DLH domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033810 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of DLH domain-containing protein vs. Ensembl Human
Match: CMBL (carboxymethylenebutenolidase homolog [Source:HGNC Symbol;Acc:HGNC:25090]) HSP 1 Score: 77.0258 bits (188), Expect = 8.354e-16 Identity = 60/234 (25.64%), Postives = 108/234 (46.15%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDC----VFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y G E+ + +K Y T S G +I++ DIFG+ + TR AD+++ + + ++PDFF G+ PW P + F +WL + I ++++ +L + K GI+GFCWGG + + + GVSV+G + ++K P +F+ A +D + + L ++ + + C F HGF + + K I + + +LNK+ Sbjct: 17 EYGGLGREVQ-VEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTRYIADMISGNGYTTIVPDFFVGQEPWD----PSGDWSIFPEWLKTRNAQKI-DREISAILKYLKQQCHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDVVIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEWLNKY 244
BLAST of DLH domain-containing protein vs. Ensembl Zebrafish
Match: cmbl (carboxymethylenebutenolidase homolog (Pseudomonas) [Source:ZFIN;Acc:ZDB-GENE-071004-21]) HSP 1 Score: 94.7449 bits (234), Expect = 1.590e-22 Identity = 72/234 (30.77%), Postives = 113/234 (48.29%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGS-GNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGV---ENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y G E+ + +K Y ++ +I++ DI+G+ + TR AD+L+ + + + PDFF GK PWS P + F +WL D T ++K++ V +L + G++GFCWGG + Y A Q + GVSV+G D+K P +F+ A +D LD V E LK K D F K HGF + + + + K I + +N+LNK+ Sbjct: 17 EYGGVGEEVQ-IEHIKAYVVKPPASEKAIIVIQDIYGWQLPNTRYMADMLSSNGYIAICPDFFVGKEPWS----PSHDWSTFPQWLEDKKP-TEIKKEVDVVLKYLKDQCGVKRIGVVGFCWGGVSTHYIALQYEEIKAGVSVYGIVREREDRFDLKSPTLFIFAENDAVIPLDQVTTLETRLKEKCTA-DFQVKIFPKQTHGFVHRKREDINPDDKPYIEEARKDMINWLNKY 243
BLAST of DLH domain-containing protein vs. Ensembl Xenopus
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:394496]) HSP 1 Score: 81.6481 bits (200), Expect = 1.689e-17 Identity = 68/235 (28.94%), Postives = 107/235 (45.53%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD-----PSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y +KG E+ + +K Y S +I+V DIFG+ + TR ADLL H + + PDFF G+ PW SN + F +WL + T VEK++ V +L + K G++GFCWGG ++ + + GVS +G ++ P +F+ A D + +E LK S D F K HGF + + + K I + + +L+K+ Sbjct: 17 EYGAKGQEVQ-IEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQEPWKPSN----DRSTFTEWLQTRQA-TKVEKEINVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEMDHVIPLEQVSLLEEKLKVHS-KVDFQVKVFPKQTHGFVHRKNEDINPEDKPFIEEARKNMLEWLHKY 244
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824]) HSP 1 Score: 79.7221 bits (195), Expect = 5.563e-17 Identity = 63/236 (26.69%), Postives = 108/236 (45.76%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFA 849 Y G E+ + +K Y T S G +I+V DIFG+ + TR AD++A + + ++PDFF G+ PW P + F WL + V +++ +L + K GI+GFCWGG + + T + GVSV+G V ++K P +F+ A +D + + ++ + + C+ + F HGF + + K I + + +LNK+ Sbjct: 17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKYV 245
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824]) HSP 1 Score: 77.411 bits (189), Expect = 2.477e-16 Identity = 58/206 (28.16%), Postives = 97/206 (47.09%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFA 759 Y G E+ + +K Y T S G +I+V DIFG+ + TR AD++A + + ++PDFF G+ PW P + F WL + V +++ +L + K GI+GFCWGG + + T + GVSV+G V ++K P +F+ A +D + + ++ + + C+ + F HGF Sbjct: 17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFV 215
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824]) HSP 1 Score: 56.6102 bits (135), Expect = 2.566e-9 Identity = 50/170 (29.41%), Postives = 77/170 (45.29%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD 663 Y G E+ + +K Y T S G +I+V DIFG+ + TR ++PDFF G+ PW P + F WL + V +++ +L + K GI+GFCWGG + + T + GVSV+G V ++K P +F+ A +D Sbjct: 17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTR------------TIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAEND 167
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824]) HSP 1 Score: 47.7506 bits (112), Expect = 1.278e-6 Identity = 30/87 (34.48%), Postives = 45/87 (51.72%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWL 420 Y G E+ + +K Y T S G +I+V DIFG+ + TR AD++A + + ++PDFF G+ PW P + F WL Sbjct: 17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWL 98
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|O14359|YB4E_SCHPO (Uncharacterized AIM2 family protein C30D10.14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC30D10.14 PE=3 SV=1) HSP 1 Score: 85.1149 bits (209), Expect = 4.121e-18 Identity = 70/232 (30.17%), Postives = 99/232 (42.67%), Query Frame = 1 Query: 139 CCTSGQ---PKSDSYVSKGTEINTLSDLKLYHTGS-GNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIV-----EKDLIVARDFLSKAGTTNKPGILGFCWGGK-MSAYACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPS--LDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKE 798 CC + + + SY KG EI L Y GS N LI DIFG + +Q + AD LA+ F V +PDF GKP ++ PPK ++ K ND S I K V + G G GFCWG K + Y DF S H + ++ P++FL + D+ + + E K+ F F M HG+ AAR D ++ ++ Sbjct: 4 CCPTSRGAAASNKSYTFKGKEIENFGGLTTYVVGSTSNTRVLIGFMDIFGLS-DQIKEGADKLADDGFTVYLPDFLEGKPLPVTALPPKTPED-QKLCNDFFSTRISPNLHWPKLAKVVEAVRANHGPNVTIGTYGFCWGAKVLVTYPATIDFVGIA-SCHPSFPDSADAANVHCPVLFLCSKDEDAKIIKEWEEAFKTNPAYAKSSFETFSDMFHGWMAARADLSNPEQRK 232
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7TP52|CMBL_RAT (Carboxymethylenebutenolidase homolog OS=Rattus norvegicus OX=10116 GN=Cmbl PE=2 SV=1) HSP 1 Score: 82.0333 bits (201), Expect = 6.519e-17 Identity = 65/233 (27.90%), Postives = 109/233 (46.78%), Query Frame = 1 Query: 172 YVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQT-DFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y G E+ + +K Y T S G +I+V DIFG+ ++ TR AD++A + + ++PDFF G+ PW P + F +WL + I + V R +L + K GI+GFCWGG + + T GVSV+G V ++K P +F+ A +D + + + + + + C+ + F HGF + + K I + + +LNK+ Sbjct: 18 YGGMGQEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLSNTRYMADMIAGNGYTTIVPDFFVGQEPWD----PAGDWSTFPEWLKSRNARKINREVDAVLR-YLKQQCHAQKIGIVGFCWGGIVVHHVMTTYPEVRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDAVIPLEQVSILIQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKY 244
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6P7K0|CMBL_XENTR (Carboxymethylenebutenolidase homolog OS=Xenopus tropicalis OX=8364 GN=cmbl PE=2 SV=1) HSP 1 Score: 81.6481 bits (200), Expect = 8.946e-17 Identity = 68/235 (28.94%), Postives = 107/235 (45.53%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD-----PSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y +KG E+ + +K Y S +I+V DIFG+ + TR ADLL H + + PDFF G+ PW SN + F +WL + T VEK++ V +L + K G++GFCWGG ++ + + GVS +G ++ P +F+ A D + +E LK S D F K HGF + + + K I + + +L+K+ Sbjct: 17 EYGAKGQEVQ-IEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQEPWKPSN----DRSTFTEWLQTRQA-TKVEKEINVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEMDHVIPLEQVSLLEEKLKVHS-KVDFQVKVFPKQTHGFVHRKNEDINPEDKPFIEEARKNMLEWLHKY 244
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8R1G2|CMBL_MOUSE (Carboxymethylenebutenolidase homolog OS=Mus musculus OX=10090 GN=Cmbl PE=1 SV=1) HSP 1 Score: 79.7221 bits (195), Expect = 3.892e-16 Identity = 63/236 (26.69%), Postives = 108/236 (45.76%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFA 849 Y G E+ + +K Y T S G +I+V DIFG+ + TR AD++A + + ++PDFF G+ PW P + F WL + V +++ +L + K GI+GFCWGG + + T + GVSV+G V ++K P +F+ A +D + + ++ + + C+ + F HGF + + K I + + +LNK+ Sbjct: 17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKYV 245
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5XH09|CMBL_XENLA (Carboxymethylenebutenolidase homolog OS=Xenopus laevis OX=8355 GN=cmbl PE=2 SV=1) HSP 1 Score: 77.7962 bits (190), Expect = 2.183e-15 Identity = 63/211 (29.86%), Postives = 97/211 (45.97%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNN-DEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD-----PSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGD 774 Y +KG EI + +K Y S +I+V DIFG+ + TR ADLL H + + PDFF G+ ++ P N+ F +WL + T VEK++ V +L + K G++GFCWGG ++ + + GVS +G ++ P +F+ A D + +E LK S D F K HGF + + Sbjct: 17 EYGAKGQEIQ-IEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQ----ESWKPSNDWSTFTEWLQTRQA-TKVEKEMNVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEIDHVIPLEQVSLLEQKLKVHS-KVDFQIKVFPKQTHGFVHRKKE 220
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A5J4NS28 (DLH domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0015288 PE=4 SV=1) HSP 1 Score: 248.054 bits (632), Expect = 2.904e-77 Identity = 124/267 (46.44%), Postives = 166/267 (62.17%), Query Frame = 1 Query: 109 SNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLY----------HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHS-FNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG--TTNKPGILGFCWGGKMSAYACQTDF--------YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 S+ME++GIKVCCTSG P + K T + T++ L T NK+ ++LVYDIFGF++ QTRRFADLLAE + V+MPDFFRG+PW L NFPPK+ F+ W+ AG + I+ +DL AR++L G T GI+GFCWGGK + AC +T GVS+HGA V VPM+F+PAGDDP++D ++ +L K G C +HRFD HGFAAARGDWN +T+++I K ++L+ F NKF Sbjct: 52 SSMEEQGIKVCCTSGTPTATGGCEKYTPLGTVACLSTSGPRGYLAMPSATQVTNKSAILLVYDIFGFDIVQTRRFADLLAEKTRMRVLMPDFFRGQPWLLQNFPPKDRSHFINWVEQAGRWDIISEDLKCAREYLLTNGLDATASFGIIGFCWGGKQAIRACSGQSHARHLGFSFTAGVSLHGAFFGPDDVEHATVPMLFMPAGDDPAIDPLKAVLDKKPFGHQCAYHRFDTETHGFAAARGDWNIPHTRQAIEKALTLTAEFFNKF 318
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A4S2LFZ4 (DLH domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009126 PE=4 SV=1) HSP 1 Score: 241.891 bits (616), Expect = 3.107e-75 Identity = 123/266 (46.24%), Postives = 164/266 (61.65%), Query Frame = 1 Query: 109 SNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDL-----KLYHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG--TTNKPGILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843 S+M++ GIKVCC+SG P + + + L L Y+T N + LI+VYDIFG ++ QTRRFADLLAE + VVMPDFFRG+PW L NFPPK+ EF+KW+ AGS+ +V DL A +FL G ++ GI+GFCWGGK + AC D + GVS+HGA + D+ VPM+F+PAGDDP + ++ +L K G C +HRFD HGFAAARGDWN +T+E+I+K + L+ NF NK Sbjct: 27 SSMKESGIKVCCSSGTPSATGGCGDYSPVGKLVQLTASGPAAYYTRPKEGPLCNSSALIVVYDIFGIDILQTRRFADLLAERTHRRVVMPDFFRGRPWLLKNFPPKDGGEFVKWVETAGSWDVVSADLKSAHEFLLADGLNSSAPLGIIGFCWGGKQAVRACSGDSHARELGFKFLAGVSLHGAFLGPEDAEDLTVPMLFMPAGDDPDVGPIKVILDKKPFGAQCAYHRFDSETHGFAAARGDWNVPHTREAIMKALDLTANFFNK 292
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A1S8WYI4 (Carboxymethylenebutenolidase OS=Opisthorchis viverrini OX=6198 GN=X801_04659 PE=4 SV=1) HSP 1 Score: 236.113 bits (601), Expect = 2.796e-73 Identity = 122/267 (45.69%), Postives = 162/267 (60.67%), Query Frame = 1 Query: 106 FSNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKL-----YHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG-TTNKP-GILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843 S+M++ GIKVCC+SG P + + + L L Y+T + + LI++YDIFG ++ QTRRF DLLAE + VVMPD FRG PW L NFPPKN EF+KW+ AGS+ IV DL A +FL G +++ P GILGFCWGGK + AC D + GVS+HGA + + VPM+F+PAGDDP + ++ +L K G C +HRFD HGFAAARGDWN +T+E+I+K + L+V F NK Sbjct: 1 MSSMKESGIKVCCSSGTPSATGGCGDYSPVGKLVQLAAPGPTAYYTQPKEGPLCSNSALIVIYDIFGIDILQTRRFVDLLAEKTHRRVVMPDVFRGHPWLLKNFPPKNGGEFVKWVETAGSWEIVSADLKSAHEFLLADGLSSSAPLGILGFCWGGKQAIRACSGDSHASKLGFKFLAGVSLHGAFLGPEDAKHVTVPMLFMPAGDDPDIGPIKEILDKKPFGTQCAYHRFDSETHGFAAARGDWNVPHTREAIMKALDLAVEFFNK 267
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A074ZZR4 (DLH domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_01045 PE=4 SV=1) HSP 1 Score: 234.572 bits (597), Expect = 1.321e-72 Identity = 121/267 (45.32%), Postives = 161/267 (60.30%), Query Frame = 1 Query: 106 FSNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKL-----YHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG-TTNKP-GILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843 S+M++ GIKVCC+SG P + + + L L Y+ + + LI++YDIFG ++ QTRRF DLLAE + VVMPD FRG PW L NFPPKN EF+KW+ AGS+ IV DL A +FL G +++ P GILGFCWGGK + AC D + GVS+HGA + + VPM+F+PAGDDP + ++ +L K G C +HRFD HGFAAARGDWN +T+E+I+K + L+V F NK Sbjct: 1 MSSMKESGIKVCCSSGTPSATGGCGDYSPVGKLVQLAAPGPTAYYAQPKEGPLCSNSALIVIYDIFGIDILQTRRFVDLLAEKTHRRVVMPDVFRGHPWLLKNFPPKNGGEFVKWVETAGSWEIVSADLKSAHEFLLADGLSSSAPLGILGFCWGGKQAIRACSGDSHASKLGFKFLAGVSLHGAFLGPEDAKHVTVPMLFMPAGDDPDIGPIKEILDKKPFGTQCAYHRFDSETHGFAAARGDWNVPHTREAIMKALDLAVEFFNK 267
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A419Q1Y0 (Carboxymethylenebutenolidase-like protein OS=Clonorchis sinensis OX=79923 GN=CMBL PE=4 SV=1) HSP 1 Score: 236.498 bits (602), Expect = 8.032e-72 Identity = 123/268 (45.90%), Postives = 163/268 (60.82%), Query Frame = 1 Query: 106 FSNMEKEGIKVCCTSGQPKSD------SYVSKGTEINTLSDLKLYHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG--TTNKPGILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843 S M+K GI+VCC SG+P + S V K ++ T S Y+T N + LI++YDIFG ++ QTRRFADLLAE + VVMPD FRG+PW L NFPPK+ EF+KW+ AGS+ +V DL A +FL G ++ GILGFCWGGK + AC D Y GVS+HGA + + VPM+F+PAGDDP + ++ +L K G C +HRFD HGFAAARGDWN +T+++I+K + L+ F NK Sbjct: 125 MSPMKKHGIRVCCRSGRPSATGGCGNYSPVGKVVQL-TRSGPAAYYTRPKRGRLLNSSALIVIYDIFGIDILQTRRFADLLAERTHRRVVMPDVFRGRPWLLKNFPPKDGGEFIKWVETAGSWDVVSADLKSAHEFLLADGLNSSAPLGILGFCWGGKQAIQACSGDSYARKLGFKFLAGVSLHGAFLGPEDAKHVTVPMLFMPAGDDPDIGPIKVILDKKPFGAQCAYHRFDSETHGFAAARGDWNVSHTRKAIMKALDLTAEFFNK 391
BLAST of DLH domain-containing protein vs. Ensembl Cavefish
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:103047512]) HSP 1 Score: 90.5077 bits (223), Expect = 5.859e-21 Identity = 68/235 (28.94%), Postives = 113/235 (48.09%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP-----SLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y S G E+ + +K Y + + +I++ DIFG+ + TR AD++A + + + PDFF GK PWS P + F +WL D T + K++ V +L + + + G++GFCWGG + Y + Q GVSV+G + ++K P +F+ A +D + +E LK K D F HGF + + +E + I + +N+LNK+ Sbjct: 17 EYGSLGEEVQ-IDHIKAYVVKPKAPTEKAIIVIQDIFGWQLPNTRYMADMVASNGYIAICPDFFVGKQPWS----PTDDWATFQQWLEDKNP-TKINKEVDVVLKYLKEKCGSKRIGVVGFCWGGVATHYISLQYPEIKAGVSVYGIVREKEDRYELKSPTLFIFAENDAVIPLEQVTTLEANLKDKC-KVDFQVKIFPDQTHGFVHRKREDINEADRRYIQEARGDLINWLNKY 244
BLAST of DLH domain-containing protein vs. Ensembl Sea Lamprey
Match: cmbl (carboxymethylenebutenolidase homolog (Pseudomonas) [Source:ZFIN;Acc:ZDB-GENE-071004-21]) HSP 1 Score: 90.8929 bits (224), Expect = 9.616e-22 Identity = 68/238 (28.57%), Postives = 113/238 (47.48%), Query Frame = 1 Query: 172 YVSKGTEINT------LSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF-YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGK---DCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y +G E+ LS + G + GLI++ DI+G+ + TR AD LA + ++PDFF GK PWS P + F +WL D + T + ++ A D+L K + G+LGFCWGG + T+ GVS +G E +K P++++ +DP LD V+ +L+ + + + D F HGF + + ++ I + + + +LNK+ Sbjct: 18 YSGQGQEVRAGHVDSYLSAAQPGANGEASVRGLIIIQDIYGWKLPNTRFIADWLAGQGYTCIVPDFFLGKEPWS----PSHDWSTFQEWLKDKQA-TNIGTEIDAAMDYLKKECGVQRIGVLGFCWGGLAVHHLLLTNSELQAGVSCYGIIKIEESRYALKNPVLYIFGENDPLIPLDTVQ-LLEKRLVAECQVDVQVKVFPGQTHGFVHRKHEDISPADEQHIKEARANLLAWLNKY 249
BLAST of DLH domain-containing protein vs. Ensembl Sea Lamprey
Match: cmbl (carboxymethylenebutenolidase homolog (Pseudomonas) [Source:ZFIN;Acc:ZDB-GENE-071004-21]) HSP 1 Score: 91.2781 bits (225), Expect = 9.619e-22 Identity = 77/285 (27.02%), Postives = 124/285 (43.51%), Query Frame = 1 Query: 31 KTKLLTIIMVTNLFVKNRNFNLIRLFSNMEKEGIKVCCTSGQPKSDSYVSKGTEINT------LSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF-YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGK---DCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 K K +FV + N M E C G Y +G E+ LS + G + GLI++ DI+G+ + TR AD LA + ++PDFF GK PWS P + F +WL D + T + ++ A D+L K + G+LGFCWGG + T+ GVS +G E +K P++++ +DP LD V+ +L+ + + + D F HGF + + ++ I + + + +LNK+ Sbjct: 1 KQKFPPPPRGPPVFVNEHSENSQGRGEKMANEAKPCPCELGDVMP--YSGQGQEVRAGHVDSYLSAAQPGANGEASVRGLIIIQDIYGWKLPNTRFIADWLAGQGYTCIVPDFFLGKEPWS----PSHDWSTFQEWLKDKQA-TNIGTEIDAAMDYLKKECGVQRIGVLGFCWGGLAVHHLLLTNSELQAGVSCYGIIKIEESRYALKNPVLYIFGENDPLIPLDTVQ-LLEKRLVAECQVDVQVKVFPGQTHGFVHRKHEDISPADEQHIKEARANLLAWLNKY 277
BLAST of DLH domain-containing protein vs. Ensembl Medaka
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:101171616]) HSP 1 Score: 90.1225 bits (222), Expect = 8.060e-21 Identity = 74/235 (31.49%), Postives = 111/235 (47.23%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGKDCVFHR---FDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y G E+ + +K Y S +I+++DIFG+ + TR A++LA + V PDFF GK PWS P + +F +WL D TI K++ ++L + + G +GFCWGG + Y A Q GVSV+G +K P +F+ A D LD V N L++K K V H+ F HGF + + + K I + +N+LNK+ Sbjct: 17 EYGGLGQEVQ-MEHIKAYVVKPTSPKDKAVIVIHDIFGWQLPNTRYMAEMLAADGYIAVCPDFFVGKEPWS----PAGDWSKFQEWLQDKKPTTI-NKEVDAVLNYLKEQCGAKRIGTVGFCWGGVATHYIALQYPEVKAGVSVYGIVREREDRYALKSPTLFIFAEVDQVIPLDQV-NALEAKLKEKCTVEHQVKIFPGQTHGFVHRKREDINPADKPYIQEARKDMLNWLNKY 244
BLAST of DLH domain-containing protein vs. Ensembl Medaka
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:101171616]) HSP 1 Score: 90.1225 bits (222), Expect = 8.060e-21 Identity = 74/235 (31.49%), Postives = 111/235 (47.23%), Query Frame = 1 Query: 169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGKDCVFHR---FDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846 Y G E+ + +K Y S +I+++DIFG+ + TR A++LA + V PDFF GK PWS P + +F +WL D TI K++ ++L + + G +GFCWGG + Y A Q GVSV+G +K P +F+ A D LD V N L++K K V H+ F HGF + + + K I + +N+LNK+ Sbjct: 17 EYGGLGQEVQ-MEHIKAYVVKPTSPKDKAVIVIHDIFGWQLPNTRYMAEMLAADGYIAVCPDFFVGKEPWS----PAGDWSKFQEWLQDKKPTTI-NKEVDAVLNYLKEQCGAKRIGTVGFCWGGVATHYIALQYPEVKAGVSVYGIVREREDRYALKSPTLFIFAEVDQVIPLDQV-NALEAKLKEKCTVEHQVKIFPGQTHGFVHRKREDINPADKPYIQEARKDMLNWLNKY 244
BLAST of DLH domain-containing protein vs. Planmine SMEST
Match: SMESG000077560.1 (SMESG000077560.1) HSP 1 Score: 509.605 bits (1311), Expect = 0.000e+0 Identity = 245/246 (99.59%), Postives = 245/246 (99.59%), Query Frame = 1 Query: 115 MEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFAK 852 MEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDFY CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFAK Sbjct: 1 MEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDFYRCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFAK 246 The following BLAST results are available for this feature:
BLAST of DLH domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of DLH domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of DLH domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of DLH domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of DLH domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of DLH domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of DLH domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of DLH domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of DLH domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of DLH domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of DLH domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of DLH domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033810 ID=SMED30033810|Name=DLH domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=921bpback to top protein sequence of SMED30033810-orf-1 >SMED30033810-orf-1 ID=SMED30033810-orf-1|Name=SMED30033810-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=267bp MVTNLFVKNRNFNLIRLFSNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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