N-glycosylase/DNA lyase

Overview
NameN-glycosylase/DNA lyase
Smed IDSMED30033852
Length (bp)1073
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of N-glycosylase/DNA lyase (SMED30033852) t-SNE clustered cells

Violin plots show distribution of expression levels for N-glycosylase/DNA lyase (SMED30033852) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of N-glycosylase/DNA lyase (SMED30033852) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for N-glycosylase/DNA lyase (SMED30033852) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30033852

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30033852SMESG000010115.1 SMESG000001427.1 SmedASXL_011691SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Human
Match: OGG1 (8-oxoguanine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:8125])

HSP 1 Score: 205.682 bits (522), Expect = 6.895e-63
Identity = 117/312 (37.50%), Postives = 176/312 (56.41%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIA-------QLKQEPDYNVYFYSKNEDFTKIKIFL---NNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPV-HFQE 967
            + E+ L+L L  GQ+FRW E     W    +G +A       Q +++    VY   K++        L     YF+   +L++    W   D++F ++++ F G+RLLRQ P+E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FPS+  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+D+HM+ + ++ Y+ H       AK  +P   +++   F  +W P +GWAQ ++F++DL+   H QE
Sbjct:   30 RSELRLDLVLPSGQSFRWREQSPAHW----SGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWH--PTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQE 331
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Human
Match: OGG1 (8-oxoguanine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:8125])

HSP 1 Score: 196.052 bits (497), Expect = 2.101e-59
Identity = 111/298 (37.25%), Postives = 166/298 (55.70%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIA-------QLKQEPDYNVYFYSKNEDFTKIKIFL---NNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLI 928
            + E+ L+L L  GQ+FRW E     W    +G +A       Q +++    VY   K++        L     YF+   +L++    W   D++F ++++ F G+RLLRQ P+E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FPS+  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+D+HM+ + ++ Y+ H       AK  +P   +++   F  +W P +GWAQ +
Sbjct:   30 RSELRLDLVLPSGQSFRWREQSPAHW----SGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWH--PTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAV 317
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Human
Match: OGG1 (8-oxoguanine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:8125])

HSP 1 Score: 195.282 bits (495), Expect = 3.583e-59
Identity = 111/296 (37.50%), Postives = 165/296 (55.74%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIA-------QLKQEPDYNVYFYSKNEDFTKIKIFL---NNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQ 922
            + E+ L+L L  GQ+FRW E     W    +G +A       Q +++    VY   K++        L     YF+   +L++    W   D++F ++++ F G+RLLRQ P+E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FPS+  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+D+HM+ + ++ Y+ H       AK  +P   +++   F  +W P +GWAQ
Sbjct:   30 RSELRLDLVLPSGQSFRWREQSPAHW----SGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWH--PTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQ 315
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Human
Match: OGG1 (8-oxoguanine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:8125])

HSP 1 Score: 195.282 bits (495), Expect = 8.464e-59
Identity = 111/298 (37.25%), Postives = 166/298 (55.70%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIA-------QLKQEPDYNVYFYSKNEDFTKIKIFL---NNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLI 928
            + E+ L+L L  GQ+FRW E     W    +G +A       Q +++    VY   K++        L     YF+   +L++    W   D++F ++++ F G+RLLRQ P+E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FPS+  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+D+HM+ + ++ Y+ H       AK  +P   +++   F  +W P +GWAQ +
Sbjct:   30 RSELRLDLVLPSGQSFRWREQSPAHW----SGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTS--QAKGPSPQTNKELGNFFRSLWGPYAGWAQAL 317
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Human
Match: OGG1 (8-oxoguanine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:8125])

HSP 1 Score: 195.282 bits (495), Expect = 3.381e-58
Identity = 111/296 (37.50%), Postives = 165/296 (55.74%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIA-------QLKQEPDYNVYFYSKNEDFTKIKIFL---NNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQ 922
            + E+ L+L L  GQ+FRW E     W    +G +A       Q +++    VY   K++        L     YF+   +L++    W   D++F ++++ F G+RLLRQ P+E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FPS+  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+D+HM+ + ++ Y+ H       AK  +P   +++   F  +W P +GWAQ
Sbjct:   30 RSELRLDLVLPSGQSFRWREQSPAHW----SGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTS--QAKGPSPQTNKELGNFFRSLWGPYAGWAQ 315
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Fly
Match: Ogg1 (gene:FBgn0027864 transcript:FBtr0071223)

HSP 1 Score: 184.882 bits (468), Expect = 2.721e-55
Identity = 112/299 (37.46%), Postives = 165/299 (55.18%), Query Frame = 2 
Query:   77 EINLNLTLSCGQAFRWE-LCGGEWRCGFNGFIAQ----LKQEPD---YNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSK-ISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDL 946
            E +L  TL  GQ+FRW  +C G  R  + G +      L+QE     Y  Y  S           +++Y R    L    K W+  D+ F K +SK    +RLL Q P EN+FSF+CS NNNIKRI+ ++     TFG+K    +  D +  +P      D+  E+L   LR   FGYRAK+I +T   ++  GG++  + L++  FE AR+ L  L G+G KVADC+ L S+ HLE+VP+DIH++++ + +Y  H   Q    K+VT  IYE++ K F  +    +GWAQ I+F++DL
Sbjct:   33 ECDLERTLLGGQSFRWRSICDGN-RTKYGGVVFNTYWVLQQEESFITYEAYGTSSPLATKDYSSLISDYLRVDFDLKVNQKDWLSKDDNFVKFLSKP---VRLLSQEPFENIFSFLCSQNNNIKRISSMIEWFCATFGTKIGHFNGAD-AYTFPTINRFHDIPCEDLNAQLRAAKFGYRAKFIAQTLQEIQKKGGQNWFISLKSMPFEKAREELTLLPGIGYKVADCICLMSMGHLESVPVDIHIYRIAQNYYLPHLTGQ----KNVTKKIYEEVSKHFQKLHGKYAGWAQAILFSADL 322
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Zebrafish
Match: ogg1 (8-oxoguanine DNA glycosylase [Source:ZFIN;Acc:ZDB-GENE-070112-932])

HSP 1 Score: 190.66 bits (483), Expect = 8.155e-57
Identity = 125/359 (34.82%), Postives = 182/359 (50.70%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPD---YNVYFYSKN---EDFTKIKI-------------------------------------FLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPVHFQEKKQISNLKRKIENNLD 1015
            + E+ L+LTL CGQ FRW E     W     G +  L Q  D   Y VY ++ N   E+  K K+                                      L +YF+    L +  K+W   D +F   +  F G+RLLRQ PVE LFSFICSSNN+I RI  +V  L  T G+     DD    + Y  FPS+ DL+   +E  LR LGFGYRA+++++++  + N+     L  LR+  +  AR  L  L GVG KVADCV L SLD  E +P+D H++++ K+ Y  +F     + K++T  +Y++I   +  +W P +GWAQ ++F +DLK   FQ+ K+    + K E  +D
Sbjct:   21 RSELRLDLTLGCGQTFRWRETADSHWTGVMRGKVWTLTQTEDTLWYYVYSHNNNPGPENRQKGKVEEEEQLLGKMSKRTTCIKQEDEGLCTVLSEPDKKEEELLRDYFQLDVKLGDLYKNWSTVDPHFKHTANIFTGVRLLRQDPVECLFSFICSSNNHISRIQGMVERLCQTLGTLLCKLDD----VAYHDFPSLQDLTDPCVEMRLRDLGFGYRARFLQQSSQMIMNSHHPDWLQSLRSTPYLQARDALRTLPGVGLKVADCVCLMSLDKFEALPVDTHVWQIAKRDY--NFAPGT-SQKTLTDRVYKEIGDFYRKLWGPYAGWAQSVLFCADLK--KFQKLKEEVLSEDKTELKID 370
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Zebrafish
Match: ogg1 (8-oxoguanine DNA glycosylase [Source:ZFIN;Acc:ZDB-GENE-070112-932])

HSP 1 Score: 131.339 bits (329), Expect = 4.782e-35
Identity = 90/261 (34.48%), Postives = 123/261 (47.13%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPD---YNVYFYSKN---EDFTKIKI-------------------------------------FLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKV 721
            + E+ L+LTL CGQ FRW E     W     G +  L Q  D   Y VY ++ N   E+  K K+                                      L +YF+    L +  K+W   D +F   +  F G+RLLRQ PVE LFSFICSSNN+I RI  +V  L  T G+     DD    + Y  FPS+ DL+   +E  LR LGFGYRA+++++++  + N+     L  LR+  +  AR  L  L GVG KV
Sbjct:   21 RSELRLDLTLGCGQTFRWRETADSHWTGVMRGKVWTLTQTEDTLWYYVYSHNNNPGPENRQKGKVEEEEQLLGKMSKRTTCIKQEDEGLCTVLSEPDKKEEELLRDYFQLDVKLGDLYKNWSTVDPHFKHTANIFTGVRLLRQDPVECLFSFICSSNNHISRIQGMVERLCQTLGTLLCKLDD----VAYHDFPSLQDLTDPCVEMRLRDLGFGYRARFLQQSSQMIMNSHHPDWLQSLRSTPYLQARDALRTLPGVGLKV 277
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Xenopus
Match: hs3st3a1 (heparan sulfate-glucosamine 3-sulfotransferase 3A1 [Source:Xenbase;Acc:XB-GENE-989270])

HSP 1 Score: 182.185 bits (461), Expect = 5.932e-53
Identity = 96/248 (38.71%), Postives = 145/248 (58.47%), Query Frame = 2 
Query:  215 KNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPVH 958
            K+ D  K +  L +YF+   SL    + W  SD  F +++++F GIR+LRQ P E LFSFIC+SNNNI RIT ++  +  + G +    D    S  Y  FP++ +L+ E  E  LR LGFGYRA+++ ++A  + +      L  LR   +E+A+  L +L GVG+KVADCV L +LD  E VP+D H+++V K+ Y           K++T  +Y +    F+ +W P +GWAQ ++F S+LK  H
Sbjct:  167 KDTDCKKDQEILEDYFQLNISLRTLYQHWESSDPNFQRVAQDFPGIRILRQDPTECLFSFICTSNNNISRITGMIERVCCSLGQRLCQLD----SDVYHTFPTLQELAAEGTEAKLRDLGFGYRARFVSESARTILSKHCPDWLESLRLVPYEEAKTALCSLPGVGAKVADCVCLMALDKPEAVPVDTHVWQVAKRDYLPQLGS---GNKTLTDRVYRETGDFFHNLWGPYAGWAQSVLFCSELKKFH 407
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Xenopus
Match: hs3st3a1 (heparan sulfate-glucosamine 3-sulfotransferase 3A1 [Source:Xenbase;Acc:XB-GENE-989270])

HSP 1 Score: 181.8 bits (460), Expect = 6.260e-53
Identity = 96/248 (38.71%), Postives = 145/248 (58.47%), Query Frame = 2 
Query:  215 KNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPVH 958
            K+ D  K +  L +YF+   SL    + W  SD  F +++++F GIR+LRQ P E LFSFIC+SNNNI RIT ++  +  + G +    D    S  Y  FP++ +L+ E  E  LR LGFGYRA+++ ++A  + +      L  LR   +E+A+  L +L GVG+KVADCV L +LD  E VP+D H+++V K+ Y           K++T  +Y +    F+ +W P +GWAQ ++F S+LK  H
Sbjct:  167 KDTDCKKDQEILEDYFQLNISLRTLYQHWESSDPNFQRVAQDFPGIRILRQDPTECLFSFICTSNNNISRITGMIERVCCSLGQRLCQLD----SDVYHTFPTLQELAAEGTEAKLRDLGFGYRARFVSESARTILSKHCPDWLESLRLVPYEEAKTALCSLPGVGAKVADCVCLMALDKPEAVPVDTHVWQVAKRDYLPQLGS---GNKTLTDRVYRETGDFFHNLWGPYAGWAQSVLFCSELKKFH 407
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Mouse
Match: Ogg1 (8-oxoguanine DNA-glycosylase 1 [Source:MGI Symbol;Acc:MGI:1097693])

HSP 1 Score: 208.379 bits (529), Expect = 3.933e-64
Identity = 110/301 (36.54%), Postives = 171/301 (56.81%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPD--YNVYFYSKNEDFTKIKI----FLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            + E+ L+L L+ GQ+FRW E     W       +  L Q  D  Y   +   +   ++  +     L+ YF+   SL++    W   D++F ++++ F G+RLLRQ P E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FP++  L+    E  LR+LG GYRA+Y++ +A   LE  GG + L +LR   +E+A K L  L GVG+KVADC+ L +LD  + VP+D+H++++  + Y  H   +   AK  +P+  +++   F  +W P +GWAQ ++F++DL+
Sbjct:   30 RSELRLDLVLASGQSFRWKEQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDDSQVSRPTLEELETLHKYFQLDVSLAQLYSHWASVDSHFQRVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPNLHALAGPEAETHLRKLGLGYRARYVRASAKAILEEQGGPAWLQQLRVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHRDYGWH--PKTSQAKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLR 324
[Close]
BLAST of N-glycosylase/DNA lyase vs. UniProt/SwissProt
Match: sp|O08760|OGG1_MOUSE (N-glycosylase/DNA lyase OS=Mus musculus OX=10090 GN=Ogg1 PE=1 SV=2)

HSP 1 Score: 208.379 bits (529), Expect = 2.751e-63
Identity = 110/301 (36.54%), Postives = 171/301 (56.81%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPD--YNVYFYSKNEDFTKIKI----FLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            + E+ L+L L+ GQ+FRW E     W       +  L Q  D  Y   +   +   ++  +     L+ YF+   SL++    W   D++F ++++ F G+RLLRQ P E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FP++  L+    E  LR+LG GYRA+Y++ +A   LE  GG + L +LR   +E+A K L  L GVG+KVADC+ L +LD  + VP+D+H++++  + Y  H   +   AK  +P+  +++   F  +W P +GWAQ ++F++DL+
Sbjct:   30 RSELRLDLVLASGQSFRWKEQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDDSQVSRPTLEELETLHKYFQLDVSLAQLYSHWASVDSHFQRVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPNLHALAGPEAETHLRKLGLGYRARYVRASAKAILEEQGGPAWLQQLRVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHRDYGWH--PKTSQAKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLR 324
[Close]
BLAST of N-glycosylase/DNA lyase vs. UniProt/SwissProt
Match: sp|O15527|OGG1_HUMAN (N-glycosylase/DNA lyase OS=Homo sapiens OX=9606 GN=OGG1 PE=1 SV=2)

HSP 1 Score: 205.682 bits (522), Expect = 3.311e-62
Identity = 117/312 (37.50%), Postives = 176/312 (56.41%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIA-------QLKQEPDYNVYFYSKNEDFTKIKIFL---NNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPV-HFQE 967
            + E+ L+L L  GQ+FRW E     W    +G +A       Q +++    VY   K++        L     YF+   +L++    W   D++F ++++ F G+RLLRQ P+E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FPS+  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+D+HM+ + ++ Y+ H       AK  +P   +++   F  +W P +GWAQ ++F++DL+   H QE
Sbjct:   30 RSELRLDLVLPSGQSFRWREQSPAHW----SGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDD----VTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWH--PTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQE 331
[Close]
BLAST of N-glycosylase/DNA lyase vs. UniProt/SwissProt
Match: sp|O70249|OGG1_RAT (N-glycosylase/DNA lyase OS=Rattus norvegicus OX=10116 GN=Ogg1 PE=2 SV=1)

HSP 1 Score: 202.216 bits (513), Expect = 7.095e-61
Identity = 110/301 (36.54%), Postives = 168/301 (55.81%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPD--YNVYFYSKNEDFTKIKI----FLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYW-LENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            + E+ L+L L+ GQ+FRW E     W       +  L Q  D  Y   +        +  +     L+ YF+   SL++    W   D++F  +++ F G+RLLRQ P E LFSFICSSNNNI RIT +V  L   FG +    DD    + Y  FP++  L+   +E  LR+LG GYRA+Y+  +A   LE  GG + L +LR  S+E+A K L  L GVG+KVADC+ L +LD  + VP+DIH++++  + Y   +  +    K  +P+  +++   F  +W P +GWAQ ++F++DL+
Sbjct:   30 RSELRLDLVLASGQSFRWREQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDKGQVGRPTLEELETLHKYFQLDVSLTQLYSHWASVDSHFQSVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLVQLDD----VTYHGFPNLHALAGPEVETHLRKLGLGYRARYVCASAKAILEEQGGPAWLQQLRVASYEEAHKALCTLPGVGTKVADCICLMALDKPQAVPVDIHVWQIAHRDYG--WQPKTSQTKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLR 324
[Close]
BLAST of N-glycosylase/DNA lyase vs. UniProt/SwissProt
Match: sp|Q9V3I8|OGG1_DROME (N-glycosylase/DNA lyase OS=Drosophila melanogaster OX=7227 GN=Ogg1 PE=2 SV=2)

HSP 1 Score: 184.882 bits (468), Expect = 2.728e-54
Identity = 112/299 (37.46%), Postives = 165/299 (55.18%), Query Frame = 2 
Query:   77 EINLNLTLSCGQAFRWE-LCGGEWRCGFNGFIAQ----LKQEPD---YNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSK-ISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDL 946
            E +L  TL  GQ+FRW  +C G  R  + G +      L+QE     Y  Y  S           +++Y R    L    K W+  D+ F K +SK    +RLL Q P EN+FSF+CS NNNIKRI+ ++     TFG+K    +  D +  +P      D+  E+L   LR   FGYRAK+I +T   ++  GG++  + L++  FE AR+ L  L G+G KVADC+ L S+ HLE+VP+DIH++++ + +Y  H   Q    K+VT  IYE++ K F  +    +GWAQ I+F++DL
Sbjct:   33 ECDLERTLLGGQSFRWRSICDGN-RTKYGGVVFNTYWVLQQEESFITYEAYGTSSPLATKDYSSLISDYLRVDFDLKVNQKDWLSKDDNFVKFLSKP---VRLLSQEPFENIFSFLCSQNNNIKRISSMIEWFCATFGTKIGHFNGAD-AYTFPTINRFHDIPCEDLNAQLRAAKFGYRAKFIAQTLQEIQKKGGQNWFISLKSMPFEKAREELTLLPGIGYKVADCICLMSMGHLESVPVDIHIYRIAQNYYLPHLTGQ----KNVTKKIYEEVSKHFQKLHGKYAGWAQAILFSADL 322
[Close]
BLAST of N-glycosylase/DNA lyase vs. UniProt/SwissProt
Match: sp|P53397|OGG1_YEAST (N-glycosylase/DNA lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=OGG1 PE=1 SV=1)

HSP 1 Score: 162.54 bits (410), Expect = 2.618e-45
Identity = 113/330 (34.24%), Postives = 167/330 (50.61%), Query Frame = 2 
Query:   68 NKVEINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLK--QEPDYNVYFYSKNED-----FTKI---------KIFLNNYFRCQESLSEKIKS-WILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLE--------LRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYA-----SHFDQQILNAKSVTPIIYEKIRKVFNVI-------WHPNSGWAQLIIFASDL 946
            NK E+ L   L  GQ+FRW      W    N +   +K  Q+  Y+V    ++E+     F  +         K  L  YFR   SL     + WI SD  F+K+S    GIR+L Q P E L SFICSSNNNI RIT++  +L   FG+     D     + Y +FP+ ++L+    E  LR+LGFGYRAKYI +TA  L N+  E+ +           ++  +ED R+ LM+ +GVG KVADCV L  L     VP+D+H+ ++ K+ Y      +H  +++    +  PI  +KI    + I       W   +GWAQ ++F+ ++
Sbjct:   11 NKSELCLANVLQAGQSFRWI-----WDEKLNQYSTTMKIGQQEKYSVVILRQDEENEILEFVAVGDCGNQDALKTHLMKYFRLDVSLKHLFDNVWIPSDKAFAKLSPQ--GIRILAQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTID----GVAYHSFPTSEELTSRATEAKLRELGFGYRAKYIIETARKLVNDKAEANITSDTTYLQSICKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQISANKNHL-KELRTKYNALPISRKKINLELDHIRLMLFKKWGSYAGWAQGVLFSKEI 328
[Close]
BLAST of N-glycosylase/DNA lyase vs. TrEMBL
Match: A0A0K2SVA8 (ENDO3c domain-containing protein OS=Lepeophtheirus salmonis OX=72036 PE=4 SV=1)

HSP 1 Score: 233.032 bits (593), Expect = 1.256e-70
Identity = 137/318 (43.08%), Postives = 194/318 (61.01%), Query Frame = 2 
Query:   68 NKVEINLNLTLSCGQAFRW----ELCGGEWRCGFNGFIAQLKQEPD---YNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIE-NLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPVHFQEKKQISNLKRK 997
            +K E+ L++TL CGQ+FRW    E C   W   +   I  LKQ+ D   +  Y YSK E     +  L +YF+    L    K W   D  FSK++K++ G+R+LRQ PVEN+FSFICSSNNNIKRI+ +V  ++  +GS  +L   NDK   Y +FP+V+ L+ + N+EE+LR  GFGYRA YI KTA  L  NG E  LL+LR  S++DA++ L+ L GVG KVADC+LL SLD    +P+D HMF++  ++Y  H    ++  KSV   IY +I   F  ++   +GWA  ++F++DLK  H Q  K   +++ K
Sbjct:   16 SKNELRLDITLKCGQSFRWSESDESC---WTGAWRNKIWTLKQDSDLIYFKAYPYSKGEVLENSQQ-LQDYFQLNVKLDPLYKEWSKVDKQFSKVAKHYPGVRMLRQDPVENVFSFICSSNNNIKRISSMVEHMSTEYGS--YLGSINDKD--YHSFPTVEQLNKDKNIEENLRSNGFGYRAGYIVKTAKKLLKNGSEDSLLKLRELSYQDAKEQLIQLPGVGPKVADCILLMSLDKAGAIPVDTHMFQIAARYYLPH----LVGKKSVNSKIYLEIGDYFRDLFGDYAGWAHSVLFSADLK--HLQGMKNKDDIEGK 319
[Close]
BLAST of N-glycosylase/DNA lyase vs. TrEMBL
Match: H2CP63 (8-oxoguanine DNA glycosylase OS=Tigriopus japonicus OX=158387 GN=OGG1 PE=2 SV=1)

HSP 1 Score: 231.491 bits (589), Expect = 8.468e-70
Identity = 130/312 (41.67%), Postives = 181/312 (58.01%), Query Frame = 2 
Query:   35 MSWHLLEFNGDNKVEINLNLTLSCGQAFRWELCGGE---WRCGFNGFIAQLKQEPDYNVY--FYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIE--NLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            MSW L+      + E+ L++ L CGQ+FRW+    +   W       +  L Q+ D+  Y  F    ED   +  FL +YF+ +  L    K W   D  F KIS  F G+R+LRQHPVENLFSFICSSNNNI+RI+ +V  L I FG++ +      + + Y  FPSV+ L+    N+E+ LR LGFGYRA YI K+A  +  NGGE  LL+LR   +++AR  L+ L+G+G KVADCVLL SLD    +P+D HMF++    Y  H        KSVT   Y++I   F  ++   +GWA  ++F++DLK
Sbjct:    8 MSWKLIPCL---RSELRLDIVLKCGQSFRWKSFNDQPDQWIGVLGSRVWLLSQDQDHLKYKTFPKAEEDSGALDAFLADYFQLKVKLQPLYKVWAKEDPVFEKISSKFSGVRMLRQHPVENLFSFICSSNNNIQRISSMVENLCIHFGTEIW----KHEGVSYHTFPSVEQLAKNPMNVEKKLRGLGFGYRAAYIAKSAKQIAENGGEEYLLKLRTLPYQEARDELLKLTGIGPKVADCVLLMSLDQTAAIPVDTHMFQIAANKYLPHLK----GYKSVTDKAYKEIGDHFRSLYGDYAGWAHSVLFSADLK 308
[Close]
BLAST of N-glycosylase/DNA lyase vs. TrEMBL
Match: E9G475 (ENDO3c domain-containing protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_313422 PE=4 SV=1)

HSP 1 Score: 229.565 bits (584), Expect = 4.493e-69
Identity = 126/334 (37.72%), Postives = 200/334 (59.88%), Query Frame = 2 
Query:   74 VEINLNLTLSCGQAFRWELC-GGEWRCGFNGFIAQLKQEP---DYNVYFYS------KNEDFTKIKIF---------LNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPVHFQEKKQISNLKRKIENNLDL 1018
             E++L+++L+CGQ+FRW+    GEW     G++  + Q+    +Y V   S       +    K ++          L +YF+    L    + W L+D  F++++KNF G+R+LRQ PVENLF+FICSSNNNI+RIT +V  L   +G+ Q LT ++   + Y +FP+++ L+ + +E  LR LGFGYRAK+I+++A  +  NGG   L+ LRN S+ +A+  LM L G+G+KVADC+ L SLDH   +P+D H+F++ K  Y  H  Q     KSVT  +Y++I   F  ++ P +GWA  ++F++DL+  H + +   +  KR  E + D+
Sbjct:    8 AELSLDISLNCGQSFRWKKSLTGEWIGVLGGYLWLMTQDETCINYRVVQPSVKIEPASSPSAVKTELLKECIDYEHILKDYFQLNIDLESLYRQWSLADPNFNQVAKNFAGVRMLRQDPVENLFAFICSSNNNIQRITGMVEKLCENYGN-QLLTHED---VAYYSFPALESLAADKVESRLRTLGFGYRAKFIQQSAAKIVENGGRDWLMNLRNLSYPEAKTALMTLPGIGAKVADCICLMSLDHSVAIPVDTHVFQIAKASYVPHLSQ----TKSVTDKVYKEISAHFQSLFGPYAGWAHSVLFSADLR--HLKAEPSPAK-KRSREKSQDV 330
[Close]
BLAST of N-glycosylase/DNA lyase vs. TrEMBL
Match: A0A3N4IQ18 (DNA glycosylase OS=Ascobolus immersus RN42 OX=1160509 GN=BJ508DRAFT_410147 PE=4 SV=1)

HSP 1 Score: 229.18 bits (583), Expect = 2.783e-68
Identity = 121/302 (40.07%), Postives = 173/302 (57.28%), Query Frame = 2 
Query:   77 EINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLKQEPDYNVYFYSKNEDFTKIKI-----------FLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            E+ ++  L CGQ+FRW+  G  W C   G +  L+QEPD+  Y     E F +  +            LN+YF     L    K W   D +FSK +  F GIR+LRQ P ENL SFICSSNNNI RI ++V  L I +G +    D       Y  FP+ + L+++ +EE+LR+LGFGYRAKYI +TA  + N   E  L+ LR + + +A   L+ LSGVG KVADC+ L SLD  E VP+D H+ ++  + Y   F++  + +KS+T  +Y+ +   F  +W P +GWA  ++F +DLK
Sbjct:   13 ELCIDTVLRCGQSFRWKKTGETWSCALKGRVLLLQQEPDHLRY----REIFPEAPVEAQGSGTSTIDLLNDYFNLSTDLKSLYKQWSDRDPHFSKKAITFTGIRMLRQDPWENLISFICSSNNNISRIGQMVGNLCIHYGPRIAEVD----GTVYHDFPAPEKLAVKGVEETLRKLGFGYRAKYIAQTANMVVNELPEGWLMGLREKPYREAHDALLQLSGVGPKVADCICLMSLDKTEAVPVDTHVMQIATRDY--KFNK--IKSKSMTKALYDAVGDHFRELWGPGAGWAHSVLFTADLK 302
[Close]
BLAST of N-glycosylase/DNA lyase vs. TrEMBL
Match: A0A2Z6QAB6 (ENDO3c domain-containing protein OS=Rhizophagus clarus OX=94130 GN=RclHR1_13570010 PE=4 SV=1)

HSP 1 Score: 224.942 bits (572), Expect = 5.934e-67
Identity = 127/316 (40.19%), Postives = 185/316 (58.54%), Query Frame = 2 
Query:   32 SMSWHLLEFNGDNKVEINLNLTLSCGQAFRWELCG-GEWRCGFNGFIAQLKQEP---DYNVYFYSK---NEDFTKIKIFLNNYFRCQE-SLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENN--GGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            S  W  L+ + +   E+ L+ TL CGQ+FRW++ G  EW C F G +  LKQ P   +Y  YF SK     +  K+  FL +YF+    +LSE    W  +D +F+ I++ F GIR+LRQ P+ENL  FICS+NNNI RIT+++  L   +G K +  +  D    Y  FP+++ L+  N+E  LR+LGFGYRAKYI +TA ++  N   G   L  LRN  +++A   L+ LSGVG KVADCV L SL+    +P+D H++++ +K Y      +   + S+T   YE +   F  I+   SGWA  ++F SDL+
Sbjct:    2 STVWRTLKVSAE---ELRLDTTLKCGQSFRWKISGKNEWSCAFKGRLITLKQTPSDIEYRTYFNSKVLSPHELDKLHEFLTDYFQLNTVNLSEYYTKWCKADKHFANIAQKFKGIRILRQDPIENLICFICSTNNNINRITQMIEKLCRRYGDKVYTLNGED----YFDFPTLEKLTSPNVENELRRLGFGYRAKYIVQTAKYICENFPDGNVWLYNLRNLDYKEAHAALLKLSGVGPKVADCVCLMSLNKHNAIPVDTHVWQIAQKKYGFSVKTK-EKSNSLTSRNYEAVGDYFRKIFGEYSGWAHSVLFTSDLR 309
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Cavefish
Match: ogg1 (8-oxoguanine DNA glycosylase [Source:NCBI gene;Acc:103043309])

HSP 1 Score: 192.2 bits (487), Expect = 1.883e-57
Identity = 119/342 (34.80%), Postives = 167/342 (48.83%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRWELCG-GEWRCGFNGFIAQLKQEPD---YNVYFYSKN------------------------------------------EDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHY---ASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLK 949
            + E+ L+LTL CGQ+FRW   G G W     G +  L Q  D   Y+VY    N                                          E   K    L +YF+    L +  + W  +D +FS+ +  F G+R+LRQ PVE LFSFICSSNN+I RI  +V  L  T G+     DD      Y  FP +  L+   +E  LR LGFGYRA++++++A+ + N+ G   L  LR+  +  AR  L  L GVG KVADCV L SLD  E VP+D H++++ K+ Y   A H        K++T  +Y +I   F  +W   +GWA  ++F +DLK
Sbjct:   21 RSELRLDLTLGCGQSFRWRETGEGHWTGVMGGRVWTLTQTEDTLWYHVYSNPGNTALINGQKRKAEVGPQHSEKKLKQVSTVKKEEDELDLDAVSSEQDEKAGTLLRDYFQLDVKLGDLYREWSDADQHFSQTAHIFTGVRMLRQDPVECLFSFICSSNNHISRIQGMVERLCNTLGTPLCKLDDTH----YHDFPPLQALADSKVEACLRDLGFGYRARFLQQSAHLIMNSHGPDWLYTLRSAPYLQARDALRTLPGVGLKVADCVCLMSLDKSEAVPVDTHVWQIAKRDYNCAAGH------GQKTLTDKLYNEIGDFFRKLWGCYAGWAHSVLFCADLK 352
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Cavefish
Match: ogg1 (8-oxoguanine DNA glycosylase [Source:NCBI gene;Acc:103043309])

HSP 1 Score: 183.726 bits (465), Expect = 2.426e-54
Identity = 115/336 (34.23%), Postives = 162/336 (48.21%), Query Frame = 2 
Query:   71 KVEINLNLTLSCGQAFRWELCG-GEWRCGFNGFIAQLKQEPD---YNVYFYSKN------------------------------------------EDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHY---ASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLII 931
            + E+ L+LTL CGQ+FRW   G G W     G +  L Q  D   Y+VY    N                                          E   K    L +YF+    L +  + W  +D +FS+ +  F G+R+LRQ PVE LFSFICSSNN+I RI  +V  L  T G+     DD      Y  FP +  L+   +E  LR LGFGYRA++++++A+ + N+ G   L  LR+  +  AR  L  L GVG KVADCV L SLD  E VP+D H++++ K+ Y   A H        K++T  +Y +I   F  +W   +GWA  ++
Sbjct:   21 RSELRLDLTLGCGQSFRWRETGEGHWTGVMGGRVWTLTQTEDTLWYHVYSNPGNTALINGQKRKAEVGPQHSEKKLKQVSTVKKEEDELDLDAVSSEQDEKAGTLLRDYFQLDVKLGDLYREWSDADQHFSQTAHIFTGVRMLRQDPVECLFSFICSSNNHISRIQGMVERLCNTLGTPLCKLDDTH----YHDFPPLQALADSKVEACLRDLGFGYRARFLQQSAHLIMNSHGPDWLYTLRSAPYLQARDALRTLPGVGLKVADCVCLMSLDKSEAVPVDTHVWQIAKRDYNCAAGH------GQKTLTDKLYNEIGDFFRKLWGCYAGWAHSMV 346
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Yeast
Match: OGG1 (Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance [Source:SGD;Acc:S000004525])

HSP 1 Score: 162.54 bits (410), Expect = 3.771e-47
Identity = 113/330 (34.24%), Postives = 167/330 (50.61%), Query Frame = 2 
Query:   68 NKVEINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLK--QEPDYNVYFYSKNED-----FTKI---------KIFLNNYFRCQESLSEKIKS-WILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLE--------LRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYA-----SHFDQQILNAKSVTPIIYEKIRKVFNVI-------WHPNSGWAQLIIFASDL 946
            NK E+ L   L  GQ+FRW      W    N +   +K  Q+  Y+V    ++E+     F  +         K  L  YFR   SL     + WI SD  F+K+S    GIR+L Q P E L SFICSSNNNI RIT++  +L   FG+     D     + Y +FP+ ++L+    E  LR+LGFGYRAKYI +TA  L N+  E+ +           ++  +ED R+ LM+ +GVG KVADCV L  L     VP+D+H+ ++ K+ Y      +H  +++    +  PI  +KI    + I       W   +GWAQ ++F+ ++
Sbjct:   11 NKSELCLANVLQAGQSFRWI-----WDEKLNQYSTTMKIGQQEKYSVVILRQDEENEILEFVAVGDCGNQDALKTHLMKYFRLDVSLKHLFDNVWIPSDKAFAKLSPQ--GIRILAQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTID----GVAYHSFPTSEELTSRATEAKLRELGFGYRAKYIIETARKLVNDKAEANITSDTTYLQSICKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQISANKNHL-KELRTKYNALPISRKKINLELDHIRLMLFKKWGSYAGWAQGVLFSKEI 328
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Nematostella
Match: EDO37002 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGZ3])

HSP 1 Score: 202.216 bits (513), Expect = 1.411e-62
Identity = 116/315 (36.83%), Postives = 169/315 (53.65%), Query Frame = 2 
Query:   77 EINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPDYNVYFY----------------------------SKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIF 934
            ++ L++ LS GQ+FRW E    EWR    G +  LKQ+ ++  Y                                N+++   +  L +YF+    L +    W  +D  FSK+SK+F GIR LRQ PVENLFSFICSSNNNI RIT ++  +   +G K    D  D    Y +FP+V  L+   +E+ LR +GFGYRAK+I K+A  +   GG+  LL LR QS++DA   L  L G+GSKVADCV L SLD    +P+D H++++  K Y  +    +L  K++T  +Y +I   +  ++   +GWA  + F
Sbjct:   15 QVRLDVVLSAGQSFRWHETSEREWRSVLRGKVWTLKQDAEFLYYTVHDPVPAVTSSIKPCSSEQSSLQGERTSSDDNQNWNDYEAILTDYFQLNIDLQDLYDKWSAADINFSKVSKSFTGIRTLRQEPVENLFSFICSSNNNISRITSMIEKMCSKYGEKVASVDGID----YFSFPTVSSLADPKVEQDLRSMGFGYRAKFINKSAQLIIEYGGQDWLLSLRKQSYQDAHSALCKLPGIGSKVADCVCLMSLDKHSAIPVDTHVWQITAKCYMPN----LLKNKTLTDKLYLQIGDHYRCLFGEYAGWAHSVSF 321
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Nematostella
Match: EDO27821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T872])

HSP 1 Score: 153.68 bits (387), Expect = 5.600e-45
Identity = 89/230 (38.70%), Postives = 131/230 (56.96%), Query Frame = 2 
Query:   29 NSMSWHLLEFNGDNKVEINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPDYNVYFYSKNEDFTKIKIFLNNY-FRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVG 712
            +S++W  +        ++ L++ LS GQ+FRW E    EWR    G +  LKQ+ ++   +Y+ ++    +   +  Y F+    L +  K W  +D  FSK++K+F GIR LRQ PVENLFSFICSSNNNI RIT ++  +   +G K    D  D    Y +FP+V  L+   +E+ LR +GFGYRAK+I K+A  +   GG+  LL LR QS++DA   +     VG
Sbjct:    2 SSVAWRRIPCKAS---QVRLDVVLSAGQSFRWHETSEREWRSVLRGKVWTLKQDAEF--LYYTVHDPVPAVTSSIKPYYFQLNIDLQDLYKKWSAADINFSKVAKSFTGIRTLRQEPVENLFSFICSSNNNIWRITSMIEKMCSKYGEKVASVDGID----YFSFPTVSSLADPKVEQDLRSMGFGYRAKFINKSAQLITEYGGQDWLLSLRKQSYQDAHSGVCCWGCVG 222
[Close]
BLAST of N-glycosylase/DNA lyase vs. Ensembl Medaka
Match: ogg1 (8-oxoguanine DNA glycosylase [Source:NCBI gene;Acc:101169533])

HSP 1 Score: 196.823 bits (499), Expect = 3.451e-59
Identity = 116/338 (34.32%), Postives = 174/338 (51.48%), Query Frame = 2 
Query:   77 EINLNLTLSCGQAFRW-ELCGGEWRCGFNGFIAQLKQEPD---YNVYFYSK----------------------------NEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIFASDLKPVHFQEKKQISNLKR 994
            E+ L+LTL+CGQ+FRW E   G W     G +  L Q  D   Y+VY   K                             +  T     L +YF+    + +  + W  +D +F   +  F G+R+LRQ P E LFSFIC+SNN+I RI  +V  L    G+     D       Y  FP++  L+  ++E  LR LGFGYRA+Y++++A  + ++ G   +  LR   + +AR+ L  L GVG+KVADCV L SLD  E VP+D H++++ K+ Y    D      KS+T  +Y+ I   F  +W P +GW Q ++F +DLK   FQ  K++ ++K+
Sbjct:   24 ELRLDLTLACGQSFRWKETAEGHWTGVMGGRVWTLTQTDDRLWYHVYTNQKKRGGRENRAEEKPEGVPNVEEEAPAVTDEQQSTMEAEMLRDYFQLHVKMEDLCRHWGAADRHFKNTADVFTGVRMLRQDPTECLFSFICTSNNHISRIQGMVERLCQALGAPLCQLDQTP----YHDFPTLSALADSSVEARLRDLGFGYRARYLQQSAKMILDSHGSQWIEGLRRVPYLEAREALRTLPGVGAKVADCVCLMSLDKPEAVPVDTHVWQIAKRDYKYAADN---GQKSLTDKLYKDIGDFFRKLWGPYAGWGQSVLFCADLK--KFQTLKEMGHMKQ 352
[Close]
BLAST of N-glycosylase/DNA lyase vs. Planmine SMEST
Match: SMESG000001427.1 (SMESG000001427.1)

HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0
Identity = 296/300 (98.67%), Postives = 299/300 (99.67%), Query Frame = 2 
Query:   35 MSWHLLEFNGDNKVEINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLKQEPDYNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIF 934
            MSWHLLEFNGDNKVEINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLKQEPDYNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWIL+DNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWL+NNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQL+I 
Sbjct:    1 MSWHLLEFNGDNKVEINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLKQEPDYNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILADNYFSKISKNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLKNNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHMFKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLVIL 300
[Close]
BLAST of N-glycosylase/DNA lyase vs. Planmine SMEST
Match: SMESG000010115.1 (SMESG000010115.1)

HSP 1 Score: 249.98 bits (637), Expect = 2.893e-83
Identity = 123/129 (95.35%), Postives = 124/129 (96.12%), Query Frame = 2 
Query:  350 IRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGGESGLLELRNQSFEDARKFLMNLSGVGSKVADCVL 736
            IRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWL+NN GESGLLELRNQSFEDARKFLMNLSGVGSKV    L
Sbjct:   17 IRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTDDNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLKNNRGESGLLELRNQSFEDARKFLMNLSGVGSKVGSNYL 145
The following BLAST results are available for this feature:
BLAST of N-glycosylase/DNA lyase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
OGG16.895e-6337.508-oxoguanine DNA glycosylase [Source:HGNC Symbol;A... [more]
OGG12.101e-5937.258-oxoguanine DNA glycosylase [Source:HGNC Symbol;A... [more]
OGG13.583e-5937.508-oxoguanine DNA glycosylase [Source:HGNC Symbol;A... [more]
OGG18.464e-5937.258-oxoguanine DNA glycosylase [Source:HGNC Symbol;A... [more]
OGG13.381e-5837.508-oxoguanine DNA glycosylase [Source:HGNC Symbol;A... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Ogg12.721e-5537.46gene:FBgn0027864 transcript:FBtr0071223[more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ogg18.155e-5734.828-oxoguanine DNA glycosylase [Source:ZFIN;Acc:ZDB-... [more]
ogg14.782e-3534.488-oxoguanine DNA glycosylase [Source:ZFIN;Acc:ZDB-... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
hs3st3a15.932e-5338.71heparan sulfate-glucosamine 3-sulfotransferase 3A1... [more]
hs3st3a16.260e-5338.71heparan sulfate-glucosamine 3-sulfotransferase 3A1... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Ogg13.933e-6436.548-oxoguanine DNA-glycosylase 1 [Source:MGI Symbol;... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O08760|OGG1_MOUSE2.751e-6336.54N-glycosylase/DNA lyase OS=Mus musculus OX=10090 G... [more]
sp|O15527|OGG1_HUMAN3.311e-6237.50N-glycosylase/DNA lyase OS=Homo sapiens OX=9606 GN... [more]
sp|O70249|OGG1_RAT7.095e-6136.54N-glycosylase/DNA lyase OS=Rattus norvegicus OX=10... [more]
sp|Q9V3I8|OGG1_DROME2.728e-5437.46N-glycosylase/DNA lyase OS=Drosophila melanogaster... [more]
sp|P53397|OGG1_YEAST2.618e-4534.24N-glycosylase/DNA lyase OS=Saccharomyces cerevisia... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0K2SVA81.256e-7043.08ENDO3c domain-containing protein OS=Lepeophtheirus... [more]
H2CP638.468e-7041.678-oxoguanine DNA glycosylase OS=Tigriopus japonicu... [more]
E9G4754.493e-6937.72ENDO3c domain-containing protein OS=Daphnia pulex ... [more]
A0A3N4IQ182.783e-6840.07DNA glycosylase OS=Ascobolus immersus RN42 OX=1160... [more]
A0A2Z6QAB65.934e-6740.19ENDO3c domain-containing protein OS=Rhizophagus cl... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ogg11.883e-5734.808-oxoguanine DNA glycosylase [Source:NCBI gene;Acc... [more]
ogg12.426e-5434.238-oxoguanine DNA glycosylase [Source:NCBI gene;Acc... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
OGG13.771e-4734.24Nuclear and mitochondrial glycosylase/lyase; speci... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO370021.411e-6236.83Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO278215.600e-4538.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ogg13.451e-5934.328-oxoguanine DNA glycosylase [Source:NCBI gene;Acc... [more]
back to top
BLAST of N-glycosylase/DNA lyase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000001427.10.000e+098.67SMESG000001427.1[more]
SMESG000010115.12.893e-8395.35SMESG000010115.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033852 ID=SMED30033852|Name=N-glycosylase/DNA lyase|organism=Schmidtea mediterranea sexual|type=transcript|length=1073bp
CTTTTATAACCTTGAATATTTTATATAAAATTCAATGTCTTGGCATTTAT
TGGAATTTAACGGAGATAATAAAGTTGAGATAAATTTAAACTTAACTTTG
AGTTGTGGTCAAGCCTTTAGATGGGAGCTGTGTGGTGGTGAATGGAGATG
TGGATTTAATGGATTTATTGCACAATTAAAACAAGAACCAGATTATAATG
TATACTTTTATTCGAAAAATGAGGATTTTACAAAAATTAAAATATTTCTT
AACAATTACTTTCGATGTCAAGAAAGTTTATCAGAAAAGATAAAATCTTG
GATTTTATCAGACAACTACTTTTCAAAAATTTCTAAAAACTTTATGGGGA
TCAGATTATTACGTCAGCATCCCGTCGAAAATTTGTTTTCTTTTATTTGT
TCATCCAACAACAATATAAAAAGAATTACAAAATTAGTATGTGCTTTAGC
AATTACTTTCGGATCAAAACAGTTTTTGACTGACGATAATGATAAATCCA
TTTGCTATCCAGCTTTTCCATCGGTAGATGATTTATCCATTGAAAATCTC
GAAGAATCTCTTCGACAATTGGGGTTTGGTTATCGTGCAAAATATATCAA
AAAAACTGCTTATTGGCTTGAAAATAATGGAGGGGAAAGTGGATTACTTG
AATTACGAAACCAGTCATTCGAAGACGCTAGAAAGTTTCTAATGAATCTT
TCAGGGGTTGGATCAAAGGTTGCGGATTGTGTTCTTCTTTGCTCTCTTGA
CCATCTTGAAACCGTTCCAATCGATATCCACATGTTTAAAGTAATGAAAA
AGCACTATGCTTCACATTTCGATCAACAAATACTTAATGCAAAATCTGTT
ACCCCGATTATTTACGAAAAAATTAGAAAAGTTTTCAACGTAATCTGGCA
TCCAAACTCTGGATGGGCACAATTGATAATATTTGCCTCAGATTTGAAGC
CCGTGCATTTCCAAGAGAAAAAACAAATTTCAAATTTAAAGAGAAAAATC
GAAAATAACTTAGATTTGTGACTTGCATTTATAACAAAAAATTTCGCATT
TTACGAAAATATGTTCTGCAAAT
back to top

protein sequence of SMED30033852-orf-1

>SMED30033852-orf-1 ID=SMED30033852-orf-1|Name=SMED30033852-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=329bp
MSWHLLEFNGDNKVEINLNLTLSCGQAFRWELCGGEWRCGFNGFIAQLKQ
EPDYNVYFYSKNEDFTKIKIFLNNYFRCQESLSEKIKSWILSDNYFSKIS
KNFMGIRLLRQHPVENLFSFICSSNNNIKRITKLVCALAITFGSKQFLTD
DNDKSICYPAFPSVDDLSIENLEESLRQLGFGYRAKYIKKTAYWLENNGG
ESGLLELRNQSFEDARKFLMNLSGVGSKVADCVLLCSLDHLETVPIDIHM
FKVMKKHYASHFDQQILNAKSVTPIIYEKIRKVFNVIWHPNSGWAQLIIF
ASDLKPVHFQEKKQISNLKRKIENNLDL*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: molecular function
TermDefinition
GO:0003684damaged DNA binding
GO:0008534oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0003824catalytic activity
GO:0016829lyase activity
Vocabulary: biological process
TermDefinition
GO:0006281DNA repair
GO:0006284base-excision repair
GO:0006289nucleotide-excision repair
Vocabulary: INTERPRO
TermDefinition
IPR003265HhH-GPD_domain
IPR023170HTH_base_excis_C
IPR012904OGG_N
IPR011257DNA_glycosylase
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003265HhH-GPD domainSMARTSM00478endo3endcoord: 122..297
e-value: 1.2E-10
score: 51.4
IPR003265HhH-GPD domainPFAMPF00730HhH-GPDcoord: 119..263
e-value: 1.1E-10
score: 41.9
IPR003265HhH-GPD domainCDDcd00056ENDO3ccoord: 115..300
e-value: 3.92227E-21
score: 86.1414
IPR0129048-oxoguanine DNA glycosylase, N-terminalPFAMPF07934OGG_Ncoord: 13..117
e-value: 6.8E-19
score: 68.1
NoneNo IPR availableGENE3DG3DSA:1.10.340.30coord: 112..240
e-value: 4.0E-65
score: 221.0
NoneNo IPR availableGENE3DG3DSA:3.30.310.40coord: 2..76
e-value: 2.0E-8
score: 35.5
NoneNo IPR availablePANTHERPTHR102428-OXOGUANINE DNA GLYCOSYLASEcoord: 13..313
NoneNo IPR availablePANTHERPTHR10242:SF2N-GLYCOSYLASE/DNA LYASEcoord: 13..313
NoneNo IPR availableSUPERFAMILYSSF55945TATA-box binding protein-likecoord: 12..111
IPR023170Helix-turn-helix, base-excision DNA repair, C-terminalGENE3DG3DSA:1.10.1670.10coord: 86..304
e-value: 4.0E-65
score: 221.0
IPR011257DNA glycosylaseSUPERFAMILYSSF48150DNA-glycosylasecoord: 113..303