Non-lysosomal glucosylceramidase

Overview


Name	Non-lysosomal glucosylceramidase
Smed ID	SMED30033866
Length (bp)	2801

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Non-lysosomal glucosylceramidase (SMED30033866) t-SNE clustered cells

Violin plots show distribution of expression levels for Non-lysosomal glucosylceramidase (SMED30033866) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Non-lysosomal glucosylceramidase (SMED30033866) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Non-lysosomal glucosylceramidase (SMED30033866) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033866

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
pharynx	SMED30033866	SMESG000080285.1	dd_Smed_v4_9887_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30033866	SMESG000080285.1	dd_Smed_v4_9887_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Human
Match: GBA2 (glucosylceramidase beta 2 [Source:HGNC Symbol;Acc:HGNC:18986])

HSP 1 Score: 612.068 bits (1577), Expect = 0.000e+0
Identity = 350/820 (42.68%), Postives = 484/820 (59.02%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIA--TCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNID--CSFFADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLKSCGV--PDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIW 2549
            +VP +GW + L      K KP+       S +   +   +RYL + YR+   E K PFID IN V  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+QF V +RR G TVYQQVLS+ + P  L+S   WNW      A Y  L+PRAWTVY +  Q + L CRQI+P++PH+Y+DS LP+ VF W+  N G E L +SI   ++NG G  D+A  GL     NE F     G ++R  +           M      T++ +   +T    ++     +++W++L+ +G L     +     K + IA   C    ++P  +   + F   W MP + F      + RRY R+F  D        +  YA+     WEE+I  WQ P+L++   P+WYKSALFNELYF+ DGGTVWL+ +  S+  E G ++   R   + DYG FGYLEG EYRMYNTYDVH Y+S++L+ LWPKL+ S+QY++A +T   D +   Y+  G +        IPHD+GDP++EP++++NAY +++T  WKDLN KFVLQV+RD+ +  ++++LK M P+ L VM+  + +DKD DGLIEN GYADQTYD W+  G SAY GGLWL A+  +  M+           F+  LS+G++AY   LW G Y+ YD     +S SVM+DQ  G W+LK+CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E    E +   EG Y+TV+E  GL FQTPE+Y     FRSL YMRPL+IW
Sbjct:   80 QVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQFTVCLRREGQTVYQQVLSLER-PSVLRS---WNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDDAPGGL----WNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDST---GQQVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCR-LEFSLAWDMPRIMFGAKGQVHYRRYTRFFGQDGD--AAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLR-DYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIW 884

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Human
Match: GBA2 (glucosylceramidase beta 2 [Source:HGNC Symbol;Acc:HGNC:18986])

HSP 1 Score: 561.222 bits (1445), Expect = 0.000e+0
Identity = 324/771 (42.02%), Postives = 453/771 (58.75%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIA--TCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNID--CSFFADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLKSCGV--PDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLE 2402
            +VP +GW + L      K KP+       S +   +   +RYL + YR+   E K PFID IN V  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+QF V +RR G TVYQQVLS+ + P  L+S   WNW      A Y  L+PRAWTVY +  Q + L CRQI+P++PH+Y+DS LP+ VF W+  N G E L +SI   ++NG G  D+A  GL     NE F     G ++R  +           M      T++ +   +T    ++     +++W++L+ +G L     +     K + IA   C    ++P  +   + F   W MP + F      + RRY R+F  D        +  YA+     WEE+I  WQ P+L++   P+WYKSALFNELYF+ DGGTVWL+ +  S+  E G ++   R   + DYG FGYLEG EYRMYNTYDVH Y+S++L+ LWPKL+ S+QY++A +T   D +   Y+  G +        IPHD+GDP++EP++++NAY +++T  WKDLN KFVLQV+RD+ +  ++++LK M P+ L VM+  + +DKD DGLIEN GYADQTYD W+  G SAY GGLWL A+  +  M+           F+  LS+G++AY   LW G Y+ YD     +S SVM+DQ  G W+LK+CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E
Sbjct:   80 QVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQFTVCLRREGQTVYQQVLSLER-PSVLRS---WNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDDAPGGL----WNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDST---GQQVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCR-LEFSLAWDMPRIMFGAKGQVHYRRYTRFFGQD--GDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLR-DYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQE 835

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Human
Match: GBA2 (glucosylceramidase beta 2 [Source:HGNC Symbol;Acc:HGNC:18986])

HSP 1 Score: 89.3521 bits (220), Expect = 7.904e-20
Identity = 50/103 (48.54%), Postives = 62/103 (60.19%), Query Frame = 3

Query: 2115 GSYFKYDE----RSCSVMADQLCGHWYLKSCGVP--DNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLE 2402
            G Y+ YD     +S SVM+DQ  G W+LK+CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E
Sbjct:   34 GRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQE 136

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Celegans
Match: hpo-13 (Non-lysosomal glucosylceramidase [Source:UniProtKB/TrEMBL;Acc:Q6EUT4])

HSP 1 Score: 560.836 bits (1444), Expect = 0.000e+0
Identity = 317/836 (37.92%), Postives = 468/836 (55.98%), Query Frame = 3

Query:  153 GWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKT--ANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGK--EELTISICCVIKNGTG-------------LLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMS-KSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKN--EDYLKYMMPIVLEVMKKCL-SWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCS--FFADALSKGKKAYVDKLWTGSYFKYDERSCS---VMADQLCGHWYLKSCGVPD--NEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQ 2573
            GW    D  P  K  P+  P   QIY  +    RY  Y + +   + +K FI+   P+  +P YGVP GGIG GAI R +RG FC+FSL PG+ E+K     A+QFI++VR     +YQ+VLS          L+ W+++FP     Y GLFPR+WT + + E ++ +  RQ+SPV+PH Y+D+  P+C+F  +  N G    E  IS+    +NGTG               +   +GL  ++  +E   G S+   I  M C+YGL      + +T+ C     +   +         LW +L   GD+   + + + + +++ +A C +  + P S K+H+  +   W MP VHF      Y RRY R+F   +       +   A+R  + WE +IE WQ PIL + K P WYKSA+FNELYF+ DGGTVW +        E   S        +I  G FGYLE  EYRM NTYDVH Y+S++L  LWP+L+ +IQ    D           +  +G      +   +PHD+G+P +EP++  NAY M++T +WKDLN K+VL  +RD++VL N  ED+L +  P V  +M + L +WD+DGDG+IEN G ADQTYDAW  +G SAY G LWL +L     M+  +  D +   F + L K KK ++D LWTG+YF++ ERS S   VMADQLCG+W+L+S   P+  +E+     VR+ L TI++ N    G  + GA+NG  P+   D   +Q++E W GV YA+A+ +  +    +A+    G+Y T +E  GLQ+QTPE+ +++  +R++GYMRPL+IWA+Q++L +
Sbjct:   36 GWKARGDRKPKDKRVPFNRPTPYQIYEALPFVRRYFMY-WMKHTFDKEKLFINTFQPLKHKPYYGVPCGGIGCGAIGRDFRGGFCKFSLRPGLVEHKVDVVAADQFILSVRENDRCIYQKVLSAADVQRPSGQLSTWDFKFPKKNVHYRGLFPRSWTTFRVPELELTVVIRQVSPVLPHNYEDTTYPVCLFLIDVENGGSASREYEISVAFTFRNGTGNRRWEREAECSGVKFETEEEGLKPTTTAQEKISGVSLYHTISSMPCTYGLATTHREHTTTTVCERFDPSRNGA--------ALWNHLKQTGDVPSCEEECLINAREMAVAVCNRFTLPPNSTKTHD--YALSWDMPKVHFGSVARSYHRRYTRFFEASEAGSAADSLCVRALRLKDKWESEIEAWQSPILNHKKLPDWYKSAIFNELYFITDGGTVWFEFDENWAEHETHLSHYTKDKMKEI--GRFGYLESWEYRMVNTYDVHFYASFALAELWPELEITIQSEFTDQVYHSIEKPTRFHMEGDWANVKTASRVPHDLGNPADEPWIATNAYVMHDTGKWKDLNMKYVLTSWRDYVVLSNEHEDFLFHTWPAVRMIMLEALENWDQDGDGMIENFGKADQTYDAWQMEGVSAYCGSLWLASLRVAIEMAGLMKDDETQQLFRNTLEKAKKVFIDTLWTGTYFRFCERSRSRETVMADQLCGYWFLQSVS-PELADELLPNHMVRSALDTIYRLNVCKFGNGRMGAVNGMKPSGVVDREYIQADEMWTGVTYAVASLLIQQGEVEKAFHTASGSYLTCFEETGLQYQTPEALYESKFYRAIGYMRPLSIWAMQWSLKK 857

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Query:  153 GWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKT--ANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGK--EELTISICCVIKNGTG-------------LLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMS-KSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKN--EDYLKYMMPIVLEVMKKCL-SWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCS--FFADALSKGKKAYVDKLWTGSYFKYDERSCS---VMADQLCGHWYLKSCGVPD--NEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQ 2573
            GW    D  P  K  P+  P   QIY  +    RY  Y + +   + +K FI+   P+  +P YGVP GGIG GAI R +RG FC+FSL PG+ E+K     A+QFI++VR     +YQ+VLS          L+ W+++FP     Y GLFPR+WT + + E ++ +  RQ+SPV+PH Y+D+  P+C+F  +  N G    E  IS+    +NGTG               +   +GL  ++  +E   G S+   I  M C+YGL      + +T+ C     +   +         LW +L   GD+   + + + + +++ +A C +  + P S K+H+  +   W MP VHF      Y RRY R+F   +       +   A+R  + WE +IE WQ PIL + K P WYKSA+FNELYF+ DGGTVW +        E   S        +I  G FGYLE  EYRM NTYDVH Y+S++L  LWP+L+ +IQ    D           +  +G      +   +PHD+G+P +EP++  NAY M++T +WKDLN K+VL  +RD++VL N  ED+L +  P V  +M + L +WD+DGDG+IEN G ADQTYDAW  +G SAY G LWL +L     M+  +  D +   F + L K KK ++D LWTG+YF++ ERS S   VMADQLCG+W+L+S   P+  +E+     VR+ L TI++ N    G  + GA+NG  P+   D   +Q++E W GV YA+A+ +  +    +A+    G+Y T +E  GLQ+QTPE+ +++  +R++GYMRPL+IWA+Q++L +
Sbjct:   36 GWKARGDRKPKDKRVPFNRPTPYQIYEALPFVRRYFMY-WMKHTFDKEKLFINTFQPLKHKPYYGVPCGGIGCGAIGRDFRGGFCKFSLRPGLVEHKVDVVAADQFILSVRENDRCIYQKVLSAADVQRPSGQLSTWDFKFPKKNVHYRGLFPRSWTTFRVPELELTVVIRQVSPVLPHNYEDTTYPVCLFLIDVENGGSASREYEISVAFTFRNGTGNRRWEREAECSGVKFETEEEGLKPTTTAQEKISGVSLYHTISSMPCTYGLATTHREHTTTTVCERFDPSRNGA--------ALWNHLKQTGDVPSCEEECLINAREMAVAVCNRFTLPPNSTKTHD--YALSWDMPKVHFGSVARSYHRRYTRFFEASEAGSAADSLCVRALRLKDKWESEIEAWQSPILNHKKLPDWYKSAIFNELYFITDGGTVWFEFDENWAEHETHLSHYTKDKMKEI--GRFGYLESWEYRMVNTYDVHFYASFALAELWPELEITIQSEFTDQVYHSIEKPTRFHMEGDWANVKTASRVPHDLGNPADEPWIATNAYVMHDTGKWKDLNMKYVLTSWRDYVVLSNEHEDFLFHTWPAVRMIMLEALENWDQDGDGMIENFGKADQTYDAWQMEGVSAYCGSLWLASLRVAIEMAGLMKDDETQQLFRNTLEKAKKVFIDTLWTGTYFRFCERSRSRETVMADQLCGYWFLQSVS-PELADELLPNHMVRSALDTIYRLNVCKFGNGRMGAVNGMKPSGVVDREYIQADEMWTGVTYAVASLLIQQGEVEKAFHTASGSYLTCFEETGLQYQTPEALYESKFYRAIGYMRPLSIWAMQWSLKK 857

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Celegans
Match: hpo-13 (Non-lysosomal glucosylceramidase [Source:UniProtKB/TrEMBL;Acc:Q6EUT4])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 317/836 (37.92%), Postives = 468/836 (55.98%), Query Frame = 3

Query:  153 GWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKT--ANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGK--EELTISICCVIKNGTG-------------LLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMS-KSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKN--EDYLKYMMPIVLEVMKKCL-SWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCS--FFADALSKGKKAYVDKLWTGSYFKYDERSCS---VMADQLCGHWYLKSCGVPD--NEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQ 2573
            GW    D  P  K  P+  P   QIY  +    RY  Y + +   + +K FI+   P+  +P YGVP GGIG GAI R +RG FC+FSL PG+ E+K     A+QFI++VR     +YQ+VLS          L+ W+++FP     Y GLFPR+WT + + E ++ +  RQ+SPV+PH Y+D+  P+C+F  +  N G    E  IS+    +NGTG               +   +GL  ++  +E   G S+   I  M C+YGL      + +T+ C     +   +         LW +L   GD+   + + + + +++ +A C +  + P S K+H+  +   W MP VHF      Y RRY R+F   +       +   A+R  + WE +IE WQ PIL + K P WYKSA+FNELYF+ DGGTVW +        E   S        +I  G FGYLE  EYRM NTYDVH Y+S++L  LWP+L+ +IQ    D           +  +G      +   +PHD+G+P +EP++  NAY M++T +WKDLN K+VL  +RD++VL N  ED+L +  P V  +M + L +WD+DGDG+IEN G ADQTYDAW  +G SAY G LWL +L     M+  +  D +   F + L K KK ++D LWTG+YF++ ERS S   VMADQLCG+W+L+S   P+  +E+     VR+ L TI++ N    G  + GA+NG  P+   D   +Q++E W GV YA+A+ +  +    +A+    G+Y T +E  GLQ+QTPE+ +++  +R++GYMRPL+IWA+Q++L +
Sbjct:   44 GWKARGDRKPKDKRVPFNRPTPYQIYEALPFVRRYFMY-WMKHTFDKEKLFINTFQPLKHKPYYGVPCGGIGCGAIGRDFRGGFCKFSLRPGLVEHKVDVVAADQFILSVRENDRCIYQKVLSAADVQRPSGQLSTWDFKFPKKNVHYRGLFPRSWTTFRVPELELTVVIRQVSPVLPHNYEDTTYPVCLFLIDVENGGSASREYEISVAFTFRNGTGNRRWEREAECSGVKFETEEEGLKPTTTAQEKISGVSLYHTISSMPCTYGLATTHREHTTTTVCERFDPSRNGA--------ALWNHLKQTGDVPSCEEECLINAREMAVAVCNRFTLPPNSTKTHD--YALSWDMPKVHFGSVARSYHRRYTRFFEASEAGSAADSLCVRALRLKDKWESEIEAWQSPILNHKKLPDWYKSAIFNELYFITDGGTVWFEFDENWAEHETHLSHYTKDKMKEI--GRFGYLESWEYRMVNTYDVHFYASFALAELWPELEITIQSEFTDQVYHSIEKPTRFHMEGDWANVKTASRVPHDLGNPADEPWIATNAYVMHDTGKWKDLNMKYVLTSWRDYVVLSNEHEDFLFHTWPAVRMIMLEALENWDQDGDGMIENFGKADQTYDAWQMEGVSAYCGSLWLASLRVAIEMAGLMKDDETQQLFRNTLEKAKKVFIDTLWTGTYFRFCERSRSRETVMADQLCGYWFLQSVS-PELADELLPNHMVRSALDTIYRLNVCKFGNGRMGAVNGMKPSGVVDREYIQADEMWTGVTYAVASLLIQQGEVEKAFHTASGSYLTCFEETGLQYQTPEALYESKFYRAIGYMRPLSIWAMQWSLKK 865

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Celegans
Match: hpo-13 (Non-lysosomal glucosylceramidase [Source:UniProtKB/TrEMBL;Acc:Q6EUT4])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 317/836 (37.92%), Postives = 468/836 (55.98%), Query Frame = 3

Query:  153 GWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKT--ANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGK--EELTISICCVIKNGTG-------------LLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMS-KSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKN--EDYLKYMMPIVLEVMKKCL-SWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCS--FFADALSKGKKAYVDKLWTGSYFKYDERSCS---VMADQLCGHWYLKSCGVPD--NEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQ 2573
            GW    D  P  K  P+  P   QIY  +    RY  Y + +   + +K FI+   P+  +P YGVP GGIG GAI R +RG FC+FSL PG+ E+K     A+QFI++VR     +YQ+VLS          L+ W+++FP     Y GLFPR+WT + + E ++ +  RQ+SPV+PH Y+D+  P+C+F  +  N G    E  IS+    +NGTG               +   +GL  ++  +E   G S+   I  M C+YGL      + +T+ C     +   +         LW +L   GD+   + + + + +++ +A C +  + P S K+H+  +   W MP VHF      Y RRY R+F   +       +   A+R  + WE +IE WQ PIL + K P WYKSA+FNELYF+ DGGTVW +        E   S        +I  G FGYLE  EYRM NTYDVH Y+S++L  LWP+L+ +IQ    D           +  +G      +   +PHD+G+P +EP++  NAY M++T +WKDLN K+VL  +RD++VL N  ED+L +  P V  +M + L +WD+DGDG+IEN G ADQTYDAW  +G SAY G LWL +L     M+  +  D +   F + L K KK ++D LWTG+YF++ ERS S   VMADQLCG+W+L+S   P+  +E+     VR+ L TI++ N    G  + GA+NG  P+   D   +Q++E W GV YA+A+ +  +    +A+    G+Y T +E  GLQ+QTPE+ +++  +R++GYMRPL+IWA+Q++L +
Sbjct:   73 GWKARGDRKPKDKRVPFNRPTPYQIYEALPFVRRYFMY-WMKHTFDKEKLFINTFQPLKHKPYYGVPCGGIGCGAIGRDFRGGFCKFSLRPGLVEHKVDVVAADQFILSVRENDRCIYQKVLSAADVQRPSGQLSTWDFKFPKKNVHYRGLFPRSWTTFRVPELELTVVIRQVSPVLPHNYEDTTYPVCLFLIDVENGGSASREYEISVAFTFRNGTGNRRWEREAECSGVKFETEEEGLKPTTTAQEKISGVSLYHTISSMPCTYGLATTHREHTTTTVCERFDPSRNGA--------ALWNHLKQTGDVPSCEEECLINAREMAVAVCNRFTLPPNSTKTHD--YALSWDMPKVHFGSVARSYHRRYTRFFEASEAGSAADSLCVRALRLKDKWESEIEAWQSPILNHKKLPDWYKSAIFNELYFITDGGTVWFEFDENWAEHETHLSHYTKDKMKEI--GRFGYLESWEYRMVNTYDVHFYASFALAELWPELEITIQSEFTDQVYHSIEKPTRFHMEGDWANVKTASRVPHDLGNPADEPWIATNAYVMHDTGKWKDLNMKYVLTSWRDYVVLSNEHEDFLFHTWPAVRMIMLEALENWDQDGDGMIENFGKADQTYDAWQMEGVSAYCGSLWLASLRVAIEMAGLMKDDETQQLFRNTLEKAKKVFIDTLWTGTYFRFCERSRSRETVMADQLCGYWFLQSVS-PELADELLPNHMVRSALDTIYRLNVCKFGNGRMGAVNGMKPSGVVDREYIQADEMWTGVTYAVASLLIQQGEVEKAFHTASGSYLTCFEETGLQYQTPEALYESKFYRAIGYMRPLSIWAMQWSLKK 894

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Celegans
Match: R08F11.1 (Non-lysosomal glucosylceramidase [Source:UniProtKB/TrEMBL;Acc:O01893])

HSP 1 Score: 532.717 bits (1371), Expect = 2.238e-176
Identity = 306/822 (37.23%), Postives = 451/822 (54.87%), Query Frame = 3

Query:  153 GWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEY-KTANANQFIVTVRRRGI--TVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSS-LNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQI-DYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDW--IVLKNE--DYLKYMMPIVLEVMKKCLS-WDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSFFADALSKGKKAYVDKLWTGSYFKYD---ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            GW    D  P         PR       +   +R   + +  +    ++ FID  N        GVP+GGIG G+I   +RG F RFS+IPGI E  +T   NQFIVTV  +     +YQ +LS  + P  +  L  W+   P+    Y GLFPRAW  + +    + +    +SPVIP +Y DS LPL  FE++  N   EE+ +SI    +NGTG      + L  S  + ++     ++   +K M  +Y +G  +         +   +T    + N  G + LW +L + G LS       K  K++ IA C    V P   +H  +F   W+MP VHF      Y RRY R+F+  D    T+ +  + ++N  +W++KIE+WQ P+L + K P WYKSA+FNELY++VDG TVW +        +  +S+   + + Q  +YG FGY+E  EY M NTYDVH YSSW+++  WP+++ S+Q + AD    VD+++   +  G   T  S+  IPHD+G P  +P++  NAY +++T +WKDLN KFV+  +RDW  I L +E    L++ +    +++   L  WDKD DG+IEN G+ADQTYD W   G SAY G LW+ AL S   M K   +    + + L     AY+ KLW G++FK+D   E S  VMADQLCG W + +   P      +DK+++ L TIF+ N       + GA+NG L ++  D SS+QSEE W G+ YAL+A M  +  D +A+   EG +++++  + LQ+QTPE+    G +R+LGYMRPL+IWAIQ+ALD+R
Sbjct:   14 GWKARGDRIPEFPNPRPFFPRLKHSIKLIPLFVRVALHTFV-EWWNGREAFIDIFNVFRHFTYTGVPLGGIGCGSIGTDFRGGFNRFSIIPGIKEQTETQKCNQFIVTVHSKKTFELIYQSILSCAEFPATV--LPKWDTTIPAEDVRYRGLFPRAWQEFRLGSSGVTVVVEHLSPVIPGDYSDSSLPLANFEFHVFNDSYEEVEVSITMSFRNGTGNRKWNDENLCQSQKIQKDTMVVRTLAHTVKGMPVTYAIGTEEK--------NGSKVTTCLFDPNGTGGR-LWSDLEAYGHLSSYDHLPSK-PKELGIAVCSSFFVPP-DGAHNTQFSLTWYMPQVHFGTAERFYNRRYCRFFNGPDADEVTAAICRHGLQNFSTWQKKIEDWQAPVLNDQKLPEWYKSAIFNELYYIVDGSTVWFE---YDPDWKTEESLMSEQTEKQFKEYGRFGYMESWEYFMINTYDVHFYSSWAILKNWPQIEMSMQLDFADQMDRVDNNIATSLADGEQMTIKSVDRIPHDMGHPMADPWIHTNAYILHDTGRWKDLNLKFVISCYRDWKLIELGSEKGQVLEFFLGKCTKIVDGALECWDKDNDGMIENDGFADQTYDVWKMTGTSAYCGSLWIAALSSYIEMLKQSGLPTKHYEEKLEMAYDAYIGKLWNGTFFKFDELPENSKIVMADQLCGFWAMTAMDEPVQ--ISKDKMKSALDTIFKYNVQMYNNGRCGAVNGYLTSERVDGSSIQSEEVWAGITYALSAMMIEKGMDEQAFKTSEGLFESIWHRFPLQYQTPEAITSDGMYRALGYMRPLSIWAIQHALDRR 816

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Fly
Match: CG33090 (gene:FBgn0028916 transcript:FBtr0343675)

HSP 1 Score: 411.764 bits (1057), Expect = 1.028e-128
Identity = 307/914 (33.59%), Postives = 458/914 (50.11%), Query Frame = 3

Query:  102 VKLFDTRNIDEVK-VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRR-RGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL-NEEFFEGCSIRQKIKDMDCSYGLG--VMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRN-------VESWE------EKIENWQKPILENSKY------PSWYK--SALFNELYF----VVDGGTVWLD-------------------------NVSVSVSLENGDSIAIARNK-HQIDYG--------------TFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNI------ADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD---ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTK-------DTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            +KL      +E+  VP+YG  +  D   P K          Q    V    RY  Y Y +  +E ++ ++D     + + IYGVP+GGIG G I RGY GEFCRF + PGIYEY    ANQFIVT++  +G T++Q +LS   +    Q L+ W+     +R +Y GL+PR+WT YD+    ++L CRQ+SPVIPHEY++S LP  VF W+  N   +E  +SI    KNGTG     ++G   S L +E   +G SIRQKI +M CSY L   V+  ++++       +             ++LW  L  +G LS   + E    KDI +A CG+V +KPM+ SH++ FV  W MP + F      + R Y ++F  DD      ++ EYA+R        +++W+      E + +W K  + N  Y        W K  S+L  EL +    +  G   +L+                         N+ VS+  +  D+IA   N   ++ Y                 G  +   + + N Y++H  + W  +     LQ    Y +      A S  +   S I +I K +L     L++  +   +  +E      + +MY      + N K  L        +    YLK M      +M++ + +DKD DGLIEN+   DQTYD+W+  G SAY  GLWL AL ++  M+  L+   DC  + D L KGK++  +KLW GSY+++D       ++MADQLCGHWYLKSCG  D E++ ++ VRT L+ I+ NN +       GA NG + N ++       D S++Q+EE W GV YALAATM  E    EA+    G YKT+ +  G+ F+TPE+ +    +RS+GYMRPL+IW++Q AL++R
Sbjct:   36 LKLQQQEESNEIAAVPKYGLKLKFDHVWPEKRIQNVRASIRQTLPMVPLVCRYAAY-YWKVSREGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLS-KCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNG----------EQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMA-SHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYF--DDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESL---YELYSQDNKRKNSADEKQQNRKSASMY----INETNGKVYL--------MDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCGF-DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSMQVALERR 918

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Fly
Match: CG33090 (gene:FBgn0028916 transcript:FBtr0343674)

HSP 1 Score: 406.371 bits (1043), Expect = 1.409e-126
Identity = 309/936 (33.01%), Postives = 458/936 (48.93%), Query Frame = 3

Query:  102 VKLFDTRNIDEVK-VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRR-RGITVYQQVLSVHK----------------------APEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL-NEEFFEGCSIRQKIKDMDCSYGLG--VMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESW-------------EEKIENWQKPILENSKY------PSWYK--SALFNELYF----VVDGGTVWLD-------------------------NVSVSVSLENGDSIAIARNK-HQIDYG--------------TFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNI------ADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD---ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTK-------DTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            +KL      +E+  VP+YG  +  D   P K          Q    V    RY  Y Y +  +E ++ ++D     + + IYGVP+GGIG G I RGY GEFCRF + PGIYEY    ANQFIVT++  +G T++Q +LS  +                      +    Q L+ W+     +R +Y GL+PR+WT YD+    ++L CRQ+SPVIPHEY++S LP  VF W+  N   +E  +SI    KNGTG     ++G   S L +E   +G SIRQKI +M CSY L   V+  ++++       +             ++LW  L  +G LS   + E    KDI +A CG+V +KPM+ SH++ FV  W MP + F      + R Y ++F  DD      ++ EYA+R   +W             +E + +W K  + N  Y        W K  S+L  EL +    +  G   +L+                         N+ VS+  +  D+IA   N   ++ Y                 G  +   + + N Y++H  + W  +     LQ    Y +      A S  +   S I +I K +L     L++  +   +  +E      + +MY      + N K  L    D I      YLK M      +M++ + +DKD DGLIEN+   DQTYD+W+  G SAY  GLWL AL ++  M+  L+   DC  + D L KGK++  +KLW GSY+++D       ++MADQLCGHWYLKSCG  D E++ ++ VRT L+ I+ NN +       GA NG + N ++       D S++Q+EE W GV YALAATM  E    EA+    G YKT+ +  G+ F+TPE+ +    +RS+GYMRPL+IW++Q AL++R
Sbjct:   36 LKLQQQEESNEIAAVPKYGLKLKFDHVWPEKRIQNVRASIRQTLPMVPLVCRYAAY-YWKVSREGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLSKCRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNG----------EQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMA-SHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYF--DDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESL---YELYSQDNKRKNSADEKQQNRKSASMY----INETNGKVYLM---DAI-----GYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCGF-DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSMQVALERR 941

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Fly
Match: CG33090 (gene:FBgn0028916 transcript:FBtr0080624)

HSP 1 Score: 405.216 bits (1040), Expect = 4.235e-126
Identity = 309/938 (32.94%), Postives = 457/938 (48.72%), Query Frame = 3

Query:  102 VKLFDTRNIDEVK-VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRR-RGITVYQQVLSVHKAPEDL------------------------QSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL-NEEFFEGCSIRQKIKDMDCSYGLG--VMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESW-------------EEKIENWQKPILENSKY------PSWYK--SALFNELYF----VVDGGTVWLD-------------------------NVSVSVSLENGDSIAIARNK-HQIDYG--------------TFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNI------ADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD---ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTK-------DTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            +KL      +E+  VP+YG  +  D   P K          Q    V    RY  Y Y +  +E ++ ++D     + + IYGVP+GGIG G I RGY GEFCRF + PGIYEY    ANQFIVT++  +G T++Q +LS     +                          Q L+ W+     +R +Y GL+PR+WT YD+    ++L CRQ+SPVIPHEY++S LP  VF W+  N   +E  +SI    KNGTG     ++G   S L +E   +G SIRQKI +M CSY L   V+  ++++       +             ++LW  L  +G LS   + E    KDI +A CG+V +KPM+ SH++ FV  W MP + F      + R Y ++F  DD      ++ EYA+R   +W             +E + +W K  + N  Y        W K  S+L  EL +    +  G   +L+                         N+ VS+  +  D+IA   N   ++ Y                 G  +   + + N Y++H  + W  +     LQ    Y +      A S  +   S I +I K +L     L++  +   +  +E      + +MY      + N K  L    D I      YLK M      +M++ + +DKD DGLIEN+   DQTYD+W+  G SAY  GLWL AL ++  M+  L+   DC  + D L KGK++  +KLW GSY+++D       ++MADQLCGHWYLKSCG  D E++ ++ VRT L+ I+ NN +       GA NG + N ++       D S++Q+EE W GV YALAATM  E    EA+    G YKT+ +  G+ F+TPE+ +    +RS+GYMRPL+IW++Q AL++R
Sbjct:   36 LKLQQQEESNEIAAVPKYGLKLKFDHVWPEKRIQNVRASIRQTLPMVPLVCRYAAY-YWKVSREGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNG----------EQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMA-SHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYF--DDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESL---YELYSQDNKRKNSADEKQQNRKSASMY----INETNGKVYLM---DAI-----GYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCGF-DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSMQVALERR 943

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Fly
Match: CG33090 (gene:FBgn0028916 transcript:FBtr0343673)

HSP 1 Score: 365.925 bits (938), Expect = 7.227e-113
Identity = 251/766 (32.77%), Postives = 378/766 (49.35%), Query Frame = 3

Query:  540 QSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL-NEEFFEGCSIRQKIKDMDCSYGLG--VMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESW-------------EEKIENWQKPILENSKY------PSWYK--SALFNELYF----VVDGGTVWLD-------------------------NVSVSVSLENGDSIAIARNK-HQIDYG--------------TFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNI------ADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD---ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTK-------DTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            Q L+ W+     +R +Y GL+PR+WT YD+    ++L CRQ+SPVIPHEY++S LP  VF W+  N   +E  +SI    KNGTG     ++G   S L +E   +G SIRQKI +M CSY L   V+  ++++       +             ++LW  L  +G LS   + E    KDI +A CG+V +KPM+ SH++ FV  W MP + F      + R Y ++F  DD      ++ EYA+R   +W             +E + +W K  + N  Y        W K  S+L  EL +    +  G   +L+                         N+ VS+  +  D+IA   N   ++ Y                 G  +   + + N Y++H  + W  +     LQ    Y +      A S  +   S I +I K +L     L++  +   +  +E      + +MY      + N K  L        +    YLK M      +M++ + +DKD DGLIEN+   DQTYD+W+  G SAY  GLWL AL ++  M+  L+   DC  + D L KGK++  +KLW GSY+++D       ++MADQLCGHWYLKSCG  D E++ ++ VRT L+ I+ NN +       GA NG + N ++       D S++Q+EE W GV YALAATM  E    EA+    G YKT+ +  G+ F+TPE+ +    +RS+GYMRPL+IW++Q AL++R
Sbjct:   58 QPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNG----------EQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMA-SHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYF--DDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESL---YELYSQDNKRKNSADEKQQNRKSASMY----INETNGKVYL--------MDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCGF-DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSMQVALERR 794

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Zebrafish
Match: gba2 (glucosidase, beta (bile acid) 2 [Source:ZFIN;Acc:ZDB-GENE-070522-3])

HSP 1 Score: 639.032 bits (1647), Expect = 0.000e+0
Identity = 362/832 (43.51%), Postives = 490/832 (58.89%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKS-HEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDER----SCSVMADQLCGHWYLKSCGVPDNE--VFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR*N 2582
            VP+ GW + L      K KP+       S +   VS  +RYL + YR+ + E K PFID    V  + IYGVP+GGIG G+I RG+RGEFCR+ L PG+Y YKT  ANQF V +RR G TVYQQVLS  + P  LQ    WNW +    A Y GLFPRAWTVY++  Q + L CRQ+SPVIPH+YKDS LP+ VF W+  N     L ISI   + NG+G  D+ S G      NE F    EG S+   +             T+ ++    S   +++  + +       +W +LM++G L    +      K   +A    V     + S + + F   W MP + F      Y RRY R++           +  YA+ +   WEE IE WQ+PIL++   P+WYKSALFNELYFVVDGGT+W++   +  +S  L   D    A+ +   D+G F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY+IA S    D    L +  G      +   +PHD+GDP++EP+V++NAY +++T  WKDLN KFVLQV+RD+ + +++ YLK M P+   VM+  L +DKDGDGLIENSGYADQTYD W   G SAY GGLWL ++  +C M++ LN +  +  + D L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+L++ G+ D+E   F ++K+ + L+++F  N +S  G + GA+NG  P    D SSVQS+E WVGV Y LAATM  E    E     EG Y+ V+E  G+ FQTPE+Y + G +RSL YMRPL+IWA+Q AL+ R N
Sbjct:   25 VPKDGWRICLAHEFKEKRKPFQAKDVSLSNMLEHVSLGVRYLKWWYRKTQVEKKAPFIDMFRAVPLRQIYGVPLGGIGGGSITRGWRGEFCRWQLNPGMYHYKTVIANQFTVCLRRDGQTVYQQVLSTER-PSTLQG---WNWGYCGEHAFYHGLFPRAWTVYNLPGQNVTLTCRQVSPVIPHDYKDSSLPVAVFVWDIENKNDYALDISIMFTMVNGSGQKDDKSGG----HWNEPFHLEKEGESVSGVLLHHQTPAN---PYTLCIAARQKSGQEISHQTAFSPKGTCSAVWCDLMTDGRLDSPTNSSPPTEKGEEVAAALVVSCSVSANSRNSVDFSLAWDMPKITFGSKERTYVRRYTRYYGTKGD--AAPSISHYALTHYSKWEESIEEWQRPILQDRSLPAWYKSALFNELYFVVDGGTIWVELPEDADISGGLRPEDGGLPAQPEVVKDFGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSLQYDIAGSVVQHDPMERLNLMNGRYSPVKTRGVVPHDIGDPDDEPWVRVNAYLIHDTADWKDLNLKFVLQVYRDYHLTQDQQYLKDMWPVCQTVMENELKFDKDGDGLIENSGYADQTYDGWKVTGPSAYCGGLWLASVCMMCKMARVLNCESVYQRYRDILERGSAAFDKLLWNGKYYNYDSSGRSLSNSVMSDQCAGHWFLRASGLGDDEYQAFPKEKICSALKSVFDLNVMSFAGGQMGAVNGMRPEGVPDRSSVQSDEVWVGVVYGLAATMIHEGMVEEGLRTAEGCYRAVWERMGMAFQTPEAYCEKGIYRSLAYMRPLSIWAMQLALNNRPN 843

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Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKS-HEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDER----SCSVMADQLCGHWYLKSCGVPDNE--VFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR*N 2582
            VP+ GW + L      K KP+       S +   VS  +RYL + YR+ + E K PFID    V  + IYGVP+GGIG G+I RG+RGEFCR+ L PG+Y YKT  ANQF V +RR G TVYQQVLS  + P  LQ    WNW +    A Y GLFPRAWTVY++  Q + L CRQ+SPVIPH+YKDS LP+ VF W+  N     L ISI   + NG+G  D+ S G      NE F    EG S+   +             T+ ++    S   +++  + +       +W +LM++G L    +      K   +A    V     + S + + F   W MP + F      Y RRY R++           +  YA+ +   WEE IE WQ+PIL++   P+WYKSALFNELYFVVDGGT+W++   +  +S  L   D    A+ +   D+G F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY+IA S    D    L +  G      +   +PHD+GDP++EP+V++NAY +++T  WKDLN KFVLQV+RD+ + +++ YLK M P+   VM+  L +DKDGDGLIENSGYADQTYD W   G SAY GGLWL ++  +C M++ LN +  +  + D L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+L++ G+ D+E   F ++K+ + L+++F  N +S  G + GA+NG  P    D SSVQS+E WVGV Y LAATM  E    E     EG Y+ V+E  G+ FQTPE+Y + G +RSL YMRPL+IWA+Q AL+ R N
Sbjct:   25 VPKDGWRICLAHEFKEKRKPFQAKDVSLSNMLEHVSLGVRYLKWWYRKTQVEKKAPFIDMFRAVPLRQIYGVPLGGIGGGSITRGWRGEFCRWQLNPGMYHYKTVIANQFTVCLRRDGQTVYQQVLSTER-PSTLQG---WNWGYCGEHAFYHGLFPRAWTVYNLPGQNVTLTCRQVSPVIPHDYKDSSLPVAVFVWDIENKNDYALDISIMFTMVNGSGQKDDKSGG----HWNEPFHLEKEGESVSGVLLHHQTPAN---PYTLCIAARQKSGQEISHQTAFSPKGTCSAVWCDLMTDGRLDSPTNSSPPTEKGEEVAAALVVSCSVSANSRNSVDFSLAWDMPKITFGSKERTYVRRYTRYYGTKGD--AAPSISHYALTHYSKWEESIEEWQRPILQDRSLPAWYKSALFNELYFVVDGGTIWVELPEDADISGGLRPEDGGLPAQPEVVKDFGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSLQYDIAGSVVQHDPMERLNLMNGRYSPVKTRGVVPHDIGDPDDEPWVRVNAYLIHDTADWKDLNLKFVLQVYRDYHLTQDQQYLKDMWPVCQTVMENELKFDKDGDGLIENSGYADQTYDGWKVTGPSAYCGGLWLASVCMMCKMARVLNCESVYQRYRDILERGSAAFDKLLWNGKYYNYDSSGRSLSNSVMSDQCAGHWFLRASGLGDDEYQAFPKEKICSALKSVFDLNVMSFAGGQMGAVNGMRPEGVPDRSSVQSDEVWVGVVYGLAATMIHEGMVEEGLRTAEGCYRAVWERMGMAFQTPEAYCEKGIYRSLAYMRPLSIWAMQLALNNRPN 843

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Mouse
Match: Gba2 (glucosidase beta 2 [Source:MGI Symbol;Acc:MGI:2654325])

HSP 1 Score: 602.823 bits (1553), Expect = 0.000e+0
Identity = 345/818 (42.18%), Postives = 485/818 (59.29%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLS--GMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCD-DLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNID--CSFFADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLKSCGV--PDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIW 2549
            +VP +GW + L      K +P+       S +   +   +RYL + YR+   E K PFID +N +  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+QFIV +RR G TVYQQVLS+ + P  L+S   WNW      A Y  L+PRAWTVY +  Q + L CRQ++P++PH+Y+DS LP+ VF W+  N G E L +SI   ++NG G  D+A+  L +     E   G +++  +           M      T+  +    T    N      +++W++L+ +G L     +S   +  + I  A C    + P S+   + F   W MP + F   +  + RRY R+F  D D+    S    YA+ +   WE++I  WQ P+L++   P+WYKSALFNELYF+ DGGTVWL+  + S+    G S+   R+  Q DYG FGYLEG EYRMYNTYDVH Y+S++LV LWPKL+ S+QY++A +T   D +   Y+  G +        IPHD+GDP++EP++++NAY +++T  WKDLN KFVLQ++RD+ +  ++ +L+ M P+ L VM+  + +DKD DGLIEN GYADQTYDAW+  G SAY GGLWL A+  +  M+           FA  L +G++AY   LW G Y+ YD     +S S+M+DQ  G W+L++CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E    E +   EG Y+TV+E  GL FQTPE+Y     FRSL YMRPL+IW
Sbjct:   71 QVPPFGWRICLAHEFAEKRRPFQANNISLSNLVKHLGMGLRYLKWWYRKTHVEKKTPFIDMLNSLPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSL-ELPNVLRS---WNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQVTPILPHDYQDSSLPVGVFVWDVENEGDETLDVSITFSMRNGLGGEDDAAGSLWNEPFRLEQ-GGTTVQGLLLHHPTPPNPYTMAVAARCTADTTVTHTTAFDPNGT---GQQVWQDLLQDGQLDSPAGQSTPTQKGEGIAGAVCVSSKLLPRSRCC-LEFSLAWDMPKIMFGAKSQVHYRRYTRFFGSDGDVAPALSH---YALCHYADWEDRISAWQNPVLDDRTLPAWYKSALFNELYFLADGGTVWLEVPADSLPEGLGGSMRQLRSTLQ-DYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQGFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQQVFRSLAYMRPLSIW 875

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Mouse
Match: Gba2 (glucosidase beta 2 [Source:MGI Symbol;Acc:MGI:2654325])

HSP 1 Score: 70.8626 bits (172), Expect = 4.162e-13
Identity = 44/110 (40.00%), Postives = 66/110 (60.00%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQ 461
            +VP +GW + L      K +P+       S +   +   +RYL + YR+   E K PFID +N +  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+Q
Sbjct:   71 QVPPFGWRICLAHEFAEKRRPFQANNISLSNLVKHLGMGLRYLKWWYRKTHVEKKTPFIDMLNSLPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQ 180

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BLAST of Non-lysosomal glucosylceramidase vs. UniProt/SwissProt
Match: sp|Q9HCG7|GBA2_HUMAN (Non-lysosomal glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA2 PE=1 SV=2)

HSP 1 Score: 612.068 bits (1577), Expect = 0.000e+0
Identity = 350/820 (42.68%), Postives = 484/820 (59.02%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIA--TCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNID--CSFFADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLKSCGV--PDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIW 2549
            +VP +GW + L      K KP+       S +   +   +RYL + YR+   E K PFID IN V  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+QF V +RR G TVYQQVLS+ + P  L+S   WNW      A Y  L+PRAWTVY +  Q + L CRQI+P++PH+Y+DS LP+ VF W+  N G E L +SI   ++NG G  D+A  GL     NE F     G ++R  +           M      T++ +   +T    ++     +++W++L+ +G L     +     K + IA   C    ++P  +   + F   W MP + F      + RRY R+F  D        +  YA+     WEE+I  WQ P+L++   P+WYKSALFNELYF+ DGGTVWL+ +  S+  E G ++   R   + DYG FGYLEG EYRMYNTYDVH Y+S++L+ LWPKL+ S+QY++A +T   D +   Y+  G +        IPHD+GDP++EP++++NAY +++T  WKDLN KFVLQV+RD+ +  ++++LK M P+ L VM+  + +DKD DGLIEN GYADQTYD W+  G SAY GGLWL A+  +  M+           F+  LS+G++AY   LW G Y+ YD     +S SVM+DQ  G W+LK+CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E    E +   EG Y+TV+E  GL FQTPE+Y     FRSL YMRPL+IW
Sbjct:   80 QVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQFTVCLRREGQTVYQQVLSLER-PSVLRS---WNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDDAPGGL----WNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDST---GQQVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCR-LEFSLAWDMPRIMFGAKGQVHYRRYTRFFGQDGD--AAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLR-DYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIW 884

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BLAST of Non-lysosomal glucosylceramidase vs. UniProt/SwissProt
Match: sp|Q5M868|GBA2_RAT (Non-lysosomal glucosylceramidase OS=Rattus norvegicus OX=10116 GN=Gba2 PE=2 SV=2)

HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0
Identity = 349/822 (42.46%), Postives = 482/822 (58.64%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLS--GMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCD-DLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF------FADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLKSCGV--PDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIW 2549
            +VP +GW + L      K KP+       S +       +RYL + YR+ + E K PFID  N V  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+QFIV +RR G TVYQQVLS+ + P  L+S   WNW      A Y  L+PRAWTVY +  Q + L CRQI+P++PH+Y+DS LP+ VF W+  N G E L +SI   ++NG G  D+A+ GL +     E  +G +++  +           M      T+  +    T    ++     +++W++L+ +G L     +S   +  + +  A C    + P  +   + F   W MP + F      + RRY R+F  D D+    S    YA+     WE  I  WQ P+L++   P+WYKSALFNELYF+ DGGTVWL+    S+  E G S+   R   Q DYG FGYLEG EYRMYNTYDVH Y+S++LV LWPKL+ S+QY++A +T   D +   Y+  G +        IPHD+GDP++EP++++NAY +++T  WKDLN KFVLQV+RD+ +  ++ +LK M P+ L VM+  + +DKD DGLIEN GYADQTYD W+  G SAY GGLWL A+  +  M+    + C        F+  L +G++AY   LW G Y+ YD     +S SVM+DQ  G W+L++CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E    E +   EG Y+TV+E  GL FQTPE+Y     FRSL YMRPL+IW
Sbjct:   71 QVPPFGWRICLAHEFAEKRKPFQANNVSLSNLVKHFGMGLRYLKWWYRKTQVEKKTPFIDMFNSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSL-ELPSVLRS---WNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDETLDVSIMFSMRNGLGGEDDAAGGLWNEPFRLEQ-DGTTVQGLLLHHPTPPNPYTMAVAARHTADTTVTYTTAFDPDST---GQQVWQDLLQDGQLDSPAGQSTPTQRGEGVAGAVCASSKLLPRGRCC-LEFSLAWDMPRIMFGAKGQVHYRRYTRFFGSDGDVAPALSH---YALCQYAGWENSISAWQNPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVPEDSLPEELGGSMYQLRPILQ-DYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATFKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQGFLKDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMA----VLCGAQDVQDKFSSILCRGREAYERLLWNGRYYNYDSSSQPQSRSVMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALKTIFELNVQAFAGGAMGAVNGMQPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIW 875

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BLAST of Non-lysosomal glucosylceramidase vs. UniProt/SwissProt
Match: sp|Q69ZF3|GBA2_MOUSE (Non-lysosomal glucosylceramidase OS=Mus musculus OX=10090 GN=Gba2 PE=1 SV=2)

HSP 1 Score: 602.823 bits (1553), Expect = 0.000e+0
Identity = 345/818 (42.18%), Postives = 485/818 (59.29%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPR--FSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLS--GMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCD-DLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNID--CSFFADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLKSCGV--PDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIW 2549
            +VP +GW + L      K +P+       S +   +   +RYL + YR+   E K PFID +N +  + IYG P+GGIG G I RG+RG+FCR+ L PG+Y+++T  A+QFIV +RR G TVYQQVLS+ + P  L+S   WNW      A Y  L+PRAWTVY +  Q + L CRQ++P++PH+Y+DS LP+ VF W+  N G E L +SI   ++NG G  D+A+  L +     E   G +++  +           M      T+  +    T    N      +++W++L+ +G L     +S   +  + I  A C    + P S+   + F   W MP + F   +  + RRY R+F  D D+    S    YA+ +   WE++I  WQ P+L++   P+WYKSALFNELYF+ DGGTVWL+  + S+    G S+   R+  Q DYG FGYLEG EYRMYNTYDVH Y+S++LV LWPKL+ S+QY++A +T   D +   Y+  G +        IPHD+GDP++EP++++NAY +++T  WKDLN KFVLQ++RD+ +  ++ +L+ M P+ L VM+  + +DKD DGLIEN GYADQTYDAW+  G SAY GGLWL A+  +  M+           FA  L +G++AY   LW G Y+ YD     +S S+M+DQ  G W+L++CG+   D EVF    V   L+TIF+ N  +  G   GA+NG  P+   D SSVQS+E WVGV Y LAATM  E    E +   EG Y+TV+E  GL FQTPE+Y     FRSL YMRPL+IW
Sbjct:   71 QVPPFGWRICLAHEFAEKRRPFQANNISLSNLVKHLGMGLRYLKWWYRKTHVEKKTPFIDMLNSLPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSL-ELPNVLRS---WNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQVTPILPHDYQDSSLPVGVFVWDVENEGDETLDVSITFSMRNGLGGEDDAAGSLWNEPFRLEQ-GGTTVQGLLLHHPTPPNPYTMAVAARCTADTTVTHTTAFDPNGT---GQQVWQDLLQDGQLDSPAGQSTPTQKGEGIAGAVCVSSKLLPRSRCC-LEFSLAWDMPKIMFGAKSQVHYRRYTRFFGSDGDVAPALSH---YALCHYADWEDRISAWQNPVLDDRTLPAWYKSALFNELYFLADGGTVWLEVPADSLPEGLGGSMRQLRSTLQ-DYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQGFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQQVFRSLAYMRPLSIW 875

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. UniProt/SwissProt
Match: sp|Q7KT91|C3390_DROME (Non-lysosomal glucosylceramidase OS=Drosophila melanogaster OX=7227 GN=CG33090 PE=1 SV=1)

HSP 1 Score: 405.216 bits (1040), Expect = 4.245e-125
Identity = 309/938 (32.94%), Postives = 457/938 (48.72%), Query Frame = 3

Query:  102 VKLFDTRNIDEVK-VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRR-RGITVYQQVLSVHKAPEDL------------------------QSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL-NEEFFEGCSIRQKIKDMDCSYGLG--VMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESW-------------EEKIENWQKPILENSKY------PSWYK--SALFNELYF----VVDGGTVWLD-------------------------NVSVSVSLENGDSIAIARNK-HQIDYG--------------TFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNI------ADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD---ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTK-------DTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            +KL      +E+  VP+YG  +  D   P K          Q    V    RY  Y Y +  +E ++ ++D     + + IYGVP+GGIG G I RGY GEFCRF + PGIYEY    ANQFIVT++  +G T++Q +LS     +                          Q L+ W+     +R +Y GL+PR+WT YD+    ++L CRQ+SPVIPHEY++S LP  VF W+  N   +E  +SI    KNGTG     ++G   S L +E   +G SIRQKI +M CSY L   V+  ++++       +             ++LW  L  +G LS   + E    KDI +A CG+V +KPM+ SH++ FV  W MP + F      + R Y ++F  DD      ++ EYA+R   +W             +E + +W K  + N  Y        W K  S+L  EL +    +  G   +L+                         N+ VS+  +  D+IA   N   ++ Y                 G  +   + + N Y++H  + W  +     LQ    Y +      A S  +   S I +I K +L     L++  +   +  +E      + +MY      + N K  L    D I      YLK M      +M++ + +DKD DGLIEN+   DQTYD+W+  G SAY  GLWL AL ++  M+  L+   DC  + D L KGK++  +KLW GSY+++D       ++MADQLCGHWYLKSCG  D E++ ++ VRT L+ I+ NN +       GA NG + N ++       D S++Q+EE W GV YALAATM  E    EA+    G YKT+ +  G+ F+TPE+ +    +RS+GYMRPL+IW++Q AL++R
Sbjct:   36 LKLQQQEESNEIAAVPKYGLKLKFDHVWPEKRIQNVRASIRQTLPMVPLVCRYAAY-YWKVSREGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNG----------EQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMA-SHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYF--DDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESL---YELYSQDNKRKNSADEKQQNRKSASMY----INETNGKVYLM---DAI-----GYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCGF-DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSMQVALERR 943

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BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
Match: T1JDY2 (Non-lysosomal glucosylceramidase OS=Strigamia maritima OX=126957 PE=3 SV=1)

HSP 1 Score: 737.643 bits (1903), Expect = 0.000e+0
Identity = 385/823 (46.78%), Postives = 519/823 (63.06%), Query Frame = 3

Query:  138 KVPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEE----FFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNK--DILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNID--CSFFADALSKGKKAYVDKLWTGSYFKYDERSCS----VMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYAL 2567
            K  ++GW V LD     K   Y  PR  Q+   +  + RY  + Y + ++  +KPFID +  +  Q +YGVP+GGIG+G I RG++GEFCRF LIPG+Y+++T  A+QFIV +RR G TVYQ+VLS  K  ++L+S   W W F  S+A+Y GL+PRAW  YDI E+KI+L CRQ+SPVIP+EYKDS LP+ VF W   N G E   +SI    KNGTG   +   G  + +  E       +G  + Q I+DM+C+  +   +  NV  S            N    G  ++W++LM +G L+  K K  +  K  +I  A   +  V  +     +RF  VW MP + F+ N V++RRRY  WF   D     S +  YA+ NV  WE  IE WQ PIL NS  P+WYKSALFNELY++ DGG+VWL + + S+S +        R   + ++G F YLEGHEYRMYNTYDVH Y+S++L  LWPKLQ S+QY+I D+T S D     ++  G    R S+ ++PHD+GDPEEEP++ +N+Y +++T +WKDLN KFVLQV+RD+   K+EDYL+ M P V  +M KC+S+D DGDGLIENSG ADQTYD WI KG+SAY GGLWL AL     M++ L  +   + + + L K K+AY  KLW  +Y+K+D+R+ S    +M+DQLCGHWYLK+ GV + EVF  + V+ TL+TI+ NN +   G K GA+NG LP+   D  SVQSEE WVGV YALAATM  E    E     +G Y T+Y+  GL FQTPE+ +   + RSLGYMRPL+IWA+Q+AL
Sbjct:    9 KSDEHGWKVQLDHEFTEKRNQYLRPRLKQLPDLIGMSFRYFLW-YLKMRRLKRKPFIDGMKCLPVQQMYGVPLGGIGAGTIGRGFKGEFCRFQLIPGVYKHRTVKADQFIVCIRRNGTTVYQKVLSPLKPKKELKS---WVWGFDGSQASYRGLYPRAWYTYDIPEEKIRLVCRQVSPVIPNEYKDSSLPVAVFTWTVYNLGDESAEVSIAFAFKNGTGGARDKDGGCWTEAFGESQNTLVAKGVLMHQIIRDMNCTVAISAAEDENVKVSHLVEF-------NPKGNGA-DVWDDLMEDGHLNSSKDKSERTRKGEEIASAVAAQCCVDGLGNG-VMRFCLVWDMPTIWFKGNAVKHRRRYTNWF---DKIQNASSLSVYALANVSKWENLIEEWQNPILNNSSLPNWYKSALFNELYYISDGGSVWLKSNAQSISQKES-----LRGDVRPEFGQFAYLEGHEYRMYNTYDVHFYASFALAMLWPKLQLSLQYDIMDATLSEDRRNTKFLMNGHTGLRKSINSVPHDIGDPEEEPWLSLNSYFVHDTTEWKDLNTKFVLQVYRDYTFTKDEDYLRNMWPTVKILMAKCMSFDVDGDGLIENSGSADQTYDTWIMKGSSAYCGGLWLAALCVTTLMARKLGDEAIATNYHEVLEKAKQAYNKKLWNDTYYKFDDRNNSSSFCIMSDQLCGHWYLKASGVTE-EVFPLENVKKTLKTIYDNNVMKFKGGKMGAVNGMLPSGIVDLVSVQSEEVWVGVTYALAATMLHEGMFEEGMNTAKGMYTTIYDQLGLGFQTPEAIYAEKNCRSLGYMRPLSIWAVQWAL 809

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
Match: A0A1S3HY00 (Non-lysosomal glucosylceramidase OS=Lingula unguis OX=7574 GN=LOC106159236 PE=3 SV=1)

HSP 1 Score: 735.332 bits (1897), Expect = 0.000e+0
Identity = 375/838 (44.75%), Postives = 511/838 (60.98%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRY-LFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVH--KAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGL----ISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMK--SKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIAR----------NKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD----ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSL--GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQ 2573
            VP YGW V LD       KP+  PR  Q+   V  ++RY LF++  +K++E K+ FID +  V +QPIYG P+GGIG G I RG++GEFCRF ++PGIY++    ANQF V VRR+G TVYQQVLS H  K P     L  WNW F    A Y  L+PR+WT YD+  Q I+L CRQ+SPV PH+YKD+ LP   F W+  N G E + +SI    KNG G+ ++   G+      S+ N     G  I Q  K+M C+Y +       V  S   S    +   N        +W +L+ +G+L      S +    +++  A C K  VKP S + ++ F   W MP+++F      Y RRY RWF        +  +  + + N   WE+KI+ WQKPI++N   P WYKSALFNELYFV DGGTVW+D ++     ++  +    R          N  + +YG FGYLEG EYRMYNTYDVH+Y+S++L+ LWPKLQ S+QY++A      D +   +   G ++   +   +PHDVGDPE+EP+++ N Y ++ T  WKDLNPKFVLQV+RD+ + K+  Y+K M P    V   CL +D DGDGLIEN G+ADQTYD+W   GASAY GGLWL +L+ +C M++ L    D   + + L KGK ++  KLW G Y+ YD    + S S+MADQLCGHWYLK+ GV D+ +F  D V+T LR+I++ N +    GT  GA+NG  P+   DT +VQSEEFW GVNYALAA+M  E    E + + +G Y T+YE++GL FQTPE+YF+   +RSLGYMRPL+IWA+Q+AL++
Sbjct:   21 VPDYGWRVKLDHEFQEDIKPFVTPRLRQVAPLVGLSLRYGLFWL--KKRREGKRIFIDQVKVVPYQPIYGAPVGGIGCGTIGRGFKGEFCRFQMVPGIYQWHVVEANQFTVCVRRKGQTVYQQVLSPHRPKGP----GLTAWNWAFHGEYATYHALYPRSWTAYDLPGQNIRLICRQVSPVFPHDYKDTSLPAAAFIWSIENQGSEPVDVSIMFTFKNGQGIREDKKGGVWNEPFESTHNATKVSGVMIHQTFKEMGCTYAVAASHREGVHVSHKVSFDPNSPAVN--------VWRDLLEDGELDSCPDPSPKTSRGQELATAVCAKCHVKPQS-TQQMDFSLTWDMPVIYFGAKEQLYCRRYTRWFGSSGN--ASPHLASHTLNNYHIWEKKIDEWQKPIVQNRHLPDWYKSALFNELYFVSDGGTVWVDKMAHKNGFQDSKADTPPRVEDAQKDVRDNPLEQEYGKFGYLEGQEYRMYNTYDVHYYASFALIMLWPKLQLSLQYDLAMDIPREDLTRFKFCMDGNVDVVKAKNCVPHDVGDPEDEPWIRTNCYAIHATHDWKDLNPKFVLQVYRDYHITKDHAYMKSMYPCAKAVTDSCLRFDHDGDGLIENGGFADQTYDSWSMTGASAYCGGLWLASLHLMCLMARQLGYYGDEKKYKEILDKGKISFERKLWNGQYYNYDSAGKKHSDSIMADQLCGHWYLKASGVADDTIFPADHVKTALRSIYKYNVLPFKNGT-MGAVNGARPSGKADTCAVQSEEFWTGVNYALAASMIQEGMLEEGFKVAQGAYHTLYESWGLGFQTPEAYFENNRYRSLGYMRPLSIWAMQWALEK 840

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
Match: K1R968 (Non-lysosomal glucosylceramidase OS=Crassostrea gigas OX=29159 GN=CGI_10024790 PE=4 SV=1)

HSP 1 Score: 733.791 bits (1893), Expect = 0.000e+0
Identity = 372/827 (44.98%), Postives = 519/827 (62.76%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEF----FEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLS--GMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQI---DYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYDERSC----SVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQ 2573
            +P +GW V L++   +KCKP+T PRFSQ+ GF+   IRY    ++R++ + +K FID ++ +  + IYG P+GGIG G + RGYRGEF RF ++PGIY++    ANQFI+ +R+ G TVYQ+VL+  +  E  +SL  W WQ P     Y  L+PR+WTVY + E  ++L CRQ+SP+ PH+YKD+  P+  F W A N G E L +SI    KNG G+ D+ + G  +   +E        G SI   I+DM C+Y +G +   +VS +         T         +E+WE+L  +G L+  G K+      ++   A C K  V P  +  ++ F   W MP++HF+     Y RRY+RWF  D       +M  YA  N  +WE+KIE WQKP+L+N   P+WYKSALFNELY+V DGGTVW+D     V  + G  + +   K      ++  FGYLEGHEYRMYNTYDVHHY+S+SL+ LWPKLQ S+QY+IA + +S DS+ I ++  G +  R  L A+PHD+GDPE+EP+ ++N Y ++ T  WKDLN KFVLQ +RD+   K++ YL++M P+   VM+    WD D DG+I+N G+ADQT+DAW   GASAY GG+WL AL  +  M+  L    D   + + L KGK +Y +KLW GSY+ YD  S     S+MADQL GHW+LK+ G+ D+++F  D+V+++L+ IF+NN +   G   GAING  P+ +KD SS QSEEFWVGV Y LAA M  E   ++A+    G Y   +E YGL FQTPE+Y     +RSLGYMRPLAIW++Q+AL++
Sbjct:  648 IPDFGWRVNLNYECGIKCKPFTQPRFSQVIGFIGLGIRYAKEWWKRRR-QGRKMFIDHMDQLFHKAIYGAPIGGIGCGTMGRGYRGEFARFQMVPGIYDHTVIQANQFILCIRKNGQTVYQKVLTGQR--ESSKSLRSWEWQAPREGDVYHALYPRSWTVYHLDEFNLRLICRQVSPIFPHDYKDTSFPMATFIWTAENNGTEPLDVSIMFTFKNGRGVKDDGNGGCHNHVFDENSEGRQVSGVSINHNIQDMKCTYCIGGVHKDDVSVTCKEYFDPRGTG--------QEVWEDLKEDGQLNTEGGKTTCTGKGEESAAAVCVKANVPP-KQCKDLEFTLTWDMPIIHFKAKERFYARRYSRWFGLD--GEAGPRMSSYAAANYSTWEQKIEEWQKPVLQNKNLPAWYKSALFNELYYVSDGGTVWID----PVEGQGGKLVRVTDPKDPPIVQEFSRFGYLEGHEYRMYNTYDVHHYASFSLIMLWPKLQISLQYDIATAVESEDSTRIKFLTSGEVGIRKRLHAVPHDMGDPEDEPWNRVNCYVIHPTCNWKDLNMKFVLQTYRDYSATKDDAYLRHMYPVAKYVMETAKKWDVDDDGIIDNGGFADQTFDAWTMTGASAYCGGMWLAALRMMIEMATILKKEDDVLHYKEILDKGKVSYQNKLWNGSYYNYDCSSGGHHDSIMADQLAGHWFLKASGLQDDDIFPPDRVKSSLKKIFENNVMMFEGGNMGAINGTRPDGSKDISSCQSEEFWVGVTYGLAANMIQEGLLDQAFQTAWGAYHVCWEWYGLAFQTPEAYMTDNIYRSLGYMRPLAIWSMQWALEK 1456

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
Match: A0A0L8HXG2 (Non-lysosomal glucosylceramidase OS=Octopus bimaculoides OX=37653 GN=OCBIM_22003313mg PE=3 SV=1)

HSP 1 Score: 702.975 bits (1813), Expect = 0.000e+0
Identity = 379/830 (45.66%), Postives = 511/830 (61.57%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGL------ISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKE-LWENLMSNGDLSGM------KSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVS-VSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHL-NIDCSF-FADALSKGKKAYVDKLWTGSYFKYD----ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYAL 2567
            VP +GW V L ++  +KCK +  PR  QI  ++   +RY   ++ RK KE K+PFID +N +++QPIYG P+GGIG G I RGY+GEFCRF LIPG Y++ T  A+QFIV +R+R  TVYQ+VLSV K   D + LNCW W      A Y  L+P +WT+YDI E  ++L CRQ+SP+ PHEY+D+ LP  VF W A N G+E+L +SI    KNG G+ ++ + G       +S+    E   G  I Q  +DM C YG+ V    ++S S C            +  GP E +W++L  +G L+        KS+  K N +  +  C K  V     S ++ F   W MP +HF+     YRRRY RWF          Q+  YA+ N ++WE+KIE WQ  +L+N+  P+WYKSALFNELY+V DGGTVWLD V  S +S E  + I         ++G F YLEGHEYRMYNTYDVH Y+S++L+ LWPKLQ  +QY+ A +    D +++ Y+  GT     S  +IPHD+GDPE+EP+V++N Y ++ T  WKDLN KF+LQVFRD+  LK+  YLK M P V  +M +   WDKDGDGLIEN G+ADQT+DAW A GASAY GG+WL AL     M+K L + D    F + L +GK+++  KLW G Y+ YD        S+MA QL G W++++ G+ D+ VF   KVR+ L  I+++N + L     GAING   +  KDT++ Q+EEFWVG+ Y+LAATM  E    E +    G Y   +E  GL FQTPE+Y     +RSLGYMRPLAIW+IQ+AL
Sbjct:   45 VPDFGWRVPLSYSCQMKCKAFFTPRLKQIPSYLGLGVRYC-KLWMRKHKEGKRPFIDHMNALAYQPIYGAPIGGIGCGTIGRGYQGEFCRFQLIPGCYDHTTVLADQFIVCIRKRNKTVYQEVLSVKKP--DNKCLNCWKWNLDPDHAIYHALYPHSWTIYDIPEHNVRLTCRQVSPIFPHEYQDTSLPCAVFVWTAENLGEEDLEVSIMFTFKNGRGVKEDKAGGCWNEYFHVSNDSPSEPVSGVQIHQSFRDMPCVYGIAVKHKPDLSVSHCVYF---------DPCGPGEDIWQDLYEDGSLTKSEADLESKSEPTKKNSECAVGVCCKCAVASGGPSKQMEFSLSWDMPNIHFKSKGQNYRRRYTRWF--GHTAQAAPQLCSYALNNYKTWEQKIEAWQNTVLQNNDLPAWYKSALFNELYYVSDGGTVWLDPVPNSDLSSETKEEIPAVIQ----EFGKFAYLEGHEYRMYNTYDVHFYASFALLTLWPKLQLCLQYDFAKAIDQEDPTIVEYLMCGTKGPNKSPKSIPHDLGDPEDEPWVRVNTYNLHPTHDWKDLNLKFILQVFRDYYALKDLQYLKDMYPKVKNIMTEAQKWDKDGDGLIENGGFADQTFDAWTATGASAYCGGIWLAALRLTVEMAKILEDRDTEIKFTEILHEGKESFDKKLWNGLYYNYDCSDKPYHDSIMAAQLIGQWFIRASGIQDDLVFPSQKVRSVLNVIYEHNVMKLNNGNCGAINGGRLDCMKDTTNCQAEEFWVGIIYSLAATMIQEGMSKEGFQTAWGAYHMCWEVLGLSFQTPEAYTLDNVYRSLGYMRPLAIWSIQWAL 856

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
Match: V4B001 (Non-lysosomal glucosylceramidase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_237752 PE=3 SV=1)

HSP 1 Score: 690.263 bits (1780), Expect = 0.000e+0
Identity = 374/822 (45.50%), Postives = 503/822 (61.19%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGP-KELWENLMSNGDLSGMKSKEM---KHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQI--DYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYD----ERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYAL 2567
            VP +GW V L +  P KC P+  PR SQI  ++  ++RY   ++ +KKKE KKPFID +N +   PIYG P+GGIG G I RGY+GEFCRF +IPGIY + T  A+QFIV +RR G+TVYQQVLS     +  +SL  W+W FP   A Y  L+PRAWTVYDI +  +KL CRQISP+ PHEY+++ LP  VF W   N G E+L  SI    +NG G  ++ ++G+ S    ++   G SI Q    M C+Y L  +   +V  S+           N +  G  +ELW +L  +G L    +         KDI +A C  + V  MS S  + F   W MP++ F      Y RRY RWF  +        + ++A++N   WE+KI +WQ+P+L + K P WYKSAL+NELY++ DGGTVWLD   +  + +         N H +  +Y  FGYLEG EYRMYNTYDVHHY+S++L+ LWPKLQ S+QY++A +    D + + Y+  G          +PHD+GDPEEEP+ K+N Y+++ T  WKDLN KFVLQV+RD++   +  YL  M P+ + V++  + WD DGDGLI+NSGYADQT+DAW  KGASAY GGLWL AL  +C M   L    D   +A  L +G ++Y DKLW G Y++YD    E   S+MADQL G WYL +  + D  VF  D+V+T L+T+++NN    G    GAING  P+ ++DTSS QSEEFW G+ YA+AA+M  E   +E      G Y   +E  GL FQTPE+Y     +RSLGYMRPL+IWAIQ+A+
Sbjct:   21 VPDFGWRVKLSYECPDKCSPFFKPRVSQIPQYMGLSMRYSA-MWMKKKKEGKKPFIDHMNAIKHNPIYGCPIGGIGCGTIGRGYKGEFCRFQMIPGIYRHHTVEADQFIVCIRRNGVTVYQQVLSSQV--KKGKSLKNWSWGFPGGSATYHALYPRAWTVYDIKKHNVKLICRQISPIYPHEYQETSLPTAVFVWTIENNGPEDLEASITFTFQNGQGSKNDCNKGISSGEFQKQDLTGVSIHQLFNGMKCTYSLASISKPDVDISTVV---------NFDPHGSGEELWNDLYEDGKLGNTPAASPATGNKGKDIGVAVCAFINVPSMS-SKSLDFALAWDMPVIQFGAKEQHYARRYTRWFGTEGN--AGPNLCQHALKNYPMWEKKINDWQQPVLNSKKLPGWYKSALYNELYYISDGGTVWLDPHELDKNFK------ADINLHPVVKEYSRFGYLEGMEYRMYNTYDVHHYASFALIMLWPKLQLSLQYDMAATIVRNDETNMQYLMSGEKGPTHIANTVPHDIGDPEEEPWKKVNCYSIHPTHDWKDLNTKFVLQVYRDYVATNDRKYLHEMYPVAVGVIEHAIDWDTDGDGLIDNSGYADQTFDAWTMKGASAYCGGLWLAALRVLCEMGFILGKTDDVDRYAAILKRGAESYQDKLWNGKYYEYDSSNSEHHDSIMADQLSGQWYLHASDIKDEAVFPSDRVKTALKTVYENNVKKFGNGNMGAINGTKPDGSRDTSSPQSEEFWTGITYAVAASMIQEGLLDEGLQTAYGAYHACWEGLGLAFQTPEAYTTEKGYRSLGYMRPLSIWAIQWAI 821

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Cavefish
Match: gba2 (glucosylceramidase beta 2 [Source:NCBI gene;Acc:103034502])

HSP 1 Score: 614.379 bits (1583), Expect = 0.000e+0
Identity = 352/832 (42.31%), Postives = 485/832 (58.29%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKE-----LWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVK-PMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDER----SCSVMADQLCGHWYLKSCGVPDNE--VFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            VP+ GW + L      K KP+       S I   V+  +RYL + Y++ + E K PFID    V  + IYG P+GGIG G I RG++GEFCR+ L PG+Y YKT  A+QF V +R+ G TVYQQVLS  + P  LQ    WNW F    A Y  L+PRAWTVY +  Q + L CRQ+SPVIPH+YKDS LP+ VF W+  N     L +SI   + NG+G  D+ S G      NE F       +K  +      L    TVN  T   ++   ++   +       E     LW +L+++G L           K   +A    V    P    + I F   W MP + F     ++ RRY R++  +     T  +  YA+ + + WE+ IE WQ+P+LE+S  PSWYKSA+FNELYFV DGGTVW++   +  +S  L + +    A+     +YG F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY++A S    D +    +  G      +   +PHD+GDP++EP++++NAY +++T  WKDLN KFVLQV+RD+ + ++  YL+ M PI   VM+  + +DKDGDGLIENSGYADQTYD W   G SAY GGLW+ ++  +C M++ L  D  +  +   L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+L++ G+ ++E   F ++K+R+ L+++F  N +S G  + GA+NG  P    D SSVQS+E WVGV Y LAATM  E    E     EG Y+TV+E  G+ FQTPE+Y + G +RSL YMRPL+IWA+Q ALD R
Sbjct:   25 VPKDGWRICLAHEFKEKRKPFQAKDVSVSNIMKHVALGVRYLKWWYKKTQVEKKAPFIDMFRAVPLRQIYGAPLGGIGGGTITRGWKGEFCRWQLNPGMYHYKTVIADQFTVCLRKGGQTVYQQVLSTER-PHTLQG---WNWGFCGEYAFYHALYPRAWTVYQLPGQNVTLTCRQVSPVIPHDYKDSSLPVAVFVWDIENKNDYALDVSIMFTMVNGSGQKDDKSGG----HWNEPFH-----LEKESETVSGVLLHHCTTVNPYTLCMAARKQSDREISHQTAFSPEGTCSALWSDLINDGRLDSPAGSSPPTQKGERVAAALAVGCPVPAHGHNSIEFSLAWDMPKMTFGSREKEHIRRYTRYYGTNGDAGPT--LSHYALTHYKDWEKSIEEWQRPVLEDSSLPSWYKSAIFNELYFVADGGTVWVEIPEDCDISGGLRSEEGGLPAQPPIVKEYGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSLQYDLAGSVVQQDPTPRTNLMTGQCTAVKTRNVVPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYHLTQDSQYLQDMWPICQAVMETEMKFDKDGDGLIENSGYADQTYDGWPVTGPSAYCGGLWIASVCVMCKMAQILKNDSVYERYHSILERGSAAFDKLLWNGKYYNYDSSGQSLSNSVMSDQCAGHWFLRASGLGNDEFQAFPKEKIRSALKSVFDLNVMSFGKGQLGAVNGMRPEGVPDHSSVQSDEVWVGVVYGLAATMIHEGMLEEGLHTAEGCYRTVWERAGMAFQTPEAYCEKGIYRSLAYMRPLSIWAMQLALDNR 841

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Cavefish
Match: gba2 (glucosylceramidase beta 2 [Source:NCBI gene;Acc:103034502])

HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0
Identity = 350/832 (42.07%), Postives = 484/832 (58.17%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKE-----LWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVK-PMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDER----SCSVMADQLCGHWYLKSCGVPDNE--VFDQDKVRTTLRTIFQNNCVSLGT-KFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            VP+ GW + L      K KP+       S I   V+  +RYL + Y++ + E K PFID    V  + IYG P+GGIG G I RG++GEFCR+ L PG+Y YKT  A+QF V +R+ G TVYQQVLS  + P  LQ    WNW F    A Y  L+PRAWTVY +  Q + L CRQ+SPVIPH+YKDS LP+ VF W+  N     L +SI   + NG+G  D+ S G      NE F       +K  +      L    TVN  T   ++   ++   +       E     LW +L+++G L           K   +A    V    P    + I F   W MP + F     ++ RRY R++  +     T  +  YA+ + + WE+ IE WQ+P+LE+S  PSWYKSA+FNELYFV DGGTVW++   +  +S  L + +    A+     +YG F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY++    +  D +    +  G      +   +PHD+GDP++EP++++NAY +++T  WKDLN KFVLQV+RD+ + ++  YL+ M PI   VM+  + +DKDGDGLIENSGYADQTYD W   G SAY GGLW+ ++  +C M++ L  D  +  +   L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+L++ G+ ++E   F ++K+R+ L+++F  N +S G  + GA+NG  P    D SSVQS+E WVGV Y LAATM  E    E     EG Y+TV+E  G+ FQTPE+Y + G +RSL YMRPL+IWA+Q ALD R
Sbjct:   45 VPKDGWRICLAHEFKEKRKPFQAKDVSVSNIMKHVALGVRYLKWWYKKTQVEKKAPFIDMFRAVPLRQIYGAPLGGIGGGTITRGWKGEFCRWQLNPGMYHYKTVIADQFTVCLRKGGQTVYQQVLSTER-PHTLQG---WNWGFCGEYAFYHALYPRAWTVYQLPGQNVTLTCRQVSPVIPHDYKDSSLPVAVFVWDIENKNDYALDVSIMFTMVNGSGQKDDKSGG----HWNEPFH-----LEKESETVSGVLLHHCTTVNPYTLCMAARKQSDREISHQTAFSPEGTCSALWSDLINDGRLDSPAGSSPPTQKGERVAAALAVGCPVPAHGHNSIEFSLAWDMPKMTFGSREKEHIRRYTRYYGTNGDAGPT--LSHYALTHYKDWEKSIEEWQRPVLEDSSLPSWYKSAIFNELYFVADGGTVWVEIPEDCDISGGLRSEEGGLPAQPPIVKEYGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSLQYDLGKCLQ--DPTPRTNLMTGQCTAVKTRNVVPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYHLTQDSQYLQDMWPICQAVMETEMKFDKDGDGLIENSGYADQTYDGWPVTGPSAYCGGLWIASVCVMCKMAQILKNDSVYERYHSILERGSAAFDKLLWNGKYYNYDSSGQSLSNSVMSDQCAGHWFLRASGLGNDEFQAFPKEKIRSALKSVFDLNVMSFGKGQLGAVNGMRPEGVPDHSSVQSDEVWVGVVYGLAATMIHEGMLEEGLHTAEGCYRTVWERAGMAFQTPEAYCEKGIYRSLAYMRPLSIWAMQLALDNR 859

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Sea Lamprey
Match: gba2 (glucosidase, beta (bile acid) 2 [Source:ZFIN;Acc:ZDB-GENE-070522-3])

HSP 1 Score: 642.884 bits (1657), Expect = 0.000e+0
Identity = 369/855 (43.16%), Postives = 505/855 (59.06%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLPRFS--QIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQ---------FIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIP-----GPK----ELWENLMSNGDLSGMK--SKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVS---------VSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFA---DALSKGKKAYVDKLWTGSYFKYDER----SCSVMADQLCGHWYLKSCGVPDN--EVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            VP  GW + L      K KP+ L   S  Q+ GF    +RYL++  ++K+ E K PFID  +    + IYGVP+GGIG G I RG++GEFCR++L PG+Y Y+T +A+Q         F V VRR G T YQQVLS    P+   SL  WNW F    A Y  L+PRAWTVY++  Q I L CRQISPVIP++YKDS LP  VF W+  N+G+E++ ++I   + N  G   +  +G      NE F    +  +   D   S   GV+   N  T+  +       ++   +       PK    E+W +LM +G L+  +  SK  +  +++  A    V V     S ++ F   W MP + F+    +Y RRY RWF  D       ++  YA+   + WEE IE WQ PIL+++  P+WYKSA+FNELYFV DGGTVW++  +           V   NG S  +  N+  ++YG F YLEG EYRM+NTYDVH Y+S++L+ LWP+LQ S+QY+IA +  + D+    ++  G+     +   +PHDVGDP +EP+V++NAY +++T  W+DLN KFVLQV+RD+    +  YL  + P+   VM   L +D DGDGLIENSG ADQTYD W  KGASAY GG+WL    SVC M K  +I  D + F    D LS+GKKA+  KLW G Y+KYD      S SVM+DQ  G WYL +  + D   E F +D+V++ LRTI+  N +   G   GA+NG +PN T DT+SVQS E WVGV Y+LAATM  E    E +   EGTY+TV+E  G+ FQTPE+Y +   FRSL YMRPL++W++Q+AL++R
Sbjct:   14 VPDDGWRICLKHEFTEKRKPFHLQNISPKQVIGFFGMGLRYLWFYQKKKRVEKKAPFIDLFDSQPLRQIYGVPLGGIGGGCITRGWKGEFCRWNLQPGLYAYETISADQQVGNCECRYFTVCVRRNGQTTYQQVLS----PDQPHSLQNWNWGFCGRFAYYHALYPRAWTVYELPGQGITLTCRQISPVIPNDYKDSSLPTGVFVWDIENHGEEDVEVAIMFTMSNSAGRKHDGKEG----HWNEPFH---TAGEGASDGAVS---GVLLHHNHPTNPYTMAIAAQHQAGVTVSHLTEFDPKGLGAEVWTDLMQDGRLNSPQGPSKPTRSRQEVAAAVASTVSVMARG-SAQVEFCLAWDMPKMRFKSKEREYCRRYTRWFGTDGQ--AAPKLCLYALSRYKEWEENIEAWQSPILKDTSLPAWYKSAVFNELYFVTDGGTVWVEARTEEAPKGCDDDDVRPMNGTS-PLPCNETLLEYGRFAYLEGQEYRMFNTYDVHFYASFALIMLWPQLQLSLQYDIASAILAEDTQQRTHLMNGSRSNVKTKHVVPHDVGDPYDEPWVRLNAYLIHDTRDWRDLNLKFVLQVYRDYHATGDRRYLDRLWPVCKIVMNSELEFDADGDGLIENSGAADQTYDGWAVKGASAYCGGMWLA---SVCTMRKMADIMGDLTCFNKYDDILSRGKKAFETKLWNGRYWKYDSSGELYSASVMSDQCAGQWYLGASNLGDGEYEAFPKDQVQSALRTIYDLNVMKFSGGTMGAVNGMMPNGTVDTTSVQSIEVWVGVVYSLAATMIQEGLTEEGFKTAEGTYRTVWERLGMAFQTPEAYCEQDVFRSLAYMRPLSVWSMQWALERR 847

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Nematostella
Match: EDO31657 (Non-lysosomal glucosylceramidase [Source:UniProtKB/TrEMBL;Acc:A7SX93])

HSP 1 Score: 596.275 bits (1536), Expect = 0.000e+0
Identity = 332/787 (42.19%), Postives = 459/787 (58.32%), Query Frame = 3

Query:  276 RKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDL--QSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKI---KDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSH-EIRFVFVWHMPLVHFRDNTVQYRRRYARWF-HCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNI--DCSFFADALSKGKKAYVDKLWTGSYFKYDERSC----SVMADQLCGHWYLKSCGVP---DNEVFDQDKVRTTLRTIFQNNCVSL--GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR*N 2582
            ++KK  + P+ID +     + +YGVP+GGIG G I RG+RGEF R+ L PGIY Y    ANQF+V VR++G T YQ VLS ++    L  +SL  WNW F  S A Y  L+PRAWT Y++  Q I L CRQ+SPV PH+YKD+ LP+ VF W+  N   EE+ +SI    +NG G  D  +     S+        C +   +   K     Y L +                T T  ++  P  + +W +LM +G L+           D  +           ++S  E+ F   W MP+++F ++  ++ R Y R+F H  +       +  +A+ +   WE KIE WQKPIL++   P+WYKSALFNELYFV DGGTVWLD     V  E+G S   A    +I  G F YLEGHEYRMYNTYDVH Y+S++L  LWPKLQ S+QY++A +    D+ +++ +  G    +     IPHD+GDP E P+  +NAY +++T +WKDLN KFVLQV+RD++   +  YL+ M PI   VM K +++D DGDGLIENSG ADQT+DAW   G SAY GGLWL AL  +  ++  L+   +   +   L++GKKAY   LW G Y+ YD  +     S+MADQL G WYL +C +    ++ VF  + V + LRT+F  N +    GT  GA+NG  P+   DTSS+Q+EE W GV YA+AA+M  E   +E +    G Y T +E  G+ FQTPE+    G++RSL YMRPL+IWA+Q+AL++R N
Sbjct:    6 KEKKNGRVPYIDPLAANPCRQVYGVPLGGIGCGTIGRGWRGEFNRWQLTPGIYSYNYVEANQFVVCVRKKGRTTYQAVLSPNRPNGVLCGRSLQGWNWGFSGSNAVYHALYPRAWTRYELPGQDIILVCRQVSPVFPHDYKDTSLPVAVFIWSIENNNNEEVEVSIMFSFENGDGTQDLTAGHYNESADTTGSNTTCDVTGVLLHHKHHKLPYTLAI--AAKALHKKELVTVTTKTWFDSRTPC-RRVWNDLMDDGKLNSSTEPSPPSRSDQSLCAAVAATTTVAARSRGELEFALAWDMPVIYFGNSKKRHYRYYTRYFGHQGN---AGPALCSHALMSYPDWETKIEAWQKPILQDESLPNWYKSALFNELYFVADGGTVWLD-----VRSESGTSKGTADIVRKI--GRFAYLEGHEYRMYNTYDVHFYASFALAMLWPKLQLSLQYDMAHAVNVSDNQVVMTMMNGHYCRKKVPGCIPHDIGDPSEAPWDHVNAYHIHDTSKWKDLNLKFVLQVYRDYVFTNDVYYLQDMWPITKTVMTKSMTYDSDGDGLIENSGLADQTFDAWPVTGPSAYCGGLWLAALRVMAEIATILDFPDERGKYEKILARGKKAYERLLWNGKYYNYDSSTSKYHNSIMADQLSGQWYLHACDLAQTSNDRVFPSENVISALRTVFNFNVMKFQEGT-MGAVNGIRPDGQLDTSSLQAEEVWTGVTYAVAASMIQEGLVDEGFKTASGIYNTCFERLGMNFQTPEAIVANGNYRSLAYMRPLSIWAMQWALEKRKN 778

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Nematostella
Match: EDO27312 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9L2])

HSP 1 Score: 109.383 bits (272), Expect = 1.542e-27
Identity = 49/98 (50.00%), Postives = 67/98 (68.37%), Query Frame = 3

Query: 2289 FGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR*N 2582
             GA+NG  P+   DTSS+Q+EE W GV YA+AA+M  E   +E +    G Y T +E  G+ FQTPE+    G++RSL YMRPL+IWA+Q+AL++R N
Sbjct:   54 MGAVNGIRPDGQLDTSSLQAEEVWTGVTYAVAASMIQEGLVDEGFKTASGIYNTCFERLGMNFQTPEAIVANGNYRSLAYMRPLSIWAMQWALEKRKN 151

HSP 2 Score: 53.9138 bits (128), Expect = 2.939e-8
Identity = 25/51 (49.02%), Postives = 36/51 (70.59%), Query Frame = 3

Query: 1722 EEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLE 1874
            E P+  +NAY +++T +WKDLN KFVLQV+RD++   +  YL+ M PI  E
Sbjct:    1 EAPWDHVNAYHIHDTSKWKDLNLKFVLQVYRDYVFTNDVYYLQDMWPITKE 51

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Medaka
Match: gba2 (glucosylceramidase beta 2 [Source:NCBI gene;Acc:101175270])

HSP 1 Score: 624.78 bits (1610), Expect = 0.000e+0
Identity = 356/830 (42.89%), Postives = 485/830 (58.43%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDL---SGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLK--SCGVPDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALD 2570
            VP+ GW + L      K KP+       S ++  +   IRYL + Y++ + E K PFID  + +  + IYG P+GGIG G I RG+RGEFCR+ L PG+Y YKT  A+QF V +RR G TVYQQVLSV    E   +L  WNW +    A Y  L+PRAWTVY +  Q + L CRQISPVIPH+YKDS LP+ VF W+  N     L +SI   + NG+G  D++S G      NE F    EG ++   +     +     +               T    +    G   LW +LM++G L   SG      K  K       G  V  P    +++ F   W MPL+ F     ++ RRY R+F        +  +  YA+ + + WE +IE WQ PIL++S  PSWYKSALFNELYFV DGGTVW +   +  VS  + + D    A+     +YG F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY+IA S    D +  L++  G      +   +PHD+GDP++EP+ ++NAY +++T  WKDLN KFVLQV+RD+ + ++  YLK M PI   VM+  + +D DGDGLIENSGYADQTYD W   G SAY GGLWL +L  +C M++ ++ + ++  + D L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+LK  +CG  D + F ++K+++TL++IF  N ++  G + GA+NG  P    D SSVQS+E W+GV Y LAATM  E    E     EG Y+TV+E  G+ FQTPE+Y +   +RSL YMRPL+IWA+Q AL+
Sbjct:   13 VPKEGWRICLAHVFKEKRKPFQAKDVSLSNLWEHIGLGIRYLRWWYKKTQVEKKAPFIDMFHALPLRQIYGAPLGGIGGGTITRGWRGEFCRWQLNPGMYHYKTVIADQFTVCLRRGGQTVYQQVLSV----EHPSTLQGWNWGYCGEYAFYHALYPRAWTVYHLPGQNVTLTCRQISPVIPHDYKDSSLPVAVFVWDIENKNDYALEVSIMFTMVNGSGHKDDSSGG----HWNEPFHLEKEGKALSGVLLHHCTAVNPYTLCISAREQPDRKVSHQTAFSPSGTCSG---LWSDLMTDGRLDSPSGSSPPTQKGEKVAAALAVGCSV--PAHGHNDVEFCLAWDMPLITFGSRERKHVRRYTRYFGSKGE--ASPSLSHYALTHYKEWERRIEEWQSPILQDSSLPSWYKSALFNELYFVADGGTVWTELAEDADVSGGVRSEDGGLPAQPDVIKEYGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSVQYDIAGSVVQQDLTERLHLMSGRYSPVKTKNVVPHDIGDPDDEPWHRLNAYLIHDTAGWKDLNLKFVLQVYRDFHITQDNQYLKDMWPICQAVMESEIKFDLDGDGLIENSGYADQTYDGWTVTGPSAYCGGLWLASLCVMCKMARLVDTERTYQHYKDILDRGSAAFDKLLWNGKYYNYDSSGRYHSNSVMSDQCAGHWFLKASACGEEDYQAFPKEKIQSTLKSIFDLNVMAFAGGQMGAVNGMRPEGVPDRSSVQSDEVWIGVVYGLAATMIHEGMREEGMHTAEGCYRTVWERLGMAFQTPEAYCEKNIYRSLAYMRPLSIWAMQLALN 827

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Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDL---SGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLK--SCGVPDNEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALD 2570
            VP+ GW + L      K KP+       S ++  +   IRYL + Y++ + E K PFID  + +  + IYG P+GGIG G I RG+RGEFCR+ L PG+Y YKT  A+QF V +RR G TVYQQVLSV    E   +L  WNW +    A Y  L+PRAWTVY +  Q + L CRQISPVIPH+YKDS LP+ VF W+  N     L +SI   + NG+G  D++S G      NE F    EG ++   +     +     +               T    +    G   LW +LM++G L   SG      K  K       G  V  P    +++ F   W MPL+ F     ++ RRY R+F        +  +  YA+ + + WE +IE WQ PIL++S  PSWYKSALFNELYFV DGGTVW +   +  VS  + + D    A+     +YG F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY+IA S    D +  L++  G      +   +PHD+GDP++EP+ ++NAY +++T  WKDLN KFVLQV+RD+ + ++  YLK M PI   VM+  + +D DGDGLIENSGYADQTYD W   G SAY GGLWL +L  +C M++ ++ + ++  + D L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+LK  +CG  D + F ++K+++TL++IF  N ++  G + GA+NG  P    D SSVQS+E W+GV Y LAATM  E    E     EG Y+TV+E  G+ FQTPE+Y +   +RSL YMRPL+IWA+Q AL+
Sbjct:   26 VPKEGWRICLAHVFKEKRKPFQAKDVSLSNLWEHIGLGIRYLRWWYKKTQVEKKAPFIDMFHALPLRQIYGAPLGGIGGGTITRGWRGEFCRWQLNPGMYHYKTVIADQFTVCLRRGGQTVYQQVLSV----EHPSTLQGWNWGYCGEYAFYHALYPRAWTVYHLPGQNVTLTCRQISPVIPHDYKDSSLPVAVFVWDIENKNDYALEVSIMFTMVNGSGHKDDSSGG----HWNEPFHLEKEGKALSGVLLHHCTAVNPYTLCISAREQPDRKVSHQTAFSPSGTCSG---LWSDLMTDGRLDSPSGSSPPTQKGEKVAAALAVGCSV--PAHGHNDVEFCLAWDMPLITFGSRERKHVRRYTRYFGSKGE--ASPSLSHYALTHYKEWERRIEEWQSPILQDSSLPSWYKSALFNELYFVADGGTVWTELAEDADVSGGVRSEDGGLPAQPDVIKEYGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSVQYDIAGSVVQQDLTERLHLMSGRYSPVKTKNVVPHDIGDPDDEPWHRLNAYLIHDTAGWKDLNLKFVLQVYRDFHITQDNQYLKDMWPICQAVMESEIKFDLDGDGLIENSGYADQTYDGWTVTGPSAYCGGLWLASLCVMCKMARLVDTERTYQHYKDILDRGSAAFDKLLWNGKYYNYDSSGRYHSNSVMSDQCAGHWFLKASACGEEDYQAFPKEKIQSTLKSIFDLNVMAFAGGQMGAVNGMRPEGVPDRSSVQSDEVWIGVVYGLAATMIHEGMREEGMHTAEGCYRTVWERLGMAFQTPEAYCEKNIYRSLAYMRPLSIWAMQLALN 840

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BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Medaka
Match: gba2 (glucosylceramidase beta 2 [Source:NCBI gene;Acc:101175270])

HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0
Identity = 356/833 (42.74%), Postives = 483/833 (57.98%), Query Frame = 3

Query:  141 VPQYGWNVVLDWNPPVKCKPYTLP--RFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFF---EGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDL---SGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLD---NVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSF--FADALSKGKKAYVDKLWTGSYFKYDE----RSCSVMADQLCGHWYLK--SCGVPD---NEVFDQDKVRTTLRTIFQNNCVSL-GTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALD 2570
            VP+ GW + L      K KP+       S ++  +   IRYL + Y++ + E K PFID  + +  + IYG P+GGIG G I RG+RGEFCR+ L PG+Y YKT  A+QF V +RR G TVYQQVLSV    E   +L  WNW +    A Y  L+PRAWTVY +  Q + L CRQISPVIPH+YKDS LP+ VF W+  N     L +SI   + NG+G  D++S G      NE F    EG ++   +     +     +               T    +    G   LW +LM++G L   SG      K  K       G  V  P    +++ F   W MPL+ F     ++ RRY R+F        +  +  YA+ + + WE +IE WQ PIL++S  PSWYKSALFNELYFV DGGTVW +   +  VS  + + D    A+     +YG F YLEG EYRMYNTYDVH Y+S++L+ LWPKL  S+QY+IA S    D +  L++  G      +   +PHD+GDP++EP+ ++NAY +++T  WKDLN KFVLQV+RD+ + ++  YLK M PI   VM+  + +D DGDGLIENSGYADQTYD W   G SAY GGLWL +L  +C M++ ++ + ++  + D L +G  A+   LW G Y+ YD      S SVM+DQ  GHW+LK  +CG  D   N    + K+++TL++IF  N ++  G + GA+NG  P    D SSVQS+E W+GV Y LAATM  E    E     EG Y+TV+E  G+ FQTPE+Y +   +RSL YMRPL+IWA+Q AL+
Sbjct:   26 VPKEGWRICLAHVFKEKRKPFQAKDVSLSNLWEHIGLGIRYLRWWYKKTQVEKKAPFIDMFHALPLRQIYGAPLGGIGGGTITRGWRGEFCRWQLNPGMYHYKTVIADQFTVCLRRGGQTVYQQVLSV----EHPSTLQGWNWGYCGEYAFYHALYPRAWTVYHLPGQNVTLTCRQISPVIPHDYKDSSLPVAVFVWDIENKNDYALEVSIMFTMVNGSGHKDDSSGG----HWNEPFHLEKEGKALSGVLLHHCTAVNPYTLCISAREQPDRKVSHQTAFSPSGTCSG---LWSDLMTDGRLDSPSGSSPPTQKGEKVAAALAVGCSV--PAHGHNDVEFCLAWDMPLITFGSRERKHVRRYTRYFGSKGE--ASPSLSHYALTHYKEWERRIEEWQSPILQDSSLPSWYKSALFNELYFVADGGTVWTELAEDADVSGGVRSEDGGLPAQPDVIKEYGRFAYLEGQEYRMYNTYDVHFYASFALIMLWPKLALSVQYDIAGSVVQQDLTERLHLMSGRYSPVKTKNVVPHDIGDPDDEPWHRLNAYLIHDTAGWKDLNLKFVLQVYRDFHITQDNQYLKDMWPICQAVMESEIKFDLDGDGLIENSGYADQTYDGWTVTGPSAYCGGLWLASLCVMCKMARLVDTERTYQHYKDILDRGSAAFDKLLWNGKYYNYDSSGRYHSNSVMSDQCAGHWFLKASACGEEDYQANVFKSKQKIQSTLKSIFDLNVMAFAGGQMGAVNGMRPEGVPDRSSVQSDEVWIGVVYGLAATMIHEGMREEGMHTAEGCYRTVWERLGMAFQTPEAYCEKNIYRSLAYMRPLSIWAMQLALN 843

[Close]

BLAST of Non-lysosomal glucosylceramidase vs. Planmine SMEST
Match: SMESG000080285.1 (SMESG000080285.1)

HSP 1 Score: 1697.18 bits (4394), Expect = 0.000e+0
Identity = 826/830 (99.52%), Postives = 829/830 (99.88%), Query Frame = 3

Query:   87 MDPKVVKLFDTRNIDEVKVPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLNEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVXXXXXXXXXXXXXXXNANIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSFFADALSKGKKAYVDKLWTGSYFKYDERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDQR 2576
            MDPKVVKLFDTRNIDEVKVPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL+EEFFEGCSIRQ+IKDMDCSYGLGVMKTVNVSTSSCSSISLTNTRSN NIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSFFADALSKGKKAYVDKLWTGSYFKYDERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALD+R
Sbjct:    1 MDPKVVKLFDTRNIDEVKVPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGFVSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINRGYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPEDLQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHEYKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSLDEEFFEGCSIRQQIKDMDCSYGLGVMKTVNVSTSSCSSISLTNTRSNGNIPGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIRFVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESWEEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLENGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKLQESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFVKINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKKCLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSKHLNIDCSFFADALSKGKKAYVDKLWTGSYFKYDERSCSVMADQLCGHWYLKSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGTKFGAINGCLPNKTKDTSSVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTPESYFDTGHFRSLGYMRPLAIWAIQYALDKR 830

The following BLAST results are available for this feature:

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Human
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Celegans
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Fly
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Zebrafish
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Xenopus
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Mouse
BLAST of Non-lysosomal glucosylceramidase vs. UniProt/SwissProt
BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Cavefish
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Sea Lamprey
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Yeast
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Nematostella
BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Medaka
BLAST of Non-lysosomal glucosylceramidase vs. Planmine SMEST

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3


Match Name	E-value	Identity	Description
GBA2	0.000e+0	42.68	glucosylceramidase beta 2 [Source:HGNC Symbol;Acc:...	[more]
GBA2	0.000e+0	42.02	glucosylceramidase beta 2 [Source:HGNC Symbol;Acc:...	[more]
GBA2	7.904e-20	48.54	glucosylceramidase beta 2 [Source:HGNC Symbol;Acc:...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hpo-13	0.000e+0	37.92	Non-lysosomal glucosylceramidase [Source:UniProtK...	[more]
hpo-13	0.000e+0	37.92	Non-lysosomal glucosylceramidase [Source:UniProtK...	[more]
hpo-13	0.000e+0	37.92	Non-lysosomal glucosylceramidase [Source:UniProtK...	[more]
hpo-13	0.000e+0	37.92	Non-lysosomal glucosylceramidase [Source:UniProtK...	[more]
R08F11.1	2.238e-176	37.23	Non-lysosomal glucosylceramidase [Source:UniProtK...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
CG33090	1.028e-128	33.59	gene:FBgn0028916 transcript:FBtr0343675	[more]
CG33090	1.409e-126	33.01	gene:FBgn0028916 transcript:FBtr0343674	[more]
CG33090	4.235e-126	32.94	gene:FBgn0028916 transcript:FBtr0080624	[more]
CG33090	7.227e-113	32.77	gene:FBgn0028916 transcript:FBtr0343673	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
gba2	0.000e+0	43.51	glucosidase, beta (bile acid) 2 [Source:ZFIN;Acc:Z...	[more]
gba2	0.000e+0	43.51	glucosidase, beta (bile acid) 2 [Source:ZFIN;Acc:Z...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Gba2	0.000e+0	42.18	glucosidase beta 2 [Source:MGI Symbol;Acc:MGI:2654...	[more]
Gba2	4.162e-13	40.00	glucosidase beta 2 [Source:MGI Symbol;Acc:MGI:2654...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4


Match Name	E-value	Identity	Description
sp\|Q9HCG7\|GBA2_HUMAN	0.000e+0	42.68	Non-lysosomal glucosylceramidase OS=Homo sapiens O...	[more]
sp\|Q5M868\|GBA2_RAT	0.000e+0	42.46	Non-lysosomal glucosylceramidase OS=Rattus norvegi...	[more]
sp\|Q69ZF3\|GBA2_MOUSE	0.000e+0	42.18	Non-lysosomal glucosylceramidase OS=Mus musculus O...	[more]
sp\|Q7KT91\|C3390_DROME	4.245e-125	32.94	Non-lysosomal glucosylceramidase OS=Drosophila mel...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
T1JDY2	0.000e+0	46.78	Non-lysosomal glucosylceramidase OS=Strigamia mari...	[more]
A0A1S3HY00	0.000e+0	44.75	Non-lysosomal glucosylceramidase OS=Lingula unguis...	[more]
K1R968	0.000e+0	44.98	Non-lysosomal glucosylceramidase OS=Crassostrea gi...	[more]
A0A0L8HXG2	0.000e+0	45.66	Non-lysosomal glucosylceramidase OS=Octopus bimacu...	[more]
V4B001	0.000e+0	45.50	Non-lysosomal glucosylceramidase OS=Lottia gigante...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
gba2	0.000e+0	42.31	glucosylceramidase beta 2 [Source:NCBI gene;Acc:10...	[more]
gba2	0.000e+0	42.07	glucosylceramidase beta 2 [Source:NCBI gene;Acc:10...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
gba2	0.000e+0	43.16	glucosidase, beta (bile acid) 2 [Source:ZFIN;Acc:Z...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO31657	0.000e+0	42.19	Non-lysosomal glucosylceramidase [Source:UniProtK...	[more]
EDO27312	1.542e-27	50.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
gba2	0.000e+0	42.89	glucosylceramidase beta 2 [Source:NCBI gene;Acc:10...	[more]
gba2	0.000e+0	42.89	glucosylceramidase beta 2 [Source:NCBI gene;Acc:10...	[more]
gba2	0.000e+0	42.74	glucosylceramidase beta 2 [Source:NCBI gene;Acc:10...	[more]

BLAST of Non-lysosomal glucosylceramidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000080285.1	0.000e+0	99.52	SMESG000080285.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033866 ID=SMED30033866|Name=Non-lysosomal glucosylceramidase|organism=Schmidtea mediterranea sexual|type=transcript|length=2801bp
ACATTAGTTTTAAAAAATTACAGATTATAATATTATGGATAATTTTTGAA
ATTTAAATTATTGAATAAACAATTTTTATTATCTATATGGATCCAAAAGT
TGTAAAGTTATTTGATACACGAAACATCGACGAGGTTAAAGTGCCTCAAT
ATGGTTGGAATGTAGTCTTAGATTGGAATCCACCCGTAAAATGTAAACCG
TATACATTACCAAGATTTAGTCAAATTTATGGATTTGTTTCTTCGGCAAT
CAGATATTTGTTCTATGTTTATCGTCGGAAAAAGAAAGAGGATAAAAAAC
CATTTATTGACTGTATTAATCCAGTAAGCTGGCAACCAATTTATGGTGTA
CCAATGGGTGGCATTGGAAGTGGAGCTATTAATAGAGGGTATCGAGGTGA
ATTTTGTAGATTTAGTTTAATTCCAGGGATTTACGAATATAAAACCGCGA
ACGCTAATCAGTTTATTGTTACAGTTCGTCGGAGAGGTATAACGGTTTAT
CAACAAGTATTATCTGTACATAAAGCACCAGAAGATTTGCAGTCTCTTAA
TTGCTGGAATTGGCAATTTCCTAGTTCTAGGGCAGCATATGTCGGTCTAT
TCCCTAGAGCTTGGACAGTTTATGATATAGTTGAACAAAAAATAAAATTA
TACTGTCGACAAATATCTCCAGTAATTCCTCATGAATACAAGGATTCTTG
TTTGCCGTTATGCGTTTTCGAGTGGAACGCAGTCAACTACGGCAAAGAGG
AATTAACAATCAGTATTTGTTGCGTTATTAAAAACGGAACTGGACTGCTA
GATAACGCATCTCAGGGATTAATATCAAGTTCTCTAAACGAGGAGTTCTT
TGAAGGCTGTTCTATTAGACAAAAGATCAAAGATATGGATTGTAGTTACG
GTCTAGGTGTTATGAAAACTGTCAATGTCTCCACATCAAGTTGTTCATCG
ATATCATTAACAAATACCCGGTCCAATGCCAATATACCGGGCCCCAAAGA
ACTGTGGGAAAATCTAATGAGTAACGGGGATCTGTCGGGAATGAAATCCA
AAGAAATGAAGCATAACAAAGATATATTAATTGCAACATGTGGTAAAGTT
GTTGTGAAACCCATGAGCAAATCACACGAAATACGATTTGTGTTTGTTTG
GCATATGCCTCTCGTTCATTTCAGAGACAACACAGTCCAATATAGAAGGA
GATACGCTCGATGGTTCCATTGTGACGATCTCAAGTTGGGTACAAGTCAA
ATGATTGAATATGCAATGAGAAATGTGGAATCTTGGGAAGAAAAAATAGA
AAATTGGCAAAAACCAATATTAGAAAATAGCAAATATCCCAGTTGGTACA
AATCCGCGCTGTTCAATGAACTTTATTTTGTTGTTGATGGAGGAACGGTT
TGGCTGGATAATGTTTCTGTCTCTGTTTCCCTTGAGAATGGCGACAGCAT
CGCAATCGCGAGAAATAAACACCAAATTGATTACGGAACATTTGGTTACC
TGGAAGGACACGAATACAGAATGTATAATACTTATGATGTGCATCACTAT
TCAAGCTGGTCGTTGGTAGCTCTTTGGCCTAAGTTACAAGAATCAATTCA
GTATAATATTGCCGATTCAACTAAGTCAGTTGATTCTTCGCTAATCTTAT
ATATACACAAAGGGACGCTTGAGACAAGAAGCAGTCTCTTTGCAATTCCT
CACGATGTTGGGGATCCAGAAGAAGAACCGTTTGTGAAAATCAATGCATA
CACTATGTATAATACTGATCAGTGGAAAGACCTCAATCCCAAATTTGTTC
TCCAAGTCTTTCGTGATTGGATTGTGTTGAAAAATGAAGATTACTTGAAA
TATATGATGCCTATAGTATTGGAAGTAATGAAGAAATGTCTTTCATGGGA
TAAAGATGGCGATGGGCTTATTGAGAATTCTGGGTATGCTGATCAAACCT
ATGATGCTTGGATTGCGAAGGGTGCCAGTGCATATACTGGTGGACTTTGG
TTAGGTGCTTTATATTCTGTCTGCCACATGTCGAAGCACTTGAATATTGA
TTGTTCATTTTTTGCAGATGCCCTTTCTAAGGGTAAAAAAGCATATGTTG
ATAAATTATGGACAGGTTCATATTTTAAATATGATGAACGTAGCTGCTCT
GTGATGGCTGATCAACTTTGTGGACATTGGTATTTAAAAAGCTGTGGTGT
ACCTGACAATGAAGTGTTTGATCAAGATAAAGTTCGAACGACTTTACGAA
CGATTTTTCAAAACAATTGTGTTTCCCTTGGCACAAAGTTTGGGGCGATA
AATGGCTGTTTGCCAAATAAAACCAAAGATACAAGCAGCGTCCAATCTGA
AGAATTCTGGGTTGGAGTGAATTATGCATTGGCTGCTACAATGTTTCTAG
AACACTGTGACAATGAAGCTTGGACTATTGTCGAAGGCACCTATAAAACT
GTATATGAAAATTATGGGTTACAATTTCAGACACCTGAATCTTATTTTGA
TACCGGACATTTTCGTTCTTTGGGCTACATGAGACCTCTAGCTATTTGGG
CAATCCAGTATGCGCTGGATCAACGCTAAAATCCATCGCGATAGTTTTAT
AAGAAAAAATTATTAATTATATTGTCAATTAGCTCTTGAATTTGATGGCA
AATGTACAAATGTCGGATATTTATAATTCTAAATGCTACACCGTGACTTC
CTGCTAATATATTTGAAGATTTTAAGTATTAGCATTATATCGAATTATAT
TAACATTATTTTTTTTTTATTAATATATTTTTTATTATTGTTTAAAAAAA
A

protein sequence of SMED30033866-orf-1

>SMED30033866-orf-1 ID=SMED30033866-orf-1|Name=SMED30033866-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=831bp
MDPKVVKLFDTRNIDEVKVPQYGWNVVLDWNPPVKCKPYTLPRFSQIYGF
VSSAIRYLFYVYRRKKKEDKKPFIDCINPVSWQPIYGVPMGGIGSGAINR
GYRGEFCRFSLIPGIYEYKTANANQFIVTVRRRGITVYQQVLSVHKAPED
LQSLNCWNWQFPSSRAAYVGLFPRAWTVYDIVEQKIKLYCRQISPVIPHE
YKDSCLPLCVFEWNAVNYGKEELTISICCVIKNGTGLLDNASQGLISSSL
NEEFFEGCSIRQKIKDMDCSYGLGVMKTVNVSTSSCSSISLTNTRSNANI
PGPKELWENLMSNGDLSGMKSKEMKHNKDILIATCGKVVVKPMSKSHEIR
FVFVWHMPLVHFRDNTVQYRRRYARWFHCDDLKLGTSQMIEYAMRNVESW
EEKIENWQKPILENSKYPSWYKSALFNELYFVVDGGTVWLDNVSVSVSLE
NGDSIAIARNKHQIDYGTFGYLEGHEYRMYNTYDVHHYSSWSLVALWPKL
QESIQYNIADSTKSVDSSLILYIHKGTLETRSSLFAIPHDVGDPEEEPFV
KINAYTMYNTDQWKDLNPKFVLQVFRDWIVLKNEDYLKYMMPIVLEVMKK
CLSWDKDGDGLIENSGYADQTYDAWIAKGASAYTGGLWLGALYSVCHMSK
HLNIDCSFFADALSKGKKAYVDKLWTGSYFKYDERSCSVMADQLCGHWYL
KSCGVPDNEVFDQDKVRTTLRTIFQNNCVSLGTKFGAINGCLPNKTKDTS
SVQSEEFWVGVNYALAATMFLEHCDNEAWTIVEGTYKTVYENYGLQFQTP
ESYFDTGHFRSLGYMRPLAIWAIQYALDQR*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx

Vocabulary: **INTERPRO**
Term	Definition
IPR012341	6hp_glycosidase-like_sf
IPR024462	GH116_N
IPR006775	GH116_catalytic
IPR008928	6-hairpin_glycosidase_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0003824	catalytic activity
GO:0004348	glucosylceramidase activity
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Vocabulary: **biological process**
Term	Definition
GO:0006629	lipid metabolic process
GO:0006680	glucosylceramide catabolic process
GO:0008152	metabolic process

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR006775	Glycosyl-hydrolase family 116, catalytic region	PFAM	PF04685	DUF608	coord: 467..823 e-value: 3.1E-142 score: 474.0
IPR024462	Glycosyl-hydrolase family 116, N-terminal	PFAM	PF12215	Glyco_hydr_116N	coord: 87..400 e-value: 2.1E-83 score: 280.4
IPR012341	Six-hairpin glycosidase-like superfamily	GENE3D	G3DSA:1.50.10.10		coord: 490..727 e-value: 8.4E-6 score: 27.6
None	No IPR available	PANTHER	PTHR12654	BILE ACID BETA-GLUCOSIDASE-RELATED	coord: 13..829
None	No IPR available	PANTHER	PTHR12654:SF0	NON-LYSOSOMAL GLUCOSYLCERAMIDASE	coord: 13..829
IPR008928	Six-hairpin glycosidase superfamily	SUPERFAMILY	SSF48208	Six-hairpin glycosidases	coord: 396..822

Main menu

Non-lysosomal glucosylceramidase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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