tlx

Overview


Name	tlx (AIX99548.1)
Smed ID	SMED30034115
Length (bp)	816

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of tlx (SMED30034115) t-SNE clustered cells

Violin plots show distribution of expression levels for tlx (SMED30034115) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of tlx (SMED30034115) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for tlx (SMED30034115) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30034115

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30034115	SMESG000017206.1	dd_Smed_v4_13781_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30034115	SMESG000017206.1	dd_Smed_v4_13781_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30034115	SMESG000017206.1	dd_Smed_v4_13781_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30034115	SMESG000017206.1	dd_Smed_v6_13781_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
dorsal ventral margin of the whole animal	SMED30034115	SMESG000017206.1	KJ934817	smed_ncbi_20200123	PMID:25254346 Scimone et al., 2014
midline	SMED30034115	SMESG000017206.1	KJ934817	smed_ncbi_20200123	PMID:25254346 Scimone et al., 2014
body wall musculature	SMED30034115	SMESG000017206.1	dd_Smed_v4_13781_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of tlx vs. Ensembl Human
Match: TLX3 (T cell leukemia homeobox 3 [Source:HGNC Symbol;Acc:HGNC:13532])

HSP 1 Score: 141.739 bits (356), Expect = 5.835e-40
Identity = 88/126 (69.84%), Postives = 101/126 (80.16%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ ASR +L LQ++     +N S  P      +S+L A+ NLQPW
Sbjct:  152 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPW 277

[Close]

BLAST of tlx vs. Ensembl Human
Match: TLX2 (T cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5057])

HSP 1 Score: 138.658 bits (348), Expect = 6.124e-39
Identity = 86/140 (61.43%), Postives = 100/140 (71.43%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSNNPSFNYT------SSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPKRKKPRTSF+R Q++ELERRF RQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAER  A R LL LQ +                  +S+L A+ NLQPWA    ++ +S   S
Sbjct:  143 RRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLAS 282

[Close]

BLAST of tlx vs. Ensembl Human
Match: TLX1 (T cell leukemia homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5056])

HSP 1 Score: 137.502 bits (345), Expect = 6.325e-38
Identity = 90/139 (64.75%), Postives = 103/139 (74.10%), Query Frame = 2

Query:  299 WIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN-------NPSFNYTSSTLSAISNLQPWA 694
            W+E  R+    R  GHPYQNRTPPK+KKPRTSF R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R LL LQ E  Q +       +P   + SS L A+ NLQPW+
Sbjct:  176 WMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSS-LFALQNLQPWS 313

[Close]

BLAST of tlx vs. Ensembl Human
Match: TLX1 (T cell leukemia homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5056])

HSP 1 Score: 126.331 bits (316), Expect = 1.736e-34
Identity = 60/81 (74.07%), Postives = 66/81 (81.48%), Query Frame = 2

Query:  299 WIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            W+E  R+    R  GHPYQNRTPPK+KKPRTSF R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKW
Sbjct:  176 WMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKW 256

[Close]

BLAST of tlx vs. Ensembl Human
Match: BARHL2 (BarH like homeobox 2 [Source:HGNC Symbol;Acc:HGNC:954])

HSP 1 Score: 77.0258 bits (188), Expect = 1.755e-15
Identity = 38/64 (59.38%), Postives = 49/64 (76.56%), Query Frame = 2

Query:  362 TPPKR-KKPR---TSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            +PP R KKPR   T+F+  Q+ +LER F RQKYL+  +R DLA  L++TD+QVKTW+QNRRTKW
Sbjct:  224 SPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKW 287

[Close]

BLAST of tlx vs. Ensembl Celegans
Match: ceh-9 (Homeobox protein ceh-9 [Source:UniProtKB/Swiss-Prot;Acc:P56407])

HSP 1 Score: 81.2629 bits (199), Expect = 7.076e-19
Identity = 37/65 (56.92%), Postives = 51/65 (78.46%), Query Frame = 2

Query:  347 PYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            P +     KRKK RT+F+ +Q+ ELE++F  +KYL+SS+R +LAK LD+T++QVK WFQNRRTKW
Sbjct:   61 PIEKCQKTKRKKARTTFSGKQVFELEKQFEAKKYLSSSDRSELAKRLDVTETQVKIWFQNRRTKW 125

[Close]

BLAST of tlx vs. Ensembl Celegans
Match: cog-1 (COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2])

HSP 1 Score: 72.4034 bits (176), Expect = 4.008e-16
Identity = 31/57 (54.39%), Postives = 45/57 (78.95%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++K+ R +F   QI +LER+F + KYLA ++R  LA++L+M++SQVK WFQNRRTKW
Sbjct:   18 QKKQSRPTFTGHQIYQLERKFEQTKYLAGADRAQLAQELNMSESQVKVWFQNRRTKW 74

[Close]

BLAST of tlx vs. Ensembl Celegans
Match: ceh-30 (Homeobox protein ceh-30 [Source:UniProtKB/Swiss-Prot;Acc:Q22909])

HSP 1 Score: 73.9442 bits (180), Expect = 1.648e-15
Identity = 35/69 (50.72%), Postives = 47/69 (68.12%), Query Frame = 2

Query:  335 RVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            R+G P   +   K +K RT F  +Q+ ELE  F +QKYL+  +R DLA  + +TD+QVKTW+QNRRTKW
Sbjct:   85 RMGSPGSCK---KSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLTDTQVKTWYQNRRTKW 150

[Close]

Query:  335 RVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            R+G P   +   K +K RT F  +Q+ ELE  F +QKYL+  +R DLA  + +TD+QVKTW+QNRRTKW
Sbjct:   85 RMGSPGSCK---KSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLTDTQVKTWYQNRRTKW 150

[Close]

BLAST of tlx vs. Ensembl Celegans
Match: cog-1 (COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2])

HSP 1 Score: 74.3294 bits (181), Expect = 1.897e-15
Identity = 31/57 (54.39%), Postives = 45/57 (78.95%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++K+ R +F   QI +LER+F + KYLA ++R  LA++L+M++SQVK WFQNRRTKW
Sbjct:  168 QKKQSRPTFTGHQIYQLERKFEQTKYLAGADRAQLAQELNMSESQVKVWFQNRRTKW 224

[Close]

BLAST of tlx vs. Ensembl Fly
Match: C15 (gene:FBgn0004863 transcript:FBtr0084111)

HSP 1 Score: 139.813 bits (351), Expect = 4.697e-39
Identity = 84/129 (65.12%), Postives = 100/129 (77.52%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-INQSNNP-------SFNYTSSTLSAISNLQPWA 694
            RR+GHPYQNRTPPKRKKPRTSF R Q+ ELE+RFH+QKYLAS+ER  LA+ L MTD+QVKTWFQNRRTKWRRQT+EEREAERQAA+R +L+LQ E I++   P             + L+A+  LQPWA
Sbjct:  203 RRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEAISKGFAPPSAPLGSQGGVNGAPLAALHGLQPWA 331

[Close]

BLAST of tlx vs. Ensembl Fly
Match: B-H1 (gene:FBgn0011758 transcript:FBtr0074430)

HSP 1 Score: 76.6406 bits (187), Expect = 1.698e-15
Identity = 33/57 (57.89%), Postives = 43/57 (75.44%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K++K RT+F   Q+  LE+ F RQKYL+  ER +LA  LD++D QVKTW+QNRRTKW
Sbjct:  298 KQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKW 354

[Close]

BLAST of tlx vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0306742)

HSP 1 Score: 74.3294 bits (181), Expect = 1.215e-14
Identity = 33/57 (57.89%), Postives = 46/57 (80.70%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++KK RT+F  +QI ELE+ F  +KYL++SER ++AK L +T++QVK WFQNRRTKW
Sbjct:  392 RKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKW 448

[Close]

BLAST of tlx vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0347151)

HSP 1 Score: 74.3294 bits (181), Expect = 1.215e-14
Identity = 33/57 (57.89%), Postives = 46/57 (80.70%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++KK RT+F  +QI ELE+ F  +KYL++SER ++AK L +T++QVK WFQNRRTKW
Sbjct:  392 RKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKW 448

[Close]

BLAST of tlx vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0082942)

HSP 1 Score: 74.3294 bits (181), Expect = 1.215e-14
Identity = 33/57 (57.89%), Postives = 46/57 (80.70%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++KK RT+F  +QI ELE+ F  +KYL++SER ++AK L +T++QVK WFQNRRTKW
Sbjct:  392 RKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKW 448

[Close]

BLAST of tlx vs. Ensembl Zebrafish
Match: CABZ01067175.1 (T-cell leukemia homeobox protein 3-like [Source:NCBI gene;Acc:100008066])

HSP 1 Score: 142.895 bits (359), Expect = 5.217e-41
Identity = 88/128 (68.75%), Postives = 101/128 (78.91%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQ-------SNNPSFNYTSSTLSAISNLQPWA 694
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREA RQ A+R LL LQ +  Q       S++P     +S+L A+ NLQPWA
Sbjct:  115 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAGRQQANRMLLQLQADALQKSISESVSSDP-LCLHNSSLYALQNLQPWA 241

[Close]

BLAST of tlx vs. Ensembl Zebrafish
Match: tlx2 (T cell leukemia homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-020208-1])

HSP 1 Score: 142.895 bits (359), Expect = 1.644e-40
Identity = 89/140 (63.57%), Postives = 104/140 (74.29%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN------NPSFNYTSSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R +L LQ E  Q               +S+L A+ NLQPWA    ++ ++S  S
Sbjct:  168 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQQEAFQKTLSQPLQQDPLCLHNSSLYALQNLQPWAEDNKVTSVTSVAS 307

[Close]

BLAST of tlx vs. Ensembl Zebrafish
Match: tlx3b (T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-021021-1])

HSP 1 Score: 142.124 bits (357), Expect = 3.646e-40
Identity = 92/145 (63.45%), Postives = 108/145 (74.48%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN-------NPSFNYTSSTLSAISNLQPWAIPQLISEMSSETSSPGG 745
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R ++ LQ++  Q +       +P   + SS L A+ NLQPWA        S E+S  GG
Sbjct:  160 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMIQLQHDAFQKSLTDSVPTDPLCIHNSS-LFALQNLQPWA--------SEESSKLGG 295

[Close]

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN-------NPSFNYTSSTLSAISNLQPWAIPQLISEMSSETSSPGG 745
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R ++ LQ++  Q +       +P   + SS L A+ NLQPWA        S E+S  GG
Sbjct:  160 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMIQLQHDAFQKSLTDSVPTDPLCIHNSS-LFALQNLQPWA--------SEESSKLGG 295

[Close]

BLAST of tlx vs. Ensembl Zebrafish
Match: tlx2 (T cell leukemia homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-020208-1])

HSP 1 Score: 140.969 bits (354), Expect = 1.024e-39
Identity = 87/127 (68.50%), Postives = 98/127 (77.17%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN------NPSFNYTSSTLSAISNLQPWA 694
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R +L LQ E  Q               +S+L A+ NLQPWA
Sbjct:  168 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQQEAFQKTLSQPLQQDPLCLHNSSLYALQNLQPWA 294

[Close]

BLAST of tlx vs. Ensembl Xenopus
Match: soga1 (suppressor of glucose, autophagy associated 1 [Source:Xenbase;Acc:XB-GENE-6049995])

HSP 1 Score: 143.28 bits (360), Expect = 2.141e-41
Identity = 88/128 (68.75%), Postives = 99/128 (77.34%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN-------NPSFNYTSSTLSAISNLQPWA 694
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L M+DSQVKTWFQNRRTKWRRQT+E+REAERQ  SR +L LQ E  Q         +P   + SS L A+ NLQPWA
Sbjct:   92 RRIGHPYQNRTPPKRKKPRTSFSRLQICELEKRFHRQKYLASAERASLAKALRMSDSQVKTWFQNRRTKWRRQTAEDREAERQQTSRMMLQLQQEAYQKTVSQTLPRDPLCAHNSS-LCALQNLQPWA 218

[Close]

BLAST of tlx vs. Ensembl Xenopus
Match: ENSXETT00000011915.1 (T cell leukemia homeobox 1 [Source:NCBI gene;Acc:100494864])

HSP 1 Score: 142.895 bits (359), Expect = 2.616e-40
Identity = 93/140 (66.43%), Postives = 108/140 (77.14%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPK+KKPRTSF R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R LL LQ E     INQ   P      +S+L A+ NLQPW+    +S+++S TS
Sbjct:  168 RRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKTINQPLQPDPICLHNSSLYALQNLQPWS--DDMSKITSVTS 305

[Close]

BLAST of tlx vs. Ensembl Xenopus
Match: jup (junction plakoglobin [Source:Xenbase;Acc:XB-GENE-489397])

HSP 1 Score: 139.813 bits (351), Expect = 3.302e-39
Identity = 86/126 (68.25%), Postives = 101/126 (80.16%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R +L LQ++     ++ S  P      +S+L A+ NLQPW
Sbjct:  153 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQHDAFQKSLSDSIQPDPLCLHNSSLFALQNLQPW 278

[Close]

BLAST of tlx vs. Ensembl Xenopus
Match: BARHL2 (BarH like homeobox 2 [Source:NCBI gene;Acc:100493839])

HSP 1 Score: 77.411 bits (189), Expect = 1.089e-15
Identity = 38/64 (59.38%), Postives = 49/64 (76.56%), Query Frame = 2

Query:  362 TPPKR-KKPR---TSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            +PP R KKPR   T+F+  Q+ +LER F RQKYL+  +R DLA  L++TD+QVKTW+QNRRTKW
Sbjct:  203 SPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKW 266

[Close]

BLAST of tlx vs. Ensembl Xenopus
Match: BARHL2 (BarH like homeobox 2 [Source:NCBI gene;Acc:100493839])

HSP 1 Score: 77.0258 bits (188), Expect = 1.149e-15
Identity = 38/64 (59.38%), Postives = 49/64 (76.56%), Query Frame = 2

Query:  362 TPPKR-KKPR---TSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            +PP R KKPR   T+F+  Q+ +LER F RQKYL+  +R DLA  L++TD+QVKTW+QNRRTKW
Sbjct:  196 SPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKW 259

[Close]

BLAST of tlx vs. Ensembl Mouse
Match: Tlx3 (T cell leukemia, homeobox 3 [Source:MGI Symbol;Acc:MGI:1351209])

HSP 1 Score: 141.739 bits (356), Expect = 3.526e-40
Identity = 88/126 (69.84%), Postives = 101/126 (80.16%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ ASR +L LQ++     +N S  P      +S+L A+ NLQPW
Sbjct:  152 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPW 277

[Close]

BLAST of tlx vs. Ensembl Mouse
Match: Tlx2 (T cell leukemia, homeobox 2 [Source:MGI Symbol;Acc:MGI:1350935])

HSP 1 Score: 139.428 bits (350), Expect = 2.293e-39
Identity = 86/140 (61.43%), Postives = 100/140 (71.43%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSNNPSFNYT------SSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPKRKKPRTSF+R Q++ELERRF RQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAER  A R LL LQ +                  +S+L A+ NLQPWA    ++ +S   S
Sbjct:  143 RRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLAS 282

[Close]

BLAST of tlx vs. Ensembl Mouse
Match: Tlx1 (T cell leukemia, homeobox 1 [Source:MGI Symbol;Acc:MGI:98769])

HSP 1 Score: 137.117 bits (344), Expect = 5.779e-38
Identity = 90/139 (64.75%), Postives = 103/139 (74.10%), Query Frame = 2

Query:  299 WIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN-------NPSFNYTSSTLSAISNLQPWA 694
            W+E  R+    R  GHPYQNRTPPK+KKPRTSF R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R LL LQ E  Q +       +P   + SS L A+ NLQPW+
Sbjct:  179 WMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSS-LFALQNLQPWS 316

[Close]

BLAST of tlx vs. Ensembl Mouse
Match: Tlx2 (T cell leukemia, homeobox 2 [Source:MGI Symbol;Acc:MGI:1350935])

HSP 1 Score: 129.028 bits (323), Expect = 3.566e-36
Identity = 58/70 (82.86%), Postives = 64/70 (91.43%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            RR+GHPYQNRTPPKRKKPRTSF+R Q++ELERRF RQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKW
Sbjct:  143 RRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKW 212

[Close]

BLAST of tlx vs. Ensembl Mouse
Match: Barhl2 (BarH like homeobox 2 [Source:MGI Symbol;Acc:MGI:1859314])

HSP 1 Score: 77.411 bits (189), Expect = 9.001e-16
Identity = 34/57 (59.65%), Postives = 45/57 (78.95%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K +K RT+F+  Q+ +LER F RQKYL+  +R DLA  L++TD+QVKTW+QNRRTKW
Sbjct:  228 KPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKW 284

[Close]

BLAST of tlx vs. UniProt/SwissProt
Match: sp|O93367|TLX3_CHICK (T-cell leukemia homeobox protein 3 OS=Gallus gallus OX=9031 GN=TLX3 PE=2 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 7.955e-40
Identity = 88/126 (69.84%), Postives = 102/126 (80.95%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ ASR +L LQ++     +N+S  P      +S+L A+ NLQPW
Sbjct:  158 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNESIQPDPLCLHNSSLFALQNLQPW 283

[Close]

BLAST of tlx vs. UniProt/SwissProt
Match: sp|O55144|TLX3_MOUSE (T-cell leukemia homeobox protein 3 OS=Mus musculus OX=10090 GN=Tlx3 PE=2 SV=2)

HSP 1 Score: 141.739 bits (356), Expect = 2.466e-39
Identity = 88/126 (69.84%), Postives = 101/126 (80.16%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ ASR +L LQ++     +N S  P      +S+L A+ NLQPW
Sbjct:  152 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPW 277

[Close]

BLAST of tlx vs. UniProt/SwissProt
Match: sp|O43711|TLX3_HUMAN (T-cell leukemia homeobox protein 3 OS=Homo sapiens OX=9606 GN=TLX3 PE=1 SV=3)

HSP 1 Score: 141.739 bits (356), Expect = 2.802e-39
Identity = 88/126 (69.84%), Postives = 101/126 (80.16%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ ASR +L LQ++     +N S  P      +S+L A+ NLQPW
Sbjct:  152 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPW 277

[Close]

BLAST of tlx vs. UniProt/SwissProt
Match: sp|Q61663|TLX2_MOUSE (T-cell leukemia homeobox protein 2 OS=Mus musculus OX=10090 GN=Tlx2 PE=2 SV=1)

HSP 1 Score: 139.428 bits (350), Expect = 1.604e-38
Identity = 86/140 (61.43%), Postives = 100/140 (71.43%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSNNPSFNYT------SSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPKRKKPRTSF+R Q++ELERRF RQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAER  A R LL LQ +                  +S+L A+ NLQPWA    ++ +S   S
Sbjct:  143 RRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLAS 282

[Close]

BLAST of tlx vs. UniProt/SwissProt
Match: sp|O43763|TLX2_HUMAN (T-cell leukemia homeobox protein 2 OS=Homo sapiens OX=9606 GN=TLX2 PE=1 SV=2)

HSP 1 Score: 138.658 bits (348), Expect = 2.941e-38
Identity = 86/140 (61.43%), Postives = 100/140 (71.43%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSNNPSFNYT------SSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPKRKKPRTSF+R Q++ELERRF RQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAER  A R LL LQ +                  +S+L A+ NLQPWA    ++ +S   S
Sbjct:  143 RRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLAS 282

[Close]

BLAST of tlx vs. TrEMBL
Match: A0A0A1CQY5 (Tlx (Fragment) OS=Schmidtea mediterranea OX=79327 GN=tlx PE=2 SV=1)

HSP 1 Score: 224.942 bits (572), Expect = 2.077e-71
Identity = 132/132 (100.00%), Postives = 132/132 (100.00%), Query Frame = 2

Query:  146 SASFSIDGILSTXXXXXXXXXXXXXXXXXXXXXXXLKHLLSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            SASFSIDGILSTKKELSESIITSKSEESTKTHSNSLKHLLSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW
Sbjct:    1 SASFSIDGILSTKKELSESIITSKSEESTKTHSNSLKHLLSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 132

[Close]

BLAST of tlx vs. TrEMBL
Match: K1RAP6 (T-cell leukemia homeobox protein 3 OS=Crassostrea gigas OX=29159 GN=CGI_10020599 PE=4 SV=1)

HSP 1 Score: 152.91 bits (385), Expect = 1.668e-41
Identity = 94/137 (68.61%), Postives = 115/137 (83.94%), Query Frame = 2

Query:  299 WIEILRQDRYP--RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQS----NNPSFNYTSSTLSAISNLQPW 691
            W++ +R+DR+   RR+GHPYQNRTPPKRKKPRTSF+R QIMELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQAA+R +L+LQNE N++     +P    ++S+L A+ NLQPW
Sbjct:  122 WLD-MRRDRFGVTRRIGHPYQNRTPPKRKKPRTSFSRLQIMELEKRFHRQKYLASAERSTLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQNEANKTIYDVRDP-LCMSNSSLHALQNLQPW 256

[Close]

BLAST of tlx vs. TrEMBL
Match: A0A1S3GYP0 (T-cell leukemia homeobox protein 3 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106150476 PE=4 SV=1)

HSP 1 Score: 152.14 bits (383), Expect = 7.828e-41
Identity = 94/145 (64.83%), Postives = 116/145 (80.00%), Query Frame = 2

Query:  275 FPPSLPRHWIEILRQDRYP--RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQS---NNPSFNYTSSTLSAISNLQPWA 694
             PPSL   W+E  R+DR    RR+GHPYQNRTPPKRKKPRTSF+R QI+ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQAA+R++++LQ E +++          ++++L A+ NLQPWA
Sbjct:  129 LPPSLQFPWMEA-RKDRLTITRRIGHPYQNRTPPKRKKPRTSFSRLQIIELEKRFHRQKYLASAERSALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRFMMSLQAEASKTIYDTRDPLVLSNASLHALQNLQPWA 272

[Close]

BLAST of tlx vs. TrEMBL
Match: A0A345F2S4 (Tlx homeodomain protein (Fragment) OS=Euperipatoides rowelli OX=49087 GN=Tlx PE=2 SV=1)

HSP 1 Score: 149.828 bits (377), Expect = 1.349e-40
Identity = 96/152 (63.16%), Postives = 115/152 (75.66%), Query Frame = 2

Query:  263 LSTIFPPSLPRHWIEILR---QDRYP--RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQS---NNPSFNYTSSTLSAISNLQPWA 694
            L T FP      W+E  R   +DR    RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQAA+R++++L  E N+S   +  S    +++L A+ NLQPWA
Sbjct:   87 LQTSFP------WMEATRRLVKDRLTATRRIGHPYQNRTPPKRKKPRTSFSRMQICELEKRFHRQKYLASAERASLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRFMMSLHAEANKSIYDSRDSLCLNNASLHALQNLQPWA 232

[Close]

BLAST of tlx vs. TrEMBL
Match: X5JAI5 (Clawless OS=Euperipatoides kanangrensis OX=488523 GN=clawless PE=2 SV=1)

HSP 1 Score: 150.214 bits (378), Expect = 1.782e-40
Identity = 96/152 (63.16%), Postives = 115/152 (75.66%), Query Frame = 2

Query:  263 LSTIFPPSLPRHWIEILR---QDRYP--RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQS---NNPSFNYTSSTLSAISNLQPWA 694
            L T FP      W+E  R   +DR    RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQAA+R++++L  E N+S   +  S    +++L A+ NLQPWA
Sbjct:   93 LQTSFP------WMEATRRLVKDRLTATRRIGHPYQNRTPPKRKKPRTSFSRMQICELEKRFHRQKYLASAERASLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRFMMSLHAEANKSIYDSRDSICLNNASLHALQNLQPWA 238

[Close]

BLAST of tlx vs. Ensembl Cavefish
Match: ENSAMXT00000055288.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000111.1:341656:348959:-1 gene:ENSAMXG00000038858.1 transcript:ENSAMXT00000055288.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 144.436 bits (363), Expect = 1.582e-41
Identity = 90/127 (70.87%), Postives = 103/127 (81.10%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQ---SNNPSFN---YTSSTLSAISNLQPWA 694
            RRVGHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R LL LQ ++ Q   S + S +     +S+L A+ NLQPWA
Sbjct:  129 RRVGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRMLLQLQADVLQRSISESVSVDPMCVNNSSLYALQNLQPWA 255

[Close]

BLAST of tlx vs. Ensembl Cavefish
Match: tlx2 (T cell leukemia homeobox 2 [Source:NCBI gene;Acc:103046147])

HSP 1 Score: 143.665 bits (361), Expect = 9.165e-41
Identity = 90/140 (64.29%), Postives = 107/140 (76.43%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPWAIPQLISEMSSETS 733
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R +L LQ E     ++Q   P      +S+L A+ NLQPWA    ++ ++S  S
Sbjct:  166 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQQEAFQKTLSQPLQPDPLCLHNSSLYALQNLQPWAEDNKVTSVTSVAS 305

[Close]

BLAST of tlx vs. Ensembl Cavefish
Match: tlx3b (T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-021021-1])

HSP 1 Score: 142.51 bits (358), Expect = 1.043e-40
Identity = 89/138 (64.49%), Postives = 107/138 (77.54%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSN-------NPSFNYTSSTLSAISNLQPWAIPQLISEMSS 724
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ ASR +L LQ++  Q +       +P   + SS L A+ NLQPWA  +  +++ +
Sbjct:  143 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDALQKSLSDSVPADPLCIHNSS-LFALQNLQPWACGEEGTKLGA 279

[Close]

BLAST of tlx vs. Ensembl Cavefish
Match: tlx1 (T cell leukemia homeobox 1 [Source:NCBI gene;Acc:103034137])

HSP 1 Score: 141.354 bits (355), Expect = 4.715e-40
Identity = 91/138 (65.94%), Postives = 106/138 (76.81%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPWAI-PQLISEMSS 724
            RR+GHPYQNRTPPK+KKPRTSF R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R L+ LQ E     +NQ  +P      +S+L A+ NLQPW   P  I+ +SS
Sbjct:  160 RRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLLMQLQQEAFQKTLNQPVSPDPICLHNSSLFALHNLQPWTENPSKINSVSS 297

[Close]

BLAST of tlx vs. Ensembl Cavefish
Match: HMX2 (H6 family homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5018])

HSP 1 Score: 75.8702 bits (185), Expect = 1.841e-16
Identity = 34/56 (60.71%), Postives = 43/56 (76.79%), Query Frame = 2

Query:  374 RKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            RKK RT F+R Q+ +LE  FH ++YL+SSER  LA  L +T++QVKTWFQNRR KW
Sbjct:   55 RKKTRTVFSRTQVFQLETAFHTKRYLSSSERAGLASSLHLTETQVKTWFQNRRNKW 110

[Close]

BLAST of tlx vs. Ensembl Sea Lamprey
Match: tlx1 (T cell leukemia homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-021021-2])

HSP 1 Score: 127.872 bits (320), Expect = 1.085e-35
Identity = 63/84 (75.00%), Postives = 68/84 (80.95%), Query Frame = 2

Query:  299 WIEILR---QDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            W+E  R   +DR    VGHPYQNRTPPKRKKPRTSF R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKW
Sbjct:  204 WMESSRRFAKDRL--TVGHPYQNRTPPKRKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKW 285

[Close]

BLAST of tlx vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153])

HSP 1 Score: 72.4034 bits (176), Expect = 1.715e-16
Identity = 32/57 (56.14%), Postives = 44/57 (77.19%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K +K RT+F+  Q+ +LER F RQKYL+  +R +LA  L ++D+QVKTW+QNRRTKW
Sbjct:    4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKW 60

[Close]

BLAST of tlx vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153])

HSP 1 Score: 73.1738 bits (178), Expect = 1.775e-16
Identity = 32/57 (56.14%), Postives = 44/57 (77.19%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K +K RT+F+  Q+ +LER F RQKYL+  +R +LA  L ++D+QVKTW+QNRRTKW
Sbjct:    4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKW 60

[Close]

BLAST of tlx vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001141.1 (pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 gene:ENSPMAG00000001023.1 transcript:ENSPMAT00000001141.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.0922 bits (170), Expect = 8.362e-16
Identity = 31/57 (54.39%), Postives = 44/57 (77.19%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K ++PRT+F+ QQ++ELER F RQ+YL+  +R  +A  L +T++QVK WFQNRR KW
Sbjct:    2 KCRRPRTAFSSQQLLELERHFSRQRYLSRPQRFQVASALMLTETQVKIWFQNRRMKW 58

[Close]

BLAST of tlx vs. Ensembl Sea Lamprey
Match: hhex (pep scaffold:Pmarinus_7.0:GL476649:273574:289580:-1 gene:ENSPMAG00000009445.1 transcript:ENSPMAT00000010429.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:hhex)

HSP 1 Score: 73.559 bits (179), Expect = 9.857e-16
Identity = 35/65 (53.85%), Postives = 45/65 (69.23%), Query Frame = 2

Query:  347 PYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            P+  R   KRK  +  F+ +Q +ELER+F RQKYL+  ER  LAK L +++ QVKTWFQNRR KW
Sbjct:  134 PFLPRPAHKRKGGQVRFSSEQTVELERKFERQKYLSPGERKGLAKLLQLSERQVKTWFQNRRAKW 198

[Close]

BLAST of tlx vs. Ensembl Nematostella
Match: EDO34127 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQ94])

HSP 1 Score: 77.7962 bits (190), Expect = 8.491e-19
Identity = 36/55 (65.45%), Postives = 42/55 (76.36%), Query Frame = 2

Query:  374 RKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTK 538
            +KKPRT+F   QI ELE+RF  QKYL S ER +LA  L +TD+QVKTWFQNRR K
Sbjct:    1 KKKPRTAFTESQISELEKRFQSQKYLGSKERSELAGTLGLTDTQVKTWFQNRRMK 55

[Close]

BLAST of tlx vs. Ensembl Nematostella
Match: ANTH.HBXC.NV (NK-like 20; Predicted protein [Source:UniProtKB/TrEMBL;Acc:Q0N4G2])

HSP 1 Score: 73.1738 bits (178), Expect = 3.930e-17
Identity = 32/56 (57.14%), Postives = 45/56 (80.36%), Query Frame = 2

Query:  374 RKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            +KK RT+F  +QI ELE++F  +KYL ++ER D+A  L++T++QVK WFQNRRTKW
Sbjct:    1 KKKARTTFTGRQIFELEKQFEAKKYLTATERSDMASLLNVTETQVKIWFQNRRTKW 56

[Close]

BLAST of tlx vs. Ensembl Nematostella
Match: NK-3 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7L1])

HSP 1 Score: 77.7962 bits (190), Expect = 4.889e-17
Identity = 35/62 (56.45%), Postives = 46/62 (74.19%), Query Frame = 2

Query:  353 QNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTK 538
            Q ++ P+RK+ R +F+ QQ+ ELERRF  QKYL+  ER DLA  L +T++QVK WFQNRR K
Sbjct:  123 QQKSKPRRKRSRAAFSHQQVFELERRFSHQKYLSGPERADLAAALKLTETQVKIWFQNRRYK 184

[Close]

BLAST of tlx vs. Ensembl Nematostella
Match: EDO32495 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUX2])

HSP 1 Score: 68.9366 bits (167), Expect = 1.334e-15
Identity = 30/56 (53.57%), Postives = 42/56 (75.00%), Query Frame = 2

Query:  374 RKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            +K+PRT+F  +QI +LE  F + KYL+ S R +LA  L +T++Q+K WFQNRRTKW
Sbjct:    1 KKRPRTAFTNEQIKDLEAEFQKSKYLSVSRRMELANSLSLTETQIKIWFQNRRTKW 56

[Close]

BLAST of tlx vs. Ensembl Nematostella
Match: EDO48767 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI78])

HSP 1 Score: 68.5514 bits (166), Expect = 2.643e-15
Identity = 31/57 (54.39%), Postives = 42/57 (73.68%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++KK RT F+R Q+ +LE  F  ++YL+SSER  LA  L +T++QVK WFQNRR KW
Sbjct:    1 RKKKTRTVFSRSQVYQLESTFDMKRYLSSSERAGLASQLHLTETQVKIWFQNRRNKW 57

[Close]

BLAST of tlx vs. Ensembl Medaka
Match: tlx1 (T cell leukemia homeobox 1 [Source:NCBI gene;Acc:101163994])

HSP 1 Score: 142.895 bits (359), Expect = 1.252e-40
Identity = 89/126 (70.63%), Postives = 100/126 (79.37%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNE-----INQSNNPS-FNYTSSTLSAISNLQPW 691
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R L+ LQ E     INQ   P      +S+L A+ NLQPW
Sbjct:  152 RRIGHPYQNRTPPKRKKPRTSFSRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILMQLQQEAFQKTINQPVTPDPLCLQNSSLFALQNLQPW 277

[Close]

BLAST of tlx vs. Ensembl Medaka
Match: ENSORLT00000004940.2 (T cell leukemia homeobox 3 [Source:NCBI gene;Acc:101161249])

HSP 1 Score: 141.354 bits (355), Expect = 3.923e-40
Identity = 88/128 (68.75%), Postives = 100/128 (78.12%), Query Frame = 2

Query:  332 RRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQS-------NNPSFNYTSSTLSAISNLQPWA 694
            RR+GHPYQNRTPPKRKKPRTSF+R QI ELE+RFHRQKYLAS+ER  LAK L MTD+QVKTWFQNRRTKWRRQT+EEREAERQ A+R +L LQ    Q        ++P   + SS L A+ NLQPWA
Sbjct:  152 RRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLILQLQQSALQKSLSESAVSDPLCAHNSS-LYALQNLQPWA 278

[Close]

BLAST of tlx vs. Ensembl Medaka
Match: barhl2 (BarH like homeobox 2 [Source:NCBI gene;Acc:101174414])

HSP 1 Score: 76.6406 bits (187), Expect = 1.001e-15
Identity = 34/57 (59.65%), Postives = 44/57 (77.19%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K +K RT+F   Q+ +LER F RQKYL+  +R DLA  L++TD+QVKTW+QNRRTKW
Sbjct:  205 KPRKARTAFTDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKW 261

[Close]

BLAST of tlx vs. Ensembl Medaka
Match: ENSORLT00000038356.1 (barH-like 1 homeobox protein [Source:NCBI gene;Acc:100049373])

HSP 1 Score: 75.485 bits (184), Expect = 2.361e-15
Identity = 33/57 (57.89%), Postives = 44/57 (77.19%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            K +K RT+F   Q+ +LER F RQKYL+  +R +LA  L++TD+QVKTW+QNRRTKW
Sbjct:  172 KPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKW 228

[Close]

BLAST of tlx vs. Ensembl Medaka
Match: nkx6.1 (NK6 homeobox 1 [Source:NCBI gene;Acc:101156548])

HSP 1 Score: 73.9442 bits (180), Expect = 5.212e-15
Identity = 35/57 (61.40%), Postives = 40/57 (70.18%), Query Frame = 2

Query:  371 KRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            KRK  R +F+ QQI  LE+ F + KYLA  ER  LA  L MT+SQVK WFQNRRTKW
Sbjct:  163 KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKW 219

[Close]

BLAST of tlx vs. Planmine SMEST
Match: SMESG000017206.1 (SMESG000017206.1)

HSP 1 Score: 344.739 bits (883), Expect = 3.929e-121
Identity = 210/210 (100.00%), Postives = 210/210 (100.00%), Query Frame = 2

Query:  143 MSASFSIDGILSTXXXXXXXXXXXXXXXXXXXXXXXLKHLLSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSNNPSFNYTSSTLSAISNLQPWAIPQLISEMSSETSSPGGHIDDSHSEK 772
            MSASFSIDGILSTKKELSESIITSKSEESTKTHSNSLKHLLSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWRRQTSEEREAERQAASRYLLTLQNEINQSNNPSFNYTSSTLSAISNLQPWAIPQLISEMSSETSSPGGHIDDSHSEK
Sbjct:    1 MSASFSIDGILSTKKELSESIITSKSEESTKTHSNSLKHLLSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWRRQTSEEREAERQAASRYLLTLQNEINQSNNPSFNYTSSTLSAISNLQPWAIPQLISEMSSETSSPGGHIDDSHSEK 210

[Close]

BLAST of tlx vs. Planmine SMEST
Match: SMESG000021901.1 (SMESG000021901.1)

HSP 1 Score: 77.7962 bits (190), Expect = 1.261e-16
Identity = 35/62 (56.45%), Postives = 49/62 (79.03%), Query Frame = 2

Query:  356 NRTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            N    K+KK RT+F+ +QI ELE++F  +KYL+S+ER +LA  L++T++QVK WFQNRRTKW
Sbjct:  141 NSKQDKKKKSRTTFSGRQICELEKQFELKKYLSSAERAELASSLNVTETQVKIWFQNRRTKW 202

[Close]

BLAST of tlx vs. Planmine SMEST
Match: SMESG000030375.1 (SMESG000030375.1)

HSP 1 Score: 73.1738 bits (178), Expect = 7.284e-15
Identity = 41/96 (42.71%), Postives = 60/96 (62.50%), Query Frame = 2

Query:  263 LSTIFPPSLPRHWIEILRQDRYPRRVGHPYQNRTPPKRKKPR---TSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            L+ + P + P   ++++R   +   +G   Q+    K KKPR   T+F   Q+ ELER F RQKYL+  +R +LA  L ++D+QVKTW+QNRRTKW
Sbjct:   98 LNHVDPVNSPEKEMKMVRLKYF---LGSDSQSHDRSKSKKPRKARTAFTDLQLNELERNFDRQKYLSVQDRMELANRLRLSDTQVKTWYQNRRTKW 190

[Close]

BLAST of tlx vs. Planmine SMEST
Match: SMESG000022963.1 (SMESG000022963.1)

HSP 1 Score: 71.2478 bits (173), Expect = 1.264e-14
Identity = 43/103 (41.75%), Postives = 70/103 (67.96%), Query Frame = 2

Query:  377 KKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWXXXXXXXXXXXXXXXXXYLLTLQNEINQSNNPSF-NYTSSTLSAISNL 682
            +K RT+F  +Q+ ELE+ F + KYL+  +R +LA  L++TD+QVKTW+QNRRTKW+RQTS   +   + ++  +  L+  I+  NN  F N+ S+  +++SN+
Sbjct:   67 RKARTAFTEKQLCELEKSFDKHKYLSVQDRLELANYLELTDTQVKTWYQNRRTKWKRQTSTGVDLLTEGSN--VTDLRRSIHYPNNSKFWNWVSNNSASLSNI 167

[Close]

BLAST of tlx vs. Planmine SMEST
Match: SMESG000074896.1 (SMESG000074896.1)

HSP 1 Score: 72.0182 bits (175), Expect = 2.208e-14
Identity = 32/61 (52.46%), Postives = 45/61 (73.77%), Query Frame = 2

Query:  359 RTPPKRKKPRTSFNRQQIMELERRFHRQKYLASSERCDLAKDLDMTDSQVKTWFQNRRTKW 541
            ++  K +K RT+F   Q+ ELE+ F +QKYL+  +R +LA  L +TD+QVKTW+QNRRTKW
Sbjct:   84 QSGKKPRKARTAFTDHQLNELEKNFEQQKYLSVQDRMELAAKLRLTDTQVKTWYQNRRTKW 144

The following BLAST results are available for this feature:

BLAST of tlx vs. Ensembl Human
BLAST of tlx vs. Ensembl Celegans
BLAST of tlx vs. Ensembl Fly
BLAST of tlx vs. Ensembl Zebrafish
BLAST of tlx vs. Ensembl Xenopus
BLAST of tlx vs. Ensembl Mouse
BLAST of tlx vs. UniProt/SwissProt
BLAST of tlx vs. TrEMBL
BLAST of tlx vs. Ensembl Cavefish
BLAST of tlx vs. Ensembl Sea Lamprey
BLAST of tlx vs. Ensembl Yeast
BLAST of tlx vs. Ensembl Nematostella
BLAST of tlx vs. Ensembl Medaka
BLAST of tlx vs. Planmine SMEST

BLAST of tlx vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TLX3	5.835e-40	69.84	T cell leukemia homeobox 3 [Source:HGNC Symbol;Acc...	[more]
TLX2	6.124e-39	61.43	T cell leukemia homeobox 2 [Source:HGNC Symbol;Acc...	[more]
TLX1	6.325e-38	64.75	T cell leukemia homeobox 1 [Source:HGNC Symbol;Acc...	[more]
TLX1	1.736e-34	74.07	T cell leukemia homeobox 1 [Source:HGNC Symbol;Acc...	[more]
BARHL2	1.755e-15	59.38	BarH like homeobox 2 [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of tlx vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ceh-9	7.076e-19	56.92	Homeobox protein ceh-9 [Source:UniProtKB/Swiss-Pr...	[more]
cog-1	4.008e-16	54.39	COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2]	[more]
ceh-30	1.648e-15	50.72	Homeobox protein ceh-30 [Source:UniProtKB/Swiss-P...	[more]
ceh-30	1.648e-15	50.72	Homeobox protein ceh-30 [Source:UniProtKB/Swiss-P...	[more]
cog-1	1.897e-15	54.39	COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2]	[more]

BLAST of tlx vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
C15	4.697e-39	65.12	gene:FBgn0004863 transcript:FBtr0084111	[more]
B-H1	1.698e-15	57.89	gene:FBgn0011758 transcript:FBtr0074430	[more]
NK7.1	1.215e-14	57.89	gene:FBgn0024321 transcript:FBtr0306742	[more]
NK7.1	1.215e-14	57.89	gene:FBgn0024321 transcript:FBtr0347151	[more]
NK7.1	1.215e-14	57.89	gene:FBgn0024321 transcript:FBtr0082942	[more]

BLAST of tlx vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CABZ01067175.1	5.217e-41	68.75	T-cell leukemia homeobox protein 3-like [Source:NC...	[more]
tlx2	1.644e-40	63.57	T cell leukemia homeobox 2 [Source:ZFIN;Acc:ZDB-GE...	[more]
tlx3b	3.646e-40	63.45	T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-G...	[more]
tlx3b	3.646e-40	63.45	T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-G...	[more]
tlx2	1.024e-39	68.50	T cell leukemia homeobox 2 [Source:ZFIN;Acc:ZDB-GE...	[more]

BLAST of tlx vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
soga1	2.141e-41	68.75	suppressor of glucose, autophagy associated 1 [Sou...	[more]
ENSXETT00000011915.1	2.616e-40	66.43	T cell leukemia homeobox 1 [Source:NCBI gene;Acc:1...	[more]
jup	3.302e-39	68.25	junction plakoglobin [Source:Xenbase;Acc:XB-GENE-4...	[more]
BARHL2	1.089e-15	59.38	BarH like homeobox 2 [Source:NCBI gene;Acc:1004938...	[more]
BARHL2	1.149e-15	59.38	BarH like homeobox 2 [Source:NCBI gene;Acc:1004938...	[more]

BLAST of tlx vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tlx3	3.526e-40	69.84	T cell leukemia, homeobox 3 [Source:MGI Symbol;Acc...	[more]
Tlx2	2.293e-39	61.43	T cell leukemia, homeobox 2 [Source:MGI Symbol;Acc...	[more]
Tlx1	5.779e-38	64.75	T cell leukemia, homeobox 1 [Source:MGI Symbol;Acc...	[more]
Tlx2	3.566e-36	82.86	T cell leukemia, homeobox 2 [Source:MGI Symbol;Acc...	[more]
Barhl2	9.001e-16	59.65	BarH like homeobox 2 [Source:MGI Symbol;Acc:MGI:18...	[more]

BLAST of tlx vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O93367\|TLX3_CHICK	7.955e-40	69.84	T-cell leukemia homeobox protein 3 OS=Gallus gallu...	[more]
sp\|O55144\|TLX3_MOUSE	2.466e-39	69.84	T-cell leukemia homeobox protein 3 OS=Mus musculus...	[more]
sp\|O43711\|TLX3_HUMAN	2.802e-39	69.84	T-cell leukemia homeobox protein 3 OS=Homo sapiens...	[more]
sp\|Q61663\|TLX2_MOUSE	1.604e-38	61.43	T-cell leukemia homeobox protein 2 OS=Mus musculus...	[more]
sp\|O43763\|TLX2_HUMAN	2.941e-38	61.43	T-cell leukemia homeobox protein 2 OS=Homo sapiens...	[more]

BLAST of tlx vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0A1CQY5	2.077e-71	100.00	Tlx (Fragment) OS=Schmidtea mediterranea OX=79327 ...	[more]
K1RAP6	1.668e-41	68.61	T-cell leukemia homeobox protein 3 OS=Crassostrea ...	[more]
A0A1S3GYP0	7.828e-41	64.83	T-cell leukemia homeobox protein 3 isoform X1 OS=L...	[more]
A0A345F2S4	1.349e-40	63.16	Tlx homeodomain protein (Fragment) OS=Euperipatoid...	[more]
X5JAI5	1.782e-40	63.16	Clawless OS=Euperipatoides kanangrensis OX=488523 ...	[more]

BLAST of tlx vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000055288.1	1.582e-41	70.87	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
tlx2	9.165e-41	64.29	T cell leukemia homeobox 2 [Source:NCBI gene;Acc:1...	[more]
tlx3b	1.043e-40	64.49	T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-G...	[more]
tlx1	4.715e-40	65.94	T cell leukemia homeobox 1 [Source:NCBI gene;Acc:1...	[more]
HMX2	1.841e-16	60.71	H6 family homeobox 2 [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of tlx vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tlx1	1.085e-35	75.00	T cell leukemia homeobox 1 [Source:ZFIN;Acc:ZDB-GE...	[more]
barhl2	1.715e-16	56.14	BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050...	[more]
barhl2	1.775e-16	56.14	BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050...	[more]
ENSPMAT00000001141.1	8.362e-16	54.39	pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 ...	[more]
hhex	9.857e-16	53.85	pep scaffold:Pmarinus_7.0:GL476649:273574:289580:-...	[more]

BLAST of tlx vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of tlx vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO34127	8.491e-19	65.45	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
ANTH.HBXC.NV	3.930e-17	57.14	NK-like 20; Predicted protein [Source:UniProtKB/T...	[more]
NK-3	4.889e-17	56.45	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32495	1.334e-15	53.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48767	2.643e-15	54.39	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of tlx vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tlx1	1.252e-40	70.63	T cell leukemia homeobox 1 [Source:NCBI gene;Acc:1...	[more]
ENSORLT00000004940.2	3.923e-40	68.75	T cell leukemia homeobox 3 [Source:NCBI gene;Acc:1...	[more]
barhl2	1.001e-15	59.65	BarH like homeobox 2 [Source:NCBI gene;Acc:1011744...	[more]
ENSORLT00000038356.1	2.361e-15	57.89	barH-like 1 homeobox protein [Source:NCBI gene;Acc...	[more]
nkx6.1	5.212e-15	61.40	NK6 homeobox 1 [Source:NCBI gene;Acc:101156548]	[more]

BLAST of tlx vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000017206.1	3.929e-121	100.00	SMESG000017206.1	[more]
SMESG000021901.1	1.261e-16	56.45	SMESG000021901.1	[more]
SMESG000030375.1	7.284e-15	42.71	SMESG000030375.1	[more]
SMESG000022963.1	1.264e-14	41.75	SMESG000022963.1	[more]
SMESG000074896.1	2.208e-14	52.46	SMESG000074896.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30034115
GenBank	AIX99548.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30034115 ID=SMED30034115|Name=tlx|organism=Schmidtea mediterranea sexual|type=transcript|length=816bp
CCCGGGATGAAAATTATCAGCAATTATTGGCCAATCGAAACCGTTTCAAT
GTGCTTGTTCTTGATCCTGTCATTTGATTTGATCGCTTCTCTCGATTTAT
TATGAATTCCTTTTCTGGAATTCTTACACAATCCCAGCAAATATGTCAGC
ATCGTTTTCCATTGATGGAATATTGTCGACGAAAAAAGAGCTTTCCGAAT
CCATTATTACCTCGAAATCAGAAGAATCAACGAAGACTCATTCGAATTCT
TTGAAACATTTATTATCCACAATTTTCCCTCCTTCTCTTCCAAGGCATTG
GATAGAAATATTGCGACAGGATCGTTATCCCCGACGAGTTGGTCATCCAT
ATCAGAATAGAACCCCTCCAAAAAGAAAAAAGCCTCGAACATCCTTTAAT
CGGCAACAGATCATGGAACTTGAGAGACGGTTTCATCGTCAGAAGTATCT
CGCATCATCAGAACGATGCGATCTAGCGAAAGATCTCGATATGACAGACT
CTCAAGTGAAGACTTGGTTTCAAAACCGGAGAACAAAATGGAGGCGACAA
ACCAGCGAAGAAAGAGAAGCAGAAAGACAAGCAGCCAGTCGGTATTTATT
GACACTTCAAAACGAAATCAACCAATCTAACAATCCTTCTTTTAATTATA
CCAGCTCTACTCTTTCCGCCATATCCAACCTCCAACCTTGGGCAATACCA
CAACTCATATCCGAAATGTCTTCTGAAACGTCTTCTCCAGGGGGTCATAT
TGACGATTCTCATTCGGAGAAATGATAATAAATGATTTATTAACACAAAT
TGTCAATAATAAATGA

protein sequence of SMED30034115-orf-1

>SMED30034115-orf-1 ID=SMED30034115-orf-1|Name=SMED30034115-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=211bp
MSASFSIDGILSTKKELSESIITSKSEESTKTHSNSLKHLLSTIFPPSLP
RHWIEILRQDRYPRRVGHPYQNRTPPKRKKPRTSFNRQQIMELERRFHRQ
KYLASSERCDLAKDLDMTDSQVKTWFQNRRTKWRRQTSEEREAERQAASR
YLLTLQNEINQSNNPSFNYTSSTLSAISNLQPWAIPQLISEMSSETSSPG
GHIDDSHSEK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000030	midline
PLANA:0000043	dorsal ventral margin of the whole animal
PLANA:0000240	body wall musculature
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR042247	TLX1/2/3
IPR020479	Homeobox_metazoa
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR020479	Homeobox domain, metazoa	PRINTS	PR00024	HOMEOBOX	coord: 115..125 score: 46.74 coord: 125..134 score: 73.73 coord: 100..111 score: 34.88
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 78..140 e-value: 3.8E-24 score: 96.2
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 79..135 e-value: 9.4E-21 score: 73.4
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 76..136 score: 20.714
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 79..136 e-value: 5.12268E-19 score: 75.3576
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 62..154 e-value: 1.1E-29 score: 103.8
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 191..210
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 64..85
None	No IPR available	PANTHER	PTHR45921:SF6	C15	coord: 53..186
IPR042247	T-cell leukemia homeobox protein 1/2/3	PANTHER	PTHR45921	FAMILY NOT NAMED	coord: 53..186
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 111..134
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 67..136

Main menu

tlx

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Owlery

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