Myb-like domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30034140 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of Myb-like domain-containing protein vs. TrEMBL
Match: A0A0X3Q4M7 (Myb/SANT-like DNA-binding domain OS=Schistocephalus solidus OX=70667 GN=TR83036 PE=4 SV=1) HSP 1 Score: 133.265 bits (334), Expect = 1.962e-29 Identity = 59/100 (59.00%), Postives = 68/100 (68.00%), Query Frame = 3 Query: 213 SDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAV 512 +DKKVHW + VQ LLDCVE +HEF + HK VW IG EM+ GFSTEHCYNKWKNLRRDVR+ NP KA +N L RV +LI I PN D T + Sbjct: 91 TDKKVHWTTRNVQALLDCVEEHLHEFNVQKKHKAVWQAIGAEMEPLGFSTEHCYNKWKNLRRDVRLLVNNPMKAVRNASILRRVARLILVIYPNVDATTM 190
BLAST of Myb-like domain-containing protein vs. TrEMBL
Match: A0A3P7ENA6 (Myb-like domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS13906 PE=4 SV=1) HSP 1 Score: 133.265 bits (334), Expect = 2.466e-29 Identity = 59/100 (59.00%), Postives = 68/100 (68.00%), Query Frame = 3 Query: 213 SDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAV 512 +DKKVHW + VQ LLDCVE +HEF + HK VW IG EM+ GFSTEHCYNKWKNLRRDVR+ NP KA +N L RV +LI I PN D T + Sbjct: 102 TDKKVHWTTRNVQALLDCVEEHLHEFNVQKKHKAVWQAIGAEMEPLGFSTEHCYNKWKNLRRDVRLLVNNPMKAVRNASILRRVARLILVIYPNVDATTM 201
BLAST of Myb-like domain-containing protein vs. TrEMBL
Match: A0A183TBQ8 (Myb/SANT-like DNA-binding domain OS=Schistocephalus solidus OX=70667 PE=4 SV=1) HSP 1 Score: 133.265 bits (334), Expect = 2.466e-29 Identity = 59/100 (59.00%), Postives = 68/100 (68.00%), Query Frame = 3 Query: 213 SDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAV 512 +DKKVHW + VQ LLDCVE +HEF + HK VW IG EM+ GFSTEHCYNKWKNLRRDVR+ NP KA +N L RV +LI I PN D T + Sbjct: 102 TDKKVHWTTRNVQALLDCVEEHLHEFNVQKKHKAVWQAIGAEMEPLGFSTEHCYNKWKNLRRDVRLLVNNPMKAVRNASILRRVARLILVIYPNVDATTM 201
BLAST of Myb-like domain-containing protein vs. TrEMBL
Match: A0A3P7LJJ8 (Myb-like domain-containing protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS7828 PE=4 SV=1) HSP 1 Score: 133.265 bits (334), Expect = 3.763e-29 Identity = 59/100 (59.00%), Postives = 68/100 (68.00%), Query Frame = 3 Query: 213 SDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAV 512 +DKKVHW + VQ LLDCVE +HEF + HK VW IG EM+ GFSTEHCYNKWKNLRRDVR+ NP KA +N L RV +LI I PN D T + Sbjct: 88 TDKKVHWTTRNVQALLDCVEEHLHEFNVQKKHKAVWQAIGAEMEPLGFSTEHCYNKWKNLRRDVRLLVNNPMKAVRNASILRRVARLILVIYPNVDATTM 187
BLAST of Myb-like domain-containing protein vs. TrEMBL
Match: A0A0R3U635 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS2213 PE=4 SV=1) HSP 1 Score: 130.568 bits (327), Expect = 1.587e-28 Identity = 57/100 (57.00%), Postives = 68/100 (68.00%), Query Frame = 3 Query: 213 SDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAV 512 DKKVHW ++VQLLLD VE +HEF + HK VW IG EM+ YGF+TEHCYNKWKNLRRDVR+ NP K +N L +V +LI I PN D T + Sbjct: 88 GDKKVHWTTRHVQLLLDRVEEHLHEFNVQKKHKAVWQAIGAEMEPYGFTTEHCYNKWKNLRRDVRLLVNNPMKVVRNASILRQVARLILVIYPNVDATTM 187
BLAST of Myb-like domain-containing protein vs. Planmine SMEST
Match: SMESG000019869.1 (SMESG000019869.1) HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0 Identity = 355/357 (99.44%), Postives = 355/357 (99.44%), Query Frame = 3 Query: 81 MNEVAGELTXXXXXXXXXXSSKLEFVSASSSDIGTTDMQEKLVGSDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAVYKKSTKSPNKHSEESSNXXXXXXXXXXXXXXXXXDIMTPVNNENMDIQDGEAGVTTXXXXXXXXXXXXXXXXXXXXKQQQHNPGALLFHPNIAPNLFLNTDKDVYKDSNLKPLVSNIQCLQPKPDNSCNNKKPSILDDSADHNNRNSSSNYSTWPYELYDLLVSFRTEEVKQAHSIEQLIRQINEIRDSSVRRMNTIQQLMNLANLLINSKVS 1151 MNEVAGELTIINNNN NRISSKLEFVSASSSDIGTTDMQEKLVGSDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAVYKKSTKSPNKHSEESSNSLEPLTKLLTPPTSPFSDIMTPVNNENMDIQDGE GVTTDNSLLDMKLSLSSDVYSYLLKQQQHNPGALLFHPNIAPNLFLNTDKDVYKDSNLKPLVSNIQCLQPKPDNSCNNKKPSILDDSADHNNRNSSSNYSTWPYELYDLLVSFRTEEVKQAHSIEQLIRQINEIRDSSVRRMNTIQQLMNLANLLINSKVS Sbjct: 1 MNEVAGELTIINNNNDNRISSKLEFVSASSSDIGTTDMQEKLVGSDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYGFSTEHCYNKWKNLRRDVRMYAINPNKATKNQETLNRVKKLISTICPNFDPTAVYKKSTKSPNKHSEESSNSLEPLTKLLTPPTSPFSDIMTPVNNENMDIQDGEGGVTTDNSLLDMKLSLSSDVYSYLLKQQQHNPGALLFHPNIAPNLFLNTDKDVYKDSNLKPLVSNIQCLQPKPDNSCNNKKPSILDDSADHNNRNSSSNYSTWPYELYDLLVSFRTEEVKQAHSIEQLIRQINEIRDSSVRRMNTIQQLMNLANLLINSKVS 357
BLAST of Myb-like domain-containing protein vs. Planmine SMEST
Match: SMESG000016880.1 (SMESG000016880.1) HSP 1 Score: 102.834 bits (255), Expect = 7.347e-23 Identity = 51/116 (43.97%), Postives = 69/116 (59.48%), Query Frame = 3 Query: 213 SDKKVHWNCKYVQLLLDCVESRIHEFKNKSIHKKVWDDIGKEMQVYG-FSTEHCYNKWKNLRRDVRMYAIN---PNKATKNQETLNRVKKLISTIC-------------PNFDPTA 509 +KKVHWN V LLDC+E R+ +F+ KS+HK VW IGKEM G FS EHCYNKWKNLRRD+R+++ + +N + RV+++++ I PNFD A Sbjct: 82 GEKKVHWNPSQVHALLDCIEKRMSDFRRKSVHKSVWLAIGKEMSEQGEFSVEHCYNKWKNLRRDIRLFSSTNAMQKLSIRNTYIMERVQRMVNEIGYEGSSRKSSSPISPNFDLVA 197 HSP 2 Score: 59.6918 bits (143), Expect = 3.787e-9 Identity = 26/59 (44.07%), Postives = 44/59 (74.58%), Query Frame = 3 Query: 969 TWPYELYDLLVSFRTEEVKQAHSIEQLIRQINEIRDSSVRRMNTIQQLMNLANLLINSK 1145 +WP++LY+LL SFR EE +Q ++Q++ + +++S+ RR++TI QL++LA LLI K Sbjct: 433 SWPHQLYELLHSFRDEESRQMARLDQIVGYVQVMQESTKRRLSTINQLISLAGLLIPQK 491 The following BLAST results are available for this feature:
BLAST of Myb-like domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Myb-like domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Myb-like domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Myb-like domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30034140 ID=SMED30034140|Name=Myb-like domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1918bpback to top protein sequence of SMED30034140-orf-1 >SMED30034140-orf-1 ID=SMED30034140-orf-1|Name=SMED30034140-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=375bp MFRLSYKIVFYIIIPLQMNEVAGELTIINNNNVNRISSKLEFVSASSSDIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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