Indoleamine 2,3-dioxygenase 1

Overview
NameIndoleamine 2,3-dioxygenase 1
Smed IDSMED30034259
Length (bp)1410
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Indoleamine 2,3-dioxygenase 1 (SMED30034259) t-SNE clustered cells

Violin plots show distribution of expression levels for Indoleamine 2,3-dioxygenase 1 (SMED30034259) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Indoleamine 2,3-dioxygenase 1 (SMED30034259) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Indoleamine 2,3-dioxygenase 1 (SMED30034259) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30034259

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pigment cellSMED30034259h1SMcG0013792 SmedASXL_013301SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
cephalic gangliaSMED30034259h1SMcG0013792 dd_Smed_v4_13826_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30034259h1SMcG0013792 dd_Smed_v4_13826_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Human
Match: IDO2 (indoleamine 2,3-dioxygenase 2 [Source:HGNC Symbol;Acc:HGNC:27269])

HSP 1 Score: 181.8 bits (460), Expect = 7.700e-52
Identity = 120/377 (31.83%), Postives = 197/377 (52.25%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-----SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEIN-----SEFLQDR 1145
            L    Y +    GFL+  + K EL  +Y PW+ I   L  L++ + L+ ++DKMP+LS + L    +    H +L+F T  YVW + +A+  ++LP++L++P  ++S  LGL PIL HSD+VL N    +TK   D   L I N     S     + + F   TA +E    P I+A+    + I+    E ++  L+ + L++  + +++   ++ ++PD F+  +R FL GW  D  A   GL+YE    S   ++  GGSAAQS      D    I+HS +S  F   M+ YM   H+ FI D+ +   L  +I    +D LL  A+N+C+ A++  R+ H+ +VTK++I  + K    + N      + L+DR
Sbjct:   14 LSLESYHISEEYGFLLPDSLK-ELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTN----WTKKDPD-GFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGW-KDNPAMPAGLMYEGV--SQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLT-AYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDR 380          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Human
Match: IDO2 (indoleamine 2,3-dioxygenase 2 [Source:HGNC Symbol;Acc:HGNC:27269])

HSP 1 Score: 181.415 bits (459), Expect = 1.374e-51
Identity = 120/377 (31.83%), Postives = 197/377 (52.25%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-----SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEIN-----SEFLQDR 1145
            L    Y +    GFL+  + K EL  +Y PW+ I   L  L++ + L+ ++DKMP+LS + L    +    H +L+F T  YVW + +A+  ++LP++L++P  ++S  LGL PIL HSD+VL N    +TK   D   L I N     S     + + F   TA +E    P I+A+    + I+    E ++  L+ + L++  + +++   ++ ++PD F+  +R FL GW  D  A   GL+YE    S   ++  GGSAAQS      D    I+HS +S  F   M+ YM   H+ FI D+ +   L  +I    +D LL  A+N+C+ A++  R+ H+ +VTK++I  + K    + N      + L+DR
Sbjct:   27 LSLESYHISEEYGFLLPDSLK-ELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTN----WTKKDPD-GFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGW-KDNPAMPAGLMYEGV--SQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLT-AYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDR 393          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Human
Match: IDO1 (indoleamine 2,3-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:6059])

HSP 1 Score: 159.073 bits (401), Expect = 2.675e-43
Identity = 109/364 (29.95%), Postives = 188/364 (51.65%), Query Frame = 3
Query:   60 DYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYEN--EDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSA---KSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSE 1130
            +Y +D   GF +  N +  L  +Y+ W+ I  +L  L+E+  LRE ++K+ +LSI+ LT  +       +L   T AYVW K   ++ K+LP++++VP  +LS KL L PIL ++D VL N    D  K ++ +++ V+ +  + + +   F   +  +E   +  I+ I  ++  +  ++ + ++  L  I+  L    +     ++ +NP  F   +R +L GW G+      GL+YE   ED      E  GGSA QS   Q  D L  IQ +A    + +F   M+ YM   HRNF+  +++   +  F+     D  L EA++ C+ A+   R+ H+Q+VTK+I+ P+ +  KE   SE
Sbjct:   14 EYHIDEEVGFAL-PNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFF-LVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSD-GLVYEGFWEDPK----EFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLS-KGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSE 369          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Human
Match: IDO1 (indoleamine 2,3-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:6059])

HSP 1 Score: 159.073 bits (401), Expect = 2.675e-43
Identity = 109/364 (29.95%), Postives = 188/364 (51.65%), Query Frame = 3
Query:   60 DYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYEN--EDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSA---KSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSE 1130
            +Y +D   GF +  N +  L  +Y+ W+ I  +L  L+E+  LRE ++K+ +LSI+ LT  +       +L   T AYVW K   ++ K+LP++++VP  +LS KL L PIL ++D VL N    D  K ++ +++ V+ +  + + +   F   +  +E   +  I+ I  ++  +  ++ + ++  L  I+  L    +     ++ +NP  F   +R +L GW G+      GL+YE   ED      E  GGSA QS   Q  D L  IQ +A    + +F   M+ YM   HRNF+  +++   +  F+     D  L EA++ C+ A+   R+ H+Q+VTK+I+ P+ +  KE   SE
Sbjct:   14 EYHIDEEVGFAL-PNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFF-LVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSD-GLVYEGFWEDPK----EFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLS-KGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSE 369          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Human
Match: IDO1 (indoleamine 2,3-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:6059])

HSP 1 Score: 86.6557 bits (213), Expect = 2.969e-19
Identity = 45/121 (37.19%), Postives = 72/121 (59.50%), Query Frame = 3
Query:   60 DYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN 422
            +Y +D   GF +  N +  L  +Y+ W+ I  +L  L+E+  LRE ++K+ +LSI+ LT  +       +L   T AYVW K   ++ K+LP++++VP  +LS KL L PIL ++D VL N
Sbjct:   14 EYHIDEEVGFAL-PNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLAN 133          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Zebrafish
Match: ido1 (indoleamine 2,3-dioxygenase 1 [Source:ZFIN;Acc:ZDB-GENE-080228-2])

HSP 1 Score: 176.022 bits (445), Expect = 1.550e-49
Identity = 112/371 (30.19%), Postives = 193/371 (52.02%), Query Frame = 3
Query:   42 SMLEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN---TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQD 1142
            +++    + +    GF++ +    +L  YY PW++I  N+  L+ +++LR  I  MP+L+ +LL +  +    H  L+     YVW + + E  K+LP++LSVP   +S +LGL PIL H+D VL N   T  +   ++ + +LL+   S+    +   F   T  +E    P ++AI ++ + +     E V   L VIS ++ SM++++K  +E ++P  F+  +R FL GW  D  +   GL+YE  D    E    GGSAAQS     LD L  IQH   +  F   M+ YM   H+ FI+++     L  F+ + + D+ L  A ++C+  +  +R  H+ +VT+FI  P+ +  +   N + L +
Sbjct:   10 TVVSLRKFHISEEYGFILPE-PLMDLPVYYKPWMDIGRNVTELISSHSLRLRIHNMPLLTTDLLRTHRELRLAHLTLSVMAMGYVWQEGEKETVKMLPQTLSVPFCDVSRRLGLPPILIHADTVLANWKKTDPNGPFTMENLELLL---SLPGGQSLRGFFLVTLLVELAAVPGLKAIIDVINGVHYNDIERVTKALDVISQSIDSMKQALKRMHEYVDPSIFYGVIRIFLSGW-KDNPSMAEGLVYEGVDDQPMEFS--GGSAAQSSILHCLDELLGIQHEGNNGAFLKRMRDYMPPSHKQFIQEISICPSLRDFVLQQA-DERLTHAFDKCVAGLVDFRNCHINIVTRFITIPASRAKQLRANKQNLME 372          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Mouse
Match: Ido2 (indoleamine 2,3-dioxygenase 2 [Source:MGI Symbol;Acc:MGI:2142489])

HSP 1 Score: 167.548 bits (423), Expect = 1.238e-46
Identity = 109/359 (30.36%), Postives = 179/359 (49.86%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-----SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATE-IECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            L    Y +    GFL+  N    L  +Y PW+ I + L  L+E   LR ++ +MP+L    L S+ +    H  LA  T  +VW + + +  K+LP+SL++P  ++S  LGL PIL HSD+VL N    +TK  + +  L I N     S     +   F   T  +E    P ++A+    + I     + ++  L+ + L++  +  ++   ++ ++PD F+  +R FL GW  D  A   GL+YE   G ATE ++  GGSAAQS      D    I+H  +S  F   M+ YM   H+ F+ D+     L  +I        L+ A+N+C+ A+   R+ H+ VV ++II+ + +
Sbjct:   14 LSLGRYHISEEYGFLL-PNPLEALPDHYKPWMEIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQPQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTN----WTKR-NPEGPLEISNLETIISFPGGESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPDIFYSVIRIFLSGW-KDNPAMPVGLVYE---GVATEPLKYSGGSAAQSSVLHAFDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLM-AYNQCVEALGELRSYHINVVARYIISAATR 361          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Mouse
Match: Ido1 (indoleamine 2,3-dioxygenase 1 [Source:MGI Symbol;Acc:MGI:96416])

HSP 1 Score: 166.007 bits (419), Expect = 5.263e-46
Identity = 111/365 (30.41%), Postives = 187/365 (51.23%), Query Frame = 3
Query:   54 FSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQ---KFFDSMKLYMIKEHRNFIRDVDTFIDLEAF-IRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSE 1130
              D+ +D + GF +  +   EL   Y PW+ +  NL  L+E   LRE ++K+P LS + L         H  L + T AYVW++   ++ K+LP++++VP  +LS+KLGL PIL ++D VL N    D    ++ +++ ++ +    + +   F   +  +E   SP I+AI  +   +  +  + +   L  I+ +L   +E  K   + ++PD F   +R +L GW       + GLLYE    +       GGSA QS   Q LD L  I+H A  +   +F   M+ YM   HRNF+  +++   +  F I ++++D  L +A+NEC+N +   R  H+ +V  +I+ PSKK   +   SE
Sbjct:   16 LEDHHIDEDVGFAL-PHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLV-SLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPE-GLLYEGVWDTPKMFS--GGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNED--LTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSE 373          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Mouse
Match: Ido1 (indoleamine 2,3-dioxygenase 1 [Source:MGI Symbol;Acc:MGI:96416])

HSP 1 Score: 122.865 bits (307), Expect = 4.826e-31
Identity = 87/287 (30.31%), Postives = 150/287 (52.26%), Query Frame = 3
Query:  288 AYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQ---KFFDSMKLYMIKEHRNFIRDVDTFIDLEAF-IRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSE 1130
            AYVW++   ++ K+LP++++VP  +LS+KLGL PIL ++D VL N    D    ++ +++ ++ +    + +   F   +  +E   SP I+AI  +   +  +  + +   L  I+ +L   +E  K   + ++PD F   +R +L GW       + GLLYE    +       GGSA QS   Q LD L  I+H A  +   +F   M+ YM   HRNF+  +++   +  F I ++++D  L +A+NEC+N +   R  H+ +V  +I+ PSKK   +   SE
Sbjct:    2 AYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLV-SLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPE-GLLYEGVWDTPKMFS--GGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNED--LTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSE 282          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. UniProt/SwissProt
Match: sp|Q01966|MYG_HALDV (Myoglobin OS=Haliotis diversicolor OX=36095 PE=1 SV=2)

HSP 1 Score: 187.578 bits (475), Expect = 1.161e-53
Identity = 109/353 (30.88%), Postives = 177/353 (50.14%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSK 1100
            ++ S Y V  + GFL+   Q   L  Y+ PW  +  +L  L+ ++  R+ + +MP+L    L  + Q    H  L   TS Y+W + +    + LP+ ++ PL  +S+ LGL P+L + D+ L N        V   D+ V+ N        W  F +    +E       +++ N+ D        ++ S L  ++ T+ +M+ ++   N+ + PD+F+  +RPFL G+GG      GGL+YE    S   +  IGGSAAQS   Q+LD L  + HS   Q F D +  YMI  H+  + D+         I   +KD  L +A++ C+ A++ YRT H+QVVTK+I+  SK
Sbjct:    4 IQLSKYHVSKDIGFLLEPLQDV-LPDYFAPWNRLAKSLPDLVASHKFRDAVKEMPLLDSSKLAGYRQKRLAHLQLVLITSGYLWQEGEGGAVQRLPECVAKPLWNVSNDLGLKPVLTYGDVCLTNC------RVKGGDIEVMYNLPGGAGTEW--FLKVCGLVELTLGKGAQSVQNVLDGAKANDKAKMTSGLTELTTTIGNMQAALAKMNDNLTPDHFYNVLRPFLGGFGGPASPISGGLIYEGV--SDAPVTMIGGSAAQSSAMQLLDNLLGVTHSPDKQAFLDEISNYMIPAHKQLLADLTKMPRKVPQIVAEAKDANLSKAYSGCVAALTQYRTYHIQVVTKYIVTASK 345          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. UniProt/SwissProt
Match: sp|P51537|MYG_HALMK (Myoglobin OS=Haliotis madaka OX=81897 PE=2 SV=2)

HSP 1 Score: 187.193 bits (474), Expect = 1.941e-53
Identity = 112/353 (31.73%), Postives = 177/353 (50.14%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSK 1100
            ++ S Y V  + GFL+   Q   L  Y++PW  +  +L  L+ ++  R+ + +MP+L    L  + Q    H  L   TS Y+W + +    + LP+ +S PL  +S+ LGL P+L  +D+ L N        V + D+ V+ N        W  F +    +E  F    +AI N+ D        ++ S    ++  + +M+ ++   NE + P++F+  +RPFL G+GG      GGL+YE    S   +  IGGSAAQS T QVLD L  I HS + Q F D ++ YM   H+  + D+         +   +KD  L +A N C+ A   YR+ H+QVVTK+I+  SK
Sbjct:    4 IQLSKYHVSKDIGFLLEPLQDV-LPDYFEPWNRLAKSLPELVASHKFRDAVKEMPLLDQSKLAGYRQKRLAHLQLVLITSGYLWQEGEGGAVQRLPECVSKPLWNVSNDLGLKPVLTFADICLTNC------KVKNGDIEVMYNLPGGAGTEW--FLKVCGLVELAFGKSGQAIQNVLDGAKANDKAKMASGFTDLTAAIGNMQTALARMNENLTPEHFYNGVRPFLNGFGGPASPISGGLVYEGV--SDKPVTMIGGSAAQSSTMQVLDGLLGITHSPEKQAFLDEIRNYMPPSHKQMLADLTNMPRKVPQVVAETKDANLTKAFNGCVAAFVQYRSYHIQVVTKYIVTASK 345          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. UniProt/SwissProt
Match: sp|Q6ZQW0|I23O2_HUMAN (Indoleamine 2,3-dioxygenase 2 OS=Homo sapiens OX=9606 GN=IDO2 PE=1 SV=4)

HSP 1 Score: 181.415 bits (459), Expect = 6.597e-51
Identity = 120/377 (31.83%), Postives = 197/377 (52.25%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-----SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEIN-----SEFLQDR 1145
            L    Y +    GFL+  + K EL  +Y PW+ I   L  L++ + L+ ++DKMP+LS + L    +    H +L+F T  YVW + +A+  ++LP++L++P  ++S  LGL PIL HSD+VL N    +TK   D   L I N     S     + + F   TA +E    P I+A+    + I+    E ++  L+ + L++  + +++   ++ ++PD F+  +R FL GW  D  A   GL+YE    S   ++  GGSAAQS      D    I+HS +S  F   M+ YM   H+ FI D+ +   L  +I    +D LL  A+N+C+ A++  R+ H+ +VTK++I  + K    + N      + L+DR
Sbjct:   27 LSLESYHISEEYGFLLPDSLK-ELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTN----WTKKDPD-GFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGW-KDNPAMPAGLMYEGV--SQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLT-AYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDR 393          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. UniProt/SwissProt
Match: sp|Q9ERD9|I23O1_RAT (Indoleamine 2,3-dioxygenase 1 OS=Rattus norvegicus OX=10116 GN=Ido1 PE=2 SV=1)

HSP 1 Score: 173.326 bits (438), Expect = 6.281e-48
Identity = 110/355 (30.99%), Postives = 184/355 (51.83%), Query Frame = 3
Query:   54 FSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQH---SAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
              +Y +D + GF +    + EL   Y PWI +  NL  L+E   LRE ++K+P L  E L         H  L + T AYVW++   +I K+LP++L+VP  +LS+KLGL PIL ++D VL N    D    ++ +++ ++ +    + +   F   +  +E   SP I+AI  +   + ++  + +   L  I+ +L   +E  K   + ++PD F   +R +L GW G+    + GLLYE    +  +    GGSA QS   Q LD L  I+H      + +F   M+ YM   HRNF+  +++   +  F+    +++ L EA+NEC+N +   R  H+ +V  +I+ PSK+
Sbjct:   16 LEEYHIDEDVGFALPHPLE-ELPDTYRPWILVARNLPKLIENGKLREEVEKLPTLRTEELRGHRLQRLAHLALGYITMAYVWNRGDDDIRKVLPRNLAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLV-SLMVEIAASPAIKAIPTVSSAVEHQDPKALEKALCSIAASLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKGNPKLPE-GLLYEGVWDTPKKFS--GGSAGQSSIFQSLDVLLGIKHDVGEGSAAEFLQEMREYMPPAHRNFLSSLESAPPVREFV-ILRRNEDLKEAYNECVNGLVSLRMFHLSIVDTYIVKPSKQ 364          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. UniProt/SwissProt
Match: sp|Q8R0V5|I23O2_MOUSE (Indoleamine 2,3-dioxygenase 2 OS=Mus musculus OX=10090 GN=Ido2 PE=1 SV=3)

HSP 1 Score: 167.548 bits (423), Expect = 8.658e-46
Identity = 109/359 (30.36%), Postives = 179/359 (49.86%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-----SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATE-IECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            L    Y +    GFL+  N    L  +Y PW+ I + L  L+E   LR ++ +MP+L    L S+ +    H  LA  T  +VW + + +  K+LP+SL++P  ++S  LGL PIL HSD+VL N    +TK  + +  L I N     S     +   F   T  +E    P ++A+    + I     + ++  L+ + L++  +  ++   ++ ++PD F+  +R FL GW  D  A   GL+YE   G ATE ++  GGSAAQS      D    I+H  +S  F   M+ YM   H+ F+ D+     L  +I        L+ A+N+C+ A+   R+ H+ VV ++II+ + +
Sbjct:   14 LSLGRYHISEEYGFLL-PNPLEALPDHYKPWMEIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQPQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTN----WTKR-NPEGPLEISNLETIISFPGGESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPDIFYSVIRIFLSGW-KDNPAMPVGLVYE---GVATEPLKYSGGSAAQSSVLHAFDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLM-AYNQCVEALGELRSYHINVVARYIISAATR 361          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. TrEMBL
Match: Q6F3I3 (Molluscan indoleamine 2,3-dioxygenase like protein I OS=Haliotis diversicolor OX=36095 GN=MIP-I PE=2 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 7.235e-59
Identity = 114/358 (31.84%), Postives = 203/358 (56.70%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDV-DTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKE 1115
            ++ SDY V  +TGFL+ +N +  L  Y++PW  +   +  L+  +++RE +++MP+L    LT + Q    H  L   TS Y+W +  A + + LP+ ++VPL  +S+KLGL P++CH DM L N    +T+   D +++      + ++ W  F + T  +E  F+  ++++  + D ++ +   +V S L  +++T+ +M+ +MK  +E ++   F+  +RP+L GWGG       GL++E    S    + IGGS AQS T Q++D L  + HS   Q F + M+ YM   HR  + DV D    L   +   S+D  L  A+++C+ A++ +R+ H+Q+VTK++++ SKK  +E
Sbjct:    5 IQLSDYHVSRDTGFLL-ENPQEYLPDYFEPWNRVAKRMPDLVSRHSMREAVEEMPLLDHSRLTGYRQKRLAHMQLVLITSGYLWQEGDAGVVQRLPECVAVPLWHVSNKLGLKPVICHPDMCLANW--KYTEDQRDIEVIYTVPGGSSSV-W--FFKVTCFVEMAFAKGLQSVQEVLDGVMEDDNVKVTSGLTGMTITVGNMQSAMKRMHEHLSVPTFYNTVRPYLCGWGGPSSPLPNGLIFEGV--SEKPFQVIGGSTAQSTTLQLMDILLGVTHSPDKQAFLNEMRNYMPPGHRQLLLDVMDMPRKLTCMVAD-SEDSELTTAYSKCLAAVTQFRSYHIQMVTKYVVSASKKGSRE 353          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. TrEMBL
Match: Q6F3I4 (Molluscan indoleamine 2,3-dioxygenase like protein II OS=Haliotis diversicolor OX=36095 GN=MIP-II PE=2 SV=1)

HSP 1 Score: 205.682 bits (522), Expect = 5.752e-58
Identity = 115/358 (32.12%), Postives = 202/358 (56.42%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDV-DTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKE 1115
            ++ SDY V  +TGFL+ +N +  L  Y++PW  +   +  L+   ++RE +++MP+L    LT + Q    H  L   TS Y+W +  A + + LP+ ++VPL  +S+ LGL P++CH DM L N    +T+   D +++      + ++ W  F + T  +E  F+  ++++  + D ++ +   +V S L  +++T+ +M+ +MK  +E ++   F+  +RP+L GWGG       GL++E    S    + IGGSAAQS T Q++D L  + HS   Q F + M+ YM   HR  + DV D    L   +   S+D  L  A+++C+ A++ +R+ H+QVVTK++++ SKK  +E
Sbjct:    5 IQLSDYHVSRDTGFLL-ENPQEYLPDYFEPWNRLAKRMPDLVSRYSMREAVEEMPLLDHSRLTGYCQKRLAHMQLVLITSGYLWQEGDAGVVQRLPECVAVPLWHVSNTLGLKPVICHPDMCLANW--KYTEDQRDIEVIYTVPGGSSSV-W--FFKVTCFVEMAFAKGLQSVQEVLDGVMEDDNVKVTSGLTGMTITVGNMQSAMKRMHEHLSVPTFYNTVRPYLGGWGGPSSPLPNGLIFEGV--SEKPFQVIGGSAAQSTTLQLMDILLGVTHSPDKQAFLNEMRNYMPPAHRQLLLDVMDMPRKLTCMVAD-SEDSELTTAYSKCLAAVTQFRSYHIQVVTKYVVSASKKGSRE 353          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. TrEMBL
Match: A0A5F4WIH1 (Indoleamine 2,3-dioxygenase 2 OS=Callithrix jacchus OX=9483 GN=IDO2 PE=4 SV=1)

HSP 1 Score: 192.971 bits (489), Expect = 5.306e-53
Identity = 116/353 (32.86%), Postives = 190/353 (53.82%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            L    Y +    GFL+  + K EL  +Y PW+ I   L  L++ + LR ++DKMP+LS + L    +    H +L+F T  YVW + +A+  ++LP++L++PL ++S  LGL PIL HSD+VL N    +TK   D +L  I  S     + + F   T  +E    P I+A+    + I+    E ++  LK + L++  + +++   ++ ++PD F+  +R FL GW  D  A   GL+YE    S   ++  GGSAAQS      D    I+HS +S  F   M+ YM   H+ F+ D+ +   L  +I   S  + L+ A+N+C+ A++  R+ H+ +VTK+II  + K
Sbjct:   14 LSLERYHISEEYGFLLPDSLK-ELPDHYRPWMEIANKLTQLIDAHQLRVHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPLVEVSRNLGLPPILVHSDLVLTN----WTKKDPDGNLETII-SFPGGESLHGFILVTVLVEKAAVPGIKALVQAMNAILQPSQEALLQALKQLRLSIQDITKTLGKMHDYVDPDIFYAVIRIFLSGW-KDNPAMPAGLMYEGV--SKEPLKYSGGSAAQSTVLHAFDEFLGIRHSQESADFLYRMRDYMPPSHKAFVEDIRSAPSLRDYILS-SGQEYLLTAYNQCLQALAELRSYHITIVTKYIITAAAK 356          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. TrEMBL
Match: A0A4E0R345 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_007104 PE=4 SV=1)

HSP 1 Score: 192.586 bits (488), Expect = 8.592e-53
Identity = 112/384 (29.17%), Postives = 195/384 (50.78%), Query Frame = 3
Query:   42 SMLEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYE-------------------------NEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKE 1115
            SM   + Y +   TG ++ +N    L  YYDPW  +  ++G L  TN LRE+I  MPV++++   ++E+  + H I+ FA S YVWS  + + P +LP  +SVPL   S +LG+ PIL H D+VL N     T+++ +     + N   ++ +W  F   +  +E  F+PI     ++ D         ++ +L  I   L    +S+  F E ++ + F+  +RP + GW       + G+++E                         +E+ +   + C+G +AAQS   Q +DTL +IQH  K+++FFD+M++YMI EHR F++D+     L   +++   D+L   A   C  A+  +R  H+++V +FI  P+ +   +
Sbjct:    5 SMKPLNFYRLSNRTGAVL-ENPVNGLPPYYDPWNRLARDMGELCRTNQLREFIKTMPVINVQPSLTYEELRFAHKIMTFAASTYVWSTGEDDAPDVLPAQISVPLLTASLELGIPPILTHQDLVLCNCAASVTENIPE-----VINLPTQHESWKHFIELSGMVEISFAPIFSLFSDIIDAQNPLNEANIVYSLGRIRQVLDKTGDSLSIFYERLDSNEFYVHLRPIMCGWNRKPI--ENGIVFEGVTKTYLDSKSTSFALEAVKIRACDDEENNWARMSCMGANAAQSICLQAIDTLLQIQHEPKNEEFFDAMRMYMIPEHRIFLQDLKKNSHLGEIVQETHSDELQ-SAFKACTEALRRFRDKHLELVVEFIEKPANQQAAK 379          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. TrEMBL
Match: G1RPS9 (Indoleamine 2,3-dioxygenase 2 OS=Nomascus leucogenys OX=61853 GN=IDO2 PE=4 SV=2)

HSP 1 Score: 192.586 bits (488), Expect = 1.413e-52
Identity = 120/377 (31.83%), Postives = 198/377 (52.52%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKN-----SMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEIN-----SEFLQDR 1145
            L    Y +    GFL+  + K EL  +Y PW+ I   L  L++ + LR ++DKMP+LS + L    +    H +L+F T  YVW + +A+  ++LP++L++P  ++S  LGL PIL HSD+VL N    +TK   D   L I N     S     + + F   TA +E   +P I+A+    + I+    E ++  L+ + L++  + +++   ++ ++PD F+  +R FL GW  D  A   GL+YE    S   ++  GGSAAQS      D    I+HS +S  F   M+ YM   H+ FI D+ +   L  ++    +D LL  A+N+C+ A++  R+ H+ +VTK++I  + K    + N      + L+DR
Sbjct:   27 LSLESYHISEEYGFLLPDSLK-ELPDHYRPWMEIANKLPQLIDAHQLRTHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTN----WTKKDPD-GFLEIGNLETIISFPGGESLHGFILVTALVEKAAAPGIKALVQATNAILQPNQEALLQALQGLRLSIQDITKTLGQMHDYVDPDIFYAVIRIFLSGW-KDNPAMPAGLVYEGV--SQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESADFLYRMRDYMPPSHKAFIEDIHSAPSLRDYVLSSGQDHLLT-AYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLQGPPQALKDR 393          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Cavefish
Match: ido1 (indoleamine 2,3-dioxygenase 2-like [Source:NCBI gene;Acc:103034408])

HSP 1 Score: 176.407 bits (446), Expect = 6.409e-50
Identity = 114/356 (32.02%), Postives = 182/356 (51.12%), Query Frame = 3
Query:   48 LEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN---TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            L    Y++    GF + +  + EL  Y+ PW++I   +  L+  ++LR  + ++P+L  + L S  +    H  L+  T  YVW + +A++ K+LP++L++P  ++S KLGL PIL H+D VL N   T  D +  + + +LL    S+    +   F   T  +E    P ++AI      + +     V   L VIS  L SM+E++K  ++ ++P  F+  MR FL GW  D  +   GL+YE     A  +E  GGSAAQS     LD L  I+H  KS  F   M+ YM   H+ FI  +     L  F+ K   D+ L EA   C++ +  +R  H+ VV++FI  P+ +
Sbjct:   12 LSLKKYYISEEYGFALPEPLR-ELPPYFQPWMDIAGRVSELISEHSLRSSVHELPLLETDSLQSHRELRLAHLALSIITMGYVWQEGEADLVKVLPQNLAIPFWEVSQKLGLPPILTHADGVLANWRKTDPDGSMDIENLELLF---SLPGGKSVRGFFLVTLLVELAAVPGLKAIPEAIGGVYDGDVSVVNKALDVISQALDSMKEALKLMHDYVDPSIFYGVMRIFLSGW-KDNPSMPDGLVYEGV--QAEPMEFSGGSAAQSSLLHCLDELLGIKHEEKSGAFLTRMRGYMPPFHKRFIEHISRSPSLRDFVLKQG-DESLTEAFEGCVDRLVAFRNFHINVVSRFITIPAAR 359          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Cavefish
Match: ido1 (indoleamine 2,3-dioxygenase 2-like [Source:NCBI gene;Acc:103034408])

HSP 1 Score: 176.022 bits (445), Expect = 6.783e-50
Identity = 113/345 (32.75%), Postives = 178/345 (51.59%), Query Frame = 3
Query:   81 TGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN---TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            T F I+   + EL  Y+ PW++I   +  L+  ++LR  + ++P+L  + L S  +    H  L+  T  YVW + +A++ K+LP++L++P  ++S KLGL PIL H+D VL N   T  D +  + + +LL    S+    +   F   T  +E    P ++AI      + +     V   L VIS  L SM+E++K  ++ ++P  F+  MR FL GW  D  +   GL+YE     A  +E  GGSAAQS     LD L  I+H  KS  F   M+ YM   H+ FI  +     L  F+ K   D+ L EA   C++ +  +R  H+ VV++FI  P+ +
Sbjct:   11 TAFFISGLLQRELPPYFQPWMDIAGRVSELISEHSLRSSVHELPLLETDSLQSHRELRLAHLALSIITMGYVWQEGEADLVKVLPQNLAIPFWEVSQKLGLPPILTHADGVLANWRKTDPDGSMDIENLELLF---SLPGGKSVRGFFLVTLLVELAAVPGLKAIPEAIGGVYDGDVSVVNKALDVISQALDSMKEALKLMHDYVDPSIFYGVMRIFLSGW-KDNPSMPDGLVYEGV--QAEPMEFSGGSAAQSSLLHCLDELLGIKHEEKSGAFLTRMRGYMPPFHKRFIEHISRSPSLRDFVLKQG-DESLTEAFEGCVDRLVAFRNFHINVVSRFITIPAAR 348          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Sea Lamprey
Match: ido1 (indoleamine 2,3-dioxygenase 1 [Source:ZFIN;Acc:ZDB-GENE-080228-2])

HSP 1 Score: 139.428 bits (350), Expect = 4.764e-37
Identity = 107/362 (29.56%), Postives = 169/362 (46.69%), Query Frame = 3
Query:   63 YFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDK----DLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNE-MNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAK---SQKFFDSMKLYMIKEHRNFIRDVDTFIDLEA-FI-RKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKE 1115
            + +    GF +  +  T L  YY PW+ +  NL  L+ET+ LRE + +MP LSI LL S  Q    H +L+F TS  VW +      K+LP+S++VP   +S  LGL PI+ H+D VL N    D    +S+     D LV    +    N   F   T  +EF   P I  +    + +       +  +L  ++  +  M +++   ++ ++P  F   +R FL GW  +      GL YE      T     GGSAAQS      D    I+H  K   +  F   M+ YM+  H  FI  +     + + F+ R    +     A+N C++A++  R++H+ VVT++I   S +  +E
Sbjct:   23 FHISKTCGFAL-PDPLTSLPEYYAPWMELAANLTELIETHTLRERVMQMPELSIGLLQSHRQLRLAHLVLSFITSGVVWQEGDKAPTKVLPRSVAVPFCAVSKCLGLPPIIVHADGVLANWRRRDADGYLSEMYINLDTLV---RLPGGANSRYFFLCTVMVEFAAVPGIIGLVKCVEAVRAADEATLKESLLEVAEAIHGMIKALSTMHDHVDPAVFFGVIRIFLSGWMDNPV--LDGLHYEGVGD--TPYMYSGGSAAQSSLLHCFDAALGIEHDPKHVNTGSFLARMREYMLPRHSEFICWLADGPSIRSHFVSRSTPPESSARAAYNACVSALTRLRSDHIAVVTRYITVQSARARRE 376          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Yeast
Match: BNA2 (Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp [Source:SGD;Acc:S000003839])

HSP 1 Score: 138.272 bits (347), Expect = 1.352e-36
Identity = 108/375 (28.80%), Postives = 187/375 (49.87%), Query Frame = 3
Query:   63 YFVDFNTGFLINQNQKTELSSY-YDPWINIQVNLGSLM-ETNNLREYIDKMPVLSIE--LLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYV-DFTKSVS----DKDLLVIKNSMNKNINWNIFQRETARIEFCFSP-------IIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFN-EMNPDYFHREMRPFLLGWGGDGYAHQG---GLLYENEDGSATEIECI-GGSAAQSPTSQVLDTLFKIQHSAKSQK---------FFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPS 1097
            Y +  + GFL ++   T LSS  Y  W  I  +L SL+ E N +R  ID + VL ++  +L    +    +SIL F   AY+W+        +LP+ ++ PL + +  LG+ P+  +S +VL+N  V D  K       D + +   N+    ++ + F   + R E   S        I+RAI +      ++    VI  L+ ++ T+  + +++     +  P+ F+ ++RPFL GW     +H G   G+ Y    G+  +     GGS AQS   Q LD L  ++H+A +           + D MK YM +EHR F+  +++  ++  ++ + + ++ L EA+  CI+ + I+R NH+Q+VTK+II PS
Sbjct:   26 YCISPHHGFLDDRLPLTRLSSKKYMKWEEIVADLPSLLQEDNKVRSVIDGLDVLDLDETILGDVRELRRAYSILGFMAHAYIWASGTPR--DVLPECIARPLLETAHILGVPPLATYSSLVLWNFKVTDECKKTETGCLDLENITTINTFTGTVDESWFYLVSVRFEKIGSACLNHGLQILRAIRS-----GDKGDANVIDGLEGLAATIERLSKALMEMELKCEPNVFYFKIRPFLAGW--TNMSHMGLPQGVRY----GAEGQYRIFSGGSNAQSSLIQTLDILLGVKHTANAAHSSQGDSKINYLDEMKKYMPREHREFLYHLESVCNIREYVSRNASNRALQEAYGRCISMLKIFRDNHIQIVTKYIILPS 387          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Nematostella
Match: EDO38059 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDW8])

HSP 1 Score: 147.517 bits (371), Expect = 7.308e-40
Identity = 98/363 (27.00%), Postives = 183/363 (50.41%), Query Frame = 3
Query:   54 FSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYV-DFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNEM-NPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQ-KFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFII--------NPSKKMV 1109
              DY V    GF+ +++   +L  Y+ PW  +   L  + +    R +I+++P+L    LTS  + +  + +L   + +YVW + +    K+LPKSL++PL  +S+ LG+ PIL H    ++N  V D ++ ++  ++  I N+     + + F     ++E  F   + ++      ++++  + +   L  +   ++ +  ++   +++  P  F+  +R FL GW     A   GL+YE    S+T  +  GGSAA+S   QVLD    I+H + S+  F   M+ +M  +H  FI  V+    +  ++   SKDQ L E +N C+ A+  YR  H+ +VTK+II        NP++++ 
Sbjct:    9 LEDYEVSPTRGFIQDEDPLQQLPEYFSPWEEVCERLPEMWKDETTRHWIEQLPLLDHNKLTSAREWWRANLVLVLMSHSYVWCEGETNPKKVLPKSLAIPLVGVSEHLGMPPILTHYCYAIYNWRVIDISRPLTLDNIKPI-NTFTGTPSEDGFITVAVQVEMEFGKSVTSLIASQKAVLSDDCQLLRKELFSVQQMISRLTNALLKIHDVCKPRDFYCFIRVFLNGWQSTS-ALPEGLIYEGV--SSTPRQYPGGSAAESTVFQVLDAFLGIRHHSPSRTSFLKLMRKHMPPKHNEFITAVENGPSVRHYVEN-SKDQRLHEQYNACVTALQEYRNAHLSIVTKYIIIQANKDPENPNRRLA 366          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Medaka
Match: ido1 (indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Acc:101167965])

HSP 1 Score: 158.303 bits (399), Expect = 2.737e-43
Identity = 109/364 (29.95%), Postives = 186/364 (51.10%), Query Frame = 3
Query:   54 FSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFN-EMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQD 1142
               Y V  + GFL+ +  + EL  +Y PW++I  ++  L++++ LR  I KMP+LS E L + ++    H +L+  T  YVW + + +  + LP +L+VPL  +S  LGL PIL H+D VL N    + K   + +L ++ N    +     F   T  +E    P I+ I  + + +    T  V+  L+ IS ++  M +++K  +  ++P  F+  MR FL GW  D  +   GL+YE       E    GGSAAQS      D L  I+H   S  F + M+ YM   H+  I+D+     L++F+++ +    L + ++ C++ +   R  H+ VV++FI  P+ +  +    S+ L+D
Sbjct:   13 LGPYQVSEDCGFLLKEPLQ-ELPPHYQPWMDIARHIPELVQSHELRSEIYKMPMLSSEFLQNEKELRLAHLVLSMMTMGYVWQEGEKDTVETLPCNLAVPLWNVSQSLGLPPILTHADGVLAN----WMKKDPEGNLELLINLPGGDSVRGFF-LVTLLVEVAAVPAIKNIPVVINGVRCGDTNAVVQALENISQSIQDMTDALKLMHVYVDPSVFYGIMRIFLSGW-KDNPSMPKGLIYEGVQKEPMEYS--GGSAAQSSLLHCFDELLGIKHEESSSSFLNRMRDYMPPAHKQLIQDISYQPSLKSFVQQQNCGH-LKQTYHLCVSKLLALRNYHITVVSRFITVPAARTRQLRKQSQDLED 366          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Medaka
Match: ENSORLT00000007240.2 (indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Acc:101169805])

HSP 1 Score: 157.532 bits (397), Expect = 6.990e-43
Identity = 115/361 (31.86%), Postives = 173/361 (47.92%), Query Frame = 3
Query:   51 EFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIR-----AIYNLYDCIINEKTEEVIS---NLKVISLTLTSMRESMK-NFNEMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATE-IECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            +F  + +    GF++ +   T L  YY  W+++  NL  L+E++ LR+ + KMPVLS   LTS  +    H  L F T  YVW + Q    +ILPK+L+ P   +S +LGL PIL ++D VL N  +        KD        N ++ ++    ET R  F  S ++       I    + +   K  +++     L  ++ +L  M+E+ +   N +    FH  +R F+ GW  D      GLLYE   G +TE I   GGSAAQS   Q  D L  IQH  ++  F   M+ YM+  HR  I  +     L  FI   S    L +A+N C++A+   R  H+  V K++I P  K
Sbjct:   19 DFDAFDISEEFGFILEE-PLTHLPEYYQVWMDLANNLAHLIESHKLRDLVHKMPVLSPHHLTSHRELRLAHLALGFITMGYVWQEGQHAPAQILPKALAWPYWMVSCRLGLPPILTYADSVLANWKL--------KDPTGDMEIGNMDLMFSFPGGETCRGFFMVSLLVEMAASSGIAGALEVMHAMKISDLVGIQKGLIRVTQSLKKMKETFQLMHNHVEATAFHGTLRIFVSGW-RDNPMLPRGLLYE---GVSTEPIFLSGGSAAQSSAIQCFDALLCIQHEGEAGAFLTRMRDYMLPPHRQLIETLSVCSSLRDFITACSSSD-LCQAYNSCVSALVDLRNYHLNTVAKYVIVPGNK 365          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Medaka
Match: ido1 (indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Acc:101167965])

HSP 1 Score: 157.147 bits (396), Expect = 8.700e-43
Identity = 110/365 (30.14%), Postives = 186/365 (50.96%), Query Frame = 3
Query:   54 FSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFN-EMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQD 1142
               Y V  + GFL+ +  + EL  +Y PW++I  ++  L++++ LR  I KMP+LS E L + ++    H +L+  T  YVW + + +  + LP +L+VPL  +S  LGL PIL H+D VL N    D     S ++L ++ N    +     F   T  +E    P I+ I  + + +    T  V+  L+ IS ++  M +++K  +  ++P  F+  MR FL GW  D  +   GL+YE       E    GGSAAQS      D L  I+H   S  F + M+ YM   H+  I+D+     L++F+++ +    L + ++ C++ +   R  H+ VV++FI  P+ +  +    S+ L+D
Sbjct:   13 LGPYQVSEDCGFLLKEPLQ-ELPPHYQPWMDIARHIPELVQSHELRSEIYKMPMLSSEFLQNEKELRLAHLVLSMMTMGYVWQEGEKDTVETLPCNLAVPLWNVSQSLGLPPILTHADGVLANWMKKDPEGPFSMENLELLINLPGGDSVRGFF-LVTLLVEVAAVPAIKNIPVVINGVRCGDTNAVVQALENISQSIQDMTDALKLMHVYVDPSVFYGIMRIFLSGW-KDNPSMPKGLIYEGVQKEPMEYS--GGSAAQSSLLHCFDELLGIKHEESSSSFLNRMRDYMPPAHKQLIQDISYQPSLKSFVQQQNCGH-LKQTYHLCVSKLLALRNYHITVVSRFITVPAARTRQLRKQSQDLED 371          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Medaka
Match: ido1 (indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Acc:101167965])

HSP 1 Score: 157.147 bits (396), Expect = 8.830e-43
Identity = 110/362 (30.39%), Postives = 186/362 (51.38%), Query Frame = 3
Query:   63 YFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFN-TYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFN-EMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQD 1142
            Y V  + GFL+ +  + EL  +Y PW++I  ++  L++++ LR  I KMP+LS E L + ++    H +L+  T  YVW + + +  + LP +L+VPL  +S  LGL PIL H+D VL N    D     S ++L ++ N    +     F   T  +E    P I+ I  + + +    T  V+  L+ IS ++  M +++K  +  ++P  F+  MR FL GW  D  +   GL+YE       E    GGSAAQS      D L  I+H   S  F + M+ YM   H+  I+D+     L++F+++ +    L + ++ C++ +   R  H+ VV++FI  P+ +  +    S+ L+D
Sbjct:   25 YQVSEDCGFLLKEPLQ-ELPPHYQPWMDIARHIPELVQSHELRSEIYKMPMLSSEFLQNEKELRLAHLVLSMMTMGYVWQEGEKDTVETLPCNLAVPLWNVSQSLGLPPILTHADGVLANWMKKDPEGPFSMENLELLINLPGGDSVRGFF-LVTLLVEVAAVPAIKNIPVVINGVRCGDTNAVVQALENISQSIQDMTDALKLMHVYVDPSVFYGIMRIFLSGW-KDNPSMPKGLIYEGVQKEPMEYS--GGSAAQSSLLHCFDELLGIKHEESSSSFLNRMRDYMPPAHKQLIQDISYQPSLKSFVQQQNCGH-LKQTYHLCVSKLLALRNYHITVVSRFITVPAARTRQLRKQSQDLED 380          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Medaka
Match: ENSORLT00000041280.1 (indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Acc:101169805])

HSP 1 Score: 129.028 bits (323), Expect = 8.485e-33
Identity = 100/309 (32.36%), Postives = 144/309 (46.60%), Query Frame = 3
Query:  207 MPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIR-----AIYNLYDCIINEKTEEVIS---NLKVISLTLTSMRESMKNF-NEMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATE-IECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKK 1103
            MPVLS   LTS  +    H  L F T  YVW + Q    +ILPK+L+ P   +S +LGL PIL ++D VL N  +        KD        N ++ ++    ET R  F  S ++       I    + +   K  +++     L  ++ +L  M+E+ +   N +    FH  +R F+ GW  D      GLLYE   G +TE I   GGSAAQS   Q  D L  IQH  ++  F   M+ YM+  HR  I  +     L  FI   S    L +A+N C++A+   R  H+  V K++I P  K
Sbjct:   38 MPVLSPHHLTSHRELRLAHLALGFITMGYVWQEGQHAPAQILPKALAWPYWMVSCRLGLPPILTYADSVLANWKL--------KDPTGDMEIGNMDLMFSFPGGETCRGFFMVSLLVEMAASSGIAGALEVMHAMKISDLVGIQKGLIRVTQSLKKMKETFQLMHNHVEATAFHGTLRIFVSGW-RDNPMLPRGLLYE---GVSTEPIFLSGGSAAQSSAIQCFDALLCIQHEGEAGAFLTRMRDYMLPPHRQLIETLSVCSSLRDFITACSSSD-LCQAYNSCVSALVDLRNYHLNTVAKYVIVPGNK 333          
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Planmine SMEST
Match: SMESG000058473.1 (SMESG000058473.1)

HSP 1 Score: 763.451 bits (1970), Expect = 0.000e+0
Identity = 367/367 (100.00%), Postives = 367/367 (100.00%), Query Frame = 3
Query:   45 MLEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNEMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQDR 1145
            MLEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNEMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQDR
Sbjct:    1 MLEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLREYIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSLSVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKNINWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTLTSMRESMKNFNEMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSATEIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIRDVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINPSKKMVKEEINSEFLQDR 367          
The following BLAST results are available for this feature:
BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
IDO27.700e-5231.83indoleamine 2,3-dioxygenase 2 [Source:HGNC Symbol;... [more]
IDO21.374e-5131.83indoleamine 2,3-dioxygenase 2 [Source:HGNC Symbol;... [more]
IDO12.675e-4329.95indoleamine 2,3-dioxygenase 1 [Source:HGNC Symbol;... [more]
IDO12.675e-4329.95indoleamine 2,3-dioxygenase 1 [Source:HGNC Symbol;... [more]
IDO12.969e-1937.19indoleamine 2,3-dioxygenase 1 [Source:HGNC Symbol;... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ido11.550e-4930.19indoleamine 2,3-dioxygenase 1 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Ido21.238e-4630.36indoleamine 2,3-dioxygenase 2 [Source:MGI Symbol;A... [more]
Ido15.263e-4630.41indoleamine 2,3-dioxygenase 1 [Source:MGI Symbol;A... [more]
Ido14.826e-3130.31indoleamine 2,3-dioxygenase 1 [Source:MGI Symbol;A... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q01966|MYG_HALDV1.161e-5330.88Myoglobin OS=Haliotis diversicolor OX=36095 PE=1 S... [more]
sp|P51537|MYG_HALMK1.941e-5331.73Myoglobin OS=Haliotis madaka OX=81897 PE=2 SV=2[more]
sp|Q6ZQW0|I23O2_HUMAN6.597e-5131.83Indoleamine 2,3-dioxygenase 2 OS=Homo sapiens OX=9... [more]
sp|Q9ERD9|I23O1_RAT6.281e-4830.99Indoleamine 2,3-dioxygenase 1 OS=Rattus norvegicus... [more]
sp|Q8R0V5|I23O2_MOUSE8.658e-4630.36Indoleamine 2,3-dioxygenase 2 OS=Mus musculus OX=1... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
Q6F3I37.235e-5931.84Molluscan indoleamine 2,3-dioxygenase like protein... [more]
Q6F3I45.752e-5832.12Molluscan indoleamine 2,3-dioxygenase like protein... [more]
A0A5F4WIH15.306e-5332.86Indoleamine 2,3-dioxygenase 2 OS=Callithrix jacchu... [more]
A0A4E0R3458.592e-5329.17Uncharacterized protein OS=Fasciola hepatica OX=61... [more]
G1RPS91.413e-5231.83Indoleamine 2,3-dioxygenase 2 OS=Nomascus leucogen... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ido16.409e-5032.02indoleamine 2,3-dioxygenase 2-like [Source:NCBI ge... [more]
ido16.783e-5032.75indoleamine 2,3-dioxygenase 2-like [Source:NCBI ge... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ido14.764e-3729.56indoleamine 2,3-dioxygenase 1 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
BNA21.352e-3628.80Tryptophan 2,3-dioxygenase or indoleamine 2,3-diox... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO380597.308e-4027.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ido12.737e-4329.95indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Ac... [more]
ENSORLT00000007240.26.990e-4331.86indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Ac... [more]
ido18.700e-4330.14indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Ac... [more]
ido18.830e-4330.39indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Ac... [more]
ENSORLT00000041280.18.485e-3332.36indoleamine 2,3-dioxygenase 2 [Source:NCBI gene;Ac... [more]
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BLAST of Indoleamine 2,3-dioxygenase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000058473.10.000e+0100.00SMESG000058473.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034259 ID=SMED30034259|Name=Indoleamine 2,3-dioxygenase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1410bp
TATCTGAATCGAATTTTAACGGTGGATAAATAATCATAATTTCAATGCTT
GAATTCTCAGATTATTTCGTCGATTTTAATACTGGATTTCTTATCAATCA
AAATCAAAAGACTGAACTATCTAGCTATTATGATCCTTGGATAAATATAC
AGGTTAATTTGGGCAGTTTGATGGAGACGAACAATTTGAGAGAATATATT
GATAAGATGCCAGTGCTAAGCATTGAACTATTAACGTCATTTGAACAAAA
TTTTTATTGTCATAGTATACTGGCATTTGCGACATCAGCATACGTATGGA
GCAAACAACAAGCTGAAATCCCTAAAATTTTACCGAAATCGTTATCGGTT
CCGTTACGTAAACTTTCGGATAAACTTGGACTAATGCCGATATTGTGCCA
TTCGGATATGGTTCTTTTCAATACTTACGTCGATTTCACCAAATCTGTGT
CGGACAAAGATTTATTGGTCATAAAAAATTCAATGAATAAAAATATAAAT
TGGAATATATTTCAAAGAGAAACTGCAAGAATTGAGTTTTGTTTTAGTCC
AATAATACGAGCAATATACAATCTTTATGATTGTATTATAAATGAAAAAA
CTGAGGAAGTGATTTCCAATCTAAAAGTCATTTCTCTCACGTTGACCTCC
ATGAGAGAATCCATGAAAAACTTTAATGAAATGAATCCTGATTATTTTCA
TAGAGAAATGAGACCATTTTTATTGGGATGGGGTGGAGATGGTTATGCTC
ACCAAGGAGGGTTATTGTATGAAAATGAAGATGGATCAGCAACAGAAATC
GAATGCATCGGTGGTAGTGCAGCACAGAGTCCAACTTCACAAGTTCTTGA
TACGTTATTCAAAATTCAACATTCAGCTAAATCACAGAAATTTTTCGACT
CTATGAAACTCTATATGATTAAAGAACATAGAAATTTTATACGCGATGTC
GACACATTCATAGATCTCGAGGCTTTCATTCGAAAGTACTCTAAAGATCA
ACTTCTTATTGAAGCTCACAATGAATGCATAAATGCAATTTCAATTTACC
GGACAAATCATATGCAAGTTGTTACAAAATTTATTATAAATCCTTCGAAA
AAAATGGTTAAAGAAGAAATTAATTCTGAATTCTTACAAGATCGAGGAAC
TGGCGGACAAGAAATCTCGTCCACCAGCATATCTTCCCCAGAAACGGGCA
TCACTCCCAGAAATGTAGGTCTTATCCACAGAAATGTGGGCATCTCCAGA
AACAGAGACATATTCAGGAACAATGGCATCCCCAGAAACGGGTGCATCAT
CAGGAACATTATTTTCTTCATCTAAAAAATTCATAATAATTTAAAAAATT
AAATAAATTTACCATCGTCGATAACTATGACTTCCATCGGTGTATCGCTT
ATTATAATTA
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protein sequence of SMED30034259-orf-1

>SMED30034259-orf-1 ID=SMED30034259-orf-1|Name=SMED30034259-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=427bp
MLEFSDYFVDFNTGFLINQNQKTELSSYYDPWINIQVNLGSLMETNNLRE
YIDKMPVLSIELLTSFEQNFYCHSILAFATSAYVWSKQQAEIPKILPKSL
SVPLRKLSDKLGLMPILCHSDMVLFNTYVDFTKSVSDKDLLVIKNSMNKN
INWNIFQRETARIEFCFSPIIRAIYNLYDCIINEKTEEVISNLKVISLTL
TSMRESMKNFNEMNPDYFHREMRPFLLGWGGDGYAHQGGLLYENEDGSAT
EIECIGGSAAQSPTSQVLDTLFKIQHSAKSQKFFDSMKLYMIKEHRNFIR
DVDTFIDLEAFIRKYSKDQLLIEAHNECINAISIYRTNHMQVVTKFIINP
SKKMVKEEINSEFLQDRGTGGQEISSTSISSPETGITPRNVGLIHRNVGI
SRNRDIFRNNGIPRNGCIIRNIIFFI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0002534cytokine production involved in inflammatory response
GO:0002666positive regulation of T cell tolerance induction
GO:0002678positive regulation of chronic inflammatory response
GO:0002830positive regulation of type 2 immune response
GO:0006954inflammatory response
GO:0032496response to lipopolysaccharide
GO:0032693negative regulation of interleukin-10 production
GO:0032735positive regulation of interleukin-12 production
GO:0033555multicellular organismal response to stress
GO:0034276kynurenic acid biosynthetic process
GO:0036269swimming behavior
GO:0042130negative regulation of T cell proliferation
GO:0043065positive regulation of apoptotic process
GO:0046007negative regulation of activated T cell proliferation
GO:0070233negative regulation of T cell apoptotic process
GO:0070234positive regulation of T cell apoptotic process
GO:0002376immune system process
GO:0006569tryptophan catabolic process
GO:0019441tryptophan catabolic process to kynurenine
GO:0055114oxidation-reduction process
Vocabulary: cellular component
TermDefinition
GO:0030485smooth muscle contractile fiber
GO:0032421stereocilium bundle
GO:0005737cytoplasm
GO:0005829cytosol
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002075pigment cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR037217Trp/Indoleamine_2_3_dOase-like
IPR000898Indolamine_dOase
Vocabulary: molecular function
TermDefinition
GO:0020037heme binding
GO:0004833tryptophan 2,3-dioxygenase activity
GO:0016491oxidoreductase activity
GO:0033754indoleamine 2,3-dioxygenase activity
GO:0046872metal ion binding
GO:0051213dioxygenase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:1.20.58.480coord: 126..377
e-value: 6.0E-36
score: 126.0
IPR000898Indoleamine 2,3-dioxygenasePFAMPF01231IDOcoord: 5..361
e-value: 1.9E-73
score: 247.7
IPR000898Indoleamine 2,3-dioxygenasePANTHERPTHR28657FAMILY NOT NAMEDcoord: 5..374
IPR037217Tryptophan/Indoleamine 2,3-dioxygenase-likeSUPERFAMILYSSF140959Indolic compounds 2,3-dioxygenase-likecoord: 5..373