Transmembrane protein

Overview


Name	Transmembrane protein
Smed ID	SMED30034050
Length (bp)	1646

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Transmembrane protein (SMED30034050) t-SNE clustered cells

Violin plots show distribution of expression levels for Transmembrane protein (SMED30034050) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Transmembrane protein (SMED30034050) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Transmembrane protein (SMED30034050) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30034050

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30034050	SMESG000058746.1	PL04021A1B12	ncbi_smed_ests	PMID:23079596 Forsthoefel et al., 2012
epidermis	SMED30034050	SMESG000058746.1	PL04021A1B12	ncbi_smed_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30034050	SMESG000058746.1	PL04021A1B12	ncbi_smed_ests	PMID:23079596 Forsthoefel et al., 2012

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Transmembrane protein vs. Ensembl Human
Match: TMEM106A (transmembrane protein 106A [Source:HGNC Symbol;Acc:HGNC:28288])

HSP 1 Score: 62.003 bits (149), Expect = 2.915e-10
Identity = 43/112 (38.39%), Postives = 70/112 (62.50%), Query Frame = 3

Query:  180 CPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            CPTC+G+GKI ++ E + +ALIP  D+RL+PK   L V LAVLIC+V +  ++FFL PRS+ +     +    S  +   + + Y+NI+  +   +SN N+ PI V+ + ++
Sbjct:   11 CPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLN----SSTVAFDEADIYLNIT--NILNISNGNYYPIMVTQLTLE 116

[Close]

BLAST of Transmembrane protein vs. Ensembl Human
Match: TMEM106A (transmembrane protein 106A [Source:HGNC Symbol;Acc:HGNC:28288])

HSP 1 Score: 61.2326 bits (147), Expect = 5.973e-10
Identity = 43/114 (37.72%), Postives = 71/114 (62.28%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            + CPTC+G+GKI ++ E + +ALIP  D+RL+PK   L V LAVLIC+V +  ++FFL PRS+ +     +    S  +   + + Y+NI+  +   +SN N+ PI V+ + ++
Sbjct:   57 VTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLN----SSTVAFDEADIYLNIT--NILNISNGNYYPIMVTQLTLE 164

[Close]

BLAST of Transmembrane protein vs. Ensembl Human
Match: TMEM106A (transmembrane protein 106A [Source:HGNC Symbol;Acc:HGNC:28288])

HSP 1 Score: 61.2326 bits (147), Expect = 9.824e-10
Identity = 43/114 (37.72%), Postives = 71/114 (62.28%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            + CPTC+G+GKI ++ E + +ALIP  D+RL+PK   L V LAVLIC+V +  ++FFL PRS+ +     +    S  +   + + Y+NI+  +   +SN N+ PI V+ + ++
Sbjct:   57 VTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLN----SSTVAFDEADIYLNIT--NILNISNGNYYPIMVTQLTLE 164

[Close]

BLAST of Transmembrane protein vs. Ensembl Human
Match: TMEM106A (transmembrane protein 106A [Source:HGNC Symbol;Acc:HGNC:28288])

HSP 1 Score: 61.2326 bits (147), Expect = 9.824e-10
Identity = 43/114 (37.72%), Postives = 71/114 (62.28%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            + CPTC+G+GKI ++ E + +ALIP  D+RL+PK   L V LAVLIC+V +  ++FFL PRS+ +     +    S  +   + + Y+NI+  +   +SN N+ PI V+ + ++
Sbjct:   57 VTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLN----SSTVAFDEADIYLNIT--NILNISNGNYYPIMVTQLTLE 164

[Close]

BLAST of Transmembrane protein vs. Ensembl Human
Match: TMEM106B (transmembrane protein 106B [Source:HGNC Symbol;Acc:HGNC:22407])

HSP 1 Score: 57.3806 bits (137), Expect = 1.787e-8
Identity = 30/65 (46.15%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP+R  L V+ +V +C++ + L +FFL PRSI++
Sbjct:   59 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDV 123

[Close]

BLAST of Transmembrane protein vs. Ensembl Zebrafish
Match: tmem106ba (transmembrane protein 106Ba [Source:ZFIN;Acc:ZDB-GENE-040426-1336])

HSP 1 Score: 61.2326 bits (147), Expect = 5.688e-10
Identity = 55/190 (28.95%), Postives = 101/190 (53.16%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTM-NGVPYNVYKKDVDENVPM---KVDYKVKYNGIVTIQDQPEQV-SMCQQKPKYTHSIFVLYRYSSITMVWLWN 728
            + CPTC+G G+I ++ E + +ALIP +D+RL+P+R  L V ++V +C++ + L +FFL PR+IN+  +   +  + V         Y+NI+      ++N NF PI ++ +     + N V  N    +V   +P+   ++DY V      TI ++   +   C  +    H++ VL R  ++T V+  +
Sbjct:   47 ITCPTCQGTGRIPRNQENQLVALIPYSDQRLKPRRTTLYVSISVFLCLLLSGLAVFFLFPRTINV--SYAGVKSSYVTYDHNLHKVYLNIT--STLNITNNNFYPIQLANITAQVQLYNTVIGNSVANNVTTIIPLDMRQIDYTVP----TTIANEINYIYEYCTMQAIKVHNVVVLMRM-TVTAVYFGH 227

[Close]

BLAST of Transmembrane protein vs. Ensembl Zebrafish
Match: tmem106bb (transmembrane protein 106Bb [Source:NCBI gene;Acc:566699])

HSP 1 Score: 57.3806 bits (137), Expect = 1.039e-8
Identity = 30/65 (46.15%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP+R  L V+ +V++C++   L +FFL PRSI++
Sbjct:   55 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVILCLLLCTLAVFFLFPRSIDV 119

[Close]

BLAST of Transmembrane protein vs. Ensembl Zebrafish
Match: tmem106bb (transmembrane protein 106Bb [Source:NCBI gene;Acc:566699])

HSP 1 Score: 57.3806 bits (137), Expect = 1.107e-8
Identity = 30/65 (46.15%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP+R  L V+ +V++C++   L +FFL PRSI++
Sbjct:   55 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVILCLLLCTLAVFFLFPRSIDV 119

[Close]

BLAST of Transmembrane protein vs. Ensembl Zebrafish
Match: tmem106c (transmembrane protein 106C [Source:ZFIN;Acc:ZDB-GENE-061013-562])

HSP 1 Score: 54.6842 bits (130), Expect = 8.929e-8
Identity = 38/112 (33.93%), Postives = 65/112 (58.04%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVN 509
            + CPTC+G+G+I      E +ALIP +D+RL+P+R  L V+L+V++C++ + L+ FFL PR++ +     D    SV +   + N  + I+       +N NF  + V  V+
Sbjct:   57 ITCPTCQGSGRIPAGQLNELVALIPYSDQRLQPRRTKLYVVLSVILCLLASFLVAFFLFPRAVLV----VDDGIRSVTVHFDRNNSKVLINMTSSLNFTNSNFFTVWVDSVS 164

[Close]

BLAST of Transmembrane protein vs. Ensembl Zebrafish
Match: tmem106a (transmembrane protein 106A [Source:ZFIN;Acc:ZDB-GENE-030131-5129])

HSP 1 Score: 49.6766 bits (117), Expect = 2.980e-6
Identity = 38/112 (33.93%), Postives = 63/112 (56.25%), Query Frame = 3

Query:  180 CPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENP-YINISFQDFFELSNVNFLPITVSFVNV 512
            CPTC+G G+I +  E + +A+IP +D+RL+P    L V ++V +C++   L+LFFL PRS+       DM    +  + +   P  + I       L+N NF+ IT + ++V
Sbjct:   30 CPTCQGTGRIPRGQENQLVAVIPCSDQRLKPHHTSLYVCISVGLCLLICSLILFFLFPRSM-------DMSAVELQSSMVYFTPDSVKIVVTHQMNLTNQNFVSITANNLSV 134

[Close]

BLAST of Transmembrane protein vs. Ensembl Xenopus
Match: tmem106b (transmembrane protein 106B [Source:NCBI gene;Acc:549566])

HSP 1 Score: 53.5286 bits (127), Expect = 4.268e-7
Identity = 28/65 (43.08%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + C TC+G G+I +  E + +ALIP +D+RLRP+R  L V ++V++C++ + L +FFL PRS+++
Sbjct:   58 VTCATCQGTGRIPRGRENQLVALIPYSDQRLRPRRTKLYVTISVIVCLLLSCLAVFFLFPRSVDV 122

[Close]

BLAST of Transmembrane protein vs. Ensembl Xenopus
Match: tmem106b (transmembrane protein 106B [Source:NCBI gene;Acc:549566])

HSP 1 Score: 52.7582 bits (125), Expect = 4.873e-7
Identity = 28/65 (43.08%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + C TC+G G+I +  E + +ALIP +D+RLRP+R  L V ++V++C++ + L +FFL PRS+++
Sbjct:   58 VTCATCQGTGRIPRGRENQLVALIPYSDQRLRPRRTKLYVTISVIVCLLLSCLAVFFLFPRSVDV 122

[Close]

BLAST of Transmembrane protein vs. Ensembl Xenopus
Match: hapln1 (hyaluronan and proteoglycan link protein 1 [Source:Xenbase;Acc:XB-GENE-6037477])

HSP 1 Score: 52.373 bits (124), Expect = 7.220e-7
Identity = 36/108 (33.33%), Postives = 62/108 (57.41%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITV 497
            + CP+C+G G I  +   E +ALIP +D+RL+P+R  L V+L+V++C++   L++FFL PR++ I      M    V +    EN  + +      ++SN NF  ++ 
Sbjct:   52 ITCPSCQGTGCIPTEQVNELVALIPYSDQRLQPQRTKLYVLLSVILCLLICGLVVFFLFPRTVLIEDGGIKM----VKVWFDTENKVVILGMTSTLKISNSNFYSVSA 155

[Close]

BLAST of Transmembrane protein vs. Ensembl Xenopus
Match: hapln1 (hyaluronan and proteoglycan link protein 1 [Source:Xenbase;Acc:XB-GENE-6037477])

HSP 1 Score: 51.9878 bits (123), Expect = 1.039e-6
Identity = 36/108 (33.33%), Postives = 62/108 (57.41%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITV 497
            + CP+C+G G I  +   E +ALIP +D+RL+P+R  L V+L+V++C++   L++FFL PR++ I      M    V +    EN  + +      ++SN NF  ++ 
Sbjct:   52 ITCPSCQGTGCIPTEQVNELVALIPYSDQRLQPQRTKLYVLLSVILCLLICGLVVFFLFPRTVLIEDGGIKM----VKVWFDTENKVVILGMTSTLKISNSNFYSVSA 155

[Close]

BLAST of Transmembrane protein vs. Ensembl Mouse
Match: Tmem106a (transmembrane protein 106A [Source:MGI Symbol;Acc:MGI:1922056])

HSP 1 Score: 63.929 bits (154), Expect = 1.972e-11
Identity = 41/117 (35.04%), Postives = 70/117 (59.83%), Query Frame = 3

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIK-ENPYINISFQDFFELSNVNFLPITVS 500
            K+ ++  + CPTC+GNG+I ++ E + +ALIP  D+RL+P+R  L V L+V IC++   L +FFL PR I +        P  +  + +  E+ ++ ++  +   + N NF PITV+
Sbjct:   49 KAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVR-------PVGLNSSTVTFEDAHVQLNTTNVLNIFNSNFYPITVT 158

[Close]

BLAST of Transmembrane protein vs. Ensembl Mouse
Match: Tmem106a (transmembrane protein 106A [Source:MGI Symbol;Acc:MGI:1922056])

HSP 1 Score: 61.6178 bits (148), Expect = 9.206e-11
Identity = 40/115 (34.78%), Postives = 68/115 (59.13%), Query Frame = 3

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIK-ENPYINISFQDFFELSNVNFLPIT 494
            K+ ++  + CPTC+GNG+I ++ E + +ALIP  D+RL+P+R  L V L+V IC++   L +FFL PR I +        P  +  + +  E+ ++ ++  +   + N NF PIT
Sbjct:   49 KAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVR-------PVGLNSSTVTFEDAHVQLNTTNVLNIFNSNFYPIT 156

[Close]

BLAST of Transmembrane protein vs. Ensembl Mouse
Match: Tmem106a (transmembrane protein 106A [Source:MGI Symbol;Acc:MGI:1922056])

HSP 1 Score: 63.5438 bits (153), Expect = 9.473e-11
Identity = 42/121 (34.71%), Postives = 72/121 (59.50%), Query Frame = 3

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            K+ ++  + CPTC+GNG+I ++ E + +ALIP  D+RL+P+R  L V L+V IC++   L +FFL PR I +     +    S  +T   E+ ++ ++  +   + N NF PITV+ +  +
Sbjct:   49 KAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVRPVGLN----SSTVT--FEDAHVQLNTTNVLNIFNSNFYPITVTQLTAE 163

[Close]

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            K+ ++  + CPTC+GNG+I ++ E + +ALIP  D+RL+P+R  L V L+V IC++   L +FFL PR I +     +    S  +T   E+ ++ ++  +   + N NF PITV+ +  +
Sbjct:   49 KAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVRPVGLN----SSTVT--FEDAHVQLNTTNVLNIFNSNFYPITVTQLTAE 163

[Close]

BLAST of Transmembrane protein vs. Ensembl Mouse
Match: Tmem106b (transmembrane protein 106B [Source:MGI Symbol;Acc:MGI:1919150])

HSP 1 Score: 55.4546 bits (132), Expect = 1.651e-8
Identity = 30/65 (46.15%), Postives = 47/65 (72.31%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP+R  L V+ +V +C++ + L +FFL PRSI +
Sbjct:   60 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIEV 124

[Close]

BLAST of Transmembrane protein vs. UniProt/SwissProt
Match: sp|Q5BK83|T106A_RAT (Transmembrane protein 106A OS=Rattus norvegicus OX=10116 GN=Tmem106a PE=2 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 1.469e-11
Identity = 42/121 (34.71%), Postives = 73/121 (60.33%), Query Frame = 3

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            K+ +   + CPTC+GNG+I ++ E + +ALIP  D+RL+P+R  L V LAV IC++   L +FFL PR+I +H     +  ++V   E     ++ ++  +   ++N NF P+TV+ +  +
Sbjct:   49 KAASTSFVTCPTCQGNGEIPQELEKQLVALIPYGDQRLKPRRTKLSVFLAVTICLLIFSLTIFFLYPRNIVVHP--VGLNSSTVAFDET----HVQLNMTNVLNITNSNFYPVTVTQLTAE 163

[Close]

BLAST of Transmembrane protein vs. UniProt/SwissProt
Match: sp|Q5EA90|T106A_BOVIN (Transmembrane protein 106A OS=Bos taurus OX=9913 GN=TMEM106A PE=2 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 4.880e-11
Identity = 45/121 (37.19%), Postives = 76/121 (62.81%), Query Frame = 3

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            ++     + CPTC+G+G+I ++ E + +ALIP  D+RL+P+   L V LAV IC+V + L++FFL PR+I +     +   +S V T+ + N Y+NI+      +SN N+ PITV+ + ++
Sbjct:   49 RAAGAGFVTCPTCQGSGEIPRELEKQLVALIPYGDQRLKPRHTKLSVFLAVSICLVTSSLIIFFLFPRTIAVQPVGLN---SSTVATD-EANVYLNIT--SILNISNNNYCPITVTQLTIE 163

[Close]

BLAST of Transmembrane protein vs. UniProt/SwissProt
Match: sp|Q8VC04|T106A_MOUSE (Transmembrane protein 106A OS=Mus musculus OX=10090 GN=Tmem106a PE=1 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 6.627e-10
Identity = 42/121 (34.71%), Postives = 72/121 (59.50%), Query Frame = 3

Query:  153 KSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            K+ ++  + CPTC+GNG+I ++ E + +ALIP  D+RL+P+R  L V L+V IC++   L +FFL PR I +     +    S  +T   E+ ++ ++  +   + N NF PITV+ +  +
Sbjct:   49 KAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVRPVGLN----SSTVT--FEDAHVQLNTTNVLNIFNSNFYPITVTQLTAE 163

[Close]

BLAST of Transmembrane protein vs. UniProt/SwissProt
Match: sp|Q96A25|T106A_HUMAN (Transmembrane protein 106A OS=Homo sapiens OX=9606 GN=TMEM106A PE=1 SV=1)

HSP 1 Score: 61.2326 bits (147), Expect = 4.718e-9
Identity = 43/114 (37.72%), Postives = 71/114 (62.28%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVD 515
            + CPTC+G+GKI ++ E + +ALIP  D+RL+PK   L V LAVLIC+V +  ++FFL PRS+ +     +    S  +   + + Y+NI+  +   +SN N+ PI V+ + ++
Sbjct:   57 VTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLN----SSTVAFDEADIYLNIT--NILNISNGNYYPIMVTQLTLE 164

[Close]

BLAST of Transmembrane protein vs. UniProt/SwissProt
Match: sp|Q3ZC25|T106B_BOVIN (Transmembrane protein 106B OS=Bos taurus OX=9913 GN=TMEM106B PE=2 SV=1)

HSP 1 Score: 57.7658 bits (138), Expect = 7.619e-8
Identity = 30/65 (46.15%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP+R  L V+ +V +C++ + L +FFL PRSI++
Sbjct:   60 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDV 124

[Close]

BLAST of Transmembrane protein vs. TrEMBL
Match: A0A094ZIP3 (Transmembrane protein 106A OS=Schistosoma haematobium OX=6185 GN=MS3_02010 PE=4 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 1.797e-13
Identity = 58/184 (31.52%), Postives = 104/184 (56.52%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQP-EQVSMCQQKPKYTHSIFVLYRYS-SITMVW 719
            + CPTC G G + KDS AEY+ALIPL D+RLRP+R+ LK+  +V+IC +  +LLL FL PR+I++  +   +   S  I  +++N  I+++  +   +SN NF+P T++ + V      V       +  + +P++ +  +     +  + +  + + +C  K  Y H I+V + +  S T++W
Sbjct:   11 VACPTCSGAGYVRKDSRAEYVALIPLTDRRLRPRRICLKLFGSVVICSLVFILLLVFLFPRTISLRSSAYKLITIS-AIANMQDN-LIDLTVINQINVSNPNFVPTTITKIIVSPKYRSVDLQETVNNSIQMLPLRSETLLNVTTKLLFEHKHFDVIKLCLMKLPYFHDIYVTFTFHVSYTLLW 192

[Close]

BLAST of Transmembrane protein vs. TrEMBL
Match: A0A3Q0KRJ6 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 1.836e-13
Identity = 59/185 (31.89%), Postives = 104/185 (56.22%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQP-EQVSMCQQKPKYTHSIFVLYRYSSITMVWLW 725
            + CPTC G G + KDS AEY+ALIPL D+RLRP+R+ LK+  +V+IC +  +LLL FL PR+I++  +   +   S  I  +++N  I+++  +   +SN NF+P T++ ++V      V       +  + +P++ +  +     +  + +  + + +C  K  Y H I+V + +  IT   LW
Sbjct:   11 VACPTCSGAGYVRKDSRAEYVALIPLTDRRLRPRRICLKLFGSVMICSLVFILLLVFLFPRTISLRSSVYKLVTIS-AIANMQDN-LIDLTVINQINVSNPNFVPTTITKISVSPKYRSVDLQETVNNSIQMLPLRSETLLNVTTKLLFEHKHFDVIKLCLMKLPYFHDIYVTFIF-HITYTLLW 192

[Close]

BLAST of Transmembrane protein vs. TrEMBL
Match: A0A564YES6 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS4984 PE=4 SV=1)

HSP 1 Score: 80.8777 bits (198), Expect = 1.854e-13
Identity = 71/207 (34.30%), Postives = 114/207 (55.07%), Query Frame = 3

Query:  180 CPTCEGNGKISKDSEA----EYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQPEQV---SMCQQKPKYTHSIFVLYRYSSITMVWLWNLLNILEVCFEFLLNFFH 779
            CPTC G+G I  D+ A    EYIALIPL D+RLRP+R+ +K++L V++C+V + LLLFFL+ RS+ +   D  + P +V ITE   +  +N+S+     ++N NF+P+ V  V++    +       + ++DE VP +   ++  N  +   D    V    MCQ    Y + I++ +R S++ M       N L   FE +L+ F 
Sbjct:   26 CPTCRGSGVIEDDAGASNGSEYIALIPLTDQRLRPQRITIKILLTVMLCLVISGLLLFFLMLRSVELSSADHLLLPDNVNITESTVS--LNLSYP--INVTNWNFVPLHVESVDLMAFYHAYVLKQTEANLDEWVPARSTKELHVNQTLVFDDPIFSVYLPKMCQMNNTYYNQIYITFR-SNVKM-------NTLGQHFESVLDTFQ 220

[Close]

BLAST of Transmembrane protein vs. TrEMBL
Match: C1L802 (Transmembrane protein 106A OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 2.395e-13
Identity = 63/194 (32.47%), Postives = 105/194 (54.12%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVS---------FVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQPEQVSMCQQKPKYTHSIFVLYRYSSITMVWLWN 728
            +VCPTC G G + +DS AEY+ALIPL D+RLRP+R+ LK+  +V+IC +   LLL FL PR+I +  +   +   S  I  +++N  I+++  +   +SN NF+P TV+          V++  T+N    ++Y   +     + V  K+++          + + +C  K  Y H I+V + +  IT + LW 
Sbjct:   11 VVCPTCTGAGYVRRDSRAEYVALIPLTDRRLRPRRICLKLFGSVVICSLVFTLLLIFLFPRTIYLRSSVYKLITVS-AIANMQDN-VIDLTVINQINVSNPNFVPATVNKVIISPKYRSVDLQETVNN---SIYMLPLRSETLLNVSTKLRFE-----HKHFDVIKLCFMKLPYFHDIYVTFTF-HITYMLLWQ 193

[Close]

BLAST of Transmembrane protein vs. TrEMBL
Match: G4V5B2 (Putative transmembrane protein 106C (Endoplasmic reticulum membrane protein overexpressed in cancer) OS=Schistosoma mansoni OX=6183 GN=Smp_160410.2 PE=4 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 7.023e-13
Identity = 56/176 (31.82%), Postives = 100/176 (56.82%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQP-EQVSMCQQKPKYTHSIFVLYRY 698
            + CPTC G G + KDS AEY+ALIPL D+RLRP+R+ LK+  +V+IC +  +LLL FL PR+I++  +   +   S  I  +++N  I+++  +   +SN NF+P T++ ++V      V       +  + +P++ +  +     +  + +  + + +C  K  Y H I+V + Y
Sbjct:   11 VACPTCSGAGYVRKDSRAEYVALIPLTDRRLRPRRICLKLFGSVMICSLVFILLLVFLFPRTISLRSSVYKLVTIS-AIANMQDN-LIDLTVINQINVSNPNFVPTTITKISVSPKYRSVDLQETVNNSIQMLPLRSETLLNVTTKLLFEHKHFDVIKLCLMKLPYFHDIYVTFIY 184

[Close]

BLAST of Transmembrane protein vs. Ensembl Cavefish
Match: tmem106bb (transmembrane protein 106B [Source:NCBI gene;Acc:103043314])

HSP 1 Score: 56.9954 bits (136), Expect = 1.159e-8
Identity = 30/65 (46.15%), Postives = 48/65 (73.85%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP+R  L V  +V++C++ + L +FFL PRSI++
Sbjct:   55 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVTASVVVCLLLSGLAVFFLFPRSIDV 119

[Close]

BLAST of Transmembrane protein vs. Ensembl Cavefish
Match: tmem106ba (transmembrane protein 106B [Source:NCBI gene;Acc:103025712])

HSP 1 Score: 56.6102 bits (135), Expect = 1.441e-8
Identity = 30/65 (46.15%), Postives = 50/65 (76.92%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I ++ E + +ALIP +D+RLRP+R  L V ++VL+C++ + L +FFL PR+I++
Sbjct:   49 VTCPTCQGTGRIPREQENQLVALIPYSDQRLRPRRTKLYVSVSVLVCLLLSGLAVFFLFPRTIDV 113

[Close]

BLAST of Transmembrane protein vs. Ensembl Cavefish
Match: tmem106a (transmembrane protein 106A [Source:NCBI gene;Acc:103034000])

HSP 1 Score: 52.7582 bits (125), Expect = 1.615e-7
Identity = 27/66 (40.91%), Postives = 49/66 (74.24%), Query Frame = 3

Query:  177 VCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHK 374
            +CPTC+G G+I +  EA+ +A+IP +D+RL+P+   L V +++++C++   L+LFFL PRS+ + +
Sbjct:   29 LCPTCQGTGRIPRGEEAQLVAVIPCSDQRLKPRHTKLYVSISIILCLLTCSLILFFLFPRSVEVSQ 94

[Close]

BLAST of Transmembrane protein vs. Ensembl Cavefish
Match: tmem106a (transmembrane protein 106A [Source:NCBI gene;Acc:103034000])

HSP 1 Score: 53.1434 bits (126), Expect = 1.795e-7
Identity = 27/66 (40.91%), Postives = 49/66 (74.24%), Query Frame = 3

Query:  177 VCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHK 374
            +CPTC+G G+I +  EA+ +A+IP +D+RL+P+   L V +++++C++   L+LFFL PRS+ + +
Sbjct:   29 LCPTCQGTGRIPRGEEAQLVAVIPCSDQRLKPRHTKLYVSISIILCLLTCSLILFFLFPRSVEVSQ 94

[Close]

BLAST of Transmembrane protein vs. Ensembl Sea Lamprey
Match: tmem106bb (transmembrane protein 106Bb [Source:NCBI gene;Acc:566699])

HSP 1 Score: 56.9954 bits (136), Expect = 1.068e-9
Identity = 28/65 (43.08%), Postives = 50/65 (76.92%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I ++ E + +ALIP +D+RL+P+R  L V+L+V  C++ + L+++FL PRS+++
Sbjct:   68 VTCPTCQGTGRIPREQENQLVALIPYSDQRLKPRRTKLYVLLSVFSCLLVSGLIVYFLFPRSVDV 132

[Close]

BLAST of Transmembrane protein vs. Ensembl Nematostella
Match: EDO48936 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHY5])

HSP 1 Score: 61.2326 bits (147), Expect = 1.837e-10
Identity = 37/117 (31.62%), Postives = 68/117 (58.12%), Query Frame = 3

Query:  180 CPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKE-NPYINISFQDFFELSNVNFLPITVSFVNVDYTMN 527
            CPTC G+G+++ + E + +ALIP+ D+RL+P+R +L +++A+L+C     + +  L PR +      T   P ++ I +     P+I I  Q+  E+ N NF  +++S +N   T +
Sbjct:   53 CPTCGGSGRLTSEQENDLVALIPVRDRRLKPRRTVLYLMIAILLCSTLASVTIALLFPRDVTFTLLGT--IPVNITIKQSNATTPFIVI--QNTLEVKNPNFFEVSLSALNQQVTWD 165

[Close]

BLAST of Transmembrane protein vs. Ensembl Medaka
Match: tmem106a (transmembrane protein 106A [Source:NCBI gene;Acc:101174171])

HSP 1 Score: 58.5362 bits (140), Expect = 2.580e-9
Identity = 42/118 (35.59%), Postives = 70/118 (59.32%), Query Frame = 3

Query:  180 CPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGV 533
            CPTC G G+I +  E + +A+IP ND RL+P+   L V LA+++C+    L+LFFL PRS+ +    T +   SV++    +N  I++   +  ++SN N++P+ V    V + M G+
Sbjct:   40 CPTCRGTGRIPRGQEEQLVAVIPCNDVRLKPRHTKLYVFLAMVLCLFVCCLILFFLFPRSVTL----TPVSVQSVMVYFTPDN--ISMDVTNLIKISNENYVPVQV----VTFNMQGL 147

[Close]

Query:  180 CPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGV 533
            CPTC G G+I +  E + +A+IP ND RL+P+   L V LA+++C+    L+LFFL PRS+ +    T +   SV++    +N  I++   +  ++SN N++P+ V    V + M G+
Sbjct:   40 CPTCRGTGRIPRGQEEQLVAVIPCNDVRLKPRHTKLYVFLAMVLCLFVCCLILFFLFPRSVTL----TPVSVQSVMVYFTPDN--ISMDVTNLIKISNENYVPVQV----VTFNMQGL 147

[Close]

Query:  180 CPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGV 533
            CPTC G G+I +  E + +A+IP ND RL+P+   L V LA+++C+    L+LFFL PRS+ +    T +   SV++    +N  I++   +  ++SN N++P+ V    V + M G+
Sbjct:   40 CPTCRGTGRIPRGQEEQLVAVIPCNDVRLKPRHTKLYVFLAMVLCLFVCCLILFFLFPRSVTL----TPVSVQSVMVYFTPDN--ISMDVTNLIKISNENYVPVQV----VTFNMQGL 147

[Close]

BLAST of Transmembrane protein vs. Ensembl Medaka
Match: tmem106ba (transmembrane protein 106B [Source:NCBI gene;Acc:101159132])

HSP 1 Score: 56.225 bits (134), Expect = 3.364e-8
Identity = 30/65 (46.15%), Postives = 47/65 (72.31%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINI 368
            + CPTC+G G+I +  E + +ALIP +D+RLRP R  L V ++V +C++ + L +FFL PRSI++
Sbjct:  116 VTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPSRTKLYVTISVTLCLLLSGLAVFFLFPRSIDV 180

[Close]

BLAST of Transmembrane protein vs. Ensembl Medaka
Match: tmem106c (transmembrane protein 106C [Source:NCBI gene;Acc:101169451])

HSP 1 Score: 51.2174 bits (121), Expect = 9.798e-7
Identity = 39/112 (34.82%), Postives = 65/112 (58.04%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVN 509
            + CPTC+G G+I  +   E +ALIP +D+RL+P+R  L V L+VL+C++ + L+ FFL PRS+ +   D  +   +V    + +   +N++       SN NF  + V  V+
Sbjct:   55 ITCPTCQGTGRIPSEQVNELVALIPYSDQRLQPQRTKLYVGLSVLLCLLVSSLVAFFLFPRSVVVE--DAGLRSVTVRFDHLSKKVLMNMT--STLNFSNPNFFSVLVQSVS 162

[Close]

BLAST of Transmembrane protein vs. Planmine SMEST
Match: SMESG000058746.1 (SMESG000058746.1)

HSP 1 Score: 381.719 bits (979), Expect = 5.575e-131
Identity = 214/248 (86.29%), Postives = 222/248 (89.52%), Query Frame = 3

Query:   81 MQRWFTKDEILCKNVTINTDLETVKSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQPEQVSMCQQKPKYTHSIFVLYRYSSITMVWLWNLLNILEVCFEFLLNFFHN--IISIALKTNHCV 818
            MQRWFTKDEILCKNVTINTDLETVKSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAVLICIVFTVLLLFFLLPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQPEQVSMCQQKPKYTHSIFVLYR   I M +        ++ F+ L +  H   ++S    TNH +
Sbjct:    1 MQRWFTKDEILCKNVTINTDLETVKSETNKILVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAVLICIVFTVLLLFFLLPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQPEQVSMCQQKPKYTHSIFVLYR---IQMHY--------QILFQTLESLTHGGFLMSCEPTTNHSI 237

[Close]

BLAST of Transmembrane protein vs. Planmine SMEST
Match: SMESG000046135.1 (SMESG000046135.1)

HSP 1 Score: 73.9442 bits (180), Expect = 2.572e-15
Identity = 46/144 (31.94%), Postives = 84/144 (58.33%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMKVDYKVKYN 605
            + CPTC G   ISK S   Y+ALIP  D+RL+P R+ +KV +AV I +  +  +++FL+ RSI++  N+ ++ P  +V   +  N  + + F+    ++N N+ P  +S +N   T++G+   ++ + V E + M+   +V +N
Sbjct:   12 ITCPTCNGKKYISKGSNPVYVALIPATDERLKPPRIWIKVSIAVAITLCISASIVYFLITRSISLSSNNENIVP-YIVKVNLNANT-LQLFFKKSLNITNNNYFPFYLSRINSYATVDGISRLIFNESVTETIKMRSTKEVNFN 153

[Close]

BLAST of Transmembrane protein vs. Planmine SMEST
Match: SMESG000046135.1 (SMESG000046135.1)

HSP 1 Score: 71.2478 bits (173), Expect = 2.341e-14
Identity = 44/136 (32.35%), Postives = 80/136 (58.82%), Query Frame = 3

Query:  174 LVCPTCEGNGKISKDSEAEYIALIPLNDKRLRPKRVMLKVILAXXXXXXXXXXXXXXXXPRSINIHKNDTDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNGVPYNVYKKDVDENVPMK 581
            + CPTC G   ISK S   Y+ALIP  D+RL+P R+ +KV +AV I +  +  +++FL+ RSI++  N+ ++ P  +V   +  N  + + F+    ++N N+ P  +S +N   T++G+   ++ + V E + M+
Sbjct:   12 ITCPTCNGKKYISKGSNPVYVALIPATDERLKPPRIWIKVSIAVAITLCISASIVYFLITRSISLSSNNENIVPY-IVKVNLNANT-LQLFFKKSLNITNNNYFPFYLSRINSYATVDGISRLIFNESVTETIKMR 145

The following BLAST results are available for this feature:

BLAST of Transmembrane protein vs. Ensembl Human
BLAST of Transmembrane protein vs. Ensembl Celegans
BLAST of Transmembrane protein vs. Ensembl Fly
BLAST of Transmembrane protein vs. Ensembl Zebrafish
BLAST of Transmembrane protein vs. Ensembl Xenopus
BLAST of Transmembrane protein vs. Ensembl Mouse
BLAST of Transmembrane protein vs. UniProt/SwissProt
BLAST of Transmembrane protein vs. TrEMBL
BLAST of Transmembrane protein vs. Ensembl Cavefish
BLAST of Transmembrane protein vs. Ensembl Sea Lamprey
BLAST of Transmembrane protein vs. Ensembl Yeast
BLAST of Transmembrane protein vs. Ensembl Nematostella
BLAST of Transmembrane protein vs. Ensembl Medaka
BLAST of Transmembrane protein vs. Planmine SMEST

BLAST of Transmembrane protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TMEM106A	2.915e-10	38.39	transmembrane protein 106A [Source:HGNC Symbol;Acc...	[more]
TMEM106A	5.973e-10	37.72	transmembrane protein 106A [Source:HGNC Symbol;Acc...	[more]
TMEM106A	9.824e-10	37.72	transmembrane protein 106A [Source:HGNC Symbol;Acc...	[more]
TMEM106A	9.824e-10	37.72	transmembrane protein 106A [Source:HGNC Symbol;Acc...	[more]
TMEM106B	1.787e-8	46.15	transmembrane protein 106B [Source:HGNC Symbol;Acc...	[more]

BLAST of Transmembrane protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Transmembrane protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Transmembrane protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tmem106ba	5.688e-10	28.95	transmembrane protein 106Ba [Source:ZFIN;Acc:ZDB-G...	[more]
tmem106bb	1.039e-8	46.15	transmembrane protein 106Bb [Source:NCBI gene;Acc:...	[more]
tmem106bb	1.107e-8	46.15	transmembrane protein 106Bb [Source:NCBI gene;Acc:...	[more]
tmem106c	8.929e-8	33.93	transmembrane protein 106C [Source:ZFIN;Acc:ZDB-GE...	[more]
tmem106a	2.980e-6	33.93	transmembrane protein 106A [Source:ZFIN;Acc:ZDB-GE...	[more]

BLAST of Transmembrane protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
tmem106b	4.268e-7	43.08	transmembrane protein 106B [Source:NCBI gene;Acc:5...	[more]
tmem106b	4.873e-7	43.08	transmembrane protein 106B [Source:NCBI gene;Acc:5...	[more]
hapln1	7.220e-7	33.33	hyaluronan and proteoglycan link protein 1 [Source...	[more]
hapln1	1.039e-6	33.33	hyaluronan and proteoglycan link protein 1 [Source...	[more]

BLAST of Transmembrane protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tmem106a	1.972e-11	35.04	transmembrane protein 106A [Source:MGI Symbol;Acc:...	[more]
Tmem106a	9.206e-11	34.78	transmembrane protein 106A [Source:MGI Symbol;Acc:...	[more]
Tmem106a	9.473e-11	34.71	transmembrane protein 106A [Source:MGI Symbol;Acc:...	[more]
Tmem106a	9.473e-11	34.71	transmembrane protein 106A [Source:MGI Symbol;Acc:...	[more]
Tmem106b	1.651e-8	46.15	transmembrane protein 106B [Source:MGI Symbol;Acc:...	[more]

BLAST of Transmembrane protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5BK83\|T106A_RAT	1.469e-11	34.71	Transmembrane protein 106A OS=Rattus norvegicus OX...	[more]
sp\|Q5EA90\|T106A_BOVIN	4.880e-11	37.19	Transmembrane protein 106A OS=Bos taurus OX=9913 G...	[more]
sp\|Q8VC04\|T106A_MOUSE	6.627e-10	34.71	Transmembrane protein 106A OS=Mus musculus OX=1009...	[more]
sp\|Q96A25\|T106A_HUMAN	4.718e-9	37.72	Transmembrane protein 106A OS=Homo sapiens OX=9606...	[more]
sp\|Q3ZC25\|T106B_BOVIN	7.619e-8	46.15	Transmembrane protein 106B OS=Bos taurus OX=9913 G...	[more]

BLAST of Transmembrane protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A094ZIP3	1.797e-13	31.52	Transmembrane protein 106A OS=Schistosoma haematob...	[more]
A0A3Q0KRJ6	1.836e-13	31.89	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
A0A564YES6	1.854e-13	34.30	Uncharacterized protein OS=Hymenolepis diminuta OX...	[more]
C1L802	2.395e-13	32.47	Transmembrane protein 106A OS=Schistosoma japonicu...	[more]
G4V5B2	7.023e-13	31.82	Putative transmembrane protein 106C (Endoplasmic r...	[more]

BLAST of Transmembrane protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
tmem106bb	1.159e-8	46.15	transmembrane protein 106B [Source:NCBI gene;Acc:1...	[more]
tmem106ba	1.441e-8	46.15	transmembrane protein 106B [Source:NCBI gene;Acc:1...	[more]
tmem106a	1.615e-7	40.91	transmembrane protein 106A [Source:NCBI gene;Acc:1...	[more]
tmem106a	1.795e-7	40.91	transmembrane protein 106A [Source:NCBI gene;Acc:1...	[more]

BLAST of Transmembrane protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
tmem106bb	1.068e-9	43.08	transmembrane protein 106Bb [Source:NCBI gene;Acc:...	[more]

BLAST of Transmembrane protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Transmembrane protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO48936	1.837e-10	31.62	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Transmembrane protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tmem106a	2.580e-9	35.59	transmembrane protein 106A [Source:NCBI gene;Acc:1...	[more]
tmem106a	2.580e-9	35.59	transmembrane protein 106A [Source:NCBI gene;Acc:1...	[more]
tmem106a	2.580e-9	35.59	transmembrane protein 106A [Source:NCBI gene;Acc:1...	[more]
tmem106ba	3.364e-8	46.15	transmembrane protein 106B [Source:NCBI gene;Acc:1...	[more]
tmem106c	9.798e-7	34.82	transmembrane protein 106C [Source:NCBI gene;Acc:1...	[more]

BLAST of Transmembrane protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000058746.1	5.575e-131	86.29	SMESG000058746.1	[more]
SMESG000046135.1	2.572e-15	31.94	SMESG000046135.1	[more]
SMESG000046135.1	2.341e-14	32.35	SMESG000046135.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30034050 ID=SMED30034050|Name=Transmembrane protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1646bp
CTTTTATTTTGGCGTTGAAGTAATTTTTTCGAGGTCAAATGATTTGTTTT
TATATTTAGTGAGTACTGATACTTTTTAACATGCAAAGATGGTTTACTAA
AGATGAAATTCTTTGTAAGAATGTCACTATAAACACAGATTTAGAAACTG
TGAAAAGTGAAACCAACAAAATATTAGTGTGTCCAACTTGTGAAGGAAAC
GGTAAAATTTCAAAAGATTCAGAAGCTGAATATATTGCTTTAATTCCACT
AAATGACAAACGACTTAGACCTAAGCGTGTGATGTTGAAAGTCATATTGG
CCGTTCTAATATGCATTGTTTTTACAGTATTACTATTATTTTTTCTTCTT
CCACGTTCAATAAATATTCATAAAAATGACACCGATATGTGTCCTACAAG
TGTTGTTATTACAGAAATAAAAGAAAACCCATATATTAATATTTCCTTTC
AAGATTTCTTCGAACTGAGTAACGTTAACTTTCTTCCCATAACAGTTTCT
TTTGTCAATGTAGACTACACGATGAATGGAGTTCCTTACAATGTCTATAA
AAAAGATGTTGATGAAAATGTTCCAATGAAAGTTGATTATAAAGTGAAAT
ATAATGGAATTGTTACAATTCAAGATCAGCCTGAACAAGTATCAATGTGT
CAGCAAAAACCGAAATACACTCATTCTATATTTGTGTTGTATAGATATTC
TTCCATTACCATGGTATGGCTTTGGAATCTCTTGAATATTTTGGAGGTTT
GCTTTGAATTTCTTTTGAATTTCTTTCATAATATAATTTCCATTGCTCTA
AAAACAAATCATTGTGTATTTTATCAAAATCCAAAGTATTTTTGGAACTC
AAAGAGAGTATTTAGTTAGGCCTAAAATGGATCAAACAAATCCCTATCTG
ATGTCCTTAACGCTGCTTCATCAAGGTACACCATCCAAGCTACGACTAGA
AAGAAAAATTAAAAATCACGTATCTGCTCGTACATCTTCATAACAATGTG
CAATAATGATCCAACAGCTTAAGACAATTTGATATTTAATGTTGACAATA
TAAACCATTTAGCTAATCAATAAAATTTGTCCTGTTACTTAAATTTTACT
TAATTTTACTCATTTTGTGTTTAATTAAAATTATTTATCTTTCGATATCT
ATTATCAGGACCGTAATTAAGATAAGTAGAAATTTTTTTAGTAGATCCTT
AATTTAGTGGTGCATCAGAATATTAGCAGTCATGGCGGGTAAATAGTAGT
AGTGCCTATCAAATCGGAAGCTTCTTGAGATATACCTAAGAGATTTTCTT
TAGGTACCCATCAGACGAAAAAGAAAAGAAAAGACATTAAATATTTTAGA
AAGCTTTACATCAACACTAATAATCAGAAGTGAACGTGGGTCTTTTGTTT
AATAATGCAATCTAAATTAATTCTATTGTTGGGAAAATATATTTTTCCAT
AATATTTTTTAACAGTTACGAAGATAATTACCGGATAAAGTAAAATATTA
CAGTTTCACAATATTTTGTGTGAATCTTTATATGTATATACGTGTATGTG
ATTGAATGCTTTTGTTGAGCTCGATTATTATAGGTGGTTTGACTGAAAAT
TCTCTCAGTTTATATGCTAGATTTAAACTTAATGACGCCTAGATCG

protein sequence of SMED30034050-orf-1

>SMED30034050-orf-1 ID=SMED30034050-orf-1|Name=SMED30034050-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=263bp
MQRWFTKDEILCKNVTINTDLETVKSETNKILVCPTCEGNGKISKDSEAE
YIALIPLNDKRLRPKRVMLKVILAVLICIVFTVLLLFFLLPRSINIHKND
TDMCPTSVVITEIKENPYINISFQDFFELSNVNFLPITVSFVNVDYTMNG
VPYNVYKKDVDENVPMKVDYKVKYNGIVTIQDQPEQVSMCQQKPKYTHSI
FVLYRYSSITMVWLWNLLNILEVCFEFLLNFFHNIISIALKTNHCVFYQN
PKYFWNSKRVFS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte

Vocabulary: **INTERPRO**
Term	Definition
IPR009790	DUF1356_TMEM106

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

Main menu

Transmembrane protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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