E3 ubiquitin-protein ligase CBL

Overview
NameE3 ubiquitin-protein ligase CBL
Smed IDSMED30034412
Length (bp)1795
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of E3 ubiquitin-protein ligase CBL (SMED30034412) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase CBL (SMED30034412) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase CBL (SMED30034412) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase CBL (SMED30034412) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30034412

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 16

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30034412SMESG000039019.1 Contig3731GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30034412SMESG000039019.1 Contig3731GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30034412SMESG000039019.1 Contig3731GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30034412SMESG000056433.1 Contig3731GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30034412SMESG000056433.1 Contig3731GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30034412SMESG000056433.1 Contig3731GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
anterior sideSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30034412SMESG000056433.1 dd_Smed_v4_6780_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30034412SMESG000056433.1 Contig48324uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30034412SMESG000056433.1 Contig48324newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30034412SMESG000011837.1 SMESG000056433.1 OX_Smed_1.0.10563ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Human
Match: CBL (Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541])

HSP 1 Score: 388.652 bits (997), Expect = 4.312e-124
Identity = 173/368 (47.01%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   81 PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 443
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Human
Match: CBL (Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541])

HSP 1 Score: 387.882 bits (995), Expect = 5.220e-124
Identity = 173/368 (47.01%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   79 PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 441
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Human
Match: CBL (Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541])

HSP 1 Score: 387.111 bits (993), Expect = 8.998e-124
Identity = 173/368 (47.01%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   81 PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 443
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Human
Match: CBL (Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541])

HSP 1 Score: 387.882 bits (995), Expect = 1.127e-123
Identity = 173/368 (47.01%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   81 PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 443
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Human
Match: CBLB (Cbl proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:1542])

HSP 1 Score: 377.867 bits (969), Expect = 3.687e-121
Identity = 174/369 (47.15%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +     PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ ++   +
Sbjct:   71 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSR 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Celegans
Match: sli-1 (Suppressor of LIneage defect [Source:UniProtKB/TrEMBL;Acc:Q95ZR5])

HSP 1 Score: 300.056 bits (767), Expect = 1.212e-94
Identity = 155/392 (39.54%), Postives = 233/392 (59.44%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLN-DLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGL--TCPFCRLEIKSVEDIVVK-----PYEMKESADKLTA--------PPLPPR 1419
            PPF++  + D      +++  +    D L    Y K+ L ++I++ + +IKLFK     I    S  R+KLTK+SL FSH+       F +G Y  + FR+TK +A ++W  +F  K I+ W  F+ +L   +       +   LK+TI+L  +++++ +EFDVF RL+ P+  +++ W+ L   HPGY +F+TYD+VK  L    + PG  +Y+FR SCT+ GQWAIGY+  D +I QTI QNKSL +AL +G KEG+Y YPNG    +   +L  L+       +QV+ EQY++YCEM +TFELCKIC +N+KNI++EPC HLLC  CL +W+ S G   TCPFCR EIK    +++      P E++++ +   A        P +PPR
Sbjct:   77 PPFILDILPDT---YTHLMLIFTQNNDILQDNDYLKIFLESMINKCKEIIKLFKTSA--IYNDQSEERRKLTKMSLTFSHMLFEIKALFPEGIYIEDRFRMTKKEAESFWSHHFTKKNIVPWSTFFTALEKHHGSTIGKMEAAELKATIDLSGDDFISNFEFDVFTRLFYPFKTLIKNWQTLTTAHPGYCAFLTYDEVKKRLEKLTKKPG--SYIFRLSCTRPGQWAIGYVAPDGKIYQTIPQNKSLIQALHEGHKEGFYIYPNGR---DQDINLSKLMDVPQADRVQVTSEQYELYCEMGTTFELCKICDDNEKNIKIEPCGHLLCAKCLANWQDSDGGGNTCPFCRYEIKGTNRVIIDRFKPTPVEIEKAKNVAAAEKKLISLVPDVPPR 458
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Celegans
Match: sli-1 (Suppressor of LIneage defect [Source:UniProtKB/TrEMBL;Acc:Q95ZR5])

HSP 1 Score: 300.442 bits (768), Expect = 2.939e-94
Identity = 155/392 (39.54%), Postives = 233/392 (59.44%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLN-DLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGL--TCPFCRLEIKSVEDIVVK-----PYEMKESADKLTA--------PPLPPR 1419
            PPF++  + D      +++  +    D L    Y K+ L ++I++ + +IKLFK     I    S  R+KLTK+SL FSH+       F +G Y  + FR+TK +A ++W  +F  K I+ W  F+ +L   +       +   LK+TI+L  +++++ +EFDVF RL+ P+  +++ W+ L   HPGY +F+TYD+VK  L    + PG  +Y+FR SCT+ GQWAIGY+  D +I QTI QNKSL +AL +G KEG+Y YPNG    +   +L  L+       +QV+ EQY++YCEM +TFELCKIC +N+KNI++EPC HLLC  CL +W+ S G   TCPFCR EIK    +++      P E++++ +   A        P +PPR
Sbjct:   77 PPFILDILPDT---YTHLMLIFTQNNDILQDNDYLKIFLESMINKCKEIIKLFKTSA--IYNDQSEERRKLTKMSLTFSHMLFEIKALFPEGIYIEDRFRMTKKEAESFWSHHFTKKNIVPWSTFFTALEKHHGSTIGKMEAAELKATIDLSGDDFISNFEFDVFTRLFYPFKTLIKNWQTLTTAHPGYCAFLTYDEVKKRLEKLTKKPG--SYIFRLSCTRPGQWAIGYVAPDGKIYQTIPQNKSLIQALHEGHKEGFYIYPNGR---DQDINLSKLMDVPQADRVQVTSEQYELYCEMGTTFELCKICDDNEKNIKIEPCGHLLCAKCLANWQDSDGGGNTCPFCRYEIKGTNRVIIDRFKPTPVEIEKAKNVAAAEKKLISLVPDVPPR 458
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Celegans
Match: sli-1 (Suppressor of LIneage defect [Source:UniProtKB/TrEMBL;Acc:Q95ZR5])

HSP 1 Score: 300.827 bits (769), Expect = 4.010e-94
Identity = 155/392 (39.54%), Postives = 233/392 (59.44%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLN-DLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGL--TCPFCRLEIKSVEDIVVK-----PYEMKESADKLTA--------PPLPPR 1419
            PPF++  + D      +++  +    D L    Y K+ L ++I++ + +IKLFK     I    S  R+KLTK+SL FSH+       F +G Y  + FR+TK +A ++W  +F  K I+ W  F+ +L   +       +   LK+TI+L  +++++ +EFDVF RL+ P+  +++ W+ L   HPGY +F+TYD+VK  L    + PG  +Y+FR SCT+ GQWAIGY+  D +I QTI QNKSL +AL +G KEG+Y YPNG    +   +L  L+       +QV+ EQY++YCEM +TFELCKIC +N+KNI++EPC HLLC  CL +W+ S G   TCPFCR EIK    +++      P E++++ +   A        P +PPR
Sbjct:   94 PPFILDILPDT---YTHLMLIFTQNNDILQDNDYLKIFLESMINKCKEIIKLFKTSA--IYNDQSEERRKLTKMSLTFSHMLFEIKALFPEGIYIEDRFRMTKKEAESFWSHHFTKKNIVPWSTFFTALEKHHGSTIGKMEAAELKATIDLSGDDFISNFEFDVFTRLFYPFKTLIKNWQTLTTAHPGYCAFLTYDEVKKRLEKLTKKPG--SYIFRLSCTRPGQWAIGYVAPDGKIYQTIPQNKSLIQALHEGHKEGFYIYPNGR---DQDINLSKLMDVPQADRVQVTSEQYELYCEMGTTFELCKICDDNEKNIKIEPCGHLLCAKCLANWQDSDGGGNTCPFCRYEIKGTNRVIIDRFKPTPVEIEKAKNVAAAEKKLISLVPDVPPR 475
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Fly
Match: Cbl (gene:FBgn0020224 transcript:FBtr0076614)

HSP 1 Score: 366.311 bits (939), Expect = 3.823e-121
Identity = 191/399 (47.87%), Postives = 270/399 (67.67%), Query Frame = 1 
Query:  199 NIDKKSLENAXXXXXXXXXXXXXXXXXXXXXPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWE-SSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            + DKK+LE   KL+DK  KL    K+NLKNSPPF++  + D    L  +    +D++  L    +F V +  ++ + ++ IKLFK+ K+++   +S  R+ LTKLSL+FSH+       F  G +  + FRITK DAA++WK NF + T++ WK F + L+  + +    + +ALK+TI+L CN++++ +EFDVF RL+QPW  +L  W+ LAV HPGY++F+TYD+VK  L  +I     G+YVFR SCT+LGQWAIGY+T + +ILQTI QNKSL +ALLDG +EG+Y YP+G   YN    L S V + T+ HI V+ EQY++YCEM STF+LCKIC+ENDK+IR+EPC HLLC PCL SW+  S G  CPFCR EIK  E IVV  ++ ++  ++
Sbjct:   38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILK--AGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQ-AYNP--DLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNR 431
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Fly
Match: Cbl (gene:FBgn0020224 transcript:FBtr0076615)

HSP 1 Score: 370.933 bits (951), Expect = 8.369e-118
Identity = 191/399 (47.87%), Postives = 270/399 (67.67%), Query Frame = 1 
Query:  199 NIDKKSLENAXXXXXXXXXXXXXXXXXXXXXPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWE-SSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            + DKK+LE   KL+DK  KL    K+NLKNSPPF++  + D    L  +    +D++  L    +F V +  ++ + ++ IKLFK+ K+++   +S  R+ LTKLSL+FSH+       F  G +  + FRITK DAA++WK NF + T++ WK F + L+  + +    + +ALK+TI+L CN++++ +EFDVF RL+QPW  +L  W+ LAV HPGY++F+TYD+VK  L  +I     G+YVFR SCT+LGQWAIGY+T + +ILQTI QNKSL +ALLDG +EG+Y YP+G   YN    L S V + T+ HI V+ EQY++YCEM STF+LCKIC+ENDK+IR+EPC HLLC PCL SW+  S G  CPFCR EIK  E IVV  ++ ++  ++
Sbjct:   38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILK--AGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQ-AYNP--DLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNR 431
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Zebrafish
Match: cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-041114-207])

HSP 1 Score: 392.119 bits (1006), Expect = 2.044e-125
Identity = 175/363 (48.21%), Postives = 251/363 (69.15%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKE 1380
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  +  ++++ I LFKD K+R+ + +S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+ +F DKTI+ WK F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  T N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E IVV P++ K+
Sbjct:   65 PPYILDLLPDTYQHLRTILSRYEGKMETLGDNEYFRVFMENLTKKTKQTISLFKDGKERMFEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNFRITKADAAEFWRRSFGDKTIVPWKVFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGR-TQNP--DLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPKD 422
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Zebrafish
Match: cblb (Cbl proto-oncogene B, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-030616-417])

HSP 1 Score: 377.481 bits (968), Expect = 1.286e-119
Identity = 173/369 (46.88%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y++  ++ +L    YFKV + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+ +F +KTI+ WK F + L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +I    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E I+V P++ +    K
Sbjct:   66 PPYILDILPDTYQHLRLILCKYEENQRLTQLSENDYFKVYIDSLMKKSKRAIRLFKEAKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQGDTFRITKADAAEFWRRSFGEKTIVPWKMFRQCLHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYINK--PGSYIFRLSCTRLGQWAIGYVTSDGNILQTIPHNKPLFQALIDGCREGFYLFPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQDSDGQGCPFCRCEIKGTEPIIVDPFDPRNEGAK 429
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Zebrafish
Match: cblb (Cbl proto-oncogene B, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-030616-417])

HSP 1 Score: 377.096 bits (967), Expect = 1.513e-119
Identity = 173/369 (46.88%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y++  ++ +L    YFKV + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+ +F +KTI+ WK F + L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +I    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E I+V P++ +    K
Sbjct:   66 PPYILDILPDTYQHLRLILCKYEENQRLTQLSENDYFKVYIDSLMKKSKRAIRLFKEAKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQGDTFRITKADAAEFWRRSFGEKTIVPWKMFRQCLHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYINK--PGSYIFRLSCTRLGQWAIGYVTSDGNILQTIPHNKPLFQALIDGCREGFYLFPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQDSDGQGCPFCRCEIKGTEPIIVDPFDPRNEGAK 429
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Zebrafish
Match: cblb (Cbl proto-oncogene B, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-030616-417])

HSP 1 Score: 377.096 bits (967), Expect = 2.031e-119
Identity = 173/369 (46.88%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y++  ++ +L    YFKV + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+ +F +KTI+ WK F + L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +I    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E I+V P++ +    K
Sbjct:   66 PPYILDILPDTYQHLRLILCKYEENQRLTQLSENDYFKVYIDSLMKKSKRAIRLFKEAKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQGDTFRITKADAAEFWRRSFGEKTIVPWKMFRQCLHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYINK--PGSYIFRLSCTRLGQWAIGYVTSDGNILQTIPHNKPLFQALIDGCREGFYLFPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQDSDGQGCPFCRCEIKGTEPIIVDPFDPRNEGAK 429
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Zebrafish
Match: cblc (Cbl proto-oncogene C, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-080220-20])

HSP 1 Score: 332.413 bits (851), Expect = 4.184e-107
Identity = 170/422 (40.28%), Postives = 264/422 (62.56%), Query Frame = 1 
Query:  127 VFSENSGKSGFMNILAINTHTSNP--NIDKKSLENAXXXXXXXXXXXXXXXXXXXXXPPFLIGTITDIQLLLNNVIFYYKD------KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPY 1368
              +   G +G   I   +   S P  + D+K LE  LK LDK  KL ++ +L LKNSPP+L   +++  + L  V   Y+       + DE     Y ++ +  ++D+++R + LFK+ K+++ + +S  R+ LTKLSL+FSH+       F  G +  + +R+TK +A  +W+  F  K I+ W  F + L   +   +  + +ALKST++L CN++++++EFD+F RL+QPW+ ++  W  LAV HPGYM+F+TYD VK  L ++     PG+Y+FR SCT++GQWAIG++T D  I+QTI QN  L +AL+ G +EG Y YP+G         L S VH   +  ++V+ EQY++YCE+ STF+LCKIC+E DK+ R++PC HLLC+PCL  W+ S G TCP+CR +I+  E I+++PY
Sbjct:    3 AMARRPGTAGRSQISDTSETPSQPPTSADRKLLEKVLKRLDKLHKLSVDPRLALKNSPPYLPELLSETAIHLTEVWAPYRGSAMAVPRWDE---GDYMRIHIRHLLDKTDRAVLLFKEGKEKMFEETSNYRRNLTKLSLLFSHMLNELRTIFPGGRFQGDTYRVTKTEAKEFWRKTFGHKCIVQWNVFKQQLKRVHYFEEGMEAMALKSTVDLTCNDHISIFEFDIFTRLFQPWSTLIRNWNHLAVTHPGYMAFLTYDQVKARLEHYRHR--PGSYIFRLSCTQMGQWAIGHVTSDGSIVQTIPQNTPLYQALIQGFREGCYLYPDGRDVNPDLSSLCSPVH---KGRVKVTEEQYELYCEIGSTFQLCKICTERDKDTRIQPCGHLLCQPCLTGWQKSDGHTCPYCRCDIRGTESILIEPY 416
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Xenopus
Match: cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:594900])

HSP 1 Score: 379.022 bits (972), Expect = 8.468e-122
Identity = 187/401 (46.63%), Postives = 272/401 (67.83%), Query Frame = 1 
Query:  187 TSNPN-IDKKSLENAXXXXXXXXXXXXXXXXXXXXXPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            T+ P  +D+K++E   KL+DK  +L  N +L LKNSPP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  ++FRITK DAA +W+  F +KTI+ WK F  +L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ +   
Sbjct:   53 TAQPGAVDRKTVEKCWKLMDKVVRLCQNQRLALKNSPPYILDLLPDTYQHLRTIMSRYEGKMEILGENEYFRVFMENLLKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGQFQGDSFRITKADAAEFWRKAFGEKTIVPWKIFRLALHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGFREGFYLFPDGR---NQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGGG 448
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Xenopus
Match: cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:594900])

HSP 1 Score: 380.563 bits (976), Expect = 1.310e-121
Identity = 171/365 (46.85%), Postives = 248/365 (67.95%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  ++FRITK DAA +W+  F +KTI+ WK F  +L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ +   
Sbjct:   89 PPYILDLLPDTYQHLRTIMSRYEGKMEILGENEYFRVFMENLLKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGQFQGDSFRITKADAAEFWRKAFGEKTIVPWKIFRLALHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGFREGFYLFPDGR---NQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGGG 448
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Xenopus
Match: cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:594900])

HSP 1 Score: 380.948 bits (977), Expect = 4.346e-121
Identity = 171/365 (46.85%), Postives = 248/365 (67.95%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  ++FRITK DAA +W+  F +KTI+ WK F  +L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ +   
Sbjct:  129 PPYILDLLPDTYQHLRTIMSRYEGKMEILGENEYFRVFMENLLKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGQFQGDSFRITKADAAEFWRKAFGEKTIVPWKIFRLALHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGGG 488
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Xenopus
Match: cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:594900])

HSP 1 Score: 381.333 bits (978), Expect = 9.166e-121
Identity = 171/365 (46.85%), Postives = 248/365 (67.95%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  ++FRITK DAA +W+  F +KTI+ WK F  +L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ +   
Sbjct:  129 PPYILDLLPDTYQHLRTIMSRYEGKMEILGENEYFRVFMENLLKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGQFQGDSFRITKADAAEFWRKAFGEKTIVPWKIFRLALHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGGG 488
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Xenopus
Match: cblb (Cbl proto-oncogene B, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:448509])

HSP 1 Score: 375.555 bits (963), Expect = 1.570e-120
Identity = 174/365 (47.67%), Postives = 250/365 (68.49%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKE 1380
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F ++TI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +  +  PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ ++
Sbjct:   82 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQERRNLTKLSLIFSHMLAEIKAIFPSGQFQGDNFRITKADAAEFWRKFFGERTIVPWKIFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWTSILRNWNFLAVTHPGYMAFLTYDEVKARLQKY--STKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTDLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESDGQGCPFCRCEIKGTEPIVVDPFDPRD 441
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Mouse
Match: Cbl (Casitas B-lineage lymphoma [Source:MGI Symbol;Acc:MGI:88279])

HSP 1 Score: 390.578 bits (1002), Expect = 7.277e-125
Identity = 174/368 (47.28%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  V+  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   79 PPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 441
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Mouse
Match: Cbl (Casitas B-lineage lymphoma [Source:MGI Symbol;Acc:MGI:88279])

HSP 1 Score: 390.193 bits (1001), Expect = 1.281e-124
Identity = 174/368 (47.28%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  V+  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   79 PPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 441
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Mouse
Match: Cbl (Casitas B-lineage lymphoma [Source:MGI Symbol;Acc:MGI:88279])

HSP 1 Score: 388.652 bits (997), Expect = 1.760e-124
Identity = 174/368 (47.28%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  V+  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   79 PPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 441
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Mouse
Match: Cblb (Casitas B-lineage lymphoma b [Source:MGI Symbol;Acc:MGI:2146430])

HSP 1 Score: 379.407 bits (973), Expect = 3.278e-120
Identity = 174/369 (47.15%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +     PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ ++   +
Sbjct:   71 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSR 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Mouse
Match: Cblb (Casitas B-lineage lymphoma b [Source:MGI Symbol;Acc:MGI:2146430])

HSP 1 Score: 379.407 bits (973), Expect = 3.278e-120
Identity = 174/369 (47.15%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +     PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ ++   +
Sbjct:   71 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSR 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. UniProt/SwissProt
Match: sp|P22682|CBL_MOUSE (E3 ubiquitin-protein ligase CBL OS=Mus musculus OX=10090 GN=Cbl PE=1 SV=3)

HSP 1 Score: 390.193 bits (1001), Expect = 8.957e-124
Identity = 174/368 (47.28%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  V+  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   79 PPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 441
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. UniProt/SwissProt
Match: sp|P22681|CBL_HUMAN (E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2)

HSP 1 Score: 387.882 bits (995), Expect = 5.414e-123
Identity = 173/368 (47.01%), Postives = 251/368 (68.21%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F +KTI+ WK+F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G    N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL SW+ S G  CPFCR EIK  E IVV P++ + S   L
Sbjct:   81 PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDG---RNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLL 443
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. UniProt/SwissProt
Match: sp|Q8K4S7|CBLB_RAT (E3 ubiquitin-protein ligase CBL-B OS=Rattus norvegicus OX=10116 GN=Cblb PE=1 SV=1)

HSP 1 Score: 379.793 bits (974), Expect = 1.671e-119
Identity = 174/369 (47.15%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +     PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ ++   +
Sbjct:   71 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSR 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. UniProt/SwissProt
Match: sp|Q3TTA7|CBLB_MOUSE (E3 ubiquitin-protein ligase CBL-B OS=Mus musculus OX=10090 GN=Cblb PE=1 SV=3)

HSP 1 Score: 379.793 bits (974), Expect = 3.459e-119
Identity = 174/369 (47.15%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +     PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ ++   +
Sbjct:   71 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSR 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. UniProt/SwissProt
Match: sp|Q13191|CBLB_HUMAN (E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens OX=9606 GN=CBLB PE=1 SV=2)

HSP 1 Score: 379.407 bits (973), Expect = 6.505e-119
Identity = 174/369 (47.15%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y D  K+ +L    YFK+ + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F + L   ++++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +     PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y YP+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ ++   +
Sbjct:   71 PPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSR 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. TrEMBL
Match: A0A448WE97 (Uncharacterized protein OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS3034 PE=4 SV=1)

HSP 1 Score: 451.44 bits (1160), Expect = 2.052e-147
Identity = 232/445 (52.13%), Postives = 312/445 (70.11%), Query Frame = 1 
Query:   79 FNNVPSN--KNVINFFQNVFSENSGKSGFMNILAINTHTSNPN------IDKKSLENAXXXXXXXXXXXXXXXXXXXXXPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWES-SSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            FN++ SN   N    F  V       SG  +++  ++  + PN      I+KK++ +A K++++  +L L   L LKNSPP+++  + DI   L  ++  Y +  + L  + YF++ + T+ D+ +  +KLFK+ KDRI    S  R +LTKLSLIFSH+ K  +  F   +Y  E+FRITK DAA WW  +F  + I+ W  F  +L L++ ++D SQ +AL+STI+L CN +V+++EFDVFVRL+QPWNNILETWKALAVLHPGYM+FMTYD+VK VL  +  +PG G+YVFR+SCTKLGQWAIGYITED QILQTIIQNKSLARALLDGE E +Y YPNG  + ++   LY LVHNL + H+QVS EQY++YCEM STFELCKIC+ENDK++RLEPC HLLC+ CL++ +   +G  CPFCRLEIK VEDI++ PY+    A
Sbjct:   19 FNDIDSNMHSNGRRIFSRVHGLVETLSG--SLITASSTCTKPNMAAYLSIEKKTINSAHKMIERVVQLCLQPALELKNSPPYILDNLPDIYNRLREIVNRYSENYEVLCKLDYFRIFISTLCDKCKMTVKLFKESKDRIFDKKSQCRHRLTKLSLIFSHLLKDLDALFPSNYYSPESFRITKPDAAKWWNSSFEGRAIVPWHIFKTALFLSFGVSDPSQLMALQSTIDLTCNEHVSIFEFDVFVRLFQPWNNILETWKALAVLHPGYMAFMTYDEVKAVLSRYKHHPGSGSYVFRASCTKLGQWAIGYITEDLQILQTIIQNKSLARALLDGEYENFYLYPNGKQSDSSI--LYQLVHNLPEVHLQVSQEQYQIYCEMGSTFELCKICAENDKDVRLEPCGHLLCKSCLINCQYLVNGQMCPFCRLEIKGVEDIIIDPYKPSRMA 459
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. TrEMBL
Match: A0A504YUY0 (E3 ubiquitin protein ligase CBL OS=Fasciola gigantica OX=46835 GN=FGIG_10239 PE=4 SV=1)

HSP 1 Score: 439.113 bits (1128), Expect = 6.234e-142
Identity = 203/361 (56.23%), Postives = 266/361 (73.68%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSS-GLTCPFCRLEIKSVEDIVVKPYE 1371
            PP+L+ T+ DI   L ++I  Y D  + L  + YF+V + ++ D+ +R +KLFKD  D+I  V S +R +L KLSLIFSH+ K     F +  +C E FRITK DAA WW  NF    ++ W  F  +L  T++++   Q  AL++TI+L CN YV+++EFDVF+RL+QPWNNILETWKALAVLHPGYM+FMTYD+VK  L  +  +PGPGTYVFR SCTKLGQWAIGY+TED +ILQTIIQNKSLA+ALLDGE+EG+Y YPNG  + ++   L+ LVH L Q  +QV+ EQY+VYCEM STFELCKIC EN+K+++LEPC HL+C+ CL++  S+    TCPFCRLEIK +ED++V PY 
Sbjct:   76 PPYLLDTMPDIYEKLRSIISSYSDDYETLSQMKYFRVFVHSVTDKCKRTVKLFKDAGDKIFDVHSHSRFRLVKLSLIFSHLLKDLEALFPQNIFCAE-FRITKPDAARWWSSNFGASVVVPWSAFQSALLQTFRVDSNDQLGALRNTIDLTCNEYVSIFEFDVFIRLFQPWNNILETWKALAVLHPGYMAFMTYDEVKARLKQYRAHPGPGTYVFRLSCTKLGQWAIGYVTEDLKILQTIIQNKSLAQALLDGEREGFYLYPNGKSSPSSL--LHQLVHELPQVRLQVTQEQYQVYCEMGSTFELCKICDENNKDVQLEPCGHLICKHCLLNCRSAGCSQTCPFCRLEIKGIEDVIVDPYR 433
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. TrEMBL
Match: A0A3P7NGE8 (Uncharacterized protein (Fragment) OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS16965 PE=4 SV=1)

HSP 1 Score: 429.098 bits (1102), Expect = 6.803e-142
Identity = 200/366 (54.64%), Postives = 275/366 (75.14%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWE-SSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+L+  + D+   L  +I  Y   +DEL    YF+V L  +I++ +   KLFK+ K+ +    S  R+KLTK SL+FSH+ K     +    +  ENFRITK +AA WW+ +F+   I+ W+ F  +LS ++ ++  S+  AL++TI+L CN+YV+++EFDVFVRL+QPWNN++ETWKALA+LH GYM+FMTYD+VK VL  F  +PGPG+YV+R SCTKLGQWAIGYIT+D++ILQTIIQNKSLA+AL+DGE+EG+Y YPNG+ + ++   L SLV NL QTH++VS EQY++YC+M STFELCKIC+EN+KN++LEPC HLLC+ CL+S + S +G TCPFCRLEIKS+E+I++ PY   E A
Sbjct:   62 PPYLLEILPDMYEKLKAIITAYSSTLDELFNTLYFQVFLNNLINKCKSTSKLFKEAKELMYDEQSEYRRKLTKNSLVFSHILKDLEALYPNNHFSPENFRITKKEAAEWWRSHFDYSPIVPWQLFQAALSESFHIDCRSEFRALQNTIDLTCNDYVSVFEFDVFVRLFQPWNNVIETWKALAILHAGYMAFMTYDEVKAVLKRFRHHPGPGSYVYRLSCTKLGQWAIGYITQDRRILQTIIQNKSLAQALIDGEREGFYLYPNGTPSQSSI--LSSLVENLPQTHLRVSQEQYQLYCKMGSTFELCKICTENNKNVQLEPCGHLLCKSCLISCQGSGTGQTCPFCRLEIKSIEEIILDPYLPDEDA 425
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. TrEMBL
Match: A0A2H1BWT0 (CBL proto-oncogene, SH2-like domain protein OS=Fasciola hepatica OX=6192 GN=D915_008908 PE=4 SV=1)

HSP 1 Score: 437.958 bits (1125), Expect = 1.827e-141
Identity = 203/361 (56.23%), Postives = 266/361 (73.68%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSS-GLTCPFCRLEIKSVEDIVVKPYE 1371
            PP+L+ T+ DI   L ++I  Y D  + L  + YF+V + ++ D+ +R +KLFKD  D+I  V S +R +L KLSLIFSH+ K     F +  +C E FRITK DAA WW  NF    ++ W  F  +L  T++++   Q  AL++TI+L CN YV+++EFDVF+RL+QPWNNILETWKALAVLHPGYM+FMTYD+VK  L  +  +PGPGTYVFR SCTKLGQWAIGY+TED +ILQTIIQNKSLA+ALLDGE+EG+Y YPNG  + ++   L+ LVH L Q  +QV+ EQY+VYCEM STFELCKIC EN+K+++LEPC HL+C+ CL++  S+    TCPFCRLEIK +ED++V PY 
Sbjct:   76 PPYLLDTMPDIYEKLRSIINRYSDDYETLSQMKYFRVFVHSVTDKCKRTVKLFKDAGDKIFDVHSHSRFRLVKLSLIFSHLLKDLEALFPQNTFCAE-FRITKPDAARWWSSNFGSSVVVPWSAFQSALLETFRVDSNDQLGALRNTIDLTCNEYVSIFEFDVFIRLFQPWNNILETWKALAVLHPGYMAFMTYDEVKARLKQYRAHPGPGTYVFRLSCTKLGQWAIGYVTEDLKILQTIIQNKSLAQALLDGEREGFYLYPNGKSSPSSL--LHQLVHELPQVRLQVTQEQYQVYCEMGSTFELCKICDENNKDVQLEPCGHLICKHCLLNCRSAGCSQTCPFCRLEIKGIEDVIVDPYR 433
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. TrEMBL
Match: A0A4Z2D9L0 (E3 ubiquitin-protein ligase CBL OS=Schistosoma japonicum OX=6182 GN=EWB00_003123 PE=4 SV=1)

HSP 1 Score: 434.106 bits (1115), Expect = 6.967e-141
Identity = 204/369 (55.28%), Postives = 274/369 (74.25%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESS-SGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            PP+++ TI DI   L  +   Y++  D L  I YF++ +LT+I++ ++ I LFK+ K++I  + S AR +L KLSL++SH+       F +  + V +FRITK +AA+WW  NF D  I+SW+ F  SL  T++++  +Q +AL++TI++ CNNYV+++EFDVF RL+QPWNNILETWKALA+LHPGYM+FMTYD VK VL  +   PGPGTY+FR SCTKLGQWAIGYIT + +ILQTIIQNKSL +AL+DGE+EG+Y YPNG  +      LY L H+L Q H+QV+ EQY+VYCEM STFELCKIC EN+K+ RLEPC HL+C+ CL++ +S+ +GLTCPFCRLEIK  EDI+V PY+    + KL
Sbjct:   32 PPYILDTIPDIYEKLQGITAKYEENYDILSEIDYFQIYILTLIEKCKQTINLFKNSKEKIFDIDSDARFRLVKLSLVYSHLLNDLEALFPQNTF-VPSFRITKPNAAHWWVTNFGDSVIVSWQLFKNSLIQTFRIDSDTQLLALQTTIDITCNNYVSIFEFDVFTRLFQPWNNILETWKALAILHPGYMAFMTYDQVKAVLKRYCSYPGPGTYIFRLSCTKLGQWAIGYITRELKILQTIIQNKSLTQALVDGEREGFYLYPNGKPSPTTL--LYHLTHDLLQVHLQVTKEQYQVYCEMGSTFELCKICDENNKDTRLEPCGHLICKNCLLNCQSTVNGLTCPFCRLEIKDTEDIIVDPYKPSGDSGKL 397
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Cavefish
Match: cbl (Cbl proto-oncogene [Source:NCBI gene;Acc:103032411])

HSP 1 Score: 388.267 bits (996), Expect = 1.059e-124
Identity = 174/365 (47.67%), Postives = 254/365 (69.59%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+ +F DKTI+ WK F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  T N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E IVV P++ K+++
Sbjct:   65 PPYILDLLPDTYQHLRTILSRYEGKMETLGDNEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPSGLFQGDNFRITKADAAEFWRKSFGDKTIVQWKIFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGR-TQNP--DLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPKDNS 424
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Cavefish
Match: cbl (Cbl proto-oncogene [Source:NCBI gene;Acc:103032411])

HSP 1 Score: 389.808 bits (1000), Expect = 1.399e-124
Identity = 174/365 (47.67%), Postives = 254/365 (69.59%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y+ K++ L    YF+V +  ++ ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+ +F DKTI+ WK F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  T N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E IVV P++ K+++
Sbjct:   65 PPYILDLLPDTYQHLRTILSRYEGKMETLGDNEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPSGLFQGDNFRITKADAAEFWRKSFGDKTIVQWKIFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGR-TQNP--DLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPKDNS 424
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Cavefish
Match: cblb (Cbl proto-oncogene B [Source:NCBI gene;Acc:103034711])

HSP 1 Score: 374.015 bits (959), Expect = 5.253e-118
Identity = 173/369 (46.88%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y++  K+ +L    YFKV + +++ +S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA +W+  F++KTI+ WK F + L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L  +I    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  +YN    L  L       HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK  E I+V P++ +    K
Sbjct:   71 PPYILDILPDTYQHLRMILCKYEENQKLVQLSENDYFKVYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPDGQFQGDTFRITKADAAEFWRRFFSEKTIVPWKVFRQCLHEMHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYINK--PGSYIFRLSCTRLGQWAIGYVTSDGNILQTIPHNKPLFQALIDGCREGFYLFPDGR-SYNP--DLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTERIIVDPFDPRNEGAK 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Cavefish
Match: cblc (E3 ubiquitin-protein ligase CBL-like [Source:NCBI gene;Acc:103042889])

HSP 1 Score: 328.561 bits (841), Expect = 1.166e-104
Identity = 150/365 (41.10%), Postives = 232/365 (63.56%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD------KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPY 1368
            PP+L   +++  +LL  V   Y+       + DE     + K+ +  ++D++ R I LFK+ KD++ +  S  R+ LTKLSL+FSH+       F  G +  + +++TK +A  +WK  F  + I+ W  F   L   +   +  + +ALKST++L CN++++++EFD+F RL+QPW+ +L  W  LAV HPGYM+F+TYD V+  L +      PG+Y+FR SCT++GQWA+G++T D  I+QTI +N  L +AL+ G +EG Y YP+G    +    L SL     +  ++V+ EQY++YCE+ STF+LCKIC+E DK+ R++PC HLLCRPCL  W+ S G TCP+CR +I+  E I+V+PY
Sbjct:   59 PPYLPDLVSETVILLTEVWDPYRGPAPAVPRGDE---ADFLKIHVRHLLDKTNRAILLFKEGKDKMFEERSSYRRNLTKLSLLFSHMLWELRAMFPDGRFQGDIYKLTKTEAQEFWKKTFGYRCIVQWSQFKHQLKRVHGFEEGMEAMALKSTVDLTCNDHISVFEFDIFTRLFQPWSTLLRNWNQLAVTHPGYMAFLTYDQVRARLEHHRHR--PGSYIFRLSCTRMGQWAVGHVTFDGSIVQTIPENTPLFQALIQGFREGCYLYPDGR---DVNPDLTSLCMAPQKGRVKVTEEQYELYCEIGSTFQLCKICTERDKDTRIQPCGHLLCRPCLTGWQKSDGHTCPYCRCDIRGTESILVEPY 415
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Cavefish
Match: cblc (E3 ubiquitin-protein ligase CBL-like [Source:NCBI gene;Acc:103042889])

HSP 1 Score: 328.561 bits (841), Expect = 1.166e-104
Identity = 150/365 (41.10%), Postives = 232/365 (63.56%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD------KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPY 1368
            PP+L   +++  +LL  V   Y+       + DE     + K+ +  ++D++ R I LFK+ KD++ +  S  R+ LTKLSL+FSH+       F  G +  + +++TK +A  +WK  F  + I+ W  F   L   +   +  + +ALKST++L CN++++++EFD+F RL+QPW+ +L  W  LAV HPGYM+F+TYD V+  L +      PG+Y+FR SCT++GQWA+G++T D  I+QTI +N  L +AL+ G +EG Y YP+G    +    L SL     +  ++V+ EQY++YCE+ STF+LCKIC+E DK+ R++PC HLLCRPCL  W+ S G TCP+CR +I+  E I+V+PY
Sbjct:   59 PPYLPDLVSETVILLTEVWDPYRGPAPAVPRGDE---ADFLKIHVRHLLDKTNRAILLFKEGKDKMFEERSSYRRNLTKLSLLFSHMLWELRAMFPDGRFQGDIYKLTKTEAQEFWKKTFGYRCIVQWSQFKHQLKRVHGFEEGMEAMALKSTVDLTCNDHISVFEFDIFTRLFQPWSTLLRNWNQLAVTHPGYMAFLTYDQVRARLEHHRHR--PGSYIFRLSCTRMGQWAVGHVTFDGSIVQTIPENTPLFQALIQGFREGCYLYPDGR---DVNPDLTSLCMAPQKGRVKVTEEQYELYCEIGSTFQLCKICTERDKDTRIQPCGHLLCRPCLTGWQKSDGHTCPYCRCDIRGTESILVEPY 415
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Sea Lamprey
Match: cblc (Cbl proto-oncogene C, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-080220-20])

HSP 1 Score: 193.741 bits (491), Expect = 1.349e-57
Identity = 88/213 (41.31%), Postives = 138/213 (64.79%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTY 930
            PP+++  + D    L  V+  + D++  L    +F+V +  ++ +S++ + LFK+ K+R+    S  R+ LTKLSLIFSH+       F  G Y  ++FRITK DAA++W+  F D+TI+SWK F + L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W  LAV HPGYM+F+TYD+VK  L  +I  PG   Y
Sbjct:   70 PPYMLDILPDTYQHLRLVLARHDDRMAALGDNEFFRVFIDNLLSKSKQAVNLFKEGKERMHDEHSHCRRNLTKLSLIFSHMLTELKAVFPNGSYQGDSFRITKADAADFWRRAFGDRTIVSWKAFRQCLHEVHPISSGLEAMALKSTIDLTCNDYISIFEFDIFTRLFQPWSSLLRNWNVLAVTHPGYMAFLTYDEVKARLQKYISKPGSYIY 282
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Nematostella
Match: EDO44234 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWB7])

HSP 1 Score: 47.7506 bits (112), Expect = 9.658e-6
Identity = 25/69 (36.23%), Postives = 36/69 (52.17%), Query Frame = 1 
Query: 1204 LCKICSENDKNIRLEPCQHL-LCRPC----LVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKL 1395
            LC IC+E  K I + PC+H+ LC  C    L  W   +   CP CR  I+S+ + +V     KE+  K+
Sbjct:  455 LCVICAEQPKQILIMPCRHMCLCSVCADTLLTHWNRRA---CPLCRCRIRSLIEGIVGKQNWKEAGKKI 520
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Medaka
Match: ENSORLT00000018206.2 (E3 ubiquitin-protein ligase CBL [Source:NCBI gene;Acc:101163758])

HSP 1 Score: 387.497 bits (994), Expect = 2.907e-124
Identity = 172/365 (47.12%), Postives = 250/365 (68.49%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y+ KI+ L    YF+V +  + +++++ + LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+ +F DKTI+ W+ F ++L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G         L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC+HL+C  CL +W+ S G  CPFCR EIK  E IVV P+  K S 
Sbjct:   64 PPYILDLLPDTYQHLRTILSRYEGKIEILGENEYFRVFIDNLTNKTKQTMSLFKEAKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNFRITKADAAEFWRRSFGDKTIVPWRTFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQRFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGYREGFYLFPDGRAQ---NPDLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCRHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFHPKASG 423
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Medaka
Match: cbl (Cbl proto-oncogene [Source:NCBI gene;Acc:101170289])

HSP 1 Score: 384.03 bits (985), Expect = 4.860e-122
Identity = 175/367 (47.68%), Postives = 251/367 (68.39%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSS--GLTCPFCRLEIKSVEDIVVKPYEMKESA 1386
            PP+++  + D    L  ++  Y  K++ L    YF+V +  +  ++++ I LFK+ K+R+ + +S  R+ LTKLSLIFSH+       F  G +  +NFRITK DAA +W+  F DKTI+ WK F +SL   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW+++L  W +LAV HPGYM+F+TYD+VK  L  FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  T N    L  L     Q HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S   G  CPFCR EIK  E IVV P++ K+++
Sbjct:   65 PPYILDLLPDTYQHLRTILSRYDGKMETLGDNEYFRVFVENLTKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNFRITKADAAEFWRRAFGDKTIVPWKVFRQSLHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGR-TQNP--DLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGTGCPFCRCEIKGTEPIVVDPFDPKDNS 426
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Medaka
Match: cblb (Cbl proto-oncogene B [Source:NCBI gene;Acc:101157475])

HSP 1 Score: 372.474 bits (955), Expect = 5.780e-118
Identity = 170/369 (46.07%), Postives = 250/369 (67.75%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD--KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADK 1392
            PP+++  + D    L  ++  Y++  ++ +L    YFK+ +  ++++S+R I+LFK+ K+R+ +  S  R+ LTKLSLIFSH+       F  G +  + FRITK DAA++W+  F +KT++ W+ F + L   + ++   + +ALKSTI+L CN+Y++++EFD+F RL+QPW +IL  W  LAV HPGYM+F+TYD+VK  L+ FI    PG+Y+FR SCT+LGQWAIGY+T D  ILQTI  NK L +AL+DG +EG+Y +P+G  +YN    L  L   L   HI+V+ EQY++YCEM STF+LCKIC+ENDK++++EPC HL+C  CL +W+ S G  CPFCR EIK    I V P++ +    K
Sbjct:   71 PPYILDILPDAYQHLRLILGKYEENQRLTQLSENEYFKIYIDGLMNKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKALFPGGQFQGDTFRITKADAADFWRTYFGEKTVVPWRVFRQCLHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLLKFINK--PGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGFREGFYLFPDGR-SYNP--DLTDLCDPLPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTLCLTAWQESDGQGCPFCRCEIKGTAPITVDPFDPRNEGAK 434
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Medaka
Match: cblc (E3 ubiquitin-protein ligase CBL [Source:NCBI gene;Acc:101158476])

HSP 1 Score: 323.168 bits (827), Expect = 7.160e-103
Identity = 149/375 (39.73%), Postives = 238/375 (63.47%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD---------KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESAD 1389
            PP+L   + +   LL+ V   Y           + DE    TY  V +  ++D++E+ + LFKD +++I   +S  R+ LTKLSL+FSH+       F  G +  + +++TK  A  +W+ +F +K I+ W +F + L   +   +  + +ALKSTI+L CN+Y++++EFD+F RL+QPW++++  W  +AV HPGYM+F+TYD V   L +++    PG+Y+FR SCT++GQWA+G++T +  I+QT+  +  L +AL+ G KEG Y YP+G    +    L  L     +  +QV+ EQY +YCE+ STFELCKIC+E DK+ R++PC HLLC+ CL  W+ S G TCP+CR +IK  E ++++P+ +K+S+D
Sbjct:   53 PPYLPDLVRETLTLLHQVWEPYLGYSSAGGQFPRGDE---ATYLGVHVRNLLDKTEKAMLLFKDGREKIFDETSSCRRNLTKLSLLFSHMLWELKAMFPGGHFQGDTYKLTKSKAEEFWRRSFGNKCIVPWNHFKQQLRTVHPFEERMEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLIRNWNHMAVTHPGYMAFLTYDQVVERLEHYLHK--PGSYIFRLSCTRMGQWAVGHVTAEGDIIQTLPGDTPLYQALIQGFKEGCYLYPDGR---DVNPELTCLCETAQKQTVQVTEEQYGLYCEIGSTFELCKICAEKDKDTRIKPCGHLLCKSCLFGWQKSVGNTCPYCRCDIKGTESVLIEPF-LKDSSD 418
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Medaka
Match: cblc (E3 ubiquitin-protein ligase CBL [Source:NCBI gene;Acc:101158476])

HSP 1 Score: 323.168 bits (827), Expect = 7.160e-103
Identity = 149/375 (39.73%), Postives = 238/375 (63.47%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKD---------KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESAD 1389
            PP+L   + +   LL+ V   Y           + DE    TY  V +  ++D++E+ + LFKD +++I   +S  R+ LTKLSL+FSH+       F  G +  + +++TK  A  +W+ +F +K I+ W +F + L   +   +  + +ALKSTI+L CN+Y++++EFD+F RL+QPW++++  W  +AV HPGYM+F+TYD V   L +++    PG+Y+FR SCT++GQWA+G++T +  I+QT+  +  L +AL+ G KEG Y YP+G    +    L  L     +  +QV+ EQY +YCE+ STFELCKIC+E DK+ R++PC HLLC+ CL  W+ S G TCP+CR +IK  E ++++P+ +K+S+D
Sbjct:   53 PPYLPDLVRETLTLLHQVWEPYLGYSSAGGQFPRGDE---ATYLGVHVRNLLDKTEKAMLLFKDGREKIFDETSSCRRNLTKLSLLFSHMLWELKAMFPGGHFQGDTYKLTKSKAEEFWRRSFGNKCIVPWNHFKQQLRTVHPFEERMEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLIRNWNHMAVTHPGYMAFLTYDQVVERLEHYLHK--PGSYIFRLSCTRMGQWAVGHVTAEGDIIQTLPGDTPLYQALIQGFKEGCYLYPDGR---DVNPELTCLCETAQKQTVQVTEEQYGLYCEIGSTFELCKICAEKDKDTRIKPCGHLLCKSCLFGWQKSVGNTCPYCRCDIKGTESVLIEPF-LKDSSD 418
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Planmine SMEST
Match: SMESG000056433.1 (SMESG000056433.1)

HSP 1 Score: 1084.32 bits (2803), Expect = 0.000e+0
Identity = 562/564 (99.65%), Postives = 563/564 (99.82%), Query Frame = 1 
Query:   64 MADVSFNNVPSNKNVINFFQNVFSENSGKSGFMNILAINTHTSNPNIDKKSLENAXXXXXXXXXXXXXXXXXXXXXPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKLTAPPLPPRPIMXXXXXXXXXXXXLMATSNIELNYAVLDFPDYPIASKATQVNFMPTSSHSNGCQLQDIDSQHDLEKNLKTLIENEKIDMKVAKLILKITDNDINKSRTILKYFKIKDDIF 1755
            MADVSFNNVPSNKNVINFFQNVFSENSGKSGFMNILAINTHTSNPNIDKKSLENALKLLDKCKKLYLNSKLNLKNSPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKLTAPPLPPRPIMSTSTISTNSDNDLMATSNIELNYAVLDFPDYPIASKATQVNFMPTSSH+NGCQLQDID QHDLEKNLKTLIENEKIDMKVAKLILKITDNDINKSRTILKYFKIKDDIF
Sbjct:    1 MADVSFNNVPSNKNVINFFQNVFSENSGKSGFMNILAINTHTSNPNIDKKSLENALKLLDKCKKLYLNSKLNLKNSPPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKLTAPPLPPRPIMSTSTISTNSDNDLMATSNIELNYAVLDFPDYPIASKATQVNFMPTSSHTNGCQLQDIDCQHDLEKNLKTLIENEKIDMKVAKLILKITDNDINKSRTILKYFKIKDDIF 564
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Planmine SMEST
Match: SMESG000072524.1 (SMESG000072524.1)

HSP 1 Score: 342.813 bits (878), Expect = 3.766e-110
Identity = 200/528 (37.88%), Postives = 296/528 (56.06%), Query Frame = 1 
Query:  292 PPFLIGTITDIQLLLNNVIFYYKDKIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFND-KTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQ---VSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESS-SGLTCPFCRLEIKSVEDIVVKPYEMKESADK---LTAPPLPPRPIMXXXXXXXXXXXXLMATSNIELNYAVLDF----------------------------PDYPIASKATQVNFMPTSSHSNGCQLQDID-----SQHDLEKNLKTLIENEKIDMKVA------KLILKITDNDINKSRTILKYF 1734
            PP+L   + +    + +++  Y++K++EL  I +F+V + T+I Q + ++++ +       + S P R+KL  +S++ SH++      F    Y  E FRITK DAA+WW   F    T++ W +F+   S    ++++SQ  AL+ TIN+  N +V++++FDVFVRL+QPWNNILE+WK + + HPG MS++TY+ V  +L +F   PGPG+YVFR SCTK GQWAIGYI    +I QTI+ NKSLA AL +GE+ G YKYPNG I  N++      +HNL  + +Q   VS E+++ Y  +DS+FELCKICS+N+KNI+LEPC HLLC  CL  W+ S    +CPFCRLEIK +E I + PY+ K    +   +  P +PPR +       ++    L   +  ++NYA LD+                            PD       +++   PTSS  N C   +       S H L        +N    M +       K +LKIT ND+  S+ ILK+F
Sbjct:   72 PPYLPCILRNFSHKIMDILKCYENKLNELSKINFFRVSIWTLIKQCKDILRVIRRVNFSFDEFSEP-RQKLIDISILLSHLFHAVVALFPNSCYAPEAFRITKSDAADWWNSQFGALTTVVKWNDFFHFFSKINYISEVSQIAALRKTINVTGNGFVSIFDFDVFVRLFQPWNNILESWKVIVLEHPGCMSYITYEQVVQLLKSFRCYPGPGSYVFRFSCTKPGQWAIGYIDLSGKIYQTIVHNKSLAIALYEGEQAGIYKYPNGKIYDNSF------LHNLVSSPLQNIIVSLEEHEAYSLIDSSFELCKICSQNNKNIKLEPCGHLLCNFCLSRWQKSFRCQSCPFCRLEIKGIEKISLIPYDSKNENTQNKSIDCPLVPPRQMSFLQKQISDEKCSLSNDNGNKVNYAQLDWVSGNDSGSLINSYETENIESTSKTNDTKPDSSFI--ISEIQSAPTSSQ-NKCPNDNSTNYESCSSHYLNLRNSNFSDNHNTLMHITNNSEAMKKLLKITGNDVTMSKEILKHF 589
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Planmine SMEST
Match: SMESG000006795.1 (SMESG000006795.1)

HSP 1 Score: 157.147 bits (396), Expect = 9.778e-41
Identity = 104/330 (31.52%), Postives = 146/330 (44.24%), Query Frame = 1 
Query:  367 IDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKLSLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKNFYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNILETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQWAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHLYSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHLLCRPCLVSWESSSGLTCPFCRLEIKSVEDIV 1356
            +D L  I Y   +   +I+      K  +D    I       RK      + F  +Y     +F  G Y   N +I+K  A  WW+  F D   +       SLS T                            FD+F RLY PW  ILE W+ +   HP Y+ F TY D K  L  ++  PG  TYVFR SC  LG W IGY+   K++ Q  +   +L  AL++G K   Y YPNG    +    L +L  N  +  I V++E  ++Y E    F+ CKIC E++K+++LE C H +C+ C           CPFC  +I+S   IV
Sbjct:   51 LDYLNNIPYILQLKNNMINLYNSFAKFVQDNGPLIGTKDDHMRKTFFTKVVHFQFLYFEIQAYFPNGIYSPHNVKISKNPARMWWEKKFGDNIFVDLDVRKYSLSKT----------------------------FDLFTRLYSPWERILEVWRVIYS-HPAYLHFSTYGDTKDTLSRYLNEPG--TYVFRISCKDLGFWTIGYVKSSKEMGQVKVDKSNLIEALVEGNKRNMYLYPNGE---SCNPDLSTL--NEFRKEIVVNNEDLQLY-ECFDDFKECKICRESEKDLQLESCGHQICQSCYKLLRKYDKRNCPFCNQKIQSTTKIV 343
[Close]
BLAST of E3 ubiquitin-protein ligase CBL vs. Planmine SMEST
Match: SMESG000060298.1 (SMESG000060298.1)

HSP 1 Score: 48.1358 bits (113), Expect = 4.984e-6
Identity = 27/74 (36.49%), Postives = 34/74 (45.95%), Query Frame = 1 
Query: 1207 CKICSENDKNIRLEPCQHLLCRPCLVSW--ESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKLTAPPLPPRP 1422
            C IC E  K+  +  C HL C PCL  W    SS  TCP C+  I    D V+  Y    +  +     +PPRP
Sbjct:   33 CNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAIS--RDKVIPLYGRDSTDQRDPRDKIPPRP 104
The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CBL4.312e-12447.01Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:15... [more]
CBL5.220e-12447.01Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:15... [more]
CBL8.998e-12447.01Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:15... [more]
CBL1.127e-12347.01Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:15... [more]
CBLB3.687e-12147.15Cbl proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
sli-11.212e-9439.54Suppressor of LIneage defect [Source:UniProtKB/Tr... [more]
sli-12.939e-9439.54Suppressor of LIneage defect [Source:UniProtKB/Tr... [more]
sli-14.010e-9439.54Suppressor of LIneage defect [Source:UniProtKB/Tr... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Cbl3.823e-12147.87gene:FBgn0020224 transcript:FBtr0076614[more]
Cbl8.369e-11847.87gene:FBgn0020224 transcript:FBtr0076615[more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbl2.044e-12548.21Cbl proto-oncogene, E3 ubiquitin protein ligase [S... [more]
cblb1.286e-11946.88Cbl proto-oncogene B, E3 ubiquitin protein ligase ... [more]
cblb1.513e-11946.88Cbl proto-oncogene B, E3 ubiquitin protein ligase ... [more]
cblb2.031e-11946.88Cbl proto-oncogene B, E3 ubiquitin protein ligase ... [more]
cblc4.184e-10740.28Cbl proto-oncogene C, E3 ubiquitin protein ligase ... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbl8.468e-12246.63Cbl proto-oncogene, E3 ubiquitin protein ligase [S... [more]
cbl1.310e-12146.85Cbl proto-oncogene, E3 ubiquitin protein ligase [S... [more]
cbl4.346e-12146.85Cbl proto-oncogene, E3 ubiquitin protein ligase [S... [more]
cbl9.166e-12146.85Cbl proto-oncogene, E3 ubiquitin protein ligase [S... [more]
cblb1.570e-12047.67Cbl proto-oncogene B, E3 ubiquitin protein ligase ... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cbl7.277e-12547.28Casitas B-lineage lymphoma [Source:MGI Symbol;Acc:... [more]
Cbl1.281e-12447.28Casitas B-lineage lymphoma [Source:MGI Symbol;Acc:... [more]
Cbl1.760e-12447.28Casitas B-lineage lymphoma [Source:MGI Symbol;Acc:... [more]
Cblb3.278e-12047.15Casitas B-lineage lymphoma b [Source:MGI Symbol;Ac... [more]
Cblb3.278e-12047.15Casitas B-lineage lymphoma b [Source:MGI Symbol;Ac... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P22682|CBL_MOUSE8.957e-12447.28E3 ubiquitin-protein ligase CBL OS=Mus musculus OX... [more]
sp|P22681|CBL_HUMAN5.414e-12347.01E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX... [more]
sp|Q8K4S7|CBLB_RAT1.671e-11947.15E3 ubiquitin-protein ligase CBL-B OS=Rattus norveg... [more]
sp|Q3TTA7|CBLB_MOUSE3.459e-11947.15E3 ubiquitin-protein ligase CBL-B OS=Mus musculus ... [more]
sp|Q13191|CBLB_HUMAN6.505e-11947.15E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens ... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A448WE972.052e-14752.13Uncharacterized protein OS=Protopolystoma xenopodi... [more]
A0A504YUY06.234e-14256.23E3 ubiquitin protein ligase CBL OS=Fasciola gigant... [more]
A0A3P7NGE86.803e-14254.64Uncharacterized protein (Fragment) OS=Dibothriocep... [more]
A0A2H1BWT01.827e-14156.23CBL proto-oncogene, SH2-like domain protein OS=Fas... [more]
A0A4Z2D9L06.967e-14155.28E3 ubiquitin-protein ligase CBL OS=Schistosoma jap... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbl1.059e-12447.67Cbl proto-oncogene [Source:NCBI gene;Acc:103032411... [more]
cbl1.399e-12447.67Cbl proto-oncogene [Source:NCBI gene;Acc:103032411... [more]
cblb5.253e-11846.88Cbl proto-oncogene B [Source:NCBI gene;Acc:1030347... [more]
cblc1.166e-10441.10E3 ubiquitin-protein ligase CBL-like [Source:NCBI ... [more]
cblc1.166e-10441.10E3 ubiquitin-protein ligase CBL-like [Source:NCBI ... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cblc1.349e-5741.31Cbl proto-oncogene C, E3 ubiquitin protein ligase ... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO442349.658e-636.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000018206.22.907e-12447.12E3 ubiquitin-protein ligase CBL [Source:NCBI gene;... [more]
cbl4.860e-12247.68Cbl proto-oncogene [Source:NCBI gene;Acc:101170289... [more]
cblb5.780e-11846.07Cbl proto-oncogene B [Source:NCBI gene;Acc:1011574... [more]
cblc7.160e-10339.73E3 ubiquitin-protein ligase CBL [Source:NCBI gene;... [more]
cblc7.160e-10339.73E3 ubiquitin-protein ligase CBL [Source:NCBI gene;... [more]
back to top
BLAST of E3 ubiquitin-protein ligase CBL vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000056433.10.000e+099.65SMESG000056433.1[more]
SMESG000072524.13.766e-11037.88SMESG000072524.1[more]
SMESG000006795.19.778e-4131.52SMESG000006795.1[more]
SMESG000060298.14.984e-636.49SMESG000060298.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034412 ID=SMED30034412|Name=E3 ubiquitin-protein ligase CBL|organism=Schmidtea mediterranea sexual|type=transcript|length=1795bp
GTATATTTGATTTAATTTTAATAAATAAATTTAAAATTTTAGATGAATTA
AATTATTTTTTTAATGGCTGATGTGTCTTTCAATAATGTGCCATCAAACA
AAAATGTTATTAATTTTTTTCAAAATGTATTTTCTGAAAATTCAGGAAAA
TCTGGATTTATGAATATATTGGCCATAAATACTCACACTTCCAATCCTAA
TATTGATAAGAAGTCTCTAGAAAACGCATTAAAATTATTGGACAAGTGCA
AAAAGTTATATCTAAATTCTAAACTTAATTTAAAAAACAGCCCGCCATTT
TTAATCGGAACTATAACTGATATTCAATTGTTGTTAAATAATGTGATCTT
CTATTATAAAGACAAAATCGATGAATTATTAGGCATAACTTATTTTAAAG
TAATGCTTCTAACTATAATCGATCAATCTGAAAGACTTATAAAATTATTT
AAAGACGAAAAAGATCGTATTTTGCAAGTGTCATCGCCTGCTCGAAAAAA
ATTGACCAAACTTTCCTTAATATTTTCTCACGTATACAAAACTTTCAATG
AATTCTTTCAAAAGGGTTTTTATTGTGTCGAAAATTTTAGAATTACGAAA
TTAGATGCAGCAAATTGGTGGAAAGTTAATTTCAACGATAAAACTATAAT
ATCGTGGAAAAACTTTTACGAATCTCTGTCTCTAACTTATAAATTAAATG
ATCTAAGTCAAGGTATTGCTTTGAAAAGCACTATAAATTTGTGTTGCAAT
AATTATGTTACAATGTATGAATTCGATGTTTTTGTCAGATTATATCAACC
ATGGAATAATATATTAGAAACATGGAAAGCTCTGGCTGTATTGCATCCGG
GATATATGTCATTTATGACATATGATGATGTAAAATTAGTTTTAATGAAT
TTTATTGAAAACCCTGGTCCAGGAACTTATGTTTTTCGTTCCAGTTGTAC
TAAATTGGGACAGTGGGCTATTGGATATATAACTGAAGACAAACAAATTC
TTCAAACTATAATTCAAAATAAATCGTTAGCTCGTGCTCTCTTAGATGGG
GAAAAGGAAGGCTATTACAAATACCCGAATGGATCAATCACTTATAATGC
CTATCAACATCTTTACTCTCTTGTTCACAATTTAACACAAACTCATATAC
AAGTGTCCCATGAACAGTATAAAGTCTATTGTGAAATGGATTCTACATTT
GAACTGTGCAAAATCTGTTCAGAAAACGATAAAAACATCCGATTGGAACC
CTGCCAACACTTGCTATGTCGACCGTGTCTGGTTTCTTGGGAATCATCGA
GTGGATTAACTTGCCCGTTTTGTCGTCTGGAAATCAAATCAGTCGAAGAT
ATTGTAGTGAAACCATATGAAATGAAAGAGAGCGCCGATAAATTGACCGC
TCCACCGTTACCTCCACGGCCAATCATGTCCACGTCAACTATATCGACAA
ACAGCGACAACGACCTAATGGCAACAAGCAATATCGAATTGAATTATGCG
GTTCTCGATTTCCCAGATTACCCTATAGCGTCTAAAGCAACTCAAGTCAA
TTTCATGCCGACCTCGTCGCATAGCAACGGTTGCCAATTGCAAGATATAG
ATTCCCAACATGATTTGGAAAAAAATCTGAAAACTTTAATTGAGAATGAA
AAAATCGATATGAAAGTTGCAAAATTAATACTCAAAATCACGGATAATGA
CATTAATAAATCACGAACTATTTTAAAATACTTTAAAATCAAAGATGACA
TATTTTAATTTTGACCATTGTGATTCGATTGTTTTTTGATGCCAA
back to top

protein sequence of SMED30034412-orf-1

>SMED30034412-orf-1 ID=SMED30034412-orf-1|Name=SMED30034412-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=565bp
MADVSFNNVPSNKNVINFFQNVFSENSGKSGFMNILAINTHTSNPNIDKK
SLENALKLLDKCKKLYLNSKLNLKNSPPFLIGTITDIQLLLNNVIFYYKD
KIDELLGITYFKVMLLTIIDQSERLIKLFKDEKDRILQVSSPARKKLTKL
SLIFSHVYKTFNEFFQKGFYCVENFRITKLDAANWWKVNFNDKTIISWKN
FYESLSLTYKLNDLSQGIALKSTINLCCNNYVTMYEFDVFVRLYQPWNNI
LETWKALAVLHPGYMSFMTYDDVKLVLMNFIENPGPGTYVFRSSCTKLGQ
WAIGYITEDKQILQTIIQNKSLARALLDGEKEGYYKYPNGSITYNAYQHL
YSLVHNLTQTHIQVSHEQYKVYCEMDSTFELCKICSENDKNIRLEPCQHL
LCRPCLVSWESSSGLTCPFCRLEIKSVEDIVVKPYEMKESADKLTAPPLP
PRPIMSTSTISTNSDNDLMATSNIELNYAVLDFPDYPIASKATQVNFMPT
SSHSNGCQLQDIDSQHDLEKNLKTLIENEKIDMKVAKLILKITDNDINKS
RTILKYFKIKDDIF*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0000140anterior region of the whole animal
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036537Adaptor_Cbl_N_dom_sf
IPR036860SH2_dom_sf
IPR024162Adaptor_Cbl
IPR001841Znf_RING
IPR003153Adaptor_Cbl_N_hlx
IPR014741Adaptor_Cbl_EF_hand-like
IPR000980SH2
IPR011992EF-hand-dom_pair
IPR014742Adaptor_Cbl_SH2-like
IPR013083Znf_RING/FYVE/PHD
IPR017907Znf_RING_CS
IPR024159Cbl_PTB
Vocabulary: molecular function
TermDefinition
GO:0008270zinc ion binding
GO:0005515protein binding
GO:0004871signal transducer activity
GO:0005509calcium ion binding
GO:0001784phosphotyrosine binding
GO:0004842ubiquitin-protein transferase activity
GO:0016874ligase activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: biological process
TermDefinition
GO:0007166cell surface receptor signaling pathway
GO:0016567protein ubiquitination
GO:0023051regulation of signaling
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001841Zinc finger, RING-typeSMARTSM00184ring_2coord: 382..420
e-value: 2.6E-6
score: 36.9
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 382..421
score: 12.297
IPR014742Adaptor protein Cbl, SH2-like domainPFAMPF02762Cbl_N3coord: 261..341
e-value: 2.6E-37
score: 126.5
NoneNo IPR availableGENE3DG3DSA:1.10.238.10coord: 172..260
e-value: 2.0E-30
score: 107.1
NoneNo IPR availablePFAMPF14447Prok-RING_4coord: 382..425
e-value: 1.8E-12
score: 46.9
NoneNo IPR availablePANTHERPTHR23007:SF5E3 UBIQUITIN-PROTEIN LIGASE CBLcoord: 43..444
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 359..435
IPR014741Adaptor protein Cbl, EF hand-likePFAMPF02761Cbl_N2coord: 175..258
e-value: 4.6E-29
score: 100.9
IPR036537Adaptor protein Cbl, N-terminal domain superfamilyGENE3DG3DSA:1.20.930.20coord: 43..171
e-value: 2.7E-29
score: 103.6
IPR036537Adaptor protein Cbl, N-terminal domain superfamilySUPERFAMILYSSF47668N-terminal domain of cbl (N-cbl)coord: 48..171
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 351..436
e-value: 4.5E-18
score: 66.4
IPR003153Adaptor protein Cbl, N-terminal helicalPFAMPF02262Cbl_Ncoord: 47..171
e-value: 5.8E-30
score: 103.9
IPR036860SH2 domain superfamilyGENE3DG3DSA:3.30.505.10coord: 261..345
e-value: 3.1E-36
score: 125.1
IPR036860SH2 domain superfamilySUPERFAMILYSSF55550SH2 domaincoord: 261..341
IPR024162Adaptor protein CblPANTHERPTHR23007CBLcoord: 43..444
IPR017907Zinc finger, RING-type, conserved sitePROSITEPS00518ZF_RING_1coord: 397..406
IPR024159Adaptor protein Cbl, PTB domainPROSITEPS51506CBL_PTBcoord: 41..349
score: 67.842
IPR011992EF-hand domain pairSUPERFAMILYSSF47473EF-handcoord: 175..259