Dual specificity tyrosine-phosphorylation-regulated kinase 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30034243 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 606.675 bits (1563), Expect = 0.000e+0 Identity = 286/411 (69.59%), Postives = 337/411 (82.00%), Query Frame = 1
Query: 583 DPLKRETDSSSKMKTSVNM----STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
D + R SS+ +K+ M +T ++P+ AM+Q+M KLT +EHHEIFSYP I+F+G NAKKR G+ GG NN GYDDDQ SY+ V HDH+AYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGSV+L GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 128 DSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 604.364 bits (1557), Expect = 0.000e+0 Identity = 286/411 (69.59%), Postives = 337/411 (82.00%), Query Frame = 1
Query: 583 DPLKRETDSSSKMKTSVNM----STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
D + R SS+ +K+ M +T ++P+ AM+Q+M KLT +EHHEIFSYP I+F+G NAKKR G+ GG NN GYDDDQ SY+ V HDH+AYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGSV+L GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 55 DSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 465
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 543.502 bits (1399), Expect = 0.000e+0 Identity = 269/416 (64.66%), Postives = 319/416 (76.68%), Query Frame = 1
Query: 598 ETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSN 1845
+++SSSK V L+P+ A++Q+ LT YE EI +YP I+FVG NAKKR GV+GG NN GYDD +YIHV DH+AYRYEVLK++GKGSFGQV + DHK + VA+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNHVCM FELLSI+LYELIKKNKFQGFS+QLVRKFA SIL L+ L++NKIIHCDLKPENILLK GRS KVIDFGSSC E+Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL TG P+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ PRYC +T ADG V+L GGRS+RG+ RGPP SK TALK CDD LF++F RCL W P R+TP +AL+HPW+ K +P T K S
Sbjct: 128 KSNSSSKAPKVVP----LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-SKSVPRPLTTIDKVSG 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 542.732 bits (1397), Expect = 0.000e+0 Identity = 269/416 (64.66%), Postives = 319/416 (76.68%), Query Frame = 1
Query: 598 ETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSN 1845
+++SSSK V L+P+ A++Q+ LT YE EI +YP I+FVG NAKKR GV+GG NN GYDD +YIHV DH+AYRYEVLK++GKGSFGQV + DHK + VA+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNHVCM FELLSI+LYELIKKNKFQGFS+QLVRKFA SIL L+ L++NKIIHCDLKPENILLK GRS KVIDFGSSC E+Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL TG P+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ PRYC +T ADG V+L GGRS+RG+ RGPP SK TALK CDD LF++F RCL W P R+TP +AL+HPW+ K +P T K S
Sbjct: 108 KSNSSSKAPKVVP----LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-SKSVPRPLTTIDKVSG 518
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 542.732 bits (1397), Expect = 0.000e+0 Identity = 269/416 (64.66%), Postives = 319/416 (76.68%), Query Frame = 1
Query: 598 ETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSN 1845
+++SSSK V L+P+ A++Q+ LT YE EI +YP I+FVG NAKKR GV+GG NN GYDD +YIHV DH+AYRYEVLK++GKGSFGQV + DHK + VA+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNHVCM FELLSI+LYELIKKNKFQGFS+QLVRKFA SIL L+ L++NKIIHCDLKPENILLK GRS KVIDFGSSC E+Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL TG P+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ PRYC +T ADG V+L GGRS+RG+ RGPP SK TALK CDD LF++F RCL W P R+TP +AL+HPW+ K +P T K S
Sbjct: 108 KSNSSSKAPKVVP----LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-SKSVPRPLTTIDKVSG 518
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 567 bits (1460), Expect = 0.000e+0 Identity = 266/383 (69.45%), Postives = 318/383 (83.03%), Query Frame = 1
Query: 655 PDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
P+ A++ F +KL +E +EI++Y +FFVG++AKK+AGV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPPAS++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 395 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 777
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0 Identity = 266/383 (69.45%), Postives = 318/383 (83.03%), Query Frame = 1
Query: 655 PDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
P+ A++ F +KL +E +EI++Y +FFVG++AKK+AGV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPPAS++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 378 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 760
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0 Identity = 266/383 (69.45%), Postives = 318/383 (83.03%), Query Frame = 1
Query: 655 PDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
P+ A++ F +KL +E +EI++Y +FFVG++AKK+AGV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPPAS++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 395 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 777
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0 Identity = 266/383 (69.45%), Postives = 318/383 (83.03%), Query Frame = 1
Query: 655 PDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
P+ A++ F +KL +E +EI++Y +FFVG++AKK+AGV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPPAS++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 378 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 760
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 561.222 bits (1445), Expect = 0.000e+0 Identity = 266/388 (68.56%), Postives = 320/388 (82.47%), Query Frame = 1
Query: 640 STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
++ P+ A++ F +KL +E +EI++Y +FFVG++AKK+AGV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPPAS++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 108 NSGFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100406) HSP 1 Score: 521.161 bits (1341), Expect = 1.453e-172 Identity = 256/385 (66.49%), Postives = 307/385 (79.74%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
+SP M +M+KLT YE EI +YP I+F+G NAKKR GV G NN YD++Q +YIHV HDH+AYRYE+LK++GKGSFGQV+KA DHKT E VA+K+VRNEKRF RQA EEIR+L L++ D + N+IH+ D F FRNH C+TFELLSINLYELIKKN F+GFSLQLVRKFA+S+L CL+ LY+N IIHCD+KPEN+LLKQQGRSGIKVIDFGSSC E+QRIYTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL +G+ +FPGE+E DQLACI+E+LG P + KR+K FF+ + YPRYC T +DG V+L GG+S+RG+ RGPP SK+LS AL C D LFL+F CL W + R+TP EALKHPWLRR+
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYG-PNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRR 592
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100404) HSP 1 Score: 521.161 bits (1341), Expect = 1.453e-172 Identity = 256/385 (66.49%), Postives = 307/385 (79.74%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
+SP M +M+KLT YE EI +YP I+F+G NAKKR GV G NN YD++Q +YIHV HDH+AYRYE+LK++GKGSFGQV+KA DHKT E VA+K+VRNEKRF RQA EEIR+L L++ D + N+IH+ D F FRNH C+TFELLSINLYELIKKN F+GFSLQLVRKFA+S+L CL+ LY+N IIHCD+KPEN+LLKQQGRSGIKVIDFGSSC E+QRIYTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL +G+ +FPGE+E DQLACI+E+LG P + KR+K FF+ + YPRYC T +DG V+L GG+S+RG+ RGPP SK+LS AL C D LFL+F CL W + R+TP EALKHPWLRR+
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYG-PNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRR 592
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100402) HSP 1 Score: 521.161 bits (1341), Expect = 1.453e-172 Identity = 256/385 (66.49%), Postives = 307/385 (79.74%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
+SP M +M+KLT YE EI +YP I+F+G NAKKR GV G NN YD++Q +YIHV HDH+AYRYE+LK++GKGSFGQV+KA DHKT E VA+K+VRNEKRF RQA EEIR+L L++ D + N+IH+ D F FRNH C+TFELLSINLYELIKKN F+GFSLQLVRKFA+S+L CL+ LY+N IIHCD+KPEN+LLKQQGRSGIKVIDFGSSC E+QRIYTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL +G+ +FPGE+E DQLACI+E+LG P + KR+K FF+ + YPRYC T +DG V+L GG+S+RG+ RGPP SK+LS AL C D LFL+F CL W + R+TP EALKHPWLRR+
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYG-PNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRR 592
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0100447) HSP 1 Score: 426.787 bits (1096), Expect = 1.548e-137 Identity = 204/388 (52.58%), Postives = 272/388 (70.10%), Query Frame = 1
Query: 643 TCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKK---RAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLR 1797
T ++P +++F + LT E E+ Y +++ G +A K + T N GYDDD +Y + HDHIA+RYE+L+++GKGSFGQV++ALDHKT VAIK++RN+KRF QA E+ +L+ L+++D D + NVIH++D FR H+C+TFEL+S+NLYELIKKN + GFS+ L+R+F SI+ CL LLY+ IIHCDLKPENILLKQ+G S IKVIDFGSSC ++IYTYIQSRFYR+PEVILG +YG IDMWS GCILAELYTG+P+FPGE+E +QLACIME+LG PP L + +R ++FF S+ PR C+ +T + P SK+L+ L +C D+ F+DF RCL W P RMTP EA H +L+
Sbjct: 125 TPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPR-CITNTKG---------------RKRSPGSKSLAHIL-HCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089289) HSP 1 Score: 426.787 bits (1096), Expect = 1.548e-137 Identity = 204/388 (52.58%), Postives = 272/388 (70.10%), Query Frame = 1
Query: 643 TCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKK---RAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLR 1797
T ++P +++F + LT E E+ Y +++ G +A K + T N GYDDD +Y + HDHIA+RYE+L+++GKGSFGQV++ALDHKT VAIK++RN+KRF QA E+ +L+ L+++D D + NVIH++D FR H+C+TFEL+S+NLYELIKKN + GFS+ L+R+F SI+ CL LLY+ IIHCDLKPENILLKQ+G S IKVIDFGSSC ++IYTYIQSRFYR+PEVILG +YG IDMWS GCILAELYTG+P+FPGE+E +QLACIME+LG PP L + +R ++FF S+ PR C+ +T + P SK+L+ L +C D+ F+DF RCL W P RMTP EA H +L+
Sbjct: 125 TPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPR-CITNTKG---------------RKRSPGSKSLAHIL-HCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 577.785 bits (1488), Expect = 0.000e+0 Identity = 299/486 (61.52%), Postives = 358/486 (73.66%), Query Frame = 1
Query: 427 VENFNSFTVTQMFEENRQQTN------NHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPL---KRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 1857
V N V Q+FEEN + N P+ + + +P+ + + ++ + +S K S L+P+ AM+Q+MSKL+ +EH EI SY I+F+G NAKKR GV+GG+NN GYDDDQ SYIHV HDHIAYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD DS NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CLE L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL + KR K F +S+ +PRYC +T D SV+L GGRS+RG+ RGPP S+ TALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+ +P KT +G
Sbjct: 72 VGNHQQIHVQQLFEENSNKRTVLTSQPNGLTPVGRAG--------------LAMPEKQQEISQCRQGSSTSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRR-LPKPPTEKTTVKRITEG 542
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 577.4 bits (1487), Expect = 0.000e+0 Identity = 299/486 (61.52%), Postives = 358/486 (73.66%), Query Frame = 1
Query: 427 VENFNSFTVTQMFEENRQQTN------NHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPL---KRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 1857
V N V Q+FEEN + N P+ + + +P+ + + ++ + +S K S L+P+ AM+Q+MSKL+ +EH EI SY I+F+G NAKKR GV+GG+NN GYDDDQ SYIHV HDHIAYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD DS NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CLE L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL + KR K F +S+ +PRYC +T D SV+L GGRS+RG+ RGPP S+ TALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+ +P KT +G
Sbjct: 62 VGNHQQIHVQQLFEENSNKRTVLTSQPNGLTPVGRAG--------------LAMPEKQQEISQCRQGSSTSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRR-LPKPPTEKTTVKRITEG 532
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 576.63 bits (1485), Expect = 0.000e+0 Identity = 299/486 (61.52%), Postives = 358/486 (73.66%), Query Frame = 1
Query: 427 VENFNSFTVTQMFEENRQQTN------NHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPL---KRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 1857
V N V Q+FEEN + N P+ + + +P+ + + ++ + +S K S L+P+ AM+Q+MSKL+ +EH EI SY I+F+G NAKKR GV+GG+NN GYDDDQ SYIHV HDHIAYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD DS NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CLE L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL + KR K F +S+ +PRYC +T D SV+L GGRS+RG+ RGPP S+ TALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+ +P KT +G
Sbjct: 83 VGNHQQIHVQQLFEENSNKRTVLTSQPNGLTPVGRAG--------------LAMPEKQQEISQCRQGSSTSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRR-LPKPPTEKTTVKRITEG 553
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 568.155 bits (1463), Expect = 0.000e+0 Identity = 268/400 (67.00%), Postives = 322/400 (80.50%), Query Frame = 1
Query: 637 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRR---KQIPGNSIT 1827
+ + ++P+ A++Q ++TT E EI +Y I+F+G NAKKR V GGTNN GYDDDQ YIHV HDH+AYRYE LK++GKGSFGQV K DHK + VA+K+VRNEKRF RQAAEEIR+LE LKKQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L+R+KIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCILAEL TGYP+FPGEDEGDQLAC+ME+LG PP+KL + KR K F +S+ +PRYC ST ++G+++L G RS+RG+ RG P SK TALK C+D F+DF +CL W P TRMTP +AL+HPWL + K PG T
Sbjct: 128 LGSPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVSTLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLPKPAPGGEKT 527
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 568.155 bits (1463), Expect = 0.000e+0 Identity = 268/400 (67.00%), Postives = 322/400 (80.50%), Query Frame = 1
Query: 637 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRR---KQIPGNSIT 1827
+ + ++P+ A++Q ++TT E EI +Y I+F+G NAKKR V GGTNN GYDDDQ YIHV HDH+AYRYE LK++GKGSFGQV K DHK + VA+K+VRNEKRF RQAAEEIR+LE LKKQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L+R+KIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCILAEL TGYP+FPGEDEGDQLAC+ME+LG PP+KL + KR K F +S+ +PRYC ST ++G+++L G RS+RG+ RG P SK TALK C+D F+DF +CL W P TRMTP +AL+HPWL + K PG T
Sbjct: 129 LGSPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVSTLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLPKPAPGGEKT 528
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:100485120]) HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0 Identity = 298/463 (64.36%), Postives = 361/463 (77.97%), Query Frame = 1
Query: 427 VENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNM----STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
V + V Q+FEEN + + + + N + ++ ++E +R+ SSS +K++ + S+ L+P+ AM+Q+M KLT +EHHEIF+YP I+F+G NAKKR GV+GG NN GYDDDQ SY+ V HDH+AYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE LKKQD D+N NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILGG+YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K FF+S+ YPRYC ++ DGSV+L GGRS+RG+ RGPP S+ TALK CDD LFLDF +CL W P RMTP +AL+H WLRR+
Sbjct: 106 VTSHGQIQVQQLFEENSNK-----RTVLTTQPNGLTTVGKSTLPVVSERQLESTHRRQ-GSSSSLKSAEGITKLKSSSLTPEQAMKQYMQKLTAFEHHEIFNYPEIYFLGPNAKKRQGVIGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRR 562
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 548.125 bits (1411), Expect = 0.000e+0 Identity = 273/406 (67.24%), Postives = 321/406 (79.06%), Query Frame = 1
Query: 643 TCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGK 1860
T L+PD A++Q+ +L+ YE EI S+ I+FVG NAKKR GV+GG NN GYDDDQ Y V HDH+AYRYEVLK++GKGSFGQV K DHK + +A+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSLQLVRKFA+SIL CLE LYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCIL EL TGYP+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ YPRYC +T +G+ +L G RS+RG+ RG P SK ALK C+D LF+DF CLTW P RMTP +AL+H W+ K++P S+T+ I +
Sbjct: 98 TYLTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI-SKRLPKPSVTEKASGKRISSQ 502
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 547.74 bits (1410), Expect = 0.000e+0 Identity = 273/403 (67.74%), Postives = 320/403 (79.40%), Query Frame = 1
Query: 643 TCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNI 1851
T L+PD A++Q+ +L+ YE EI S+ I+FVG NAKKR GV+GG NN GYDDDQ Y V HDH+AYRYEVLK++GKGSFGQV K DHK + +A+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSLQLVRKFA+SIL CLE LYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCIL EL TGYP+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ YPRYC +T +G+ +L G RS+RG+ RG P SK ALK C+D LF+DF CLTW P RMTP +AL+H W+ K++P S+T+ I
Sbjct: 120 TYLTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI-SKRLPKPSVTEKASGKRI 521
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 546.969 bits (1408), Expect = 0.000e+0 Identity = 273/406 (67.24%), Postives = 321/406 (79.06%), Query Frame = 1
Query: 643 TCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGK 1860
T L+PD A++Q+ +L+ YE EI S+ I+FVG NAKKR GV+GG NN GYDDDQ Y V HDH+AYRYEVLK++GKGSFGQV K DHK + +A+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSLQLVRKFA+SIL CLE LYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCIL EL TGYP+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ YPRYC +T +G+ +L G RS+RG+ RG P SK ALK C+D LF+DF CLTW P RMTP +AL+H W+ K++P S+T+ I +
Sbjct: 91 TYLTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI-SKRLPKPSVTEKASGKRISSQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 546.584 bits (1407), Expect = 0.000e+0 Identity = 273/406 (67.24%), Postives = 321/406 (79.06%), Query Frame = 1
Query: 643 TCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGK 1860
T L+PD A++Q+ +L+ YE EI S+ I+FVG NAKKR GV+GG NN GYDDDQ Y V HDH+AYRYEVLK++GKGSFGQV K DHK + +A+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSLQLVRKFA+SIL CLE LYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCIL EL TGYP+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ YPRYC +T +G+ +L G RS+RG+ RG P SK ALK C+D LF+DF CLTW P RMTP +AL+H W+ K++P S+T+ I +
Sbjct: 81 TYLTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI-SKRLPKPSVTEKASGKRISSQ 485
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:MGI Symbol;Acc:MGI:1330301]) HSP 1 Score: 601.282 bits (1549), Expect = 0.000e+0 Identity = 283/409 (69.19%), Postives = 335/409 (81.91%), Query Frame = 1
Query: 589 LKRETDSSSKMKTSVNM----STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
+ R SS+ +K+ M ++ ++P+ AM+Q+M KLT +EHHEIFSYP I+F+G NAKKR G+ GG NN GYDDDQ SY+ V HDH+AYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRS IKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGSV+L GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 128 IHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 536
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:MGI Symbol;Acc:MGI:1330300]) HSP 1 Score: 541.576 bits (1394), Expect = 0.000e+0 Identity = 269/450 (59.78%), Postives = 327/450 (72.67%), Query Frame = 1
Query: 520 GNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMST------CLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK--------QIPGNSIT 1827
GN+ N + ++ I + P + S S N+S+ L+P+ A++Q+ LT YE EI SYP I+FVG NAKKR GV+GG NN GYDD +YIHV DH+AYRYEVLK++GKGSFGQV + DHK + VA+KMVRNEKRF RQAAEEIR+LE LKKQD + NVIH+++ F FRNHVCM FELLSI+LYELIKKNKFQGFS+QLVRKFA SIL L+ L++NKIIHCDLKPENILLK GRS KVIDFGSSC E+Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL TG P+FPGEDEGDQLAC++E+LG PP KL + KR K F S+ PRYC ST DG V+L GGRS+RG+ RGPP SK +TALK C D LF++F RCL W P R+TP +AL+HPW+ + ++PG +
Sbjct: 93 GNRRSNTLQSDG--ISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTMDKVPGKRVV 540
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:MGI Symbol;Acc:MGI:1330292]) HSP 1 Score: 438.343 bits (1126), Expect = 7.376e-143 Identity = 207/382 (54.19%), Postives = 267/382 (69.90%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
L+ A++ F ++L+ YE EI Y ++F+G AKK V + +DD+ SY+ V HDHIAYRYEVL+++GKGSFGQV K LDHK E VA+K++RN+KRF QA E+++LE L+++D D+N NV+H+ D F FRNH+C+TFELL INLYEL+K N F GF+L +VR+F +SIL CL +LY KIIHCDLKPENI+L Q+G+ +KVIDFGSSC EHQ++YTYIQSRFYR+PEVILG Y M IDMWS GCI+AELYTGYP+FPGE+E +QLACIME+LG PP T R ++FF S+ P+ + + G P SK L+ +K D FLDF RCL W P RMTP++ALKH W+
Sbjct: 151 LTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNI--NNNRGGKRY--------------PDSKDLTMVVKTYDSS-FLDFLRRCLVWEPSLRMTPEQALKHAWI 515
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 295.434 bits (755), Expect = 1.134e-88 Identity = 160/361 (44.32%), Postives = 216/361 (59.83%), Query Frame = 1
Query: 745 TNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRN----KIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQST-----DADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRR 1800
++ KK VL N GYDDD + YI + + RYE+ L+GKGSFGQVVKA DH+T E VAIK+++N+K F QA E+RLLEL+ + D + ++H+ F+FRNH+C+ FELLS NLY+L++ F+G SL L RK A LC LL+ IIHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG Y + IDMWS GCIL E++TG P+F G +E DQ++ I+E+LG PP + + + + +F + ++ T D G + + GP + D F D LR L + P R++P AL+H + RR
Sbjct: 79 SSTKKEKKVL----NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ--LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRR 433
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 295.049 bits (754), Expect = 8.636e-88 Identity = 160/361 (44.32%), Postives = 216/361 (59.83%), Query Frame = 1
Query: 745 TNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRN----KIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQST-----DADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRR 1800
++ KK VL N GYDDD + YI + + RYE+ L+GKGSFGQVVKA DH+T E VAIK+++N+K F QA E+RLLEL+ + D + ++H+ F+FRNH+C+ FELLS NLY+L++ F+G SL L RK A LC LL+ IIHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG Y + IDMWS GCIL E++TG P+F G +E DQ++ I+E+LG PP + + + + +F + ++ T D G + + GP + D F D LR L + P R++P AL+H + RR
Sbjct: 139 SSTKKEKKVL----NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ--LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRR 493
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q92630|DYRK2_HUMAN (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3) HSP 1 Score: 606.675 bits (1563), Expect = 0.000e+0 Identity = 286/411 (69.59%), Postives = 337/411 (82.00%), Query Frame = 1
Query: 583 DPLKRETDSSSKMKTSVNM----STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
D + R SS+ +K+ M +T ++P+ AM+Q+M KLT +EHHEIFSYP I+F+G NAKKR G+ GG NN GYDDDQ SY+ V HDH+AYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGSV+L GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 128 DSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5ZIU3|DYRK2_CHICK (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Gallus gallus OX=9031 GN=DYRK2 PE=2 SV=1) HSP 1 Score: 604.749 bits (1558), Expect = 0.000e+0 Identity = 287/403 (71.22%), Postives = 336/403 (83.37%), Query Frame = 1
Query: 595 RETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
+ TD + K+K SV ++P+ AM+Q+M KLTT+EH+EIF Y I+F+G NAKKR GV+GG NNCGYDDDQ SYI V HDHIAYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+N NVIH+++ F FR+H+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGS+IL GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 66 KSTDGTGKVKASV-----MTPEQAMKQYMQKLTTFEHNEIFGYTEIYFLGPNAKKRQGVIGGPNNCGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKMHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNNMNVIHMLENFTFRSHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSPKLLDSSKRAKNFVSSKGYPRYCTITTLSDGSIILNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAIRMTPSQALRHPWLRRR 463
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5U4C9|DYRK2_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Mus musculus OX=10090 GN=Dyrk2 PE=2 SV=1) HSP 1 Score: 601.282 bits (1549), Expect = 0.000e+0 Identity = 283/409 (69.19%), Postives = 335/409 (81.91%), Query Frame = 1
Query: 589 LKRETDSSSKMKTSVNM----STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
+ R SS+ +K+ M ++ ++P+ AM+Q+M KLT +EHHEIFSYP I+F+G NAKKR G+ GG NN GYDDDQ SY+ V HDH+AYRYEVLK++GKGSFGQVVKA DHK + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRS IKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGSV+L GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 128 IHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 536
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q9XTF3|MBK2_CAEEL (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 OS=Caenorhabditis elegans OX=6239 GN=mbk-2 PE=1 SV=1) HSP 1 Score: 567 bits (1460), Expect = 0.000e+0 Identity = 266/383 (69.45%), Postives = 318/383 (83.03%), Query Frame = 1
Query: 655 PDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
P+ A++ F +KL +E +EI++Y +FFVG++AKK+AGV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPPAS++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 395 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 777
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|A8WJR8|MBK2_CAEBR (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 OS=Caenorhabditis briggsae OX=6238 GN=mbk-2 PE=3 SV=2) HSP 1 Score: 565.074 bits (1455), Expect = 0.000e+0 Identity = 265/383 (69.19%), Postives = 316/383 (82.51%), Query Frame = 1
Query: 655 PDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
P+ A++ F +KL YE +EI++Y +FFVG++AKK+ GV+GG NN GYDD+ SY V HDHIAYRYEVLK++GKGSFGQV+KA DHK + VA+K+VRNEKRF RQA EEIR+L+ L++QD D N+IH++D F FRNH C+TFELLSINLYELIK+NKFQGFSL LVRKFAYS+LLCL+LL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC + QRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+ PGEDE DQLA I+E+LG PP K + KR + F TS+ YPRYC ++ DGSV+L G RSKRG+ RGPP S++ STALKN D+LF+DF RCL W PETRMTP +ALKH WLRR+
Sbjct: 394 PEDAVQTFGAKLVPYEKNEIYNYTRVFFVGSHAKKQPGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPESRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 776
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A1I8JL07 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0 Identity = 287/385 (74.55%), Postives = 337/385 (87.53%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
++P++AM+ +M KL+T+EHHEIFS+P ++FVG NA KR GV+GG NN GYDD+Q SY H AHDHI+YRYEVLK++GKGSFGQV+K DHKT VA+KMVRNEKRFTRQA+EEIR+LE L +QD D++ NV+HI++ F FRNHVC+TFELLS+NLYELIKKNKFQGFSLQLVRKFA+SIL CL++L+RNKIIHCDLKPENILLK QGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWS GCILAELYTG PIFPGEDEGDQLAC ME+LG PPT+L + KRT++FF+S+ +PRYC TDADG+ LKGGRS+RG+FRGPP SKTLSTAL+ C+D+ FLDF RCL W P+ RMTP EAL+H WL+R+
Sbjct: 1237 MTPETAMKLYMQKLSTFEHHEIFSFPQVYFVGQNANKRQGVVGGPNNSGYDDEQGSYQHTAHDHISYRYEVLKIIGKGSFGQVLKCHDHKTNSQVALKMVRNEKRFTRQASEEIRILEQLLRQDRDNSHNVVHILEHFTFRNHVCITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDMLHRNKIIHCDLKPENILLKCQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELYTGVPIFPGEDEGDQLACAMEVLGAPPTRLLEASKRTRVFFSSRGHPRYCSVETDADGATQLKGGRSRRGKFRGPPGSKTLSTALRGCEDRHFLDFLTRCLHWAPDERMTPHEALRHDWLKRR 1621
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A076G429 (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Cerebratulus lacteus OX=6221 PE=2 SV=1) HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0 Identity = 296/465 (63.66%), Postives = 360/465 (77.42%), Query Frame = 1
Query: 412 QKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKM-KTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
Q + N + V Q++E+++ + ++H N ++ Q++ P R + S+ + K S S+ +SP++AM+Q+M KL+++EHHEIF+YP I+FVG NAKKR GV+GG NN GYDDDQ SY+H+ HDHI+YRYEVLK++GKGSFGQVVKA DHK+ VA+KMVRNEKRF RQA EEIR+LE LKKQD D+ N+IHI + F+FRNH+C+TFELLS+NLYELIKKNKFQGFSLQLVRKFA+SIL CL+ L +N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILG KYGMPIDMWS GCILAEL TGYP+FPGEDEGDQLAC++E+LG PP KL D KR + F +S+ YPRYC +T DGS +L GRS+RG+ RGPP SK + T LK CDD LFLDF RCL W P TRM+P +AL+H WLRR+
Sbjct: 49 QHGPHLSNHGTVKVQQLYEDSKHRDSSHHHRENQDGAHQQQQSTENTKQVL-------PAVRPSSSAGSLYKNSGKRSSAVSPETAMKQYMHKLSSFEHHEIFNYPQIYFVGHNAKKRQGVIGGPNNNGYDDDQGSYVHIPHDHISYRYEVLKVIGKGSFGQVVKAYDHKSNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHITEHFVFRNHICITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDALNKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGAKYGMPIDMWSLGCILAELLTGYPLFPGEDEGDQLACVIELLGMPPQKLLDQSKRARNFISSKGYPRYCTVTTLPDGSTVLGPGRSRRGKTRGPPGSKEMVTGLKGCDDPLFLDFMRRCLDWDPATRMSPGQALRHAWLRRR 506
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A3Q3N826 (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 OS=Mastacembelus armatus OX=205130 PE=4 SV=1) HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0 Identity = 305/477 (63.94%), Postives = 361/477 (75.68%), Query Frame = 1
Query: 451 VTQMFEENRQQ------TNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK--QIPGNSITKTKYSNNIDG 1857
VTQ++EEN + N PL+++ L +T+ H + + TDS K+ LSP+ M+QFMSK++++EHHE+FSY +FF G NAKKR+GV+GG NN GYDDDQ SYIHV HDHIAYRYEVLK++GKGSFGQVVKA DHK VA+KMVRNEKRF RQAAEEIR+LE L+KQD DS+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+LLY+N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDE DQLACI+E+LG P KL D KR K F +S+ YPRYC +T DG+ +L GGRS+RG+ RGPP SK S ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+ + P + K S++ G
Sbjct: 69 VTQLYEENTNKRPVLTSQPNGLAPLSSTRPGLPLPDRHTSEPAQHCRQGSATSNKSTDSKPKVNP-------LSPEQVMKQFMSKMSSFEHHEVFSYTEVFFAGPNAKKRSGVMGGANNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKLQSHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDLLYKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLPDGTTVLNGGRSRRGKVRGPPGSKDWSAALKGCDDPLFLDFLKQCLEWDPSIRMTPSQALRHPWLRRRLPKPPAGTSVGEKVSSSKRG 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: K7GF33 (Dual specificity tyrosine phosphorylation regulated kinase 2 OS=Pelodiscus sinensis OX=13735 GN=DYRK2 PE=4 SV=1) HSP 1 Score: 615.535 bits (1586), Expect = 0.000e+0 Identity = 304/464 (65.52%), Postives = 362/464 (78.02%), Query Frame = 1
Query: 427 VENFNSFTVTQMFEEN-RQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMK----TSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
V + V Q+FE+N ++T +P ++ +K + + QI D R+ SSS +K T ++ ++P+ AM+Q+M KL+ +EHHEIFSYP IFF+G NAKKR GVLGG NNCGYDDDQ SY+ V HDHIAYRYEVLK++GKGSFGQVVKA DHKT + VA+KMVRNEKRF RQAAEEIR+LE L+KQD D+N NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC +T +DGSVIL GGRS+RG+ RGPP S+ ALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 79 VGSHGQIQVQQLFEDNSNKRTVLTTQPNGLAAVSKSGLSVVQDRQI-------DSAHRQQGSSSSLKLTDGTGKLKASFMTPEQAMKQYMQKLSAFEHHEIFSYPEIFFLGPNAKKRQGVLGGPNNCGYDDDQGSYVQVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKTHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPAQKLLDSSKRAKNFVSSKGYPRYCTITTLSDGSVILNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAIRMTPSQALRHPWLRRR 535
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A4W6CXM1 (Protein kinase domain-containing protein OS=Lates calcarifer OX=8187 GN=dyrk2 PE=4 SV=1) HSP 1 Score: 615.535 bits (1586), Expect = 0.000e+0 Identity = 307/485 (63.30%), Postives = 366/485 (75.46%), Query Frame = 1
Query: 451 VTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMST-------CLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRR---KQIPGNSITKTKYSNNIDGKDDPNG 1875
VTQ++EEN + +P+ S N L +++ + LP + T + + N ST LSP+ AM+QFMSK++++EHHE+FSYP ++FVG NAKKR+GV+GG NN GYDDDQ SYIHV HDHIAYRYEVLK++GKGSFGQVVKA DHK+ VA+KMVRNEKRF RQAAEEIR+LE L+KQD DS+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDE DQLACI+E+LG P KL D KR K F +S+ YPRYC +T DG+ +L GGRS+RG+ RGPP SK S ALK CDD LFLDF + L W P RMTP +AL+HPWLRR K G + T K S++ G +G
Sbjct: 69 VTQLYEENTNK-----RPVLTSQPNG-LAPLSSTRPGLPLPDRQTSASEPTHHCRQGSATSNKSTDSKPKPNPLSPEQAMKQFMSKMSSFEHHEVFSYPEVYFVGPNAKKRSGVMGGANNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKSQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLPDGTTVLNGGRSRRGKVRGPPGSKDWSAALKGCDDPLFLDFLKQSLEWDPALRMTPSQALRHPWLRRRLPKPPAGTATTGEKTSSSKRGTTTSDG 547
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:103042530]) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 301/465 (64.73%), Postives = 352/465 (75.70%), Query Frame = 1
Query: 427 VENFNSFTVTQMFEENRQQTN------NHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
V N V Q+FEEN + N P+ + Q T ++ + +S K S L+P+ AM+Q++SKL+T+EH EIF+YP IFFVG NAKKR GV+GG+NN GYDDDQ SYIHV HDHIAYRYEVLK++GKGSFGQVVKA DHKT + VA+KMVRNEKRF RQAAEEIR+LE L+KQD DS NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDEGDQLAC++E+LG P KL D KR K F +S+ YPRYC ++ DG+V L GGRS+RG+ RGPP SK TALK CDD LFLDF +CL W P RMTP +AL+HPWLRR+
Sbjct: 70 VGNHQQIHVQQLFEENSNKRTVLTTQPNGLTPVTRAGLALPERQQETTQ-----------CRQGSSTSIKSTDSKPKPAPLTPEQAMKQYLSKLSTFEHQEIFNYPEIFFVGPNAKKRPGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKTHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIELLGMPSQKLLDSSKRAKNFISSKGYPRYCTVTSLPDGTVALNGGRSRRGKLRGPPGSKDWVTALKGCDDPLFLDFLKQCLEWDPTLRMTPSQALRHPWLRRR 523
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0 Identity = 267/385 (69.35%), Postives = 313/385 (81.30%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
L + A++Q+ +LT E E+ +Y IFFVG NAKKR V GG+NNCGYDDDQ YIHV HDHIAYRYE LK++GKGSFGQV K DHK + +A+KMVRNEKRF RQAAEEIR+LE LKKQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L R+KIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCILAEL TGYP+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ +PRYC +T ++G+++L G RS+RG+ RGPP SK TALK CDD F+DF +CL W P TRMTP AL+HPWL ++
Sbjct: 136 LGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTTLSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKR 520
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 567 bits (1460), Expect = 0.000e+0 Identity = 267/385 (69.35%), Postives = 313/385 (81.30%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
L + A++Q+ +LT E E+ +Y IFFVG NAKKR V GG+NNCGYDDDQ YIHV HDHIAYRYE LK++GKGSFGQV K DHK + +A+KMVRNEKRF RQAAEEIR+LE LKKQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L R+KIIHCDLKPENILLKQQGRSGIKVIDFGSSC +HQR+YTYIQSRFYRAPEVILG +YGMPIDMWSFGCILAEL TGYP+FPGEDEGDQLAC+ME+LG PP KL + KR K F S+ +PRYC +T ++G+++L G RS+RG+ RGPP SK TALK CDD F+DF +CL W P TRMTP AL+HPWL ++
Sbjct: 128 LGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTTLSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKR 512
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 464.922 bits (1195), Expect = 2.526e-153 Identity = 218/393 (55.47%), Postives = 281/393 (71.50%), Query Frame = 1
Query: 616 KMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
K++T +SP +A++ F S+LT YE EI Y I+++G + KK G G N GYDD+ SY+ V HDHIAYRYEVL+++GKGSFGQV+K LDHKT E VAIK++RN+KRF +QA E+++L+ ++++D DS NVIH+ + F FRNH+C++FELL NLYELIKKN FQGFSL L+R+FA+S+L CL++L+R KIIHCDLKPENILL Q+G+ IKV+DFGSSC E QR+YTYIQSRFYR+PEVILG Y M IDMWS GCILAELYTGYP+FPGE E +Q+ACIME++G PP R ++FF S+ PR T++ G + P SK L++ LK +D LFLDF RCL W P RMTP E ++H W+
Sbjct: 120 KIRTYEGQRLPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNV---TNSKGK-------------KRRPNSKELASVLKT-NDPLFLDFIRRCLVWDPTKRMTPDEGMQHEWI 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 464.537 bits (1194), Expect = 4.194e-153 Identity = 218/393 (55.47%), Postives = 281/393 (71.50%), Query Frame = 1
Query: 616 KMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
K++T +SP +A++ F S+LT YE EI Y I+++G + KK G G N GYDD+ SY+ V HDHIAYRYEVL+++GKGSFGQV+K LDHKT E VAIK++RN+KRF +QA E+++L+ ++++D DS NVIH+ + F FRNH+C++FELL NLYELIKKN FQGFSL L+R+FA+S+L CL++L+R KIIHCDLKPENILL Q+G+ IKV+DFGSSC E QR+YTYIQSRFYR+PEVILG Y M IDMWS GCILAELYTGYP+FPGE E +Q+ACIME++G PP R ++FF S+ PR T++ G + P SK L++ LK +D LFLDF RCL W P RMTP E ++H W+
Sbjct: 128 KIRTYEGQRLPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNV---TNSKGK-------------KRRPNSKELASVLKT-NDPLFLDFIRRCLVWDPTKRMTPDEGMQHEWI 503
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 571.237 bits (1471), Expect = 0.000e+0 Identity = 266/384 (69.27%), Postives = 314/384 (81.77%), Query Frame = 1
Query: 640 STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPW 1791
S SPD A+R + KLT YEH EI++Y I+FVG NAKKR GV+GG +NCGYDD+Q SY+HVAHDH+AYRYEVLK++GKGSFGQVVKA DHKT VA+KMVRNEKRF RQAAEEIR+LE L+KQD +++ N+IH+++ F FR HVCMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L+RN+IIHCDLKPENILLKQ GRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEV+LG +YG PIDMWS GCILAEL TG P+ PGEDEGDQLAC ME+LG PP +L KR++ F +S+ +PRYC + DG+V+L GRS+RG+ RGPP S+ L AL+ CDD L LDF CL W P R+TP +AL+HPW
Sbjct: 91 SQLASPDQAVRLYGQKLTAYEHQEIYNYAEIYFVGHNAKKRPGVVGGASNCGYDDEQGSYVHVAHDHVAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRENSMNIIHLLESFTFRGHVCMTFELLSMNLYELIKKNKFQGFSLALVRKFAHSILQCLDTLHRNRIIHCDLKPENILLKQPGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVVLGARYGPPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELLGMPPQRLLAQGKRSRNFVSSRGHPRYCGVTEAPDGAVVLNAGRSRRGKPRGPPGSRELPAALRGCDDPLLLDFLRGCLEWEPSERLTPAQALRHPW 474
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 564.303 bits (1453), Expect = 0.000e+0 Identity = 265/391 (67.77%), Postives = 324/391 (82.86%), Query Frame = 1
Query: 640 STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIK-VIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQI 1809
ST +SP+ AMR++M +L+ +EHHEIF+Y ++FVG +AKKR L G NN G+DD+Q SYIHV HDH+AYRYEVL+++GKGSFGQVVKA DH+T + VA+KMVRNEKRF RQAAEEIR+LE LKKQD ++ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSLQ+VRKFA+SILLCL L++N+IIHCDLKPENILL+QQGRSGIK +IDFGSSC EHQR+YTYIQSRFYRAP GG+YG+PIDMWS GCILAEL TG P+ PGEDEGDQLAC ME+ G PP +L + KR + FF+S +PRYC +T G V+L GGR++RG+ RGPP+S+ +TALK CDD LF+DF +CL W P TR+TP +ALKHPWLRR+ +
Sbjct: 101 STAMSPEQAMRKYMHRLSMFEHHEIFNYHEVYFVGPSAKKRQATLSGVNNNGFDDEQGSYIHVPHDHVAYRYEVLRVIGKGSFGQVVKAYDHRTHQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKENTMNVIHMLESFNFRNHICMTFELLSMNLYELIKKNKFQGFSLQVVRKFAHSILLCLNALHKNRIIHCDLKPENILLRQQGRSGIKIIIDFGSSCYEHQRVYTYIQSRFYRAP----GGRYGLPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELTGSPPARLLEQSKRARQFFSSLGHPRYCTVTTLPGGPVVLNGGRTRRGKLRGPPSSRDWTTALKGCDDHLFIDFLKKCLDWDPATRLTPSQALKHPWLRRRPL 487
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk1aa (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Source:ZFIN;Acc:ZDB-GENE-050302-29]) HSP 1 Score: 289.271 bits (739), Expect = 1.121e-85 Identity = 158/348 (45.40%), Postives = 208/348 (59.77%), Query Frame = 1
Query: 850 RYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRN----KIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQST-------DADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQL-FLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPG-NSITKTKYSNNID 1854
RYE+ L+GKGSFGQVVKA DH+ E VAIK+++N+K F QA E+RLLEL+ K D D ++H+ F+FRNH+C+ FELLS NLY+L++ F+G SL L RKFA +C LL+ IIHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG Y + IDMWS GCIL E++TG P+F G +E DQ+ I+E+LG PPT + + + + +F + V+ T GS L P + + A D L F D LR L + P+TR+TP AL+H + ++ G N+ S ID
Sbjct: 161 RYEIDSLIGKGSFGQVVKAYDHQEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTDMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQ--MCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGLPPTHMLEQAPKARKYFERLSDGSWTVKKTKDSKREYKTAGSRKLHDIIGVESGG---PGGRRMGEAGHTVADYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTSNSVSTSPAID 503
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007952.1 (pep scaffold:Pmarinus_7.0:GL476685:157428:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007952.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 245.743 bits (626), Expect = 9.083e-75 Identity = 139/330 (42.12%), Postives = 189/330 (57.27%), Query Frame = 1
Query: 826 VAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKK-QDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIP 1812
V H+H+ YRYEVL++LG+GSFG+V+K LDHK+ E VAIK++ N RF R +E+LK+ Q + +I +++ F FR C+ FELL+ NL +K QGF L++VR FA S+L LE L +IH DLKP NI + +K+ DFG SC +H+ +T IQ+R YRAPEVIL Y P DMWS GC LAEL++G +FPG DQL IME+ G PP + + + FF + D +V L G + P S+ L AL+ D+ F DF CL W PE R+TP A+ H W+R ++P
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHR--REIEILKRLQTARESSKIIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFACK----------DFSSNVRLNRGLVRV------PGSRALPLALRTTDEH-FTDFIRSCLQWDPEWRLTPHGAMDHEWVRAPRMP 311
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007958.1 (pep scaffold:Pmarinus_7.0:GL476685:157443:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007958.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 244.202 bits (622), Expect = 3.679e-74 Identity = 135/325 (41.54%), Postives = 184/325 (56.62%), Query Frame = 1
Query: 826 VAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKK-QDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLR 1797
V H+H+ YRYEVL++LG+GSFG+V+K LDHK+ E VAIK++ N RF R +E+LK+ Q + +I +++ F FR C+ FELL+ NL +K QGF L++VR FA S+L LE L +IH DLKP NI + +K+ DFG SC +H+ +T IQ+R YRAPEVIL Y P DMWS GC LAEL++G +FPG DQL IME+ G PP + + + FF + + + + V P S+ L AL+ D+ F DF CL W PE R+TP A+ H W+R
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHR--REIEILKRLQTARESSKIIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFAITKPTHWDINNHRGLVRV---------------PGSRALPLALRTTDEH-FTDFIRSCLQWDPEWRLTPHGAMDHEWVR 307
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: YAK1 (Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]) HSP 1 Score: 261.536 bits (667), Expect = 1.468e-75 Identity = 144/372 (38.71%), Postives = 221/372 (59.41%), Query Frame = 1
Query: 778 GTNNCGYDDDQNSYIHVAHDHIAY----RYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELL-KKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFF----------TSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPA------SKTLSTALKNCDDQL-----FLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPG 1815
G N G+D+ + YI +D + +Y VL +LG+G+FGQVVK + T E +A+K+V++ + Q+ E ++LELL +K DP + + + + D F+ +NH+C+ FELLS NLYEL+K+NKF G S+QL+R F IL L +L +K+IHCDLKPENILL + +K+IDFGSSC E + +YTYIQSRFYRAPE+ILG Y IDMWS GCI+AEL+ G PIFPG E +QL I++ LG PP+ + D+ K + F ++Q++ ++ + +++ K + + P K++ + + D ++ + F L P R TP++A+ HP++ +++ G
Sbjct: 340 GKCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFITKQEFTG 711
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 142.124 bits (357), Expect = 6.878e-38 Identity = 99/327 (30.28%), Postives = 162/327 (49.54%), Query Frame = 1
Query: 850 RYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVR--NEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKK----NKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTY---IQSRFYRAPEVILGGK-YGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTS--QRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
+++ L+ LG G++ V K L+ TG VA+K V+ +E+ A EI L++ LK + N++ + D N + + FE + +L + + N +G L LV+ F + +L L + NKI+H DLKP+N+L+ ++G+ +K+ DFG + + T+ + + +YRAP+V++G + Y ID+WS GCILAE+ TG P+FPG ++ +QL I +I+G P L + + + QR PR Q L K D +DF L P+ R++ K+AL HPW
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE------NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQ---------------------------VLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: KNS1 (Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation [Source:SGD;Acc:S000003942]) HSP 1 Score: 139.813 bits (351), Expect = 1.196e-34 Identity = 84/289 (29.07%), Postives = 144/289 (49.83%), Query Frame = 1
Query: 802 DDQNSYIHVAHDHIAY--RYEVLKLLGKGSFGQVVKALDHK-TGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILL---------------------KQQGRSG---------IKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQP-PTKLTDICKRTKIFFTSQ 1566
D Y++ +D R+ V LLG+G+FG+V+K +D+K VA+K++R R+ A E+R+L+ + DP + + + F ++NH+C+ +L ++Y+ + N F ++ A ++ + L+ IIH DLKPENIL+ +++ G IK+IDFGS+ ++ I +R YRAPE++LG + P D+WS C+L EL G ++P + + +A + I G P PT + D K+F+ S+
Sbjct: 294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIID-----KMFYKSK 577
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 135.961 bits (341), Expect = 1.378e-34 Identity = 98/350 (28.00%), Postives = 165/350 (47.14%), Query Frame = 1
Query: 841 IAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVR---NEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFR-NHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGG-KYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTD-ICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNS-ITKTKYSNNIDGKDDP 1869
I RY L +G G+FG V A D T + VAIK + + ++ E++LL+ L+ + N+I + D F+ + EL +L+ L++ + Q V+ F Y IL L+ ++ +IH DLKP NIL+ + +K+ DFG + + ++ Y+ +R+YRAPE++L KY + +D+WS GCI AE+ G P+FPG+D Q + I ++LG PP + + IC + F + R + P S+ T + +D + L + P+ R+T +AL HP+ P + + K+ + + D P
Sbjct: 19 ITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHE------NLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEK---QFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINEN--CDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPI------------------------PFSERFKTVEPDA-----VDLLEKMLVFDPKKRITAADALAHPYSAPYHDPTDEPVADAKFDWHFNDADLP 328
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 129.798 bits (325), Expect = 4.395e-33 Identity = 100/346 (28.90%), Postives = 169/346 (48.84%), Query Frame = 1
Query: 841 IAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVR--NEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQF----IFR-NHVCMTFELLSINLYELI--KKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQR----------IYTYIQSRFYRAPEVILG-GKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGN 1818
I +Y+++ L+G+G++G V A+ +G VAIK ++ ++K F + EI+LL + + N+I I+D+ I + N V + EL+ +L ++I + + F S V+ F Y IL L+ ++ ++IH D+KP N+LL +KV DFG + C + Y+ +R+YRAPE++L +Y +D+WS GCILAE+ +G P+FPG D QL I+E+LG P + + K S+R Y PP + + + + +D + L + P+ R++ EAL+HP+L P +
Sbjct: 9 IPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLL--NSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIK-------SKRAKEYIAN------------------LPMRPPLPWETVWSKTDLNPDM-IDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPSD 321
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO46144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQP1]) HSP 1 Score: 601.282 bits (1549), Expect = 0.000e+0 Identity = 306/493 (62.07%), Postives = 362/493 (73.43%), Query Frame = 1
Query: 433 NFNSFTVTQMFEENRQQTNNHFK----PLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPG--------NSITKTKYSNNIDGKDDPNG 1875
+ S V Q+FEE +TNN + P+ + G +++ + +I +R++ +S T S + + AM+Q+M KL+ YE HEIF+Y I+FVG AKKR GV+GG NNCGYDD+Q SYIHV DHIAYRYEVLK++GKGSFGQVVKALDHKT VA+KMVRNEKRF RQA EEIR+LE LKKQD D+ N+IH+++ F FRNHVCMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILG +YGMPIDMWSFGCILAEL TGYP+FPGEDEGDQLAC ME+LG P KL + KR K F S+ YPRYC +T DGSV + GGRS+RG+ RG P SKT ALK CDD +F+DF RCL W P RMTP +AL+HPWLRR+ +P S T T+ + GK P G
Sbjct: 38 HLGSIQVQQLFEE---ETNNKLQGKSMPVVHDHGLPSVSRTGRSPSVIE--------RRQSSNS----TGSQKSRSFTAEVAMKQYMHKLSGYETHEIFNYSQIYFVGEAAKKRQGVVGGANNCGYDDEQGSYIHVPKDHIAYRYEVLKIIGKGSFGQVVKALDHKTNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHMLEHFTFRNHVCMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACNMELLGYIPEKLRETSKRAKNFINSKGYPRYCTITTLPDGSVAVSGGRSRRGKTRGAPNSKTFVQALKGCDDAMFIDFLKRCLEWDPSARMTPSQALRHPWLRRRALPRAPESNNNLASATSTEKRRSAVGKFPPTG 515
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO36294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ45]) HSP 1 Score: 436.802 bits (1122), Expect = 4.152e-147 Identity = 208/351 (59.26%), Postives = 272/351 (77.49%), Query Frame = 1
Query: 685 KLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCL 1737
++TT+E EI YP ++F+G +AKK GV G N YDDD SY+ HDH+AYRYEVL++LGKGSFGQVVKALDHKTG+ VA+K++RN+KRF +QA E+++L+ L+K+D D+ N+IH+I+ F FRNH+C+TFEL+ +NLYELIKKN FQGFSL L+R+FA+++L CL+++++ KIIHCDLKPENILL+Q+G++ IKVIDFGSSC EHQR+YTYIQSRFYR+PEVILG Y M IDMWSFGCILAELYTGYP+FPGE+E +QLACIME+LG P KL + R ++FF S+ PR C+ T++ G + P+S+ +S ALK +D LFLDF +CL
Sbjct: 4 RITTFEQSEILDYPEVWFLGLDAKKIDGVPGAPQNNNYDDDNGSYLKALHDHLAYRYEVLEVLGKGSFGQVVKALDHKTGQHVAVKIIRNKKRFHQQALVEVKILDNLRKKDKDNTHNLIHMIEHFYFRNHLCITFELMGMNLYELIKKNNFQGFSLALIRRFAFALLHCLKVIHKEKIIHCDLKPENILLRQRGQTSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPSPKLIESASRRRLFFDSKGIPR-CI--TNSKGK-------------KRRPSSRDISAALKT-NDALFLDFLKQCL 337
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO45187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTC8]) HSP 1 Score: 284.648 bits (727), Expect = 3.108e-87 Identity = 159/361 (44.04%), Postives = 213/361 (59.00%), Query Frame = 1
Query: 787 NCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLY----RNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRY-CVQSTD------ADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQL-FLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKT 1833
N GYDD+ YI A + RYE+ L+GKGSFGQV KA DH+ E +A+K+++N+K F QA E++LLEL+ K DPD ++ + F++RNH+C+ FELLS NLY+L++ F+G SL L RKFA +C LL+ IIHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG Y + IDMWS GCIL E++TG P+F G +E DQ+ I+E+LG PP + D + + FF Y C++ D + GS L P + L A D L F D LR L + +TR+ P AL H + ++ G + T +
Sbjct: 57 NDGYDDENYDYIVKAGEKWFDRYEIESLIGKGSFGQVCKAYDHQEKEHIAVKIIKNKKPFLNQAQIEVKLLELMNKNDPDGKYYIVRLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQ--MCTALLFLCSPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQIGQRIYQYIQSRFYRSPEVLLGIPYNLAIDMWSLGCILVEMHTGEPLFSGANEFDQMMKIVEVLGMPPKDILDNAPKARKFFDRLPDGSYQCLKVKDGVKEYLSPGSRKLHDILGCETGG---PGGRRLGEAGHTLQDYLKFKDLILRMLDYDRKTRIVPYAALHHCFFKKTAEEGTNTTHS 412
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO33758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR83]) HSP 1 Score: 196.823 bits (499), Expect = 5.165e-55 Identity = 110/349 (31.52%), Postives = 186/349 (53.30%), Query Frame = 1
Query: 799 DDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILL-------------KQQGR----SGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
DD+ I+ D + RYEV LLG+G+FG+V++ D KTG+ VA+K+++N +++ A EI++LE + +++ I ++D F H+C+ FE + +++++ +K N ++ + L VR +Y +++ ++ L+ K+ H DLKPEN+L KQ R S +++IDFGS+ EH+ T + +R YRAPEVIL + P D+WS GCI+ ELYTG+ +F + + LA + I+G P+ ++TK F+ + + G + P LS + + QLF + L + PE R+T KEA++HP+
Sbjct: 107 DDEDGHLIYHKGDQLHSRYEVHCLLGEGTFGKVLECYDKKTGDVVAVKVIKNIEKYREAAKLEIKVLEKINQKNRYGKSLCIKMLDWFNHHGHMCLVFEKMGLSVFDFMKDNNYEPYPLDQVRHISYQLIVAVKFLHEMKLTHTDLKPENMLFVNSDCDVFYNKDTKQDQRYVKSSHMRLIDFGSATFEHEHHSTTVSTRHYRAPEVILELGWSYPCDIWSIGCIMFELYTGFTLFQTHENREHLAMMERIIGPIPSDFAKKSRKTKYFYKG----KLEWDEKSSSGKYV--------RENCKPLKKYMLSDSEGH---QLFFNLLDYLLEYDPEKRITAKEAMQHPFF 440
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO49238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGV4]) HSP 1 Score: 189.504 bits (480), Expect = 1.744e-53 Identity = 120/332 (36.14%), Postives = 178/332 (53.61%), Query Frame = 1
Query: 859 VLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILL----KQQGRSGIKVIDFGSSCCEHQRI-YTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQ--------RYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTAL-------KNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
VL+ LG+G+FGQVVK T E VAIK++++ + RQ EI +L L ++ ++ N + I+ F +NH C+ FE+L NLY+ +K++KF L+ +R +L+ L L +IH DLKPENI+L KQ R +KVIDFGS+ + + TY+QSR+YRAPEVILG + IDMWS GC++AEL+ G+P++PG E DQ+ I++ G P L + +T FF + + + + K R A LS++L + D F+ R LT E R+TP+EAL H ++
Sbjct: 1 VLEFLGRGTFGQVVKCWKKGTNELVAIKILKDHPSYARQGQIEISILAKLSAENSEAY-NFVRAIECFQHKNHTCLVFEMLQQNLYDYLKQSKFNPLPLKHIRPIVQQVLVALSKLRTLGLIHADLKPENIMLVDPDKQPFR--VKVIDFGSATHVSKVVCSTYLQSRYYRAPEVILGLPFCESIDMWSLGCVIAELFLGWPLYPGSSEFDQIRYIIQTQGLPYDHLLNNATKTSRFFKKAINTHTGVLEWKLKNANEHERETKIPSKEARKYIFNSLDDIAQVNLSSSLTGNERIAEKIDRYEFVSLLKRMLTIDQEKRITPEEALSHQFV 329
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:101170635]) HSP 1 Score: 601.282 bits (1549), Expect = 0.000e+0 Identity = 298/482 (61.83%), Postives = 364/482 (75.52%), Query Frame = 1
Query: 451 VTQMFEENRQQ------TNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK-------QIPGNSITKTKYSNNIDG 1857
VT ++EEN + N PL+++ L + ++ H ++ + +S+K S + L+ + AM+QFMSK++++EHHE+FS+ ++F+G +AKKR+GVLGG NN GYDDDQ SYI V HDHIAYRYEVLK++GKGSFGQVVKA DHKT VA+KMVRNEKRF RQAAEEIR+LE LKKQD DS+ NVIH+++ F FRNH+CMTFELLS+NLYELIKKNKFQGFSL LVRKFA+SIL CL+ L++N+IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YGMPIDMWS GCILAEL TGYP+ PGEDE DQLACI+E+LG P K+ D KR K F +S+ YPRYC +T +DG+ +L GGRS+RG+ RGPP SK STALK CDD LFLDF +CL W P RMTP +AL+H WLRR+ PG+ + +K + DG
Sbjct: 60 VTPLYEENMNKRPVLTSQPNGLAPLSSTRPGLPLPERQSSEAAQHG-------RQSSATSNKPADSKPKTNPLTAEQAMKQFMSKMSSFEHHEVFSFSEVYFIGPSAKKRSGVLGGPNNGGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKILDASKRAKNFVSSKGYPRYCTVTTLSDGTTVLNGGRSRRGKVRGPPGSKVWSTALKGCDDPLFLDFLKQCLEWDPAHRMTPSQALRHSWLRRRLPKPPTGTTPGDKTSSSKRATT-DG 533
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 558.525 bits (1438), Expect = 0.000e+0 Identity = 262/389 (67.35%), Postives = 312/389 (80.21%), Query Frame = 1
Query: 637 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
M L+PD A+R + S+L+ E EI SYP ++FVG NAKKR V GG+NNCGYDD+Q YIHV HDH+AYRYE LK++GKGSFGQV K DHK + +A+KMVRNEKRF RQA EEIR+LE L KQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L R++IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL TGYP+FPGEDE DQLAC ME+LG PP K+ + KR K F S+ +PRYC +T G+ +L G RS+RG+ RGPPASK + ALK C+D F+DF +CL W P +R+TP +AL+HPWL R+
Sbjct: 146 MCGPLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRR 534
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 558.525 bits (1438), Expect = 0.000e+0 Identity = 262/389 (67.35%), Postives = 312/389 (80.21%), Query Frame = 1
Query: 637 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
M L+PD A+R + S+L+ E EI SYP ++FVG NAKKR V GG+NNCGYDD+Q YIHV HDH+AYRYE LK++GKGSFGQV K DHK + +A+KMVRNEKRF RQA EEIR+LE L KQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L R++IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL TGYP+FPGEDE DQLAC ME+LG PP K+ + KR K F S+ +PRYC +T G+ +L G RS+RG+ RGPPASK + ALK C+D F+DF +CL W P +R+TP +AL+HPWL R+
Sbjct: 146 MCGPLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRR 534
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 557.37 bits (1435), Expect = 0.000e+0 Identity = 262/389 (67.35%), Postives = 312/389 (80.21%), Query Frame = 1
Query: 637 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
M L+PD A+R + S+L+ E EI SYP ++FVG NAKKR V GG+NNCGYDD+Q YIHV HDH+AYRYE LK++GKGSFGQV K DHK + +A+KMVRNEKRF RQA EEIR+LE L KQD + NV+H+++ F FRNH+CMTFELLS+NLYELIK+NKFQGFSL LVRKFA+SIL CLE L R++IIHCDLKPENILLKQQGRSGIKVIDFGSSC EHQR+YTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL TGYP+FPGEDE DQLAC ME+LG PP K+ + KR K F S+ +PRYC +T G+ +L G RS+RG+ RGPPASK + ALK C+D F+DF +CL W P +R+TP +AL+HPWL R+
Sbjct: 88 MCGPLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRR 476
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk4 (dual specificity tyrosine-phosphorylation-regulated kinase 4 [Source:NCBI gene;Acc:101159741]) HSP 1 Score: 460.685 bits (1184), Expect = 6.686e-152 Identity = 217/382 (56.81%), Postives = 275/382 (71.99%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWL 1794
+SP A+ F +LT +E EI +Y ++F+G ++K G G +N GYDD+ SYI V HDHIAYR+EVL+++GKGSFGQV+K LDHKT E VAIKM+RN+KRF QA E+++LE++KK+D D+ NVIH+ + F FRNH+C++FELL +NLYELIKKN FQGFSL L+R+FA+++L CL++L++ KIIHCDLKPENILL Q+G IKV+DFGSSC E QR+YTYIQSRFYR+PEVILG Y M IDMWS GCILAEL+TGYP+FPGE E +Q+ACIME+LG PP R K+FF S+ PR T++ G + P SK LS ALK D LFL+F CLTW P RMTP E L+H W+
Sbjct: 132 MSPSEALNNFQERLTEFEQEEINAYAEVWFLGLGSQKIEGSQGAPHNSGYDDEHGSYIRVLHDHIAYRFEVLEVIGKGSFGQVLKCLDHKTNELVAIKMIRNKKRFHHQALVELKILEVIKKKDKDNLHNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSLALIRRFAHALLRCLQMLHKEKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELHTGYPLFPGESEVEQIACIMEVLGMPPNDFVQSASRRKLFFDSKGNPRNI---TNSKGK-------------KRRPNSKELSAALKTTDP-LFLEFIKGCLTWDPTKRMTPDEGLQHQWI 496
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 1097.03 bits (2836), Expect = 0.000e+0 Identity = 561/561 (100.00%), Postives = 561/561 (100.00%), Query Frame = 1
Query: 202 MYTMDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGXXXXXXXXXXXXXXXXXXXXSLLNKQRPFQQQKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNGLNL 1884
MYTMDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGAANNIEKTNNNFTNNTISNASLLNKQRPFQQQKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNGLNL
Sbjct: 1 MYTMDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGAANNIEKTNNNFTNNTISNASLLNKQRPFQQQKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNGLNL 561
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 1090.87 bits (2820), Expect = 0.000e+0 Identity = 558/558 (100.00%), Postives = 558/558 (100.00%), Query Frame = 1
Query: 211 MDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGXXXXXXXXXXXXXXXXXXXXSLLNKQRPFQQQKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNGLNL 1884
MDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGAANNIEKTNNNFTNNTISNASLLNKQRPFQQQKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNGLNL
Sbjct: 1 MDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGAANNIEKTNNNFTNNTISNASLLNKQRPFQQQKQKDVENFNSFTVTQMFEENRQQTNNHFKPLNNSSGNKYLNQINTNSQIIHLPKIEDPLKRETDSSSKMKTSVNMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNGLNL 558
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000042409.1 (SMESG000042409.1) HSP 1 Score: 606.29 bits (1562), Expect = 0.000e+0 Identity = 289/403 (71.71%), Postives = 338/403 (83.87%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 1857
++ ++AM+ +M+KLT++EHHEIFSYP I+FVG NAKKR GV+GGT+NCGYDD+QNSY++V HDHIAYR+EV+K+LGKGSFGQVVKA DHK VA+KM+RNEKRFTRQAAEEIR+LE LKKQDP SN N++HI++ F FRNHVCMTFELL+INLYELIKKNKFQGFSLQLVRKFA+SILLCL+LL+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILG Y M IDMWSFGCILAEL+TG P+FPGEDE DQLACI+E+LG PP L + KR K+F S+ YPRYC D DG +ILKG RSKRG++RGPP +K++ + LKNC D F+ F RCL W+P+ RMTP+EALK WLRRK P N S +DG
Sbjct: 153 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRK--PPNHFQDNCPSTAVDG 553
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000042409.1 (SMESG000042409.1) HSP 1 Score: 605.905 bits (1561), Expect = 0.000e+0 Identity = 289/403 (71.71%), Postives = 338/403 (83.87%), Query Frame = 1
Query: 649 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILXXXXXXXXXXXXPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 1857
++ ++AM+ +M+KLT++EHHEIFSYP I+FVG NAKKR GV+GGT+NCGYDD+QNSY++V HDHIAYR+EV+K+LGKGSFGQVVKA DHK VA+KM+RNEKRFTRQAAEEIR+LE LKKQDP SN N++HI++ F FRNHVCMTFELL+INLYELIKKNKFQGFSLQLVRKFA+SILLCL+LL+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILG Y M IDMWSFGCILAEL+TG P+FPGEDE DQLACI+E+LG PP L + KR K+F S+ YPRYC D DG +ILKG RSKRG++RGPP +K++ + LKNC D F+ F RCL W+P+ RMTP+EALK WLRRK P N S +DG
Sbjct: 107 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRK--PPNHFQDNCPSTAVDG 507
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000064198.1 (SMESG000064198.1) HSP 1 Score: 552.362 bits (1422), Expect = 0.000e+0 Identity = 271/417 (64.99%), Postives = 329/417 (78.90%), Query Frame = 1
Query: 634 NMSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDAD---GSVI-------LXXXXXXXXXXXXPPASKTLSTALK----------NCDDQL-------FLDFTLRCLTWIPETRMTPKEALKHPWLRRK 1803
N+ + L+PD AM+ +M +L+T+EHHEIF+YP I+FVG NAKK+ G+ G NN GYDD+ SY HVAHDH++YRYE+LK+LGKGSFGQVVKA DHKTG VA+KMVRNEKRF +QA EEI++LE LK QD D+N N++HI++ F FRNHVCMTFELL+INLY LIKKNKFQGFSL LV+KFAYSIL+CL+LL++NK+IHCDLKPENILLKQQGRSGIKVIDFGSSC +HQRIYTYIQSRFYRAPEVILGGKY + IDMWSFGCIL E+ TGYP+FPGEDE DQLACI+E+LG PP D CKR+K FF S+ YPRYC T+ + G I LKG +SKRG++RG P SK+L++ + N D ++ F++F L+CL W+P+ R TPKEAL+H WLRRK
Sbjct: 73 NVPSPLTPDQAMKLYMHRLSTFEHHEIFNYPQIYFVGHNAKKKHGISVGANNNGYDDEHGSYQHVAHDHVSYRYEILKILGKGSFGQVVKAYDHKTGMFVALKMVRNEKRFAKQALEEIKILEQLKIQDKDNNKNIVHILEHFTFRNHVCMTFELLNINLYSLIKKNKFQGFSLLLVKKFAYSILVCLDLLHKNKVIHCDLKPENILLKQQGRSGIKVIDFGSSCYDHQRIYTYIQSRFYRAPEVILGGKYSVQIDMWSFGCILVEMLTGYPLFPGEDEMDQLACIIEVLGMPPQNFLDQCKRSKEFFCSKGYPRYCQLETETETQSGKTIINGVVFYLKGCKSKRGKYRGSPGSKSLASIVNAMNPDLNSDANIDSEIQLKDFTNFINFLLKCLEWVPDDRFTPKEALRHEWLRRK 489 The following BLAST results are available for this feature:
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30034243 ID=SMED30034243|Name=Dual specificity tyrosine-phosphorylation-regulated kinase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2614bpback to top protein sequence of SMED30034243-orf-1 >SMED30034243-orf-1 ID=SMED30034243-orf-1|Name=SMED30034243-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=562bp MYTMDKIPNNTHLPSLSTNRHHNLVSSTANSYNDDNKTGAANNIEKTNNNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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