PWWP domain-containing protein 2A

Overview


Name	PWWP domain-containing protein 2A
Smed ID	SMED30033915
Length (bp)	1991

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of PWWP domain-containing protein 2A (SMED30033915) t-SNE clustered cells

Violin plots show distribution of expression levels for PWWP domain-containing protein 2A (SMED30033915) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of PWWP domain-containing protein 2A (SMED30033915) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for PWWP domain-containing protein 2A (SMED30033915) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033915

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30033915	SMESG000031464.1	dd_Smed_v4_7768_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30033915	SMESG000031464.1	dd_Smed_v4_7768_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30033915	SMESG000031464.1	dd_Smed_v4_7768_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Human
Match: PWWP2A (PWWP domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29406])

HSP 1 Score: 58.151 bits (139), Expect = 4.404e-8
Identity = 34/91 (37.36%), Postives = 48/91 (52.75%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  RI+W G    SFL L  L  F E+F+ +++ K K   Y+ AI  A K
Sbjct:  650 GRTICVGDIVWAKIYGFPWWPARILTI--TVSRKDNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGL-YRKAITEAAK 737

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Human
Match: PWWP2B (PWWP domain containing 2B [Source:HGNC Symbol;Acc:HGNC:25150])

HSP 1 Score: 54.6842 bits (130), Expect = 4.736e-7
Identity = 29/89 (32.58%), Postives = 44/89 (49.44%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 1308
            G   ++ +IVW KI G+P+WPA +   D     K  G    +  +++W G    SFL +  L  F E FK++++ K K    K   E A
Sbjct:  485 GRTVAVGDIVWGKIHGFPWWPARV--LDISLGQKEDGEPSWREAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAA 571

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Zebrafish
Match: CU855895.3 (pep chromosome:GRCz11:21:30025031:30030644:-1 gene:ENSDARG00000114922.1 transcript:ENSDART00000190810.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CU855895.3)

HSP 1 Score: 54.299 bits (129), Expect = 6.624e-8
Identity = 32/91 (35.16%), Postives = 47/91 (51.65%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  R++W G    SFL +  L  F E+F+ ++  K K   Y+ AI  A K
Sbjct:   89 GRTICVGDIVWAKILGFPWWPARILAI--TVSRKDNGLLVRQEARVSWFGSPTTSFLAITQLAPFLENFQSRFDKKRKGL-YRKAITEAAK 176

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Zebrafish
Match: pwwp2b (PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GENE-110930-2])

HSP 1 Score: 50.0618 bits (118), Expect = 8.140e-6
Identity = 30/97 (30.93%), Postives = 46/97 (47.42%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDN-------VSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELN 1323
            G   ++ ++VW KI G+P+WPA I S          V A   + K   ++W G    S L +  L  F E F+ +++ K K   Y+ AI  A K + 
Sbjct:  490 GHAVTVGDVVWGKIHGFPWWPARILSISGTRREDGEVDAPWPEAK---VSWFGSPTTSELSVAKLSPFREFFRSRFNRKKKGM-YRRAIMEAAKAVG 582

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Xenopus
Match: PWWP2A (PWWP domain containing 2A [Source:NCBI gene;Acc:100145656])

HSP 1 Score: 59.6918 bits (143), Expect = 1.319e-8
Identity = 34/91 (37.36%), Postives = 48/91 (52.75%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  RI+W G    SFL L  L  F E+F+ +++ K K   Y+ AI  A K
Sbjct:  682 GRTICVGDIVWAKIYGFPWWPARILAI--TVSRKDTGLLVRQEARISWFGSPTTSFLALSQLTPFLENFQSRFNKKRKGL-YRKAITEAAK 769

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Mouse
Match: Pwwp2a (PWWP domain containing 2A [Source:MGI Symbol;Acc:MGI:1918052])

HSP 1 Score: 55.4546 bits (132), Expect = 1.518e-7
Identity = 32/92 (34.78%), Postives = 48/92 (52.17%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSF-----DNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +      DN   ++ +    RI+W      S L L  L  F E+F+++++ K K   Y+ AI  A K
Sbjct:  350 GRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLARQEA---RISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGL-YRRAITEAAK 437

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Mouse
Match: Pwwp2b (PWWP domain containing 2B [Source:MGI Symbol;Acc:MGI:2142008])

HSP 1 Score: 55.0694 bits (131), Expect = 2.448e-7
Identity = 29/89 (32.58%), Postives = 44/89 (49.44%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 1308
            G   ++ +IVW KI G+P+WPA +   D     K  G    +  +++W G    SFL +  L  F E FK++++ K K    K   E A
Sbjct:  495 GRTVAVGDIVWGKIHGFPWWPARV--LDISLGQKEDGEPSWQEAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAA 581

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Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 1308
            G   ++ +IVW KI G+P+WPA +   D     K  G    +  +++W G    SFL +  L  F E FK++++ K K    K   E A
Sbjct:  495 GRTVAVGDIVWGKIHGFPWWPARV--LDISLGQKEDGEPSWQEAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAA 581

[Close]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Mouse
Match: Pwwp2a (PWWP domain containing 2A [Source:MGI Symbol;Acc:MGI:1918052])

HSP 1 Score: 54.6842 bits (130), Expect = 3.327e-7
Identity = 32/92 (34.78%), Postives = 48/92 (52.17%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSF-----DNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +      DN   ++ +    RI+W      S L L  L  F E+F+++++ K K   Y+ AI  A K
Sbjct:  625 GRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLARQE---ARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGL-YRRAITEAAK 712

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BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
Match: sp|F7AQ22|PWP2A_XENTR (PWWP domain-containing protein 2A OS=Xenopus tropicalis OX=8364 GN=pwwp2a PE=2 SV=2)

HSP 1 Score: 59.6918 bits (143), Expect = 6.979e-8
Identity = 34/91 (37.36%), Postives = 48/91 (52.75%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  RI+W G    SFL L  L  F E+F+ +++ K K   Y+ AI  A K
Sbjct:  679 GRTICVGDIVWAKIYGFPWWPARILAI--TVSRKDTGLLVRQEARISWFGSPTTSFLALSQLTPFLENFQSRFNKKRKGL-YRKAITEAAK 766

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BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
Match: sp|A0A1L8GR68|PWP2A_XENLA (PWWP domain-containing protein 2A OS=Xenopus laevis OX=8355 GN=pwwp2a PE=3 SV=2)

HSP 1 Score: 59.3066 bits (142), Expect = 1.063e-7
Identity = 34/91 (37.36%), Postives = 48/91 (52.75%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  RI+W G    SFL L  L  F E+F+ +++ K K   Y+ AI  A K
Sbjct:  679 GRTICVGDIVWAKIYGFPWWPARILAI--TISRKDNGLLIRQEARISWFGSPTTSFLALSQLAPFLENFQSRFNKKRKGL-YRKAITEAAK 766

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BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
Match: sp|Q96N64|PWP2A_HUMAN (PWWP domain-containing protein 2A OS=Homo sapiens OX=9606 GN=PWWP2A PE=1 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 2.115e-7
Identity = 34/91 (37.36%), Postives = 48/91 (52.75%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  RI+W G    SFL L  L  F E+F+ +++ K K   Y+ AI  A K
Sbjct:  650 GRTICVGDIVWAKIYGFPWWPARILTI--TVSRKDNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGL-YRKAITEAAK 737

[Close]

BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
Match: sp|Q6NUJ5|PWP2B_HUMAN (PWWP domain-containing protein 2B OS=Homo sapiens OX=9606 GN=PWWP2B PE=1 SV=3)

HSP 1 Score: 54.6842 bits (130), Expect = 2.274e-6
Identity = 29/89 (32.58%), Postives = 44/89 (49.44%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 1308
            G   ++ +IVW KI G+P+WPA +   D     K  G    +  +++W G    SFL +  L  F E FK++++ K K    K   E A
Sbjct:  485 GRTVAVGDIVWGKIHGFPWWPARV--LDISLGQKEDGEPSWREAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAA 571

[Close]

BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
Match: sp|Q69Z61|PWP2A_MOUSE (PWWP domain-containing protein 2A OS=Mus musculus OX=10090 GN=Pwwp2a PE=2 SV=2)

HSP 1 Score: 54.6842 bits (130), Expect = 2.327e-6
Identity = 32/92 (34.78%), Postives = 48/92 (52.17%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSF-----DNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +      DN   ++ +    RI+W      S L L  L  F E+F+++++ K K   Y+ AI  A K
Sbjct:  625 GRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLARQE---ARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGL-YRRAITEAAK 712

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BLAST of PWWP domain-containing protein 2A vs. TrEMBL
Match: J3JYI3 (PWWP domain-containing protein OS=Dendroctonus ponderosae OX=77166 PE=2 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 4.424e-9
Identity = 35/105 (33.33%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSP 1368
            G +  + ++VW KI G+P+WP  I +  N +   SQG +  + W G +  S +    L HF ++FK++Y+ K K   YK AI+ A  E   N D+ + +    SP
Sbjct:  109 GVRLLVGDVVWGKIHGFPWWPGKILTITNCN---SQGPQAHVTWYGSSTSSLMQCDQLSHFLDNFKVRYNKK-KKGPYKEAIKQATTEARENADNRVRQPLGNSP 209

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BLAST of PWWP domain-containing protein 2A vs. TrEMBL
Match: S4R8P7 (PWWP domain-containing protein OS=Petromyzon marinus OX=7757 PE=4 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 6.252e-9
Identity = 32/92 (34.78%), Postives = 52/92 (56.52%), Query Frame = 1

Query: 1051 KGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            +G    + +IVWAK+ G P+WPA ++S  +VS  +  G    +  ++ W G    SFLPL   + F E+F+ +YS + KS  Y+ A+  A +
Sbjct:   20 QGKVVCVGDIVWAKLHGCPWWPAQVRSV-SVSVQEESGLVLSQEAKMAWFGSTTTSFLPLSQAVPFMENFEARYSRRKKSNGYRRAVSEAAE 110

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BLAST of PWWP domain-containing protein 2A vs. TrEMBL
Match: A0A3P7NLX8 (PWWP domain-containing protein (Fragment) OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS6140 PE=4 SV=1)

HSP 1 Score: 70.4774 bits (171), Expect = 8.408e-9
Identity = 34/96 (35.42%), Postives = 51/96 (53.12%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA-----CKELNL 1326
            G+ F + +IVW K+ G+PFWPA I S   ++  +S G  C + W  W+Q S++    L  F EH+  K   + K   YK A++ A     C+E  L
Sbjct:  447 GSVFRLGDIVWCKLSGWPFWPARITS---IAKEESTGTAC-VRWFAWDQVSYMACDKLWPFLEHYDKKLDRRKKRGAYKQAVDQALEAARCREQEL 538

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BLAST of PWWP domain-containing protein 2A vs. TrEMBL
Match: N6TTU4 (PWWP domain-containing protein (Fragment) OS=Dendroctonus ponderosae OX=77166 GN=109542814 PE=4 SV=1)

HSP 1 Score: 70.0922 bits (170), Expect = 1.230e-8
Identity = 35/105 (33.33%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSP 1368
            G +  + ++VW KI G+P+WP  I +  N +   SQG +  + W G +  S +    L HF ++FK++Y+ K K   YK AI+ A  E   N D+ + +    SP
Sbjct:  512 GVRLLVGDVVWGKIHGFPWWPGKILTITNCN---SQGPQAHVTWYGSSTSSLMQCDQLSHFLDNFKVRYNKK-KKGPYKEAIKQATTEARENADNRVRQPLGNSP 612

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BLAST of PWWP domain-containing protein 2A vs. TrEMBL
Match: U4U3J2 (PWWP domain-containing protein OS=Dendroctonus ponderosae OX=77166 GN=D910_04281 PE=4 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 1.404e-8
Identity = 35/105 (33.33%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSP 1368
            G +  + ++VW KI G+P+WP  I +  N +   SQG +  + W G +  S +    L HF ++FK++Y+ K K   YK AI+ A  E   N D+ + +    SP
Sbjct:  469 GVRLLVGDVVWGKIHGFPWWPGKILTITNCN---SQGPQAHVTWYGSSTSSLMQCDQLSHFLDNFKVRYNKK-KKGPYKEAIKQATTEARENADNRVRQPLGNSP 569

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Cavefish
Match: pwwp2a (PWWP domain containing 2A [Source:NCBI gene;Acc:103027727])

HSP 1 Score: 56.225 bits (134), Expect = 1.110e-7
Identity = 32/91 (35.16%), Postives = 47/91 (51.65%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            G    + +IVWAKI G+P+WPA I +     + K  G    +  R++W G    SFL +  L  F E+F+ ++  K K   Y+ AI  A K
Sbjct:  918 GRTICVGDIVWAKILGFPWWPARILAI--TVSRKDNGLLVRQEARVSWFGSPTTSFLAITQLAPFLENFQSRFDKKRKG-LYRKAITEAAK 1005

[Close]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Cavefish
Match: pwwp2b (PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GENE-110930-2])

HSP 1 Score: 51.9878 bits (123), Expect = 1.703e-6
Identity = 25/92 (27.17%), Postives = 48/92 (52.17%), Query Frame = 1

Query: 1051 KGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGK------RCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 1308
            +G   ++ ++VW KI G+P+WPA + S +   + + +G+        +++W G    S L +  L  F E F+++++ K K    +  IE A
Sbjct:  474 EGHAVTVGDVVWGKIHGFPWWPARVLSING--SRRDEGEMDAPWPEAKVSWFGSPTTSQLSVAKLSPFREFFRLRFNRKKKGMYRRAIIEAA 563

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001585.1 (pep scaffold:Pmarinus_7.0:GL478812:497860:498661:1 gene:ENSPMAG00000001433.1 transcript:ENSPMAT00000001585.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 65.0846 bits (157), Expect = 4.804e-13
Identity = 32/92 (34.78%), Postives = 52/92 (56.52%), Query Frame = 1

Query: 1051 KGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQG----KRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            +G    + +IVWAK+ G P+WPA ++S  +VS  +  G    +  ++ W G    SFLPL   + F E+F+ +YS + KS  Y+ A+  A +
Sbjct:   20 QGKVVCVGDIVWAKLHGCPWWPAQVRSV-SVSVQEESGLVLSQEAKMAWFGSTTTSFLPLSQAVPFMENFEARYSRRKKSNGYRRAVSEAAE 110

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Sea Lamprey
Match: pwwp2b (PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GENE-110930-2])

HSP 1 Score: 53.5286 bits (127), Expect = 1.028e-7
Identity = 29/113 (25.66%), Postives = 50/113 (44.25%), Query Frame = 1

Query:  982 LQVKTNNKDDEIHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDN--VSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACK 1314
            L V+    D  I        +   G K  + ++VWAKI G+P+WPA +           + +     ++W G +  S + L  L  F+E F+ +   K K  +Y+ A+  A +
Sbjct:  359 LTVRVRTADSAI-----TECFTPDGRKVHVGDVVWAKIHGFPWWPACVLGLSPELGPGGQQESGEALVSWFGSHTTSAVSLAKLAPFQESFRARLDRKRKG-RYRQAVAEAAR 465

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BLAST of PWWP domain-containing protein 2A vs. Ensembl Nematostella
Match: EDO32351 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVC9])

HSP 1 Score: 56.225 bits (134), Expect = 2.702e-8
Identity = 29/108 (26.85%), Postives = 51/108 (47.22%), Query Frame = 1

Query: 1012 EIHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKR---CRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNL 1326
            E H+N   +  +      +  +I+W K+ G+P+WP  + +   V     QG       + W G N  S +P++ L  FE +F+ +Y  K K   Y+ A+  A + L +
Sbjct:  423 ETHANQPTVIEDCNAASINEGSIIWGKVHGHPWWPGRVMAITEV--VDDQGGVDTFAHVTWFGSNTSSEMPVQELQDFEPNFRRRY-KKDKKGCYRRAVRQAQETLTI 527

[Close]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Medaka
Match: pwwp2b (PWWP domain containing 2B [Source:NCBI gene;Acc:101155875])

HSP 1 Score: 53.5286 bits (127), Expect = 5.167e-7
Identity = 29/108 (26.85%), Postives = 52/108 (48.15%), Query Frame = 1

Query: 1015 IHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDN-----VSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELN 1323
            +H+         +G   ++ +IVW KI G+P+WPA + S        + + ++Q  + ++ W G    S L +  L  F E F+ +++ K K   Y+ AI  A K + 
Sbjct:  505 LHTRSMTKCVTEEGHAVAVGDIVWGKIHGFPWWPARVLSISGTRKQEMPSCEAQWPQAKVAWFGSPTTSQLSVAKLSPFRELFRSRFNRKKKGM-YRRAILEAAKAVG 611

[Close]

BLAST of PWWP domain-containing protein 2A vs. Planmine SMEST
Match: SMESG000031464.1 (SMESG000031464.1)

HSP 1 Score: 997.268 bits (2577), Expect = 0.000e+0
Identity = 510/512 (99.61%), Postives = 510/512 (99.61%), Query Frame = 1

Query:   91 MASNRSIDDVVIGLNLDVEVLSKYNNILLVICNSHNLKGVLLPVNDENKIRLEHFINNYNKENNIEVKPEQESLFCIPDSTLSHSAVESNMSTNLSNNNDVCKKCKRGFKPAKRKLVSKEVERLTNHGFNEVILKKKNISRRTTITKEEFINGEKFKGKINKKRSYDQIKGSDSDLNSADSKVLNEKKDEIVSIRKTKDRALKTKANEKIIDLCTRKPSXXXXXXXXXXXXXXXXHIDEILSDNSPVKVSDASIYDFVDEDYESEPIKPLYKENKKSYFIDKSSNFTKLDKRSYQRKLQVKTNNKDDEIHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSPMSDRNNSSQNSNHGKRKSIDLDDIFPTKKNSKNILDIDMVAKAYSDEDTDEEEKARSALITAESLEANRMMSDMMTKKSEYDYESL 1626
            MASNRSIDDVVIGLNLDVEVLSKYNNILLVICNSHNLKGVLLPVNDENKIRLEHFINNYNKENNIEVKPEQESLFCIPDSTLSHSAVESNMSTNLSNNNDVCKKCKRGFKPAKRKLVSKEVERLTNHGFNEVILKKKNISRRT ITKEEFINGEKFKGKINKKRSYDQIKGSDSDLNSA SKVLNEKKDEIVSIRKTKDRALKTKANEKIIDLCTRKPSKVKENKRELKKKLKLEHIDEILSDNSPVKVSDASIYDFVDEDYESEPIKPLYKENKKSYFIDKSSNFTKLDKRSYQRKLQVKTNNKDDEIHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSPMSDRNNSSQNSNHGKRKSIDLDDIFPTKKNSKNILDIDMVAKAYSDEDTDEEEKARSALITAESLEANRMMSDMMTKKSEYDYESL
Sbjct:    1 MASNRSIDDVVIGLNLDVEVLSKYNNILLVICNSHNLKGVLLPVNDENKIRLEHFINNYNKENNIEVKPEQESLFCIPDSTLSHSAVESNMSTNLSNNNDVCKKCKRGFKPAKRKLVSKEVERLTNHGFNEVILKKKNISRRTAITKEEFINGEKFKGKINKKRSYDQIKGSDSDLNSAGSKVLNEKKDEIVSIRKTKDRALKTKANEKIIDLCTRKPSKVKENKRELKKKLKLEHIDEILSDNSPVKVSDASIYDFVDEDYESEPIKPLYKENKKSYFIDKSSNFTKLDKRSYQRKLQVKTNNKDDEIHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSPMSDRNNSSQNSNHGKRKSIDLDDIFPTKKNSKNILDIDMVAKAYSDEDTDEEEKARSALITAESLEANRMMSDMMTKKSEYDYESL 512

[Close]

BLAST of PWWP domain-containing protein 2A vs. Planmine SMEST
Match: SMESG000059612.1 (SMESG000059612.1)

HSP 1 Score: 82.0333 bits (201), Expect = 5.004e-16
Identity = 42/119 (35.29%), Postives = 70/119 (58.82%), Query Frame = 1

Query: 1054 GTKFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELACKELNLNLDDLIGELPKKSPMSDRNNSSQNSNHG 1410
            G  F+++++VWAKI GYPFWPA I SF   S  +     C I W  WN+ SF+ + +L HF  +F  KY  ++++ KY+ A++LA  + +  + +++     K  +S+RN ++  S  G
Sbjct:  515 GVAFNLSDVVWAKITGYPFWPAKIISF---SQEEDTFIGC-IEWYAWNEISFIKVNNLHHFSTNFPTKYQKRYRNGKYQEAVKLA--KFDCGMVEMVTN--SKLSISERNENTGESVKG 625

[Close]

BLAST of PWWP domain-containing protein 2A vs. Planmine SMEST
Match: SMESG000068720.1 (SMESG000068720.1)

HSP 1 Score: 69.3218 bits (168), Expect = 2.376e-12
Identity = 36/93 (38.71%), Postives = 53/93 (56.99%), Query Frame = 1

Query: 1060 KFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCR----------INWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 1308
            +F+IN+IVWAKI GYPFWP+ I S  N S   +Q   C+          + W+ ++Q S++   +L HF   F  K+S K K++KY  A+  A
Sbjct:  114 EFAINDIVWAKISGYPFWPSKILSI-NRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEA 205

The following BLAST results are available for this feature:

BLAST of PWWP domain-containing protein 2A vs. Ensembl Human
BLAST of PWWP domain-containing protein 2A vs. Ensembl Celegans
BLAST of PWWP domain-containing protein 2A vs. Ensembl Fly
BLAST of PWWP domain-containing protein 2A vs. Ensembl Zebrafish
BLAST of PWWP domain-containing protein 2A vs. Ensembl Xenopus
BLAST of PWWP domain-containing protein 2A vs. Ensembl Mouse
BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
BLAST of PWWP domain-containing protein 2A vs. TrEMBL
BLAST of PWWP domain-containing protein 2A vs. Ensembl Cavefish
BLAST of PWWP domain-containing protein 2A vs. Ensembl Sea Lamprey
BLAST of PWWP domain-containing protein 2A vs. Ensembl Yeast
BLAST of PWWP domain-containing protein 2A vs. Ensembl Nematostella
BLAST of PWWP domain-containing protein 2A vs. Ensembl Medaka
BLAST of PWWP domain-containing protein 2A vs. Planmine SMEST

BLAST of PWWP domain-containing protein 2A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
PWWP2A	4.404e-8	37.36	PWWP domain containing 2A [Source:HGNC Symbol;Acc:...	[more]
PWWP2B	4.736e-7	32.58	PWWP domain containing 2B [Source:HGNC Symbol;Acc:...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein 2A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein 2A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CU855895.3	6.624e-8	35.16	pep chromosome:GRCz11:21:30025031:30030644:-1 gene...	[more]
pwwp2b	8.140e-6	30.93	PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
PWWP2A	1.319e-8	37.36	PWWP domain containing 2A [Source:NCBI gene;Acc:10...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Pwwp2a	1.518e-7	34.78	PWWP domain containing 2A [Source:MGI Symbol;Acc:M...	[more]
Pwwp2b	2.448e-7	32.58	PWWP domain containing 2B [Source:MGI Symbol;Acc:M...	[more]
Pwwp2b	2.448e-7	32.58	PWWP domain containing 2B [Source:MGI Symbol;Acc:M...	[more]
Pwwp2a	3.327e-7	34.78	PWWP domain containing 2A [Source:MGI Symbol;Acc:M...	[more]

BLAST of PWWP domain-containing protein 2A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|F7AQ22\|PWP2A_XENTR	6.979e-8	37.36	PWWP domain-containing protein 2A OS=Xenopus tropi...	[more]
sp\|A0A1L8GR68\|PWP2A_XENLA	1.063e-7	37.36	PWWP domain-containing protein 2A OS=Xenopus laevi...	[more]
sp\|Q96N64\|PWP2A_HUMAN	2.115e-7	37.36	PWWP domain-containing protein 2A OS=Homo sapiens ...	[more]
sp\|Q6NUJ5\|PWP2B_HUMAN	2.274e-6	32.58	PWWP domain-containing protein 2B OS=Homo sapiens ...	[more]
sp\|Q69Z61\|PWP2A_MOUSE	2.327e-6	34.78	PWWP domain-containing protein 2A OS=Mus musculus ...	[more]

BLAST of PWWP domain-containing protein 2A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
J3JYI3	4.424e-9	33.33	PWWP domain-containing protein OS=Dendroctonus pon...	[more]
S4R8P7	6.252e-9	34.78	PWWP domain-containing protein OS=Petromyzon marin...	[more]
A0A3P7NLX8	8.408e-9	35.42	PWWP domain-containing protein (Fragment) OS=Dibot...	[more]
N6TTU4	1.230e-8	33.33	PWWP domain-containing protein (Fragment) OS=Dendr...	[more]
U4U3J2	1.404e-8	33.33	PWWP domain-containing protein OS=Dendroctonus pon...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
pwwp2a	1.110e-7	35.16	PWWP domain containing 2A [Source:NCBI gene;Acc:10...	[more]
pwwp2b	1.703e-6	27.17	PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000001585.1	4.804e-13	34.78	pep scaffold:Pmarinus_7.0:GL478812:497860:498661:1...	[more]
pwwp2b	1.028e-7	25.66	PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein 2A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO32351	2.702e-8	26.85	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of PWWP domain-containing protein 2A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pwwp2b	5.167e-7	26.85	PWWP domain containing 2B [Source:NCBI gene;Acc:10...	[more]

BLAST of PWWP domain-containing protein 2A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000031464.1	0.000e+0	99.61	SMESG000031464.1	[more]
SMESG000059612.1	5.004e-16	35.29	SMESG000059612.1	[more]
SMESG000068720.1	2.376e-12	38.71	SMESG000068720.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033915 ID=SMED30033915|Name=PWWP domain-containing protein 2A|organism=Schmidtea mediterranea sexual|type=transcript|length=1991bp
TTTTGAGTTGTTGATATTTACTTAAATAAATATTGAATTTAACTTTTTTT
GTTATAATGAATTCATTTTGTCCAAATTTTTAAAATCATTATGGCTTCTA
ATAGAAGCATAGATGATGTTGTAATTGGTTTAAATTTAGATGTTGAAGTA
CTTTCAAAGTATAATAATATTTTATTAGTTATTTGTAACAGCCATAATTT
AAAAGGCGTGTTATTGCCTGTTAATGACGAAAACAAAATTCGATTAGAAC
ATTTTATTAATAACTATAATAAAGAAAACAATATTGAAGTAAAACCTGAA
CAAGAAAGCTTATTTTGTATACCCGATTCAACTTTGTCTCATTCAGCAGT
GGAATCAAATATGAGTACCAATCTCAGTAATAATAATGACGTGTGTAAAA
AATGTAAACGTGGTTTCAAACCTGCTAAACGAAAGTTAGTAAGCAAAGAA
GTAGAACGTCTTACAAATCATGGATTTAATGAAGTCATTTTAAAGAAAAA
AAACATATCGAGACGTACTACAATAACTAAAGAAGAATTTATCAATGGAG
AAAAGTTCAAAGGAAAAATTAATAAAAAGAGATCGTATGATCAAATTAAG
GGAAGTGATTCCGATTTAAACAGTGCTGATTCTAAAGTTTTAAATGAAAA
AAAGGACGAAATAGTATCCATTCGAAAAACTAAAGACAGGGCTCTTAAAA
CAAAGGCCAATGAAAAGATAATTGATTTATGTACTAGAAAGCCAAGTAAG
GTCAAAGAGAACAAACGAGAATTAAAAAAGAAATTAAAATTAGAACATAT
AGATGAAATATTATCTGATAATTCGCCAGTGAAAGTATCAGATGCATCTA
TATATGATTTTGTCGACGAAGATTATGAATCTGAACCCATAAAACCTTTA
TATAAAGAAAATAAAAAATCTTACTTCATAGATAAAAGCAGTAATTTTAC
GAAACTTGATAAACGAAGCTATCAACGAAAGTTACAAGTAAAGACTAATA
ATAAAGATGATGAAATTCATTCAAATCCTGGCATCATGTTTTATGAACAC
AAGGGCACTAAATTTAGCATAAATAACATAGTCTGGGCTAAAATTCCAGG
CTATCCATTTTGGCCAGCACATATTAAGTCCTTCGATAATGTAAGTGCCT
CGAAATCTCAGGGTAAAAGGTGTCGGATTAATTGGATTGGTTGGAATCAA
AAGTCGTTTCTACCGCTTAAATCGCTCTTACATTTTGAAGAGCATTTCAA
AATGAAATATTCAGCTAAGTTTAAATCACAAAAGTATAAAACCGCTATTG
AACTCGCTTGTAAAGAATTGAATTTAAATCTTGATGATTTGATAGGAGAA
TTGCCTAAAAAATCACCAATGTCGGATAGGAATAATTCTTCACAAAATTC
AAATCATGGAAAAAGGAAATCAATAGATCTAGATGACATTTTCCCTACTA
AGAAAAATTCAAAAAATATTTTAGACATTGATATGGTCGCCAAAGCGTAT
TCAGATGAAGATACGGATGAAGAGGAGAAAGCTCGATCTGCCTTAATCAC
AGCAGAAAGTTTAGAAGCAAACAGAATGATGTCGGATATGATGACAAAAA
AGTCTGAATATGATTATGAAAGTCTGTAAAAAAGTTTTTTGTAATATTTA
ACATTTGTACACATTTATTTTTACTTATACTCCAGAACGGATTTTTGTAT
AAATTATTAATTTATCCTTGCAAGATACATTTGTACAAATTTATTTCATT
GAATTTATAACTTGATAATTGTAAACTGTGATCAATTGTTTAATGTGTCT
TATTAATACTTTGCATGGTGGGATTTTAAATAAATTTTCAATTGACTTAG
TTTCTAATTATGCCAAATGATTTCTTACTGTAAAATTTTGTAAATGTAGC
CACGTTGATATTTCAATAAATCACTGGAAACGTTATCCGTTATTACAGAA
TTTATTATTGCAAACATATTTGTTCAAACGTGTTGGATCGC

protein sequence of SMED30033915-orf-1

>SMED30033915-orf-1 ID=SMED30033915-orf-1|Name=SMED30033915-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=513bp
MASNRSIDDVVIGLNLDVEVLSKYNNILLVICNSHNLKGVLLPVNDENKI
RLEHFINNYNKENNIEVKPEQESLFCIPDSTLSHSAVESNMSTNLSNNND
VCKKCKRGFKPAKRKLVSKEVERLTNHGFNEVILKKKNISRRTTITKEEF
INGEKFKGKINKKRSYDQIKGSDSDLNSADSKVLNEKKDEIVSIRKTKDR
ALKTKANEKIIDLCTRKPSKVKENKRELKKKLKLEHIDEILSDNSPVKVS
DASIYDFVDEDYESEPIKPLYKENKKSYFIDKSSNFTKLDKRSYQRKLQV
KTNNKDDEIHSNPGIMFYEHKGTKFSINNIVWAKIPGYPFWPAHIKSFDN
VSASKSQGKRCRINWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYK
TAIELACKELNLNLDDLIGELPKKSPMSDRNNSSQNSNHGKRKSIDLDDI
FPTKKNSKNILDIDMVAKAYSDEDTDEEEKARSALITAESLEANRMMSDM
MTKKSEYDYESL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0001654	eye development
GO:0001755	neural crest cell migration
GO:0014033	neural crest cell differentiation
GO:0060322	head development

Vocabulary: **molecular function**
Term	Definition
GO:0003682	chromatin binding
GO:0005515	protein binding

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000313	PWWP_dom

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000313	PWWP domain	PFAM	PF00855	PWWP	coord: 325..409 e-value: 1.2E-10 score: 41.6
IPR000313	PWWP domain	PROSITE	PS50812	PWWP	coord: 327..385 score: 11.417
None	No IPR available	GENE3D	G3DSA:2.30.30.140		coord: 316..418 e-value: 1.5E-18 score: 68.7
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 426..440
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 423..448
None	No IPR available	SUPERFAMILY	SSF63748	Tudor/PWWP/MBT	coord: 322..418

Main menu

PWWP domain-containing protein 2A

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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