corticotropin-releasing factor receptor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30034211 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of corticotropin-releasing factor receptor vs. Ensembl Human
Match: CRHR1 (corticotropin releasing hormone receptor 1 [Source:HGNC Symbol;Acc:HGNC:2357]) HSP 1 Score: 172.94 bits (437), Expect = 6.391e-48 Identity = 124/375 (33.07%), Postives = 186/375 (49.60%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRI--LQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE V V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Human
Match: CRHR1 (corticotropin releasing hormone receptor 1 [Source:HGNC Symbol;Acc:HGNC:2357]) HSP 1 Score: 172.94 bits (437), Expect = 6.391e-48 Identity = 124/375 (33.07%), Postives = 186/375 (49.60%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRI--LQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE V V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Human
Match: CRHR1 (corticotropin releasing hormone receptor 1 [Source:NCBI gene;Acc:1394]) HSP 1 Score: 172.94 bits (437), Expect = 6.391e-48 Identity = 124/375 (33.07%), Postives = 186/375 (49.60%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRI--LQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE V V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Human
Match: CRHR2 (corticotropin releasing hormone receptor 2 [Source:HGNC Symbol;Acc:HGNC:2358]) HSP 1 Score: 161.384 bits (407), Expect = 8.302e-44 Identity = 114/374 (30.48%), Postives = 184/374 (49.20%), Query Frame = 3
Query: 192 EYCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC---VNGRHEEINL---VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC D + CWP + AG PCP F+G +Y++ NA R+C +G+W A+K NY+ C ++ + + +L + + ++ G+ +S+ L +A LF ++++C RN IH +L + FILR+ + +L ++ H + + + + + F WM +EG YL I TY RLR F IGW P + A + ++ W + +DY PII +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR VR R W++
Sbjct: 24 SYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTW-ASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQD 365
BLAST of corticotropin-releasing factor receptor vs. Ensembl Human
Match: CRHR2 (corticotropin releasing hormone receptor 2 [Source:HGNC Symbol;Acc:HGNC:2358]) HSP 1 Score: 160.999 bits (406), Expect = 1.742e-43 Identity = 114/374 (30.48%), Postives = 184/374 (49.20%), Query Frame = 3
Query: 192 EYCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC---VNGRHEEINL---VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC D + CWP + AG PCP F+G +Y++ NA R+C +G+W A+K NY+ C ++ + + +L + + ++ G+ +S+ L +A LF ++++C RN IH +L + FILR+ + +L ++ H + + + + + F WM +EG YL I TY RLR F IGW P + A + ++ W + +DY PII +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR VR R W++
Sbjct: 38 SYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTW-ASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQD 379
BLAST of corticotropin-releasing factor receptor vs. Ensembl Celegans
Match: pdfr-1 (Calcitonin receptor-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q09460]) HSP 1 Score: 89.3521 bits (220), Expect = 1.032e-18 Identity = 100/417 (23.98%), Postives = 162/417 (38.85%), Query Frame = 3
Query: 141 CRKEHFNRSLFYQDNNIE---YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEI--------NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII------------TPSGHPLRILQIV----LMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL-------WMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARR---PLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK-----VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C+K + +LF + + + +C A +D V+CWPPT A L CPH G D N ++C G W K +N+ C +E+ N + G LS++ L A+ +F +F+ L+ RN +H HL A ++ LVL+I + G + + IV F WM +EG+YL I + + + + I G+G P+ T L + + ++ + D P + L++N + +I L K+R G++KSVK A ++L+PLLG I+ + P V ++TY + QG MVA IYCF N EV +++
Sbjct: 52 CKKMLDHNNLFPERDPNDTRIWCNATYDTVLCWPPTPANSSVTLQCPH-MKGL--DPNKYIVKRCDETGRWAGKKPGHYENPWGWTNFTVCFKIDYEDAKIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVVILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIVFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRESNNTSEAGLKKSVK----------------------------------AAMMLLPLLGVPNIMQTIPFAPTRDNIMVFAVWTYTASFTYMYQGLMVASIYCFTNKEVNHVLK 431
BLAST of corticotropin-releasing factor receptor vs. Ensembl Celegans
Match: pdfr-1 (Calcitonin receptor-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q09460]) HSP 1 Score: 89.3521 bits (220), Expect = 1.032e-18 Identity = 100/417 (23.98%), Postives = 162/417 (38.85%), Query Frame = 3
Query: 141 CRKEHFNRSLFYQDNNIE---YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEI--------NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII------------TPSGHPLRILQIV----LMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL-------WMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARR---PLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK-----VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C+K + +LF + + + +C A +D V+CWPPT A L CPH G D N ++C G W K +N+ C +E+ N + G LS++ L A+ +F +F+ L+ RN +H HL A ++ LVL+I + G + + IV F WM +EG+YL I + + + + I G+G P+ T L + + ++ + D P + L++N + +I L K+R G++KSVK A ++L+PLLG I+ + P V ++TY + QG MVA IYCF N EV +++
Sbjct: 52 CKKMLDHNNLFPERDPNDTRIWCNATYDTVLCWPPTPANSSVTLQCPH-MKGL--DPNKYIVKRCDETGRWAGKKPGHYENPWGWTNFTVCFKIDYEDAKIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVVILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIVFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRESNNTSEAGLKKSVK----------------------------------AAMMLLPLLGVPNIMQTIPFAPTRDNIMVFAVWTYTASFTYMYQGLMVASIYCFTNKEVNHVLK 431
BLAST of corticotropin-releasing factor receptor vs. Ensembl Celegans
Match: pdfr-1 (Calcitonin receptor-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q09460]) HSP 1 Score: 89.3521 bits (220), Expect = 1.200e-18 Identity = 100/417 (23.98%), Postives = 162/417 (38.85%), Query Frame = 3
Query: 141 CRKEHFNRSLFYQDNNIE---YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEI--------NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII------------TPSGHPLRILQIV----LMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL-------WMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARR---PLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK-----VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C+K + +LF + + + +C A +D V+CWPPT A L CPH G D N ++C G W K +N+ C +E+ N + G LS++ L A+ +F +F+ L+ RN +H HL A ++ LVL+I + G + + IV F WM +EG+YL I + + + + I G+G P+ T L + + ++ + D P + L++N + +I L K+R G++KSVK A ++L+PLLG I+ + P V ++TY + QG MVA IYCF N EV +++
Sbjct: 52 CKKMLDHNNLFPERDPNDTRIWCNATYDTVLCWPPTPANSSVTLQCPH-MKGL--DPNKYIVKRCDETGRWAGKKPGHYENPWGWTNFTVCFKIDYEDAKIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVVILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIVFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRESNNTSEAGLKKSVK----------------------------------AAMMLLPLLGVPNIMQTIPFAPTRDNIMVFAVWTYTASFTYMYQGLMVASIYCFTNKEVNHVLK 431
BLAST of corticotropin-releasing factor receptor vs. Ensembl Celegans
Match: pdfr-1 (Calcitonin receptor-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q09460]) HSP 1 Score: 89.3521 bits (220), Expect = 1.200e-18 Identity = 100/417 (23.98%), Postives = 162/417 (38.85%), Query Frame = 3
Query: 141 CRKEHFNRSLFYQDNNIE---YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEI--------NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII------------TPSGHPLRILQIV----LMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL-------WMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARR---PLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK-----VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C+K + +LF + + + +C A +D V+CWPPT A L CPH G D N ++C G W K +N+ C +E+ N + G LS++ L A+ +F +F+ L+ RN +H HL A ++ LVL+I + G + + IV F WM +EG+YL I + + + + I G+G P+ T L + + ++ + D P + L++N + +I L K+R G++KSVK A ++L+PLLG I+ + P V ++TY + QG MVA IYCF N EV +++
Sbjct: 52 CKKMLDHNNLFPERDPNDTRIWCNATYDTVLCWPPTPANSSVTLQCPH-MKGL--DPNKYIVKRCDETGRWAGKKPGHYENPWGWTNFTVCFKIDYEDAKIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVVILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIVFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRESNNTSEAGLKKSVK----------------------------------AAMMLLPLLGVPNIMQTIPFAPTRDNIMVFAVWTYTASFTYMYQGLMVASIYCFTNKEVNHVLK 431
BLAST of corticotropin-releasing factor receptor vs. Ensembl Celegans
Match: pdfr-1 (Calcitonin receptor-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q09460]) HSP 1 Score: 88.9669 bits (219), Expect = 1.565e-18 Identity = 100/417 (23.98%), Postives = 162/417 (38.85%), Query Frame = 3
Query: 141 CRKEHFNRSLFYQDNNIE---YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEI--------NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII------------TPSGHPLRILQIV----LMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL-------WMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARR---PLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK-----VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C+K + +LF + + + +C A +D V+CWPPT A L CPH G D N ++C G W K +N+ C +E+ N + G LS++ L A+ +F +F+ L+ RN +H HL A ++ LVL+I + G + + IV F WM +EG+YL I + + + + I G+G P+ T L + + ++ + D P + L++N + +I L K+R G++KSVK A ++L+PLLG I+ + P V ++TY + QG MVA IYCF N EV +++
Sbjct: 52 CKKMLDHNNLFPERDPNDTRIWCNATYDTVLCWPPTPANSSVTLQCPH-MKGL--DPNKYIVKRCDETGRWAGKKPGHYENPWGWTNFTVCFKIDYEDAKIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVVILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIVFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRESNNTSEAGLKKSVK----------------------------------AAMMLLPLLGVPNIMQTIPFAPTRDNIMVFAVWTYTASFTYMYQGLMVASIYCFTNKEVNHVLK 431
BLAST of corticotropin-releasing factor receptor vs. Ensembl Fly
Match: Dh44-R2 (gene:FBgn0033744 transcript:FBtr0087936) HSP 1 Score: 169.474 bits (428), Expect = 1.731e-46 Identity = 125/385 (32.47%), Postives = 181/385 (47.01%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC---------VNGRHEEINLVG-VFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASF---LVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHD------------LWMRQ--LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKV-KFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C + FD V+CWP T AG A+LPC F G YD+ DNATR C +G+W + S+Y+ C V + L ++ GY LS L AL +F FK L+C RN IH +LF +I + + L L +IT + +V+M +L F WM +EGLYL+ L+ T+ + +A+IGWG P ++ F +PH WMR+ +D+ +P L++N + ++ I+ L+ KLR+ L + +Y KA KA LVL+PL G Y++ +T + + LF + A STQGF VAL YCF N EVR+ +R WRE N
Sbjct: 84 CPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWD-HYSDYDRCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQVITTESSQAGCITLVIMFQYF-YLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAF-APHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETR-------------------------------QYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRN 434
BLAST of corticotropin-releasing factor receptor vs. Ensembl Fly
Match: Dh44-R2 (gene:FBgn0033744 transcript:FBtr0113075) HSP 1 Score: 169.474 bits (428), Expect = 1.799e-46 Identity = 125/385 (32.47%), Postives = 181/385 (47.01%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC---------VNGRHEEINLVG-VFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASF---LVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHD------------LWMRQ--LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKV-KFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C + FD V+CWP T AG A+LPC F G YD+ DNATR C +G+W + S+Y+ C V + L ++ GY LS L AL +F FK L+C RN IH +LF +I + + L L +IT + +V+M +L F WM +EGLYL+ L+ T+ + +A+IGWG P ++ F +PH WMR+ +D+ +P L++N + ++ I+ L+ KLR+ L + +Y KA KA LVL+PL G Y++ +T + + LF + A STQGF VAL YCF N EVR+ +R WRE N
Sbjct: 84 CPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWD-HYSDYDRCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQVITTESSQAGCITLVIMFQYF-YLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAF-APHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETR-------------------------------QYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRN 434
BLAST of corticotropin-releasing factor receptor vs. Ensembl Fly
Match: Dh44-R1 (gene:FBgn0033932 transcript:FBtr0087485) HSP 1 Score: 160.999 bits (406), Expect = 4.444e-43 Identity = 130/416 (31.25%), Postives = 199/416 (47.84%), Query Frame = 3
Query: 87 MLNTSNFNFLGTINRRQNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN-GRHEEINLVGVFIS--------GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAH---LAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFP----MALTSANTLYNIFTSPHDL-----WMRQ--LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
+L+ N + +G Q +EH S + D+ +C FD ++CWP T G A+L C G YDS+ NATR C +G+W +NY++C + E + V + GY LS++ L AL +F +FK L+C RN IH +LF +I+ SA F +L + + + +I+ L H L F WML+EGLYL+ L+ T+ LR +A IGWG P + A +L +++P WM++ +D+ P+ +LI+N +L I+ L+ KLR+ + + +YRKA KA LVL+PL G Y++ + + +F L A+ STQGF V+L YCF N EVR +R + WR+
Sbjct: 18 LLDLHNLDGIGESVELQCLVQEHIEASTYGNDSG--HCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTW-EKYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIM-SALFWILLLSVQISIRSGVGSCIALIT-LFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETR-------------------------------QYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRD 397
BLAST of corticotropin-releasing factor receptor vs. Ensembl Fly
Match: Pdfr (gene:FBgn0260753 transcript:FBtr0070436) HSP 1 Score: 108.612 bits (270), Expect = 1.220e-24 Identity = 104/399 (26.07%), Postives = 171/399 (42.86%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEINLV-------------------GVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII--------TPSGHPLRIL-------QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSA----NTLYNIFTSPHDLWMRQLD---YFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIF-ITHYHPKVKF-LFTYLNAMFTSTQGFMVALIYCFQNIEVRKLV 1232
YC +D ++CWPPT AG A + CP F G D+ A R+C DG W + ++Y C + E I L+ + I G LS+ L +L +FC F++L+ R IH +LF A +L+ L L++ + L ++ + ++ A A+F WM IEGLYL ++ + F+ +GW P+ +T+ +Y + LW L + + P + ++++N ++ II LV+KLR + I+++ RKA++A +VL+PLLG ++ + F +++Y TS QGF +ALIYCF N EVR ++
Sbjct: 146 YCNWTWDTLLCWPPTPAGVLARMNCPGGFHGV--DTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCY--KPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQT-------------------------------RKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVL 509
BLAST of corticotropin-releasing factor receptor vs. Ensembl Fly
Match: Pdfr (gene:FBgn0260753 transcript:FBtr0308565) HSP 1 Score: 108.612 bits (270), Expect = 1.377e-24 Identity = 104/399 (26.07%), Postives = 171/399 (42.86%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANK----------SNYNSCVNGRHEEINLV-------------------GVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFII--------TPSGHPLRIL-------QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSA----NTLYNIFTSPHDLWMRQLD---YFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIF-ITHYHPKVKF-LFTYLNAMFTSTQGFMVALIYCFQNIEVRKLV 1232
YC +D ++CWPPT AG A + CP F G D+ A R+C DG W + ++Y C + E I L+ + I G LS+ L +L +FC F++L+ R IH +LF A +L+ L L++ + L ++ + ++ A A+F WM IEGLYL ++ + F+ +GW P+ +T+ +Y + LW L + + P + ++++N ++ II LV+KLR + I+++ RKA++A +VL+PLLG ++ + F +++Y TS QGF +ALIYCF N EVR ++
Sbjct: 215 YCNWTWDTLLCWPPTPAGVLARMNCPGGFHGV--DTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCY--KPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQT-------------------------------RKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVL 578
BLAST of corticotropin-releasing factor receptor vs. Ensembl Zebrafish
Match: crhr1 (corticotropin releasing hormone receptor 1 [Source:ZFIN;Acc:ZDB-GENE-081231-1]) HSP 1 Score: 171.4 bits (433), Expect = 1.899e-47 Identity = 122/376 (32.45%), Postives = 185/376 (49.20%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
+C DG+ CWP + AGE PCP +F G Y++ +N R+C +G+W A K NY+ C +EE + V I+ G+ +S+ L A LF ++++C RN IH +L +AFILR+A+ F+V + P H ++ ++V H+ F WM EG YL I TY +LR F IGW P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR VR R W++ ++
Sbjct: 58 FCNTSIDGIGTCWPRSSAGEVVSRPCPESFLGVRYNTTNNVYRECLANGTW-AKKGNYSQCQEILNEEKKSKLHYHIAVIINYLGHCISLGALLVAFILFMRLRSIRCLRNIIHWNLITAFILRNATWFVVQLTMNPEVHESNVIWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKRAGIYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEISQIVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHS 401
BLAST of corticotropin-releasing factor receptor vs. Ensembl Zebrafish
Match: pth3r (parathyroid hormone 3 receptor [Source:ZFIN;Acc:ZDB-GENE-991123-12]) HSP 1 Score: 138.658 bits (348), Expect = 8.234e-35 Identity = 114/405 (28.15%), Postives = 183/405 (45.19%), Query Frame = 3
Query: 123 INRRQNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTA------NKSNYNSCVNGRH------EEI--NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFL----VLFIITPSGH-PLRILQIVLMISRLAHLAIF--------HWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLW---MRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF----TYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
I R C + +S ++NN C +DG++CWP + + + CP ++++ A R C G+W +NY C H EE+ L ++ GY++S+ L A+ + C+FK L CTRN+IH HLF++FI R+ S VL+ +T G ++ M+ A + +F +W+L+EGLYL LI+ + + IIGWG P S + + W L + +PI+ +++N + L II L KL + + + + P Q +YRK +K+T+VLMPL G +Y++F+ + V L + +F S+QGF VA IYCF N EV+ V+
Sbjct: 39 IGARSRCERTIRAQSDVVRENN---CAPEWDGIICWPTGKPNQMVAVLCPEYI--YDFNHRGYAYRHCDASGNWEQVSIINRTWANYTECTTYLHTNHSDQEEVFERLYLMYTIGYSISLAALLVAVSILCYFKRLHCTRNYIHIHLFTSFICRAISIFVKDAVLYAVTNDGELEDGAVEQRPMVGCKAAVTLFLYLLATNHYWILVEGLYLHSLIFMAFLSDKNCLWALTIIGWGIPAVFVSIWVSARVSLADTQCWDISAGNLKWIYQVPILAAIVVNFFLFLNIIRVLASKLW-------ETNTGKLD-PRQ--------------------QYRKLLKSTMVLMPLFGVHYMLFMALPYTDVTGLLWQIQMHYEMLFNSSQGFFVAFIYCFCNGEVQAEVK 410
BLAST of corticotropin-releasing factor receptor vs. Ensembl Zebrafish
Match: pth1r (parathyroid hormone 1 receptor [Source:ZFIN;Acc:ZDB-GENE-991123-8]) HSP 1 Score: 136.732 bits (343), Expect = 2.588e-34 Identity = 115/397 (28.97%), Postives = 183/397 (46.10%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWT----ANKS--NYNSCV--------NGRHEEIN-LVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQ---------------------------IVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSA-----NTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF----TYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C +DG++CWP G+ CP ++++ +A R+C +G+W NK+ NY+ C N E + L ++ GY++S+ L A + +F+ L CTRN+IH HLF +F+LR+ S V ++ SG L+ ++ + L + LA ++W+L+EGLYL LI+ T+ R F +IGWG P + TL + T DL L + IPI+T +++N ++ L II L KLR ++ C+ +YRK +K+TLVLMPL G +YI+F+ + +V + + +F S QGF VA+IYCF N EV+ ++
Sbjct: 38 CLPEWDGILCWPEGVPGKMVSTSCPEYI--YDFNHKGHAYRRCDLNGTWELASHNNKTWANYSECAKFFPHYNQNQEREVFDRLYLIYTVGYSISLGSLMVATVILGYFRRLHCTRNYIHMHLFLSFMLRAISIFVKDVVLYSGSALQEMERITVEDLKSITEAPPANKTQFIGCKVAVTLFLYFLA--TNYYWILVEGLYLHSLIFMTFFSDRKYLWGFTLIGWGVPAMFVTIWASVRATLAD--TECWDLSAGNLKWIVQIPILTAIVVNFLLFLNIIRVLATKLR-----------------ETNAGRCDTRQ-----------QYRKLLKSTLVLMPLFGVHYIVFMAMPYTEVSGVLWQIQMHYEMLFNSVQGFFVAIIYCFCNGEVQAEIK 400
BLAST of corticotropin-releasing factor receptor vs. Ensembl Zebrafish
Match: pth1r (parathyroid hormone 1 receptor [Source:ZFIN;Acc:ZDB-GENE-991123-8]) HSP 1 Score: 136.732 bits (343), Expect = 3.123e-34 Identity = 115/397 (28.97%), Postives = 183/397 (46.10%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTA----NKS--NYNSCV--------NGRHEEIN-LVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQ---------------------------IVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSA-----NTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF----TYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C +DG++CWP G+ CP ++++ +A R+C +G+W NK+ NY+ C N E + L ++ GY++S+ L A + +F+ L CTRN+IH HLF +F+LR+ S V ++ SG L+ ++ + L + LA ++W+L+EGLYL LI+ T+ R F +IGWG P + TL + T DL L + IPI+T +++N ++ L II L KLR ++ C+ +YRK +K+TLVLMPL G +YI+F+ + +V + + +F S QGF VA+IYCF N EV+ ++
Sbjct: 63 CLPEWDGILCWPEGVPGKMVSTSCPEYI--YDFNHKGHAYRRCDLNGTWELASHNNKTWANYSECAKFFPHYNQNQEREVFDRLYLIYTVGYSISLGSLMVATVILGYFRRLHCTRNYIHMHLFLSFMLRAISIFVKDVVLYSGSALQEMERITVEDLKSITEAPPANKTQFIGCKVAVTLFLYFLA--TNYYWILVEGLYLHSLIFMTFFSDRKYLWGFTLIGWGVPAMFVTIWASVRATLAD--TECWDLSAGNLKWIVQIPILTAIVVNFLLFLNIIRVLATKLR-----------------ETNAGRCDTRQ-----------QYRKLLKSTLVLMPLFGVHYIVFMAMPYTEVSGVLWQIQMHYEMLFNSVQGFFVAIIYCFCNGEVQAEIK 425
BLAST of corticotropin-releasing factor receptor vs. Ensembl Zebrafish
Match: ghrhr2 (growth hormone releasing hormone receptor 2 [Source:ZFIN;Acc:ZDB-GENE-121214-194]) HSP 1 Score: 134.035 bits (336), Expect = 4.464e-34 Identity = 105/372 (28.23%), Postives = 173/372 (46.51%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVG-----------VFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFL----VLFIITPSGH---PLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLD--YFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFI---THYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRL 1244
C +DGV CWP GE+ + CP S++ +R C++ G + Y +C E +G ++ GY +S+ LC A+F+FC F+ L CTR +IH +LFS FILR+ + VLF H + + + + L+ F+W+L+EGLYL L+ +T+ +R + ++GWG P + T + W LD ++ I I ++ + ++FI + ++ ++ + P DS+G +K RF YR+ K+TL+L+PL G +YI+F H + + F + F QGF+VAL+YCF N EV+ +R +
Sbjct: 52 CLVEWDGVNCWPAVSVGERVSVSCPPLLK-----SHELISRTCTSKGWSNMSVPYYTACFQDNSTEEEEIGHISEYFARVKLIYTVGYGMSLSSLCIAVFIFCIFRKLLCTRIYIHLNLFSTFILRALAVFVKDAVLFADETVNHCTVSTVLCKASVTFFQYCVLSNFYWLLVEGLYLQTLLTFTFAHKRTFFWCYTLVGWGTPSVTVTIWTFLKYSYDDYGCW-DDLDSGFWWIIKIPILISVLVNFLMFINISRIIIVKTKTP---------------DSNGGDK---------RF---YRRLAKSTLLLIPLFGVHYIVFALFPEHVGLEARLFFELVLGSF---QGFIVALLYCFLNSEVQNEIRKEI 387
BLAST of corticotropin-releasing factor receptor vs. Ensembl Xenopus
Match: yif1b (Yip1 interacting factor homolog B, membrane trafficking protein [Source:Xenbase;Acc:XB-GENE-922881]) HSP 1 Score: 165.236 bits (417), Expect = 2.099e-45 Identity = 120/385 (31.17%), Postives = 188/385 (48.83%), Query Frame = 3
Query: 165 SLFYQDNNIEYCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGVFIS------GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVL-FIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYII-FITHYHPKV-KFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
SL NN C A D + CWP T AG+ PCP F G +Y++ N R+C +GSW A + +Y C +E V I+ G+++S+ L A LF ++++C RN IH +L +AFILR+ ++ V+ ++ H ++ ++V + ++ F WM EG YL I TY +LR F IGW P + A + ++ W + D+ P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++ F+T ++ + +F Y N+ S QGF V++ YCF N EVR VR R W++ ++
Sbjct: 6 SLHLLSNNCLACNASIDMIGTCWPRTAAGQMVARPCPEYFQGVQYNTTGNVYRECHLNGSW-AGRGDYTQCQEILKQEKTKVHYHIAIVINFLGHSISLCALLVAFILFLRLRSIRCLRNIIHWNLITAFILRNVTWFVMQLTLSHEAHDSNVVWCRLVTIAHNYFYVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKKAGVYTDFIYQGPVILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVTPGEDEISRVVFIYFNSFLQSFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHS 358
BLAST of corticotropin-releasing factor receptor vs. Ensembl Xenopus
Match: yif1b (Yip1 interacting factor homolog B, membrane trafficking protein [Source:Xenbase;Acc:XB-GENE-922881]) HSP 1 Score: 161.77 bits (408), Expect = 8.583e-44 Identity = 116/374 (31.02%), Postives = 184/374 (49.20%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGVFIS------GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVL-FIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYII-FITHYHPKV-KFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP T AG+ PCP F G +Y++ N R+C +GSW A + +Y C +E V I+ G+++S+ L A LF ++++C RN IH +L +AFILR+ ++ V+ ++ H ++ ++V + ++ F WM EG YL I TY +LR F IGW P + A + ++ W + D+ P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++ F+T ++ + +F Y N+ S QGF V++ YCF N EVR VR R W++ ++
Sbjct: 56 CNASIDMIGTCWPRTAAGQMVARPCPEYFQGVQYNTTGNVYRECHLNGSW-AGRGDYTQCQEILKQEKTKVHYHIAIVINFLGHSISLCALLVAFILFLRLRSIRCLRNIIHWNLITAFILRNVTWFVMQLTLSHEAHDSNVVWCRLVTIAHNYFYVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKKAGVYTDFIYQGPVILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVTPGEDEISRVVFIYFNSFLQSFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHS 397
BLAST of corticotropin-releasing factor receptor vs. Ensembl Xenopus
Match: yif1b (Yip1 interacting factor homolog B, membrane trafficking protein [Source:Xenbase;Acc:XB-GENE-922881]) HSP 1 Score: 160.999 bits (406), Expect = 1.680e-43 Identity = 117/376 (31.12%), Postives = 186/376 (49.47%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEE--------INLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVL-FIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYII-FITHYHPKV-KFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP T AG+ PCP F G +Y++ N R+C +GSW A + +Y C +E I +V F+ G+++S+ L A LF ++++C RN IH +L +AFILR+ ++ V+ ++ H ++ ++V + ++ F WM EG YL I TY +LR F IGW P + A + ++ W + D+ P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++ F+T ++ + +F Y N+ S QGF V++ YCF N EVR VR R W++ ++
Sbjct: 44 CNASIDMIGTCWPRTAAGQMVARPCPEYFQGVQYNTTGNVYRECHLNGSW-AGRGDYTQCQEILKQEKKTKVHYHIAIVINFL-GHSISLCALLVAFILFLRLRSIRCLRNIIHWNLITAFILRNVTWFVMQLTLSHEAHDSNVVWCRLVTIAHNYFYVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKKAGVYTDFIYQGPVILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVTPGEDEISRVVFIYFNSFLQSFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Xenopus
Match: slc17a9 (solute carrier family 17 member 9 [Source:Xenbase;Acc:XB-GENE-5753894]) HSP 1 Score: 158.303 bits (399), Expect = 1.598e-42 Identity = 116/373 (31.10%), Postives = 183/373 (49.06%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCV----NGR----HEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC A D + CWP + AG PCP +F+G Y++ + TR+C +G+W A+ NY+ CV N R H +I L+ ++ G+ +S++ L A LF ++++C RN IH +L + FILR+ + +L +I H + + + + + F WM +EG YL I TY +LR F IGW P + + +F W+ + +DY P+I +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR R R W++
Sbjct: 42 YCSATIDQIGTCWPRSIAGGLVERPCPDSFNGIRYNTTRSVTRECFENGTW-ASWMNYSQCVPILDNKRKYALHYKIALIINYL-GHCISVLALVIAFLLFLCLRSIRCLRNIIHWNLITTFILRNIMWFLLQMIDHRIHESNEVWCRCITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPSPIIVTWAVCKLFYENEQCWIGKEPGKYIDYIYQGPVILVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDVSQIVFIYFNSFLQSFQGFFVSVFYCFLNGEVRSAARKRWHRWQD 381
BLAST of corticotropin-releasing factor receptor vs. Ensembl Xenopus
Match: slc17a9 (solute carrier family 17 member 9 [Source:Xenbase;Acc:XB-GENE-5753894]) HSP 1 Score: 157.918 bits (398), Expect = 1.732e-42 Identity = 116/373 (31.10%), Postives = 183/373 (49.06%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCV----NGR----HEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC A D + CWP + AG PCP +F+G Y++ + TR+C +G+W A+ NY+ CV N R H +I L+ ++ G+ +S++ L A LF ++++C RN IH +L + FILR+ + +L +I H + + + + + F WM +EG YL I TY +LR F IGW P + + +F W+ + +DY P+I +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR R R W++
Sbjct: 45 YCSATIDQIGTCWPRSIAGGLVERPCPDSFNGIRYNTTRSVTRECFENGTW-ASWMNYSQCVPILDNKRKYALHYKIALIINYL-GHCISVLALVIAFLLFLCLRSIRCLRNIIHWNLITTFILRNIMWFLLQMIDHRIHESNEVWCRCITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPSPIIVTWAVCKLFYENEQCWIGKEPGKYIDYIYQGPVILVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDVSQIVFIYFNSFLQSFQGFFVSVFYCFLNGEVRSAARKRWHRWQD 384
BLAST of corticotropin-releasing factor receptor vs. Ensembl Mouse
Match: Crhr1 (corticotropin releasing hormone receptor 1 [Source:MGI Symbol;Acc:MGI:88498]) HSP 1 Score: 174.481 bits (441), Expect = 1.143e-48 Identity = 123/375 (32.80%), Postives = 186/375 (49.60%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE + V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHIAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Mouse
Match: Crhr2 (corticotropin releasing hormone receptor 2 [Source:MGI Symbol;Acc:MGI:894312]) HSP 1 Score: 155.992 bits (393), Expect = 8.205e-42 Identity = 109/373 (29.22%), Postives = 184/373 (49.33%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC---VNGRHEEINL---VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC D + CWP + G PCP F+G +Y++ NA R+C +G+W A++ NY+ C ++ + + +L + + ++ G+ +S++ L +A LF ++++C RN IH +L + FILR+ ++ +L +I H + + + + + F WM +EG YL I TY LR F IGW P + A + ++ W + +DY P++ +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++
Sbjct: 39 YCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTW-ASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQD 379
BLAST of corticotropin-releasing factor receptor vs. Ensembl Mouse
Match: Crhr2 (corticotropin releasing hormone receptor 2 [Source:MGI Symbol;Acc:MGI:894312]) HSP 1 Score: 155.992 bits (393), Expect = 8.940e-42 Identity = 109/373 (29.22%), Postives = 184/373 (49.33%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC---VNGRHEEINL---VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC D + CWP + G PCP F+G +Y++ NA R+C +G+W A++ NY+ C ++ + + +L + + ++ G+ +S++ L +A LF ++++C RN IH +L + FILR+ ++ +L +I H + + + + + F WM +EG YL I TY LR F IGW P + A + ++ W + +DY P++ +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++
Sbjct: 59 YCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTW-ASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQD 399
BLAST of corticotropin-releasing factor receptor vs. Ensembl Mouse
Match: Crhr2 (corticotropin releasing hormone receptor 2 [Source:MGI Symbol;Acc:MGI:894312]) HSP 1 Score: 155.221 bits (391), Expect = 1.446e-41 Identity = 111/373 (29.76%), Postives = 180/373 (48.26%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN--------GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC D + CWP + G PCP F+G +Y++ NA R+C +G+W A++ NY+ C H I L+ ++ G+ +S++ L +A LF ++++C RN IH +L + FILR+ ++ +L +I H + + + + + F WM +EG YL I TY LR F IGW P + A + ++ W + +DY P++ +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++
Sbjct: 39 YCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTW-ASRVNYSHCEPILDDKRKYDLHYRIALIVNYL-GHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQD 378
BLAST of corticotropin-releasing factor receptor vs. Ensembl Mouse
Match: Crhr2 (corticotropin releasing hormone receptor 2 [Source:MGI Symbol;Acc:MGI:894312]) HSP 1 Score: 155.606 bits (392), Expect = 1.482e-41 Identity = 111/373 (29.76%), Postives = 180/373 (48.26%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN--------GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
YC D + CWP + G PCP F+G +Y++ NA R+C +G+W A++ NY+ C H I L+ ++ G+ +S++ L +A LF ++++C RN IH +L + FILR+ ++ +L +I H + + + + + F WM +EG YL I TY LR F IGW P + A + ++ W + +DY P++ +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++
Sbjct: 59 YCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTW-ASRVNYSHCEPILDDKRKYDLHYRIALIVNYL-GHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQD 398
BLAST of corticotropin-releasing factor receptor vs. UniProt/SwissProt
Match: sp|P35347|CRFR1_MOUSE (Corticotropin-releasing factor receptor 1 OS=Mus musculus OX=10090 GN=Crhr1 PE=1 SV=1) HSP 1 Score: 174.481 bits (441), Expect = 7.992e-48 Identity = 123/375 (32.80%), Postives = 186/375 (49.60%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE + V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHIAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. UniProt/SwissProt
Match: sp|P35353|CRFR1_RAT (Corticotropin-releasing factor receptor 1 OS=Rattus norvegicus OX=10116 GN=Crhr1 PE=1 SV=1) HSP 1 Score: 173.326 bits (438), Expect = 1.974e-47 Identity = 124/375 (33.07%), Postives = 185/375 (49.33%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE V V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + + W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. UniProt/SwissProt
Match: sp|Q76LL8|CRFR1_MACMU (Corticotropin-releasing factor receptor 1 OS=Macaca mulatta OX=9544 GN=CRHR1 PE=2 SV=1) HSP 1 Score: 173.326 bits (438), Expect = 2.424e-47 Identity = 124/375 (33.07%), Postives = 186/375 (49.60%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRI--LQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C A D + CWP + AG+ + PCP F G Y++ +N R+C +GSW A + NY+ C +EE V V I+ G+ +S++ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V H+ F WM EG YL I TY RLR F IGWG P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR +R R W++ ++
Sbjct: 44 CNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAA-RVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHS 386
BLAST of corticotropin-releasing factor receptor vs. UniProt/SwissProt
Match: sp|P35464|DIHR_MANSE (Diuretic hormone receptor OS=Manduca sexta OX=7130 PE=2 SV=1) HSP 1 Score: 168.703 bits (426), Expect = 8.352e-46 Identity = 126/402 (31.34%), Postives = 187/402 (46.52%), Query Frame = 3
Query: 135 QNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC----VNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLA----HLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIF------TSPHDL----------WM--RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKF--LFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWR 1256
+ C FN S DN YC A FDG++CW PT A+ C G +YD NA+R C DG W N +NY +C NG ++ + ++++GY+LS+ L A+F+F +FK L+C RN IH +L S +IL + S+++ ++ + Q MI + +L F WML+EGLYL+ L+ T+ ++ + + IGWG P + + F T P L WM Q+D+ P + L +N ++ I+ L+ KLR+ L + +YRKA KA LVL+PLLG ++ + F F Y A+ STQGF VAL YCF N EVR +R + W+
Sbjct: 3 EECLARKFNLS----DN---YCPAYFDGLLCWDPTPWNTLAVQKCFKELYGIQYDDTQNASRLC-LDGVW-HNYTNYTNCTERIANGSPTDVASL-IYLAGYSLSLAVLSLAVFVFLYFKDLRCLRNTIHTNLMSTYILSACSWILNLVLQNWSDESQQDQTSCMILVICMNYFYLTNFFWMLVEGLYLYMLVVETFTAENIKLKVYTTIGWGAPAVFITIWVISRCFVNVLPSTGPDGLAMFPEAKMCIWMHEHQVDWIHKAPALVGLALNLFFLIRIMWVLITKLRSANTLETE-------------------------------QYRKATKALLVLIPLLGITNLLVLCGPSDDSWFAYAFDYTRALMLSTQGFTVALFYCFMNTEVRHAIRYHVERWK 363
BLAST of corticotropin-releasing factor receptor vs. UniProt/SwissProt
Match: sp|Q16983|DIHR_ACHDO (Diuretic hormone receptor OS=Acheta domesticus OX=6997 PE=2 SV=1) HSP 1 Score: 169.088 bits (427), Expect = 1.292e-45 Identity = 120/404 (29.70%), Postives = 190/404 (47.03%), Query Frame = 3
Query: 120 TINRRQNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN----GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFP--MALTSANTLYNIFTSP--------------HDLWMRQLDYFTDXXXXXXXXXXXXXMLF---IIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVK-FLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWRE 1259
T+ R++ C + + C +DGV CWP T AG A+ PC +G YD NATR C ++G+W N S+Y C E+ + VF G+ LS++ + A+++F +FK L+C RN IH +L + +I A++++ ++ + ++ ++ +L F WM +EGLYLF L+ T+ +++ + + IIGWG P + +T A + T+P H WM + DYF I ++ + ++ ++F I+ L+ KL++ Q +YRKA KA LVL PLLG YI+ + V +F A+ S QGF VAL YCF N EV+ +R R+ WRE
Sbjct: 36 TLQRQRACEALMEGDAPDAAPDAPLRCAIAWDGVNCWPETPAGALAVQPCFDELNGIRYDIRQNATRMCYSNGTWR-NYSDYVHCRELVEAESDEDAAMAFVFFVGFCLSLVAIAVAIWIFLYFKDLRCLRNTIHTNLMATYICNDATWIISAVVQEYVENGGLCSVLAVLMHYFYLTNFFWMFVEGLYLFLLVVATFTGEKVKLQIYIIIGWGIPGVIVVTWAIIKHLGKTAPDNAGESHPMVLLIKHCPWMAE-DYFDWIHQAPVITVLAVNLVFLFSIMWVLITKLQSANTAETQ-------------------------------QYRKATKALLVLFPLLGITYILMMQGPMDGVAGHVFRNAQALLLSLQGFTVALFYCFLNTEVQNTLRHRMSRWRE 406
BLAST of corticotropin-releasing factor receptor vs. TrEMBL
Match: H9N4T0 (Corticotropin-releasing factor receptor (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 357.451 bits (916), Expect = 6.180e-119 Identity = 187/187 (100.00%), Postives = 187/187 (100.00%), Query Frame = 3
Query: 582 GHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF 1142
GHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDIPIITILIMNSIIMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF
Sbjct: 1 GHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDIPIITILIMNSIIMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF 187
BLAST of corticotropin-releasing factor receptor vs. TrEMBL
Match: X2BBW7 (Uncharacterized protein OS=Capitella teleta OX=283909 PE=3 SV=1) HSP 1 Score: 192.2 bits (487), Expect = 1.248e-51 Identity = 124/383 (32.38%), Postives = 191/383 (49.87%), Query Frame = 3
Query: 174 YQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC-----VNGRHEEINLVG--VFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLR-------ILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREG 1262
+ D YC + +D V CWP T AG+ A+L CP F+ D N NATR C +G+W +S+Y+ C VN + N + ++ G+ SI+ L AL +F +F++L+C RN IHCHL FI + +L++ + P + +I++ + +A F WML+EGLYL +I W + + R+R ++A++GW P + A + W+ DY PI+ +L++N I + I+ L+ KLRA L + +YRKA++ATL+L PLLG Y++FI+ + K F Y NA+ S QG +A+ YCF N EVR +RGR+ W+EG
Sbjct: 2 FTDAGQLYCNSTWDTVSCWPTTPAGQLAVLTCPPRFEEVLLDPNGNATRMCYPNGTWQF-RSDYDHCKPITMVNKEEDIHNFITRVIYYVGFTTSIVALIVALCIFLYFRSLRCLRNTIHCHLIVTFIFKYILWLIMNNVLPKLTDDDHNEIHQWVCKIIVALYNYIQVANFFWMLVEGLYLHTMIVWAFSIERIRFWYYAVLGWCGPALVVLAWAIVKAKFENRRCWLPMENSSYDYIYITPILGVLLVNVIFLGSIVWVLITKLRASNTLQAR-------------------------------QYRKAVRATLILFPLLGVTYVVFISPPNDGALAKRAFVYFNAILQSLQGLAIAVFYCFLNGEVRSTIRGRVSRWQEG 352
BLAST of corticotropin-releasing factor receptor vs. TrEMBL
Match: A0A411JKC8 (DH44 receptor OS=Aedes aegypti OX=7159 GN=AAEL008287 PE=2 SV=1) HSP 1 Score: 190.66 bits (483), Expect = 6.172e-51 Identity = 127/379 (33.51%), Postives = 192/379 (50.66%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGV----FISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL-------------WMRQ--LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKV-KFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
C FD ++CWP T + A+LPC F G YD+ NATR C +DG W N S+Y +C + ++V V + SGY +S++ L A+ +F +FK L+C RN IH +LF +IL + ++++ + SG I V++++ L + + F WML+EGLYL+ L+ T+ LR ++IIGWG P+ A + F P+DL WMR+ +D+ P +L++N I +L I+ L+ KLR+ + + +YRKA KA LVL+PLLG Y++ I H V +F A+ STQG +V+L+YCF N EVR +R WR+ N
Sbjct: 69 CPVNFDSILCWPKTPSNTWAVLPCFKEFKGVAYDARQNATRYCHSDGKWD-NYSHYTACHHMTEPPPDIVEVTSIIYYSGYIVSLVALSLAVIVFVYFKDLRCLRNTIHANLFITYILSALMWIIILTLQLSGSQSGIASCVILVTLLHYFTLTNFFWMLVEGLYLYMLVVQTFSGDYLRFWKYSIIGWGGPLIFVGAWAIAKSFY-PYDLMPEHPNKLEIECSWMRESHIDWIIQGPSCAVLVINLIFLLRIMWVLITKLRSANTVETR-------------------------------QYRKASKALLVLIPLLGITYLVVIYGPHEGVGSRIFAVTRAVLLSTQGLVVSLLYCFLNYEVRGTLRLHYYRWRDERN 414
BLAST of corticotropin-releasing factor receptor vs. TrEMBL
Match: A0A2U9PG90 (Neuropeptide receptor OS=Diaphorina citri OX=121845 PE=2 SV=1) HSP 1 Score: 188.348 bits (477), Expect = 1.786e-50 Identity = 125/407 (30.71%), Postives = 199/407 (48.89%), Query Frame = 3
Query: 126 NRRQNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRH--EEINLVGVFIS------GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDL--------------WMRQ--LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
++ C N S+ + + YC +D V+CWPPT+ G AILPC +G +YD++ NA++ C+ +GSW + +NY+ C + + ++++ G+ I+ GY LS+I L A+++F +FK L+C RN IH +L +IL +++ + S I+ + HL F WM +EGLYL+ L+ T+ ++ R + +IGWG P+ + + + F D+ WM D+ P I +L +N + ++ I+ L+ KLR+ + Q +YRKA KA +VL+PLLG YI+ I P V L+ +L A+ STQGF VAL YCF N EV+ +R L W+E N
Sbjct: 16 DKEYECLMNAANDSIVADPSKLHYCPRQWDQVLCWPPTKNGSLAILPCFGELNGIQYDTSQNASKWCNANGSWNS-FANYSLCTDIKKTTQDLSEPGIEITTMIYSVGYTLSLIALIIAVWIFVYFKDLRCLRNKIHTNLMCTYILADFMWILTMTVQMSVQSNFACVILYIFLHYCHLTNFFWMFVEGLYLYMLVVETFTRENIKLRVYFLIGWGAPLVIVTVWAIAKTFAPSSDIQSQGMGDIGLRHCPWMTPHVYDWIYQAPAILVLFINCLFLIMIMWVLITKLRSANTVETQ-------------------------------QYRKATKALVVLIPLLGITYILVIAGPTEGPYVS-LYAHLRAILLSTQGFTVALFYCFLNTEVQNTLRHHLERWKEARN 389
BLAST of corticotropin-releasing factor receptor vs. TrEMBL
Match: A0A0X3NV09 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=TR88651 PE=3 SV=1) HSP 1 Score: 191.43 bits (485), Expect = 2.860e-50 Identity = 103/263 (39.16%), Postives = 156/263 (59.32%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCV------NGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPS--GHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMR--QLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSV 953
+C +I+DGVMCWPP + PCP +F+G Y+S NATR+C +G W N++ Y++C+ R E I L ++ GY++S+I L +LF+F F+ L C RNFIH HL +LR +++ L+ T S + + I LA LA+ WM +EGL+L K++YWTYGL R+R H+A+ GWG P L A ++N P D+W++ Q YF +P + IL N I+++FI++AL+ +++ R P Q SV
Sbjct: 42 FCPSIYDGVMCWPPAKPNTIVNFPCPDSFEGATYNSQSNATRRCLANGVW-VNRTEYDNCIWTNTTTPDRDETIYLQTIYCVGYSISLISLLVSLFIFFRFRTLHCLRNFIHTHLMGTLVLRVIAWMTLYGNTSSVGNSTVYLYNATTAIQSLASLAMICWMFLEGLHLLKIVYWTYGLHRIRIWHYAVFGWGLPAVLIVAWAIFNAVQFPDDMWIQHSQEFYFISLPSLIILCCNVIVLVFILYALICRIK-RTPHEPQTSV 302 HSP 2 Score: 80.1073 bits (196), Expect = 4.309e-12 Identity = 40/77 (51.95%), Postives = 55/77 (71.43%), Query Frame = 3
Query: 1005 RMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
R++ + SR E K++KA L+L+PLLG ++FI YHP V+ +F Y+NA+ STQGF VALIYCF N EVR ++R
Sbjct: 450 RLANKFSR--SEPMKSLKACLMLIPLLGIPQVVFIVPYHPSVREVFNYINAILISTQGFWVALIYCFLNEEVRLVLR 524
BLAST of corticotropin-releasing factor receptor vs. Ensembl Cavefish
Match: ENSAMXT00000037591.1 (corticotropin releasing hormone receptor 1 [Source:NCBI gene;Acc:103036295]) HSP 1 Score: 169.088 bits (427), Expect = 1.281e-46 Identity = 125/396 (31.57%), Postives = 193/396 (48.74%), Query Frame = 3
Query: 159 NRSLFYQDNNIE--------YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC-----VNGRHEEINLVGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRI--LQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
NR+++ D + + +C DG+ CWP + AGE PCP G Y++ + R+C +G+W A+K NY+ C V + + + V I+ G+ LS+ L A LF ++++C RN IH +L SAFILR+A+ F+V ++P H + ++V + H+A F WM EG YL I TY RL+ F IGW P+ + A ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR VR R W++ ++
Sbjct: 35 NRTMYSVDPSTQADSNSSGVFCRTSIDGIGTCWPRSMAGEMVSRPCPELLYGVRYNTTNKIFRKCLANGTW-ASKGNYSQCKAILNVQRKSKLHYRIAVIINYMGHCLSLFTLLIAFTLFLRLRSIRCLRNIIHWNLISAFILRNATWFIVQLTMSPDVHESNVPWCRLVTTLYNYFHMANFFWMFGEGCYLHTAIVLTYSTDRLKKWMFICIGWCIPLPIIVAWAFGKLYYDNEKCWFGKRAGVYTDYIYQGPMILVLMINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSQIVFIYFNSFLQSFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHS 398
BLAST of corticotropin-releasing factor receptor vs. Ensembl Cavefish
Match: crhr1 (corticotropin-releasing factor receptor 1-like [Source:NCBI gene;Acc:103028117]) HSP 1 Score: 168.703 bits (426), Expect = 1.509e-46 Identity = 121/376 (32.18%), Postives = 185/376 (49.20%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINL-----VGVFIS--GYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSAS-FLVLFIITPSGHPLRIL--QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQ-----LDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
+C D + CWP + GE PCP TF G Y+S +N R+C +G+W A K++Y+ C+ +EE + V I+ G+ +S+ L A LF ++++C RN IH +L +AFILR+A+ F+V + P H ++ ++V H+ F WM EG YL I TY +LR F IGW P + A + ++ W + DY P+I +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR VR R W++ ++
Sbjct: 56 FCNIYTDAIGTCWPKSSVGEVISRPCPDTFHGVRYNSTNNVYRECLDNGTW-ARKADYSQCLEILNEEKKSKLHYHIAVIINYLGHCISLGALLVAFILFMRLRSIRCLRNIIHWNLITAFILRNATWFVVQLTMNPEVHESNVIWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKRAGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEISQIVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHS 399
BLAST of corticotropin-releasing factor receptor vs. Ensembl Cavefish
Match: ENSAMXT00000045916.1 (corticotropin-releasing factor receptor 2-like [Source:NCBI gene;Acc:107197140]) HSP 1 Score: 157.918 bits (398), Expect = 1.117e-42 Identity = 124/420 (29.52%), Postives = 200/420 (47.62%), Query Frame = 3
Query: 87 MLNTSNFN-FLGTINRRQNCRKEHFNRSLFYQDNNIE-------YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN--------GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
M++T+ F FLG NC + FYQ++++ YC A D + CWP + +G PCP +G +Y++ +A R+C +G+W A K NY+SC H +I L+ ++ G+ +S+ L A LF ++++C RN IH +L + FILR+ + +L +I + H L+ + + + F WM +EG YL I TY +LR F IGW P + A + ++ W + +DY P+I +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N E+R R R W++ +
Sbjct: 1 MMDTTLFQLFLGEFGE-PNCSLMDAFQDTFYQNSSLTLMSLDGLYCNATTDEIGTCWPRSSSGRIVERPCPEYINGVKYNTTRSAYRECLENGTW-AFKINYSSCEPILEEKRKYPMHYKIALIINYL-GHCISVGALVVAFILFLCLRSIRCLRNVIHWNLITTFILRNVMWFLLQLIDHNIHERNEPWCRLITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPCPIIVAWAIGKLYNENEQCWFGKEPGKYIDYIYQGPVIVVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDISQIVFIYFNSFLQSFQGFFVSVFYCFLNGEIRSAARKRWHRWQDNHT 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Cavefish
Match: ENSAMXT00000058121.1 (corticotropin-releasing factor receptor 2-like [Source:NCBI gene;Acc:107197140]) HSP 1 Score: 152.14 bits (383), Expect = 1.559e-40 Identity = 113/376 (30.05%), Postives = 181/376 (48.14%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN--------GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
YC A D + CWP + +G PCP +G +Y++ +A R+C +G+W A K NY+SC H +I L+ ++ G+ +S+ L A LF ++++C RN IH +L + FILR+ + +L +I + H L+ + + + F WM +EG YL I TY +LR F IGW P + A + ++ W + +DY P+I +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N E+R R R W++ +
Sbjct: 44 YCNATTDEIGTCWPRSSSGRIVERPCPEYINGVKYNTTRSAYRECLENGTW-AFKINYSSCEPILEEKRKYPMHYKIALIINYL-GHCISVGALVVAFILFLCLRSIRCLRNVIHWNLITTFILRNVMWFLLQLIDHNIHERNEPWCRLITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPCPIIVAWAIGKLYNENEQCWFGKEPGKYIDYIYQGPVIVVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDISQIVFIYFNSFLQSFQGFFVSVFYCFLNGEIRSAARKRWHRWQDNHT 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Cavefish
Match: ENSAMXT00000034852.1 (corticotropin-releasing factor receptor 2-like [Source:NCBI gene;Acc:107197140]) HSP 1 Score: 152.14 bits (383), Expect = 1.559e-40 Identity = 113/376 (30.05%), Postives = 181/376 (48.14%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN--------GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYN 1268
YC A D + CWP + +G PCP +G +Y++ +A R+C +G+W A K NY+SC H +I L+ ++ G+ +S+ L A LF ++++C RN IH +L + FILR+ + +L +I + H L+ + + + F WM +EG YL I TY +LR F IGW P + A + ++ W + +DY P+I +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N E+R R R W++ +
Sbjct: 44 YCNATTDEIGTCWPRSSSGRIVERPCPEYINGVKYNTTRSAYRECLENGTW-AFKINYSSCEPILEEKRKYPMHYKIALIINYL-GHCISVGALVVAFILFLCLRSIRCLRNVIHWNLITTFILRNVMWFLLQLIDHNIHERNEPWCRLITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPCPIIVAWAIGKLYNENEQCWFGKEPGKYIDYIYQGPVIVVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDISQIVFIYFNSFLQSFQGFFVSVFYCFLNGEIRSAARKRWHRWQDNHT 386
BLAST of corticotropin-releasing factor receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004899.1 (pep scaffold:Pmarinus_7.0:GL476767:721819:758871:-1 gene:ENSPMAG00000004402.1 transcript:ENSPMAT00000004899.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 173.326 bits (438), Expect = 4.528e-49 Identity = 122/374 (32.62%), Postives = 185/374 (49.47%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCV--------NGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLR--ILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITH--YHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGY 1265
C A D + CWP + AG PCP F+G YDS+ + R+C +G+W A +SNY+ C N +H +I L+ ++ G+ +S+ L +A F ++++C RN IH HL + FILR+A++L+L II S ++V+ + + F WM +EG YL I TY +LR F IGW P + + +F W + +DY PII +L++N I + I+ L+ KLRA S ++T + S RKA+KATLVL+PLLG Y++F + P + +F Y+N+ S QGF V++ YCF N EVR +R R W + +
Sbjct: 42 CNATRDEIGTCWPESEAGRTVATPCPERFNGVRYDSSKSVIRECLANGTW-AQRSNYSLCKPIIDAKKPNSQHYKIALIVNYL-GHCISLAALITAFGFFWWLRSIRCLRNAIHWHLVTTFILRNAAWLLLQIIDLSTQERNEPWCRVVITVFNYFQVTNFFWMFVEGCYLHTAIVMTYSTDKLRKSIFVCIGWCIPAPIIIVWAMVKLFYEDEKCWFGKTEGKYIDYIYQGPIILVLLVNFIFLFNIVRILMTKLRA--------------------STTSETIQYS----------RKAVKATLVLLPLLGITYMLFFVNPGEDPVSQVIFIYVNSFLMSFQGFFVSVFYCFLNGEVRSALRKRWNRWMDNH 383
BLAST of corticotropin-releasing factor receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009958.1 (pep scaffold:Pmarinus_7.0:GL477206:37870:64312:-1 gene:ENSPMAG00000008983.1 transcript:ENSPMAT00000009958.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 154.451 bits (389), Expect = 2.128e-42 Identity = 116/374 (31.02%), Postives = 186/374 (49.73%), Query Frame = 3
Query: 195 YCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCV-------NGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGY 1265
+C A D + CWP + A I PCP F+G +YD++ + R+C D +W A +SNY+ C N +H ++ LV ++ G+ +S++ L +A +F ++++C RN IH +L + FILR+A++ +L +I S ++I+ + + F WM +EG YL I TY +LR F IGW P + + + W + +DY PII +L++N I + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y+N+ S QGF V++ YCF N EVR +R R W + +
Sbjct: 12 FCNATRDEIGTCWPSSEASRVVIRPCPDRFNGVQYDTSKSVYRECMADATW-ARRSNYSLCEAIILSKRNSQHYKVALVVNYL-GHCVSLLALMTAFTIFWCLRSIRCLRNAIHWNLMTTFILRNATWFLLQLIDLSTQERNEPWCCIIITIFNYFQVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWIFICIGWVIPAPIIIIWAMVKLHFEDEKCWFGKTPGKYIDYIYQGPIILVLLINFIFLFNIVTILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDEISQVIFLYVNSFLMSFQGFFVSVFYCFLNGEVRSAIRKRWHRWLDNH 352
BLAST of corticotropin-releasing factor receptor vs. Ensembl Sea Lamprey
Match: pth1r (parathyroid hormone 1 receptor [Source:ZFIN;Acc:ZDB-GENE-991123-8]) HSP 1 Score: 144.436 bits (363), Expect = 2.255e-38 Identity = 122/394 (30.96%), Postives = 189/394 (47.97%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSW---TANK--SNYNSC-------VNGRHEEI--NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRIL-----------------QIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLR-RLRTRHFAIIGWGFPMAL-----TSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF----TYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAW 1253
+C A +DG++CWP G CP ++++++ +A R+C ++G+W TAN+ +NY+ C V + +E L ++ GY++S+ L AL + F+ L CTRN+IH HLF +F+LR+AS V + S + LR+ ++V+ + + W+L+EGLYL+ LI+ T+ RL T FA+IGWGFP+ + TL N + DL L + PI+ + +N ++ + I+ L KLR N + S Q +YRK +K+TLVLMPL G +Y++F + V L Y F S QGF VA+IYCF N EVR ++ W
Sbjct: 47 HCTAEWDGLICWPWGLPGSMVREKCPSYI--YDFNAHGHAYRKCESNGTWKMSTANRLWANYSECTEFLNPHVQAKEKESIHRLSILYTIGYSVSLASLAIALCILTVFRRLHCTRNYIHMHLFVSFMLRAASIFVKDGVLYSDNELRLATPGPSPPAEAPHIFAGCRVVVTLFLYCLATSYFWVLVEGLYLYSLIFLTFSASGRLWT--FALIGWGFPVVFVFVWAAARATLAN--SQCWDLSAGWLKWIYQAPILAAVAVNFVLFVNIVRVLATKLRET----------------------NAARQESRQ------QYRKLLKSTLVLMPLFGVHYVLFAAMPYTDVIGLAWQIQMYYEMTFNSFQGFFVAIIYCFCNGEVRGEMKKLWSRW 406
BLAST of corticotropin-releasing factor receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000542.1 (pep scaffold:Pmarinus_7.0:GL476735:164228:192153:1 gene:ENSPMAG00000000476.1 transcript:ENSPMAT00000000542.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 122.094 bits (305), Expect = 1.999e-30 Identity = 97/365 (26.58%), Postives = 166/365 (45.48%), Query Frame = 3
Query: 192 EYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSW----TANK--SNYNSC----VNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVL-MISRLAHLAI----FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTS--TQGFMVALIYCFQNIEVRKLVR 1235
++C +DG +CW T AG+ A+ CP F F D + T+ C+TDG W +N+ SNY C + +NL + ++G+ +SI+ L +L +F +FK+L C R +H +LF ++IL S ++ + L + V + + H + + WML EG+YL LI + + ++GWGFP+ + + + W+ + +L+IIH VV + V+ + THR + Y KA++ATL+L+PLLG +++ V ++ Y+ +F + QGF+VA I+CF N EV+ ++
Sbjct: 39 KHCNRTWDGWLCWGDTMAGDVAVQHCPDYFPDF--DLQEKVTKICNTDGQWFRHPDSNRTWSNYTLCNAFTADKLKMAVNLFYLAVTGHGVSILVLLVSLTIFFYFKSLSCQRITLHKNLFMSYILNSIITIIQLTAVANNQELVASKPVWCKVLQFFHQYMMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLFWYYLLGWGFPIVPALMHAVARTIYYDDNCWISSATH----------------LLYIIHGPVVAALLVNLFFLLNIVRVL------VTKLKVTHRAETSM------YMKAVRATLILVPLLGIQFVLVPWKPERFVGEIYDYIMQIFPTHLIQGFLVATIFCFCNGEVQAALK 373
BLAST of corticotropin-releasing factor receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003797.1 (pep scaffold:Pmarinus_7.0:GL477934:1164:14009:-1 gene:ENSPMAG00000003461.1 transcript:ENSPMAT00000003797.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 97.8265 bits (242), Expect = 1.883e-23 Identity = 64/198 (32.32%), Postives = 95/198 (47.98%), Query Frame = 3
Query: 198 CEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSC----------VNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASF----LVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGW 746
C + D + CWP T G+ PCP F+G Y+ + R+C +G+W A SNY+ C H E+ L+ ++ G+ +S+ L A LF ++++C RN IH +L S FILR++ F L+ F + P ++V I H+ F WM EG YL I TY +LR F +GW
Sbjct: 44 CNSTLDEIETCWPSTPVGQVVSRPCPEFFNGVRYEIHRTVYRECLENGTW-ALISNYSECKPIVENKEVQTESFHYEVALIINYL-GHCISLAALVIAFLLFMGLRSIRCLRNIIHWNLISTFILRNSMFYTLQLIDFRTQEANEPW--CRVVSTIYNYFHVTNFFWMFGEGCYLHTAIVMTYSTDKLRKWVFLCLGW 237
BLAST of corticotropin-releasing factor receptor vs. Ensembl Nematostella
Match: EDO34537 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP31]) HSP 1 Score: 68.5514 bits (166), Expect = 7.059e-13 Identity = 71/280 (25.36%), Postives = 120/280 (42.86%), Query Frame = 3
Query: 390 EEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALT--SANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVR 1223
E+++L + G +S + L L +F ++L R+ IH +L A L A L L I +G+ + Q+V + F WML EG++L+ + + + +R H+ I GWGFP + SA N + + W+ D F + + + I+ L++ + + + +VK + H R +K LVLMPLLG +I + + F F Y+ A+ S QGF++ L++ N EVR
Sbjct: 41 EKLSLQIITYIGCGISSVALLITLVIFLSIESLSTERHRIHLNLVLALFL--AQILFLSGINATGNKIG-CQVVAAFLHYFYTVAFTWMLNEGVHLYLKVVKVFRIENVRLLHYYIFGWGFPAVIVGISAAIKPNSYGTESICWLSLSDDFV------WAFIGPVTFIIAINCLILIVVVKTIVNSASTVKNSDHAH----------------------IRAGVKGALVLMPLLGVSWISGLLAVNKDTVF-FQYVFAITNSFQGFLIFLLHVVFNTEVR 288
BLAST of corticotropin-releasing factor receptor vs. Ensembl Nematostella
Match: EDO39196 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAS3]) HSP 1 Score: 62.3882 bits (150), Expect = 1.028e-10 Identity = 69/278 (24.82%), Postives = 124/278 (44.60%), Query Frame = 3
Query: 405 VGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPS-GHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWG-----FPMALTSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEV 1220
+G+ I+G L+I+ + LFL +L+ R FIH +L +A + +LFI+ + P + V ++ ++++F WML+EG++++ L+ + R R + + +IGWG FP + + N T+ W+ + + I F+ ALVV L + V L + + N R +KA + L+P+LG ++ ++ K +F YL A+F S QGF++ + YC + EV
Sbjct: 62 LGLSIAGCVLTIL---THLFL----PSLRSERVFIHINLVTAILFAQ----ILFIVGATHREPQSLCLSVAVLLYFFYMSVFTWMLVEGIHIYCLVIRVFNSGRGRKKIYTVIGWGEFLSIFPSGMPA---FRNSSTTSSRCWLS--------------LESGAIWAFVAPALVVIAFNLVILFMVLRVTAVMLKDESQTSSNVCLS------------RALVKAFVTLLPILGLTWLFGFLAFNNK-TVMFEYLFAIFNSMQGFLIFVFYCLLSSEV 298
BLAST of corticotropin-releasing factor receptor vs. Ensembl Nematostella
Match: EDO48237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKF4]) HSP 1 Score: 63.929 bits (154), Expect = 1.370e-10 Identity = 73/278 (26.26%), Postives = 122/278 (43.88%), Query Frame = 3
Query: 405 VGVFISGYALSIICLCSALFLFCHFKALKCTR-NFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALT--SANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKR---FELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEV 1220
+G +I G A+S+ L A F + LK + N IH +L +A ++ FL T R++ I+L +F WML+EG+++++ + + R + +GWG P + SA + + H WM TD ++I F I ++V + S++R F LP ++ C Y L R YR M+A+ V++PLLG + I + ++ +F YL A T+ QG + L YC + +V
Sbjct: 2238 IGTYI-GIAVSVAILLIAFVSFVCLRGLKKSNANDIHKNLVAAIVIAEIIFLAGINRTNDTTACRLVAILL---HYFFSTVFTWMLVEGVHMYRRLSEKRNIDTGRMNFYYFLGWGCPAIVVGISAGLSTEGYGNNHFCWMA-----TD---------GTLIWTFTIPVMIVVAVS--------SMERFFFFTLPSHETFTC-----YFYLLMR--SLYRAGMRASAVVLPLLGVSLVFAILMVNKDME-MFHYLFAALTAFQGLFIFLFYCLFDKKV 2481
BLAST of corticotropin-releasing factor receptor vs. Ensembl Nematostella
Match: EDO44368 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW06]) HSP 1 Score: 58.5362 bits (140), Expect = 9.346e-10 Identity = 42/144 (29.17%), Postives = 71/144 (49.31%), Query Frame = 3
Query: 354 KSNYNSCVNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRH---FAIIGWGFPMALTSAN 776
K + ++ + G H + L + G LS++ LC AL F F+ LK +R F+H +L + IL A L LF + + L + QI+ + LA F WM +EG+ L+ ++ +G + + + F GWG P + +
Sbjct: 48 KGDMDAILKGDHR-LALSLITYIGIVLSVVTLCIALLTFITFRFLKSSRTFLHKNLSISLIL--AQLLFLFGVNKTEIKL-VCQIIAALLHYLWLASFAWMALEGVMLYLMLVKVFGTKTITNKKRAVFLTFGWGLPAVVVGVS 187
BLAST of corticotropin-releasing factor receptor vs. Ensembl Nematostella
Match: EDO50018 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RF24]) HSP 1 Score: 56.6102 bits (135), Expect = 7.768e-9 Identity = 51/205 (24.88%), Postives = 94/205 (45.85%), Query Frame = 3
Query: 630 AHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALT--SANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRG 1238
A +++F WML+EG++L+++I + + R + + IGWG PM + ++ + + +P+ W+ D+ I F A+VV L LG +V R ++++ +HR + + R + +++L+PLLG + IF + + Y+ A S QG M+ +C N EV L+ G
Sbjct: 120 AFMSVFSWMLVEGIHLYQMIIIAF-ITRAMMKFYYFIGWGLPMCIVVIASCISHKGYGTPNFCWLSLTDH--------------TIWAFTGPAIVVILVNAVVLG---AVLRLRTKLENNA--EVSHRACLSI----LFLRTGARVSIMLLPLLGLSW-IFGLFTAMEGTLVIQYIFAATNSLQGLMIFAFHCVGNSEVGCLLIG 299
BLAST of corticotropin-releasing factor receptor vs. Ensembl Medaka
Match: CRHR2 (corticotropin-releasing factor receptor 2 [Source:NCBI gene;Acc:101157488]) HSP 1 Score: 150.214 bits (378), Expect = 2.376e-39 Identity = 116/387 (29.97%), Postives = 184/387 (47.55%), Query Frame = 3
Query: 159 NRSLFYQDNNIEYCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVN--------GRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAI--FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM-----RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPK--VKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGY 1265
N SL + YC A D + CWP + G PCP +G +Y++ +A R+C +G+W A K NY++C H +I L+ ++ G+ +S+ L A LF ++++C RN IH +L + FILR+ + +L +I + H L+ + + + F WM +EG YL I TY +LR F IGW P + + ++ W + +DY P+I +L++N + + I+ L+ KLRA S ++T ++YRKA+KATLVL+PLLG Y++F + + +F Y N+ S QGF V++ YCF N EVR VR R W++ +
Sbjct: 92 NASLSLLSADGLYCNATVDEIGTCWPRSSTGRIVERPCPAYINGVKYNATRSAYRECMDNGTW-ALKINYSNCEPILEEKRKYPMHYKIALIINYL-GHCISVGALVVAFVLFLCLRSIRCLRNIIHWNLITTFILRNVMWFLLQLIDHNIHESNEPWCRLITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPCPIIVTWAIGKLYFENEKCWFGKEPGKYMDYIYQGPVILVLLINFVFLFNIVRILMTKLRA--------------------STTSET-----------IQYRKAVKATLVLLPLLGITYMLFFVNPGEDDISQIVFIYFNSFLQSFQGFFVSVFYCFLNGEVRSAVRKRWHRWQDNH 445
BLAST of corticotropin-releasing factor receptor vs. Ensembl Medaka
Match: pth1r (parathyroid hormone 1 receptor [Source:NCBI gene;Acc:101155466]) HSP 1 Score: 147.517 bits (371), Expect = 4.387e-38 Identity = 117/393 (29.77%), Postives = 187/393 (47.58%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSW---TANKS--NYNSCV------NGRHEEI---NLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLM-----------ISRLAHLAI--------------FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSA-NTLYNIFTSPH--DLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVK----FLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
+C A +DG++CWP G+ CP ++++ A R+C +G+W +ANK+ NYN C N HE+ L ++ GY++S+ L A+ + +F+ L CTRN+IH HLF +++LR+ S V ++ S PL ++ V + +++ +A ++W+L+EGLYL LI+ T+ R F +IGWG P S T+ F DL L + +PI+ +++N I+ L II L KLR ++ C+ +YRK +K+TLVLMPL G +YIIF + +V + + +F S QGF+VA+IYCF N EV+ ++
Sbjct: 60 FCSAEWDGIVCWPEGPPGKLVSTACPEYI--YDFNHKGLAYRRCDNNGTWEQASANKTWANYNECAKFLYHYNHSHEKEVFHRLYLIYTVGYSVSLGSLMVAVVILGYFRRLHCTRNYIHMHLFVSYMLRAISIFVKDVVLYSESPLENMERVTLDDLKSITIAPPVNKTQFIACKVVVTLFMYFLATNYYWILVEGLYLHSLIFMTFFSDRKYLWGFTLIGWGVPAVFVSIWATVRATFADTECWDLSAGNLKWIYQVPILMAVVVNFILFLNIIRVLATKLR-----------------ETNAGRCDTRQ-----------QYRKLLKSTLVLMPLFGVHYIIFNAMPYTEVSGIPWLIQMHYEMLFNSFQGFLVAIIYCFCNGEVQAEIK 422
BLAST of corticotropin-releasing factor receptor vs. Ensembl Medaka
Match: ENSORLT00000007395.2 (vasoactive intestinal polypeptide receptor 2-like [Source:NCBI gene;Acc:101155464]) HSP 1 Score: 138.272 bits (347), Expect = 1.557e-35 Identity = 108/378 (28.57%), Postives = 171/378 (45.24%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLV------GVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLV----LFIIT---PSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAI---IGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYNNPKLS 1283
C+ +D + CW T GE +PCP + N N +R C+ G W+ N +S + LV ++ G++LS+I L + + C F+ L CTRN+IH +LF +FILR+ + LV LF T + L + L+ + +A F W+L+EGLYL L+ + RHF I IGWG P SA + I+ L ++++ + + II LV KLR D G +++ +YR+ K+TL+L+PL G +Y++F++ + + + S QGF+VA++YCF N EV+ +R + WR N +LS
Sbjct: 46 CKGTWDSIACWEHTGLGETVTIPCPRALKTI-FGRNGNISRNCTASG-WSEVFPNISSVCESDTSQNKLVFYVVVQALYTLGHSLSLIALITGSAILCLFRKLHCTRNYIHLNLFVSFILRAVAVLVKDDILFNKTLQCSNQSSLLGCKASLVFFQYFIMANFFWLLVEGLYLHTLLVVIFS----ENRHFIIYMFIGWGIPTVFVSAWVITRIYLEDTGLRYFKVNFI--------------LFISIIRILVQKLRC-----------------PDVGGNDQS------------QYRRLAKSTLLLIPLFGIHYVVFVSFSESITEDYKIFFDLALGSFQGFVVAILYCFLNSEVQGELRRK---WRSMCLNCRLS 371
BLAST of corticotropin-releasing factor receptor vs. Ensembl Medaka
Match: pth3r (parathyroid hormone/parathyroid hormone-related peptide receptor [Source:NCBI gene;Acc:101173747]) HSP 1 Score: 133.65 bits (335), Expect = 4.230e-33 Identity = 111/380 (29.21%), Postives = 169/380 (44.47%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSW---TANK---SNYNSC---VNGRHEEIN------LVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFL----VLFIITPSGHPLRILQIVLMISRLAHLAIF--------HWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLW---MRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLF----TYLNAMFTSTQGFMVALIYCFQNIEVRKLVR 1235
C +DG++CWP +RAG+ +PCP ++++ A RQC G+W T+N +NY C + H + L ++ GY++S+ L A+ + C+FK L CTRN+IH HLF++FI R+ S VL+ IT + A + F +W+L EGLYL LI+ + I+GWG P S + W L + +PI+ + +N ++ + II L KL + P Q +YRK +++TLVLMPL G +YI+F+ + +V L + F S+QGF VA IYCF N EV+ V+
Sbjct: 61 CVPEWDGIICWPQSRAGQLVSVPCPEYI--YDFNHRGRAYRQCDVTGNWELVTSNNHTWANYTECTRYLTSNHRSLQEKVFKRLHLMYTVGYSISLSSLLVAVSILCYFKRLHCTRNYIHIHLFTSFICRAVSIFVKDSVLYSITDDSKAEFPAERQYTAGCKAAVTFFLYFLATNHYWILAEGLYLHSLIFMALLSDKNYLWVLTIMGWGIPAVFVSVWVSARASLADTQCWDISAGNLKWIYQVPILAGIFVNFLLFINIIRVLASKLWETNTGKLN--------PRQ--------------------QYRKLLRSTLVLMPLFGVHYIVFMAIPYTEVNGLLWQVQMHYEMFFNSSQGFFVAFIYCFCNGEVQAEVK 410
BLAST of corticotropin-releasing factor receptor vs. Ensembl Medaka
Match: calcr (calcitonin receptor [Source:NCBI gene;Acc:101174680]) HSP 1 Score: 128.642 bits (322), Expect = 6.284e-32 Identity = 110/388 (28.35%), Postives = 181/388 (46.65%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSW----TANK--SNYNSCVNGRHEEIN----LVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQ--IVLMISRLAHLAI----FHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMR---QLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKF---LFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYNNPKLSHVS 1292
+C +DG +CW T AG A CP+ FD F D + AT+ C DG W N+ SNY C ++ L + I G+ALSI L +L +F +F++L C R +H +LF +++L SA +++++T +P + + + + H+ + + WML EG+YL LI + ++GWGFP+ S + + + WM L Y PI+ L++N +L II LV KLR THR + Y KA++ATL+L+PLLG ++IF + P+ + ++ Y+ + QG +VA I+CF N EV+ ++ + + ++ + + H S
Sbjct: 44 FCSRNWDGWLCWEDTPAGTFAAQNCPNYFDDF--DPTEKATKYCGEDGQWFRHPDTNRTWSNYTLCNENTKAKLKSAYILFYMAIVGHALSIASLLISLAIFFYFRSLSCQRITLHKNLFFSYVLNSA-LTIIYLVTVVNNPEVVARNPVGCKVLHFFHMYMLGCNYFWMLCEGIYLHTLIVVAVFAEEQHLHWYYLLGWGFPLVPVSIHAVARKKYFDDNCWMSVETHLLYAVHGPIVAALLVNLFFLLNIIRVLVTKLR-------------------------DTHRAESNM------YMKAVRATLILVPLLGIQFVIFP--WRPENRLAGEVYEYVMHILMHYQGLLVATIFCFFNGEVQGALKRQWMQYKTQWGQRRKDHCS 395
BLAST of corticotropin-releasing factor receptor vs. Planmine SMEST
Match: SMESG000049048.1 (SMESG000049048.1) HSP 1 Score: 857.44 bits (2214), Expect = 0.000e+0 Identity = 425/426 (99.77%), Postives = 426/426 (100.00%), Query Frame = 3
Query: 195 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYNNPKLSHVSRILLLILCCIYKPNPSIIQNGQRIRSIYHCQGNNQTYRKSTVAEKPNTTDVEGKPGFVLA 1472
YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDIPIITILIMNSIIMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYNNPKLSHVSRILLLILCCIYKPNPSIIQNGQRIRSIYHCQGNNQTYRKSTVAEKPNTTDVEGKPGF+LA
Sbjct: 25 YCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDIPIITILIMNSIIMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYNNPKLSHVSRILLLILCCIYKPNPSIIQNGQRIRSIYHCQGNNQTYRKSTVAEKPNTTDVEGKPGFILA 450
BLAST of corticotropin-releasing factor receptor vs. Planmine SMEST
Match: SMESG000051050.1 (SMESG000051050.1) HSP 1 Score: 175.252 bits (443), Expect = 5.741e-49 Identity = 120/360 (33.33%), Postives = 190/360 (52.78%), Query Frame = 3
Query: 198 CEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHE-EINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFI--ITPSGHPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWMRQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFITHYHP-KVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGY 1265
C +DG W T + A CP Y+ +N TR C +G W A KSNY+ C+ ++ E +++ + GY +S I L AL LF +F++L+C RN IHC+L ++I+R ++ ++ + IT + P+ I+ I +I + + + WM +EG YL +I WTYG+ +L+ H+++IGWGFP L+S + T + +F + + I + I V + A + K +K+ ++P R S +LS F EYRKA+KA VL+PLLG + +F+ K + + L A+ TSTQGF VALIYCF N EVR +++ + ++R GY
Sbjct: 30 CPPSYDGFRNWTYTISNTVATQKCPGKSLKPYYNDKENITRMCLANGVW-AKKSNYDRCIMMPNKIEYHVIATWFVGYTISTIALWIALILFRYFRSLRCIRNDIHCNLIVSYIVRVFTWYLIIVPQITTTDWPITIVNITTIIILFSQASNYLWMFVEGFYLLIIIVWTYGIDKLKMWHYSLIGWGFPTLLSSILAISIALTENFN-----ESWFNSSKAKPLKLYIIHIPILISIIANVFVLAVIIYTVFKKLKQTKIP---------VTRRSSKLSLFSTEYRKAIKAAAVLIPLLGIAHCLFMFESKSLKYQDAYKILTAILTSTQGFFVALIYCFLNREVRFVLKAKYRSFR-GY 373
BLAST of corticotropin-releasing factor receptor vs. Planmine SMEST
Match: SMESG000023013.1 (SMESG000023013.1) HSP 1 Score: 143.28 bits (360), Expect = 1.162e-37 Identity = 110/368 (29.89%), Postives = 179/368 (48.64%), Query Frame = 3
Query: 183 NNIEYCEAIFDGV-MCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSW----TANK--SNYNSCVNGRHEEINLVGVFISGYALSIICLCSALFLFCHFKALKCTRNFIHCHLFSAFILRSASFLVLFIITPSGHPLRI----LQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYN-IFTSPHDLWMR--QLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYII-FITHYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGR 1241
N YC A D + CW T+AGE A PCP GF + N A+++C +G+W N SNY+ C+ + ++LV VF +GY+LS++CL +LF+F FK L+C R +H +LF ++ + ++ +++ +G ++ QI+ +I+ + + WM EG+YL ++ T+ + + GWG P+ LTS + + P W ++ IP + L N +I+LFI+ LV KL S+ +R ++ K KA +L+PLLG II FI + +V+ + Y A+ +S QG +V+ I CF N EVR ++R R
Sbjct: 18 NGTSYCNATKDKLGTCWNYTKAGEIAFAPCPK-LPGFNW--NAEASKKCEINGTWYFSIEENNYWSNYSKCLQNK-PNVSLVYVFFAGYSLSVLCLSISLFIFFVFKQLRCDRVTLHKNLFMCHLINAIIWINFYVVISNGDVMQRNPIHCQILFVIATYFSVGTYFWMFSEGIYLAVILILTFHKGPILLTICIVTGWGLPLILTSIYVISRYLMEKPEKCWTEPSKMYLILAIPNVVALGANLLILLFILKTLVTKL-------------------------------SHPTNREETQWSKTAKAVFILIPLLGLQNIIFFIYPDNQEVRLIQDYSTAVLSSFQGVLVSFILCFFNHEVRTIIRRR 350
BLAST of corticotropin-releasing factor receptor vs. Planmine SMEST
Match: SMESG000064388.1 (SMESG000064388.1) HSP 1 Score: 141.354 bits (355), Expect = 1.051e-36 Identity = 96/274 (35.04%), Postives = 151/274 (55.11%), Query Frame = 3
Query: 480 KALKCTRNFIHCHLFSAFILRSASFLVLFIITPSG-HPLRILQIVLMISRLAHLAIFHWMLIEGLYLFKLIYWTYGLRRLRTRHFAIIGWGFPMALTSANTLYNIFTSPHDLWM---RQLDYFTDXXXXXXXXXXXXXMLFIIHALVVKLRARRPLGIQKSVKRFELPHQDSSGCNKTHRMSYQLSRFPVEYRKAMKATLVLMPLLGFYYIIFI-THYHPKVKFLFTYLNAMFTSTQGFMVALIYCFQNIEVRKLVRGRLIAWREGYNNPKLSH 1286
K+L+C RN IHC+L +FI+R ++ ++ + S +P + ++ ++ + LA F WM +EGLYL +I WTY + +++ HF IIGW P LT+A + + + D W+ ++ +PII IL++N+I +LFI+ L+ KL+A + + R + EY+KA+K+T+VLMPLLGF +IIFI + K+ +F NA+ +S+QGF V+LIYCF N EVR +R L NN + H
Sbjct: 104 KSLRCLRNIIHCNLILSFIIRVILWISIYASSFSKPYPQMVSNVLFALNISSQLANFFWMFVEGLYLLIVIVWTYRIEKVKIWHFTIIGWAVPALLTTAWVIVMVTENIED-WVGYRGKMKLIVHLPIILILVVNAIALLFIVITLIEKLKA-------------------TKNQQQNSRRNNAFGPLTNEYKKALKSTVVLMPLLGFSHIIFICSPPESKLTVVFNITNAILSSSQGFWVSLIYCFFNGEVRMTLRNHLFKCARFQNNIRTRH 357
BLAST of corticotropin-releasing factor receptor vs. Planmine SMEST
Match: SMESG000064393.1 (SMESG000064393.1) HSP 1 Score: 114.775 bits (286), Expect = 7.125e-30 Identity = 51/125 (40.80%), Postives = 77/125 (61.60%), Query Frame = 3
Query: 108 NFLGTINRRQNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPTRAGEQAILPCPHTFDGFEYDSNDNATRQCSTDGSWTANKSNYNSCVNGRHEEINLVGVFISGYALSIICLCSALFLFCHFK 482
N+ +++ CRK HFN + F+++ NI +C A++D V+CW PT G AI PCP+ F GF Y++ +NA + C + +W A ++NY SC L ++I GY LS+I LCSA +F +FK
Sbjct: 3 NYTEFVSKFIKCRKTHFNTTYFFKNQNISFCPAVYDYVLCWKPTERGRIAIEPCPNEFSGFNYNNYENAEKYCLPNATW-AQRANYESCYKLSQHNSVLFWLYIIGYGLSLISLCSAFVIFSYFK 126 The following BLAST results are available for this feature:
BLAST of corticotropin-releasing factor receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of corticotropin-releasing factor receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of corticotropin-releasing factor receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30034211 ID=SMED30034211|Name=corticotropin-releasing factor receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=1584bpback to top protein sequence of SMED30034211-orf-1 >SMED30034211-orf-1 ID=SMED30034211-orf-1|Name=SMED30034211-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=463bp MLNTSNFNFLGTINRRQNCRKEHFNRSLFYQDNNIEYCEAIFDGVMCWPPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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