  P +++    L + T Q+ +GM YL+S+  +HRDLA RN+L+ EN  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  240 LPEDPKWEFPRDKLTL-GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 532          
BLAST of FGFR1 vs. Ensembl Human
Match: FGFR1 (fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688])

HSP 1 Score: 200.29 bits (508), Expect = 7.334e-54
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  376 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668          
BLAST of FGFR1 vs. Ensembl Human
Match: FGFR1 (fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688])

HSP 1 Score: 200.29 bits (508), Expect = 7.477e-54
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  376 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668          
BLAST of FGFR1 vs. Ensembl Human
Match: FGFR1 (fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688])

HSP 1 Score: 199.904 bits (507), Expect = 7.809e-54
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  374 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 666          
BLAST of FGFR1 vs. Ensembl Human
Match: FGFR2 (fibroblast growth factor receptor 2 [Source:HGNC Symbol;Acc:HGNC:3689])

HSP 1 Score: 199.134 bits (505), Expect = 9.992e-54
Identity = 108/294 (36.73%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV---------DSRDVAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INH-PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + K E PR+ + + G  LGEG FG V +            ++  VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P        IN  P +++    L + T Q+ +GM YL+S+  +HRDLA RN+L+ EN  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  380 LPEDPKWEFPRDKLTL-GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 672          
BLAST of FGFR1 vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1)

HSP 1 Score: 172.555 bits (436), Expect = 2.396e-46
Identity = 94/270 (34.81%), Postives = 153/270 (56.67%), Query Frame = 3
Query: 1377 RNHVKVSGVKLGEGNFGTVFLGSVDSRD-----VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            R    V G  +GEG FG VF G +   +     VA+K       ++ ++    E++MMQ +G+H +++ + G C DE     IME    G LK+YLQ+     +     I+  +  ++T QI  GM +L S  I+HRDLA RNIL+     +KI+DFG++R  +  Y  MS+   P RW++PE   +N ++ KSDVW++G++LWEI TLG  PY +++  ++ + +  G+  ++P      +Y LMK CW    + RP+F  I++++E +
Sbjct:  185 RGQDIVVGAVIGEGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSD-SAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPGV--YIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQI 451          
BLAST of FGFR1 vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6])

HSP 1 Score: 172.94 bits (437), Expect = 5.271e-46
Identity = 95/278 (34.17%), Postives = 151/278 (54.32%), Query Frame = 3
Query: 1335 DYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQ---DMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            D  S+  ++ L I  N + V G  +G G FG V LG+  +R VA+K+    G    D L DE + M  +  H +++ L+G+  D+ +++ I E  + G+L + L+S           +   QL  + + I +GM YL SK IVHRDLA RN+LL ++   K++DFGL +   +  H  +    P +W APE    ++FT KSDVWS+GI+LWEIF+ G +PY  +   +V   I  G   + PE  P  ++ +M + W      RP+F  ++ +L ++
Sbjct:  266 DRTSVFRHAGLVISSNDIDV-GDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLS-HPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGR------HALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 535          
BLAST of FGFR1 vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6])

HSP 1 Score: 172.94 bits (437), Expect = 5.271e-46
Identity = 95/278 (34.17%), Postives = 151/278 (54.32%), Query Frame = 3
Query: 1335 DYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQ---DMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            D  S+  ++ L I  N + V G  +G G FG V LG+  +R VA+K+    G    D L DE + M  +  H +++ L+G+  D+ +++ I E  + G+L + L+S           +   QL  + + I +GM YL SK IVHRDLA RN+LL ++   K++DFGL +   +  H  +    P +W APE    ++FT KSDVWS+GI+LWEIF+ G +PY  +   +V   I  G   + PE  P  ++ +M + W      RP+F  ++ +L ++
Sbjct:  266 DRTSVFRHAGLVISSNDIDV-GDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLS-HPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGR------HALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 535          
BLAST of FGFR1 vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6])

HSP 1 Score: 173.326 bits (438), Expect = 1.333e-45
Identity = 95/278 (34.17%), Postives = 151/278 (54.32%), Query Frame = 3
Query: 1335 DYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQ---DMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            D  S+  ++ L I  N + V G  +G G FG V LG+  +R VA+K+    G    D L DE + M  +  H +++ L+G+  D+ +++ I E  + G+L + L+S           +   QL  + + I +GM YL SK IVHRDLA RN+LL ++   K++DFGL +   +  H  +    P +W APE    ++FT KSDVWS+GI+LWEIF+ G +PY  +   +V   I  G   + PE  P  ++ +M + W      RP+F  ++ +L ++
Sbjct:  351 DRTSVFRHAGLVISSNDIDV-GDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLS-HPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGR------HALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 620          
BLAST of FGFR1 vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6])

HSP 1 Score: 173.326 bits (438), Expect = 1.333e-45
Identity = 95/278 (34.17%), Postives = 151/278 (54.32%), Query Frame = 3
Query: 1335 DYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQ---DMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            D  S+  ++ L I  N + V G  +G G FG V LG+  +R VA+K+    G    D L DE + M  +  H +++ L+G+  D+ +++ I E  + G+L + L+S           +   QL  + + I +GM YL SK IVHRDLA RN+LL ++   K++DFGL +   +  H  +    P +W APE    ++FT KSDVWS+GI+LWEIF+ G +PY  +   +V   I  G   + PE  P  ++ +M + W      RP+F  ++ +L ++
Sbjct:  351 DRTSVFRHAGLVISSNDIDV-GDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLS-HPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGR------HALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 620          
BLAST of FGFR1 vs. Ensembl Fly
Match: htl (gene:FBgn0010389 transcript:FBtr0083550)

HSP 1 Score: 194.897 bits (494), Expect = 2.127e-52
Identity = 109/290 (37.59%), Postives = 165/290 (56.90%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQD----MLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL------------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFS-LSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
              ++S  E+PR+H+ V G  LGEG FG V +  V++  VA+K+  E   D     L  E+ +M+ IGRH +++ L+G C   G L+ I+E A  G+LK++L    P              + P   I    L  +  QI +GM+YL+S+  +HRDLA RN+L++++  +KIADFGL R +   +YY   +    P +WMAPE   E  + +KSDVWSYGI+LWEI T G  PY + +S  E+   + +G   +KP      +Y LM++CW F+ D RP F +IV  ++ +
Sbjct:  403 FPLDSNWELPRSHL-VLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691          
BLAST of FGFR1 vs. Ensembl Fly
Match: htl (gene:FBgn0010389 transcript:FBtr0083549)

HSP 1 Score: 194.897 bits (494), Expect = 2.127e-52
Identity = 109/290 (37.59%), Postives = 165/290 (56.90%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQD----MLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL------------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFS-LSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
              ++S  E+PR+H+ V G  LGEG FG V +  V++  VA+K+  E   D     L  E+ +M+ IGRH +++ L+G C   G L+ I+E A  G+LK++L    P              + P   I    L  +  QI +GM+YL+S+  +HRDLA RN+L++++  +KIADFGL R +   +YY   +    P +WMAPE   E  + +KSDVWSYGI+LWEI T G  PY + +S  E+   + +G   +KP      +Y LM++CW F+ D RP F +IV  ++ +
Sbjct:  403 FPLDSNWELPRSHL-VLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691          
BLAST of FGFR1 vs. Ensembl Fly
Match: htl (gene:FBgn0010389 transcript:FBtr0083548)

HSP 1 Score: 194.897 bits (494), Expect = 2.127e-52
Identity = 109/290 (37.59%), Postives = 165/290 (56.90%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQD----MLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL------------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFS-LSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
              ++S  E+PR+H+ V G  LGEG FG V +  V++  VA+K+  E   D     L  E+ +M+ IGRH +++ L+G C   G L+ I+E A  G+LK++L    P              + P   I    L  +  QI +GM+YL+S+  +HRDLA RN+L++++  +KIADFGL R +   +YY   +    P +WMAPE   E  + +KSDVWSYGI+LWEI T G  PY + +S  E+   + +G   +KP      +Y LM++CW F+ D RP F +IV  ++ +
Sbjct:  403 FPLDSNWELPRSHL-VLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691          
BLAST of FGFR1 vs. Ensembl Fly
Match: btl (gene:FBgn0285896 transcript:FBtr0100676)

HSP 1 Score: 189.119 bits (479), Expect = 1.532e-49
Identity = 107/312 (34.29%), Postives = 165/312 (52.88%), Query Frame = 3
Query: 1317 DVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP------------LINHP---CQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFS-LSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            D  Q  +     ++S  EIPR  + +  + LGEG FG V +   +            VA+K+  E+  D     L  E+ +M+ IG+H +++ L+G C   G LW I+E A  G+LK++L+   P            L + P    Q +   +L  +  QI +GM YL+S+  +HRDLA RN+L+++   +KIADFGL R +    YY   +    P +WMAPE   E ++ ++SDVWSYG++LWEI T G  PY   LS  E+   +  G   +KP      +Y +M++CW F+   RPTFA++V   + +
Sbjct:  689 DPAQGFNEYEFPLDSNWEIPRQQLSLGSI-LGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGI 999          
BLAST of FGFR1 vs. Ensembl Fly
Match: btl (gene:FBgn0285896 transcript:FBtr0075778)

HSP 1 Score: 189.119 bits (479), Expect = 1.532e-49
Identity = 107/312 (34.29%), Postives = 165/312 (52.88%), Query Frame = 3
Query: 1317 DVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP------------LINHP---CQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFS-LSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            D  Q  +     ++S  EIPR  + +  + LGEG FG V +   +            VA+K+  E+  D     L  E+ +M+ IG+H +++ L+G C   G LW I+E A  G+LK++L+   P            L + P    Q +   +L  +  QI +GM YL+S+  +HRDLA RN+L+++   +KIADFGL R +    YY   +    P +WMAPE   E ++ ++SDVWSYG++LWEI T G  PY   LS  E+   +  G   +KP      +Y +M++CW F+   RPTFA++V   + +
Sbjct:  689 DPAQGFNEYEFPLDSNWEIPRQQLSLGSI-LGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGI 999          
BLAST of FGFR1 vs. Ensembl Zebrafish
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:58129])

HSP 1 Score: 193.741 bits (491), Expect = 1.161e-54
Identity = 108/303 (35.64%), Postives = 162/303 (53.47%), Query Frame = 3
Query: 1320 VIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            ++ N   + L  + K E  R  + + G  LGEG FG V +      D         VA+K+  + G D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P + +    L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V   + V
Sbjct:   20 MLPNVSELELPSDPKWEFTRTKLTL-GKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRV 321          
BLAST of FGFR1 vs. Ensembl Zebrafish
Match: fgfr1b (fibroblast growth factor receptor 1b [Source:ZFIN;Acc:ZDB-GENE-060503-14])

HSP 1 Score: 197.593 bits (501), Expect = 5.250e-53
Identity = 106/277 (38.27%), Postives = 155/277 (55.96%), Query Frame = 3
Query: 1392 VSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINH--------PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            V G  LGEG FG V +G     D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P            P + +++  L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP    + +Y +MK CW      RPTF  +V  L+
Sbjct:  424 VLGKPLGEGCFGQVVMGEAIGLDKDKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEFASKGNLREYLRARRPHGMEYCYNPDPLPIESMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLREGHRMDKPSACTQELYLMMKDCWHAVPTQRPTFKQLVEDLD 700          
BLAST of FGFR1 vs. Ensembl Zebrafish
Match: fgfr1b (fibroblast growth factor receptor 1b [Source:ZFIN;Acc:ZDB-GENE-060503-14])

HSP 1 Score: 197.208 bits (500), Expect = 5.366e-53
Identity = 106/277 (38.27%), Postives = 155/277 (55.96%), Query Frame = 3
Query: 1392 VSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINH--------PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            V G  LGEG FG V +G     D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P            P + +++  L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP    + +Y +MK CW      RPTF  +V  L+
Sbjct:  398 VLGKPLGEGCFGQVVMGEAIGLDKDKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEFASKGNLREYLRARRPHGMEYCYNPDPLPIESMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLREGHRMDKPSACTQELYLMMKDCWHAVPTQRPTFKQLVEDLD 674          
BLAST of FGFR1 vs. Ensembl Zebrafish
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:58129])

HSP 1 Score: 194.512 bits (493), Expect = 7.398e-52
Identity = 115/333 (34.53%), Postives = 176/333 (52.85%), Query Frame = 3
Query: 1251 LRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRN------HVKVS-GVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L+R   L++++ +     LV    + + D   L   S+LE+P +        K++ G  LGEG FG V +      D         VA+K+  + G D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P + +    L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V   + V
Sbjct:  407 LKRQVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRV 739          
BLAST of FGFR1 vs. Ensembl Zebrafish
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:58129])

HSP 1 Score: 194.897 bits (494), Expect = 7.849e-52
Identity = 115/333 (34.53%), Postives = 176/333 (52.85%), Query Frame = 3
Query: 1251 LRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRN------HVKVS-GVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L+R   L++++ +     LV    + + D   L   S+LE+P +        K++ G  LGEG FG V +      D         VA+K+  + G D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P + +    L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V   + V
Sbjct:  426 LKRQVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRV 758          
BLAST of FGFR1 vs. Ensembl Xenopus
Match: fgfr4 (fibroblast growth factor receptor 4 [Source:NCBI gene;Acc:549077])

HSP 1 Score: 200.675 bits (509), Expect = 4.410e-54
Identity = 110/296 (37.16%), Postives = 167/296 (56.42%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLG---SVDSR------DVAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L +++K E PR+ + V G  LGEG FG V       +D         VA+K+  + G D     L  E+ +M+ IG+H++++ L+G+C  EG L+ I+E AS G+L+ +L++  P        +   P + ++   L +   Q+ +GM YL SK  +HRDLA RN+L+AE+  +KIADFGL R V  I+YY   S    P +WMAPE   +  +T +SD+WS+G++ WEIFTLG  PY  +   E+   +  G   DKP      +Y LM++CW      RPTF  +V QL+ +
Sbjct:  381 VELPLDAKWEFPRDRL-VLGKPLGEGCFGQVVRAEGYGIDKERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPSQRPTFKQLVEQLDRI 675          
BLAST of FGFR1 vs. Ensembl Xenopus
Match: fgfr4 (fibroblast growth factor receptor 4 [Source:NCBI gene;Acc:549077])

HSP 1 Score: 201.06 bits (510), Expect = 8.594e-54
Identity = 110/296 (37.16%), Postives = 167/296 (56.42%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLG---SVDSR------DVAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L +++K E PR+ + V G  LGEG FG V       +D         VA+K+  + G D     L  E+ +M+ IG+H++++ L+G+C  EG L+ I+E AS G+L+ +L++  P        +   P + ++   L +   Q+ +GM YL SK  +HRDLA RN+L+AE+  +KIADFGL R V  I+YY   S    P +WMAPE   +  +T +SD+WS+G++ WEIFTLG  PY  +   E+   +  G   DKP      +Y LM++CW      RPTF  +V QL+ +
Sbjct:  479 VELPLDAKWEFPRDRL-VLGKPLGEGCFGQVVRAEGYGIDKERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPSQRPTFKQLVEQLDRI 773          
BLAST of FGFR1 vs. Ensembl Xenopus
Match: fgfr4 (fibroblast growth factor receptor 4 [Source:NCBI gene;Acc:549077])

HSP 1 Score: 200.675 bits (509), Expect = 8.613e-54
Identity = 110/296 (37.16%), Postives = 167/296 (56.42%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLG---SVDSR------DVAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L +++K E PR+ + V G  LGEG FG V       +D         VA+K+  + G D     L  E+ +M+ IG+H++++ L+G+C  EG L+ I+E AS G+L+ +L++  P        +   P + ++   L +   Q+ +GM YL SK  +HRDLA RN+L+AE+  +KIADFGL R V  I+YY   S    P +WMAPE   +  +T +SD+WS+G++ WEIFTLG  PY  +   E+   +  G   DKP      +Y LM++CW      RPTF  +V QL+ +
Sbjct:  448 VELPLDAKWEFPRDRL-VLGKPLGEGCFGQVVRAEGYGIDKERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPSQRPTFKQLVEQLDRI 742          
BLAST of FGFR1 vs. Ensembl Xenopus
Match: fgfr4 (fibroblast growth factor receptor 4 [Source:NCBI gene;Acc:549077])

HSP 1 Score: 201.06 bits (510), Expect = 9.678e-54
Identity = 110/296 (37.16%), Postives = 166/296 (56.08%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L +++K E PR+ + V G  LGEG FG V        D         VA+K+  + G D     L  E+ +M+ IG+H++++ L+G+C  EG L+ I+E AS G+L+ +L++  P        +   P + ++   L +   Q+ +GM YL SK  +HRDLA RN+L+AE+  +KIADFGL R V  I+YY   S    P +WMAPE   +  +T +SD+WS+G++ WEIFTLG  PY  +   E+   +  G   DKP      +Y LM++CW      RPTF  +V QL+ +
Sbjct:  473 VELPLDAKWEFPRDRL-VLGKPLGEGCFGQVVRAEGYGIDKERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPSQRPTFKQLVEQLDRI 767          
BLAST of FGFR1 vs. Ensembl Xenopus
Match: fgfr4 (fibroblast growth factor receptor 4 [Source:NCBI gene;Acc:549077])

HSP 1 Score: 200.675 bits (509), Expect = 1.063e-53
Identity = 110/296 (37.16%), Postives = 166/296 (56.08%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L +++K E PR+ + V G  LGEG FG V        D         VA+K+  + G D     L  E+ +M+ IG+H++++ L+G+C  EG L+ I+E AS G+L+ +L++  P        +   P + ++   L +   Q+ +GM YL SK  +HRDLA RN+L+AE+  +KIADFGL R V  I+YY   S    P +WMAPE   +  +T +SD+WS+G++ WEIFTLG  PY  +   E+   +  G   DKP      +Y LM++CW      RPTF  +V QL+ +
Sbjct:  447 VELPLDAKWEFPRDRL-VLGKPLGEGCFGQVVRAEGYGIDKERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPSQRPTFKQLVEQLDRI 741          
BLAST of FGFR1 vs. Ensembl Mouse
Match: Fgfr2 (fibroblast growth factor receptor 2 [Source:MGI Symbol;Acc:MGI:95523])

HSP 1 Score: 199.519 bits (506), Expect = 1.589e-54
Identity = 108/294 (36.73%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV---------DSRDVAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INH-PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + K E PR+ + + G  LGEG FG V +            ++  VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P        IN  P +++    L + T Q+ +GM YL+S+  +HRDLA RN+L+ EN  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  256 LPEDPKWEFPRDKLTL-GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 548          
BLAST of FGFR1 vs. Ensembl Mouse
Match: Fgfr2 (fibroblast growth factor receptor 2 [Source:MGI Symbol;Acc:MGI:95523])

HSP 1 Score: 199.134 bits (505), Expect = 1.776e-54
Identity = 108/294 (36.73%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV---------DSRDVAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INH-PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + K E PR+ + + G  LGEG FG V +            ++  VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P        IN  P +++    L + T Q+ +GM YL+S+  +HRDLA RN+L+ EN  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  255 LPEDPKWEFPRDKLTL-GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 547          
BLAST of FGFR1 vs. Ensembl Mouse
Match: Fgfr1 (fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522])

HSP 1 Score: 200.29 bits (508), Expect = 4.891e-54
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  376 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668          
BLAST of FGFR1 vs. Ensembl Mouse
Match: Fgfr1 (fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522])

HSP 1 Score: 200.29 bits (508), Expect = 4.891e-54
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  376 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668          
BLAST of FGFR1 vs. Ensembl Mouse
Match: Fgfr1 (fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522])

HSP 1 Score: 200.29 bits (508), Expect = 4.891e-54
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  376 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668          
BLAST of FGFR1 vs. UniProt/SwissProt
Match: sp|Q8MY86|FGFR1_DUGJA (Fibroblast growth factor receptor 1 OS=Dugesia japonica OX=6161 GN=FGFR1 PE=2 SV=1)

HSP 1 Score: 228.024 bits (580), Expect = 2.245e-62
Identity = 121/279 (43.37%), Postives = 177/279 (63.44%), Query Frame = 3
Query: 1356 NSKLEIPRNHVKVSGVKLGEGNFGTVFLG---SVDSRDVAIKIPTEQGQDMLFD--------EVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEIN---LNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQL 2150
            ++K E PR  +K++  KLGEG FG V+ G    + +R   IK+  +  +D   D        E+ +M+ IGRH +V++L+GLC  +G L  I+ELA  G+L++++++ N   +   + I     + L TY+LQI +GM YL+S+S+VHRDL+ RNIL+ E+ ++KIADFGLTRIV  YY   ++   P +WMAPE  +E ++T KSDVWSYGI+LWEIFTLG  PY ++   +V D I  G  N KPE++   +Y LM+ CW    + RP F +IV  L
Sbjct:  540 DAKWEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVHDFVKEMEIMKHIGRHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKIIGNFTSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIVDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVDLIRKGFQNPKPELANFEIYRLMQHCWSLSSENRPNFFEIVEIL 818          

HSP 2 Score: 63.5438 bits (153), Expect = 5.432e-9
Identity = 91/364 (25.00%), Postives = 154/364 (42.31%), Query Frame = 3
Query:  171 SKLEYQTAR---LSCHINVIKRCRKGSVRWAWFKDN----IQIKNGTRKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIK-NGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEK-LRFTGNSTICAGQKFIFNCSTE----------------------KYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISE----RMMHLTVIPC 1157
            +KL ++T+    L+C   V ++C+K  ++  W+KDN     +I+ G + K R +  ++       ++D+G Y C V N   N S +    ++V   E   +  N + L+ S +     Y  P+M  E Y +    E+     +QC+FFS   +N+ +V WY      N  +     +L+   S++ I +   +C Q    +I  +  C  S  +    S      TC I    N   +      +   VD  +   L F  +ST+C G  F   C T                         S++ LF+   N+NE    +S    E+++K  D   +G YLC   S++E     +MHL+VI C
Sbjct:   36 NKLNWRTSEEMVLTCKAVVNEKCKKSKLQMRWYKDNELLGKKIERGLKMKYRYRKKLK-------LNDSGNYTCFVFNKNGNSSVF--FLINVTEKENFHVNENKI-LDGSEISNNTLYLHPEMGMENYHVIPNDEIV----MQCRFFSPISINL-TVSWYQHSCDSNYHN----AQLLVKDSKFNISSNKESC-QSYLSHIPLDSICLYSWLRFIATSDDQSCITCLIESDNNSIEKTKFTFTVL--VDAGHRPHLTFAPSSTVCQGSNFTMKCETNVPRPILYIYKLDPSFNIENPIIHLSNSTLFV--NNYNEDSKRSSQS-AEVLIKSMDFNYSGRYLC---SLAELPLFEIMHLSVIKC 371          
BLAST of FGFR1 vs. UniProt/SwissProt
Match: sp|Q8MY85|FGFR2_DUGJA (Fibroblast growth factor receptor 2 OS=Dugesia japonica OX=6161 GN=FGFR2 PE=2 SV=1)

HSP 1 Score: 214.542 bits (545), Expect = 1.771e-57
Identity = 114/277 (41.16%), Postives = 169/277 (61.01%), Query Frame = 3
Query: 1398 GVKLGEGNFGTVFLGSVDS-------RDVAIK-IPTEQG-QDM--LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYL------------QSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            G K+GEG FG V+   V S        +VAIK + T  G QD+  L  E+ MM+ IGRHRH++ L G C D G  + ++ELA  G+L+++L            Q+   L+      + +     ++++I +GM YLSS+ I+HRDLA RN+L+ +  ++KIADFGLTRIV NYY   ++   P +WMAPEC ++  +T KSDVWSYGIVLWEIFT+G  PY ++  + +  A+ NG+ N+KP ++   +Y LM   W  D   R TF++I+++L  +
Sbjct:  588 GSKIGEGAFGIVYSALVKSFSENSASVEVAIKTLHTSFGDQDVINLIQELEMMKIIGRHRHIISLYGACIDNGHPYMVIELAKHGNLRDFLRAQRSQSKVGEIQNSGGLVT----RLTVTDFLRFSIEIAEGMEYLSSRKIIHRDLAARNVLVDQYVEMKIADFGLTRIVENYYRKTTDGRLPIKWMAPECLLDRVYTVKSDVWSYGIVLWEIFTMGQTPYPTIQSDGMHQALRNGIRNEKPALASDEMYRLMLTIWNDDPLERHTFSEIIDKLTHI 860          
BLAST of FGFR1 vs. UniProt/SwissProt
Match: sp|Q91147|FGFR2_NOTVI (Fibroblast growth factor receptor 2 OS=Notophthalmus viridescens OX=8316 GN=FGFR2 PE=2 SV=1)

HSP 1 Score: 199.134 bits (505), Expect = 6.856e-53
Identity = 109/294 (37.07%), Postives = 163/294 (55.44%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV---------DSRDVAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INH-PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + K E PR  + + G  LGEG FG V +            D+  VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P        IN  P +++    L + T Q+ +GM YL+S+  +HRDLA RN+L+ E   +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y +M  CWR     RPTF  +V  L+ +
Sbjct:  376 LPEDPKWEYPREKLTL-GKPLGEGCFGQVVMAEAVGIDKDRPKDAATVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRTRRPPGMEYSFDINRIPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTETNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPGNCTNELYTMMTDCWRAVPSQRPTFKQLVEDLDRI 668          
BLAST of FGFR1 vs. UniProt/SwissProt
Match: sp|P16092|FGFR1_MOUSE (Fibroblast growth factor receptor 1 OS=Mus musculus OX=10090 GN=Fgfr1 PE=1 SV=2)

HSP 1 Score: 200.29 bits (508), Expect = 8.598e-53
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  465 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757          
BLAST of FGFR1 vs. UniProt/SwissProt
Match: sp|P11362|FGFR1_HUMAN (Fibroblast growth factor receptor 1 OS=Homo sapiens OX=9606 GN=FGFR1 PE=1 SV=3)

HSP 1 Score: 200.29 bits (508), Expect = 9.547e-53
Identity = 109/294 (37.07%), Postives = 165/294 (56.12%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL--------INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L  + + E+PR+ + V G  LGEG FG V L      D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YLQ+  P          ++P ++++   L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+ +
Sbjct:  465 LPEDPRWELPRDRL-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757          
BLAST of FGFR1 vs. TrEMBL
Match: H9CXV7 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 640.188 bits (1650), Expect = 0.000e+0
Identity = 307/311 (98.71%), Postives = 308/311 (99.04%), Query Frame = 3
Query:   48 MIKFNSSHFYWFIFIVEIVNGMFDFPSTDSCYEIRTFESKLSKLEYQTARLSCHINVIKRCRKGSVRWAWFKDNIQIKNGTRKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEK 980
            MIKFNSSHFYWFIFIVEIVNGMFDFPSTDSCYEIRTFESKLSKLEYQTARLSCHINVIKRCRKGSVRWAWFKDNIQIKNGT+KKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGS GHVNNRDRRTFGELIKTG  YEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEK
Sbjct:    1 MIKFNSSHFYWFIFIVEIVNGMFDFPSTDSCYEIRTFESKLSKLEYQTARLSCHINVIKRCRKGSVRWAWFKDNIQIKNGTQKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSLGHVNNRDRRTFGELIKTGXXYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEK 311          

HSP 2 Score: 271.552 bits (693), Expect = 2.612e-79
Identity = 127/129 (98.45%), Postives = 129/129 (100.00%), Query Frame = 3
Query: 1368 EIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIV 1754
            EIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKS++
Sbjct:  312 EIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSVI 440          
BLAST of FGFR1 vs. TrEMBL
Match: T1G069 (Protein kinase domain-containing protein OS=Helobdella robusta OX=6412 GN=20214467 PE=3 SV=1)

HSP 1 Score: 218.779 bits (556), Expect = 2.224e-61
Identity = 120/298 (40.27%), Postives = 174/298 (58.39%), Query Frame = 3
Query: 1335 DYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGS---VDSRD------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVI--NYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            DY  + ++   E PR  ++VS + LGEG FGTV++ +   VDS +      VA+K+  E   D     L  E+ MM+ IGRH++VL L+G C   G L+ I+E A+ G+L+++L+   P        ++  P   +    L T+ LQI KGM +L+SK  +HRDLA RN+L+ E+  +K+ADFGLTR V+  +YY   ++   P +WMAPE   + + T KSDVWSYGI+LWE+F+LG  PY S+   ++   +  G   + P  S   +Y LM  CW    D RP+F  IVN L SV
Sbjct:    2 DY-EIPLDKAWEFPREKLQVSSI-LGEGAFGTVYMATAVGVDSSNPEASTKVAVKMLKENASDQDVVDLVQEMEMMKIIGRHKNVLSLLGCCTQNGPLFVILEYAANGNLRDFLRDKRPKNFRLQNCVVEVPLDYLTYKDLVTFALQIAKGMEFLASKMCIHRDLAARNVLVCEDYTLKVADFGLTRNVLKSDYYKKKTDGRLPVKWMAPEALFDRKCTVKSDVWSYGILLWELFSLGGNPYPSVPVEKIFQLLKAGYRMEAPVYSSNEIYSLMLSCWHQSPDHRPSFNKIVNSLHSV 297          
BLAST of FGFR1 vs. TrEMBL
Match: H9CXV6 (FGFR4 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 230.335 bits (586), Expect = 1.004e-60
Identity = 120/278 (43.17%), Postives = 173/278 (62.23%), Query Frame = 3
Query: 1368 EIPRNHVKVSGVKLGEGNFGTVFLG---SVDSRDVAIKIPTEQGQDMLFD--------EVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEI-NLNQ--LFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            E PR+ +K++  KLGEG FG V+ G    +  +    K+  +  +D   D        E+ +M+ IGRH +V++L+GLC   G L  I+ELA  G+L+++++S N   +   + I NL    L TY+ QI  GM YL+S+S+VHRDL+ RNIL+ E+ ++KIADFGLTRIV  YY   ++   P +WMAPE  +E ++T KSDVWSYGI+LWEIFTLG  PY S+   +V D I  G  N +PE++   +Y LM+ CW    + RP F +IV  L+ +
Sbjct:  531 EFPRDKLKITNKKLGEGAFGMVYEGLTNDIAKKPTFTKVAVKMMRDDFSDSNVHDFVKEMEIMKHIGRHPNVIQLLGLCTQNGPLRVIVELAPYGNLRDFVRSKNNKYSKQKKNIENLTASILSTYSFQIANGMTYLASRSVVHRDLSARNILVGEHYEMKIADFGLTRIVDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDAPYSSILPEKVVDVIKKGFQNPQPELANFEIYSLMQHCWNISTENRPHFFEIVETLQDI 808          

HSP 2 Score: 62.003 bits (149), Expect = 5.394e-6
Identity = 86/356 (24.16%), Postives = 138/356 (38.76%), Query Frame = 3
Query:  195 RLSCHINVIKRCRKGSVRWAWFKDNIQIKNGTRKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIR-LNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNG-TCYDSDFK-INPYSKLYKYYTCAIGG------QLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFL-----IRKNHNEIILNTSVGRVEMVLKFADST----------------DTGIYLCR-----RESISERMMHLTVIPC 1157
             L C + V   C+   +   W KD   +  G + K   ++   +      +SD G Y C V N     S    + V+      K+I   + +P ++  + + + Y  P+M      + +   LS+ + L CQ    +K     + WY    H +  +    G+++ +  E  I+T   +C     LNI N   C  S+F  I P +    ++TC I        +   T+ I +   IFR       KL+F    T+C G  F  NCST +     L        R + N + L TS    E+V    DST                D+G Y C       +     +M+LTV+ C
Sbjct:   18 ELMCMVKVDISCQVTWLAMEWLKDGTFL--GKKVKILRKMKYIYKKKKLNVSDAGNYTCKVNNQFGESSLSYLVKVTEALSGSKLIENFHEIPSDLLEISQYKYYMHPEMKKG--NVKHVLSLSSIF-LNCQVL-FSKELYPRISWYQHSSHFDYEN----GKVLSSDDELFIETSEESCIPYTNLNISNDFICISSNFNYIVPDTFTETFFTCMIESNTSFVNKAKYTYVILIDQRIFRN------KLKFPKQLTVCHGSNFTLNCSTNEPRPVLLLFKLQPKSRLDLNNVDLRTSPLLTELVSN--DSTRSLKSMIWRFYSVSFNDSGRYFCTISPHVPDETQYELMNLTVVDC 355          
BLAST of FGFR1 vs. TrEMBL
Match: A0A0R3UM39 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS8788 PE=4 SV=1)

HSP 1 Score: 216.853 bits (551), Expect = 4.849e-59
Identity = 111/267 (41.57%), Postives = 161/267 (60.30%), Query Frame = 3
Query: 1368 EIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-----INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            E+PR+ V++ G ++G G FG V+ G+V         PT++  D L  E+ +++Q   H HV++L G+C   G L  ++ELA  G+L+++L    P       N P   ++   L ++ LQ+ KGM+YL+ ++I+HRDLA RNIL+      KIADFGLTR V +YY   S+   P +WMAPE   + R+T KSDVWS+GI+LWEIF+ G  PY +LS   +  A+  G  N++P  SP  VY LM  CW  D   RPTF+ +V  L+
Sbjct:   51 EVPRDRVRL-GRQIGAGAFGVVYEGTVSD-------PTKELAD-LVREMEILKQFNPHPHVIQLYGVCTQNGRLQVLVELAPYGNLRDFLMDRRPRRDQKSANQPFSHLSARHLVSFGLQVAKGMDYLARQNIIHRDLAARNILIGCRFVAKIADFGLTRSVCDYYRKCSDGRLPIKWMAPESIFDRRYTTKSDVWSFGILLWEIFSYGGTPYPTLSAESLLKALQMGFRNEQPLASPSHVYGLMLSCWSIDPACRPTFSQLVASLQ 308          
BLAST of FGFR1 vs. TrEMBL
Match: A0A158RDD1 (Protein kinase domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS394 PE=4 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 1.381e-56
Identity = 118/297 (39.73%), Postives = 169/297 (56.90%), Query Frame = 3
Query: 1368 EIPRNHVKVSGVKLGEGNFGTVFLG-----------------------SVDSRDVAIKIP----TEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP-----LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESVN 2162
            E+PR+ V++ G ++G G FG VF G                       S     VA+K      TEQ    L  E+ +++Q   H HV++L G+C   G L  ++ELA  G+L+++L    P     +IN P   ++   L ++ LQ+ +GM+YL+  +IVHRDLA RNIL+      KIADFGLTR V +YY   S+   P +WMAPE   + R+TAKSDVWS+GI+LWEIF+ G  PY +LS   +  A+  G+ N++P  SP  VY+LM  CW  D   RP+FA +V+ L+ V+
Sbjct:  327 EVPRDCVRL-GRQIGAGAFGVVFAGVISEPAKVLPGLRRGDPLDRSCCSAQELTVAVKTLRNNFTEQELADLVREMEILKQFEPHPHVIQLYGVCTQNGRLQMLVELAPYGNLRDFLMDRRPCAGQKMINQPLPRLSTGHLVSFGLQVARGMDYLARLNIVHRDLAARNILIGNRFVAKIADFGLTRSVCDYYRKCSDGRLPIKWMAPESIFDRRYTAKSDVWSFGILLWEIFSFGGTPYPTLSAEALLKALQLGLRNEQPLASPASVYNLMLACWSIDPAARPSFAHLVSSLQQVH 622          
BLAST of FGFR1 vs. Ensembl Cavefish
Match: fgfr1a (fibroblast growth factor receptor 1a [Source:NCBI gene;Acc:30705])

HSP 1 Score: 200.29 bits (508), Expect = 3.935e-54
Identity = 108/292 (36.99%), Postives = 164/292 (56.16%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINH--------PCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            L  + + E+PR+ + V G  LGEG FG V +G V   D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P            P + +++  L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   D+P      +Y +M+ CW      RPTF  +V  L+
Sbjct:  377 LPQDPRWELPRDKL-VLGKPLGEGCFGQVVMGEVLGMDKDKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFASKGNLREYLRARRPPGMEYCYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDRPTTCTHELYMMMRDCWHAIPSQRPTFKQLVEDLD 667          
BLAST of FGFR1 vs. Ensembl Cavefish
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:58129])

HSP 1 Score: 197.208 bits (500), Expect = 1.115e-52
Identity = 118/334 (35.33%), Postives = 176/334 (52.69%), Query Frame = 3
Query: 1251 LRRAFQLK-----NSNRVYV-TRRLVLKD--VIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            L+R   L+     NSN   V   RL   D  ++ N   + L  + K E PR+ + + G  LGEG FG V +      D         VA+K+  + G D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P + +    L +   Q+ +GM YL+S+  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V   + V
Sbjct:  422 LKRQVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPSDPKWEFPRSKLTL-GKALGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRV 754          
BLAST of FGFR1 vs. Ensembl Cavefish
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:58129])

HSP 1 Score: 196.823 bits (499), Expect = 1.250e-52
Identity = 115/321 (35.83%), Postives = 171/321 (53.27%), Query Frame = 3
Query: 1275 NSNRVYV-TRRLVLKD--VIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            NSN   V   RL   D  ++ N   + L  + K E PR+ + + G  LGEG FG V +      D         VA+K+  + G D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P + +    L +   Q+ +GM YL+S+  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V   + V
Sbjct:  434 NSNTPLVRIARLSSSDGPMLPNVSELELPSDPKWEFPRSKLTL-GKALGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRV 753          
BLAST of FGFR1 vs. Ensembl Cavefish
Match: fgfr4 (fibroblast growth factor receptor 4 [Source:NCBI gene;Acc:103029904])

HSP 1 Score: 193.356 bits (490), Expect = 4.640e-51
Identity = 105/296 (35.47%), Postives = 164/296 (55.41%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV-----DSRD----VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            I L  +   E PR ++ + G  LGEG FG V          D++D    VA+K+  +   D     L  E+ +M+ + +H++++ L+G+C  +G L+ ++E AS GSL+ YL++  P        +   P +++    L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y  M++CW      RPTF  +V +L+ V
Sbjct:  579 IELPYDPDWEFPRENLTL-GKPLGEGCFGQVVRADAYGINKDNQDQATTVAVKMLKDDATDKDLADLISEMELMKGMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTFKDLLSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRV 873          
BLAST of FGFR1 vs. Ensembl Cavefish
Match: fgfr2 (fibroblast growth factor receptor 2 [Source:NCBI gene;Acc:352940])

HSP 1 Score: 191.815 bits (486), Expect = 5.380e-51
Identity = 112/312 (35.90%), Postives = 169/312 (54.17%), Query Frame = 3
Query: 1293 VTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV---------DSRDVAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
             TRR    D I  P+Y  L  + + E  R+ + + G  LGEG FG V +            ++  VA+K+     TE+    L  E+ MM+ IGRH++++ L+G C  +G L+ I+E AS G+L+ YL++  P        +     + +    L + T Q+ +GM YL+S+  +HRDLA RN+L+ E+  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWS+G+++WEIFTLG  PY  +   E+   +  G   DKP      +Y +MK CW      RPTF  +V  L+ +
Sbjct:  416 TTRRSSDHDQII-PEY-DLPEDPRWEFSRDKLTL-GKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNDLYMMMKDCWHAISSQRPTFKQLVEDLDRI 724          
BLAST of FGFR1 vs. Ensembl Sea Lamprey
Match: fgfr2 (fibroblast growth factor receptor 2 [Source:NCBI gene;Acc:352940])

HSP 1 Score: 192.971 bits (489), Expect = 5.827e-53
Identity = 101/278 (36.33%), Postives = 155/278 (55.76%), Query Frame = 3
Query: 1398 GVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP---------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            G  LGEG FG V +      D         VA+K+  E   D     L  E+ MM+ IG+H++++ L+G C   G L+ I+E A+ G+L+ +L++  P               +++++ +L ++T Q+ +GM YL+SK  +HRDLA RN+L+ ++  +KIADFGL R V  I+YY   S    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   D+P +    +Y +MK CW      RPTF  +V  L+ +
Sbjct:  279 GKPLGEGCFGQVVMAEALGIDKEKPNRSLRVAVKMLKEDATDKDLYDLVSEMEMMKNIGKHKNIINLLGACTQGGPLYVIVEFAAKGNLREFLRARRPPGTEYTFEGAAAAQGEQLSIKELVSFTYQVARGMEYLASKKCIHRDLAARNVLVTDDNVMKIADFGLARDVNYIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDRPALCSTELYMMMKDCWAAVPSHRPTFKQLVEDLDRI 556          
BLAST of FGFR1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006670.1 (pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene:ENSPMAG00000006016.1 transcript:ENSPMAT00000006670.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 181.03 bits (458), Expect = 9.315e-51
Identity = 112/303 (36.96%), Postives = 170/303 (56.11%), Query Frame = 3
Query: 1272 KNSNRVYVT-RRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVD-SRDVAIKIPTEQG---QDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVI----NYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            +++N + VT  +  LK  +   + +S  +  K EIPR+ V++   +LG G FG V+ G  + +  VAIK   +QG   +D    E ++M+++ RH  +++L  +C  E  ++ I EL S GSL NYLQ+         + ++L +L     Q+  GM YL +++ +HRDLA RNIL+AE+   K+ADFGL R++     + Y +      P +W APE    NRF+ KSDVWS+G++L EI T G +PY   +  EV  A+  G     P   P+  YDLM +CW  D+  RPTF  +  QLE
Sbjct:   75 RDANGLCVTLNQPCLKKEMPQTEGLSSDMADKWEIPRSSVQLVK-RLGAGQFGEVWQGLWNKTTPVAIKT-LKQGTMDRDDFLREAQLMKRL-RHPKLIQLYAVCTQEEPIYIITELMSNGSLANYLQTPE------GRSLDLVELVDMAAQVAAGMAYLEAQNYIHRDLAARNILVAEHNACKVADFGLARVIKMSNEDEYEARVGSKFPIKWTAPEAANYNRFSIKSDVWSFGVLLHEIITYGKLPYPGQTNAEVLAAVDRGYRMPCPPGCPQAFYDLMLECWNVDDQARPTFETLQWQLE 368          
BLAST of FGFR1 vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032])

HSP 1 Score: 179.489 bits (454), Expect = 2.243e-50
Identity = 110/309 (35.60%), Postives = 155/309 (50.16%), Query Frame = 3
Query: 1320 VIQNPDYIS--LAINSKLEIPR----NHVKVSGV----KLGEGNFGTVFLGSVDSRDVA----------IKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP----LINHPCQEINL---NQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            VI+NP Y S  L       IP     +H+K   +    +LGEG FG V+L    S DV           +K  ++  +   + E  ++  + +H H++   G+C +   L  + E    G L  +L+   P    + + P  E  L    Q+     QI  GM YL+S+  VHRDLATRN L+     +KI DFG++R V   +YY        P RWM PE  +  +FTA SDVWS G+VLWEIFT G  P++ LS  EV D IC G + ++P   P  VY+LM  CW  +   R    DI+ +LES+
Sbjct:   43 VIENPQYFSDSLGPGKDAHIPEGYTAHHIKRQDIALMCELGEGAFGKVYLAECSSLDVGQEPMLVAAKTLKDLSDGARKDFYREAELLTNL-QHEHIVRFYGVCVEGEPLIMVFEYMKNGDLNKFLRLRGPDAVFMGDAPQAEPRLLSQAQMLNMGSQIAAGMAYLASQHFVHRDLATRNCLVGAGLVVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCICQGRVLERPRSCPMEVYELMLGCWHREPQHRLGIKDILARLESL 350          
BLAST of FGFR1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004129.1 (pep scaffold:Pmarinus_7.0:GL490249:304:4500:1 gene:ENSPMAG00000003774.1 transcript:ENSPMAT00000004129.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 173.326 bits (438), Expect = 3.637e-49
Identity = 96/268 (35.82%), Postives = 149/268 (55.60%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV-DSRDVAIKI-PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADI 2138
            +S+ + +   +PR+ +K+  + LG GNFG V+ G   D+ DVAIKI  T    D    EV+ M    +H +VL++  +C ++   W + EL   G++ +YL        H   E+   +       I  GM YLS K  +H DLA RNIL+ ++   K+ADFGL+  +   Y+  +    PF+WMAPE  ++ +FT KSDVWS+G++L+E+FT G  PY  +   +V+D I  G    +P+  P  VY +M++CW F+   RP F  +
Sbjct:    8 LSVELMNTWHVPRSSIKMGNL-LGRGNFGEVYEGRWNDTTDVAIKIVRTNSSFDTFMKEVKTMISF-KHENVLQIYAVCKEKWPYWIVTELVPYGNMLHYLGR----FGHELSEV---ERLYMAFGIASGMAYLSKKRCIHCDLAGRNILMGQHNICKVADFGLSHKLKEEYYDATGHVVPFQWMAPEVLIQLKFTRKSDVWSFGVLLYELFTDGKRPYADMDKQQVQDLIKCGGRLKRPDACPNVVYHIMQRCWNFEHRKRPPFCKL 266          
BLAST of FGFR1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009481.1 (pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009481.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 175.252 bits (443), Expect = 1.047e-47
Identity = 112/323 (34.67%), Postives = 170/323 (52.63%), Query Frame = 3
Query: 1275 NSNRVYVTRRLVLKDVIQNPDYISLA---INSKLEIPRNHVKVSGVKLGEGNFGTVFLG-------SVDSRDVAIKIPTEQG----QDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP-LINHPCQEIN-LNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESVNYYEYV*FTF 2189
            N N   V   ++   V  NP+Y S A   I  + E+ R+ VK+   +LG+G FG V+ G         D   VAIK   E      +    +E  +M+    H HV+ L+G+      +  IMEL + G LK+YL+S  P     P +  + L ++     +I  GM YL++K  VHRDLA RN ++AE+  +KI DFG+TR +   +YY    +   P RWM+PE   +  FT  SDVWS+G+VLWEI T    PY  LS  +V   + +G +   P   P  + +L++KCW+++  +RPTF +I++ L    +  +  F+F
Sbjct:   23 NRNEAAVPNGVLYASV--NPEYFSTADVYIADEWEVERDKVKMM-RELGQGTFGMVYEGLARGIVKGEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCH-HVVRLLGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEILDGLAPDLHPSFHEFSF 341          
BLAST of FGFR1 vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 94.3597 bits (233), Expect = 2.191e-20
Identity = 83/328 (25.30%), Postives = 148/328 (45.12%), Query Frame = 3
Query: 1326 QNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLG------------SVDSRDVAIKIPTEQGQ-------------------------------------DMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESR---PFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVY----DLMKKCWRFDEDLRPTFADIV 2141
            ++ D +SL   +K+  P+N +K  G  +G G+FG+V+LG             V+ ++  I +PT+  +                                     D L  E+ +++++  H +++   G   + G+L   +E   GGS+ + L +  P       E +L  +  +T QI  G+ YL  K+I+HRD+   NIL+   G +KI DFG+++ +       ++ +       WM+PE   +   TAK+D+WS G V+ E+FT G  P+   S  +   AI     N  PE+ P W      + ++K +  D   RP+  +++
Sbjct:  398 EDSDIVSLP--TKIATPKNWLK--GACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKEL-HHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPF------EESL--ITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT-GKHPFPDFSQMQ---AIFKIGTNTTPEI-PSWATSEGKNFLRKAFELDYQYRPSALELL 707          
BLAST of FGFR1 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 89.7373 bits (221), Expect = 6.765e-19
Identity = 59/204 (28.92%), Postives = 100/204 (49.02%), Query Frame = 3
Query: 1401 VKLGEGNFGTVFLGSVDSRDVAIKIP-----TEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGL-TRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYF 1994
            VK+G+G  G V+       +V++ I       +  ++++ +E+ +M+   +H +++  I     +G LW IME   GGSL + +  C          +   Q+     +   G+ +L SK ++HRD+ + NILL+  GDIK+ DFG   +I        +    P+ WMAPE      +  K D+WS GI++ E+   G  PY 
Sbjct:  624 VKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKG-SKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHC---------ILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPY-WMAPEVVSRKEYGPKVDIWSLGIMIIEMIE-GEPPYL 815          
BLAST of FGFR1 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 87.0409 bits (214), Expect = 4.781e-18
Identity = 66/245 (26.94%), Postives = 117/245 (47.76%), Query Frame = 3
Query: 1407 LGEGNFGTVFLGSVDSRD--VAIKIPTEQGQDMLFD---EVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPT 2126
            +G G++G V+       D  VAIK    +  + L D   E+ +++ +  H ++++  G       L+ ++E  + GSL+        LI+     ++ N+  TY  Q   G+ YL  + ++HRD+   NILL+ +  +K+ADFG++ IV +   +++       WMAPE       +  SD+WS G  + E+ T    PY +L+   +  A+ N      P      + D + KC+  +   RPT
Sbjct:   31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLN-HNNIVKYHGFIRKSYELYILLEYCANGSLRR-------LISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGT---LNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNP-PYHNLTDANIYYAVENDTYY-PPSSFSEPLKDFLSKCFVKNMYKRPT 262          
BLAST of FGFR1 vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 84.3445 bits (207), Expect = 7.736e-18
Identity = 71/259 (27.41%), Postives = 118/259 (45.56%), Query Frame = 3
Query: 1407 LGEGNFGTVFL--GSVDSRDVAIK------IPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            LG G+FG V L   + + R  A+K      I   +  +   DE RM+  I  H  ++ + G   D   ++ +M+   GG L + L+      N P  +        Y  ++   + YL SK I++RDL   NILL +NG IKI DFG  + V +  +++        ++APE      +    D WS+G++++E+   G  P+++ +  +  + I N  +   P   P    DL+KK      DL     ++ N  E V
Sbjct:   94 LGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLS-IVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPN-PVAKF-------YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTP---DYIAPEVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPFYNSNTMKTYENILNAELKFPPFFHPD-AQDLLKKL--ITRDLSERLGNLQNGSEDV 336          
BLAST of FGFR1 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 84.7297 bits (208), Expect = 3.032e-17
Identity = 78/294 (26.53%), Postives = 137/294 (46.60%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFL--GSVDSRDVAIK---IPTEQGQ--------DMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGS----LKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHS--MSEESRPFRWMAPECF-VENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLS-----FNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQ 2147
            I+ A NSK E  +    + G  +G+G+FG V+L         +A+K   +P    Q        + L  EV  ++ +  H ++++ +G           +E  +GGS    ++ Y +   PLI H             T Q+ KG+ YL SK I+HRD+   N+LL ++G  KI+DFG++R   + Y +  M+     F WMAPE    +  ++AK D+WS G ++ E+F  G  P+ +L      F   +      +  D   +  +   + +  C+  + + RPT  ++++ 
Sbjct: 1160 INKAKNSKGEY-KEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLD-HLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKH------------LTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVF-WMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSH 1437          
BLAST of FGFR1 vs. Ensembl Nematostella
Match: EDO49191 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHA4])

HSP 1 Score: 197.208 bits (500), Expect = 3.417e-54
Identity = 106/292 (36.30%), Postives = 175/292 (59.93%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVF------LGSVDSR-DVAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQS-------CNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLES 2156
            I L ++ + E+ R+ + + G+ LGEG FG V       L ++  R +VA+K+  E   +     L  E+ +M+ IG+H +++ LIG C  +G L+ ++E AS G+L+ +L++        NPL   P +++ L  L +++ Q+ +GM YL SK  +HRDLA RN+L+++N  IKIADFGL R +  I+YY   ++   P +WMA E   +  +TA+SDVW+YGI++WEI T G  PY  +   ++ + +  G   ++P      VY LM +CW  + + RPTFA+IV ++++
Sbjct:  308 IELPLDEEWELDRSQISLLGI-LGEGAFGRVVKADAIGLPNMPYRCNVAVKMLKEDATEHELADLVSEMEVMKTIGQHVNIINLIGACTQKGPLFVVVEYASQGNLRQFLRARRPIPEYANPLTEPPREKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLARDIHDIDYYRKTTDGRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPLWKLFELLKEGYRMEQPVNCQDDVYALMLRCWHENPNQRPTFAEIVKEMDA 598          
BLAST of FGFR1 vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8])

HSP 1 Score: 184.882 bits (468), Expect = 1.848e-52
Identity = 105/278 (37.77%), Postives = 152/278 (54.68%), Query Frame = 3
Query: 1398 GVKLGEGNFGTV-------FLGSVDSRD--VAIK----IPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLIN--------HPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVI--NYYHSMSEESR-PFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            G  +G G FG V         G  ++++  VA+K    + T + +     E+ MM+Q+G+H +++ ++G     G L  I E    G L+NYL++    ++         P +E+  N L ++  QI  GM YLS K  VHRDLA RNIL+ E+  +KI+DFGLTR V   + YH M    + P +WMAPE   +N  T KSDVW++G+VLWEI TLG  PY   S  E    + NG   +KP+M    +Y +M+ CW    + RPTF  + NQLE +
Sbjct:   21 GEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQL 298          
BLAST of FGFR1 vs. Ensembl Nematostella
Match: EDO47097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN91])

HSP 1 Score: 182.956 bits (463), Expect = 3.740e-52
Identity = 104/295 (35.25%), Postives = 157/295 (53.22%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSV------DSRDVAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFD--EGSLWAIMELASGGSLKNYLQ--------SCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESR--PFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L  N++ E PR+ +K+  + +G G FG VFL             VA K   E   D     L  E++++  IG H++++ L+G C    E  L  I+E    G+L N+L+        + +P    P +   L  L   + Q+ + M +L+S+  VHRDLA RN+L+ EN  +KIADFGL R +    H +   +   P +WMA E  V+  +T  SDVWS+G++LWEIFTLG  PY  L  NEV   +  G    +PE  P+ +YDLM +CW+ D   RPTF  ++  ++ +
Sbjct:    1 MKLPWNAEWEFPRDRIKLLDI-VGTGAFGQVFLAEAVGISNKQVTRVACKGLKENATDSEYRDLLSELKILMHIGEHKNIVNLLGACTKGRECDLLVIIEYCPHGNLLNFLRKRRDVFEATWSPPTEKPDETFTLTDLVITSFQVSRAMQFLASRRCVHRDLAARNVLVGENYVMKIADFGLARDIYKEEHYVKTTAGLLPVKWMAIEALVDQVYTHSSDVWSFGVLLWEIFTLGGSPYPGLPANEVYQYLMEGQRMAQPEDCPQEMYDLMLRCWQHDPAQRPTFTQLLETIDKI 294          
BLAST of FGFR1 vs. Ensembl Nematostella
Match: EDO49315 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHA0])

HSP 1 Score: 183.341 bits (464), Expect = 8.708e-52
Identity = 99/291 (34.02%), Postives = 163/291 (56.01%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTV-------FLGSVDSRDVAIKIPTEQGQDM-LFD---EVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-----INHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + +  + + E  R ++ +  V LGEG FG V         G+     VA+K+  E   +  LFD   E+ +M+ IG+H +++ L+G C   G L+ ++E A  G+L+ +L+   P+     +  P + + L  L T+  QI KGM YL+S+  +HRDLA RNIL+A++  +KIADFGL R V  ++YY   ++   P +WMA E   +  +T +SDVWS+GIV+WEI T G  PY  +   ++   +  G   ++P    + +Y++M+ CW  + + RPTF  +V   + +
Sbjct:   44 VEIEYDEEWEFDRTYLVIREV-LGEGAFGKVMRAEAFGLHGNSACTTVAVKMLKEDATEQELFDLVSEMEVMKSIGKHINIINLLGTCTQHGPLFVLVEYARWGNLRQFLRDRRPVKDYDDVMEPAETLTLLNLMTFCYQIAKGMEYLASRKCIHRDLAARNILVADDNILKIADFGLARDVHNVDYYRKTTDGRLPVKWMAFEALFDRVYTTQSDVWSFGIVVWEIITFGGTPYPGVPIEKLCMLLNTGYRMERPVNCSKELYEIMRNCWNENPEARPTFTSLVQAFDDL 333          
BLAST of FGFR1 vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3])

HSP 1 Score: 177.178 bits (448), Expect = 5.077e-50
Identity = 101/288 (35.07%), Postives = 152/288 (52.78%), Query Frame = 3
Query: 1338 YISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSR-------DVAIKIPTEQGQDMLFDEVRMMQQIGRHR-----HVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEI--NLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            + S+ I  + E+PR  +K+   +LG G+FG V+ G             VA+K  +E     + D +  +Q+    +     HV+ L+G+  D      +MEL   G LKN+L+S  P +     E    L Q+     +I  GM YL+++  VHRDLA RN ++  N  +KI DFG+TR +   +YY    +   P RWMAPE   +  FT+ SDVWS+G+V+WE+ TL   PY   S  EV   + +G +  KP+  P  ++DLM  CW+F    RPTF  I++ +E
Sbjct:    2 FPSVYIADEWEVPREKIKLIR-ELGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENAS--IRDRIEFLQEASIMKAFQCNHVVRLLGVVSDGQPTLVVMELMDNGDLKNFLRSHRPEVTMESDEPPPTLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPKPDDCPDRLFDLMTLCWQFSPKARPTFLSIISLIE 286          
BLAST of FGFR1 vs. Ensembl Medaka
Match: fgfr1 (fibroblast growth factor receptor 1 [Source:NCBI gene;Acc:100125448])

HSP 1 Score: 200.29 bits (508), Expect = 9.510e-54
Identity = 109/292 (37.33%), Postives = 164/292 (56.16%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPC--------QEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            L  + + E+PR+ + V G  LGEG FG V +G V   D         VA+K+     TE+    L  E+ MM+ IG+H++++ L+G C  +G L+ I+E AS G+L+ YL++  P     C        + +++  L +   Q+ +GM YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M+ CW      RPTF  +V  L+
Sbjct:  476 LPQDPRWEVPRDKL-VLGKPLGEGCFGQVMMGEVLGLDKEKPNRVTNVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCYNPDQVSVETMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLD 766          
BLAST of FGFR1 vs. Ensembl Medaka
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:100049424])

HSP 1 Score: 194.897 bits (494), Expect = 1.817e-52
Identity = 105/296 (35.47%), Postives = 160/296 (54.05%), Query Frame = 3
Query: 1341 ISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            + L  + K E PR  + + G  LGEG FG V +      D         VA K+  +   D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P +++    L +   Q+ +GM YL+S+  +HRDLA RN+L+ ++  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V  L+ +
Sbjct:  334 LELPSDPKWEFPRTRLTL-GKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAAKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEFASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDLDRI 628          
BLAST of FGFR1 vs. Ensembl Medaka
Match: ENSORLT00000000391.2 (fibroblast growth factor receptor 1-A [Source:NCBI gene;Acc:101155126])

HSP 1 Score: 194.126 bits (492), Expect = 3.332e-52
Identity = 105/292 (35.96%), Postives = 163/292 (55.82%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INHPC-QEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            L  +   E+PR+ + + G  LGEG FG V L      D         VA+K+     +E+    L  E+ MM+ IG+H++++ L+G C  EG L+ ++E AS G+L+ YL++  P+          P    + + +L +   Q+ +GM+YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   +KP    + +Y +M+ CW      RPTF  +V  L+
Sbjct:  377 LPYDPAWELPRDRLTL-GKPLGEGCFGQVVLAEAVGLDRSKPARLTKVAVKMLKADASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQEGPLYVVVEYASKGNLREYLRARRPVGGEYWSGARQPLLGGVEIRELVSAAYQVARGMSYLASKKCIHRDLAARNVLVTEDDVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMEKPSACTQELYLMMRDCWHAVPSRRPTFQQLVEDLD 667          
BLAST of FGFR1 vs. Ensembl Medaka
Match: ENSORLT00000040527.1 (fibroblast growth factor receptor 1-A [Source:NCBI gene;Acc:101155126])

HSP 1 Score: 194.512 bits (493), Expect = 4.068e-52
Identity = 105/292 (35.96%), Postives = 163/292 (55.82%), Query Frame = 3
Query: 1347 LAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKI----PTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPL-------INHPC-QEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLE 2153
            L  +   E+PR+ + + G  LGEG FG V L      D         VA+K+     +E+    L  E+ MM+ IG+H++++ L+G C  EG L+ ++E AS G+L+ YL++  P+          P    + + +L +   Q+ +GM+YL+SK  +HRDLA RN+L+ E+  +KIADFGL R +  I+YY   +    P +WMAPE   +  +T +SDVWS+G++LWEIFTLG  PY  +   E+   +  G   +KP    + +Y +M+ CW      RPTF  +V  L+
Sbjct:  377 LPYDPAWELPRDRLTL-GKPLGEGCFGQVVLAEAVGLDRSKPARLTKVAVKMLKADASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQEGPLYVVVEYASKGNLREYLRARRPVGGEYWSGARQPLLGGVEIRELVSAAYQVARGMSYLASKKCIHRDLAARNVLVTEDDVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMEKPSACTQELYLMMRDCWHAVPSRRPTFQQLVEDLD 667          
BLAST of FGFR1 vs. Ensembl Medaka
Match: fgfr3 (fibroblast growth factor receptor 3 [Source:NCBI gene;Acc:100049424])

HSP 1 Score: 195.282 bits (495), Expect = 5.213e-52
Identity = 155/530 (29.25%), Postives = 239/530 (45.09%), Query Frame = 3
Query:  819 YTCAIG---GQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEI--------------ILNTSVGRVEMV---LKFADST--DTGIYLCRR----------------ESISERMMH-------LTVIPCIIYTMLNXXXXXXXXXXXXXXXXXXXXXSKRLRRAFQLK------------NSNRVYV-TRRLVLKD--VIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRD---------VAIKIPTEQGQDM----LFDEVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNP--------LINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIV--INYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            YTC +    G +++T+Q+DV   + R       +     N T+  G    F+C    YSD    +    H E+              IL ++V R  +    LK  + T  D G Y CR                 ES+S   +        + V  C+++ +L   I     +             ++L + F LK            NSN   V   RL   D  ++ N   + L  + K E PR  + + G  LGEG FG V +      D         VA K+  +   D     L  E+ MM+ IG+H++++ L+G C  +G L+ ++E AS G+L+ YL++  P            P +++    L +   Q+ +GM YL+S+  +HRDLA RN+L+ ++  +KIADFGL R V  I+YY   +    P +WMAPE   +  +T +SDVWSYG++LWEIFTLG  PY  +   E+   +  G   DKP      +Y +M++CW      RPTF  +V  L+ +
Sbjct:  238 YTCVVQNKYGTISQTYQLDV---LERSPHRPILQAGLPANQTVFVGNDVEFHCKV--YSDAQPHIQWLKHIEVNGTRYGPDGVPYVNILKSNVSRQTVTHSKLKLFNVTEKDEGKYWCRASNFVGKSEKAFWLEVTESVSNPKLEDEYADILIYVTGCVLF-ILAVVIVILCRMRMTTQKTVPAPPVQKLSK-FPLKRQQVSLDSNSSMNSNTPLVRIARLSSSDGPMLANVLELELPSDPKWEFPRTRLTL-GKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAAKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEFASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDLDRI 759          
BLAST of FGFR1 vs. Planmine SMEST
Match: SMESG000036590.1 (SMESG000036590.1)

HSP 1 Score: 983.015 bits (2540), Expect = 0.000e+0
Identity = 498/504 (98.81%), Postives = 501/504 (99.40%), Query Frame = 3
Query:   69 HFYWFIFIVEIVNGMFDFPSTDSCYEIRTFESKLSKLEYQTARLSCHINVIKRCRKGSVRWAWFKDNIQIKNGTRKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNXXXXXXXXXXXXXXXXXXXXXSKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDE 1580
            HFYWFIFIVEIVNGMFDF STDSCYEIRTFESK+SKLEYQTARLSCHINVIK+CRKGSVRWAWFKDNIQIKNGT+KKTR QIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNR RRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDE
Sbjct:    6 HFYWFIFIVEIVNGMFDFLSTDSCYEIRTFESKISKLEYQTARLSCHINVIKKCRKGSVRWAWFKDNIQIKNGTQKKTRFQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRYRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDE 509          
BLAST of FGFR1 vs. Planmine SMEST
Match: SMESG000036590.1 (SMESG000036590.1)

HSP 1 Score: 981.474 bits (2536), Expect = 0.000e+0
Identity = 500/511 (97.85%), Postives = 505/511 (98.83%), Query Frame = 3
Query:   57 FNSSHFYWFIFIVEIVNGMFDFPSTDSCYEIRTFESKLSKLEYQTARLSCHINVIKRCRKGSVRWAWFKDNIQIKNGTRKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNXXXXXXXXXXXXXXXXXXXXXSKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGSL 1589
            F   HFYWFIFIVEIVNGMFDF STDSCYEIRTFESK+SKLEYQTARLSCHINVIK+CRKGSVRWAWFKDNIQIKNGT+KKTR QIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNR RRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEG++
Sbjct:    2 FLLGHFYWFIFIVEIVNGMFDFLSTDSCYEIRTFESKISKLEYQTARLSCHINVIKKCRKGSVRWAWFKDNIQIKNGTQKKTRFQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRYRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDEGNI 512          
BLAST of FGFR1 vs. Planmine SMEST
Match: SMESG000036590.1 (SMESG000036590.1)

HSP 1 Score: 952.199 bits (2460), Expect = 0.000e+0
Identity = 484/490 (98.78%), Postives = 487/490 (99.39%), Query Frame = 3
Query:  111 MFDFPSTDSCYEIRTFESKLSKLEYQTARLSCHINVIKRCRKGSVRWAWFKDNIQIKNGTRKKTRSQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNXXXXXXXXXXXXXXXXXXXXXSKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDE 1580
            MFDF STDSCYEIRTFESK+SKLEYQTARLSCHINVIK+CRKGSVRWAWFKDNIQIKNGT+KKTR QIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNR RRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDE
Sbjct:    1 MFDFLSTDSCYEIRTFESKISKLEYQTARLSCHINVIKKCRKGSVRWAWFKDNIQIKNGTQKKTRFQIYIEHLIYNTTMSDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEKRTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGHVNNRYRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINPYSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAGQKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGIYLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISKRLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVSGVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRHVLELIGLCFDE 490          
BLAST of FGFR1 vs. Planmine SMEST
Match: SMESG000036598.1 (SMESG000036598.1)

HSP 1 Score: 409.068 bits (1050), Expect = 1.132e-139
Identity = 193/193 (100.00%), Postives = 193/193 (100.00%), Query Frame = 3
Query: 1599 MELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESVNYYEYV 2177
            MELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESVNYYEYV
Sbjct:    1 MELASGGSLKNYLQSCNPLINHPCQEINLNQLFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESVNYYEYV 193          
BLAST of FGFR1 vs. Planmine SMEST
Match: SMESG000054557.1 (SMESG000054557.1)

HSP 1 Score: 230.335 bits (586), Expect = 2.089e-64
Identity = 120/278 (43.17%), Postives = 173/278 (62.23%), Query Frame = 3
Query: 1368 EIPRNHVKVSGVKLGEGNFGTVFLG---SVDSRDVAIKIPTEQGQDMLFD--------EVRMMQQIGRHRHVLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEI-NLNQ--LFTYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINYYHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFSLSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQLESV 2159
            E PR+ +K++  KLGEG FG V+ G    +  +    K+  +  +D   D        E+ +M+ IGRH +V++L+GLC   G L  I+ELA  G+L+++++S N   +   + I NL    L TY+ QI  GM YL+S+S+VHRDL+ RNIL+ E+ ++KIADFGLTRIV  YY   ++   P +WMAPE  +E ++T KSDVWSYGI+LWEIFTLG  PY S+   +V D I  G  N +PE++   +Y LM+ CW    + RP F +IV  L+ +
Sbjct:  515 EFPRDKLKITNKKLGEGAFGMVYEGLTNDIAKKPTFTKVAVKMMRDDFSDSNVHDFVKEMEIMKHIGRHPNVIQLLGLCTQNGPLRVIVELAPYGNLRDFVRSKNNKYSKQKKNIENLTASILSTYSFQIANGMTYLASRSVVHRDLSARNILVGEHYEMKIADFGLTRIVDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDAPYSSILPEKVVDVIKKGFQNPQPELANFEIYSLMQHCWNISTENRPHFFEIVETLQDI 792          
The following BLAST results are available for this feature:
BLAST of FGFR1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FGFR22.144e-5436.73fibroblast growth factor receptor 2 [Source:HGNC S... [more]
FGFR17.334e-5437.07fibroblast growth factor receptor 1 [Source:HGNC S... [more]
FGFR17.477e-5437.07fibroblast growth factor receptor 1 [Source:HGNC S... [more]
FGFR17.809e-5437.07fibroblast growth factor receptor 1 [Source:HGNC S... [more]
FGFR29.992e-5436.73fibroblast growth factor receptor 2 [Source:HGNC S... [more]
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BLAST of FGFR1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
R151.12.396e-4634.81pep chromosome:WBcel235:III:7218813:7221186:1 gene... [more]
csk-15.271e-4634.17Tyrosine-protein kinase csk-1 [Source:UniProtKB/S... [more]
csk-15.271e-4634.17Tyrosine-protein kinase csk-1 [Source:UniProtKB/S... [more]
csk-11.333e-4534.17Tyrosine-protein kinase csk-1 [Source:UniProtKB/S... [more]
csk-11.333e-4534.17Tyrosine-protein kinase csk-1 [Source:UniProtKB/S... [more]
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BLAST of FGFR1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
htl2.127e-5237.59gene:FBgn0010389 transcript:FBtr0083550[more]
htl2.127e-5237.59gene:FBgn0010389 transcript:FBtr0083549[more]
htl2.127e-5237.59gene:FBgn0010389 transcript:FBtr0083548[more]
btl1.532e-4934.29gene:FBgn0285896 transcript:FBtr0100676[more]
btl1.532e-4934.29gene:FBgn0285896 transcript:FBtr0075778[more]
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BLAST of FGFR1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fgfr31.161e-5435.64fibroblast growth factor receptor 3 [Source:NCBI g... [more]
fgfr1b5.250e-5338.27fibroblast growth factor receptor 1b [Source:ZFIN;... [more]
fgfr1b5.366e-5338.27fibroblast growth factor receptor 1b [Source:ZFIN;... [more]
fgfr37.398e-5234.53fibroblast growth factor receptor 3 [Source:NCBI g... [more]
fgfr37.849e-5234.53fibroblast growth factor receptor 3 [Source:NCBI g... [more]
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BLAST of FGFR1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fgfr44.410e-5437.16fibroblast growth factor receptor 4 [Source:NCBI g... [more]
fgfr48.594e-5437.16fibroblast growth factor receptor 4 [Source:NCBI g... [more]
fgfr48.613e-5437.16fibroblast growth factor receptor 4 [Source:NCBI g... [more]
fgfr49.678e-5437.16fibroblast growth factor receptor 4 [Source:NCBI g... [more]
fgfr41.063e-5337.16fibroblast growth factor receptor 4 [Source:NCBI g... [more]
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BLAST of FGFR1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fgfr21.589e-5436.73fibroblast growth factor receptor 2 [Source:MGI Sy... [more]
Fgfr21.776e-5436.73fibroblast growth factor receptor 2 [Source:MGI Sy... [more]
Fgfr14.891e-5437.07fibroblast growth factor receptor 1 [Source:MGI Sy... [more]
Fgfr14.891e-5437.07fibroblast growth factor receptor 1 [Source:MGI Sy... [more]
Fgfr14.891e-5437.07fibroblast growth factor receptor 1 [Source:MGI Sy... [more]
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BLAST of FGFR1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8MY86|FGFR1_DUGJA2.245e-6243.37Fibroblast growth factor receptor 1 OS=Dugesia jap... [more]
sp|Q8MY85|FGFR2_DUGJA1.771e-5741.16Fibroblast growth factor receptor 2 OS=Dugesia jap... [more]
sp|Q91147|FGFR2_NOTVI6.856e-5337.07Fibroblast growth factor receptor 2 OS=Notophthalm... [more]
sp|P16092|FGFR1_MOUSE8.598e-5337.07Fibroblast growth factor receptor 1 OS=Mus musculu... [more]
sp|P11362|FGFR1_HUMAN9.547e-5337.07Fibroblast growth factor receptor 1 OS=Homo sapien... [more]
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BLAST of FGFR1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
H9CXV72.612e-7998.71Receptor protein-tyrosine kinase OS=Schmidtea medi... [more]
T1G0692.224e-6140.27Protein kinase domain-containing protein OS=Helobd... [more]
H9CXV61.004e-6043.17FGFR4 (Fragment) OS=Schmidtea mediterranea OX=7932... [more]
A0A0R3UM394.849e-5941.57Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A158RDD11.381e-5639.73Protein kinase domain-containing protein OS=Hydati... [more]
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BLAST of FGFR1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fgfr1a3.935e-5436.99fibroblast growth factor receptor 1a [Source:NCBI ... [more]
fgfr31.115e-5235.33fibroblast growth factor receptor 3 [Source:NCBI g... [more]
fgfr31.250e-5235.83fibroblast growth factor receptor 3 [Source:NCBI g... [more]
fgfr44.640e-5135.47fibroblast growth factor receptor 4 [Source:NCBI g... [more]
fgfr25.380e-5135.90fibroblast growth factor receptor 2 [Source:NCBI g... [more]
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BLAST of FGFR1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fgfr25.827e-5336.33fibroblast growth factor receptor 2 [Source:NCBI g... [more]
ENSPMAT00000006670.19.315e-5136.96pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene... [more]
NTRK22.243e-5035.60neurotrophic receptor tyrosine kinase 2 [Source:HG... [more]
ENSPMAT00000004129.13.637e-4935.82pep scaffold:Pmarinus_7.0:GL490249:304:4500:1 gene... [more]
ENSPMAT00000009481.11.047e-4734.67pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene... [more]
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BLAST of FGFR1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
STE112.191e-2025.30Signal transducing MEK kinase; involved in pheromo... [more]
STE206.765e-1928.92Cdc42p-activated signal transducing kinase; involv... [more]
CDC154.781e-1826.94Protein kinase of the Mitotic Exit Network; locali... [more]
TPK37.736e-1827.41cAMP-dependent protein kinase catalytic subunit; p... [more]
BCK13.032e-1726.53MAPKKK acting in the protein kinase C signaling pa... [more]
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BLAST of FGFR1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO491913.417e-5436.30Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO491261.848e-5237.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO470973.740e-5235.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493158.708e-5234.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476525.077e-5035.07Tyrosine-protein kinase receptor [Source:UniProtK... [more]
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BLAST of FGFR1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fgfr19.510e-5437.33fibroblast growth factor receptor 1 [Source:NCBI g... [more]
fgfr31.817e-5235.47fibroblast growth factor receptor 3 [Source:NCBI g... [more]
ENSORLT00000000391.23.332e-5235.96fibroblast growth factor receptor 1-A [Source:NCBI... [more]
ENSORLT00000040527.14.068e-5235.96fibroblast growth factor receptor 1-A [Source:NCBI... [more]
fgfr35.213e-5229.25fibroblast growth factor receptor 3 [Source:NCBI g... [more]
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BLAST of FGFR1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000036590.10.000e+098.81SMESG000036590.1[more]
SMESG000036590.10.000e+097.85SMESG000036590.1[more]
SMESG000036590.10.000e+098.78SMESG000036590.1[more]
SMESG000036598.11.132e-139100.00SMESG000036598.1[more]
SMESG000054557.12.089e-6443.17SMESG000054557.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30034490
GenBankAFD29628.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034490 ID=SMED30034490|Name=FGFR1|organism=Schmidtea mediterranea sexual|type=transcript|length=2276bp
ATTCAATAAATTTTTAGATATTTTTTGTGAATATAAAGTATTATGAAATG
ATTAAATTTAATTCCAGTCATTTTTATTGGTTTATTTTCATTGTCGAAAT
AGTTAATGGAATGTTCGATTTTCCATCAACAGATTCATGTTATGAAATTA
GAACATTTGAATCAAAACTTTCTAAGCTTGAATATCAAACAGCTAGACTA
TCTTGTCACATCAATGTTATAAAAAGGTGTCGGAAAGGATCTGTACGATG
GGCTTGGTTTAAAGATAATATTCAAATAAAAAATGGCACCCGGAAAAAAA
CTCGTTCTCAAATTTATATAGAGCATTTAATATATAATACAACAATGAGC
GATACTGGAGAATATCATTGTTTAGTGCAAAATAATGTCTTCAATTATAG
TCAATATGTAAATTTGTCAGTTTCAGTGGGAACTCCAGAATTGAAAGTCA
TCCGGTTAAATACAGTACCCCTAAACATTTCAGTGTTGGAAGAGAAGCGC
ACTTATTGGATGCCGAAAATGACAACTGAATTATACGAAATTAGTTATAA
GTTTGAGTTATCCAATACTTACAGACTTCAGTGTCAATTCTTTTCATTAG
CAAAGTTAAATATCAGCAGTGTCAGATGGTACGGTAGCTGGGGCCATGTA
AATAATAGAGATAGAAGAACTTTCGGAGAACTCATTAAAACCGGTTCCGA
GTATGAAATCAAAACAATTCCTTATAATTGTAATCAAGAAAAATTCTTGA
ATATCAAAAATGGAACTTGCTATGACAGTGATTTCAAGATAAATCCATAT
TCAAAGCTTTATAAATATTACACATGTGCCATTGGCGGTCAATTAAACAG
AACTCATCAAATTGATGTTAAGAATTACATTTTCAGACAAGTTGATCTTT
CTAATGAGAAATTACGTTTCACAGGAAATTCTACCATCTGTGCCGGACAA
AAGTTTATTTTTAATTGCTCAACAGAAAAATATTCTGATACAAATTTATT
TTTAATCAGAAAAAATCACAATGAAATTATATTAAATACTTCAGTTGGGA
GAGTTGAGATGGTTTTGAAATTTGCAGATTCGACTGATACTGGGATATAT
TTGTGCAGAAGGGAAAGTATTTCAGAAAGAATGATGCATTTAACTGTAAT
TCCCTGTATCATTTATACTATGTTGAATTTCGCAATACCATTTTTCATAA
TGATAATAGCATTTATATTGCTTTTTGGAATATTTGTAATCTCTAAACGC
CTTAGAAGGGCTTTTCAGTTAAAAAATTCAAACCGTGTATATGTTACGCG
TCGACTGGTTCTAAAAGATGTCATTCAGAATCCTGATTACATTTCCTTGG
CGATAAATTCAAAATTAGAAATTCCCAGAAATCATGTAAAGGTTTCTGGA
GTAAAATTGGGTGAAGGTAATTTTGGCACTGTTTTCCTTGGTTCGGTAGA
TTCCAGAGATGTTGCCATAAAAATTCCGACCGAACAGGGACAAGACATGC
TGTTTGATGAAGTACGAATGATGCAACAAATCGGTCGCCATCGGCACGTA
CTCGAGTTAATTGGACTCTGTTTTGATGAAGGTTCTCTTTGGGCTATAAT
GGAACTAGCGTCTGGAGGAAGCTTGAAAAATTACCTTCAGTCATGTAATC
CTTTAATAAATCATCCTTGTCAAGAAATAAATCTCAATCAACTTTTTACT
TATACCTTGCAAATCGGAAAAGGAATGAATTATTTGTCTTCGAAATCAAT
TGTCCACAGGGATTTGGCGACCCGTAATATCTTGCTAGCTGAAAATGGTG
ATATTAAAATAGCTGATTTCGGCTTGACGAGAATTGTCATAAATTACTAT
CACAGCATGTCAGAAGAGTCTCGACCGTTTCGGTGGATGGCACCAGAATG
CTTTGTTGAAAATAGATTTACAGCTAAAAGTGATGTTTGGTCTTATGGAA
TTGTGCTTTGGGAAATTTTCACATTAGGTGTCATTCCGTATTTTTCTCTG
TCGTTTAATGAAGTACGCGACGCAATTTGCAATGGCGTTATCAATGATAA
ACCAGAAATGTCACCAAGATGGGTTTATGATTTAATGAAGAAATGCTGGA
GGTTTGATGAGGATTTGAGACCAACATTTGCAGATATTGTCAACCAACTG
GAAAGTGTGAATTACTACGAATATGTTTAATTTACTTTTCTAATGTTAAT
ATTGTAAATTTTTGTATAATGTATTTTGTATATTACGTTTTGACGTTTTT
TTGGTCAATAAATAATGTTTTTTTTT
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protein sequence of SMED30034490-orf-1

>SMED30034490-orf-1 ID=SMED30034490-orf-1|Name=SMED30034490-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=711bp
MIKFNSSHFYWFIFIVEIVNGMFDFPSTDSCYEIRTFESKLSKLEYQTAR
LSCHINVIKRCRKGSVRWAWFKDNIQIKNGTRKKTRSQIYIEHLIYNTTM
SDTGEYHCLVQNNVFNYSQYVNLSVSVGTPELKVIRLNTVPLNISVLEEK
RTYWMPKMTTELYEISYKFELSNTYRLQCQFFSLAKLNISSVRWYGSWGH
VNNRDRRTFGELIKTGSEYEIKTIPYNCNQEKFLNIKNGTCYDSDFKINP
YSKLYKYYTCAIGGQLNRTHQIDVKNYIFRQVDLSNEKLRFTGNSTICAG
QKFIFNCSTEKYSDTNLFLIRKNHNEIILNTSVGRVEMVLKFADSTDTGI
YLCRRESISERMMHLTVIPCIIYTMLNFAIPFFIMIIAFILLFGIFVISK
RLRRAFQLKNSNRVYVTRRLVLKDVIQNPDYISLAINSKLEIPRNHVKVS
GVKLGEGNFGTVFLGSVDSRDVAIKIPTEQGQDMLFDEVRMMQQIGRHRH
VLELIGLCFDEGSLWAIMELASGGSLKNYLQSCNPLINHPCQEINLNQLF
TYTLQIGKGMNYLSSKSIVHRDLATRNILLAENGDIKIADFGLTRIVINY
YHSMSEESRPFRWMAPECFVENRFTAKSDVWSYGIVLWEIFTLGVIPYFS
LSFNEVRDAICNGVINDKPEMSPRWVYDLMKKCWRFDEDLRPTFADIVNQ
LESVNYYEYV*
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Aliases
The feature 'FGFR1' has the following synonyms
Synonym
FGFR1
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0008543fibroblast growth factor receptor signaling pathway
GO:0006468protein phosphorylation
GO:0016310phosphorylation
GO:0018108peptidyl-tyrosine phosphorylation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000016pharynx
PLANA:0000429neoblast
PLANA:0002032epidermal cell
PLANA:0002075pigment cell
PLANA:0002109X1 cell
PLANA:0002111X2 cell
PLANA:0002142parenchyma
Vocabulary: INTERPRO
TermDefinition
IPR036179Ig-like_dom_sf
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR003599Ig_sub
IPR020635Tyr_kinase_cat_dom
IPR013783Ig-like_fold
IPR013151Immunoglobulin
IPR017441Protein_kinase_ATP_BS
IPR008266Tyr_kinase_AS
IPR000719Prot_kinase_dom
IPR007110Ig-like_dom
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0005524ATP binding
GO:0005515protein binding
GO:0000166nucleotide binding
GO:0004714transmembrane receptor protein tyrosine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPRINTSPR00109TYRKINASEcoord: 628..650
score: 60.48
coord: 609..619
score: 49.86
coord: 518..531
score: 40.13
coord: 562..580
score: 57.71
coord: 672..694
score: 41.45
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPFAMPF07714Pkinase_Tyrcoord: 452..701
e-value: 2.7E-77
score: 259.5
IPR003599Immunoglobulin subtypeSMARTSM00409IG_3ccoord: 292..368
e-value: 99.0
score: 2.8
coord: 38..126
e-value: 6.7E-5
score: 32.3
IPR020635Tyrosine-protein kinase, catalytic domainSMARTSM00219tyrkin_6coord: 448..701
e-value: 3.6E-98
score: 342.1
IPR013783Immunoglobulin-like foldGENE3DG3DSA:2.60.40.10coord: 36..130
e-value: 1.3E-8
score: 36.6
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 444..707
e-value: 2.6E-74
score: 251.6
NoneNo IPR availablePIRSFPIRSF000615TyrPK_CSF1-Rcoord: 531..709
e-value: 4.1E-51
score: 171.8
coord: 428..540
e-value: 1.3E-6
score: 24.5
coord: 32..149
e-value: 0.081
score: 8.6
coord: 247..377
e-value: 12.0
score: 1.4
NoneNo IPR availablePANTHERPTHR24418TYROSINE-PROTEIN KINASEcoord: 271..703
NoneNo IPR availableCDDcd00096Igcoord: 70..122
e-value: 2.03947E-5
score: 41.0737
NoneNo IPR availableCDDcd00192PTKccoord: 453..702
e-value: 2.01811E-106
score: 322.566
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..21
score: 0.554
NoneNo IPR availableTMHMMTMhelixcoord: 630..652
NoneNo IPR availableTMHMMTMhelixcoord: 377..399
IPR013151ImmunoglobulinPFAMPF00047igcoord: 42..118
e-value: 5.0E-5
score: 23.4
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 454..475
IPR008266Tyrosine-protein kinase, active sitePROSITEPS00109PROTEIN_KINASE_TYRcoord: 568..580
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 47..124
score: 8.629
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 448..710
score: 38.789
IPR036179Immunoglobulin-like domain superfamilySUPERFAMILYSSF48726Immunoglobulincoord: 38..126
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 418..701