FERM, RhoGEF and pleckstrin domain-containing protein 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033884 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Human
Match: FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:HGNC Symbol;Acc:HGNC:16460]) HSP 1 Score: 235.728 bits (600), Expect = 4.116e-65 Identity = 123/294 (41.84%), Postives = 179/294 (60.88%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++VK LD+ +E F + G L ++ R+ L+E +FG+++ + S WL+ K I +Q + + VKF+ PDP L + T+ LF LQLK+D+ L C+++T LL ++ + + +E LD + HL ++ L + +E+ L+FHQ QT E+ F +LEI RK++ YG++ H A D EG + LAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDE-TLDRE-----HLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Human
Match: FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:HGNC Symbol;Acc:HGNC:16460]) HSP 1 Score: 236.113 bits (601), Expect = 4.448e-65 Identity = 123/294 (41.84%), Postives = 179/294 (60.88%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++VK LD+ +E F + G L ++ R+ L+E +FG+++ + S WL+ K I +Q + + VKF+ PDP L + T+ LF LQLK+D+ L C+++T LL ++ + + +E LD + HL ++ L + +E+ L+FHQ QT E+ F +LEI RK++ YG++ H A D EG + LAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDE-TLDRE-----HLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Human
Match: FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:HGNC Symbol;Acc:HGNC:16460]) HSP 1 Score: 234.958 bits (598), Expect = 2.479e-62 Identity = 123/294 (41.84%), Postives = 179/294 (60.88%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++VK LD+ +E F + G L ++ R+ L+E +FG+++ + S WL+ K I +Q + + VKF+ PDP L + T+ LF LQLK+D+ L C+++T LL ++ + + +E LD + HL ++ L + +E+ L+FHQ QT E+ F +LEI RK++ YG++ H A D EG + LAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDE-TLDRE-----HLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321 HSP 2 Score: 98.9821 bits (245), Expect = 4.434e-20 Identity = 86/325 (26.46%), Postives = 145/325 (44.62%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASI------------TIKSRLNHSPQEIVSKINSPNQTKF------WTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
E+ ++ L + N+++LT + + I+ L EF IR G L KL+ KG R+F L D L+ + K + R L G + E ++ N + V TI + ++ + A T + W+ D+ +A A+ T+ +R SP E+ + S + + ++R + +CW+ S+S+ LS Y+LRK+K+S+ WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P D I K +V KL+ + F R E++Y + RW
Sbjct: 718 EVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGR-EF--------IREGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLP--LQGMLVE--ESDNEWSVP----HCFTIYA--------AQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERW 1017
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Human
Match: FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1 [Source:HGNC Symbol;Acc:HGNC:3591]) HSP 1 Score: 220.32 bits (560), Expect = 1.003e-58 Identity = 121/296 (40.88%), Postives = 178/296 (60.14%), Query Frame = 2
Query: 170 SGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
SG L++IK++ LDD E F + + + G L + + L+E +FGL++ WLDL K I KQ + + VKF+ PD L + LT+ LF LQ+K+D+ G L C++++ LL ++ + + +E LD +E + + Q + E ++ ++FH QT E+ F LLEI R+++ YG++LHPAKD EG +NLAV + GI++FQ +TKIN FNW+K+RKLSFKRKRFL+KL P+ Y+DTLEF SR+ CK+FWK C+EHH FFR
Sbjct: 36 SGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEA-LD-REHLAKNKYIPQQDALE--DKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPD----------ANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFR 317
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Human
Match: FRMD7 (FERM domain containing 7 [Source:HGNC Symbol;Acc:HGNC:8079]) HSP 1 Score: 215.698 bits (548), Expect = 8.605e-58 Identity = 120/298 (40.27%), Postives = 177/298 (59.40%), Query Frame = 2
Query: 179 LINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLK-----FHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++KV++LDD + F +++ S G LF + L E +FGL++ S + WL+L K I KQ E+ ++ VKF+ DP L + LT+ LF LQ+KKD+ G L CS++ L+ ++ + + E + D K HL + L ++ CL+ FHQ ++ E+ LL+I RK+D YG++ HPA D EG+ ++LAV HMG+++ + TKINTFNW+KIRKLSFKRK FL+KLH + VL KDTLEF SR++CK FWK C+E+H FFR
Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHE-ETDRK-----HLAQTRYLPNQ---DCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLH----ANILVLC------KDTLEFTMASRDACKAFWKTCVEYHAFFR 279
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Celegans
Match: frm-3 (FERM domain (Protein4.1-ezrin-radixin-moesin) family [Source:UniProtKB/TrEMBL;Acc:G5EDC0]) HSP 1 Score: 288.115 bits (736), Expect = 5.710e-80 Identity = 287/1110 (25.86%), Postives = 495/1110 (44.59%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQ-TDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQ--------YPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQ--KHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHC---LQFGNHTAVNLTADGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVN--NSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSD----------SFNCDKSTCLPSDSTEVI-------SYQTILQSIEKDLLFNGFMYLKELEIIFK-ILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNL----KCYIEEIKTFIYALNQCEYSSDCF----DKFQFENDGESETNFLRL-LLSPIIQQRAHXXXXXXXXXXXXXDEEEKQ----ICQEIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLN---FSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIED----IRNAASASITIKSRLNHSPQE---IVSKINSPNQTKFWTEKYRLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCH-LFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSW-VIKLEKELKTCFLRIENEYFYHRW 3325
G L+ IKV+ LDD V F + ++G L ++ + L+E +FGL ++ ++ + CWLD K I +Q T+ + + VKFYTP+P L + T+ LF +Q+K+D+ GEL CS++T LL ++ + YP++ +L H N + EF ++ + H+ T E+ +LE+ R+ DFYG+KLH AKD +G L+V H+GI +F++ TF+W++IRKLSFKRK+ LVKLHP+ Y + K+T+EF FE+R+ CKNFWKKC+EHH FFR C+++ + K GS FRY G TQ +L +E ++ F R LR + + Y S + L N V E + N + N H + + +H +Q + +VN D + +ST S+E + + K NK + + S D E+N NS D + SI D A + L + S + ++ ++T+ S D PS S+E + L ++ K+ + +Y K++ +I + ++ KD V + C+ K + +L E+ + +++ L + E D A++ HNL + ++ ++ AL+Q S F KF+ + ++ N++ L +L+ +I + ++ + L ++ E +II K+T + ++EE H VL + GL +I +R+G++ + + + R+ +L D+++ + +L+ F+V + L + M + Y+V + IT+ D S+ A R+ WIED I+NAA A I + S + +E ++K+ P ++ K + ICW+ + S ++ + ++ Y+ RK ++S+ WQ LWVV+ CH L+FY+NH ++ +A L L+ + + P + D I KL T F R ++ YF+ RW
Sbjct: 34 GRLVCIKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGLSFIDINGNHCWLDREKTILRQITNGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLALGELHCSDNTASLLSAYLVQSECGDFSSEDYPDA---------TYLSHTRFVPNQTLEFQKKVMDNHRNFIGMTPGESDLAMLEVARRCDFYGVKLHAAKDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFKRKKLLVKLHPDSY----------QYLKETVEFSFETRDECKNFWKKCVEHHAFFR---------CVQAEEPKKETRFFISKGSSFRYHGRTQKQLIDYVREHHKRREPFTRP-------------LRSAASTRKGTYSSTYGLVTDRPTKHRNGSVYEPNQTDPYNKHQ---NTHSSMPHIAHISSQPADHSFSDIQEPLYQSVNKKKDVIVGINSTFSSE---TICTSEPILKVNK------KPRKRMSRSANDTSELNKYNSSD--------SGGLSIGDPTAGSNDSLRLMKRDHSSDYQLRHDYAVMRTSQSTASVGTPSKEIEMSLENDVDNYPPSCSSEYYITRKDFGKPEPQLANVLKEFYWKELVYSKDMRLINESFFNKIKDDV-VDCRFLKELFGSLKELPPIHQPLIDALRE----------SSNEPEDSKAAMVAPVLLATVHNLTPLYQSLVQNFPIYVSALDQLYRSKIPFRTIMSKFESSKECYTQVNWILLKILNRLINWQPVLARVIEIQLSECGNDTETTAFGVAMDKIIEFAKKTKATRQSLEEYIH-VLQVERDTGLVGILTHPNRKI-----LRVGFVLRSARRAPCCRIMVLCSDRILFGHRGVNLDGNFFTVHAEFKLKGM-------MIDEGDTYKVMDGENNVITLHNAD--------ISIVFAA---PDRASWIEDITEAIKNAARAKIDLPSLVMEKKEENDIDMTKVLLPEESP--VSKMSPLQICWYRKCSFGRKDVNKMITNTMCGYLKRKLRNSSGWQDLWVVMC-CHTLYFYRNHNEREPLAHLSLMDYGVGLPTVADKIDNHENCFKLFYGSHTYFFRTDSYYFFERW 1044
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Celegans
Match: frm-3 (FERM domain (Protein4.1-ezrin-radixin-moesin) family [Source:UniProtKB/TrEMBL;Acc:G5EDC0]) HSP 1 Score: 229.95 bits (585), Expect = 3.903e-61 Identity = 117/304 (38.49%), Postives = 178/304 (58.55%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQ-TDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQ--------YPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
G L+ IKV+ LDD V F + ++G L ++ + L+E +FGL ++ ++ + CWLD K I +Q T+ + + VKFYTP+P L + T+ LF +Q+K+D+ GEL CS++T LL ++ + YP++ +L H N + EF ++ + H+ T E+ +LE+ R+ DFYG+KLH AKD +G L+V H+GI +F++ TF+W++IRKLSFKRK+ LVKLHP+ Y + K+T+EF FE+R+ CKNFWKKC+EHH FFR
Sbjct: 22 GRLVCIKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGLSFIDINGNHCWLDREKTILRQITNGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLALGELHCSDNTASLLSAYLVQSECGDFSSEDYPDA---------TYLSHTRFVPNQTLEFQKKVMDNHRNFIGMTPGESDLAMLEVARRCDFYGVKLHAAKDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFKRKKLLVKLHPDSYQ----------YLKETVEFSFETRDECKNFWKKCVEHHAFFR 306
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Celegans
Match: ptp-1 (Tyrosine-protein phosphatase 1 [Source:UniProtKB/Swiss-Prot;Acc:P28191]) HSP 1 Score: 143.665 bits (361), Expect = 3.336e-34 Identity = 92/304 (30.26%), Postives = 148/304 (48.68%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLC----WLDLRKVIKKQTDYKNELAYEIC--------VKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
I V +LD F + +NSLG L +K+ +++IE +FGL ++++D+ WLD K ++KQ IC VKFY DPN L D T+ F Q+++++ G L C+E + LL ++ + + EE + L + L +F ++ + HQ QT + + L+ R+++ YGM ++ D L + + V +GI +F + K+N + W +IRKLSFK+K+F V + E+ G + + F S CK WK CIE HTFFR
Sbjct: 29 IRCTVTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFIAVDNSSAQQKKWLDPSKNLRKQM---------ICPPYHLFFRVKFYVRDPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFEEKTHGMSRTCLCYKIQFATLPDDFSDRVAELHQLHIGQTPDVAEQNFLDHARRLEMYGMDVYDGVDANHLPIEIGVGAVGIKVFHEGIKMNEYAWVRIRKLSFKKKQFQVLVANED-----------GVSETIMIFNIMSAKICKLLWKCCIEQHTFFR 312
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Celegans
Match: ptp-1 (Tyrosine-protein phosphatase 1 [Source:UniProtKB/Swiss-Prot;Acc:P28191]) HSP 1 Score: 143.665 bits (361), Expect = 3.336e-34 Identity = 92/304 (30.26%), Postives = 148/304 (48.68%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLC----WLDLRKVIKKQTDYKNELAYEIC--------VKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
I V +LD F + +NSLG L +K+ +++IE +FGL ++++D+ WLD K ++KQ IC VKFY DPN L D T+ F Q+++++ G L C+E + LL ++ + + EE + L + L +F ++ + HQ QT + + L+ R+++ YGM ++ D L + + V +GI +F + K+N + W +IRKLSFK+K+F V + E+ G + + F S CK WK CIE HTFFR
Sbjct: 29 IRCTVTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFIAVDNSSAQQKKWLDPSKNLRKQM---------ICPPYHLFFRVKFYVRDPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFEEKTHGMSRTCLCYKIQFATLPDDFSDRVAELHQLHIGQTPDVAEQNFLDHARRLEMYGMDVYDGVDANHLPIEIGVGAVGIKVFHEGIKMNEYAWVRIRKLSFKKKQFQVLVANED-----------GVSETIMIFNIMSAKICKLLWKCCIEQHTFFR 312
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Celegans
Match: ptp-1 (Tyrosine-protein phosphatase 1 [Source:UniProtKB/Swiss-Prot;Acc:P28191]) HSP 1 Score: 143.665 bits (361), Expect = 3.336e-34 Identity = 92/304 (30.26%), Postives = 148/304 (48.68%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLC----WLDLRKVIKKQTDYKNELAYEIC--------VKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
I V +LD F + +NSLG L +K+ +++IE +FGL ++++D+ WLD K ++KQ IC VKFY DPN L D T+ F Q+++++ G L C+E + LL ++ + + EE + L + L +F ++ + HQ QT + + L+ R+++ YGM ++ D L + + V +GI +F + K+N + W +IRKLSFK+K+F V + E+ G + + F S CK WK CIE HTFFR
Sbjct: 29 IRCTVTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFIAVDNSSAQQKKWLDPSKNLRKQM---------ICPPYHLFFRVKFYVRDPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFEEKTHGMSRTCLCYKIQFATLPDDFSDRVAELHQLHIGQTPDVAEQNFLDHARRLEMYGMDVYDGVDANHLPIEIGVGAVGIKVFHEGIKMNEYAWVRIRKLSFKKKQFQVLVANED-----------GVSETIMIFNIMSAKICKLLWKCCIEQHTFFR 312
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Fly
Match: Cdep (gene:FBgn0265082 transcript:FBtr0336810) HSP 1 Score: 251.521 bits (641), Expect = 2.505e-73 Identity = 142/361 (39.34%), Postives = 208/361 (57.62%), Query Frame = 2
Query: 167 NSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDL-CWLDLRKVIKKQTDYK-NELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQR 1219
G + ++++ LDD + F + +LG LF+++ ++ L+E+ +FGL+Y + + WLDL K + +Q + C+KFYTPDP L + T+ LF LQ+K+D+ G L C+++T L+ G F+ YP+ L +F+ + D + + +E H+ Q+ E +LLE R+ + YGMK+HPAKD EG+ LNLAV HMGI +FQ T+INTF+W+KIRK+SFKRKRFLVKLHPE Y G+YKDT+EF+FE RN CKNFWKKC+E+H FFR + +++ + R GS FRY G TQ ++ + +E Y FQR
Sbjct: 64 RGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLS---SYRFVPN--QDATMQRKIMEN----HKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGY----------GYYKDTVEFFFEGRNECKNFWKKCVENHGFFR-------CTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQR 398
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Fly
Match: Cdep (gene:FBgn0265082 transcript:FBtr0336809) HSP 1 Score: 256.144 bits (653), Expect = 4.126e-69 Identity = 144/364 (39.56%), Postives = 211/364 (57.97%), Query Frame = 2
Query: 167 NSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDL-CWLDLRKVIKKQTDYK-NELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSES 1228
G + ++++ LDD + F + +LG LF+++ ++ L+E+ +FGL+Y + + WLDL K + +Q + C+KFYTPDP L + T+ LF LQ+K+D+ G L C+++T L+ G F+ YP+ L +F+ + D + + +E H+ Q+ E +LLE R+ + YGMK+HPAKD EG+ LNLAV HMGI +FQ T+INTF+W+KIRK+SFKRKRFLVKLHPE Y G+YKDT+EF+FE RN CKNFWKKC+E+H FFR + +++ + R GS FRY G TQ ++ + +E Y FQRS+S
Sbjct: 64 RGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLS---SYRFVPN--QDATMQRKIMEN----HKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGY----------GYYKDTVEFFFEGRNECKNFWKKCVENHGFFR-------CTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQS 401 HSP 2 Score: 87.0409 bits (214), Expect = 1.303e-16 Identity = 40/117 (34.19%), Postives = 67/117 (57.26%), Query Frame = 2
Query: 2999 IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCT 3349
+ +CWH ++ LS Y+LRK+K+S+ WQ+LWVV + L+FY+++ + A+ASL L+G+ + P +D++ K +V KL + F R E+ + Y+RW L T
Sbjct: 1035 LHVCWHRGATVGLGDHLIAAEHQLSGYLLRKFKNSSGWQKLWVVFTSFCLYFYKSYQDEFALASLPLLGYTVGPPGHQDAVQKEFVFKLSFKNHVYFFRAESAHTYNRWLEVLRSTT 1151
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Fly
Match: Cdep (gene:FBgn0265082 transcript:FBtr0336811) HSP 1 Score: 246.514 bits (628), Expect = 4.728e-66 Identity = 141/364 (38.74%), Postives = 207/364 (56.87%), Query Frame = 2
Query: 167 NSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDL-CWLDLRKVIKKQTDYK-NELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSES 1228
G + ++++ LDD + F + +LG LF+++ ++ L+E+ +FGL+Y + + WLDL K + +Q + C+KFYTPDP L + T+ LF LQ+K+D+ G L C+++T L+ G F+ YP+ L +F+ + D + + +E H+ Q+ E +LLE R+ + YGMK+HPAKD EG+ LNLAV HMGI +FQ T+INTF+W+KIRK+SFKRKRFLVKLHPE Y DT+EF+FE RN CKNFWKKC+E+H FFR + +++ + R GS FRY G TQ ++ + +E Y FQRS+S
Sbjct: 64 RGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLS---SYRFVPN--QDATMQRKIMEN----HKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGY--------------DTVEFFFEGRNECKNFWKKCVENHGFFR-------CTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQS 397 HSP 2 Score: 86.6557 bits (213), Expect = 1.452e-16 Identity = 40/117 (34.19%), Postives = 67/117 (57.26%), Query Frame = 2
Query: 2999 IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCT 3349
+ +CWH ++ LS Y+LRK+K+S+ WQ+LWVV + L+FY+++ + A+ASL L+G+ + P +D++ K +V KL + F R E+ + Y+RW L T
Sbjct: 1031 LHVCWHRGATVGLGDHLIAAEHQLSGYLLRKFKNSSGWQKLWVVFTSFCLYFYKSYQDEFALASLPLLGYTVGPPGHQDAVQKEFVFKLSFKNHVYFFRAESAHTYNRWLEVLRSTT 1147
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Fly
Match: Cdep (gene:FBgn0265082 transcript:FBtr0336812) HSP 1 Score: 247.669 bits (631), Expect = 1.749e-65 Identity = 144/362 (39.78%), Postives = 211/362 (58.29%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDL-CWLDLRKVIKKQTDYK-NELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSES 1228
G + ++++ LDD + F + +LG LF+++ ++ L+E+ +FGL+Y + + WLDL K + +Q + C+KFYTPDP L + T+ LF LQ+K+D+ G L C+++T L+ G F+ YP+ L +F+ + D + + +E H+ Q+ E +LLE R+ + YGMK+HPAKD EG+ LNLAV HMGI +FQ T+INTF+W+KIRK+SFKRKRFLVKLHPE Y G+YKDT+EF+FE RN CKNFWKKC+E+H FFR + +++ + R GS FRY G TQ ++ + +E Y FQRS+S
Sbjct: 66 GKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLS---SYRFVPN--QDATMQRKIMEN----HKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGY----------GYYKDTVEFFFEGRNECKNFWKKCVENHGFFR-------CTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQS 401
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Fly
Match: cora (gene:FBgn0010434 transcript:FBtr0301279) HSP 1 Score: 172.555 bits (436), Expect = 6.020e-44 Identity = 92/291 (31.62%), Postives = 153/291 (52.58%), Query Frame = 2
Query: 191 KVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKK--QTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+V LD + +++ ++G D+ I + LIE +FGL Y + WLDL K + K +TD VKFY P+P+ L +++T+ LQ++ DI G L C+ T LLG ++ + + + ++ + +L N ++E ++ + H+T K Q+ E LE +K+ YG+ LHPAKD+EG+ + L V G+++++ +IN F W KI K+S+KR F +K+ P E+ + Y+ T+ F + + K WK C+EHHTFFR
Sbjct: 35 RVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSKFFRTDT---WPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTR-AYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQ----------YESTIGFKLANHRAAKKLWKSCVEHHTFFR 311
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Zebrafish
Match: FRMD7 (si:ch211-243g6.3 [Source:ZFIN;Acc:ZDB-GENE-121214-124]) HSP 1 Score: 232.261 bits (591), Expect = 1.354e-67 Identity = 124/312 (39.74%), Postives = 189/312 (60.58%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSS-EFIE-QCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHI 1111
+ ++V +LDD F + +GSD F K+ ++L+E +FGL++ + WL+L K + KQ +++A+ VKF+ PDP L LT+ LF LQ+K+D++NG L C++++ LL ++ + + ++ +LD HL N Q + + E+++ + ++FH+ + T E+ LLE+ RK+D YG++ HPA D EG+ +NLAV HMG+++FQ TKINTF+W+KIRKLSFKRK FL+KLH E +DT+EF SR+ CK FWK C+E+H FFR T KSHQK I
Sbjct: 25 LRLRVIFLDDSERVFEVERKIMGSDFFNKVCGHLKLLEKEYFGLEFRHHNGSFVWLELLKPVAKQIKNTSDVAFHFIVKFFPPDPGQLQKGLTRYLFALQIKQDLSNGSLTCNDNSAALLVSHILQAEIGDYDD-ELDAH-----HLENKQYVPNQEYLDHKIIRFHKKNRGHTPGESDVHLLEVARKMDMYGIRPHPAHDGEGMRINLAVTHMGVLVFQGNTKINTFSWAKIRKLSFKRKHFLIKLHTE----------TGPSRRDTVEFSMASRDVCKAFWKMCVEYHAFFR------LTEEPKSHQKSI 314
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Zebrafish
Match: farp2 (FERM, RhoGEF and pleckstrin domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2993]) HSP 1 Score: 238.424 bits (607), Expect = 9.769e-64 Identity = 120/292 (41.10%), Postives = 177/292 (60.62%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+V+ LD+ E + + + G L + R+ LIES +FGL++ +L + WLD K+I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ +G L C+E+T LL ++ + + + D+ ++ + + E+ ++ H+ QT E+ F +LEI RK++ +G++ HPA D EG +NLAV HMG+ +FQ +TKINTFNWSKIRKLSFKRKRFL+KLHPE V G ++DTLEF SR+ CK FWK C+EHH+FFR
Sbjct: 51 LQIRVQGLDEAQEFYELESKADGQLLLSDVFRRINLIESDYFGLEFQNLQMNWVWLDPSKLIVKQVRRPMNTLFRLSVKFFPPDPGQLQEEFTRYLFSLQIKRDLLDGRLSCTENTAALLASHLVQSEIGDYD----DLADREFLKMNKLLPCQEHVQEKIMELHRRHTGQTPAESDFQVLEIARKLEMFGVRFHPAADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPE----------VHGPHQDTLEFLMGSRDQCKIFWKNCVEHHSFFR 328 HSP 2 Score: 104.76 bits (260), Expect = 5.220e-22 Identity = 97/327 (29.66%), Postives = 147/327 (44.95%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLV-CSKKIPSLN-FSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASAS------------ITIKSRLNHSPQEIV------SKINSPNQTKFWTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
EI Q++ +L + N ++LT + + I+ L EF IR G L KL+ KG R+F L D L+ SK + + N F V + L G I E ++ N + V TI + ++ + A + + WIED+ A S ++ R N S E+ +NS + +R + +CWH S+S LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P DSI K +V KL+ + F R E+EY + RW
Sbjct: 716 EIATQLQSSLIRLENFQKLTELQRDLIGIENL-TAPGREF--------IREGCLYKLTKKGLQQRMFFLFSDMLLYTSKGVTATNQFKVHGQLPLH----GMIVE--ESENEWSVPHC----FTIY--------SAQRTIVVAASSKVEMNKWIEDLNMAIEMSKKCQEKSDVLLDPSLCDRSNRSSDEVSLEQESEDDMNSSRCSLDKQSHHRANTTMHVCWHRNTSVSMSDHSLAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVSTPGESDSIHKEYVFKLQFKSHVYFFRAESEYTFERW 1015
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Zebrafish
Match: farp1 (FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) [Source:ZFIN;Acc:ZDB-GENE-070424-163]) HSP 1 Score: 231.491 bits (589), Expect = 1.414e-62 Identity = 119/297 (40.07%), Postives = 177/297 (59.60%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
G I+I+V+ LDD E F +++ + G LF + + L+E +FGL++ + WLDL K I KQ + VKF+ PD L + LT+ LF LQ+K D+ G L C+ES+ LL ++ + + +E+Q HL N++ + + +++ + +H+ QT E+ + LLEI R+++ YG++LHPAKD EG L+LAV H G+++FQ +TKIN FNWSK+RKLSFKRKRFL+KL P+ + +DTLEF SR+ CK FWK C+E+H FFR
Sbjct: 38 GRQISIRVQMLDDTQEVFEVSQRAPGKALFDLVCSHLNLVEGDYFGLEFQDQRKMIVWLDLLKPILKQIRRPKNIILRFVVKFFPPDHTQLLEELTRYLFALQIKHDLACGRLTCNESSAALLVAHIVQSEIGDFDEVQCKQ------HLLNNKYIPEQDTLMDKIIGYHRKHVGQTPAESDYQLLEIARRLEMYGVRLHPAKDREGTRLSLAVAHSGVLVFQGHTKINAFNWSKVRKLSFKRKRFLIKLRPD----------LNSNCQDTLEFMMGSRDCCKVFWKICVEYHAFFR 318
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Zebrafish
Match: si:ch211-243g6.3 (si:ch211-243g6.3 [Source:ZFIN;Acc:ZDB-GENE-121214-124]) HSP 1 Score: 212.231 bits (539), Expect = 8.015e-61 Identity = 120/311 (38.59%), Postives = 181/311 (58.20%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSS-EFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHI 1111
+ ++V +LDD F + +GSD F K+ ++L+E +FGL++ + WL+L K + KQ +++A+ VKF+ PDP L LT+ LF LQ+K+D++NG L C++++ LL ++ + + ++ +LD HL N Q + + E+++ H+ ++ T E+ LLE+ RK+D YG++ HPA D EG+ +NLAV HMG+++FQ TKINTF+W+KIRKLSFKRK FL+KLH E F SR+ CK FWK C+E+H FFR T KSHQK I
Sbjct: 25 LRLRVIFLDDSERVFEVERKIMGSDFFNKVCGHLKLLEKEYFGLEFRHHNGSFVWLELLKPVAKQIK-SDDVAFHFIVKFFPPDPGQLQKGLTRYLFALQIKQDLSNGSLTCNDNSAALLVSHILQAEIGDYDD-ELDAH-----HLENKQYVPNQEYLD-----HKIIR-HTPGESDVHLLEVARKMDMYGIRPHPAHDGEGMRINLAVTHMGVLVFQGNTKINTFSWAKIRKLSFKRKHFLIKLHTET------------------GFSMASRDVCKAFWKMCVEYHAFFR------LTEEPKSHQKSI 298
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Zebrafish
Match: FRMD7 (si:ch211-243g6.3 [Source:ZFIN;Acc:ZDB-GENE-121214-124]) HSP 1 Score: 212.231 bits (539), Expect = 8.015e-61 Identity = 120/311 (38.59%), Postives = 181/311 (58.20%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSS-EFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHI 1111
+ ++V +LDD F + +GSD F K+ ++L+E +FGL++ + WL+L K + KQ +++A+ VKF+ PDP L LT+ LF LQ+K+D++NG L C++++ LL ++ + + ++ +LD HL N Q + + E+++ H+ ++ T E+ LLE+ RK+D YG++ HPA D EG+ +NLAV HMG+++FQ TKINTF+W+KIRKLSFKRK FL+KLH E F SR+ CK FWK C+E+H FFR T KSHQK I
Sbjct: 25 LRLRVIFLDDSERVFEVERKIMGSDFFNKVCGHLKLLEKEYFGLEFRHHNGSFVWLELLKPVAKQIK-SDDVAFHFIVKFFPPDPGQLQKGLTRYLFALQIKQDLSNGSLTCNDNSAALLVSHILQAEIGDYDD-ELDAH-----HLENKQYVPNQEYLD-----HKIIR-HTPGESDVHLLEVARKMDMYGIRPHPAHDGEGMRINLAVTHMGVLVFQGNTKINTFSWAKIRKLSFKRKHFLIKLHTET------------------GFSMASRDVCKAFWKMCVEYHAFFR------LTEEPKSHQKSI 298
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Xenopus
Match: hpse (heparanase [Source:Xenbase;Acc:XB-GENE-1004201]) HSP 1 Score: 214.157 bits (544), Expect = 2.504e-61 Identity = 115/295 (38.98%), Postives = 180/295 (61.02%), Query Frame = 2
Query: 179 LINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSS-EFIE-QCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++KV++LDD + F +++ + G +LF + L E +FGL++ + WL L K I KQ + E ++ VKF+ DP LL LT+ LF LQ+KK++ +G+L C++++ L+ ++ + + EE D + HL +Q L + E+++ + LK++Q ++ E+ LL+I RK+D YG++ H A D EG+ +NLAV HMG+++ + TKINTFNW+ IRKLSFKRK FL+KLHP + KDTL F ESR++CK FWK C+E+H FFR
Sbjct: 1 MLHLKVQFLDDSQKTFVVDQKAPGKELFNMSCSHLNLTEKEYFGLEFRNHAGCQMWLGLLKPITKQVKHPKETIFKFMVKFFLVDPGLLKGELTRYLFALQIKKNLASGKLPCNDNSAALMASYVLQSELGDFEE---DTARK---HLEQNQYLPNQEYLDNKILKYYQRHVGKSPAESDMQLLDIARKLDTYGIRPHAASDGEGMQINLAVAHMGVLVLRGNTKINTFNWANIRKLSFKRKHFLIKLHPH----------IDTLCKDTLVFTMESRDACKAFWKSCVEYHAFFR 279
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Xenopus
Match: pdcd6ip (programmed cell death 6 interacting protein [Source:Xenbase;Acc:XB-GENE-1194420]) HSP 1 Score: 211.846 bits (538), Expect = 2.750e-59 Identity = 106/288 (36.81%), Postives = 165/288 (57.29%), Query Frame = 2
Query: 194 VKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
V LD + + G L ++ + ++E+ +FG+++ + + WL+ K + KQ + VKF+ PDP L + T+ LF LQ+K+D+ +L+C +ST LL L ++ + + ++ + Q ++ +L ++ +K+HQ + + F +LEI R++D YG + H A D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKR+RFL+KLHPE V G Y+D LEF SR++CK FWK C+E+H+FFR
Sbjct: 54 VLLLDSSTLPLEIGPKTTGQALLSQLFTHLNVVETDYFGIEFQTAQAQWVWLEPLKSVNKQLRKPKNAKLRLAVKFFPPDPGQLQEEYTRYLFALQIKRDLEEEKLVCFDSTTALLISLLLQSEIGDYDQKVVQDHLQNTYYVQRQHSLE----DRIMKYHQQHIGMSPGDADFQILEIARRLDLYGTRFHLASDREGAKINLSVSHMGVLVFQGSTKINTFNWSKIRKLSFKRRRFLIKLHPE----------VHGPYQDALEFLLPSRDTCKRFWKICVEYHSFFR 327
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Xenopus
Match: pdcd6ip (programmed cell death 6 interacting protein [Source:Xenbase;Acc:XB-GENE-1194420]) HSP 1 Score: 213.772 bits (543), Expect = 8.356e-59 Identity = 106/288 (36.81%), Postives = 165/288 (57.29%), Query Frame = 2
Query: 194 VKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
V LD + + G L ++ + ++E+ +FG+++ + + WL+ K + KQ + VKF+ PDP L + T+ LF LQ+K+D+ +L+C +ST LL L ++ + + ++ + Q ++ +L ++ +K+HQ + + F +LEI R++D YG + H A D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKR+RFL+KLHPE V G Y+D LEF SR++CK FWK C+E+H+FFR
Sbjct: 54 VLLLDSSTLPLEIGPKTTGQALLSQLFTHLNVVETDYFGIEFQTAQAQWVWLEPLKSVNKQLRKPKNAKLRLAVKFFPPDPGQLQEEYTRYLFALQIKRDLEEEKLVCFDSTTALLISLLLQSEIGDYDQKVVQDHLQNTYYVQRQHSLE----DRIMKYHQQHIGMSPGDADFQILEIARRLDLYGTRFHLASDREGAKINLSVSHMGVLVFQGSTKINTFNWSKIRKLSFKRRRFLIKLHPE----------VHGPYQDALEFLLPSRDTCKRFWKICVEYHSFFR 327
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Xenopus
Match: pdcd6ip (programmed cell death 6 interacting protein [Source:Xenbase;Acc:XB-GENE-1194420]) HSP 1 Score: 214.157 bits (544), Expect = 9.361e-58 Identity = 106/288 (36.81%), Postives = 165/288 (57.29%), Query Frame = 2
Query: 194 VKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
V LD + + G L ++ + ++E+ +FG+++ + + WL+ K + KQ + VKF+ PDP L + T+ LF LQ+K+D+ +L+C +ST LL L ++ + + ++ + Q ++ +L ++ +K+HQ + + F +LEI R++D YG + H A D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKR+RFL+KLHPE V G Y+D LEF SR++CK FWK C+E+H+FFR
Sbjct: 54 VLLLDSSTLPLEIGPKTTGQALLSQLFTHLNVVETDYFGIEFQTAQAQWVWLEPLKSVNKQLRKPKNAKLRLAVKFFPPDPGQLQEEYTRYLFALQIKRDLEEEKLVCFDSTTALLISLLLQSEIGDYDQKVVQDHLQNTYYVQRQHSLE----DRIMKYHQQHIGMSPGDADFQILEIARRLDLYGTRFHLASDREGAKINLSVSHMGVLVFQGSTKINTFNWSKIRKLSFKRRRFLIKLHPE----------VHGPYQDALEFLLPSRDTCKRFWKICVEYHSFFR 327
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Xenopus
Match: pdcd6ip (programmed cell death 6 interacting protein [Source:Xenbase;Acc:XB-GENE-1194420]) HSP 1 Score: 215.312 bits (547), Expect = 1.226e-57 Identity = 106/288 (36.81%), Postives = 165/288 (57.29%), Query Frame = 2
Query: 194 VKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
V LD + + G L ++ + ++E+ +FG+++ + + WL+ K + KQ + VKF+ PDP L + T+ LF LQ+K+D+ +L+C +ST LL L ++ + + ++ + Q ++ +L ++ +K+HQ + + F +LEI R++D YG + H A D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKR+RFL+KLHPE V G Y+D LEF SR++CK FWK C+E+H+FFR
Sbjct: 54 VLLLDSSTLPLEIGPKTTGQALLSQLFTHLNVVETDYFGIEFQTAQAQWVWLEPLKSVNKQLRKPKNAKLRLAVKFFPPDPGQLQEEYTRYLFALQIKRDLEEEKLVCFDSTTALLISLLLQSEIGDYDQKVVQDHLQNTYYVQRQHSLE----DRIMKYHQQHIGMSPGDADFQILEIARRLDLYGTRFHLASDREGAKINLSVSHMGVLVFQGSTKINTFNWSKIRKLSFKRRRFLIKLHPE----------VHGPYQDALEFLLPSRDTCKRFWKICVEYHSFFR 327
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Mouse
Match: Farp2 (FERM, RhoGEF and pleckstrin domain protein 2 [Source:MGI Symbol;Acc:MGI:2385126]) HSP 1 Score: 237.654 bits (605), Expect = 1.158e-64 Identity = 127/294 (43.20%), Postives = 176/294 (59.86%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+VK LD VE F + G L ++ + LIE +FGL++ ++ S WL+ K I +Q + VKF+ PDP L + T+ LF LQLK+D+ L C+ +T LL ++ + + +E LD + HL ++ L ++ +E+ L FHQ QT E+ F +LEI RK++ YG++ H A D EG +NLAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 MRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPMKPIIRQVRKPKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCTANTAALLISHLLQSEIGDYDET-LDRE-----HLKANEYLPNQEKSLEKILDFHQRHTGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Mouse
Match: Farp2 (FERM, RhoGEF and pleckstrin domain protein 2 [Source:MGI Symbol;Acc:MGI:2385126]) HSP 1 Score: 234.958 bits (598), Expect = 1.630e-62 Identity = 127/294 (43.20%), Postives = 176/294 (59.86%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+VK LD VE F + G L ++ + LIE +FGL++ ++ S WL+ K I +Q + VKF+ PDP L + T+ LF LQLK+D+ L C+ +T LL ++ + + +E LD + HL ++ L ++ +E+ L FHQ QT E+ F +LEI RK++ YG++ H A D EG +NLAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 MRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPMKPIIRQVRKPKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCTANTAALLISHLLQSEIGDYDE-TLDRE-----HLKANEYLPNQEKSLEKILDFHQRHTGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321 HSP 2 Score: 108.612 bits (270), Expect = 3.618e-23 Identity = 89/323 (27.55%), Postives = 150/323 (46.44%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIK------------SRLNHSPQEIV---SKINSPNQTKF-WTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
E+ +++++L+ + N+++LT + + ++ L EF IR G L KL+ KG R+F L D L+ + K + R FL +R + E + N + V TI + ++ + A T + W++D+ A A+ TI +R S E+ S+ N+ ++R + +CW+ S+S+ LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P DSI K +V KL+ + F R E++Y + RW
Sbjct: 721 EVTTELQQSLTRLENLQKLTELQRDLVGVENLIAPGR-EF--------IREGCLHKLTKKGLQQRMFFLFSDMLLYTSKSVTGASHFRIRGFLP-LRGMLVEE---SENEWSVPHC----FTIYA--------AQKTIVVAASTRLEKEKWMQDLNAAIQAAKTIGDSPPVLLGGPVYTRTPRSSDEVSLEESEDGRGNRGSLEGNSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKLQFKSHVYFFRAESKYTFERW 1018
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Mouse
Match: Frmd7 (FERM domain containing 7 [Source:MGI Symbol;Acc:MGI:2686379]) HSP 1 Score: 218.394 bits (555), Expect = 7.059e-59 Identity = 118/295 (40.00%), Postives = 174/295 (58.98%), Query Frame = 2
Query: 179 LINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++KV++LDD + F +++ S G LF + L E +FGL++ S + WL+L K I KQ E+ ++ VKF+ DP L + LT+ LF LQ+KKD+ G L CS++ L+ ++ + + E E HL Q L S+ + ++FHQ ++ E+ LL+I RK+D YG++ PA D EG+ ++LAV HMG+++ + TKINTFNW+KIRKLSFKRK FL+KLH + VL KDTLEF SR++CK FWK C+E+H FFR
Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHE------ETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLH----ANILVLC------KDTLEFTMASRDACKAFWKTCVEYHAFFR 279
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Mouse
Match: Farp1 (FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) [Source:MGI Symbol;Acc:MGI:2446173]) HSP 1 Score: 219.935 bits (559), Expect = 9.864e-58 Identity = 120/296 (40.54%), Postives = 180/296 (60.81%), Query Frame = 2
Query: 170 SGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
SG L+ +K++ LDD E F + + + G LF + + L+E +FGL++ + WLDL K I KQ + + VKF+ PD L + LT+ LF LQ+K+D+ G L C++++ LL ++ + + +E LD +E + + Q + E ++ ++FH + QT E+ F LLE+ R+++ YG++LHPAKD EG +NLAV + GI++FQ +TKIN FNW+K+RKLSFKRKRFL+KL P+ V Y+DTLEF R+ CK+FWK C+EHH FFR
Sbjct: 36 SGKLMTVKIQMLDDTQEAFEVPQRAPGKVLFDAVCNHLNLVEGDYFGLEFPDHRKIVVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDE-ALD-REHLAKNKYVPQQDALE--DRIMEFHHSHVGQTPAESDFQLLEVARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPD----------VNSSYQDTLEFLMAGRDFCKSFWKICVEHHAFFR 317 HSP 2 Score: 97.8265 bits (242), Expect = 8.469e-20 Identity = 90/336 (26.79%), Postives = 147/336 (43.75%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIR---------NAASASITIKSRL-NHSPQEIVSKIN------SPNQTKFWTEKYR----LIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
E++ Q+ T+ + N ++L + + I L T EF IR+G L KLS KG R+F L D L+ + + L S +++ G E ++ G + L G R S+ + A + W+EDI+ N + + S N SP E + S ++T + ++ +CWH S+S LS +LRK+K+SN WQ+LWVV ++ LFFY++H +ASL L+G+ ++ P+ ++I K +V KL + + R E+EY + RW + T S S
Sbjct: 725 EMVAQLHGTMIKMENFQKLHELKKDLIGIDNLV-TPGREF--------IRLGSLSKLSGKGLQQRMFFLFNDVLLYTSR--GLTASNQFKVHGQLPLYGMTIEESEEEWG----------VPHCLTLRGQR----QSIIVAASSRSEMEKWMEDIQMAIDLAEKSNGPTPELLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRSTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDSHPLASLPLLGYSLTIPSESENIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSAS 1035
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Mouse
Match: Epb41l1 (erythrocyte membrane protein band 4.1 like 1 [Source:MGI Symbol;Acc:MGI:103010]) HSP 1 Score: 169.088 bits (427), Expect = 1.437e-42 Identity = 103/293 (35.15%), Postives = 150/293 (51.19%), Query Frame = 2
Query: 191 KVKYLD-DHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQ---FLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+V LD EC + ++ G LF + + L+E +FGL Y DS WLD K IKKQ + + VKFY PDP L +++T+ LQL+ DI G L CS T LLG + ++E D +E ++ L N + E E+ ++ H+T + T E LE +K+ YG+ LH AKD+EG+ + L V G++I++ +IN F W KI K+S+KR F +K+ P EY + ++ T+ F + S K WK CIEHHTFFR
Sbjct: 100 RVTLLDASEYEC-EVEKHGRGQVLFDLVCEHLNLLEKDYFGLTYCDADSQKNWLDPSKEIKKQI-RSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAV-----QAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQ----------FESTIGFKLPNHRSAKRLWKVCIEHHTFFR 375
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q91VS8|FARP2_MOUSE (FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Mus musculus OX=10090 GN=Farp2 PE=1 SV=2) HSP 1 Score: 234.958 bits (598), Expect = 1.140e-61 Identity = 127/294 (43.20%), Postives = 176/294 (59.86%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+VK LD VE F + G L ++ + LIE +FGL++ ++ S WL+ K I +Q + VKF+ PDP L + T+ LF LQLK+D+ L C+ +T LL ++ + + +E LD + HL ++ L ++ +E+ L FHQ QT E+ F +LEI RK++ YG++ H A D EG +NLAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 MRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPMKPIIRQVRKPKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCTANTAALLISHLLQSEIGDYDE-TLDRE-----HLKANEYLPNQEKSLEKILDFHQRHTGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321 HSP 2 Score: 108.612 bits (270), Expect = 2.531e-22 Identity = 89/323 (27.55%), Postives = 150/323 (46.44%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIK------------SRLNHSPQEIV---SKINSPNQTKF-WTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
E+ +++++L+ + N+++LT + + ++ L EF IR G L KL+ KG R+F L D L+ + K + R FL +R + E + N + V TI + ++ + A T + W++D+ A A+ TI +R S E+ S+ N+ ++R + +CW+ S+S+ LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P DSI K +V KL+ + F R E++Y + RW
Sbjct: 721 EVTTELQQSLTRLENLQKLTELQRDLVGVENLIAPGR-EF--------IREGCLHKLTKKGLQQRMFFLFSDMLLYTSKSVTGASHFRIRGFLP-LRGMLVEE---SENEWSVPHC----FTIYA--------AQKTIVVAASTRLEKEKWMQDLNAAIQAAKTIGDSPPVLLGGPVYTRTPRSSDEVSLEESEDGRGNRGSLEGNSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKLQFKSHVYFFRAESKYTFERW 1018
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|O94887|FARP2_HUMAN (FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FARP2 PE=1 SV=3) HSP 1 Score: 234.958 bits (598), Expect = 1.191e-61 Identity = 123/294 (41.84%), Postives = 179/294 (60.88%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++VK LD+ +E F + G L ++ R+ L+E +FG+++ + S WL+ K I +Q + + VKF+ PDP L + T+ LF LQLK+D+ L C+++T LL ++ + + +E LD + HL ++ L + +E+ L+FHQ QT E+ F +LEI RK++ YG++ H A D EG + LAV HMG+++FQ TKINTFNWSK+RKLSFKRKRFL+KLHPE V G Y+DTLEF SR+ CKNFWK C+E+HTFFR
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDE-TLDRE-----HLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPE----------VHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321 HSP 2 Score: 98.9821 bits (245), Expect = 2.129e-19 Identity = 86/325 (26.46%), Postives = 145/325 (44.62%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASI------------TIKSRLNHSPQEIVSKINSPNQTKF------WTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
E+ ++ L + N+++LT + + I+ L EF IR G L KL+ KG R+F L D L+ + K + R L G + E ++ N + V TI + ++ + A T + W+ D+ +A A+ T+ +R SP E+ + S + + ++R + +CW+ S+S+ LS Y+LRK+K+S+ WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P D I K +V KL+ + F R E++Y + RW
Sbjct: 718 EVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGR-EF--------IREGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLP--LQGMLVE--ESDNEWSVP----HCFTIYA--------AQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERW 1017
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|F1LYQ8|FARP1_RAT (FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Rattus norvegicus OX=10116 GN=Farp1 PE=1 SV=2) HSP 1 Score: 233.417 bits (594), Expect = 3.046e-61 Identity = 120/296 (40.54%), Postives = 180/296 (60.81%), Query Frame = 2
Query: 170 SGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
SG L+ +K++ LDD E F + + + G LF + + L+E +FGL++ + WLDL K I KQ + + VKF+ PD L + LT+ LF LQ+K+D+ G L C++++ LL ++ + + +E LD +E + + Q + E ++ ++FH + QT E+ F LLE+ R+++ YG++LHPAKD EG +NLAV + GI++FQ +TKIN FNW+K+RKLSFKRKRFL+KL P+ V Y+DTLEF R+ CK+FWK C+EHH FFR
Sbjct: 36 SGKLMTVKIQMLDDTQEAFEVPQRAPGKVLFDAVCNHLNLVEGDYFGLEFPDHRKIVVWLDLLKPIVKQIRRPKHVLVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDE-ALD-REHLAKNKYVPQQDALE--DKIVEFHHSHIGQTPAESDFQLLEVARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPD----------VNSSYQDTLEFLMAGRDFCKSFWKICVEHHAFFR 317 HSP 2 Score: 97.4413 bits (241), Expect = 8.115e-19 Identity = 89/339 (26.25%), Postives = 149/339 (43.95%), Query Frame = 2
Query: 2408 CQEIIVQIKETLS-LVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIR---------NAASASITIKSRL-NHSPQEIVSKIN------SPNQTKFWTEKYR----LIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
C+ + +I E ++ L G + ++ + + + K L I+ I IR+G L KLS KG R+F L D L+ + + L S +++ G E ++ G + L G R S+ + A + W+EDI+ N + + S N SP E + S ++T + ++ +CWH S+S LS +LRK+K+SN WQ+LWVV ++ LFFY++H +ASL L+G+ ++ P+ ++I K +V KL + + R E+EY + RW + T S S
Sbjct: 717 CRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIG---IDNLVIPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSR--GLTASNQFKVHGQLPLYGMTIEESEEEWG----------VPHCLTLRGQR----QSIIVAASSRSEMEKWLEDIQMAIDLAEKSNGPTPELLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRSTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDSHPLASLPLLGYSLTIPSESENIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSAS 1036
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|A2AD83|FRMD7_MOUSE (FERM domain-containing protein 7 OS=Mus musculus OX=10090 GN=Frmd7 PE=1 SV=1) HSP 1 Score: 218.394 bits (555), Expect = 4.938e-58 Identity = 118/295 (40.00%), Postives = 174/295 (58.98%), Query Frame = 2
Query: 179 LINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++KV++LDD + F +++ S G LF + L E +FGL++ S + WL+L K I KQ E+ ++ VKF+ DP L + LT+ LF LQ+KKD+ G L CS++ L+ ++ + + E E HL Q L S+ + ++FHQ ++ E+ LL+I RK+D YG++ PA D EG+ ++LAV HMG+++ + TKINTFNW+KIRKLSFKRK FL+KLH + VL KDTLEF SR++CK FWK C+E+H FFR
Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHE------ETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLH----ANILVLC------KDTLEFTMASRDACKAFWKTCVEYHAFFR 279
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q6ZUT3|FRMD7_HUMAN (FERM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=FRMD7 PE=1 SV=1) HSP 1 Score: 215.698 bits (548), Expect = 4.133e-57 Identity = 120/298 (40.27%), Postives = 177/298 (59.40%), Query Frame = 2
Query: 179 LINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLK-----FHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
++++KV++LDD + F +++ S G LF + L E +FGL++ S + WL+L K I KQ E+ ++ VKF+ DP L + LT+ LF LQ+KKD+ G L CS++ L+ ++ + + E + D K HL + L ++ CL+ FHQ ++ E+ LL+I RK+D YG++ HPA D EG+ ++LAV HMG+++ + TKINTFNW+KIRKLSFKRK FL+KLH + VL KDTLEF SR++CK FWK C+E+H FFR
Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHE-ETDRK-----HLAQTRYLPNQ---DCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLH----ANILVLC------KDTLEFTMASRDACKAFWKTCVEYHAFFR 279
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. TrEMBL
Match: A0A2R5L889 (Putative rho guanine nucleotide exchange factor cdep (Fragment) OS=Ornithodoros turicata OX=34597 PE=4 SV=1) HSP 1 Score: 332.798 bits (852), Expect = 6.630e-92 Identity = 312/1085 (28.76%), Postives = 488/1085 (44.98%), Query Frame = 2
Query: 242 SLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEIC--VKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPN-------PSFLRLSRRNSENKYKSNHSL--SVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDN-----HCLQFGNHTAVNLTADGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEII---FKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEH--IDKFLAIMNDYHFQIEHNLKCYIEEIKTFIYALNQCEYSSDCFDKF--QFENDGESETNFLRLLLSPIIQQRAHXXXXXXXXXXXXXDEEEKQICQEIIVQIKETLSL-VGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKK--IPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRN--AASASITIKS-RLN-------HSPQEIVSKINSPNQTKFWTEKYR--------LIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALS 3340
+ G LF ++ + L+E +FGL+Y WLD K + +Q + ++ +C VKFYTPDP L + T+ LF LQ+KKD++ G L CS+ST LL G F+ YP+ L +F+ H D L + +E H+ Q+ E +LLE R+ + YG+++ PAKDNEGL+LNL+V HMGI++FQ YTKINTF+WSKIRKLSFKRK+FL+KLHPE Y G+YK+ ++++FESRN CKNFWKKCIE+H+FFR + +K + R GS FRY G TQ ++ + +E Y FQRS S RL S + PS L +S S + + S P P + + N D H Q L DN + L+ G+ +A T G S + E P L + SSA N +P++ PE S D + ++ D + VP Q S S + + N A + I K+L+ Y K LE+I FK E +D + + + +L+ I S+L LEQ + L P + I ++ DY I Y+E++ + L + + F++ +FE E LL P + + L S+ + C +I+ +++++ SL ++ +L + V++M + L + N IR G LQKLS KG R+F L D L+ + + P L F V + L + V A+ A + + + + ++ + A + + R W++ + + AA+ S ++K RL+ HS E + +++ Q R + +CWH S+ + + R LS ++LRK+K+S+ WQ+LWVV ++ LFFY+++ +ASL L+G+ ++ P D+I+K +V KL+ + F R E+EY + RW +S
Sbjct: 2 ATGRVLFDQVCRVINLLEVDYFGLEYTDSSGTKYWLDYDKPLCRQMGL-SMVSPVMCFAVKFYTPDPAQLEEEFTRYLFSLQIKKDLSLGILQCSDSTAALLASYIVQASCGDFVTEDYPDHSYLS---SYKFVPH--QDAELEIKIMEN----HKKHVSQSPAEADLNLLETARRCELYGIRMTPAKDNEGLALNLSVAHMGIIVFQNYTKINTFSWSKIRKLSFKRKKFLIKLHPEGY----------GYYKEMVDYFFESRNECKNFWKKCIENHSFFR-------CTEVKKIPRQKTRLFSRGSSFRYSGRTQKQIVEYVRENYVKRQPFQRSTSL-RLPSRSNVETPAVPSLLPVSSSRSCGSVAMSFEVPASEPSAPPMLTAVSEPNSPRRDS-------ARHPQEGPLTPSQDTDDNISHDSYRLEEGDSSAAPHTEPG-----SPITIELHAPPPPPPCLRTGQSHESSAEVHNGGLPVAHSMSPEAPQSPDLSYSFRHDASGQGGAD--SSVPASPQQESCSDVRR-KKYPNEKAYF---------------------------------ITKELVMTERTYKKHLEVILLYFKEKVEKEDADNVPAEALAILFSSLDPIYKVCISLLRDLEQRLAAWEGKLA-PGSYCNIHGIGGLLLDY-CHITELYDHYLEKLPRVLEDLQGSCHHNPYFERLYREFERQKECYLPLALFLLHPAHRLLHYCQLLQRLHESYDSNHADNVACLDILQRLRKSTSLHKESLCKLENFVMLMELQHDLIGVDNL---MQPGRNFIREGCLQKLSRKGYQQRMFFLFSDVLIYASRASTPQLQFKVHGQLPLQSLSVDETEPKAEAAFRFNIYA------------------ANRALMVAASSEEERQKWMKALSDSIAAACSCSLKDERLHYSSLKSCHSSDERLDRLSQEGQQSPGGAAERHVQHRSNTAVHVCWHRNTSVGRDDHKKAHRNYLSGFLLRKFKNSSGWQKLWVVFTNFCLFFYKSYHESSPLASLPLVGYTVTLPGPNDNINKDFVFKLQFKTHVYFFRAESEYAFARWVEVIS 987
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. TrEMBL
Match: A0A1X7RBN3 (FERM domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=frm-3 PE=1 SV=1) HSP 1 Score: 288.115 bits (736), Expect = 2.153e-76 Identity = 287/1110 (25.86%), Postives = 495/1110 (44.59%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQ-TDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQ--------YPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQ--KHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHC---LQFGNHTAVNLTADGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVN--NSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSD----------SFNCDKSTCLPSDSTEVI-------SYQTILQSIEKDLLFNGFMYLKELEIIFK-ILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNL----KCYIEEIKTFIYALNQCEYSSDCF----DKFQFENDGESETNFLRL-LLSPIIQQRAHXXXXXXXXXXXXXDEEEKQ----ICQEIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLN---FSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIED----IRNAASASITIKSRLNHSPQE---IVSKINSPNQTKFWTEKYRLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCH-LFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSW-VIKLEKELKTCFLRIENEYFYHRW 3325
G L+ IKV+ LDD V F + ++G L ++ + L+E +FGL ++ ++ + CWLD K I +Q T+ + + VKFYTP+P L + T+ LF +Q+K+D+ GEL CS++T LL ++ + YP++ +L H N + EF ++ + H+ T E+ +LE+ R+ DFYG+KLH AKD +G L+V H+GI +F++ TF+W++IRKLSFKRK+ LVKLHP+ Y + K+T+EF FE+R+ CKNFWKKC+EHH FFR C+++ + K GS FRY G TQ +L +E ++ F R LR + + Y S + L N V E + N + N H + + +H +Q + +VN D + +ST S+E + + K NK + + S D E+N NS D + SI D A + L + S + ++ ++T+ S D PS S+E + L ++ K+ + +Y K++ +I + ++ KD V + C+ K + +L E+ + +++ L + E D A++ HNL + ++ ++ AL+Q S F KF+ + ++ N++ L +L+ +I + ++ + L ++ E +II K+T + ++EE H VL + GL +I +R+G++ + + + R+ +L D+++ + +L+ F+V + L + M + Y+V + IT+ D S+ A R+ WIED I+NAA A I + S + +E ++K+ P ++ K + ICW+ + S ++ + ++ Y+ RK ++S+ WQ LWVV+ CH L+FY+NH ++ +A L L+ + + P + D I KL T F R ++ YF+ RW
Sbjct: 34 GRLVCIKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGLSFIDINGNHCWLDREKTILRQITNGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLALGELHCSDNTASLLSAYLVQSECGDFSSEDYPDA---------TYLSHTRFVPNQTLEFQKKVMDNHRNFIGMTPGESDLAMLEVARRCDFYGVKLHAAKDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFKRKKLLVKLHPDSY----------QYLKETVEFSFETRDECKNFWKKCVEHHAFFR---------CVQAEEPKKETRFFISKGSSFRYHGRTQKQLIDYVREHHKRREPFTRP-------------LRSAASTRKGTYSSTYGLVTDRPTKHRNGSVYEPNQTDPYNKHQ---NTHSSMPHIAHISSQPADHSFSDIQEPLYQSVNKKKDVIVGINSTFSSE---TICTSEPILKVNK------KPRKRMSRSANDTSELNKYNSSD--------SGGLSIGDPTAGSNDSLRLMKRDHSSDYQLRHDYAVMRTSQSTASVGTPSKEIEMSLENDVDNYPPSCSSEYYITRKDFGKPEPQLANVLKEFYWKELVYSKDMRLINESFFNKIKDDV-VDCRFLKELFGSLKELPPIHQPLIDALRE----------SSNEPEDSKAAMVAPVLLATVHNLTPLYQSLVQNFPIYVSALDQLYRSKIPFRTIMSKFESSKECYTQVNWILLKILNRLINWQPVLARVIEIQLSECGNDTETTAFGVAMDKIIEFAKKTKATRQSLEEYIH-VLQVERDTGLVGILTHPNRKI-----LRVGFVLRSARRAPCCRIMVLCSDRILFGHRGVNLDGNFFTVHAEFKLKGM-------MIDEGDTYKVMDGENNVITLHNAD--------ISIVFAA---PDRASWIEDITEAIKNAARAKIDLPSLVMEKKEENDIDMTKVLLPEESP--VSKMSPLQICWYRKCSFGRKDVNKMITNTMCGYLKRKLRNSSGWQDLWVVMC-CHTLYFYRNHNEREPLAHLSLMDYGVGLPTVADKIDNHENCFKLFYGSHTYFFRTDSYYFFERW 1044
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. TrEMBL
Match: A0A1B6KVY3 (Uncharacterized protein (Fragment) OS=Graphocephala atropunctata OX=36148 GN=g.27034 PE=4 SV=1) HSP 1 Score: 276.944 bits (707), Expect = 1.248e-75 Identity = 154/365 (42.19%), Postives = 217/365 (59.45%), Query Frame = 2
Query: 164 ENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYK--NELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSES 1228
+ G ++ I+V+ LDD V F + ++G LF ++ ++ L+E+ +FGL+Y WLDL K + +Q + L Y CVKFYTPDP L + T+ LF LQ+K+D++ G + C+E+T L+ G F+ YP++ L +F+ H D++L +E H+ Q+ E +LLE R+ + YGMK+HPAKD+EG+ LNL+V HMGIV+FQ YTKINTF+W+KIRK+SFKRKRFL+KLHPE Y G+YKDT+EF+FE RN CKNFWKKC+E+H FFR S +K + R GS FRY G TQ ++ + +E Y FQRS+S
Sbjct: 44 KKGGKMLAIRVQMLDDSVTMFQVQAKAVGRVLFDQVCKQLHLLEADYFGLEYQDSSGTRYWLDLEKPLARQVGLTLVDPLLY-FCVKFYTPDPAQLEEEFTRYLFCLQIKRDLSQGHIQCNENTAALMASYIVQAECGDFVTEDYPDASYLS---TYKFVPH--QDRDLERRIMEN----HKKHAGQSPAEADLNLLETARRCELYGMKMHPAKDHEGVPLNLSVAHMGIVVFQNYTKINTFSWAKIRKISFKRKRFLIKLHPEGY----------GYYKDTVEFFFEGRNECKNFWKKCVENHGFFR-------CSTVKKVPRQRTRVLSRGSSFRYSGKTQKQMVEFVRENYVKRQTFQRSQS 381
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. TrEMBL
Match: A0A1B6JG50 (FERM domain-containing protein (Fragment) OS=Homalodisca liturata OX=320908 GN=g.29040 PE=4 SV=1) HSP 1 Score: 263.077 bits (671), Expect = 9.193e-75 Identity = 135/308 (43.83%), Postives = 192/308 (62.34%), Query Frame = 2
Query: 164 ENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYK--NELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLG--------GLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ G ++ I+V+ LDD + F + ++G LF ++ ++ L+E+ +FGL+Y WLDL K + +Q + L Y CVKFYTPDP L + T+ LF LQ+K+D++ G + C+E+T L+ G F+ YP++ L +F+ H D++L +E H+ Q+ E +LLE R+ + YGMK+HPAKD+EG+ LNL+V HMGIV+FQ YTKINTF+W+KIRK+SFKRKRFL+KLHPE Y G+YKDT+EF+FE RN CKNFWKKC+E+H FFR
Sbjct: 44 KKGGKMLAIRVQMLDDSITMFQVQAKAVGRVLFDQVCKQLHLLEADYFGLEYQDSSGTRYWLDLEKPLARQVGLTLVDPLLY-FCVKFYTPDPAQLEEEFTRYLFCLQIKRDLSQGHIQCNENTAALMASYIVQAECGDFVAEDYPDASYLS---TYKFVPH--QDRDLERRIMEN----HKKHAGQSPAEADLNLLETARRCELYGMKMHPAKDHEGVPLNLSVAHMGIVVFQNYTKINTFSWAKIRKISFKRKRFLIKLHPEGY----------GYYKDTVEFFFEGRNECKNFWKKCVENHGFFR 331
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. TrEMBL
Match: A0A267E349 (FERM domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig022379g3 PE=4 SV=1) HSP 1 Score: 264.618 bits (675), Expect = 5.155e-74 Identity = 150/375 (40.00%), Postives = 218/375 (58.13%), Query Frame = 2
Query: 164 ENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFN------DQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGR-LASPNPSFLR 1267
+SG + +KV LDD V F + G +LF + +++L+E +F L+++S D WL+ K + KQ EL + VKFY PDP+LL D T+ LF LQ+K+D+ NG L CSE+T LL ++ E+ +++++L L+ Q + E + + +++H+ T + + LL+ RK++ YG++LHPA+D+EGL LNLAV H G+++FQ +INTF+W+KIRKLSFKRK+FLVKLHPE Y ++KD +EFYF+SR+ CK+FWKKCIEHHTFFR +K K + GS FRY G TQ +L + +E Y F RS S R L S +P+ R
Sbjct: 14 RSSGKTLTVKVVLLDDTVNSFQVPARLPGQELFNAVVKKLKLLEVDYFDLEFLSRDGRQSWLEHEKTLPKQCPSTAELIFYFSVKFYPPDPHLLEDEFTRFLFALQIKRDLLNGLLPCSENTLALLASYLVQ------AEIGDFLEDEYLDTLYLTQLKVLPQPYTDELLFKVMEYHKAHLGLTPEDAEYSLLDTARKVELYGIRLHPARDHEGLPLNLAVAHAGVLVFQGTARINTFSWAKIRKLSFKRKKFLVKLHPEGY----------NYFKDVVEFYFDSRDECKHFWKKCIEHHTFFR-------CQGVKQAGKSRSKVVSKGSSFRYCGRTQKQLIEFVRENYVKRPQFDRSSSGARSLPSRSPAARR 365
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Cavefish
Match: si:ch211-243g6.3 (FERM domain-containing protein 7-like [Source:NCBI gene;Acc:103043485]) HSP 1 Score: 233.417 bits (594), Expect = 5.390e-64 Identity = 117/296 (39.53%), Postives = 183/296 (61.82%), Query Frame = 2
Query: 176 GLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSS-EFIE-QCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
G ++V +LDD F + + LG D F K+ ++L+E +FGL++ + WL+L K + KQ + ++LA++ VKF+ PDP L LT+ LF LQ+K+D++NG L C++++ LL ++ + + +E +LD HL N Q + + E+++ + ++FH+ + T ++ LLE+ RK+D YG++ HPA D EG+ +NLAV HMG+++FQ TKINTF+W+KIRKLSFKR+ FL+KLH E +D +EF SR+ CK FWK C+E+H FFR
Sbjct: 21 GRARLRVIFLDDSERVFEVEQKILGCDFFNKVCGHLKLLEKEYFGLEFRHHNGSYVWLELLKPLAKQIKHTSDLAFQFIVKFFPPDPGQLQKGLTRYLFALQIKQDLSNGSLTCNDNSAALLVSHILQAEIGDYDE-ELDAH-----HLENKQYVPNQEYLDHKIIRFHKKHRGHTPAQSDVHLLEVARKLDMYGIRPHPAHDGEGMRINLAVTHMGVLVFQGNTKINTFSWAKIRKLSFKRRHFLIKLHTE----------AGPSRRDMVEFTMASRDICKTFWKMCVEYHAFFR 300
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Cavefish
Match: FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1 [Source:NCBI gene;Acc:103041913]) HSP 1 Score: 238.039 bits (606), Expect = 9.348e-64 Identity = 122/298 (40.94%), Postives = 177/298 (59.40%), Query Frame = 2
Query: 170 SGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
SG + I+V+ LD+ E F +++ + G LF + + LIE +FGL+Y WLDL K I KQ VKF+ PD L + LT+ LF LQ+++D+ G L C++S+ LL I+ + + EE Q HL N+ + + +++ ++FHQ QT E+ + LLE+ R+++ YG++LHPAKD EG L+L+V H G+++FQ +TKIN FNWSK+RKLSFKRKRFL+KL P+ + Q Y+DTLEF SR+ CK FWK C+E+H FFR
Sbjct: 36 SGRHVPIRVRMLDESEEIFDISQRASGKVLFDLVCAHLNLIEGDYFGLEYQDQRKMTVWLDLLKPIMKQLRRPKHTVLRFVVKFFPPDHAQLMEELTRYLFALQIRQDLATGRLTCTDSSAALLVSHIIQSEIGDYEEAQCRQ------HLLNNNYIPDQMALMDKIMEFHQKHVGQTPAESDYQLLEVARRLEMYGIRLHPAKDREGTKLSLSVAHTGVLVFQGHTKINAFNWSKVRKLSFKRKRFLIKLRPD---------LNQSAYQDTLEFVMASRDCCKVFWKICVEYHAFFR 318 HSP 2 Score: 113.235 bits (282), Expect = 1.008e-24 Identity = 85/298 (28.52%), Postives = 136/298 (45.64%), Query Frame = 2
Query: 2558 IRIGWLQKLSNKGASNRLFILLPDQLV-CSKKIPSLN-FSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIR---------NAASASITIKSRLNHSPQEIVSKINSPNQ---TKFWTEKY----------RLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS*ISFQN 3379
IR+G L KLS KG R+F L D L+ S+ I S N F V + L + + E + + + + SV + AG++ W+ED++ N SAS+ S SP E S++ S + ++ E++ + +CWH S+S LS +LRK+K+SN WQ+LWVV ++ LFFY+ H + +ASL L+G+ ++ P ++I K +V KL + + R E+EY + RW + T S+S + N
Sbjct: 734 IRLGCLSKLSGKGLQQRMFFLFSDVLLYTSRGITSSNQFKVHGQLPLRGMTIRESEEEWGVPHCFTLVTQ------------------RQSVVVAAGSVSEMEKWMEDLKMAVDLAEDSNGPSASLLTNSNDVKSPGEWASEVESEDDLGGSRTSLERHGNSSAHHRGNTTVHVCWHRNTSVSMLDFSIATENQLSGNLLRKFKNSNGWQKLWVVFTNFSLFFYKTHQDEYPLASLPLLGYSVTVPAESENIHKDYVFKLHFKSHIYYFRSESEYSFERWMEVIRSATISSSRTRYLN 1013
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Cavefish
Match: farp2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:NCBI gene;Acc:103028790]) HSP 1 Score: 236.884 bits (603), Expect = 1.582e-63 Identity = 119/292 (40.75%), Postives = 176/292 (60.27%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+V+ LDD E F + + G + + R+ LIES +FGL++ +L + WL+ K+I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ G L C+E+T LL ++ + + +E + ++ + L ++ ++ H+ QT E+ F +LEI RK++ YG++ HPA D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKRKRFL+KLHP+ V G ++DTLEF SR+ CK FWK C+EHH+FFR
Sbjct: 50 LQIRVQGLDDAQEFFDLESKADGQTVLTDVYRRINLIESDYFGLEFQNLQMNWVWLEPTKLIVKQVRRPVNTLFRLSVKFFPPDPGQLQEEFTRYLFSLQMKRDLMEGRLYCTENTAALLASHLVQSEIGDYDE----VADREFLKLNKLLPHQEHLQDKIMELHRRHLGQTPAESDFQVLEIARKLEMYGIRFHPAADREGTKINLSVAHMGLLVFQGNTKINTFNWSKIRKLSFKRKRFLIKLHPD----------VHGPHRDTLEFLMASRDQCKIFWKSCVEHHSFFR 327
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Cavefish
Match: farp2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:NCBI gene;Acc:103028790]) HSP 1 Score: 237.269 bits (604), Expect = 2.221e-63 Identity = 119/292 (40.75%), Postives = 176/292 (60.27%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+V+ LDD E F + + G + + R+ LIES +FGL++ +L + WL+ K+I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ G L C+E+T LL ++ + + +E + ++ + L ++ ++ H+ QT E+ F +LEI RK++ YG++ HPA D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKRKRFL+KLHP+ V G ++DTLEF SR+ CK FWK C+EHH+FFR
Sbjct: 50 LQIRVQGLDDAQEFFDLESKADGQTVLTDVYRRINLIESDYFGLEFQNLQMNWVWLEPTKLIVKQVRRPVNTLFRLSVKFFPPDPGQLQEEFTRYLFSLQMKRDLMEGRLYCTENTAALLASHLVQSEIGDYDE----VADREFLKLNKLLPHQEHLQDKIMELHRRHLGQTPAESDFQVLEIARKLEMYGIRFHPAADREGTKINLSVAHMGLLVFQGNTKINTFNWSKIRKLSFKRKRFLIKLHPD----------VHGPHRDTLEFLMASRDQCKIFWKSCVEHHSFFR 327 HSP 2 Score: 105.145 bits (261), Expect = 3.109e-22 Identity = 95/328 (28.96%), Postives = 148/328 (45.12%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLV-CSKKIPSLN-FSVEYRWFLSD-IRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASAS------------ITIKSRLNHSPQEIV------SKINSPNQTKFWTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
EI Q++ +L + N ++LT + + I+ L EF IR G L KL+ KG R+F L D L+ SK + + N F V + L I + + + ++ N + V TI + ++ + A + + WIED+ A S ++ R N S E+ +NS + +R + +CWH S+S LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P DSI K +V KL+ + F R E+EY + RW
Sbjct: 727 EIAAQLQSSLIRLENFQKLTELQRDLIGIENL-TAPGREF--------IREGCLYKLTKKGLQQRMFFLFSDMLLYTSKGVTATNQFKVHGQLPLHGMILIVLDAPVEESENEWSVPHC----FTIY--------SAQRTIVVAASSKLEMTKWIEDLNMAIDMSKKSQEKSDLLLDPSLCDRSNRSSDEVSLEQESEDDVNSSRCSLDKQSHHRANTTMHVCWHRNTSVSMSDHSLAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVSTPGEADSIHKEYVFKLQFKSHVYFFRAESEYTFERW 1033
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Cavefish
Match: farp2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:NCBI gene;Acc:103028790]) HSP 1 Score: 236.884 bits (603), Expect = 2.560e-63 Identity = 119/292 (40.75%), Postives = 176/292 (60.27%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ I+V+ LDD E F + + G + + R+ LIES +FGL++ +L + WL+ K+I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ G L C+E+T LL ++ + + +E + ++ + L ++ ++ H+ QT E+ F +LEI RK++ YG++ HPA D EG +NL+V HMG+++FQ TKINTFNWSKIRKLSFKRKRFL+KLHP+ V G ++DTLEF SR+ CK FWK C+EHH+FFR
Sbjct: 50 LQIRVQGLDDAQEFFDLESKADGQTVLTDVYRRINLIESDYFGLEFQNLQMNWVWLEPTKLIVKQVRRPVNTLFRLSVKFFPPDPGQLQEEFTRYLFSLQMKRDLMEGRLYCTENTAALLASHLVQSEIGDYDE----VADREFLKLNKLLPHQEHLQDKIMELHRRHLGQTPAESDFQVLEIARKLEMYGIRFHPAADREGTKINLSVAHMGLLVFQGNTKINTFNWSKIRKLSFKRKRFLIKLHPD----------VHGPHRDTLEFLMASRDQCKIFWKSCVEHHSFFR 327 HSP 2 Score: 105.916 bits (263), Expect = 2.337e-22 Identity = 97/327 (29.66%), Postives = 147/327 (44.95%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLV-CSKKIPSLN-FSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASAS------------ITIKSRLNHSPQEIV------SKINSPNQTKFWTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
EI Q++ +L + N ++LT + + I+ L EF IR G L KL+ KG R+F L D L+ SK + + N F V + L G I E ++ N + V TI + ++ + A + + WIED+ A S ++ R N S E+ +NS + +R + +CWH S+S LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P DSI K +V KL+ + F R E+EY + RW
Sbjct: 727 EIAAQLQSSLIRLENFQKLTELQRDLIGIENL-TAPGREF--------IREGCLYKLTKKGLQQRMFFLFSDMLLYTSKGVTATNQFKVHGQLPLH----GMIVE--ESENEWSVPHC----FTIY--------SAQRTIVVAASSKLEMTKWIEDLNMAIDMSKKSQEKSDLLLDPSLCDRSNRSSDEVSLEQESEDDVNSSRCSLDKQSHHRANTTMHVCWHRNTSVSMSDHSLAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVSTPGEADSIHKEYVFKLQFKSHVYFFRAESEYTFERW 1026
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: farp2 (FERM, RhoGEF and pleckstrin domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2993]) HSP 1 Score: 186.422 bits (472), Expect = 4.502e-48 Identity = 102/273 (37.36%), Postives = 156/273 (57.14%), Query Frame = 2
Query: 248 GSDLFQKIAIRMQLIESYFFGLQYVSLDSD--LCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKL-FILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
G L + + L+ES +FGL+ WLD +K I KQ + +++ VKF+ D + L + +T + F LQ+++D+ G L+ SE + L+ ++ + EE + + + + +L N + L++ ++ +H+ + E LLEI R+ D YG++LH A D EG S+NLAV + G+ +FQ TKINTFNW+KIRKLSFKRK FLVK HP+ ++G Y+DTLEF + R++CK FWK C+E H FFR
Sbjct: 4 GIALLTTVYKYLNLVESDYFGLELEPYPKCGFTVWLDSQKPIAKQVKNTKNVVFKLGVKFFPEDSSQLQEEITSRYQFALQVRQDLLAGRLVASEMSSSLMAACLLQADVSDYEEQRSSQQLREVQYLPNQEVLANRILD----YHRQFAGLSPAEADVQLLEIARRQDTYGLRLHQAYDKEGASINLAVGYSGVSVFQNTTKINTFNWAKIRKLSFKRKYFLVKFHPD----------IEGNYQDTLEFSMKGRDACKAFWKGCVESHAFFR 262 HSP 2 Score: 92.4337 bits (228), Expect = 5.403e-19 Identity = 81/318 (25.47%), Postives = 140/318 (44.03%), Query Frame = 2
Query: 2447 LVGNIEE-LTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYR-------WFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPN-----QTKFWTEKYRLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
L+G +++ L H+ + +++ + ++E + IR G L KL+ KG R+F L+ + S +I F V R + L +R+ T SE + S+P + + P D VTL A E S ++ + SP+ + + + +C H + S+S + LS Y+LRK+K+++ WQ+LWVV ++ LFFY+ H +ASL ++G+ I+ P+ D I K +V KL+ + F R E+EY + RW + T S++
Sbjct: 680 LLGGLQDTLLHLENVQKLMELQRDLTDMEDLAMPGREFIREGCLHKLTRKGLQQRMFFLI----IESAEIFYKLFEVGGRHVEALKQFALYHLRI-TASEREFSIPCSFTLSTPQKHVVVAANSPEEMDKWVEDVTLAASLPPPTPPLREKPVAPTPPPPDSSDDQEDSAEDEAASPRSPHGASSERLSVHQQTSSTVQVCCHRQTSVSLLDISRAAENQLSGYLLRKFKNNSGWQKLWVVFTNFCLFFYKTHQDNFPLASLPVLGYSITLPSESDGILKDYVFKLQFKSHIYFFRAESEYTFERWMEVIRSATSSSA 992
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001312.1 (pep scaffold:Pmarinus_7.0:GL477231:34421:73675:-1 gene:ENSPMAG00000001156.1 transcript:ENSPMAT00000001312.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 139.428 bits (350), Expect = 1.893e-33 Identity = 98/349 (28.08%), Postives = 163/349 (46.70%), Query Frame = 2
Query: 194 VKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLC-WLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQ---YPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSES 1228
+ LD+ N++ G L + + L E+ +FGLQ+ ++ WLD K ++KQ + + VKF+ DP+ L + T+ + LQL+ DI L C +T LL ++ + Y E+E L + + + Q L +F ++ K H+ T + F+ L + + ++FYG++LH A+D + + + V G+ ++ +I+ F W KI K+ FK K F V+L E+ ++ + F + +CK WK C+EHHTFFR AS H + + GS+FRY G T+ + Q KE + F RS S
Sbjct: 33 INLLDNTAITLRANKSEAGKALLDAVFAHLDLAETDYFGLQFADDSTETPRWLDPTKPLRKQIKRSSPYIFNFRVKFFVTDPSKLQEEYTRYHYFLQLRNDILEARLPCPHNTAALLASYIVQSELGDYSETEHLPGYLSD---LRFLPRQGL--DFEKEVAKLHKQHVGMTPADAEFNYLNVAKNVEFYGVELHYARDQSNVEIMVGVTAGGVNVYNNGVRISNFPWIKIVKIFFKLKHFFVQLRKEQ----------NETRENIIGFNLGNYRACKTLWKACVEHHTFFRMARPAS-----PPHLGFLAQYFSLGSKFRYSGRTEMQTVQYGKERSNRNRNFARSPS 361
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: epb41l5 (erythrocyte membrane protein band 4.1 like 5 [Source:ZFIN;Acc:ZDB-GENE-030616-450]) HSP 1 Score: 131.339 bits (329), Expect = 7.052e-33 Identity = 79/275 (28.73%), Postives = 138/275 (50.18%), Query Frame = 2
Query: 236 ENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRF-LVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ ++G DLF ++ + ++E +FGLQ++ WLD K I+KQ + + VKFY+ +PN LH+ LT+ LF+LQLK+DI +G+L C T + L ++ + + + ++ + Q S E E L+ + + QT + + L + ++ YG+ +H K +G +L + G+++F+ KI F W KI +L FKR + LV + ++ + + T F + +CK+ WK +EHH FFR
Sbjct: 1 KKAVGQDLFDQVMYHLDILEVDYFGLQFMDSAQVSHWLDHTKNIRKQVKIGPPYCFHMRVKFYSSEPNNLHEELTRYLFVLQLKQDILSGKLECPFETAVQLATYSLQAELGDCDPVEHNPALVSEFRFIPSQ--SEEMEEAILEKWKDCRGQTPAQAELNYLNKAKWLEMYGVDMHSVKGRDGNEYSLGLTPTGVLVFEGENKIGLFFWPKITRLDFKRTKLTLVVVEDDDQAKE---------QEHTFVFRLDHPKACKHLWKCAVEHHAFFR 264
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: epb41l5 (erythrocyte membrane protein band 4.1 like 5 [Source:ZFIN;Acc:ZDB-GENE-030616-450]) HSP 1 Score: 130.568 bits (327), Expect = 9.855e-33 Identity = 79/275 (28.73%), Postives = 138/275 (50.18%), Query Frame = 2
Query: 236 ENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRF-LVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ ++G DLF ++ + ++E +FGLQ++ WLD K I+KQ + + VKFY+ +PN LH+ LT+ LF+LQLK+DI +G+L C T + L ++ + + + ++ + Q S E E L+ + + QT + + L + ++ YG+ +H K +G +L + G+++F+ KI F W KI +L FKR + LV + ++ + + T F + +CK+ WK +EHH FFR
Sbjct: 1 KKAVGQDLFDQVMYHLDILEVDYFGLQFMDSAQVSHWLDHTKNIRKQVKIGPPYCFHMRVKFYSSEPNNLHEELTRYLFVLQLKQDILSGKLECPFETAVQLATYSLQAELGDCDPVEHNPALVSEFRFIPSQ--SEEMEEAILEKWKDCRGQTPAQAELNYLNKAKWLEMYGVDMHSVKGRDGNEYSLGLTPTGVLVFEGENKIGLFFWPKITRLDFKRTKLTLVVVEDDDQAKE---------QEHTFVFRLDHPKACKHLWKCAVEHHAFFR 264
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: epb41l5 (erythrocyte membrane protein band 4.1 like 5 [Source:ZFIN;Acc:ZDB-GENE-030616-450]) HSP 1 Score: 130.568 bits (327), Expect = 1.399e-32 Identity = 79/275 (28.73%), Postives = 138/275 (50.18%), Query Frame = 2
Query: 236 ENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRF-LVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+ ++G DLF ++ + ++E +FGLQ++ WLD K I+KQ + + VKFY+ +PN LH+ LT+ LF+LQLK+DI +G+L C T + L ++ + + + ++ + Q S E E L+ + + QT + + L + ++ YG+ +H K +G +L + G+++F+ KI F W KI +L FKR + LV + ++ + + T F + +CK+ WK +EHH FFR
Sbjct: 1 KKAVGQDLFDQVMYHLDILEVDYFGLQFMDSAQVSHWLDHTKNIRKQVKIGPPYCFHMRVKFYSSEPNNLHEELTRYLFVLQLKQDILSGKLECPFETAVQLATYSLQAELGDCDPVEHNPALVSEFRFIPSQ--SEEMEEAILEKWKDCRGQTPAQAELNYLNKAKWLEMYGVDMHSVKGRDGNEYSLGLTPTGVLVFEGENKIGLFFWPKITRLDFKRTKLTLVVVEDDDQAKE---------QEHTFVFRLDHPKACKHLWKCAVEHHAFFR 264
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO33626 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRN5]) HSP 1 Score: 227.254 bits (578), Expect = 3.365e-60 Identity = 132/348 (37.93%), Postives = 195/348 (56.03%), Query Frame = 2
Query: 185 NIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSES 1228
+KV LDD V F + G L++++ + L E +FGL Y +L WLD K IKKQ ++ + CVKFYT DP +L + T+ LF LQ+KKD+ NG L CSEST LL ++ + + + L F +Q + SE + FH+ + + + ++LL++ R+++ YG+ L+PAKD + + L LA +MGI++FQ +KINT +W+KIRKLSFKRKRFL+KLHPE + G YKD +EF SRN+CK+FWK I H FFR S +S +H R GS +R+ G TQ ++ ++++ FQR++S
Sbjct: 24 TVKVCMLDDSVVKFDIEPKVKGDILYKQVYEYLNLDEREYFGLSYYDKSDNLFWLDQLKPIKKQVKEIGKVLFRFCVKFYTADPAMLQEEYTRYLFALQVKKDLVNGGLKCSESTAALLASYVVQGELGDFDTLSCRPGYLADFQFFPEQTVDSE--ARISDFHKQHRSLSPTDCDYNLLDVARRLEMYGVILYPAKDKDNVDLELAAANMGIIVFQSGSKINTLSWAKIRKLSFKRKRFLIKLHPEIF----------GHYKDVVEFQMASRNACKSFWKVAISTHAFFR-------QSESQSPPRHRPRVFSRGSSYRFSGRTQKQIIDSMQDSFRSQPSFQRTQS 352 HSP 2 Score: 97.8265 bits (242), Expect = 2.259e-20 Identity = 45/115 (39.13%), Postives = 68/115 (59.13%), Query Frame = 2
Query: 3005 ICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCT 3349
+CWH S+S + R +S +LRK+K+ N WQ+LWVV ++ LFFY+ H + +A+L LIG+ + P+ D+I K V KL+ + F R ENEY +HRW ++ T
Sbjct: 1121 VCWHRNTSVSMHEHALSVRNQMSGDLLRKFKTGNRWQKLWVVFTNFCLFFYKTHEDEFPLANLPLIGYTVDRPSEGDNIEKDLVFKLQYKTHVYFFRSENEYSFHRWMEVIASAT 1235
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO44823 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUW8]) HSP 1 Score: 166.777 bits (421), Expect = 7.033e-42 Identity = 120/392 (30.61%), Postives = 189/392 (48.21%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLC-------WLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPE-SEELQLD--IKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHF-NASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLR-LSRRNSENKYKSNHSLSV 1321
I V+ LDD +++N+ G+ L ++ + + E ++FGLQYVS D WL K+I+KQ + CV+F+ DP+ L ++LT+ F LQ+K+DI G L C T L ++ + + +L LD + E DQ + +F E+ +FH+ QT + F+ LE+ + +D YG+ LH AKD++G L L V +G+ ++ KIN F WSKI K+ FKRKRF +++ P+ W + + + F + SCKN WK C+E+H+F+R H+ A+ L+ K+ RY G T+ +Q E + A P P +R LSRR S+ S S+
Sbjct: 35 IRCVVELLDDSEFIIDVDKNAKGTVLLNEVFRHLDIQEKHYFGLQYVSDSPDNMVGGAKEQWLQDDKIIRKQKKGTPPYIFYFCVRFFVSDPSKLVEDLTRYYFYLQIKRDILTGRLPCLYDTAAELSSYILQAELGDYDPKLHLDGYVSE---FRFIPDQ--TDDFEERAAEFHKHHIGQTPADAEFNFLEVAKTLDLYGVDLHCAKDHDGTDLFLGVSALGLTVYHNKCKINFFPWSKIVKVCFKRKRFFIQIRPD--------W--NEWTDNIIGFQMLTYRSCKNLWKVCVEYHSFYRTHYPKATEKRVLRMGSKY-----------RYKGKTE----------------YQAIEESRTHARPEPKIVRTLSRRYSKRSDSGTWSRSL 384
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO36130 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJJ3]) HSP 1 Score: 146.747 bits (369), Expect = 1.400e-38 Identity = 103/351 (29.34%), Postives = 157/351 (44.73%), Query Frame = 2
Query: 230 MNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRN 1282
+ + + G DL +A + L E +FGL Y + WLD +K IKKQ N +E+ VKFY P P+ L ++T+ + +LQ++ DI L CS + LLG ++ ++ + + + K +L L N S E +E+ + H+ + T E LE RK+ YG+ HPA+D G + + V + G+++F+ + N F W K+ LS+K + F VK P E EL T+ F + + K +K C+EHHTFFR F S T L K Y LFQ + S P F R+S +N
Sbjct: 1 LQKTAKGIDLMVAVAEHLNLDEKEYFGLLY-DHKGEKYWLDPQKEIKKQLK-GNLPHFELAVKFYEPYPSKLKHDMTRYMMVLQVRDDIICERLPCSFGAQALLGSYVVQSEFGDYDPHEH--KGNYLAGLVFSPNQSHELVERIKELHKEHRGLTPEEADTQYLEAARKLTMYGVDAHPARDGNGDEVLVGVSYAGVLVFKDDLRQNKFPWPKVVYLSYKGRDFSVKSRPGELEELTT----------TMTFKLPTEKAAKRLYKSCVEHHTFFRLSFPDPPPSK-----------------------TDSLLRMGSKHRYSDKTLFQLRNEGVPIQSAQPRFQRVSSKN 314
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO30224 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1E3]) HSP 1 Score: 134.806 bits (338), Expect = 1.609e-33 Identity = 90/301 (29.90%), Postives = 149/301 (49.50%), Query Frame = 2
Query: 185 NIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVS-LDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQ----YPESEELQL--DIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLH-PEEYLELFVLWVVQGFYKDTLEFYFE--SRNSCKNFWKKCIEHHTFFR 1057
++V LD EC +++ + G LF ++ + L E +FGL+Y+ D WL+ + IK+Q K L + VKFY +P L +++T+ F+LQL++D+ G + CS LL ++ + +PE E+ D+K F Q E ++ FH+ T ++ F L+ RK+ YG ++ A +EG ++ +A+ G+ +FQ +++ F W KI + FK K+F + L P E +YK T YF+ S+ + K WK C+EHH FFR
Sbjct: 10 TVQVAGLDSDYEC-PIDKTTKGDHLFDQVCDHIGLAEKEYFGLRYIDEKDGQFNWLEGDRSIKRQMG-KAPLHFYFAVKFYPENPTTLREDITRYQFVLQLREDLLKGRIQCSNPIHALLASYVMQAELGDLHPEEHEVAYLSDLK------FFPKQ--PPELRQKIEAFHRKHVGMTPSDAEFQYLDNVRKLPLYGRDMYQAWGDEGQAVTIAISAWGVEVFQNNRQMHRFVWPKIISIGFKSKKFSLTLRAPSE----------DDYYKSTT-IYFKCGSQRAAKRVWKVCVEHHAFFR 289
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO34391 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPH7]) HSP 1 Score: 130.954 bits (328), Expect = 2.102e-33 Identity = 83/293 (28.33%), Postives = 141/293 (48.12%), Query Frame = 2
Query: 188 IKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRK-VIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPE--SEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
+K+ LDD ++ G +F + + L+E +FGL+YV WLDL K VIK+ K VKFY DP L+H+ +T+ LQ+K+DI +G L+CS + LG ++ + + E+ + + +F I + L ++ + H++L Q + + L+ + +D YG+ HP KD + + L L + GI I + K++ F W++I K S++ K F V++H ++ K F +CK+ WK +EHH F+R
Sbjct: 16 VKISLLDDTELTCEFRRDAKGQTVFDTVCKALDLVEKDYFGLRYVDDSKQRHWLDLSKSVIKQMKSLKPPFKLFFRVKFYALDPGLIHEEITRYQCFLQIKRDILHGRLLCSYNELAELGAYIVQAELGDYDPEDQEDNYVSEFRIVPKQSEKLENKIAD----IHRSLSGQVPSVAEKNFLDKVKSLDMYGVDPHPCKDQDNVQLYLGLTPTGIAIIRDGKKVSGFEWAQIIKCSYEGKVFYVQVHKDD-------------RKANYGFRLPDPLACKHLWKCAVEHHAFYR 291
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Medaka
Match: farp2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:NCBI gene;Acc:101173454]) HSP 1 Score: 243.047 bits (619), Expect = 1.806e-65 Identity = 123/304 (40.46%), Postives = 181/304 (59.54%), Query Frame = 2
Query: 146 NFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
N + ++ G + ++VK LDD E F ++ + G L K+ +R L+ES +FGL++ ++ WL+ K I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ G LICSE+T LL ++ + + + D+ ++ + + + E ++ H+ QT E+ F +LEI RK++ YG++ HPA D EG +NLAV HMG+ +FQ +TKINTFNWSKIRKLSFKRKRFL+KLHPE V G ++D LEF SR+ CK FWK C+E+H+FFR
Sbjct: 38 NMVSGSKSPGRGLQVRVKGLDDSQEFFDIDPKAFGQTLLTKVFLRGNLMESDYFGLEFQNMQMMWVWLEPTKPIAKQVRKPANTLFRLSVKFFPPDPGQLQEEYTRYLFSLQMKRDLMEGRLICSENTGALLASHLVQSEIGDYD----DVADRDFLKANSLLPYQDKVQEIIMELHRRHLGQTPAESDFQILEIARKLEMYGVRFHPAADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPE----------VHGPHQDILEFLMASRDQCKVFWKICVEYHSFFR 327
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Medaka
Match: farp2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:NCBI gene;Acc:101173454]) HSP 1 Score: 242.276 bits (617), Expect = 5.137e-65 Identity = 123/305 (40.33%), Postives = 181/305 (59.34%), Query Frame = 2
Query: 143 SNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
N + ++ G + ++VK LDD E F ++ + G L K+ +R L+ES +FGL++ ++ WL+ K I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ G LICSE+T LL ++ + + + D+ ++ + + + E ++ H+ QT E+ F +LEI RK++ YG++ HPA D EG +NLAV HMG+ +FQ +TKINTFNWSKIRKLSFKRKRFL+KLHPE V G ++D LEF SR+ CK FWK C+E+H+FFR
Sbjct: 37 GNMVSGSKSPGRGLQVRVKGLDDSQEFFDIDPKAFGQTLLTKVFLRGNLMESDYFGLEFQNMQMMWVWLEPTKPIAKQVRKPANTLFRLSVKFFPPDPGQLQEEYTRYLFSLQMKRDLMEGRLICSENTGALLASHLVQSEIGDYD----DVADRDFLKANSLLPYQDKVQEIIMELHRRHLGQTPAESDFQILEIARKLEMYGVRFHPAADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPE----------VHGPHQDILEFLMASRDQCKVFWKICVEYHSFFR 327 HSP 2 Score: 103.219 bits (256), Expect = 1.410e-21 Identity = 95/324 (29.32%), Postives = 144/324 (44.44%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLV-CSKKIPSLN-FSVEYRWFLSDIRVG------------TISEMAKT---ANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRL---IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
EI Q++ +L + N ++LT + + I+ L EF IR G L KL+ KG R+F L D L+ SK + + N F V + L + V TI +T A +V + M D + SS L AG D N +S ++++ QE ++S + + +R + +CWH S+S LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P D I K +V KL+ + F R E+EY + RW
Sbjct: 730 EIATQLQSSLIRLENFQKLTELQRDLIGIENL-TAPGREF--------IREGCLYKLTKKGLQQRMFFLFSDMLLYTSKGVTATNQFKVHGQLPLQGMIVEESENEWSVPHCFTIYSAQRTIVVAASSKVEMGKWIEDLNMAIDLAKKSQEKSSFFLDAG--------FGDRSNRSSDEVSLE-------QESEDDMSSSHTSLDKQTHHRANTTMHVCWHRNTSVSMSDHSLAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVSTPEESDGIHKEYVFKLQFKSHVYFFRAESEYTFERW 1029
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Medaka
Match: farp2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:NCBI gene;Acc:101173454]) HSP 1 Score: 241.891 bits (616), Expect = 7.651e-65 Identity = 123/305 (40.33%), Postives = 181/305 (59.34%), Query Frame = 2
Query: 143 SNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
N + ++ G + ++VK LDD E F ++ + G L K+ +R L+ES +FGL++ ++ WL+ K I KQ + + VKF+ PDP L + T+ LF LQ+K+D+ G LICSE+T LL ++ + + + D+ ++ + + + E ++ H+ QT E+ F +LEI RK++ YG++ HPA D EG +NLAV HMG+ +FQ +TKINTFNWSKIRKLSFKRKRFL+KLHPE V G ++D LEF SR+ CK FWK C+E+H+FFR
Sbjct: 37 GNMVSGSKSPGRGLQVRVKGLDDSQEFFDIDPKAFGQTLLTKVFLRGNLMESDYFGLEFQNMQMMWVWLEPTKPIAKQVRKPANTLFRLSVKFFPPDPGQLQEEYTRYLFSLQMKRDLMEGRLICSENTGALLASHLVQSEIGDYD----DVADRDFLKANSLLPYQDKVQEIIMELHRRHLGQTPAESDFQILEIARKLEMYGVRFHPAADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPE----------VHGPHQDILEFLMASRDQCKVFWKICVEYHSFFR 327 HSP 2 Score: 100.908 bits (250), Expect = 7.342e-21 Identity = 92/319 (28.84%), Postives = 144/319 (45.14%), Query Frame = 2
Query: 2414 EIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLV-CSKKIPSLN-FSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSR----LNHSPQEIVSKINSPNQTKFWTEKYRL---------IDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRW 3325
EI Q++ +L + N ++LT + + I+ L EF IR G L KL+ KG R+F L D L+ SK + + N F V + L G I E ++ N + V TI + ++ + A + WIED+ A + + + L+ + + SP T +Y L +CW+ ++S + LS Y+LRK+K+SN WQ+LWVV ++ LFFY+ H +ASL L+G+ +S P D I K +V KL+ + F R E+EY + RW
Sbjct: 730 EIATQLQSSLIRLENFQKLTELQRDLIGIENL-TAPGREF--------IREGCLYKLTKKGLQQRMFFLFSDMLLYTSKGVTATNQFKVHGQLPLQ----GMIVE--ESENEWSVPHC----FTIY--------SAQRTIVVAASSKVEMGKWIEDLNMAIDLAKKSQEKSSFFLDAGFGDRSNLFGSPAATPELPPRYLLGQGQRPNTITHVCWYRNQNLSLSDYLRMNQNQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVSTPEESDGIHKEYVFKLQFKSHVYFFRAESEYTFERW 1021
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Medaka
Match: FARP1 (FERM, ARHGEF and pleckstrin domain-containing protein 1 [Source:NCBI gene;Acc:101165518]) HSP 1 Score: 232.646 bits (592), Expect = 5.342e-62 Identity = 123/297 (41.41%), Postives = 176/297 (59.26%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
G + I+V+ LDD E F +++ + G LF + M LIE +FGL+Y + + WLD K I KQ + VKF+ PD L + LT+ LF LQ+K+D+ G L C+ES+ L+ I+ + + EE Q HL N+ + + I++ ++FH QT E+ + +LE+ RK+D YG++LHPAKD + L+LAV H G+++FQ++T+IN FNWSKIRKLSFKRKRFL+KL P+ + Y+DTLEF SR+ CK FWK C+EHH FFR
Sbjct: 40 GRQVAIRVRMLDDTEEIFDVSQKASGKVLFDLVCSHMNLIEGDYFGLEYQNHQKMIVWLDHIKPIYKQLRRPKHAILKFSVKFFPPDHAQLLEELTRYLFALQIKQDLCCGRLTCNESSAALMISHIIQSEIGDFEE------SQCRSHLLNNNYIPDQMPLIDKIMEFHSKHIGQTPAESDYQMLEVARKLDMYGIRLHPAKDRDRTKLSLAVAHTGVLVFQRHTRINAFNWSKIRKLSFKRKRFLIKLKPD----------LNSSYQDTLEFLMASRDCCKVFWKICVEHHAFFR 320 HSP 2 Score: 106.686 bits (265), Expect = 1.330e-22 Identity = 91/345 (26.38%), Postives = 156/345 (45.22%), Query Frame = 2
Query: 2408 CQEIIVQIKETLS-LVGNIEELTHIVLMMNIIKGLFNTQEI-----EFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKK--IPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRL----------NHSPQ------EIVSKINSPNQTKFWTEKYR---LIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
C+ + ++ E + L GN+ E+ ++ ++ + K L + EF IR+G L KLS KG R+F L D ++ + + P+ F V + L + TI E + + + V P+ L G SV + A ++ W++DI+ A + T L N P+ E + + + T +R ++ +CWH S+S LS +LRK+K+SN WQ+LWVV ++ LFFY++H +ASL L+G+ ++ P+ ++I K +V KL + + R E+EY + RW + T +S
Sbjct: 705 CRAALAEVSEVVDQLQGNLVEMENLQKLLELKKDLIGVDNLVVPGREF--------IRLGCLSKLSGKGLQQRMFFLFNDVILYTTRGMTPTNQFRVHGQLPLRGL---TIRE---SEDEWGV---PY---AFTLAGQG------QSVVVAASSLTEMEKWMDDIKMAVQMAKTSNGPLSDLLTPSLADNKYPEDSSVEAESEDDMTASHTTLERPAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFSLFFYKSHQDDYPLASLPLLGYSVTIPSDNENIHKDYVFKLHFKSHVYYFRSESEYTFGRWMEVIRSATIPSS 1023
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Medaka
Match: FARP1 (FERM, ARHGEF and pleckstrin domain-containing protein 1 [Source:NCBI gene;Acc:101165518]) HSP 1 Score: 232.261 bits (591), Expect = 6.375e-62 Identity = 123/297 (41.41%), Postives = 176/297 (59.26%), Query Frame = 2
Query: 173 GGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSE--FIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFR 1057
G + I+V+ LDD E F +++ + G LF + M LIE +FGL+Y + + WLD K I KQ + VKF+ PD L + LT+ LF LQ+K+D+ G L C+ES+ L+ I+ + + EE Q HL N+ + + I++ ++FH QT E+ + +LE+ RK+D YG++LHPAKD + L+LAV H G+++FQ++T+IN FNWSKIRKLSFKRKRFL+KL P+ + Y+DTLEF SR+ CK FWK C+EHH FFR
Sbjct: 40 GRQVAIRVRMLDDTEEIFDVSQKASGKVLFDLVCSHMNLIEGDYFGLEYQNHQKMIVWLDHIKPIYKQLRRPKHAILKFSVKFFPPDHAQLLEELTRYLFALQIKQDLCCGRLTCNESSAALMISHIIQSEIGDFEE------SQCRSHLLNNNYIPDQMPLIDKIMEFHSKHIGQTPAESDYQMLEVARKLDMYGIRLHPAKDRDRTKLSLAVAHTGVLVFQRHTRINAFNWSKIRKLSFKRKRFLIKLKPD----------LNSSYQDTLEFLMASRDCCKVFWKICVEHHAFFR 320 HSP 2 Score: 106.686 bits (265), Expect = 1.215e-22 Identity = 89/340 (26.18%), Postives = 155/340 (45.59%), Query Frame = 2
Query: 2408 CQEIIVQIKETLS-LVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKK--IPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRL----------NHSPQ------EIVSKINSPNQTKFWTEKYR---LIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
C+ + ++ E + L GN+ E+ ++ ++ + K L + + IR+G L KLS KG R+F L D ++ + + P+ F V + L + TI E + + + V P+ L G SV + A ++ W++DI+ A + T L N P+ E + + + T +R ++ +CWH S+S LS +LRK+K+SN WQ+LWVV ++ LFFY++H +ASL L+G+ ++ P+ ++I K +V KL + + R E+EY + RW + T +S
Sbjct: 698 CRAALAEVSEVVDQLQGNLVEMENLQKLLELKKDLIGVDNL---VVPGREFIRLGCLSKLSGKGLQQRMFFLFNDVILYTTRGMTPTNQFRVHGQLPLRGL---TIRE---SEDEWGV---PY---AFTLAGQG------QSVVVAASSLTEMEKWMDDIKMAVQMAKTSNGPLSDLLTPSLADNKYPEDSSVEAESEDDMTASHTTLERPAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFSLFFYKSHQDDYPLASLPLLGYSVTIPSDNENIHKDYVFKLHFKSHVYYFRSESEYTFGRWMEVIRSATIPSS 1016
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000069407.1 (SMESG000069407.1) HSP 1 Score: 2114.35 bits (5477), Expect = 0.000e+0 Identity = 1069/1074 (99.53%), Postives = 1070/1074 (99.63%), Query Frame = 2
Query: 140 MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTADGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNLKCYIEEIKTFIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHXXXXXXXXXXXXXDEEEKQICQEIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKH FRRSFSGSRFRYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTA GVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNLKCYIEEIK FIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHISSLSIFLLFLSSDEEEKQICQEIIVQIKETLSLVGNIEELTHI LMMNIIKGLFNT+EIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQLRFFFRFSLSAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS
Sbjct: 1 MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHKFRRSFSGSRFRYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTAGGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNLKCYIEEIKNFIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHISSLSIFLLFLSSDEEEKQICQEIIVQIKETLSLVGNIEELTHIGLMMNIIKGLFNTREIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQLRFFFRFSLSAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 1074
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000069407.1 (SMESG000069407.1) HSP 1 Score: 2107.03 bits (5458), Expect = 0.000e+0 Identity = 1069/1084 (98.62%), Postives = 1070/1084 (98.71%), Query Frame = 2
Query: 140 MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTADGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEH----------NLKCYIEEIKTFIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHXXXXXXXXXXXXXDEEEKQICQEIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKH FRRSFSGSRFRYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTA GVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEH NLKCYIEEIK FIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHISSLSIFLLFLSSDEEEKQICQEIIVQIKETLSLVGNIEELTHI LMMNIIKGLFNT+EIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQLRFFFRFSLSAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS
Sbjct: 1 MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHKFRRSFSGSRFRYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTAGGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHLHLQHRQMLSNLKCYIEEIKNFIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHISSLSIFLLFLSSDEEEKQICQEIIVQIKETLSLVGNIEELTHIGLMMNIIKGLFNTREIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQLRFFFRFSLSAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 1084
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000069407.1 (SMESG000069407.1) HSP 1 Score: 2086.61 bits (5405), Expect = 0.000e+0 Identity = 1059/1074 (98.60%), Postives = 1060/1074 (98.70%), Query Frame = 2
Query: 140 MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTADGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNLKCYIEEIKTFIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHXXXXXXXXXXXXXDEEEKQICQEIIVQIKETLSLVGNIEELTHIVLMMNIIKGLFNTQEIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQXXXXXXXXXXAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 3361
MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEY GFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKH FRRSFSGSRFRYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTA GVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNLKCYIEEIK FIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHISSLSIFLLFLSSDEEEKQICQEIIVQIKETLSLVGNIEELTHI LMMNIIKGLFNT+EIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQLRFFFRFSLSAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS
Sbjct: 1 MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEY----------GFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHKFRRSFSGSRFRYIGLTQFELEQLQKETYEIDNLFQRSESAGRLASPNPSFLRLSRRNSENKYKSNHSLSVPIKPSINNSFVSENGYEEDGNYSEAGKNDHFQWERLKTVVKNTDNHCLQFGNHTAVNLTAGGVENTDSTGSNEHELNFSFPDGLHKSNKYFSSASTSNETVPLSLIDVPEVNNSKDDHENIVYETVCHSIFDEYAFVPNLLAQISNSQCSKLDVFVNHHAQYQCKATSDSFNCDKSTCLPSDSTEVISYQTILQSIEKDLLFNGFMYLKELEIIFKILHEYKDKVEITCKTFKNMIFNLNEIKMATKSMLEKLEQIIQNNTISLIKPKEHIDKFLAIMNDYHFQIEHNLKCYIEEIKNFIYALNQCEYSSDCFDKFQFENDGESETNFLRLLLSPIIQQRAHISSLSIFLLFLSSDEEEKQICQEIIVQIKETLSLVGNIEELTHIGLMMNIIKGLFNTREIEFCQISEINPIRIGWLQKLSNKGASNRLFILLPDQLVCSKKIPSLNFSVEYRWFLSDIRVGTISEMAKTANGYEVTSSPFDSITIMLWDPGARDPSYSSVTLLAGTIKSRSIWIEDIRNAASASITIKSRLNHSPQEIVSKINSPNQTKFWTEKYRLIDICWHERISISKRQLRFFFRFSLSAYILRKYKSSNNWQRLWVVLSDCHLFFYQNHISQQAIASLCLIGFRISEPNLRDSISKSWVIKLEKELKTCFLRIENEYFYHRWRTALSYCTFSNS 1064
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000048801.1 (SMESG000048801.1) HSP 1 Score: 268.47 bits (685), Expect = 2.304e-72 Identity = 156/386 (40.41%), Postives = 226/386 (58.55%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETY--EIDNLFQRSESAGRLASPNPSFLRLSRRNSENKY----KSNHSLSV 1321
I ++ LDD V F++N ++G +LF I + ++E+ +F L+YV+ + CW++ K I KQ ++ + VKFYT PNLL + T+ LF LQ+K+DI +G+LICS +T LL ++ + + + + I +L HL + E + + ++FH+T + E F LL+ RKI++YG+K+H AKD+E L LNL+V HMG+V+FQ TKINTF+W+KIRKLSFKRK+FL+KLHPE Y G+YK +EFYFE+R+ CK FWKKCIEHH FFR +S LK K + GS FRY G TQ EL + +E+Y + DN + PS R+S+ NK+ KS H ++
Sbjct: 24 IQARIFLLDDSVHTFSINSCAIGHELFMAIIEKQNILEADYFDLEYVNSEGVRCWINHNKCIVKQVGAGKDMVFIFAVKFYTSHPNLLEEEYTRYLFALQIKRDIVSGQLICSTNTAALLASYIVQAEIGDFLDDEY-IDNSYLRHLKLVNQPNEEILNKIMEFHKTHIGMSATEADFHLLDTARKIEYYGVKMHLAKDHENLPLNLSVTHMGVVVFQNLTKINTFSWAKIRKLSFKRKKFLIKLHPEGY----------GYYKGMVEFYFETRDDCKRFWKKCIEHHAFFRC---PASEKSLKKTPKVV----TKGSSFRYCGRTQKELIEYVRESYSSKRDNFVR------------PSKARVSKSPHNNKHARHGKSYHPFAI 379
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000048801.1 (SMESG000048801.1) HSP 1 Score: 268.47 bits (685), Expect = 2.464e-72 Identity = 156/386 (40.41%), Postives = 226/386 (58.55%), Query Frame = 2
Query: 182 INIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLIESYFFGLQYVSLDSDLCWLDLRKVIKKQTDYKNELAYEICVKFYTPDPNLLHDNLTKKLFILQLKKDITNGELICSESTKILLGGLFIKFQYPESEELQLDIKEQFLIHLFNDQNLSSEFIEQCLKFHQTLKCQTINETHFDLLEIFRKIDFYGMKLHPAKDNEGLSLNLAVYHMGIVIFQKYTKINTFNWSKIRKLSFKRKRFLVKLHPEEYLELFVLWVVQGFYKDTLEFYFESRNSCKNFWKKCIEHHTFFRGHFNASSTSCLKSHQKHIXXXXXXXXXXXYIGLTQFELEQLQKETY--EIDNLFQRSESAGRLASPNPSFLRLSRRNSENKY----KSNHSLSV 1321
I ++ LDD V F++N ++G +LF I + ++E+ +F L+YV+ + CW++ K I KQ ++ + VKFYT PNLL + T+ LF LQ+K+DI +G+LICS +T LL ++ + + + + I +L HL + E + + ++FH+T + E F LL+ RKI++YG+K+H AKD+E L LNL+V HMG+V+FQ TKINTF+W+KIRKLSFKRK+FL+KLHPE Y G+YK +EFYFE+R+ CK FWKKCIEHH FFR +S LK K + GS FRY G TQ EL + +E+Y + DN + PS R+S+ NK+ KS H ++
Sbjct: 24 IQARIFLLDDSVHTFSINSCAIGHELFMAIIEKQNILEADYFDLEYVNSEGVRCWINHNKCIVKQVGAGKDMVFIFAVKFYTSHPNLLEEEYTRYLFALQIKRDIVSGQLICSTNTAALLASYIVQAEIGDFLDDEY-IDNSYLRHLKLVNQPNEEILNKIMEFHKTHIGMSATEADFHLLDTARKIEYYGVKMHLAKDHENLPLNLSVTHMGVVVFQNLTKINTFSWAKIRKLSFKRKKFLIKLHPEGY----------GYYKGMVEFYFETRDDCKRFWKKCIEHHAFFRC---PASEKSLKKTPKVV----TKGSSFRYCGRTQKELIEYVRESYSSKRDNFVR------------PSKARVSKSPHNNKHARHGKSYHPFAI 379 The following BLAST results are available for this feature:
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of FERM, RhoGEF and pleckstrin domain-containing protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033884 ID=SMED30033884|Name=FERM, RhoGEF and pleckstrin domain-containing protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=4732bpback to top protein sequence of SMED30033884-orf-1 >SMED30033884-orf-1 ID=SMED30033884-orf-1|Name=SMED30033884-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1075bp MSNFQNKLENSGGLINIKVKYLDDHVECFTMNENSLGSDLFQKIAIRMQLback to top Annotated Terms
The following terms have been associated with this transcript:
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