Cystinosin

Overview
NameCystinosin
Smed IDSMED30034181
Length (bp)1657
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cystinosin (SMED30034181) t-SNE clustered cells

Violin plots show distribution of expression levels for Cystinosin (SMED30034181) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cystinosin (SMED30034181) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cystinosin (SMED30034181) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30034181

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30034181SMESG000016910.1 SmedASXL_019482SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30034181SMESG000016910.1 dd_Smed_v4_4540_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30034181SMESG000016910.1 dd_Smed_v4_4540_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30034181SMESG000016910.1 dd_Smed_v4_4540_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30034181SMESG000016910.1 dd_Smed_v4_4540_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30034181SMESG000016910.1 dd_Smed_v4_4540_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30034181SMESG000016910.1 dd_Smed_v6_4540_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30034181SMESG000016910.1 OX_Smed_1.0.14304ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
reproductive organSMED30034181SMESG000016910.1 Contig48962newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30034181SMESG000016910.1 Contig48962uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
nervous systemSMED30034181SMESG000016910.1 dd_Smed_v4_4540_0_1dd_Smed_v4PMID:30962434
Cote et al., 2019		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Cystinosin vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518])

HSP 1 Score: 167.933 bits (424), Expect = 4.988e-46
Identity = 92/214 (42.99%), Postives = 141/214 (65.89%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ+++N++RKSVIGL+FDF+  N+TGF+AYS+FN  L +   ++++F   Y    NPV  ND+FFS++A+ + LI+ +QC +Y RG Q++S     F+ L  +++ ++ ++          +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAA----VGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518])

HSP 1 Score: 166.777 bits (421), Expect = 5.971e-46
Identity = 92/214 (42.99%), Postives = 141/214 (65.89%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ+++N++RKSVIGL+FDF+  N+TGF+AYS+FN  L +   ++++F   Y    NPV  ND+FFS++A+ + LI+ +QC +Y RG Q++S     F+ L  +++ ++ ++          +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAA----VGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518])

HSP 1 Score: 166.777 bits (421), Expect = 5.971e-46
Identity = 92/214 (42.99%), Postives = 141/214 (65.89%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ+++N++RKSVIGL+FDF+  N+TGF+AYS+FN  L +   ++++F   Y    NPV  ND+FFS++A+ + LI+ +QC +Y RG Q++S     F+ L  +++ ++ ++          +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAA----VGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518])

HSP 1 Score: 134.035 bits (336), Expect = 3.382e-35
Identity = 79/192 (41.15%), Postives = 122/192 (63.54%), Query Frame = 1 
Query:  265 LNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            +N++RKSVIGL+FDF+  N+TGF+AYS+FN  L +   ++++F   Y    NPV  ND+FFS++A+ + LI+ +QC +Y RG Q++S     F+ L  +++ ++ ++          +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:    1 MNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIV----AAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 188
[Close]
BLAST of Cystinosin vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518])

HSP 1 Score: 132.494 bits (332), Expect = 5.821e-35
Identity = 79/192 (41.15%), Postives = 122/192 (63.54%), Query Frame = 1 
Query:  265 LNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            +N++RKSVIGL+FDF+  N+TGF+AYS+FN  L +   ++++F   Y    NPV  ND+FFS++A+ + LI+ +QC +Y RG Q++S     F+ L  +++ ++ ++          +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:    1 MNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIV----AAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 188
[Close]
BLAST of Cystinosin vs. Ensembl Celegans
Match: ctns-1 (Cystinosin homolog [Source:UniProtKB/Swiss-Prot;Acc:Q09500])

HSP 1 Score: 149.828 bits (377), Expect = 5.244e-40
Identity = 85/208 (40.87%), Postives = 121/208 (58.17%), Query Frame = 1 
Query:  175 MTLHKSLWIA---DLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLA 789
            +T+ +S ++A    + GW YF AW+ISFYPQ+ LN+KRKSV+GLNFDFL  N+ GF AY+IFN  +Y+N +++ E+         PV LND+ F+++A     I  +QC  Y R NQ +S  C   +I + S          T    +  L+ +  LSY+K+  T  KY PQ   N+ R+ST GWSI N+  D TGG    LQ+ + A
Sbjct:  117 ITVIRSHFLAILIQIVGWTYFFAWSISFYPQMYLNFKRKSVVGLNFDFLSLNLVGFCAYAIFNLLMYYNSHVKNEYNIVNPRSPPPVLLNDVVFAVHAFLACFITILQCLFYERDNQSVSSKCIALMIVLISF--GFCSAAATVLRKIQLLSFVTSLSYIKMAVTCCKYFPQAYFNYTRKSTVGWSIGNIMLDFTGGTLDILQMILQA 322
[Close]
BLAST of Cystinosin vs. Ensembl Celegans
Match: ctns-1 (Cystinosin homolog [Source:UniProtKB/Swiss-Prot;Acc:Q09500])

HSP 1 Score: 150.214 bits (378), Expect = 5.275e-40
Identity = 85/208 (40.87%), Postives = 121/208 (58.17%), Query Frame = 1 
Query:  175 MTLHKSLWIA---DLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLA 789
            +T+ +S ++A    + GW YF AW+ISFYPQ+ LN+KRKSV+GLNFDFL  N+ GF AY+IFN  +Y+N +++ E+         PV LND+ F+++A     I  +QC  Y R NQ +S  C   +I + S          T    +  L+ +  LSY+K+  T  KY PQ   N+ R+ST GWSI N+  D TGG    LQ+ + A
Sbjct:  117 ITVIRSHFLAILIQIVGWTYFFAWSISFYPQMYLNFKRKSVVGLNFDFLSLNLVGFCAYAIFNLLMYYNSHVKNEYNIVNPRSPPPVLLNDVVFAVHAFLACFITILQCLFYERDNQSVSSKCIALMIVLISF--GFCSAAATVLRKIQLLSFVTSLSYIKMAVTCCKYFPQAYFNYTRKSTVGWSIGNIMLDFTGGTLDILQMILQA 322
[Close]
BLAST of Cystinosin vs. Ensembl Celegans
Match: try-1 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q23528])

HSP 1 Score: 71.633 bits (174), Expect = 1.548e-13
Identity = 71/285 (24.91%), Postives = 108/285 (37.89%), Query Frame = 1 
Query:  799 EKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHF-CAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYF---PDLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIK-------PLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWIN 1620
            + ++IGG       WP  V L                 S+ GH  C G+LI  ++V+TAA CF                   R   + ++    R                   +  + +HP Y +        YD A++++  P++      P  LP      + L C   GWG +      S+   RE  V LL   +C+           P  +C  G   G  + D C  D+GGPL+C+    DG W+L G++S  +   C  P   G+Y NV   + WIN
Sbjct:   55 DHRLIGGSESSPHSWPWTVQL----------------LSRLGHHRCGGSLIDPNFVLTAAHCFAKDR---------------RPTSYSVRVGGHRSGSGSP-----------HRVTAVSIHPWYNIGF---PSSYDFAIMRIHPPVNTSTTARPICLPSLPAVENRL-CVVTGWGSTIEGSSLSAPTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLC-AGYSYG--KIDSCQGDSGGPLMCAR---DGHWELTGVVSWGI--GCARPGMPGVYGNVHSASTWIN 285
[Close]
BLAST of Cystinosin vs. Ensembl Fly
Match: CG17119 (gene:FBgn0039045 transcript:FBtr0084357)

HSP 1 Score: 180.644 bits (457), Expect = 4.200e-51
Identity = 105/225 (46.67%), Postives = 148/225 (65.78%), Query Frame = 1 
Query:  175 MTLHKS---LWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIA--LICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEKKI-IGGKPMK 831
            +T+ KS   ++ + +FGW+YF+AW++SFYPQI  NY+RKSV GLNFDFL  NI GF  YS+FN  LYF ++LQ E+   Y    NPV LND+ FS++A+F   I  +QCF Y R  Q++S   FIA  ++ I++++  ++   L   S + WL  L   SY+KL  T+IKY+PQ +MN+ R+STSGWSI N+  D TGG  S LQ+ + A+ Y+  + I G P K
Sbjct:  120 VTVAKSRALIYTSIIFGWVYFVAWSVSFYPQIWSNYRRKSVEGLNFDFLALNIVGFTLYSMFNCGLYFIEDLQNEYEVRYPLGVNPVMLNDVVFSLHAMFATCITILQCFFYQRAQQRVS---FIAYGILAIFAVV-VVVSAGLAGGSVIHWLDFLYYCSYVKLTITIIKYVPQALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNAHNYDDWVSIFGDPTK 340
[Close]
BLAST of Cystinosin vs. Ensembl Fly
Match: CG17119 (gene:FBgn0039045 transcript:FBtr0344299)

HSP 1 Score: 180.644 bits (457), Expect = 4.200e-51
Identity = 105/225 (46.67%), Postives = 148/225 (65.78%), Query Frame = 1 
Query:  175 MTLHKS---LWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIA--LICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEKKI-IGGKPMK 831
            +T+ KS   ++ + +FGW+YF+AW++SFYPQI  NY+RKSV GLNFDFL  NI GF  YS+FN  LYF ++LQ E+   Y    NPV LND+ FS++A+F   I  +QCF Y R  Q++S   FIA  ++ I++++  ++   L   S + WL  L   SY+KL  T+IKY+PQ +MN+ R+STSGWSI N+  D TGG  S LQ+ + A+ Y+  + I G P K
Sbjct:  120 VTVAKSRALIYTSIIFGWVYFVAWSVSFYPQIWSNYRRKSVEGLNFDFLALNIVGFTLYSMFNCGLYFIEDLQNEYEVRYPLGVNPVMLNDVVFSLHAMFATCITILQCFFYQRAQQRVS---FIAYGILAIFAVV-VVVSAGLAGGSVIHWLDFLYYCSYVKLTITIIKYVPQALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNAHNYDDWVSIFGDPTK 340
[Close]
BLAST of Cystinosin vs. Ensembl Fly
Match: CG6048 (gene:FBgn0029827 transcript:FBtr0070863)

HSP 1 Score: 79.7221 bits (195), Expect = 9.589e-16
Identity = 75/252 (29.76%), Postives = 113/252 (44.84%), Query Frame = 1 
Query:  889 KSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASD---TNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC------APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWI 1617
            K++N  Y   TGH C G+LI   WV+TAA CF    V+++I +G  T+    +   +M  L  R N ++      E        E I+   ++ LS        DIAL+ L   +    P + PIA +       + C+  GWG  N  D   S      DV ++  ++C         I+P  IC  G +E  ++ D C  D+GGPL+C         +L G++S  ++  C  P   G+YT V  Y  WI
Sbjct:   65 KALNDGYFFGTGHLCGGSLIRPGWVLTAAHCF----VDQIIYDG--TFVPKEEFIVVMGNL-DRYNRTNTLTFTIE--------ERIMQLDKFDLS----TYDKDIALLMLNGTVPTGHPTIRPIALNRFAIPEGVVCQVTGWG--NTEDGYVSDILMTVDVPMISEEHCINDSDLGHLIQPGMIC-AGYLEVGEK-DACAGDSGGPLVCQS-------ELAGVVSWGIQ--CALPRLPGVYTEVSYYYDWI 284
[Close]
BLAST of Cystinosin vs. Ensembl Fly
Match: Corin (gene:FBgn0033192 transcript:FBtr0088909)

HSP 1 Score: 78.1814 bits (191), Expect = 1.136e-14
Identity = 80/309 (25.89%), Postives = 127/309 (41.10%), Query Frame = 1 
Query:  742 DLTGGIFSTLQIFMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI---DDYFPDLLPIASDTNSSLH----CKTAGWGVSNVNDYESSGEF--REFDVNLLPAKYCAPFIKPLEICG----VGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            DLT   +   ++    +   ++IIGG       WP + ++           +  P   +   +CAG LIS  WV+TA+ C  +  V  L +             W ++  V R N   Y         +   ++ ++ HP+Y ++I  +    DIAL +L   +   +   P  LP  S  N  LH    C   GWG     D +S+ E+   E  V ++    C  ++  L +       G  +G +  D C  D+GGPL+C   G    W + GI+S  +   C  P   G+Y NV+ Y  WI   I
Sbjct: 1082 DLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI-----------LGGP---EKIFYCAGVLISDQWVLTASHCVGNYSVIDLED-------------WTIQLGVTRRNSFTY-------SGQKVKVKAVIPHPQYNMAIAHDN---DIALFQLATRVAFHEHLLPVCLPPPSVRN--LHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGK--DACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIM--CAHPRLPGVYANVVQYVPWIQEQI 1347
[Close]
BLAST of Cystinosin vs. Ensembl Fly
Match: Corin (gene:FBgn0033192 transcript:FBtr0336996)

HSP 1 Score: 78.1814 bits (191), Expect = 1.136e-14
Identity = 80/309 (25.89%), Postives = 127/309 (41.10%), Query Frame = 1 
Query:  742 DLTGGIFSTLQIFMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI---DDYFPDLLPIASDTNSSLH----CKTAGWGVSNVNDYESSGEF--REFDVNLLPAKYCAPFIKPLEICG----VGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            DLT   +   ++    +   ++IIGG       WP + ++           +  P   +   +CAG LIS  WV+TA+ C  +  V  L +             W ++  V R N   Y         +   ++ ++ HP+Y ++I  +    DIAL +L   +   +   P  LP  S  N  LH    C   GWG     D +S+ E+   E  V ++    C  ++  L +       G  +G +  D C  D+GGPL+C   G    W + GI+S  +   C  P   G+Y NV+ Y  WI   I
Sbjct: 1082 DLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI-----------LGGP---EKIFYCAGVLISDQWVLTASHCVGNYSVIDLED-------------WTIQLGVTRRNSFTY-------SGQKVKVKAVIPHPQYNMAIAHDN---DIALFQLATRVAFHEHLLPVCLPPPSVRN--LHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGK--DACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIM--CAHPRLPGVYANVVQYVPWIQEQI 1347
[Close]
BLAST of Cystinosin vs. Ensembl Zebrafish
Match: ctns (cystinosin, lysosomal cystine transporter [Source:ZFIN;Acc:ZDB-GENE-050522-352])

HSP 1 Score: 176.022 bits (445), Expect = 2.498e-49
Identity = 101/215 (46.98%), Postives = 139/215 (64.65%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICI---YSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW++SFYPQ   N+KR+SV+GLNFDFL  N+TGFIAYS+FN  L++   +Q+EF K       PV  ND+FFS++AL + L+   QC IY RG QK+S+   I L+ I   ++ +S  +         +SWL  L   SY+KL  T++KY+PQ  MN+ R+ST GWSI NV  D TGG FS +Q+F+ AY  +K + I G P K
Sbjct:  131 INQIIGWIYFVAWSVSFYPQAYENWKRRSVVGLNFDFLALNLTGFIAYSVFNVGLFWVTYIQEEFLKKDPNGVIPVDANDVFFSLHALLLTLVYICQCAIYERGGQKVSKVA-IGLLAIGWTFAFVSLFVAVA----KKISWLDYLYYFSYIKLGVTLVKYIPQAHMNYRRKSTEGWSIGNVLLDFTGGSFSLIQMFLEAYNNDKWRFIFGDPTK 340
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BLAST of Cystinosin vs. Ensembl Zebrafish
Match: CR352265.1 (pep chromosome:GRCz11:24:21813127:21819010:-1 gene:ENSDARG00000062758.6 transcript:ENSDART00000091096.6 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CR352265.1)

HSP 1 Score: 97.8265 bits (242), Expect = 3.686e-22
Identity = 86/284 (30.28%), Postives = 125/284 (44.01%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI---DDYFPDLLPIASDT-NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF----IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            KI+GG   ++  WP  VSL+ +               + GH C  +L++S W+V+AA CFQD +  K        Y+  R  R  M   V  MN          + +  R I  IVLH +Y          YDIAL++L  P+   +   P  +P  S    S   C   GWGV    + E +   +E  VN++    C       + P  +C  GNI+G    D C  D+GGPL+C E G    W L GI+S      C   ++ G+YT V+ +  WI+   +
Sbjct:   54 KIVGGTDAQAGSWPWQVSLQME---------------RYGHVCGASLVASRWLVSAAHCFQDSDAIK--------YSDARSWRAYMGMRV--MNSV-------SNAAATRQIRRIVLHSQYDQFT----SDYDIALLELSAPVFFNELVQPVCVPAPSHVFTSGTSCFVTGWGVL-TEEGELATLLQEATVNIINHNTCNKMYDDAVTPRMLC-AGNIQGG--VDACQGDSGGPLVCLERGR--RWFLAGIVS--WGEGCARQNRPGVYTRVIKFTDWIHQQTK 293
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BLAST of Cystinosin vs. Ensembl Zebrafish
Match: tmprss13b (transmembrane serine protease 13b [Source:ZFIN;Acc:ZDB-GENE-090309-2])

HSP 1 Score: 87.4261 bits (215), Expect = 6.677e-18
Identity = 81/281 (28.83%), Postives = 120/281 (42.70%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCF-QDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASDT-NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC-APFIKPLEICGVGNIEGNQRS--DFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            +IIGG      +WP   SL  Q                  H C G+L++ D+++TAA CF ++   ++L +  K     V +L+            S Y+V            + I+LH +Y  +       YDIAL+KL  P  D  P  LP+   T   +  C T G+GV        S    E  V+L+ +  C +P +   EI       G+ R   D C  D+GGPL C     DG W L G+ S      CG  ++ G+Y++V  Y  WI S ++
Sbjct:  236 RIIGGSVAAEGHWPWQASLHFQGK----------------HSCGGSLVAPDFIITAAHCFPKETSGSQLPSNWKVYIGFVSQLKL----------PSPYYV------------KEIILHEKYNPTTK----NYDIALLKLNKPASDVEPICLPVIGQTFPPAKQCWTTGFGVIRQGSNSVSTSLMEVTVSLIDSSVCNSPNVYNGEITENMQCAGDLRGGKDSCQGDSGGPLACKS--NDGQWFLTGVTS--WGEGCGQVNRPGVYSDVAKYLMWIYSKMQ 470
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BLAST of Cystinosin vs. Ensembl Zebrafish
Match: tmprss13b (transmembrane serine protease 13b [Source:ZFIN;Acc:ZDB-GENE-090309-2])

HSP 1 Score: 87.4261 bits (215), Expect = 7.883e-18
Identity = 81/281 (28.83%), Postives = 120/281 (42.70%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCF-QDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASDT-NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC-APFIKPLEICGVGNIEGNQRS--DFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            +IIGG      +WP   SL  Q                  H C G+L++ D+++TAA CF ++   ++L +  K     V +L+            S Y+V            + I+LH +Y  +       YDIAL+KL  P  D  P  LP+   T   +  C T G+GV        S    E  V+L+ +  C +P +   EI       G+ R   D C  D+GGPL C     DG W L G+ S      CG  ++ G+Y++V  Y  WI S ++
Sbjct:  237 RIIGGSVAAEGHWPWQASLHFQGK----------------HSCGGSLVAPDFIITAAHCFPKETSGSQLPSNWKVYIGFVSQLKL----------PSPYYV------------KEIILHEKYNPTTK----NYDIALLKLNKPASDVEPICLPVIGQTFPPAKQCWTTGFGVIRQGSNSVSTSLMEVTVSLIDSSVCNSPNVYNGEITENMQCAGDLRGGKDSCQGDSGGPLACKS--NDGQWFLTGVTS--WGEGCGQVNRPGVYSDVAKYLMWIYSKMQ 471
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BLAST of Cystinosin vs. Ensembl Zebrafish
Match: AL954146.1 (trypsin I-P1-like [Source:NCBI gene;Acc:560023])

HSP 1 Score: 82.0333 bits (201), Expect = 3.233e-17
Identity = 75/264 (28.41%), Postives = 114/264 (43.18%), Query Frame = 1 
Query:  865 QQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNP--IDDYF-PDLLPIA--SDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF----IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            Q+ +PY++K   +       HFC GTLI   WV+TAA C++   V +++                         LS++ + ++E   +  ++  +  H  Y      N    DI +IKL  P  I+ Y  P LLP A   +      C  +GWGV+ + ++  S   R  DV +  +  C  +    +    IC      G    D C  D+GGPLIC       D  L GI+S  +   C  P   G+YT V  YN+WI+ +I
Sbjct:    3 QEVVPYSIK-YQVSLQVDRKHFCGGTLIQPQWVLTAAHCWRPASVIQVV-------------------------LSEHNLAVEEGFEQVCTVAKVFSHVAYNPKTFNN----DIMIIKLTAPAQINAYVQPALLPTADTPELAGGSSCTVSGWGVTRLYNFYLSPILRAVDVEIFSS--CQLYYYYRVNDNMICAGSRFGGK---DSCQGDSGGPLIC-------DGYLEGIVSWGI--GCALPYYPGVYTKVRNYNRWIDWII 222
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BLAST of Cystinosin vs. Ensembl Xenopus
Match: klhl24 (kelch like family member 24 [Source:Xenbase;Acc:XB-GENE-1000313])

HSP 1 Score: 171.014 bits (432), Expect = 1.321e-46
Identity = 94/212 (44.34%), Postives = 139/212 (65.57%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            +  + GW+YF+AW++SFYPQ+  N+KRKSV+GL+FDFL  N+TG IAY +FN  L++   ++++F + Y     PV+ ND+FFS++A+ +  I  IQC IY RG+Q +S+G    L+  +  + AL V  +     ++WL  L   SY+KL  T+IKY PQ  MN+ R+ST GWSI NV  D TGG FS +Q+F+ +Y  ++  +I G P K
Sbjct:  227 LQQIIGWIYFMAWSVSFYPQVFENWKRKSVVGLSFDFLALNLTGHIAYGVFNLGLFWIPYVKEQFLELYPNGVFPVEANDVFFSLHAVLLTAITIIQCCIYERGSQTVSKGAIGFLVIAW--LFALTVLFVAVAGKITWLLFLFCFSYIKLAITLIKYFPQAYMNFRRKSTEGWSIGNVLLDFTGGSFSIVQMFIQSYNNDEWNLIFGDPTK 436
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BLAST of Cystinosin vs. Ensembl Xenopus
Match: ENSXETT00000016723.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:9:2449088:2456215:1 gene:ENSXETG00000009233.1 transcript:ENSXETT00000016723.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.5817 bits (218), Expect = 6.044e-19
Identity = 83/307 (27.04%), Postives = 135/307 (43.97%), Query Frame = 1 
Query:  724 IINVFFDLTGGIFSTLQIFMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID--DYF-PDLLPIASDT-NSSLHCKTAGWGVSNVN-DYESSGEFREFDVNLLPAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            ++ +  +  G +  +L       +    ++GG+  +   WP  V++R Q                +G FC G+LI+S WVV+AA C  D+ V             V ++   +  ++++     +         + R ++N ++HP Y  +    + G DI L++LG  ++   Y  P  LP +  T  + L C   GWG    N + ES       D N   A +  P+IK   IC  GN+ G + S  C  D+GGPL+C+E      W L GI+S  L   C  P+   +Y  + G+  WI S I
Sbjct:   23 LVYISHNFKGKLIPSLFSICGQRLVSSGVMGGQDSQPGMWPWQVNIRSQ----------------SGGFCGGSLITSKWVVSAAHCC-DRSV-------------VYEIGGAVSLIIRQAEYGTH--------RQGREVKNFIIHPNYTAA----ENGSDICLMELGTELNFTQYIAPVCLPASGVTFPTGLPCWVTGWGEPAFNGESESVPLIGSQDCNNYYASH--PYIKDDMIC-AGNVSGGKGS--CQGDSGGPLVCAEA---DRWFLVGIVSFGL--SCQQPNYPEVYGRINGFLDWITSSI 277
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BLAST of Cystinosin vs. Ensembl Xenopus
Match: trmt9b (tRNA methyltransferase 9B (putative) [Source:Xenbase;Acc:XB-GENE-5952997])

HSP 1 Score: 89.7373 bits (221), Expect = 1.142e-18
Identity = 82/283 (28.98%), Postives = 128/283 (45.23%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI--DDYF-PDLLPIAS-DTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF------IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINS 1623
            +IIGG   +   WP IVS++ +              S   HFC GT+++S WVVTAA CF     NK ++  +  +   +              LS+    L  D ++ R I+ +++H  Y    G  +  YD+AL++L  PI  ++Y  P   P  S        C+ AGWGV +    E S   +E  V L+P   C         I+   +C  G+ EG  + D C  D+GGPL+C       D+ + G+ S      C    + GIY+++  + +WIN+
Sbjct:   42 RIIGGINAQPGAWPWIVSIQYKK------------ESNYAHFCGGTILNSQWVVTAAHCFS--HFNKKLHGLRMVFGAHK--------------LSE----LGPD-TQTRKIKKLIVHEEYS---GEGKQIYDMALVRLDEPITFNNYIQPACFPSKSIKVEHMTKCQVAGWGVLS----EKSDILQEASVTLIPNTLCNSKDWYNGKIEEYNLCA-GHKEG--KIDSCQGDSGGPLMCRTKS--NDFAVVGVTS--WGSGCARQQRPGIYSSIQYFTEWINT 277
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BLAST of Cystinosin vs. Ensembl Xenopus
Match: trmt9b (tRNA methyltransferase 9B (putative) [Source:Xenbase;Acc:XB-GENE-5952997])

HSP 1 Score: 89.3521 bits (220), Expect = 1.461e-18
Identity = 82/285 (28.77%), Postives = 129/285 (45.26%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI--DDYF-PDLLPIAS-DTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF------IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            +IIGG   +   WP IVS++ +              S   HFC GT+++S WVVTAA CF     NK ++  +  +   +              LS+    L  D ++ R I+ +++H  Y    G  +  YD+AL++L  PI  ++Y  P   P  S        C+ AGWGV      ES+   +E  V L+P   C         I+   +C  G+ EG  + D C  D+GGPL+C       D+ + G+ S      C    + GIY+++  + +WIN+ +
Sbjct:   21 RIIGGINAQPGAWPWIVSIQYKK------------ESNYAHFCGGTILNSQWVVTAAHCFS--HFNKKLHGLRMVFGAHK--------------LSE----LGPD-TQTRKIKKLIVHEEYS---GEGKQIYDMALVRLDEPITFNNYIQPACFPSKSIKVEHMTKCQVAGWGVLT---KESADILQEASVTLIPNTLCNSKDWYNGKIEEYNLCA-GHKEG--KIDSCQGDSGGPLMCRT--KSNDFAVVGVTS--WGSGCARQQRPGIYSSIQYFTEWINTKL 259
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BLAST of Cystinosin vs. Ensembl Xenopus
Match: pcdh8l (protocadherin-8-like [Source:Xenbase;Acc:XB-GENE-11536541])

HSP 1 Score: 86.6557 bits (213), Expect = 5.137e-18
Identity = 81/298 (27.18%), Postives = 120/298 (40.27%), Query Frame = 1 
Query:  793 IYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASDTNS-----SLHCKTAGWG-VSNVNDYESSGEFREFDVNLLPAKYCA----------PFIKPLE---ICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            +  K+I+GG   +   WP  +SL  +                 G  C G+L++  WV+TAA CF    V+K        Y  V +L                    D D +  R ++NI +HP YM          DIALI+L  PI  + P + P+   +          C   GWG +      E     ++ +V L+    C           P I  ++   IC  G  +G  + D C  D+GGPL+C+       W   GI+S  L   C +P+Q G+YTNV  Y  WI  ++
Sbjct:   21 VMSKRIVGGTDSEEGEWPWQISLEFEG----------------GFLCGGSLLTDSWVLTAAHCFDSMNVSKYT-----AYLGVYQLS-------------------DLDNAVLRGVKNITVHPDYMYEGSSG----DIALIELEEPI-VFTPSIQPVCLPSQDVPLPMGTMCWVTGWGNIKENTPLEDPQTLQKAEVGLINRTSCEAMYQSSLGYRPSIHLIQDDMIC-AGYKQG--KIDACQGDSGGPLVCNT---SNTWLQFGIVSWGL--GCAEPNQPGVYTNVQYYLTWIQELV 265
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BLAST of Cystinosin vs. Ensembl Mouse
Match: Ctns (cystinosis, nephropathic [Source:MGI Symbol;Acc:MGI:1932872])

HSP 1 Score: 166.777 bits (421), Expect = 4.359e-46
Identity = 97/214 (45.33%), Postives = 139/214 (64.95%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW++SFYPQ++ N++RKSVIGL+FDFL  N+TGF+AYS+FN  L +   +Q+EF   Y    NPV  ND FFS++A+ + LIV +QC +Y RGNQ++S     F+ L  ++ L++ ++          +WL  L   SY+KL  T+IKY PQ  MN+  +ST GWSI  V  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIGLLWVPYIQEEFLLKYPNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGFLVLAWLFVLVTMIVAA----VGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKSTKGWSIGGVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. Ensembl Mouse
Match: Ctns (cystinosis, nephropathic [Source:MGI Symbol;Acc:MGI:1932872])

HSP 1 Score: 166.777 bits (421), Expect = 4.359e-46
Identity = 97/214 (45.33%), Postives = 139/214 (64.95%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW++SFYPQ++ N++RKSVIGL+FDFL  N+TGF+AYS+FN  L +   +Q+EF   Y    NPV  ND FFS++A+ + LIV +QC +Y RGNQ++S     F+ L  ++ L++ ++          +WL  L   SY+KL  T+IKY PQ  MN+  +ST GWSI  V  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIGLLWVPYIQEEFLLKYPNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGFLVLAWLFVLVTMIVAA----VGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKSTKGWSIGGVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
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BLAST of Cystinosin vs. Ensembl Mouse
Match: Prss12 (protease, serine 12 neurotrypsin (motopsin) [Source:MGI Symbol;Acc:MGI:1100881])

HSP 1 Score: 93.2041 bits (230), Expect = 2.475e-19
Identity = 84/303 (27.72%), Postives = 128/303 (42.24%), Query Frame = 1 
Query:  757 IFSTLQIFMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDD-------YFPDLLPI--ASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIKPL---EICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            + S+     L +  +K+IIGG       WP   SLR       L+S +          C  TL+SS WV+TAA CF      K       +YA               + + DY   + E+  +   ++ IV+H  Y      ++  YDIAL++L  P +          P  LP+       ++ +C   GWG +       S   ++  V LLP ++C    K L    +   GN++ + R D C  D+GGPL+C +   D  W ++G+ S      CG  D  G+YT V  +  WI SV 
Sbjct:  500 MLSSGCGLRLLHRRQKRIIGGNNSLRGAWPWQASLR-------LRSAH----GDGRLLCGATLLSSCWVLTAAHCF------KRYGNNSRSYA---------------VRVGDYHTLVPEEFEQEIGVQQIVIHRNYR----PDRSDYDIALVRLQGPGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWGDTG---RAYSRTLQQAAVPLLPKRFCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKP--DESWVVYGVTSWGY--GCGVKDTPGVYTRVPAFVPWIKSVT 759
[Close]
BLAST of Cystinosin vs. Ensembl Mouse
Match: Prss30 (protease, serine 30 [Source:MGI Symbol;Acc:MGI:1353645])

HSP 1 Score: 90.1225 bits (222), Expect = 2.576e-19
Identity = 83/291 (28.52%), Postives = 122/291 (41.92%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI--DDYFPDLLPIA-SDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF-------------IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            KI+GG+      WP  VSL               + ++ GH C G+LI   WV+TAA CF+ + +N       F + KV  L                 + L E  S   ++ NI +HP Y+ +   +    DIAL++L  P+    + P  LP A +       C   GWG +   D  S    +E  V LL ++ C                I+   +C  G +EG +  D C  D+GGPL+CS    +  W   GI S  +   C  P + G+YT V  Y  WI  ++
Sbjct:   36 KIVGGQDALEGQWPWQVSL---------------WITEDGHICGGSLIHEVWVLTAAHCFR-RSLNP-----SFYHVKVGGLT----------------LSLLEPHSTLVAVRNIFVHPTYLWA---DASSGDIALVQLDTPLRPSQFTPVCLPAAQTPLTPGTVCWVTGWGATQERDMASV--LQELAVPLLDSEDCEKMYHTQGSSLSGERIIQSDMLC-AGYVEGQK--DSCQGDSGGPLVCS---INSSWTQVGITSWGI--GCARPYRPGVYTRVPTYVDWIQRIL 276
[Close]
BLAST of Cystinosin vs. Ensembl Mouse
Match: Prss30 (protease, serine 30 [Source:MGI Symbol;Acc:MGI:1353645])

HSP 1 Score: 90.1225 bits (222), Expect = 2.576e-19
Identity = 83/291 (28.52%), Postives = 122/291 (41.92%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI--DDYFPDLLPIA-SDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF-------------IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            KI+GG+      WP  VSL               + ++ GH C G+LI   WV+TAA CF+ + +N       F + KV  L                 + L E  S   ++ NI +HP Y+ +   +    DIAL++L  P+    + P  LP A +       C   GWG +   D  S    +E  V LL ++ C                I+   +C  G +EG +  D C  D+GGPL+CS    +  W   GI S  +   C  P + G+YT V  Y  WI  ++
Sbjct:   36 KIVGGQDALEGQWPWQVSL---------------WITEDGHICGGSLIHEVWVLTAAHCFR-RSLNP-----SFYHVKVGGLT----------------LSLLEPHSTLVAVRNIFVHPTYLWA---DASSGDIALVQLDTPLRPSQFTPVCLPAAQTPLTPGTVCWVTGWGATQERDMASV--LQELAVPLLDSEDCEKMYHTQGSSLSGERIIQSDMLC-AGYVEGQK--DSCQGDSGGPLVCS---INSSWTQVGITSWGI--GCARPYRPGVYTRVPTYVDWIQRIL 276
[Close]
BLAST of Cystinosin vs. UniProt/SwissProt
Match: sp|Q9VCR7|CTNS_DROME (Cystinosin homolog OS=Drosophila melanogaster OX=7227 GN=CG17119 PE=1 SV=2)

HSP 1 Score: 180.644 bits (457), Expect = 4.210e-50
Identity = 105/225 (46.67%), Postives = 148/225 (65.78%), Query Frame = 1 
Query:  175 MTLHKS---LWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIA--LICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEKKI-IGGKPMK 831
            +T+ KS   ++ + +FGW+YF+AW++SFYPQI  NY+RKSV GLNFDFL  NI GF  YS+FN  LYF ++LQ E+   Y    NPV LND+ FS++A+F   I  +QCF Y R  Q++S   FIA  ++ I++++  ++   L   S + WL  L   SY+KL  T+IKY+PQ +MN+ R+STSGWSI N+  D TGG  S LQ+ + A+ Y+  + I G P K
Sbjct:  120 VTVAKSRALIYTSIIFGWVYFVAWSVSFYPQIWSNYRRKSVEGLNFDFLALNIVGFTLYSMFNCGLYFIEDLQNEYEVRYPLGVNPVMLNDVVFSLHAMFATCITILQCFFYQRAQQRVS---FIAYGILAIFAVV-VVVSAGLAGGSVIHWLDFLYYCSYVKLTITIIKYVPQALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNAHNYDDWVSIFGDPTK 340
[Close]
BLAST of Cystinosin vs. UniProt/SwissProt
Match: sp|A7MB63|CTNS_BOVIN (Cystinosin OS=Bos taurus OX=9913 GN=CTNS PE=2 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 7.890e-46
Identity = 92/223 (41.26%), Postives = 145/223 (65.02%), Query Frame = 1 
Query:  172 YMTLHKSL--WIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            ++ +H ++   I  + GW+YF+AW++SFYPQ++ N++RKSV+GL+FDF+  N+ GF+AYS+FN  L++  +++++F   Y    NPV  ND+FFS++A+ + L+V +QC +Y RG+Q++S      L+   S +  LI   +      +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  115 FLVIHSNIVSIINQVIGWIYFVAWSVSFYPQVITNWRRKSVVGLSFDFVVLNLMGFVAYSVFNIGLFWVPSIKEQFLLKYPNGVNPVDSNDVFFSLHAVALTLVVIVQCLLYERGSQRVSWLAISFLVL--SWLFTLIALIMAAVGATTWLQFLFCFSYIKLAVTLVKYFPQAYMNFHYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. UniProt/SwissProt
Match: sp|Q54WT7|CTNS_DICDI (Cystinosin homolog OS=Dictyostelium discoideum OX=44689 GN=ctns PE=3 SV=1)

HSP 1 Score: 165.622 bits (418), Expect = 9.938e-46
Identity = 101/209 (48.33%), Postives = 144/209 (68.90%), Query Frame = 1 
Query:  214 GWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISR-GCFIALICIYSLMSALIVCKLTEFSNV-SWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFM-LAYIYEKKIIGGKPMK 831
            GW+YF  W++SFYPQ++LN+++K+VIGL+FDFL +NITG+  YS+FNS LYF+K ++ E+Y  Y G   PVQ +D+ F+I+   +  I  IQCFIY+RGNQK S+ G  IA +    +  +LIV  +  FSNV +WL ++   SY+KLF T IKY+PQ  +N+  +STSGWS+ NV  D +GG+ S LQ+F+ +A      I  G P+K
Sbjct:   12 GWIYFACWSLSFYPQVILNFRKKNVIGLSFDFLLFNITGYACYSVFNSVLYFDKLVKNEYYDKY-GPPIPVQQSDIAFAIHGFVLTAITIIQCFIYDRGNQKNSKLGIGIATL----IWVSLIVMTILGFSNVFTWLWVINYYSYVKLFITFIKYIPQAYLNFKNKSTSGWSVHNVLLDFSGGVLSLLQMFLDVADSGNWNIFTGDPVK 215
[Close]
BLAST of Cystinosin vs. UniProt/SwissProt
Match: sp|O60931|CTNS_HUMAN (Cystinosin OS=Homo sapiens OX=9606 GN=CTNS PE=1 SV=2)

HSP 1 Score: 166.777 bits (421), Expect = 2.868e-45
Identity = 92/214 (42.99%), Postives = 141/214 (65.89%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ+++N++RKSVIGL+FDF+  N+TGF+AYS+FN  L +   ++++F   Y    NPV  ND+FFS++A+ + LI+ +QC +Y RG Q++S     F+ L  +++ ++ ++          +WL  L   SY+KL  T++KY PQ  MN+  +ST GWSI NV  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAA----VGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. UniProt/SwissProt
Match: sp|P57757|CTNS_MOUSE (Cystinosin OS=Mus musculus OX=10090 GN=Ctns PE=1 SV=1)

HSP 1 Score: 166.777 bits (421), Expect = 3.049e-45
Identity = 97/214 (45.33%), Postives = 139/214 (64.95%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW++SFYPQ++ N++RKSVIGL+FDFL  N+TGF+AYS+FN  L +   +Q+EF   Y    NPV  ND FFS++A+ + LIV +QC +Y RGNQ++S     F+ L  ++ L++ ++          +WL  L   SY+KL  T+IKY PQ  MN+  +ST GWSI  V  D TGG FS LQ+F+ +Y  ++  +I G P K
Sbjct:  126 INQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIGLLWVPYIQEEFLLKYPNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGFLVLAWLFVLVTMIVAA----VGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKSTKGWSIGGVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTK 335
[Close]
BLAST of Cystinosin vs. TrEMBL
Match: K1QPD1 (Cystinosin OS=Crassostrea gigas OX=29159 GN=CGI_10007548 PE=4 SV=1)

HSP 1 Score: 187.963 bits (476), Expect = 8.371e-52
Identity = 107/214 (50.00%), Postives = 145/214 (67.76%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ+  N++RKSV+GLNFDFL YNITGF+ Y  FN  +Y+  N++ E+   +    NPVQLND+ F+++A+F+ +I  IQCFIY+RG+QKIS+ C   I+L  ++ +++  +V        +SWL  L   SY+KL  T+IKY+PQ  MN  RQST GWSI NV  D TGG FS LQ+F+LAY  E    I G P K
Sbjct:   14 INSIIGWIYFVAWSISFYPQVFENWRRKSVVGLNFDFLLYNITGFLVYGFFNVGMYWVDNVKDEYMSQHPRGINPVQLNDVIFTLHAVFVTIITIIQCFIYDRGSQKISKFCLTLISLAWLFIIVTLFVVIFGDNL--ISWLQYLYYFSYIKLGVTIIKYIPQAWMNCQRQSTLGWSIGNVLLDFTGGSFSLLQMFLLAYNNEDWSSIFGDPTK 225
[Close]
BLAST of Cystinosin vs. TrEMBL
Match: A0A0R3SKD7 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 PE=4 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 2.355e-51
Identity = 103/203 (50.74%), Postives = 138/203 (67.98%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEKK 807
            +  + GW YF+AW +SFYPQI+LN +RKSV GL+FDF+ YN+ GF+ YSIFN  LYF   +Q+E++  Y     PVQLNDLFFS++AL + L+V +QCF+Y RG QK+S  C   LI I  L+       L  F+ ++WL+   L SY+KL  T+IKY+PQ I+N  R+S  GWS+ NV  D  GGIFS LQ+F++AY   KK
Sbjct:   56 LQQIVGWTYFLAWTLSFYPQIILNCRRKSVEGLSFDFIVYNVIGFLCYSIFNIGLYFIPLIQEEYFNIYPLGVIPVQLNDLFFSVHALVITLVVVVQCFLYERGTQKVSMLC--KLITILMLIFIAFSGMLATFNCITWLSAFYLFSYVKLIVTLIKYVPQAILNCRRRSCVGWSLGNVILDFVGGIFSILQMFIIAYNCGKK 256
[Close]
BLAST of Cystinosin vs. TrEMBL
Match: A0A3P6ZJK1 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS5400 PE=4 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 2.643e-51
Identity = 103/203 (50.74%), Postives = 138/203 (67.98%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEKK 807
            +  + GW YF+AW +SFYPQI+LN +RKSV GL+FDF+ YN+ GF+ YSIFN  LYF   +Q+E++  Y     PVQLNDLFFS++AL + L+V +QCF+Y RG QK+S  C   LI I  L+       L  F+ ++WL+   L SY+KL  T+IKY+PQ I+N  R+S  GWS+ NV  D  GGIFS LQ+F++AY   KK
Sbjct:   56 LQQIVGWTYFLAWTLSFYPQIILNCRRKSVEGLSFDFIVYNVIGFLCYSIFNIGLYFIPLIQEEYFNIYPLGVIPVQLNDLFFSVHALVITLVVVVQCFLYERGTQKVSMLC--KLITILMLIFIAFSGMLATFNCITWLSAFYLFSYVKLIVTLIKYVPQAILNCRRRSCVGWSLGNVILDFVGGIFSILQMFIIAYNCGKK 256
[Close]
BLAST of Cystinosin vs. TrEMBL
Match: A0A2B4RU17 (Cystinosin OS=Stylophora pistillata OX=50429 GN=CTNS PE=4 SV=1)

HSP 1 Score: 189.889 bits (481), Expect = 3.829e-51
Identity = 97/198 (48.99%), Postives = 136/198 (68.69%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAY 792
            I  + GWLYF+AW+ISFYPQ  LN+KRKSV+GLNFDFL YN+TGF+AY  FN  +++   +Q+E++  + G  NPVQ ND+FF+++A+ + +I   QCFIY RG+QK+S    + L   +   +  +V  +     + WLT L   SY+K+  T+IKY+PQ  MN+ RQST+GWSI N+  D TGG  S LQ+F+LAY
Sbjct:  125 INQVIGWLYFVAWSISFYPQAFLNWKRKSVVGLNFDFLAYNLTGFLAYGFFNVGMFWVHEVQREYFAKHPGGVNPVQANDVFFTVHAVVLTVITIFQCFIYERGDQKVSLISKVLLSGTWLFAAVALVVTICH--KIEWLTYLYYFSYIKIGVTLIKYIPQAWMNYRRQSTAGWSIGNILLDFTGGSLSILQMFLLAY 320
[Close]
BLAST of Cystinosin vs. TrEMBL
Match: K1QAH4 (Cystinosin OS=Crassostrea gigas OX=29159 GN=CGI_10021597 PE=4 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 5.433e-51
Identity = 107/214 (50.00%), Postives = 145/214 (67.76%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGC--FIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ+  N++RKSV+GLNFDFL YNITGF+ Y  FN  +Y+  N++ E+   +    NPVQLND+ F+++A+F+ +I  IQCFIY+RG+QKIS+ C   I+L  ++ +++  +V        +SWL  L   SY+KL  T+IKY+PQ  MN  RQST GWSI NV  D TGG FS LQ+F+LAY  E    I G P K
Sbjct:  159 INSIIGWIYFVAWSISFYPQVFENWRRKSVVGLNFDFLLYNITGFLVYGFFNVGMYWVDNVKDEYMSQHPRGINPVQLNDVIFTLHAVFVTIITIIQCFIYDRGSQKISKFCLTLISLAWLFIIVTLFVVIFGDNL--ISWLQYLYYFSYIKLGVTIIKYIPQAWMNCQRQSTLGWSIGNVLLDFTGGSFSLLQMFLLAYNNEDWSSIFGDPTK 370
[Close]
BLAST of Cystinosin vs. Ensembl Cavefish
Match: ctns (cystinosin, lysosomal cystine transporter [Source:NCBI gene;Acc:103043999])

HSP 1 Score: 179.489 bits (454), Expect = 7.939e-51
Identity = 100/214 (46.73%), Postives = 142/214 (66.36%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISR--GCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ   N++RKSV+GLNFDFL  N TGFIAYS+FN  L++   +++EF +T     NPV  ND+FFS++AL + L+   QC +Y RG Q++SR   C +A+   ++ ++  I         ++WLT L   SY+KL  T++KY+PQ  MN+ R+ST GWSI NV  D TGG FS LQ+F+ +Y  ++ K+I G P K
Sbjct:  131 INQIIGWIYFLAWSISFYPQAYENWRRKSVVGLNFDFLALNFTGFIAYSVFNIGLFWIPYIKEEFIQTEPNGVNPVDANDVFFSVHALALTLVYICQCVLYERGGQRVSRVAMCLLAIGWTFAFVTLFIAVG----KKITWLTYLYYFSYIKLGVTLVKYIPQAYMNYKRKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDEWKLIFGDPTK 340
[Close]
BLAST of Cystinosin vs. Ensembl Cavefish
Match: ctns (cystinosin, lysosomal cystine transporter [Source:NCBI gene;Acc:103043999])

HSP 1 Score: 179.489 bits (454), Expect = 7.939e-51
Identity = 100/214 (46.73%), Postives = 142/214 (66.36%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISR--GCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            I  + GW+YF+AW+ISFYPQ   N++RKSV+GLNFDFL  N TGFIAYS+FN  L++   +++EF +T     NPV  ND+FFS++AL + L+   QC +Y RG Q++SR   C +A+   ++ ++  I         ++WLT L   SY+KL  T++KY+PQ  MN+ R+ST GWSI NV  D TGG FS LQ+F+ +Y  ++ K+I G P K
Sbjct:  131 INQIIGWIYFLAWSISFYPQAYENWRRKSVVGLNFDFLALNFTGFIAYSVFNIGLFWIPYIKEEFIQTEPNGVNPVDANDVFFSVHALALTLVYICQCVLYERGGQRVSRVAMCLLAIGWTFAFVTLFIAVG----KKITWLTYLYYFSYIKLGVTLVKYIPQAYMNYKRKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDEWKLIFGDPTK 340
[Close]
BLAST of Cystinosin vs. Ensembl Cavefish
Match: ENSAMXT00000033802.1 (pep primary_assembly:Astyanax_mexicanus-2.0:3:21891941:21894733:1 gene:ENSAMXG00000030254.1 transcript:ENSAMXT00000033802.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 97.4413 bits (241), Expect = 4.871e-22
Identity = 83/284 (29.23%), Postives = 125/284 (44.01%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI---DDYFPDLLPIASDT-NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF----IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            KI+GG   ++  WP  VSL+ +               + GH C  +L+ + W+++AA CFQD +           Y+  R  R  +   V  MN +        + +  R I  IV H +Y          YDIAL++L  P+   D   P  +P  S    S   C   GWGV  + + E +   +E  V+++  K C       + P  IC  GNI+G    D C  D+GGPL+C E G    W L GI+S      C   ++ G+YT V+ +  WI+   +
Sbjct:   52 KIVGGTDAQAGSWPWQVSLQME---------------RYGHVCGASLVGTRWLLSAAHCFQDSDA---------IYSDARAWRAFLGMRV--MNTA-------SNAAATRQIRRIVQHAQYDQFTS----DYDIALLELSAPVFFNDLVQPVCVPAPSHAFTSGTTCFVTGWGV--LTEEELATLLQEATVSIISHKTCNKMYDDAVTPRMIC-AGNIQGG--VDACQGDSGGPLVCLERGR--RWFLAGIVS--WGEGCARQNRPGVYTQVIKFTDWIHQQTK 289
[Close]
BLAST of Cystinosin vs. Ensembl Cavefish
Match: ENSAMXT00000049242.1 (trypsin-3-like [Source:NCBI gene;Acc:107197367])

HSP 1 Score: 82.4185 bits (202), Expect = 3.323e-17
Identity = 76/294 (25.85%), Postives = 127/294 (43.20%), Query Frame = 1 
Query:  778 FMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGY--DIALIKLGNP--IDDYF-PDLLPIASDT---NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLL--PAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            F++     ++IIGG               Q+ +PY++K           H+C G LI   WV++AA C++   + +++                         LS++ + +++   +  ++  I+++P +      N   Y  DI +IKL  P  ++ Y  P  LP  SDT   +S   C  +GWGV+ +  +  S   R  DV+ +     Y A  +    +C      G    D C  D+GGPL+C       +  L GI+S  +   C +P   G+YT V  + KWIN+VI
Sbjct:   23 FIIRETLPQRIIGG---------------QEVVPYSIK-YQASLQQDRNHYCGGILIHPQWVLSAAHCWRPSNIIQVV-------------------------LSEHNLAVEDGFEQVFNVSKIIVNPAF------NSKTYSSDIMMIKLSRPAMLNAYVQPASLP-DSDTSPLDSRTTCTVSGWGVTRIYTFYLSPVLRAVDVDFIYNCNVYLASRVNEFMMCAGSRFGGK---DSCQGDSGGPLVC-------NGNLEGIVSWGI--GCANPYYPGVYTRVRSFGKWINTVI 256
[Close]
BLAST of Cystinosin vs. Ensembl Cavefish
Match: ENSAMXT00000055380.1 (trypsin-3-like [Source:NCBI gene;Acc:107197367])

HSP 1 Score: 82.4185 bits (202), Expect = 3.577e-17
Identity = 76/294 (25.85%), Postives = 127/294 (43.20%), Query Frame = 1 
Query:  778 FMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGY--DIALIKLGNP--IDDYF-PDLLPIASDT---NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLL--PAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            F++     ++IIGG               Q+ +PY++K           H+C G LI   WV++AA C++   + +++                         LS++ + +++   +  ++  I+++P +      N   Y  DI +IKL  P  ++ Y  P  LP  SDT   +S   C  +GWGV+ +  +  S   R  DV+ +     Y A  +    +C      G    D C  D+GGPL+C       +  L GI+S  +   C +P   G+YT V  + KWIN+VI
Sbjct:   31 FIIRETLPQRIIGG---------------QEVVPYSIK-YQASLQQDRNHYCGGILIHPQWVLSAAHCWRPSNIIQVV-------------------------LSEHNLAVEDGFEQVFNVSKIIVNPAF------NSKTYSSDIMMIKLSRPAMLNAYVQPASLP-DSDTSPLDSRTTCTVSGWGVTRIYTFYLSPVLRAVDVDFIYNCNVYLASRVNEFMMCAGSRFGGK---DSCQGDSGGPLVC-------NGNLEGIVSWGI--GCANPYYPGVYTRVRSFGKWINTVI 264
[Close]
BLAST of Cystinosin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009198.1 (pep scaffold:Pmarinus_7.0:GL478809:48449:57757:-1 gene:ENSPMAG00000008291.1 transcript:ENSPMAT00000009198.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 89.7373 bits (221), Expect = 2.438e-20
Identity = 78/298 (26.17%), Postives = 127/298 (42.62%), Query Frame = 1 
Query:  790 YIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID-DYFPDLLPIASD-TNSSLHCKTAGWGVSNVNDYESSGEFREFDVNL------------LPAKYCAPFIKPLEICG----VGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            Y+YE  I+GG    +   P  VSL            NI Y     HFC G+LISS+WVV+AA C+     +++                        + + ++ +   E   +W      + HP+Y+ +   N    DI LIKL +P   + +   +P+ S    + + C  +GWG +  +  E +      +V +            +  K+      P +I      +G +EG +  D C +D+GGP++C       + +L GI+S   RG C  P+  G+YT V  YN WI S +
Sbjct:   18 YMYEDHIVGGSECAAHSQPWQVSL------------NIGY-----HFCGGSLISSEWVVSAAHCYMPPSASRI-----------------------SVRIGEHNIFASEGTEQWIQASKAIPHPQYLSATTDN----DIMLIKLSSPATLNQYAQAVPLPSSCVGTGVMCTISGWGETQTSVGEDTIFKNPINVGVRRNGCRLCVYITVLGKHSCRNSYPGDITNNMICLGYLEGGK--DACKYDSGGPVVC-------NGQLQGIVSWG-RG-CALPNSPGVYTKVCNYNSWITSTM 260
[Close]
BLAST of Cystinosin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009255.1 (pep scaffold:Pmarinus_7.0:GL478809:312976:317334:-1 gene:ENSPMAG00000008369.1 transcript:ENSPMAT00000009255.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.9669 bits (219), Expect = 2.580e-20
Identity = 78/283 (27.56%), Postives = 120/283 (42.40%), Query Frame = 1 
Query:  790 YIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID-DYFPDLLPIASD-TNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIKP-LEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            Y+YE  I+GG    +   P  VSL            NI Y     HFC G+LISS+WVV+AA C+                         M      + + ++ +   E   +W      + HP+Y  +   N    DI LIKL +P   + +   +P+ S    + + C  +GWG +  +  E +   R          Y  P  +P ++IC   N+  N  +    +D+GGP++C       + +L GI+S   RG C  P+  G+YT V  YN WI S +
Sbjct:   18 YMYEDHIVGGSECAAHSQPWQVSL------------NIGY-----HFCGGSLISSEWVVSAAHCY-------------------------MPAPSISVRIGEHNIFASEGTEQWIQASKAIPHPQYHSATTDN----DIMLIKLSSPATLNQYAQAVPLPSSCVGTGVMCTISGWGETQTSVGEDTTSCRN--------SY--PGARPNVDICT--NVAPNSSASL-QYDSGGPVVC-------NGQLQGIVSWG-RG-CALPNSPGVYTKVCNYNSWIASTM 232
[Close]
BLAST of Cystinosin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009246.1 (pep scaffold:Pmarinus_7.0:GL478809:273932:277386:-1 gene:ENSPMAG00000008356.1 transcript:ENSPMAT00000009246.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 84.3445 bits (207), Expect = 7.758e-19
Identity = 72/282 (25.53%), Postives = 113/282 (40.07%), Query Frame = 1 
Query:  790 YIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID-DYFPDLLPIASD-TNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            Y+YE  I+GG    +   P  VSL            NI Y     HFC G+LISS+WVV+AA C+       +                        + + ++ +   E   +W      + HP+Y  +   N    DI LIKL +P   + +   +P+ S    + + C  +GWG +  +  E +   R   +     +   P + P +                  D+GGP++C       + +L GI+S   RG C  P+  G+YT V  YN WI S +
Sbjct:   18 YMYEDHIVGGSECAAHSQPWQVSL------------NIGY-----HFCGGSLISSEWVVSAAHCYMPPSAPSI-----------------------SVRIGEHNIFASEGTEQWIQASKAIPHPQYHSATTDN----DIMLIKLSSPATLNQYAQAVPLPSSCVGTGVMCTISGWGETQTSVGEDTALRRPSTLENTSCRNSYPGMPPPQ-----------------GDSGGPVVC-------NGQLQGIVSWG-RG-CALPNYPGVYTKVCNYNSWIASTM 229
[Close]
BLAST of Cystinosin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009166.1 (pep scaffold:Pmarinus_7.0:GL478809:41377:44387:-1 gene:ENSPMAG00000008288.1 transcript:ENSPMAT00000009166.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 80.4925 bits (197), Expect = 2.136e-17
Identity = 75/290 (25.86%), Postives = 117/290 (40.34%), Query Frame = 1 
Query:  790 YIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID-DYFPDLLPIASD-TNSSLHCKTAGWGVSNVNDYESS--------GEFREFDVNLLPAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            Y+YE  I+GG    +   P  VSL            NI Y     HFC G+LISS+WVV+AA C+     + +                        + + ++ +   E   +W      + HP+Y+ +   N    DI LIKL +P   + +   +P+ S    + + C  +GWG +  +  E +        G+ R +   L+P         PL                   D+GGP++C       + +L GI+S   RG C  P+  G+YT V  YN WI S +
Sbjct:   18 YMYEDHIVGGSECAAHSQPWQVSL------------NIGY-----HFCGGSLISSEWVVSAAHCYMPPSASSI-----------------------SVRIGEHNIFTSEGTEQWIQASKAIPHPQYLSATTDN----DIMLIKLSSPATLNQYAQAVPLPSSCVGTGVMCTISGWGETETSIGEDTTSCRNSYPGDVRCWSQLLIP--------DPL-----------TPDAATQNDSGGPVVC-------NGQLQGIVSWG-RG-CALPNYPGVYTKVCNYNSWIASTM 235
[Close]
BLAST of Cystinosin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009259.1 (pep scaffold:Pmarinus_7.0:GL478809:471847:475891:1 gene:ENSPMAG00000008373.1 transcript:ENSPMAT00000009259.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 80.4925 bits (197), Expect = 2.586e-17
Identity = 80/286 (27.97%), Postives = 123/286 (43.01%), Query Frame = 1 
Query:  790 YIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID-DYFPDLLPIASD-TNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC----APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            Y+YE  I+GG    +   P  VSL            NI Y     HFC G+LISS+WVV+AA C+Q             T +++             + + ++ + + E   +       + HP+Y  +   N    DI LIKL +P   + +   +P+ S    + + C  +GWG +  +   S          +L    C       I    IC +G +EG +  D C  D+GGP++C       + +L GI+S   RG C  P+  G+YT V  YN WI S +
Sbjct:   16 YMYEDHIVGGYECAAHSQPWQVSL------------NIGY-----HFCGGSLISSEWVVSAAHCYQ-------------TASRI------------SVRIGEHNIFVTEGTEQRIQASKAIRHPQYSSATIDN----DIMLIKLSSPATLNQYAQAVPLPSSCVGTGVMCTISGWGETQTS-VGSPDVLMCVQAPVLSDTSCRNSYPGDITNNMIC-LGYLEGGK--DSCQGDSGGPVVC-------NGQLQGIVSWG-RG-CALPNYPGVYTKVCNYNSWIASTM 242
[Close]
BLAST of Cystinosin vs. Ensembl Yeast
Match: ERS1 (Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS [Source:SGD;Acc:S000000671])

HSP 1 Score: 58.9214 bits (141), Expect = 3.568e-10
Identity = 60/207 (28.99%), Postives = 102/207 (49.28%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITG--FIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNR-------GNQKISR---GCFIALICIYSLMSALIVCK--LTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQI 777
            + D+ G +Y  +W+IS YP I+ N++ KS   ++ DF+  N  G  ++  SIF   LY  K    E   +  G+    Q  D ++ ++   M +++  Q     R       G++K++       +A + I+SL++   +      ++ N   L     L  LK+  ++IKY+PQV  N  R+S   + I  VF D+TGGI S LQ+
Sbjct:    4 LDDILGIVYVTSWSISMYPPIITNWRHKSASAISMDFVMLNTAGYSYLVISIF-LQLYCWKMTGDE---SDLGRPKLTQF-DFWYCLHGCLMNVVLLTQVVAGARIWRFPGKGHRKMNPWYLRILLASLAIFSLLTVQFMYSNYWYDWHNSRTLAYCNNLFLLKISMSLIKYIPQVTHNSTRKSMDCFPIQGVFLDVTGGIASLLQL 205
[Close]
BLAST of Cystinosin vs. Ensembl Nematostella
Match: EDO46894 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNQ1])

HSP 1 Score: 182.956 bits (463), Expect = 6.289e-54
Identity = 98/199 (49.25%), Postives = 142/199 (71.36%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIAL-ICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAY 792
            I  + GW+YF AW++SFYPQ++LN+KRKSVIGLNFDF+ YN+TGF+AY +FN  +++   +QQ++   +    NPVQ ND+FF+++A+ + +I  IQ  IY RG+Q++S+ C + +  C+   + AL V   T F+ ++WLT L   SY+K+  T+IKY+PQ  MN+ R+ST GWSI NV  D TGG FS LQ+F+LAY
Sbjct:   21 INAVIGWIYFAAWSVSFYPQVILNWKRKSVIGLNFDFVCYNLTGFVAYGLFNIGMFWIPLVQQQYEAKHPNGVNPVQTNDVFFTLHAIVLTIITGIQACIYERGDQRVSKVCMVLVGGCVLFSVVALFV---TIFNEITWLTYLYYFSYIKIGVTLIKYIPQAYMNYRRKSTVGWSIGNVLLDFTGGSFSLLQMFLLAY 216
[Close]
BLAST of Cystinosin vs. Ensembl Nematostella
Match: EDO34987 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMR9])

HSP 1 Score: 132.494 bits (332), Expect = 3.288e-35
Identity = 80/194 (41.24%), Postives = 114/194 (58.76%), Query Frame = 1 
Query:  199 IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSAL-IVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQI 777
            +AD+FGW YF+AW +SFYPQI  N++RK V+GL+FD + Y +  +IAY I+N  ++F+ N+Q E       + +PV+L D+ F+I  L    I  +QC IY  G QKI    F   +     + AL I C L  F   SWL +L    Y+KL  +   YLPQ+ +N+ R+ T G+ I  V  D +GGI S LQ+
Sbjct:   10 LADIFGWGYFLAWTVSFYPQIYENWRRKCVVGLSFDMMTYFMISYIAYMIYNVVVFFDLNIQWEIIGN-SNESSPVKLTDVVFAILGLVCTGITCLQCVIYESGPQKIH---FTTKVVFSVFVVALGICCALAGFKVTSWLFMLDYCGYVKLAVSFGSYLPQIWLNYRRKCTEGFHIGGVLLDFSGGILSLLQM 199
[Close]
BLAST of Cystinosin vs. Ensembl Nematostella
Match: EDO33274 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSS0])

HSP 1 Score: 100.523 bits (249), Expect = 1.312e-23
Identity = 84/292 (28.77%), Postives = 129/292 (44.18%), Query Frame = 1 
Query:  802 KKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYM-LSIGVN-------QPGYDIALIKLGNP---IDDYFP-DLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC-APFIKPLEICGVGNIEGNQRS--DFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            K+I+GG   ++  WP  V+L                       C G+LIS +WVV+AA CFQ   +++  N G           W +      +   D+F        + R + +I LHPRY   +I V         P YD+AL++L  P    +  +P  LLP  +      +C   GWGV      + +   RE  V L+P   C +P     E+ G     G +R   D C +D+GGPL C E    G W L G++S     +CG+P + G+Y ++   N W+ ++I+
Sbjct:   30 KRIVGGIESEADAWPWQVALLINGT----------------QMCGGSLISREWVVSAAHCFQGNGLSE--NPGD----------WEVTLGEHHLENVDWF-------EQSRRVRSIHLHPRYQEATITVEGHKARHVPPDYDVALLRLATPAKFTNYVYPICLLPQGARFRPGKYCYVTGWGVLQWKGTKPA-ILREAQVQLVPQDKCNSPQSYNGEVSGRALCAGFERGGVDACQYDSGGPLACEE---RGRWYLTGVVSYGH--ECGNPHKYGLYADMATLNTWVENIIQ 280
[Close]
BLAST of Cystinosin vs. Ensembl Nematostella
Match: EDO33256 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSR9])

HSP 1 Score: 88.1965 bits (217), Expect = 1.401e-19
Identity = 79/285 (27.72%), Postives = 114/285 (40.00%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRY----MLSIGVNQPGYDIALIKLGNPI---DDYFP-DLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC------APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWI 1617
            +I+GG   +   WP  V+L                      FC G+L++ +WVVTAA CF D            +Y+   +  W        + L ++ +   ED  + R I  I LH  Y    +  I    P +DIAL++L  P    ++  P  LLP          C   GWG    N  +     RE  V L+P   C         I    +C  G  EG    D C +D+GGPL C     DG W L G++S     +C  P + G+Y+N+     W+
Sbjct:    1 RIVGGVESRQGTWPWQVALLLNGT----------------QFCGGSLVTPEWVVTAAHCFHD------------SYSSTNEDHWT-------VTLGEHKLKDKEDFEQTRDISAIYLHEAYKSMFLEGIKDTPPDFDIALVRLSEPAIFDENVSPICLLPPEHKLPWGKTCIITGWGHIRWNGTQPEA-LREAKVRLVPTWVCNLVNSYNGTIHSRALC-AGFKEGG--VDACQYDSGGPLQCEH---DGRWYLTGLVS--WGHECARPQKYGVYSNMQVMTSWV 241
[Close]
BLAST of Cystinosin vs. Ensembl Nematostella
Match: EDO34066 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQF1])

HSP 1 Score: 85.5001 bits (210), Expect = 1.113e-18
Identity = 81/290 (27.93%), Postives = 126/290 (43.45%), Query Frame = 1 
Query:  799 EKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKR-MNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGY-DIALIKLGNPI---DDYFPDLLPIASDTN--SSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC------APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            E++IIGG+    + WP +V++                 + TGH+C G++I   WVVTA  C                      + W  + +  R +  +++     E   ++   + I LHP +++  GV+ PGY DIAL+ L  PI   D   P  LP   DT   +   C   GWG + ++    S   ++  V L+    C      +  I    +C  G  +G Q  D C  D+GGPL C      GDW L G++S   +  C  PD+ G+YT+V     +I S +
Sbjct:   13 EERIIGGQEAAKNTWPWMVTV-----------------NNTGHWCGGSIIDPHWVVTAGHCV---------------------VPWSPRAIGTRVLRFAEHDSSRMEGYEQYAIPDRIHLHPGFVIG-GVSHPGYYDIALLHLAKPIQFSDRIQPICLP-QDDTEFPAGKMCYLTGWGETVLDSGVFSPTLKQLKVPLVNKSVCNSNNSYSGIIHEQFMC-AGYNQGGQ--DGCLGDSGGPLSCQT--ESGDWVLTGLMSWGEK--CALPDKYGVYTDVRRMLPFIESTL 255
[Close]
BLAST of Cystinosin vs. Ensembl Medaka
Match: ctns (cystinosin, lysosomal cystine transporter [Source:NCBI gene;Acc:101155673])

HSP 1 Score: 177.563 bits (449), Expect = 6.208e-49
Identity = 99/223 (44.39%), Postives = 145/223 (65.02%), Query Frame = 1 
Query:  172 YMTLHKSLW--IADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYEK-KIIGGKPMK 831
            +M +H S+   ++ + GW+YF+AW++SFYPQ   N++RKSV+GLNFDFL  N+TGFIAYS+FN  L++   +Q+EF KT     NPV  ND+FFSI+AL +  +   Q  +Y RG+QK+S    + L+  ++   A I   L     ++WL  L   SY+KL  T++KY+PQ  MN+ R+ST GWSI NV  D TGG+ S LQ+ + +Y  ++ ++I G P K
Sbjct:  244 FMVIHSSVLSVLSQVIGWIYFVAWSVSFYPQAWENWRRKSVVGLNFDFLALNLTGFIAYSVFNIGLFWVPYVQEEFLKTNPNGINPVNSNDVFFSIHALLLCAVYVCQAVVYERGDQKVSWMAKLLLLIGWTF--AFISLFLAVAKQITWLDYLYYFSYIKLAVTLVKYVPQAYMNYRRKSTEGWSIGNVLLDFTGGVLSILQMIVQSYNNDEWRLIFGDPTK 464
[Close]
BLAST of Cystinosin vs. Ensembl Medaka
Match: ENSORLT00000010945.2 (pep primary_assembly:ASM223467v1:20:17371788:17374100:1 gene:ENSORLG00000008718.2 transcript:ENSORLT00000010945.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 96.2857 bits (238), Expect = 1.073e-21
Identity = 84/282 (29.79%), Postives = 125/282 (44.33%), Query Frame = 1 
Query:  805 KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLL-----PIASDT-NSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF----IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWIN 1620
            KI+GG    +  WP  VSL+ +               + GH C  TL+S+ W+++AA CFQD +           Y+     R  M   V  M   ++           R I  I+LHP+Y          YDIAL++L  P+  +F DL+     P +S T  +   C   GWGV  + + E +   +E  V ++  K C       + P  +C  GN++G    D C  D+GGPL+C E G    W L GI+S      C   ++ G+YT V+ +  WI 
Sbjct:   53 KIVGGSDALAGSWPWQVSLQME---------------RYGHVCGATLVSNRWLISAAHCFQDSDA---------IYSDPHAWRAYMGMRV--MARGNHGAAT-------RLIRRILLHPQYDQFTS----DYDIALLELSAPV--FFSDLVQPVCVPASSHTFTTGTSCYVTGWGV--LMEDELASRLQEASVKIINRKTCNKLYDDAVTPRMMC-AGNLQGG--VDACQGDSGGPLVCLERG--KRWFLAGIVS--WGEGCARQNRPGVYTQVVKFTDWIR 286
[Close]
BLAST of Cystinosin vs. Ensembl Medaka
Match: TMPRSS6 (transmembrane serine protease 6 [Source:NCBI gene;Acc:101162577])

HSP 1 Score: 92.8189 bits (229), Expect = 2.062e-19
Identity = 83/288 (28.82%), Postives = 116/288 (40.28%), Query Frame = 1 
Query:  796 YEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPD------LLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC----APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            +  +IIGGK      WP   SL+ +                  H C G LISS WVV+AA CF D  +          Y+      +L K  + R + +       E+ +R   +++I LH  Y          YD+AL+KL  P      +      L P        L C   GWG        +S   ++ DV L+  + C       I P  +C       N + D C  D+GGPL+C E    G W L G++S   RG CG PD  G+YT +     WI  +I
Sbjct:  549 FSSRIIGGKDASEGEWPWQASLQVRGT----------------HICGGALISSQWVVSAAHCFYDDRL----------YSPTMWTVYLGKLFLNRSSPT-------EEVAR---VQHIHLHQYY----DDESQDYDLALLKLDRPASALLAEHARPACLPPPTHQLEPDLLCWVTGWGALREGG-GASNVLQKVDVRLVSEEDCVRSYGHLISPRMLCAGYR---NGKKDSCQGDSGGPLVCQEA--SGRWFLAGVVSWG-RG-CGRPDNYGVYTRITRLTDWIKEII 788
[Close]
BLAST of Cystinosin vs. Ensembl Medaka
Match: TMPRSS6 (transmembrane serine protease 6 [Source:NCBI gene;Acc:101162577])

HSP 1 Score: 92.8189 bits (229), Expect = 2.072e-19
Identity = 83/288 (28.82%), Postives = 116/288 (40.28%), Query Frame = 1 
Query:  796 YEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPD------LLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC----APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVI 1629
            +  +IIGGK      WP   SL+ +                  H C G LISS WVV+AA CF D  +          Y+      +L K  + R + +       E+ +R   +++I LH  Y          YD+AL+KL  P      +      L P        L C   GWG        +S   ++ DV L+  + C       I P  +C       N + D C  D+GGPL+C E    G W L G++S   RG CG PD  G+YT +     WI  +I
Sbjct:  563 FSSRIIGGKDASEGEWPWQASLQVRGT----------------HICGGALISSQWVVSAAHCFYDDRL----------YSPTMWTVYLGKLFLNRSSPT-------EEVAR---VQHIHLHQYY----DDESQDYDLALLKLDRPASALLAEHARPACLPPPTHQLEPDLLCWVTGWGALREGG-GASNVLQKVDVRLVSEEDCVRSYGHLISPRMLCAGYR---NGKKDSCQGDSGGPLVCQEA--SGRWFLAGVVSWG-RG-CGRPDNYGVYTRITRLTDWIKEII 802
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BLAST of Cystinosin vs. Ensembl Medaka
Match: tmprss5 (transmembrane serine protease 5 [Source:NCBI gene;Acc:101167385])

HSP 1 Score: 88.5817 bits (218), Expect = 2.498e-19
Identity = 83/299 (27.76%), Postives = 122/299 (40.80%), Query Frame = 1 
Query:  772 QIFMLAYIYEK--KIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPI---DDYFPDLLP-IASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPF------IKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            ++ +L  I  K  +IIGG       WP  VSL               Y+S+  H C G++I+  W+VTAA C    E+        F  +     RW ++ ++   N +             R+ ++                  DIALIKL  P+   D   P  LP    D      C  +GWG +  +D +S    +E  V L+  K C         I P  +C  G  EG  + D C  D+GGPL+C E   D  W+L G++S      C +P+  G+YT V  +  WI  +I 
Sbjct:    9 RLLILQSITTKLPRIIGGAEAALGRWPWQVSLY--------------YSSR--HTCGGSIITRQWIVTAAHCHYRSEIQG------FNQSLTAVQRWKLEKIIYNKNYNH------------RTHDS------------------DIALIKLRTPLNFTDTIRPICLPQYKYDLPGGTQCWISGWGYTKPDDVQSPDTLKEAPVPLISTKKCNSSCMYNGEITPRMLCA-GYTEG--KVDACQGDSGGPLVCQE---DTVWRLVGVVSWGT--GCAEPNHPGVYTKVAEFLSWIYEMIE 247
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BLAST of Cystinosin vs. Planmine SMEST
Match: SMESG000016910.1 (SMESG000016910.1)

HSP 1 Score: 587.8 bits (1514), Expect = 0.000e+0
Identity = 280/292 (95.89%), Postives = 285/292 (97.60%), Query Frame = 1 
Query:  757 IFSTLQIFMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            I++ L+  + +   EKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR
Sbjct:   11 IYNLLESLVASSHIEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPIDDYFPDLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLLPAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 302
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BLAST of Cystinosin vs. Planmine SMEST
Match: SMESG000016911.1 (SMESG000016911.1)

HSP 1 Score: 386.341 bits (991), Expect = 2.559e-132
Identity = 208/209 (99.52%), Postives = 209/209 (100.00%), Query Frame = 1 
Query:  175 MTLHKSLWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYE 801
            MTLHKSLWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWLTILILLSYLKLFSTVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIY+
Sbjct:    1 MTLHKSLWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWLTILILLSYLKLFSTVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAYIYD 209
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BLAST of Cystinosin vs. Planmine SMEST
Match: SMESG000079054.1 (SMESG000079054.1)

HSP 1 Score: 167.162 bits (422), Expect = 1.223e-46
Identity = 91/203 (44.83%), Postives = 134/203 (66.01%), Query Frame = 1 
Query:  184 HKSLWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNITGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLLIVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWXXXXXXXXXXXXXXXVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQIFMLAY 792
            H  + + D+ GW YF++W ISFYPQ++LN ++KSV+GLNFDFL YN  GF +YS+FN  L++  +++  F        NPVQLND+ FS++A+ ++ I  IQC IY+R +QKIS+ C+    C+   +  +           +WL  +  +SYLKLF T+IKY+PQ +MN+ R+ST GWSI N+F D TGG  S +Q+ +L+Y
Sbjct:   86 HTLIILGDIIGWFYFVSWTISFYPQLILNIRKKSVVGLNFDFLIYNWIGFFSYSVFNIGLFWIDSIKNLFKYNNPRVANPVQLNDVIFSLHAILIVTIQLIQCCIYDRKDQKISKFCYSLASCMIIYIIIIASVAGAGVKKFTWLDFMFYISYLKLFITLIKYIPQAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSY 288
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BLAST of Cystinosin vs. Planmine SMEST
Match: SMESG000022862.1 (SMESG000022862.1)

HSP 1 Score: 102.834 bits (255), Expect = 6.475e-24
Identity = 97/300 (32.33%), Postives = 138/300 (46.00%), Query Frame = 1 
Query:  799 EKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHP-RYMLSIGVNQPGYDIALIKLGNPID-DYF--PDLLPIASDT-NSSLHCKTAGWGVSNVNDYESSGEF-REFDVNLLPAKYCA------------PF--IKPLEIC-GVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGD--PDQRGIYTNVMGYNKWINSVI 1629
            +K+I+GGK  + + WP +VSL       T K        K+ H C GTLIS  W++TAA CF+ K  N L N+           +W  +       L ++ +   ED     SI+ I +H  R++  +  N    DIAL+KL +P     F  P  LP   +  + +  C T GWG ++ N   S  E  R  ++ L+  +YC             PF  I P  +C G GN       D C FD+GGPL+C     D  W + GI+S   +  CG+  P   GIYT V  Y  WI+ +I
Sbjct:   54 DKRIMGGKESREAEWPWLVSLSLWKSDVTGKK-----PEKSEHMCGGTLISRSWILTAAHCFEKKWENSLTNDPS---------KWTAR-------LGEHNLIKTEDHQMDHSIKAIFIHESRHLTRLETND---DIALVKLESPAQFTRFIKPACLPNPDEKFHENTICTTIGWGFTSFNG--SIAEISRHVNLELVSHQYCKLLYDNLRIILDDPFYDILPSMLCAGRGN-----GKDACQFDSGGPLLCKSES-DNIWIVAGIVSFGFK--CGEIFP---GIYTRVSSYLDWISKII 316
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BLAST of Cystinosin vs. Planmine SMEST
Match: SMESG000055023.1 (SMESG000055023.1)

HSP 1 Score: 83.9593 bits (206), Expect = 1.507e-17
Identity = 86/297 (28.96%), Postives = 123/297 (41.41%), Query Frame = 1 
Query:  799 EKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTGHFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLVKRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLGNPID--DYFPDLLPIASDTNSSLH--CKTAGWGVSNVNDYESSGEFREFDVNLLPAKYC---------------APFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKLHGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR 1632
            +K+I+GG   K   WP +VSL  +  P     + I       H C GTLIS  WV+TAA CF+  E        K+         W ++     M L      +D +      ++ I +H +       +    DIAL+KL NPI   +Y         D N  +   C  AGWG  N ND   S   +   V ++  + C               A  I+   +C  G  EG +  D C FD+GGPL+C +   +  W + GIIS      CG     GIYT V  +  WI ++ +
Sbjct:   52 QKRIVGGVTTKQGEWPWLVSLMVRLKP----GLKI-------HLCGGTLISRQWVLTAAHCFEPHE--------KYPTLSTNPEIWTVRVGEHDM-LKQDIPHVDVE------VQKIYIHYKR-----TDTNSNDIALMKLKNPITLTEYANAACLPNLDENPKIREICFAAGWGHKNENDTAISTILQHVAVPIVANRDCNLNYGQLRTQLGPQYALDIEDTMVCA-GVDEGGK--DACQFDSGGPLMCKK---NNQWLVSGIISFGF--GCGKAYYPGIYTRVPSFISWIQNITK 309
The following BLAST results are available for this feature:
BLAST of Cystinosin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CTNS4.988e-4642.99cystinosin, lysosomal cystine transporter [Source:... [more]
CTNS5.971e-4642.99cystinosin, lysosomal cystine transporter [Source:... [more]
CTNS5.971e-4642.99cystinosin, lysosomal cystine transporter [Source:... [more]
CTNS3.382e-3541.15cystinosin, lysosomal cystine transporter [Source:... [more]
CTNS5.821e-3541.15cystinosin, lysosomal cystine transporter [Source:... [more]
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BLAST of Cystinosin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ctns-15.244e-4040.87Cystinosin homolog [Source:UniProtKB/Swiss-Prot;A... [more]
ctns-15.275e-4040.87Cystinosin homolog [Source:UniProtKB/Swiss-Prot;A... [more]
try-11.548e-1324.91TRYpsin-like protease [Source:UniProtKB/TrEMBL;Ac... [more]
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BLAST of Cystinosin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG171194.200e-5146.67gene:FBgn0039045 transcript:FBtr0084357[more]
CG171194.200e-5146.67gene:FBgn0039045 transcript:FBtr0344299[more]
CG60489.589e-1629.76gene:FBgn0029827 transcript:FBtr0070863[more]
Corin1.136e-1425.89gene:FBgn0033192 transcript:FBtr0088909[more]
Corin1.136e-1425.89gene:FBgn0033192 transcript:FBtr0336996[more]
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BLAST of Cystinosin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctns2.498e-4946.98cystinosin, lysosomal cystine transporter [Source:... [more]
CR352265.13.686e-2230.28pep chromosome:GRCz11:24:21813127:21819010:-1 gene... [more]
tmprss13b6.677e-1828.83transmembrane serine protease 13b [Source:ZFIN;Acc... [more]
tmprss13b7.883e-1828.83transmembrane serine protease 13b [Source:ZFIN;Acc... [more]
AL954146.13.233e-1728.41trypsin I-P1-like [Source:NCBI gene;Acc:560023][more]
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BLAST of Cystinosin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
klhl241.321e-4644.34kelch like family member 24 [Source:Xenbase;Acc:XB... [more]
ENSXETT00000016723.16.044e-1927.04pep primary_assembly:Xenopus_tropicalis_v9.1:9:244... [more]
trmt9b1.142e-1828.98tRNA methyltransferase 9B (putative) [Source:Xenba... [more]
trmt9b1.461e-1828.77tRNA methyltransferase 9B (putative) [Source:Xenba... [more]
pcdh8l5.137e-1827.18protocadherin-8-like [Source:Xenbase;Acc:XB-GENE-1... [more]
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BLAST of Cystinosin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ctns4.359e-4645.33cystinosis, nephropathic [Source:MGI Symbol;Acc:MG... [more]
Ctns4.359e-4645.33cystinosis, nephropathic [Source:MGI Symbol;Acc:MG... [more]
Prss122.475e-1927.72protease, serine 12 neurotrypsin (motopsin) [Sourc... [more]
Prss302.576e-1928.52protease, serine 30 [Source:MGI Symbol;Acc:MGI:135... [more]
Prss302.576e-1928.52protease, serine 30 [Source:MGI Symbol;Acc:MGI:135... [more]
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BLAST of Cystinosin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VCR7|CTNS_DROME4.210e-5046.67Cystinosin homolog OS=Drosophila melanogaster OX=7... [more]
sp|A7MB63|CTNS_BOVIN7.890e-4641.26Cystinosin OS=Bos taurus OX=9913 GN=CTNS PE=2 SV=1[more]
sp|Q54WT7|CTNS_DICDI9.938e-4648.33Cystinosin homolog OS=Dictyostelium discoideum OX=... [more]
sp|O60931|CTNS_HUMAN2.868e-4542.99Cystinosin OS=Homo sapiens OX=9606 GN=CTNS PE=1 SV... [more]
sp|P57757|CTNS_MOUSE3.049e-4545.33Cystinosin OS=Mus musculus OX=10090 GN=Ctns PE=1 S... [more]
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BLAST of Cystinosin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
K1QPD18.371e-5250.00Cystinosin OS=Crassostrea gigas OX=29159 GN=CGI_10... [more]
A0A0R3SKD72.355e-5150.74Uncharacterized protein OS=Hymenolepis diminuta OX... [more]
A0A3P6ZJK12.643e-5150.74Uncharacterized protein OS=Hymenolepis diminuta OX... [more]
A0A2B4RU173.829e-5148.99Cystinosin OS=Stylophora pistillata OX=50429 GN=CT... [more]
K1QAH45.433e-5150.00Cystinosin OS=Crassostrea gigas OX=29159 GN=CGI_10... [more]
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BLAST of Cystinosin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctns7.939e-5146.73cystinosin, lysosomal cystine transporter [Source:... [more]
ctns7.939e-5146.73cystinosin, lysosomal cystine transporter [Source:... [more]
ENSAMXT00000033802.14.871e-2229.23pep primary_assembly:Astyanax_mexicanus-2.0:3:2189... [more]
ENSAMXT00000049242.13.323e-1725.85trypsin-3-like [Source:NCBI gene;Acc:107197367][more]
ENSAMXT00000055380.13.577e-1725.85trypsin-3-like [Source:NCBI gene;Acc:107197367][more]
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BLAST of Cystinosin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000009198.12.438e-2026.17pep scaffold:Pmarinus_7.0:GL478809:48449:57757:-1 ... [more]
ENSPMAT00000009255.12.580e-2027.56pep scaffold:Pmarinus_7.0:GL478809:312976:317334:-... [more]
ENSPMAT00000009246.17.758e-1925.53pep scaffold:Pmarinus_7.0:GL478809:273932:277386:-... [more]
ENSPMAT00000009166.12.136e-1725.86pep scaffold:Pmarinus_7.0:GL478809:41377:44387:-1 ... [more]
ENSPMAT00000009259.12.586e-1727.97pep scaffold:Pmarinus_7.0:GL478809:471847:475891:1... [more]
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BLAST of Cystinosin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ERS13.568e-1028.99Protein involved in cystine transport; localizes t... [more]
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BLAST of Cystinosin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO468946.289e-5449.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO349873.288e-3541.24Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO332741.312e-2328.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO332561.401e-1927.72Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO340661.113e-1827.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cystinosin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctns6.208e-4944.39cystinosin, lysosomal cystine transporter [Source:... [more]
ENSORLT00000010945.21.073e-2129.79pep primary_assembly:ASM223467v1:20:17371788:17374... [more]
TMPRSS62.062e-1928.82transmembrane serine protease 6 [Source:NCBI gene;... [more]
TMPRSS62.072e-1928.82transmembrane serine protease 6 [Source:NCBI gene;... [more]
tmprss52.498e-1927.76transmembrane serine protease 5 [Source:NCBI gene;... [more]
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BLAST of Cystinosin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016910.10.000e+095.89SMESG000016910.1[more]
SMESG000016911.12.559e-13299.52SMESG000016911.1[more]
SMESG000079054.11.223e-4644.83SMESG000079054.1[more]
SMESG000022862.16.475e-2432.33SMESG000022862.1[more]
SMESG000055023.11.507e-1728.96SMESG000055023.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30034181 ID=SMED30034181|Name=Cystinosin|organism=Schmidtea mediterranea sexual|type=transcript|length=1657bp
ATTTAAATAGTTTAGCTTAAATTTTTTAAATTTAACAATTATCATAACAG
CATTCCATATATTCCATATTCCAACATCGGCTATTATAAGTTTATTTAAA
AGTCAAATTTTTATTGTGTATTAAAGAATAATAAATACTTTACAATGGTT
AGAAATTATGGAAGTTAAAGTTACATGACACTTCATAAATCTTTATGGAT
TGCTGACTTATTCGGCTGGCTATATTTTATTGCATGGGCAATATCGTTTT
ATCCTCAAATATTACTAAATTACAAAAGGAAAAGTGTTATTGGACTTAAT
TTTGACTTTCTCGGGTACAATATCACCGGATTCATCGCCTATTCCATTTT
TAATTCCGCGCTTTATTTCAATAAAAATCTTCAGCAAGAATTCTATAAAA
CATATAAAGGAAAATTTAATCCTGTGCAATTAAACGATCTATTTTTTTCA
ATAAATGCACTTTTCATGCTCCTTATCGTATCTATTCAGTGTTTTATTTA
TAACCGCGGCAATCAGAAAATCTCGAGGGGTTGCTTCATAGCGCTAATAT
GTATATACTCACTGATGTCGGCCCTTATAGTGTGTAAATTAACTGAGTTC
AGTAATGTTTCATGGCTAACAATTTTGATATTATTATCGTATCTAAAACT
ATTTAGCACAGTCATCAAATATTTGCCTCAAGTAATAATGAATTGGGATC
GACAAAGCACTTCCGGTTGGAGTATCATAAATGTCTTTTTTGATTTGACT
GGAGGAATTTTCAGTACTCTCCAGATATTCATGTTGGCTTATATCTATGA
AAAGAAAATTATTGGAGGCAAGCCAATGAAGTCATCTTACTGGCCAATGA
TCGTTTCCCTTCGTCAGCAAAATTTACCGTACACTCTAAAATCCATGAAT
ATTCCCTATACATCAAAGACTGGCCACTTTTGTGCAGGCACTTTGATAAG
TTCCGATTGGGTTGTAACAGCAGCGTGGTGTTTTCAGGATAAGGAAGTGA
ATAAACTTATAAATGAAGGGAAATTTACCTACGCAAAAGTACGAAAATTA
AGATGGTTAATGAAGACTTTAGTAAAACGAATGAATTTGAGCGATTATTT
TGTTTGTCTTGATGAAGATTGTTCTCGGTGGAGATCTATTGAAAATATCG
TCCTTCATCCGCGATATATGTTGTCGATTGGAGTCAACCAGCCAGGGTAT
GATATTGCATTAATCAAACTTGGAAACCCCATTGATGATTACTTTCCGGA
CCTATTACCAATTGCTTCTGACACTAATTCATCATTGCACTGCAAAACGG
CCGGCTGGGGAGTATCAAACGTGAATGATTATGAGAGCTCCGGTGAATTT
CGGGAATTCGATGTTAACTTACTCCCAGCAAAGTATTGCGCACCGTTTAT
TAAACCTTTGGAAATTTGCGGAGTTGGAAACATCGAAGGAAATCAAAGAT
CAGATTTTTGCTTTTTCGACACTGGAGGTCCGTTGATTTGCAGTGAGATC
GGTTTTGATGGCGACTGGAAACTTCATGGAATTATTTCAAGAGACTTGCG
AGGAGATTGTGGAGATCCAGATCAAAGAGGAATTTATACGAATGTCATGG
GATATAACAAGTGGATCAATTCCGTAATCAGATGAATATATGGAATAATA
ATTCATA
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protein sequence of SMED30034181-orf-1

>SMED30034181-orf-1 ID=SMED30034181-orf-1|Name=SMED30034181-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=487bp
MTLHKSLWIADLFGWLYFIAWAISFYPQILLNYKRKSVIGLNFDFLGYNI
TGFIAYSIFNSALYFNKNLQQEFYKTYKGKFNPVQLNDLFFSINALFMLL
IVSIQCFIYNRGNQKISRGCFIALICIYSLMSALIVCKLTEFSNVSWLTI
LILLSYLKLFSTVIKYLPQVIMNWDRQSTSGWSIINVFFDLTGGIFSTLQ
IFMLAYIYEKKIIGGKPMKSSYWPMIVSLRQQNLPYTLKSMNIPYTSKTG
HFCAGTLISSDWVVTAAWCFQDKEVNKLINEGKFTYAKVRKLRWLMKTLV
KRMNLSDYFVCLDEDCSRWRSIENIVLHPRYMLSIGVNQPGYDIALIKLG
NPIDDYFPDLLPIASDTNSSLHCKTAGWGVSNVNDYESSGEFREFDVNLL
PAKYCAPFIKPLEICGVGNIEGNQRSDFCFFDTGGPLICSEIGFDGDWKL
HGIISRDLRGDCGDPDQRGIYTNVMGYNKWINSVIR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000025nervous system
PLANA:0000099neuron
PLANA:0000418head
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR005282LC_transporter
IPR001314Peptidase_S1A
IPR001254Trypsin_dom
IPR006603PQ-loop_rpt
IPR009003Peptidase_S1_PA
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
Vocabulary: molecular function
TermDefinition
GO:0004252serine-type endopeptidase activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001314Peptidase S1A, chymotrypsin familyPRINTSPR00722CHYMOTRYPSINcoord: 339..353
score: 36.92
coord: 426..438
score: 49.11
coord: 254..269
score: 50.62
IPR001254Serine proteases, trypsin domainSMARTSM00020trypsin_2coord: 211..481
e-value: 2.1E-22
score: 90.4
IPR001254Serine proteases, trypsin domainPFAMPF00089Trypsincoord: 212..481
e-value: 4.8E-24
score: 85.4
IPR001254Serine proteases, trypsin domainPROSITEPS50240TRYPSIN_DOMcoord: 212..486
score: 24.16
IPR006603PQ-loop repeatSMARTSM00679ctnscoord: 164..195
e-value: 1.6E-10
score: 51.0
coord: 23..54
e-value: 5.3E-8
score: 42.6
IPR006603PQ-loop repeatPFAMPF04193PQ-loopcoord: 152..204
e-value: 8.0E-16
score: 57.6
coord: 10..67
e-value: 2.0E-17
score: 62.7
NoneNo IPR availableGENE3DG3DSA:2.40.10.10coord: 206..485
e-value: 2.3E-40
score: 140.5
NoneNo IPR availablePANTHERPTHR13131:SF5CYSTINOSINcoord: 9..210
NoneNo IPR availableTMHMMTMhelixcoord: 90..109
NoneNo IPR availableTMHMMTMhelixcoord: 180..202
NoneNo IPR availableTMHMMTMhelixcoord: 45..64
NoneNo IPR availableTMHMMTMhelixcoord: 10..32
NoneNo IPR availableTMHMMTMhelixcoord: 145..167
NoneNo IPR availableTMHMMTMhelixcoord: 116..135
IPR005282Lysosomal cystine transporterPANTHERPTHR13131CYSTINOSINcoord: 9..210
IPR009003Peptidase S1, PA clanSUPERFAMILYSSF50494Trypsin-like serine proteasescoord: 206..486