Protein kinase domain-containing protein

Overview
NameProtein kinase domain-containing protein
Smed IDSMED30033865
Length (bp)2388
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein kinase domain-containing protein (SMED30033865) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30033865) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30033865) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30033865) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30033865

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30033865SMESG000001493.1 SmedASXL_013994SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30033865SMESG000001493.1 SmedASXL_013994SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: HASPIN (histone H3 associated protein kinase [Source:HGNC Symbol;Acc:HGNC:19682])

HSP 1 Score: 239.965 bits (611), Expect = 2.713e-67
Identity = 133/353 (37.68%), Postives = 210/353 (59.49%), Query Frame = 1 
Query:  913 DSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN---VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNY--KFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRING-TNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPR--GDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            ++LS S  +A   +K+   C Q     +         +   K+GEGV+GEVF+    +    +K+  + G  LVNG  Q TFE++ PE+ +SK+L+ L+G+    RT  F+ L     V+G  P +L+  W  + S +G+ N+  DF  D Q ++ LE+EF G  L     K +     +SI+ Q+T SLAVAEA+++FEHRDLHW N+L+K T   KL Y +NG ++ I +C GL V++ID+T+SR+  D   V+ D+S   ++F G+GDYQF+IYR+MK +N N W E++P SN+ W+HYL DK+L + ++      P  K I+ ++ + +  +L F SA +L+ +   F+
Sbjct:  448 NTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGE-VCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSC-GLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 798
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: hasp-1 (HASPin kinase related [Source:UniProtKB/TrEMBL;Acc:G5EE25])

HSP 1 Score: 192.971 bits (489), Expect = 6.035e-51
Identity = 112/352 (31.82%), Postives = 190/352 (53.98%), Query Frame = 1 
Query:  925 ASLVQADPEQKILDLCDQSQIRSWCSFFDD-VSNKTTNKVGEGVYGEVFK-LYRGN--VLKVFPVNGDLL-------VNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTD-KQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYF 1944
             S +   P  ++L +  Q + ++W S     +  +   K+GEG YGEVF  ++ G    +K+ P   D          + E+  T + V PEV V K+L+ L  ++    T NF+++  A +V GK P+ L+  W  +   + ++N   D  +   Q ++       G  L ++     +E+ SII Q+ +S+  AEAA++FEHRDLH  N+L+      +L Y ++G     +  G+ V +IDFT+SR+   + TVY D+ + P IFEG+ D QFE+YR M+ + ++NW++F+ R+NL WI Y+ ++L+     P+G    K   +EL  L++R  +F S  E +  +E+F
Sbjct:  584 TSEIDPSPMMQLLHVVGQKESKTWDSLPKSALDGRRVKKLGEGAYGEVFSTIWDGKPVAIKIVPFEKDGCNRQYFGEYHSEEMQTSDVVLPEVIVMKELSALRDEDAWNSTPNFIEMISAEVVMGKYPKGLLSAWDSYDKLKESENTRPDVYSSIDQNFILFVSANGGIALEDFVLESENELFSIIHQLVLSMNAAEAALEFEHRDLHLGNVLIDRNGVKELYYTVHGQKVPLSTHGIKVNIIDFTLSRISKGATTVYWDLENDPAIFEGQDDPQFEVYREMRKNCKSNWKKFSRRTNLMWIVYIANRLIDTKICPKGLLTEKR-RMELKVLFDRFAEFGSCGESLTNEEFF 934
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: hasp-2 (HASPin kinase related [Source:UniProtKB/TrEMBL;Acc:Q9BL96])

HSP 1 Score: 176.407 bits (446), Expect = 6.897e-48
Identity = 110/345 (31.88%), Postives = 180/345 (52.17%), Query Frame = 1 
Query:  943 DPEQ-KILDLCDQSQIRSWCSF-FDDVSNKTTNKVGEGVYGEVFKLY---RGNVLKVFPVNGDLLVNGEDQM---TFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLD---FLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYF 1944
            DP   ++L +  Q + + W S     +  +   K+GEG YGEVF      R   +KV P   +    G   +   T   V  EV V K+L+ L   N    T NF+++  A +V G+ P+ L+  W  +  D+  ++E L    + ++ Q ++       G  L+++      E+ SII Q+ +S+  AEAA++FEHRDL+  N+L+      +L Y ++G        G+ V +IDFT+SR+  DS T+Y D+ +   IFEG    QFE+YR M+ + R NW +F+ R+NL WI Y+ ++L+     P G    K  + EL  L++R+ +F S +E +   E++
Sbjct:   77 DPSMAQLLRVVGQKEAKPWGSLPTSALDARKVKKLGEGAYGEVFSTVWNGRPVAIKVLPFENNGCFYGNQSVEIPTTHAVLSEVIVMKELSALRDPNSWNSTPNFIEMISAQIVMGEYPKGLLRAWDAY--DKLNESEHLRPDVYSSEHQNFILFVSANGGISLADFVLESEDELFSIIHQLVLSMVAAEAALEFEHRDLNLSNVLIDRNGVEELSYTVHGQKIPLRTHGIKVNIIDFTLSRISKDSTTIYWDLEEDTTIFEGPDAPQFEVYREMRENCRGNWEKFSRRTNLMWIVYIANRLIDTEICPEGLFTDKRRK-ELKHLFDRLAEFGSCEESLTDAEFY 418
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: H12I13.1 (pep chromosome:WBcel235:II:6061977:6067166:-1 gene:WBGene00019190.1 transcript:H12I13.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:H12I13.1)

HSP 1 Score: 63.5438 bits (153), Expect = 5.543e-10
Identity = 70/290 (24.14%), Postives = 125/290 (43.10%), Query Frame = 1 
Query:  832 SKPWKQMRKIESSQECNDSSSCTSVGEDSLSASLVQADPEQ--------KILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSD 1677
            + P    RK+       D+ S   V   SLS    +   E+        KIL + +   + SW    ++   +   K+G G YG  + +  G    V  + G   +   +Q+    +F E+ ++++L +L  KN++    NF++    S V   +P   +   +  K+ R                +A+     G  L N+KF  Y +  S+  Q+ +SL V + ++   HRD+H  N+LV  TK   L Y ++G   + N +G+ + +IDF+ S     +     DM+D
Sbjct:  610 AHPMSSRRKM-----IRDNKSSNKVCRTSLSGGAKKKRKERNARSEVGDKILGITETKTVTSW----NESGIELQRKIGFGAYGSAYSVKYGGKTVVMKLIG---IRDNEQL----LFNELIITQQLGKL-AKNRV--CPNFLEYC-GSHVMTDVP---VGMRRDPKAIR---------------HLAILMARGGGVLDNWKFKDYRQCVSVFCQLVMSLKVVKDSINMVHRDIHLWNVLVSRTKTTCLDYSMDGKVKL-NSYGVVMHLIDFSKSLYGGQNKKTNEDMND 860
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: C06E4.5 (pep chromosome:WBcel235:IV:7254990:7255909:1 gene:WBGene00015534.1 transcript:C06E4.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C06E4.5)

HSP 1 Score: 58.5362 bits (140), Expect = 1.348e-9
Identity = 33/100 (33.00%), Postives = 52/100 (52.00%), Query Frame = 1 
Query: 1339 DFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSI--IEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVS 1632
            +F   +  ++ +  E  G PLS    N  H  +SI  ++Q+   L VA +  +F H+DLH  N+L+  TK + L+Y I   N   N  G+ V V D++ S
Sbjct:   27 EFTATRSAFLMILMELGGSPLSAKPDNSLHAHQSIRIMKQVIFWLFVANSKFKFAHQDLHCGNVLIGKTKDVLLQYSIGQKNISINSKGILVKVCDYSES 126
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: C26E6.1 (pep chromosome:WBcel235:III:4956891:4957539:1 gene:WBGene00016137.1 transcript:C26E6.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C26E6.1)

HSP 1 Score: 56.9954 bits (136), Expect = 5.987e-9
Identity = 31/94 (32.98%), Postives = 49/94 (52.13%), Query Frame = 1 
Query: 1345 LTDKQKWMALEYEFAGEPLSN-YKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDF 1623
            L+  +   A+  E  G  L+   KF    +V+S+I QI   L  A     + H D H  NIL+  T++  + Y++ GT Y+    G++VTVID+
Sbjct:   62 LSPHKTHFAMFMEMCGSELTGRIKFKSDEQVKSVICQIIFFLVAARKKSGYSHNDFHKRNILINDTRKETICYKVEGTEYVLKTSGVWVTVIDY 155
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Haspin (gene:FBgn0046706 transcript:FBtr0113784)

HSP 1 Score: 221.861 bits (564), Expect = 6.393e-63
Identity = 120/366 (32.79%), Postives = 204/366 (55.74%), Query Frame = 1 
Query:  853 RKIES-SQECNDSSSCTSVGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN----------VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELE-LNQLYNRILKFKSA 1914
            +K+E  S  C D  S    GE        +   E+ +L  C Q     + + ++      T K+GEG YGEVF+  R            VLK+ P+ G  ++NGE Q TF  + PE+ ++KK+  L   +K   T+ FV ++K S+V+G+ P   I  W+++ +++G++N+  +   D Q +  LE +FAG  ++N+KF    +    ++QI ++LAV E   QFEHRDLH  NIL++ T +  +      +N      G+ VT+ID+T+SR+ ++    + D+S   E+F+  GDYQ+++YRMM+N+ +NNW  F+P++N+ W+ Y+I K+L    Y   +     + ++ + +L N I+ F+SA
Sbjct:  196 KKVERRSSICQDRKSLVLKGEHKF-----ENKYEEDVLKYCHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIITKKMCSLR-TSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQATGDYQYDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIKELKNIIMTFESA 555
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: si:dkeyp-26a9.2 (si:dkeyp-26a9.2 [Source:ZFIN;Acc:ZDB-GENE-090313-379])

HSP 1 Score: 254.218 bits (648), Expect = 4.160e-71
Identity = 134/340 (39.41%), Postives = 199/340 (58.53%), Query Frame = 1 
Query:  952 QKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN----VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNY--KFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDS--KSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            +K+   C QS   S+         K  NK+GEG +GEVF     +     LK+ PV G   VNGE Q TF ++  E+ +SK+L+ LN K +  ++  F+ L     VRG  P+ L+  W +F   +G++N+  DF  D+Q ++ LE+EF G  L N   K +   + +S++ Q+T SLAVAE A+ FEHRDLHW NILVK  K     + +NGT +     G+ V +ID+++SR+ +D  TV  D+S   E+F G+GDYQFEIYR+MK +N+N W  +NP SN+ W+HYL DKLL   +Y      S  ++++  LN   + I+ + SA E + K  +F+
Sbjct:  755 EKVYQECQQSGPLSFSDCIPPARMKHLNKIGEGTFGEVFSTINDSNESVALKIIPVEGSQQVNGEHQKTFGEILHEIIISKELSSLNLK-EFNKSDGFIGLNNLHCVRGCYPEALLKAWDKFDHQKGSENDRPDFFDDEQLFLILEFEFGGSDLENMNGKLSSMAQAKSVLHQVTASLAVAEQALCFEHRDLHWGNILVKNVKHKHNEFILNGTVHCIETRGVHVNIIDYSLSRLEIDGLTVSCDISSDEELFMGQGDYQFEIYRLMKKENKNCWSAYNPHSNVLWLHYLADKLL-SMNYRNKTQSSQQRTLKSALNAFKSEIMNYPSATEALMKCSFFQ 1092
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Haspin (histone H3 associated protein kinase [Source:MGI Symbol;Acc:MGI:1194498])

HSP 1 Score: 238.039 bits (606), Expect = 5.402e-67
Identity = 133/364 (36.54%), Postives = 203/364 (55.77%), Query Frame = 1 
Query:  886 SSSCTSVGEDSLSASLVQADPE----QKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNV---LKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYK--FNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDS--KSIELELNQLYNRILKFKSAQELIEKDEYF 1944
            SS C+SV   S   +L   D      +K+   C+Q     +         +   K+GEGV+GEVF++        LK+  + G  LVNG  Q TFE++ PE+ +SK+L+ L+ +    RT  F+ L     V+G  P +L+  W  + + + + N+  DF  + Q ++ LE+EF G  L   K   +     +SI+ QIT SLAVAEA++ FEHRDLHW N+L+K T   +LRY +NG        GL V +ID+T+SR+  D   V+ D+S   ++F GEGDYQFEIYR+M+ +N+N W E++P +N+ W+HYL DK+L++  +      +  K I   L   +  +L F SA +L+ +   F
Sbjct:  391 SSRCSSVYLLSPLKTLHVTDQRPSYAEKVYGECNQEGPIPFSDCLSTEKLERCEKIGEGVFGEVFQIINDQAPVALKIIAIEGLDLVNGSHQKTFEEILPEIIISKELSLLSSE-AYNRTEGFIGLNSVHCVQGLYPPLLLKAWDHYNTTKRSANDRPDFFQEDQLFIILEFEFGGVDLERMKTKLSSVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTNLKELRYTLNGKTSTIPTHGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQFEIYRLMRKENKNCWGEYHPYNNVLWLHYLTDKILNKMKFKTKCQSAAMKQIRKNLQHFHRTVLSFSSATDLLCQHSLF 753
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2KIP2|HASP_BOVIN (Serine/threonine-protein kinase haspin OS=Bos taurus OX=9913 GN=HASPIN PE=2 SV=1)

HSP 1 Score: 243.432 bits (620), Expect = 6.790e-68
Identity = 125/339 (36.87%), Postives = 197/339 (58.11%), Query Frame = 1 
Query:  952 QKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN---VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNY--KFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSY--PRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            +K+   C+Q     +  +  +   +   K+GEGV+GEVF+    +    LK+  + G  LVNG  Q TFE++ PE+ +SK+L+ L+      RT  F+ L     V+G  P +L+  W  + S +G+ N+  DF  + Q ++ LE+EF G  L     K +     +SI+ QIT SLAVAEA++ FEHRDLHW N+L+K T   +L Y +NG        GL V +ID+T+SR+  D   V+ D+S   ++F G+GDYQFEIYR+M+ +N N W E++P +N+ W+HYL DK+L++ ++      P  K ++ ++   Y  +L F SA +L+ +   F+
Sbjct:  444 EKLYGECNQVGPIPFSDYLSEEKLECCEKIGEGVFGEVFQTVTNHTPVALKIIAIEGQNLVNGAHQKTFEEILPEIIISKELSLLS-DEACNRTEGFIGLNSVHCVQGSYPPLLLQAWDHYHSTKGSANDRPDFFREDQLFIVLEFEFGGIDLEQMRKKLSSIATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTSLKELHYTLNGKKSSIPTRGLQVNIIDYTLSRLERDGIVVFCDISRDEDLFMGQGDYQFEIYRLMRKENNNCWGEYHPYNNVLWLHYLTDKILNQMTFKSKHNTPALKRMKKQIQHFYQTMLNFSSATDLLCQHSLFK 781
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8TF76|HASP_HUMAN (Serine/threonine-protein kinase haspin OS=Homo sapiens OX=9606 GN=HASPIN PE=1 SV=3)

HSP 1 Score: 239.965 bits (611), Expect = 1.303e-66
Identity = 133/353 (37.68%), Postives = 210/353 (59.49%), Query Frame = 1 
Query:  913 DSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN---VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNY--KFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRING-TNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPR--GDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            ++LS S  +A   +K+   C Q     +         +   K+GEGV+GEVF+    +    +K+  + G  LVNG  Q TFE++ PE+ +SK+L+ L+G+    RT  F+ L     V+G  P +L+  W  + S +G+ N+  DF  D Q ++ LE+EF G  L     K +     +SI+ Q+T SLAVAEA+++FEHRDLHW N+L+K T   KL Y +NG ++ I +C GL V++ID+T+SR+  D   V+ D+S   ++F G+GDYQF+IYR+MK +N N W E++P SN+ W+HYL DK+L + ++      P  K I+ ++ + +  +L F SA +L+ +   F+
Sbjct:  448 NTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGE-VCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSC-GLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 798
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9Z0R0|HASP_MOUSE (Serine/threonine-protein kinase haspin OS=Mus musculus OX=10090 GN=Haspin PE=1 SV=3)

HSP 1 Score: 238.039 bits (606), Expect = 3.741e-66
Identity = 133/364 (36.54%), Postives = 203/364 (55.77%), Query Frame = 1 
Query:  886 SSSCTSVGEDSLSASLVQADPE----QKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNV---LKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYK--FNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDS--KSIELELNQLYNRILKFKSAQELIEKDEYF 1944
            SS C+SV   S   +L   D      +K+   C+Q     +         +   K+GEGV+GEVF++        LK+  + G  LVNG  Q TFE++ PE+ +SK+L+ L+ +    RT  F+ L     V+G  P +L+  W  + + + + N+  DF  + Q ++ LE+EF G  L   K   +     +SI+ QIT SLAVAEA++ FEHRDLHW N+L+K T   +LRY +NG        GL V +ID+T+SR+  D   V+ D+S   ++F GEGDYQFEIYR+M+ +N+N W E++P +N+ W+HYL DK+L++  +      +  K I   L   +  +L F SA +L+ +   F
Sbjct:  391 SSRCSSVYLLSPLKTLHVTDQRPSYAEKVYGECNQEGPIPFSDCLSTEKLERCEKIGEGVFGEVFQIINDQAPVALKIIAIEGLDLVNGSHQKTFEEILPEIIISKELSLLSSE-AYNRTEGFIGLNSVHCVQGLYPPLLLKAWDHYNTTKRSANDRPDFFQEDQLFIILEFEFGGVDLERMKTKLSSVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTNLKELRYTLNGKTSTIPTHGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQFEIYRLMRKENKNCWGEYHPYNNVLWLHYLTDKILNKMKFKTKCQSAAMKQIRKNLQHFHRTVLSFSSATDLLCQHSLF 753
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P83103|HASP_DROME (Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster OX=7227 GN=Haspin PE=2 SV=1)

HSP 1 Score: 221.861 bits (564), Expect = 6.408e-62
Identity = 120/366 (32.79%), Postives = 204/366 (55.74%), Query Frame = 1 
Query:  853 RKIES-SQECNDSSSCTSVGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN----------VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELE-LNQLYNRILKFKSA 1914
            +K+E  S  C D  S    GE        +   E+ +L  C Q     + + ++      T K+GEG YGEVF+  R            VLK+ P+ G  ++NGE Q TF  + PE+ ++KK+  L   +K   T+ FV ++K S+V+G+ P   I  W+++ +++G++N+  +   D Q +  LE +FAG  ++N+KF    +    ++QI ++LAV E   QFEHRDLH  NIL++ T +  +      +N      G+ VT+ID+T+SR+ ++    + D+S   E+F+  GDYQ+++YRMM+N+ +NNW  F+P++N+ W+ Y+I K+L    Y   +     + ++ + +L N I+ F+SA
Sbjct:  196 KKVERRSSICQDRKSLVLKGEHKF-----ENKYEEDVLKYCHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIITKKMCSLR-TSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQATGDYQYDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIKELKNIIMTFESA 555
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O80528|HASP_ARATH (Serine/threonine-protein kinase haspin homolog OS=Arabidopsis thaliana OX=3702 GN=HASPIN PE=1 SV=1)

HSP 1 Score: 187.193 bits (474), Expect = 3.067e-49
Identity = 117/352 (33.24%), Postives = 191/352 (54.26%), Query Frame = 1 
Query:  916 SLSASLV--QADPEQKILDL---CDQSQIRSWCSFFDDVSN-KTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYR--TSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEG-EGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYF 1944
            SL++ L+    D +Q ILDL   C Q +  ++   F      ++  K+GEG YGE F+    +V K+ P++GD  VNGE Q   +++  EV +S  L +L       +     +++ +   + +G    ILI  W+++ +  G++N+  DF  +KQ ++    E  G+ L ++    + E RS++ Q T  LAVAEAA +FEHRDLHW NIL+       L + + G       FG+ +++IDFT+SR+      +++D++  P +F+G +GD Q E YR MK    + W     R+N+ W+ YL+D LL + S+ R    S   E EL  L  R+ K++SA+E +  D +F
Sbjct:  246 SLTSDLIPTHQDFDQPILDLLSACGQMRPSNFIEAFSKFCEPESIVKIGEGTYGEAFR-AGSSVCKIVPIDGDFRVNGEVQKRADELLEEVILSWTLNQLRECETTAQNLCPTYIKTQDIKLCQGPYDPILIKAWEEWDAKHGSENDHPDF-PEKQCYVMFVLEHGGKDLESFVLLNFDEARSLLVQATAGLAVAEAAFEFEHRDLHWGNILLSRNNSDTLPFILEGKQVCIKTFGVQISIIDFTLSRINTGEKILFLDLTSDPYLFKGPKGDKQSETYRKMKAVTEDYWEGSFARTNVLWLIYLVDILLTKKSFER----SSKHERELRSLKKRMEKYESAKEAV-SDPFF 590
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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A3P6I3F1 (Protein kinase domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS6586 PE=4 SV=1)

HSP 1 Score: 431.795 bits (1109), Expect = 9.317e-140
Identity = 207/374 (55.35%), Postives = 277/374 (74.06%), Query Frame = 1 
Query:  853 RKIE-SSQECNDSSSC-TSVGEDS--LSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRIL--KFKSAQELIEKDEYFEKCR 1956
            RKIE  ++E   SS    SVG D   L+ SLV  DP  K+L+LC Q+++R + SFFD  S +  +KVGEGVYGEVF+  + +V+K+FP++GD+ VNGE QM    V+PEVF+SKKLTEL  K +  R+ NF+QL+KA++V GK P  L   WK+++ + G+DNEC+DFL   Q+WM LE+++AG+PL   KF+ + E RS+IEQI ISLA AE+A+QFEHRDLHWLN+LVKPTKQ KLRYR++G  Y     G+ V +IDFTVSR+C + N VY+DMS+ PEIFE +GDYQFEIYRMM++ N N+WR F P +NLYW+HYL++KLLHETSYPR DPDS++I+ EL  L++ +L  K+ S  +L+    YF+ CR
Sbjct:  124 RKIEFDAKEVTQSSEVDASVGADESVLNQSLV-GDPRTKLLELCGQTEVRPFSSFFDPESLEHISKVGEGVYGEVFQANKSSVIKIFPIDGDIPVNGEKQMESVRVYPEVFISKKLTELGFKYRRNRSVNFIQLRKAAIVYGKWPSELTAAWKKYEMEHGSDNECVDFLPKSQEWMILEFDYAGKPLGTMKFSSHREARSVIEQIAISLAAAESALQFEHRDLHWLNVLVKPTKQTKLRYRVDGVGYAVQTEGIQVCIIDFTVSRLCHEGNIVYVDMSNSPEIFECDGDYQFEIYRMMRDMNGNDWRPFRPITNLYWLHYLMEKLLHETSYPRRDPDSQAIQSELTALHDSVLSGKYASVAQLVRSSFYFDTCR 496
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A5K3EQD5 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 431.409 bits (1108), Expect = 1.013e-139
Identity = 207/374 (55.35%), Postives = 277/374 (74.06%), Query Frame = 1 
Query:  853 RKIE-SSQECNDSSSC-TSVGEDS--LSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRIL--KFKSAQELIEKDEYFEKCR 1956
            RKIE  ++E   SS    SVG D   L+ SLV  DP  K+L+LC Q+++R + SFFD  S +  +KVGEGVYGEVF+  + +V+K+FP++GD+ VNGE QM    V+PEVF+SKKLTEL  K +  R+ NF+QL+KA++V GK P  L   WK+++ + G+DNEC+DFL   Q+WM LE+++AG+PL   KF+ + E RS+IEQI ISLA AE+A+QFEHRDLHWLN+LVKPTKQ KLRYR++G  Y     G+ V +IDFTVSR+C + N VY+DMS+ PEIFE +GDYQFEIYRMM++ N N+WR F P +NLYW+HYL++KLLHETSYPR DPDS++I+ EL  L++ +L  K+ S  +L+    YF+ CR
Sbjct:  120 RKIEFDAKEVTQSSEVDASVGADESVLNQSLV-GDPRTKLLELCGQTEVRPFSSFFDPESLEHISKVGEGVYGEVFQANKSSVIKIFPIDGDIPVNGEKQMESVRVYPEVFISKKLTELGFKYRRNRSVNFIQLRKAAIVYGKWPSELTAAWKKYEMEHGSDNECVDFLPKSQEWMILEFDYAGKPLGTMKFSSHREARSVIEQIAISLAAAESALQFEHRDLHWLNVLVKPTKQTKLRYRVDGVGYAVQTEGIQVCIIDFTVSRLCHEGNIVYVDMSNSPEIFECDGDYQFEIYRMMRDMNGNDWRPFRPITNLYWLHYLMEKLLHETSYPRRDPDSQAIQSELTALHDSVLSGKYASVAQLVRSSFYFDTCR 492
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0X3PHE6 (Serine/threonine-protein kinase haspin OS=Schistocephalus solidus OX=70667 GN=HASP PE=4 SV=1)

HSP 1 Score: 429.869 bits (1104), Expect = 2.699e-137
Identity = 209/395 (52.91%), Postives = 284/395 (71.90%), Query Frame = 1 
Query:  793 FVKKKSKLPNAKSSKPWKQM--RKIE-SSQECNDSSSCTS--VGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRIL--KFKSAQELIEKDEYFEKCR 1956
            F  ++ + PN   +   K++  R+IE   QE  ++S   S  V E+S  +  +  DP++K+L+LC Q + RS+ SFFD  + +   K+GEGVYGEVF+ ++G V+KVFPV+GDL VNGE QM    V+PEVF+S++LTEL  K +  R+ NF+QL+KAS+V GK P      WK+++++ G+DNECLDFL   Q+WM LE+++AG+PL   KF  Y E RS+I+QI ISLA AE+A+QFEHRDLHWLN+LVKPTKQ KLRYR+NG +Y     G+ V +IDFTVSR+C + N VY+DMS  PE+FE EGDYQF+IYRMM++ N NNWR F P +NLYW++YL+DKLL++TSYPR DPDS +IE EL  L + +L   +KSA +L+    YF+ CR
Sbjct:  234 FSPRRFRSPNKDQAAKLKRVNARRIEFDVQEVVENSDLNSSYVQEESFLSQSIVGDPKEKLLELCGQVEPRSFSSFFDPETLENIVKIGEGVYGEVFQTHKGTVIKVFPVDGDLPVNGEKQMESSRVYPEVFISRQLTELGFKYRQNRSVNFIQLRKASLVCGKWPSEFTAAWKKYEAEHGSDNECLDFLPRCQEWMILEFDYAGKPLGTVKFTSYREARSVIQQIAISLAAAESALQFEHRDLHWLNVLVKPTKQEKLRYRVNGVSYAVQTEGIHVCIIDFTVSRLCHEGNIVYVDMSKSPEVFECEGDYQFDIYRMMRDMNGNNWRPFRPITNLYWLNYLMDKLLNQTSYPRRDPDSSAIESELAALRDTVLSGSYKSATQLVNLSFYFDNCR 628
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A3Q0KUL5 (Protein kinase domain-containing protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 421.394 bits (1082), Expect = 1.741e-134
Identity = 200/343 (58.31%), Postives = 266/343 (77.55%), Query Frame = 1 
Query:  934 VQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILK--FKSAQELIEKDEYFEKCR 1956
            V  DP +K+L LC Q++I+S+  +FD    ++  K+GEGVYGEVF+  +GNV+K+FPV+G+ LVNGE QM FE+V+PEVFVS+KL+EL  K +  R+ NF QLK+A++VRGKLP+ L   W++++S RG+DNECLDFL  +Q+WM LE EFAGEPLSN +FN   E RS+IEQI +SLA AE+A+QFEHRDLHW N+LV+PT+Q KLRYR+ G +Y     G+ VT+IDFTVSR+C + N VY+DMS+ PEIFE EGDYQF+IYR+M+ +N N+WR F+P SNLYW+HYL+ KLL+ETSYPR DPDS+ +E EL  LY+ +L   + SA +L+    YF+ CR
Sbjct:  245 VVGDPLEKLLRLCGQTEIKSFDEYFDHTIVESMVKIGEGVYGEVFQSPKGNVVKIFPVDGEDLVNGEKQMKFEEVYPEVFVSQKLSELAYKYRRNRSVNFAQLKRATVVRGKLPKALASSWRKYESQRGSDNECLDFLPAEQQWMVLESEFAGEPLSNVRFNTCREARSVIEQIALSLAAAESALQFEHRDLHWHNVLVRPTRQSKLRYRVGGVSYAVFTEGIQVTIIDFTVSRLCHEGNIVYVDMSESPEIFECEGDYQFDIYRIMRENNGNDWRPFHPSSNLYWLHYLMGKLLNETSYPRRDPDSQPVESELRALYDMVLAGDYNSATQLVSSSFYFDSCR 587
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0R3WF59 (Protein kinase domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS9493 PE=4 SV=1)

HSP 1 Score: 412.535 bits (1059), Expect = 1.749e-132
Identity = 202/373 (54.16%), Postives = 275/373 (73.73%), Query Frame = 1 
Query:  853 RKIE-SSQECNDSSSCTSVG--EDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRIL--KFKSAQELIEKDEYFEKCR 1956
            RKIE  ++E  + S  +  G  ++S     +  DP  K+++LC Q+++RS+ SFFD  S +  +K+GEGVYGEVF+  +  V+KVFP++G++ VNGE QM    V+PEVF+SK+LTEL  K +  RT NF+QL++A++V GK P  L   WK+++++ G+DNECLDFL   Q+WM LE+++AG+PL   KF+ Y E RS+IEQI +SLA AE+A+QFEHRDLHWLN+LVKPTKQ KLRYR+NG +Y     G+ V +IDFTVSR+C + N VY+DMSD PEIFE EGDYQFEIYRMM+N N NNWR F P +NLYW+HYL++KLL+ETSYPR DPDS++++ EL  L++ +L   + SA  L+    YF+ CR
Sbjct:  119 RKIEFDAEEVPEISRLSFSGNADESFFNQSIVGDPRTKLMELCGQTEVRSFSSFFDAESLENISKIGEGVYGEVFQANKACVIKVFPIDGNIPVNGEKQMESHRVYPEVFISKQLTELGFKYRQNRTVNFIQLRRAAIVCGKWPAELTAAWKKYEAEHGSDNECLDFLPRSQEWMILEFDYAGKPLGTIKFSSYREARSVIEQIALSLAAAESALQFEHRDLHWLNVLVKPTKQTKLRYRVNGVSYSVQTEGVRVCIIDFTVSRLCHEGNIVYVDMSDSPEIFECEGDYQFEIYRMMRNMNGNNWRPFRPITNLYWLHYLMEKLLNETSYPRRDPDSQAVQSELAALHDSVLSGSYDSATRLVRSSFYFDTCR 491
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: si:dkeyp-26a9.2 (histone H3 associated protein kinase [Source:NCBI gene;Acc:103026235])

HSP 1 Score: 247.669 bits (631), Expect = 1.247e-68
Identity = 135/373 (36.19%), Postives = 209/373 (56.03%), Query Frame = 1 
Query:  850 MRKIESSQECNDSSSCTSVGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN----VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNY--KFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRG-DPDSKSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            + K+ SS+    + S  S+G D       +    +K+   C Q    S+         K  NK+GEG +GEVF     +     LK+ PV G   VNGE Q TF+++  E+ +SK+L+ L+ K    +T+ F+ L     V+G  P  L+  W +F  D+ ++N+  DF   +Q ++ LE+EF G  L N   K +   + +S++ Q+T +LAVAE ++ FEHRDLHW NILVK TK+    + +NG+ Y     G+ V +ID+++SR+ +D  TV  D+S+  E+F G+GDYQFEIYR+MK +N N W E+NP SN+ W+HYL+DKLL      +      +++   L    + IL F+SA + +     F+
Sbjct:  860 LSKLASSRLLYSTMSNASIGPDE------EISDAEKVYQECQQDGPLSFEDCIPPEQMKCCNKIGEGTFGEVFSTINSSNQTVALKIIPVEGSEKVNGEAQKTFDEILHEIIISKELSSLDSKEN-NKTNGFIGLNNLHCVQGCYPSALLKAWDKFDQDKTSENDRPDFFGKEQLFVILEFEFGGSDLENMNGKLSSMAQAKSLLHQVTAALAVAEQSLCFEHRDLHWGNILVKTTKEKHTDFILNGSVYSVETRGVHVNIIDYSLSRLEIDGLTVSCDISNDEELFMGQGDYQFEIYRLMKKENNNCWGEYNPHSNVLWLHYLVDKLLTMKYRCKAQSSQQRALRSSLKSFQSEILSFRSATDALLHCSLFQ 1225
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000394.1 (pep scaffold:Pmarinus_7.0:GL476890:391392:401812:1 gene:ENSPMAG00000000354.1 transcript:ENSPMAT00000000394.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 227.639 bits (579), Expect = 3.540e-68
Identity = 123/328 (37.50%), Postives = 197/328 (60.06%), Query Frame = 1 
Query:  970 CDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRG----NVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNY--KFNGYHEVRSIIEQITISLAVAEAAVQFEH---RDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELI 1926
            C Q    ++  +   +   +  KVGEGVYGEVF++  G    +V KV P+ G +LVN E Q +FE++ PE+ + K+L+ L+ + + +++ NF++L     ++G  P  L++ W +F  ++ +DN+C +F TD Q ++  E+E  G  L  Y  KF+   ++ +++ Q+ ++LAVAE A+ FEH   RDLHW N+LVK TK+ KL YR+ G  +     G+   +ID+T+SRM  D    + +M+    +F+G+GDYQ++IYRMM+N+N NNW  + P +N+ W+HYL  K+LH  +  R    S    LE  +     L F SA EL+
Sbjct:    7 CKQMGPLAFSQWLLSLEGGSCIKVGEGVYGEVFRMCSGRDKVSVFKVVPIEGSVLVNEEPQKSFEEILPEIMICKQLSSLH-EGEHHQSENFIKLNGLRCLQGSYPDRLLEAWNEFHENKLSDNDCPNFFTDSQLFIVFEFEDGGTSLETYQFKFSSMLQMVAVLYQVLVALAVAEEAICFEHSSARDLHWGNVLVKQTKKKKLSYRLFGQTFSMPTHGVQAKIIDYTLSRMEHDGMIKFTNMALDEMLFQGQGDYQYDIYRMMRNENNNNWAAYAPHTNVLWLHYLAGKMLHGVNCRRRRHVSPRSRLE--RFAREALAFPSATELV 331
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: ALK2 (Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins [Source:SGD;Acc:S000000105])

HSP 1 Score: 70.0922 bits (170), Expect = 8.493e-13
Identity = 52/167 (31.14%), Postives = 78/167 (46.71%), Query Frame = 1 
Query: 1327 NECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSR-MCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKN--DNRNNWREFNPRSNLYWIHYLIDKLL 1818
            N+C +   D+   + L +++ G PLS      Y +  SI  Q +  L VAE+  Q EHR+L   +IL+                  GN     VT+ID    R + +D+N       D    F+G G  QFEIY +M++      +W  F PR+NL W+++L   LL
Sbjct:  475 NQCEN---DQNLILYLFFKYQGTPLSRCSNIDYSQALSIFWQCSSILYVAESKFQLEHRNLTLDHILIDSK---------------GN-----VTLIDMKCCRFLNIDNNKASYTRLDHHYFFQGRGTLQFEIYELMRSMLPQPISWATFEPRTNLLWLYHLSSSLL 618
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: ALK1 (Protein kinase; along with its paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins [Source:SGD;Acc:S000002989])

HSP 1 Score: 51.2174 bits (121), Expect = 5.348e-7
Identity = 43/162 (26.54%), Postives = 73/162 (45.06%), Query Frame = 1 
Query: 1363 WMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTV----------YMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLL 1818
            ++ L ++  G P+S      + ++  I       +   E  ++FEHR+L   NIL            I+G    GN     +T+IDF  SR+    + V          +++  D  +I E +  ++FEIY+ M+     +   F P +NLYW++YL   LL
Sbjct:  562 YLYLLFKDHGTPISLISLKNWKQILKIFWSCAGIIHGLEKNLKFEHRNLTLDNIL------------IDGN---GN-----ITIIDFKCSRLQTPQDDVLYLRLDHPLFFLNGKDKSKINEYQYQFEFEIYQSMRILLNMDASAFEPMTNLYWLYYLSRVLL 703
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO31137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYS8])

HSP 1 Score: 83.9593 bits (206), Expect = 1.023e-19
Identity = 37/85 (43.53%), Postives = 58/85 (68.24%), Query Frame = 1 
Query: 1549 KLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYL 1803
            +L Y ++G  +     GL V++IDFT+SR+  +  TV+ D+S+   +F G+GDYQF+IYR M+  NR++W  + P SN+ W+HYL
Sbjct:    3 QLVYMLDGERWTVESRGLCVSLIDFTLSRLRKEGVTVFCDLSEDESMFTGQGDYQFDIYRKMRVHNRDDWAAYKPYSNVLWLHYL 87
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: si:dkeyp-26a9.2 (histone H3 associated protein kinase [Source:NCBI gene;Acc:101174563])

HSP 1 Score: 238.81 bits (608), Expect = 1.050e-65
Identity = 123/338 (36.39%), Postives = 190/338 (56.21%), Query Frame = 1 
Query:  952 QKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN----VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPL--SNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            +K+   C Q     W      + +K   K+GEG +GEVF           LK+ P+ G   VNGEDQ TF ++  EV +SK+L+ L  K    +T+ F+ L     V+G  P   +  W  +   +G++N+  DF + +Q ++ LE+EF G  L  SN         +SI+ Q+T +LAVAE  + FEHRDLHW N+LVK T++ K  + +NG  +     G+ V +ID+++SR+ +D  TV  D+S+  E+F G+GDYQFEIYR+M+ +N N+W  ++P SN+ W+HYL  KLL       G   +K     L++ ++ IL++ SA E +     F+
Sbjct:  872 EKVYAECGQEHPLPWEECILPLRSKGCVKIGEGTFGEVFSTTNAAGETVALKIIPIEGSKKVNGEDQKTFGEILHEVIISKELSSLKEKQH-NQTNGFIGLNDLHCVQGCYPSDFLKAWDAYDRRKGSENDRPDFFSKEQLFIILEFEFGGVDLENSNGTLASLGVAKSILHQVTAALAVAEQELHFEHRDLHWGNVLVKTTRKRKGSFLLNGETHHVETNGVLVRIIDYSLSRLEIDELTVSCDISNDEELFMGQGDYQFEIYRLMRQENGNDWSSYHPHSNVLWLHYLCSKLLSMKYRGSGRKGAKDTREALSRFHDNILQYNSATEALRNCAMFQ 1208
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: si:dkeyp-26a9.2 (histone H3 associated protein kinase [Source:NCBI gene;Acc:101174563])

HSP 1 Score: 238.424 bits (607), Expect = 1.256e-65
Identity = 123/338 (36.39%), Postives = 190/338 (56.21%), Query Frame = 1 
Query:  952 QKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGN----VLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPL--SNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFE 1947
            +K+   C Q     W      + +K   K+GEG +GEVF           LK+ P+ G   VNGEDQ TF ++  EV +SK+L+ L  K    +T+ F+ L     V+G  P   +  W  +   +G++N+  DF + +Q ++ LE+EF G  L  SN         +SI+ Q+T +LAVAE  + FEHRDLHW N+LVK T++ K  + +NG  +     G+ V +ID+++SR+ +D  TV  D+S+  E+F G+GDYQFEIYR+M+ +N N+W  ++P SN+ W+HYL  KLL       G   +K     L++ ++ IL++ SA E +     F+
Sbjct:  821 EKVYAECGQEHPLPWEECILPLRSKGCVKIGEGTFGEVFSTTNAAGETVALKIIPIEGSKKVNGEDQKTFGEILHEVIISKELSSLKEKQH-NQTNGFIGLNDLHCVQGCYPSDFLKAWDAYDRRKGSENDRPDFFSKEQLFIILEFEFGGVDLENSNGTLASLGVAKSILHQVTAALAVAEQELHFEHRDLHWGNVLVKTTRKRKGSFLLNGETHHVETNGVLVRIIDYSLSRLEIDELTVSCDISNDEELFMGQGDYQFEIYRLMRQENGNDWSSYHPHSNVLWLHYLCSKLLSMKYRGSGRKGAKDTREALSRFHDNILQYNSATEALRNCAMFQ 1157
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000001493.1 (SMESG000001493.1)

HSP 1 Score: 1210.28 bits (3130), Expect = 0.000e+0
Identity = 641/641 (100.00%), Postives = 641/641 (100.00%), Query Frame = 1 
Query:   73 MKEKRFTRSATICNNSKILKDNFXXXXXXXXXXXXXXRKRPXXXXXXXXXXXXXELNSPKDVIENVPPISSRLRSRTSCKVNEYDFVNQKIGNYXXXXXXXXXXDDHNQKKPKLSKIDSSLNGLSLPNGNHKSKPITRNASCRIPTKTYSILKSVNNSSDLQPTRYLLRSRSFKAIPPPIHIAIENIFRAPDPPIKPLSEIYKKINFSTSVEKDHNTSFSQLSDCXXXXXXXXXXXXXXRFVKKKSKLPNAKSSKPWKQMRKIESSQECNDSSSCTSVGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFEKCRQNSSSSHGYCADE 1995
            MKEKRFTRSATICNNSKILKDNFNIKSNSNVNLKNKSRKRPSDMSSYDSNNSSMELNSPKDVIENVPPISSRLRSRTSCKVNEYDFVNQKIGNYSLSESSSNLSDDHNQKKPKLSKIDSSLNGLSLPNGNHKSKPITRNASCRIPTKTYSILKSVNNSSDLQPTRYLLRSRSFKAIPPPIHIAIENIFRAPDPPIKPLSEIYKKINFSTSVEKDHNTSFSQLSDCSNNSSTNLSTTLLSRFVKKKSKLPNAKSSKPWKQMRKIESSQECNDSSSCTSVGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFEKCRQNSSSSHGYCADE
Sbjct:    1 MKEKRFTRSATICNNSKILKDNFNIKSNSNVNLKNKSRKRPSDMSSYDSNNSSMELNSPKDVIENVPPISSRLRSRTSCKVNEYDFVNQKIGNYSLSESSSNLSDDHNQKKPKLSKIDSSLNGLSLPNGNHKSKPITRNASCRIPTKTYSILKSVNNSSDLQPTRYLLRSRSFKAIPPPIHIAIENIFRAPDPPIKPLSEIYKKINFSTSVEKDHNTSFSQLSDCSNNSSTNLSTTLLSRFVKKKSKLPNAKSSKPWKQMRKIESSQECNDSSSCTSVGEDSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELELNQLYNRILKFKSAQELIEKDEYFEKCRQNSSSSHGYCADE 641
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000029295.1 (SMESG000029295.1)

HSP 1 Score: 228.409 bits (581), Expect = 6.728e-65
Identity = 121/308 (39.29%), Postives = 181/308 (58.77%), Query Frame = 1 
Query:  913 DSLSASLVQADPEQKILDLCDQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLY----RGNVLKVFPVNGDLLVNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKLPQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILV--KPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLL 1818
            DS   +    D E  +L LC + + +++ S F     K  +K+GEG +GEVF +     + +V+K  PVNG L  NG  Q TF+D+  E+ V+K+L++L       R  NFV+++   +V GK P     +W +    + ++N+     T  QKW+ +++EFAG PL N+K   + +  SI+ Q  +SLA AE  V+FEHRDLHW NILV  +     +L Y ++G +Y  N  G+  TVID+T SR+    N VY DMS   +IF G GD QF++YR M+  N+N W  FNP++N++W+ YL +KLL
Sbjct:  271 DSFWEAYNVNDSESVVLKLCGKERYQNFASVFPMKKRKEISKLGEGSFGEVFSIVDSEDKLSVIKFIPVNGSLYYNGGPQTTFDDIISEIVVAKELSDLR-IGTTNRCRNFVKMENVFLVSGKFPAYFQKEWDKSNKLKTSENDNPKKFTSSQKWILIQFEFAGCPLENFKIESFAQAYSILLQTCLSLACAEYYVEFEHRDLHWGNILVLKRDLDDSELTYMLDGKDYQINHHGVLSTVIDYTFSRIKKGINLVYSDMSKDQDIFLGTGDPQFDVYRQMQQHNKNEWSHFNPKTNIFWLTYLGNKLL 577
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000029289.1 (SMESG000029289.1)

HSP 1 Score: 126.331 bits (316), Expect = 8.946e-33
Identity = 63/141 (44.68%), Postives = 91/141 (64.54%), Query Frame = 1 
Query: 1402 SNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILV--KPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLL 1818
            ++++   + +  SI+ Q  +SLA AE  V+FEHRDLHW NILV  +     +L Y ++G +Y  N  G+  TVID+T SR+    N VY DMS   +IF G GD QF++YR M+  N+N W  FNP++N++W+ YL +KLL
Sbjct:   28 NDFEIESFAQAYSILLQTCLSLACAEYYVEFEHRDLHWGNILVLKRDLDDSELTYMLDGKDYQINHHGVLSTVIDYTFSRIKKGINLVYSDMSKDQDIFLGTGDPQFDVYRQMQQHNKNEWSHFNPKTNIFWLTYLGNKLL 168
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000029289.1 (SMESG000029289.1)

HSP 1 Score: 126.331 bits (316), Expect = 2.382e-32
Identity = 68/158 (43.04%), Postives = 94/158 (59.49%), Query Frame = 1 
Query: 1351 DKQKWMALEYEFAGEPLSNYKFNGYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILV--KPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLL 1818
            D++KW+      +     N   N      SI+ Q  +SLA AE  V+FEHRDLHW NILV  +     +L Y ++G +Y  N  G+  TVID+T SR+    N VY DMS   +IF G GD QF++YR M+  N+N W  FNP++N++W+ YL +KLL
Sbjct:   45 DRKKWLIQAKRRSRWIKKNQGMNDSFWAYSILLQTCLSLACAEYYVEFEHRDLHWGNILVLKRDLDDSELTYMLDGKDYQINHHGVLSTVIDYTFSRIKKGINLVYSDMSKDQDIFLGTGDPQFDVYRQMQQHNKNEWSHFNPKTNIFWLTYLGNKLL 202
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000029289.1 (SMESG000029289.1)

HSP 1 Score: 125.176 bits (313), Expect = 6.784e-32
Identity = 63/135 (46.67%), Postives = 87/135 (64.44%), Query Frame = 1 
Query: 1420 GYHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILV--KPTKQIKLRYRINGTNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEIYRMMKNDNRNNWREFNPRSNLYWIHYLIDKLL 1818
             + +  SI+ Q  +SLA AE  V+FEHRDLHW NILV  +     +L Y ++G +Y  N  G+  TVID+T SR+    N VY DMS   +IF G GD QF++YR M+  N+N W  FNP++N++W+ YL +KLL
Sbjct:   74 SFAQAYSILLQTCLSLACAEYYVEFEHRDLHWGNILVLKRDLDDSELTYMLDGKDYQINHHGVLSTVIDYTFSRIKKGINLVYSDMSKDQDIFLGTGDPQFDVYRQMQQHNKNEWSHFNPKTNIFWLTYLGNKLL 208
The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
HASPIN2.713e-6737.68histone H3 associated protein kinase [Source:HGNC ... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hasp-16.035e-5131.82HASPin kinase related [Source:UniProtKB/TrEMBL;Ac... [more]
hasp-26.897e-4831.88HASPin kinase related [Source:UniProtKB/TrEMBL;Ac... [more]
H12I13.15.543e-1024.14pep chromosome:WBcel235:II:6061977:6067166:-1 gene... [more]
C06E4.51.348e-933.00pep chromosome:WBcel235:IV:7254990:7255909:1 gene:... [more]
C26E6.15.987e-932.98pep chromosome:WBcel235:III:4956891:4957539:1 gene... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Haspin6.393e-6332.79gene:FBgn0046706 transcript:FBtr0113784[more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
si:dkeyp-26a9.24.160e-7139.41si:dkeyp-26a9.2 [Source:ZFIN;Acc:ZDB-GENE-090313-3... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Haspin5.402e-6736.54histone H3 associated protein kinase [Source:MGI S... [more]
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q2KIP2|HASP_BOVIN6.790e-6836.87Serine/threonine-protein kinase haspin OS=Bos taur... [more]
sp|Q8TF76|HASP_HUMAN1.303e-6637.68Serine/threonine-protein kinase haspin OS=Homo sap... [more]
sp|Q9Z0R0|HASP_MOUSE3.741e-6636.54Serine/threonine-protein kinase haspin OS=Mus musc... [more]
sp|P83103|HASP_DROME6.408e-6232.79Putative serine/threonine-protein kinase haspin ho... [more]
sp|O80528|HASP_ARATH3.067e-4933.24Serine/threonine-protein kinase haspin homolog OS=... [more]
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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3P6I3F19.317e-14055.35Protein kinase domain-containing protein OS=Mesoce... [more]
A0A5K3EQD51.013e-13955.35Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A0X3PHE62.699e-13752.91Serine/threonine-protein kinase haspin OS=Schistoc... [more]
A0A3Q0KUL51.741e-13458.31Protein kinase domain-containing protein OS=Schist... [more]
A0A0R3WF591.749e-13254.16Protein kinase domain-containing protein OS=Taenia... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
si:dkeyp-26a9.21.247e-6836.19histone H3 associated protein kinase [Source:NCBI ... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000000394.13.540e-6837.50pep scaffold:Pmarinus_7.0:GL476890:391392:401812:1... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
ALK28.493e-1331.14Protein kinase; along with its paralog, ALK1, requ... [more]
ALK15.348e-726.54Protein kinase; along with its paralog, ALK2, requ... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO311371.023e-1943.53Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
si:dkeyp-26a9.21.050e-6536.39histone H3 associated protein kinase [Source:NCBI ... [more]
si:dkeyp-26a9.21.256e-6536.39histone H3 associated protein kinase [Source:NCBI ... [more]
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BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000001493.10.000e+0100.00SMESG000001493.1[more]
SMESG000029295.16.728e-6539.29SMESG000029295.1[more]
SMESG000029289.18.946e-3344.68SMESG000029289.1[more]
SMESG000029289.12.382e-3243.04SMESG000029289.1[more]
SMESG000029289.16.784e-3246.67SMESG000029289.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033865 ID=SMED30033865|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2388bp
TATCAATTATGAAATTTTTATAATAAAATTAATTGTAAATATCTGGTGTC
GAATTCAGATTAATTTTATTCAATGAAAGAAAAGCGTTTCACTCGCAGTG
CTACTATATGCAATAATTCAAAAATTTTAAAAGATAATTTTAATATTAAA
TCGAATTCAAATGTGAATTTAAAAAATAAATCTCGCAAAAGACCAAGTGA
TATGAGCTCTTATGATTCAAATAATAGCTCAATGGAATTGAACAGTCCGA
AAGATGTTATTGAGAATGTTCCACCCATATCATCTCGTTTAAGAAGTAGG
ACCTCATGTAAAGTTAATGAATATGATTTTGTGAATCAAAAGATTGGTAA
TTATTCATTGTCTGAATCTTCCAGTAATTTATCAGATGATCATAATCAAA
AGAAACCTAAATTATCTAAAATTGATTCTTCACTTAACGGTCTTTCTTTA
CCAAATGGTAACCATAAAAGTAAGCCAATTACTAGAAATGCATCATGTAG
AATTCCAACAAAAACGTACAGCATTTTAAAATCTGTAAATAATTCTTCTG
ACTTACAGCCAACTAGATATTTATTAAGGTCCAGAAGTTTTAAAGCAATA
CCACCACCTATCCATATTGCAATTGAAAACATATTTAGGGCCCCAGATCC
TCCTATTAAACCATTATCAGAAATATACAAGAAGATTAATTTTTCTACTT
CAGTAGAAAAAGATCATAATACTAGCTTCTCACAATTATCAGATTGTAGT
AACAACAGTAGTACAAATTTATCTACAACTTTACTATCGAGGTTTGTCAA
AAAAAAGTCAAAATTACCAAATGCTAAAAGCTCAAAACCCTGGAAACAAA
TGCGTAAGATCGAATCAAGTCAGGAATGCAATGATAGTTCTAGCTGTACA
TCTGTTGGAGAAGATAGTTTGAGCGCTTCACTTGTTCAAGCGGATCCAGA
ACAAAAAATTCTTGATTTATGCGATCAATCACAAATCAGATCTTGGTGTA
GTTTCTTTGATGACGTATCCAACAAAACAACTAATAAAGTCGGTGAAGGA
GTTTATGGAGAAGTTTTTAAATTGTATCGGGGAAATGTGCTTAAAGTGTT
TCCGGTCAATGGAGACTTACTCGTAAATGGAGAAGATCAAATGACGTTTG
AAGATGTGTTTCCTGAGGTGTTTGTGTCTAAAAAATTGACAGAATTAAAT
GGAAAGAACAAATTGTATAGGACATCGAATTTTGTACAGCTGAAAAAGGC
ATCGATGGTTCGGGGTAAATTACCACAAATTCTCATAGACCAATGGAAAC
AATTCAAATCAGATAGGGGGACTGATAACGAATGCTTAGATTTTCTCACT
GATAAACAGAAATGGATGGCTCTTGAATATGAATTTGCAGGAGAACCGTT
ATCGAATTACAAGTTCAATGGTTATCACGAGGTTAGAAGTATTATTGAGC
AAATCACTATCTCTCTTGCTGTGGCAGAAGCCGCTGTCCAGTTTGAGCAT
CGTGATCTTCACTGGCTGAATATATTGGTGAAACCGACTAAGCAAATAAA
ATTGCGGTATAGAATTAATGGTACCAATTACATCGGGAATTGTTTCGGTC
TATTTGTAACAGTAATTGATTTTACCGTATCAAGGATGTGCGTTGATAGC
AACACCGTTTATATGGATATGTCTGATTGTCCAGAAATTTTCGAAGGTGA
AGGAGATTATCAATTCGAGATCTATCGTATGATGAAAAATGACAATAGAA
ATAATTGGCGCGAATTCAATCCCCGAAGCAATCTCTATTGGATTCATTAT
CTAATCGATAAATTACTCCACGAAACCTCGTATCCCCGCGGCGATCCTGA
CTCTAAATCAATTGAACTGGAATTGAATCAGCTCTACAACAGAATCCTCA
AATTTAAATCAGCTCAAGAATTGATTGAGAAAGATGAATATTTTGAGAAA
TGCCGACAGAACAGCAGTAGTAGTCATGGTTATTGTGCTGATGAATAAGG
AGGATCAGTCACCAAATTTTATGTCGTGTGTATGTGTGTGTATGTGTGTA
AAGAGAGAGAGAATAAACAGTGATCTTGTATATTGATTGTTTATCTGACT
TGTGTTGTAATATTTGTATTCAAGTAGTGCTTATTGACACCGGCACCATC
ATCATCATATTTGACCGTATTAAACTCTCGATCAATTGAGACGACTGCTC
GGCAAGTTTTGCATTTATTTTTTATTAGAAAACAATTTACATGTTTGCAA
ATCACCGATTGGTCAAACTGTTGTGTAATAGTGCATTTTGTGACAATAAC
TATTATTGAACCGAACGTTTTTTCAGTGCATTAGATCTGTCATTGTAAGT
TTTTAAGTAAAATGTGATAATTTTAGGGATAATTTTCC
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protein sequence of SMED30033865-orf-1

>SMED30033865-orf-1 ID=SMED30033865-orf-1|Name=SMED30033865-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=642bp
MKEKRFTRSATICNNSKILKDNFNIKSNSNVNLKNKSRKRPSDMSSYDSN
NSSMELNSPKDVIENVPPISSRLRSRTSCKVNEYDFVNQKIGNYSLSESS
SNLSDDHNQKKPKLSKIDSSLNGLSLPNGNHKSKPITRNASCRIPTKTYS
ILKSVNNSSDLQPTRYLLRSRSFKAIPPPIHIAIENIFRAPDPPIKPLSE
IYKKINFSTSVEKDHNTSFSQLSDCSNNSSTNLSTTLLSRFVKKKSKLPN
AKSSKPWKQMRKIESSQECNDSSSCTSVGEDSLSASLVQADPEQKILDLC
DQSQIRSWCSFFDDVSNKTTNKVGEGVYGEVFKLYRGNVLKVFPVNGDLL
VNGEDQMTFEDVFPEVFVSKKLTELNGKNKLYRTSNFVQLKKASMVRGKL
PQILIDQWKQFKSDRGTDNECLDFLTDKQKWMALEYEFAGEPLSNYKFNG
YHEVRSIIEQITISLAVAEAAVQFEHRDLHWLNILVKPTKQIKLRYRING
TNYIGNCFGLFVTVIDFTVSRMCVDSNTVYMDMSDCPEIFEGEGDYQFEI
YRMMKNDNRNNWREFNPRSNLYWIHYLIDKLLHETSYPRGDPDSKSIELE
LNQLYNRILKFKSAQELIEKDEYFEKCRQNSSSSHGYCADE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR024604GSG2_C
IPR000719Prot_kinase_dom
IPR011009Kinase-like_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0016301kinase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableSMARTSM01331DUF3635_2coord: 537..624
e-value: 9.2E-34
score: 128.2
NoneNo IPR availablePFAMPF12330Haspin_kinasecoord: 218..622
e-value: 9.3E-59
score: 199.2
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 302..438
e-value: 2.3E-31
score: 110.7
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 439..625
e-value: 9.1E-60
score: 203.3
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 30..69
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 44..59
NoneNo IPR availablePANTHERPTHR24419INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASEcoord: 26..626
NoneNo IPR availablePANTHERPTHR24419:SF18SERINE/THREONINE-PROTEIN KINASE HASPINcoord: 26..626
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 317..641
score: 10.224
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 319..546