DLH domain-containing protein

Overview
NameDLH domain-containing protein
Smed IDSMED30033810
Length (bp)921
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DLH domain-containing protein (SMED30033810) t-SNE clustered cells

Violin plots show distribution of expression levels for DLH domain-containing protein (SMED30033810) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DLH domain-containing protein (SMED30033810) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DLH domain-containing protein (SMED30033810) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30033810

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30033810SMESG000077560.1 dd_Smed_v4_2062_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30033810SMESG000077560.1 dd_Smed_v4_2062_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30033810SMESG000077560.1 dd_Smed_v4_2062_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30033810SMESG000077560.1 dd_Smed_v4_2062_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30033810SMESG000077560.1 Contig18878newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30033810SMESG000077560.1 Contig18878uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
reproductive organSMED30033810SMESG000077560.1 Contig18878newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30033810SMESG000077560.1 Contig18878uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Human
Match: CMBL (carboxymethylenebutenolidase homolog [Source:HGNC Symbol;Acc:HGNC:25090])

HSP 1 Score: 77.0258 bits (188), Expect = 8.354e-16
Identity = 60/234 (25.64%), Postives = 108/234 (46.15%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDC----VFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y   G E+  +  +K Y T S    G  +I++ DIFG+ +  TR  AD+++ + +  ++PDFF G+ PW     P  +   F +WL    +  I ++++     +L +     K GI+GFCWGG    +   +   +  GVSV+G       + ++K P +F+ A +D  +   +  L ++ + + C        F    HGF   + +      K  I +     + +LNK+
Sbjct:   17 EYGGLGREVQ-VEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTRYIADMISGNGYTTIVPDFFVGQEPWD----PSGDWSIFPEWLKTRNAQKI-DREISAILKYLKQQCHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDVVIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEWLNKY 244
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Zebrafish
Match: cmbl (carboxymethylenebutenolidase homolog (Pseudomonas) [Source:ZFIN;Acc:ZDB-GENE-071004-21])

HSP 1 Score: 94.7449 bits (234), Expect = 1.590e-22
Identity = 72/234 (30.77%), Postives = 113/234 (48.29%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGS-GNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGV---ENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y   G E+  +  +K Y      ++  +I++ DI+G+ +  TR  AD+L+ + +  + PDFF GK PWS    P  +   F +WL D    T ++K++ V   +L       + G++GFCWGG  + Y A Q +    GVSV+G         D+K P +F+ A +D    LD V   E  LK K    D     F K  HGF   + +  + + K  I +     +N+LNK+
Sbjct:   17 EYGGVGEEVQ-IEHIKAYVVKPPASEKAIIVIQDIYGWQLPNTRYMADMLSSNGYIAICPDFFVGKEPWS----PSHDWSTFPQWLEDKKP-TEIKKEVDVVLKYLKDQCGVKRIGVVGFCWGGVSTHYIALQYEEIKAGVSVYGIVREREDRFDLKSPTLFIFAENDAVIPLDQVTTLETRLKEKCTA-DFQVKIFPKQTHGFVHRKREDINPDDKPYIEEARKDMINWLNKY 243
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Xenopus
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:394496])

HSP 1 Score: 81.6481 bits (200), Expect = 1.689e-17
Identity = 68/235 (28.94%), Postives = 107/235 (45.53%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD-----PSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y +KG E+  +  +K Y     S     +I+V DIFG+ +  TR  ADLL  H +  + PDFF G+ PW  SN    +   F +WL    + T VEK++ V   +L +     K G++GFCWGG ++ +   +      GVS +G         ++  P +F+ A  D       +  +E  LK  S   D     F K  HGF   + +  +   K  I +     + +L+K+
Sbjct:   17 EYGAKGQEVQ-IEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQEPWKPSN----DRSTFTEWLQTRQA-TKVEKEINVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEMDHVIPLEQVSLLEEKLKVHS-KVDFQVKVFPKQTHGFVHRKNEDINPEDKPFIEEARKNMLEWLHKY 244
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824])

HSP 1 Score: 79.7221 bits (195), Expect = 5.563e-17
Identity = 63/236 (26.69%), Postives = 108/236 (45.76%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFA 849
             Y   G E+  +  +K Y T S    G  +I+V DIFG+ +  TR  AD++A + +  ++PDFF G+ PW     P  +   F  WL    +   V +++     +L +     K GI+GFCWGG +  +   T +     GVSV+G       V ++K P +F+ A +D  +   +    ++ + + C+ +     F    HGF   + +      K  I +     + +LNK+ 
Sbjct:   17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKYV 245
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824])

HSP 1 Score: 77.411 bits (189), Expect = 2.477e-16
Identity = 58/206 (28.16%), Postives = 97/206 (47.09%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFA 759
             Y   G E+  +  +K Y T S    G  +I+V DIFG+ +  TR  AD++A + +  ++PDFF G+ PW     P  +   F  WL    +   V +++     +L +     K GI+GFCWGG +  +   T +     GVSV+G       V ++K P +F+ A +D  +   +    ++ + + C+ +     F    HGF 
Sbjct:   17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFV 215
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824])

HSP 1 Score: 56.6102 bits (135), Expect = 2.566e-9
Identity = 50/170 (29.41%), Postives = 77/170 (45.29%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD 663
             Y   G E+  +  +K Y T S    G  +I+V DIFG+ +  TR             ++PDFF G+ PW     P  +   F  WL    +   V +++     +L +     K GI+GFCWGG +  +   T +     GVSV+G       V ++K P +F+ A +D
Sbjct:   17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTR------------TIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAEND 167
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Mouse
Match: Cmbl (carboxymethylenebutenolidase-like (Pseudomonas) [Source:MGI Symbol;Acc:MGI:1916824])

HSP 1 Score: 47.7506 bits (112), Expect = 1.278e-6
Identity = 30/87 (34.48%), Postives = 45/87 (51.72%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWL 420
             Y   G E+  +  +K Y T S    G  +I+V DIFG+ +  TR  AD++A + +  ++PDFF G+ PW     P  +   F  WL
Sbjct:   17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWL 98
[Close]
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|O14359|YB4E_SCHPO (Uncharacterized AIM2 family protein C30D10.14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC30D10.14 PE=3 SV=1)

HSP 1 Score: 85.1149 bits (209), Expect = 4.121e-18
Identity = 70/232 (30.17%), Postives = 99/232 (42.67%), Query Frame = 1 
Query:  139 CCTSGQ---PKSDSYVSKGTEINTLSDLKLYHTGS-GNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIV-----EKDLIVARDFLSKAGTTNKPGILGFCWGGK-MSAYACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPS--LDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKE 798
            CC + +     + SY  KG EI     L  Y  GS  N   LI   DIFG + +Q +  AD LA+  F V +PDF  GKP  ++  PPK  ++  K  ND  S  I       K   V     +  G     G  GFCWG K +  Y    DF     S H +        ++  P++FL + D+ +  +   E   K+        F  F  M HG+ AAR D ++   ++
Sbjct:    4 CCPTSRGAAASNKSYTFKGKEIENFGGLTTYVVGSTSNTRVLIGFMDIFGLS-DQIKEGADKLADDGFTVYLPDFLEGKPLPVTALPPKTPED-QKLCNDFFSTRISPNLHWPKLAKVVEAVRANHGPNVTIGTYGFCWGAKVLVTYPATIDFVGIA-SCHPSFPDSADAANVHCPVLFLCSKDEDAKIIKEWEEAFKTNPAYAKSSFETFSDMFHGWMAARADLSNPEQRK 232
[Close]
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7TP52|CMBL_RAT (Carboxymethylenebutenolidase homolog OS=Rattus norvegicus OX=10116 GN=Cmbl PE=2 SV=1)

HSP 1 Score: 82.0333 bits (201), Expect = 6.519e-17
Identity = 65/233 (27.90%), Postives = 109/233 (46.78%), Query Frame = 1 
Query:  172 YVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQT-DFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
            Y   G E+  +  +K Y T S    G  +I+V DIFG+ ++ TR  AD++A + +  ++PDFF G+ PW     P  +   F +WL    +  I  +   V R +L +     K GI+GFCWGG +  +   T      GVSV+G       V ++K P +F+ A +D  +   +  +  + + + C+ +     F    HGF   + +      K  I +     + +LNK+
Sbjct:   18 YGGMGQEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLSNTRYMADMIAGNGYTTIVPDFFVGQEPWD----PAGDWSTFPEWLKSRNARKINREVDAVLR-YLKQQCHAQKIGIVGFCWGGIVVHHVMTTYPEVRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDAVIPLEQVSILIQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKY 244
[Close]
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6P7K0|CMBL_XENTR (Carboxymethylenebutenolidase homolog OS=Xenopus tropicalis OX=8364 GN=cmbl PE=2 SV=1)

HSP 1 Score: 81.6481 bits (200), Expect = 8.946e-17
Identity = 68/235 (28.94%), Postives = 107/235 (45.53%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD-----PSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y +KG E+  +  +K Y     S     +I+V DIFG+ +  TR  ADLL  H +  + PDFF G+ PW  SN    +   F +WL    + T VEK++ V   +L +     K G++GFCWGG ++ +   +      GVS +G         ++  P +F+ A  D       +  +E  LK  S   D     F K  HGF   + +  +   K  I +     + +L+K+
Sbjct:   17 EYGAKGQEVQ-IEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQEPWKPSN----DRSTFTEWLQTRQA-TKVEKEINVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEMDHVIPLEQVSLLEEKLKVHS-KVDFQVKVFPKQTHGFVHRKNEDINPEDKPFIEEARKNMLEWLHKY 244
[Close]
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8R1G2|CMBL_MOUSE (Carboxymethylenebutenolidase homolog OS=Mus musculus OX=10090 GN=Cmbl PE=1 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 3.892e-16
Identity = 63/236 (26.69%), Postives = 108/236 (45.76%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLYHTGSGNKNG--LILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF--YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFH----RFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFA 849
             Y   G E+  +  +K Y T S    G  +I+V DIFG+ +  TR  AD++A + +  ++PDFF G+ PW     P  +   F  WL    +   V +++     +L +     K GI+GFCWGG +  +   T +     GVSV+G       V ++K P +F+ A +D  +   +    ++ + + C+ +     F    HGF   + +      K  I +     + +LNK+ 
Sbjct:   17 EYGGMGHEVQ-VEHIKAYVTRSPVDAGKAVIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWD----PAGDWSTFPAWLKSRNARK-VNREVDAVLRYLRQQCHAQKIGIVGFCWGG-VVVHQVMTAYPDIRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKYV 245
[Close]
BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5XH09|CMBL_XENLA (Carboxymethylenebutenolidase homolog OS=Xenopus laevis OX=8355 GN=cmbl PE=2 SV=1)

HSP 1 Score: 77.7962 bits (190), Expect = 2.183e-15
Identity = 63/211 (29.86%), Postives = 97/211 (45.97%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNN-DEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDD-----PSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGD 774
             Y +KG EI  +  +K Y     S     +I+V DIFG+ +  TR  ADLL  H +  + PDFF G+     ++ P N+   F +WL    + T VEK++ V   +L +     K G++GFCWGG ++ +   +      GVS +G         ++  P +F+ A  D       +  +E  LK  S   D     F K  HGF   + +
Sbjct:   17 EYGAKGQEIQ-IEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQ----ESWKPSNDWSTFTEWLQTRQA-TKVEKEMNVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEIDHVIPLEQVSLLEQKLKVHS-KVDFQIKVFPKQTHGFVHRKKE 220
[Close]
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A5J4NS28 (DLH domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0015288 PE=4 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 2.904e-77
Identity = 124/267 (46.44%), Postives = 166/267 (62.17%), Query Frame = 1 
Query:  109 SNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLY----------HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHS-FNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG--TTNKPGILGFCWGGKMSAYACQTDF--------YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
            S+ME++GIKVCCTSG P +     K T + T++ L              T   NK+ ++LVYDIFGF++ QTRRFADLLAE +   V+MPDFFRG+PW L NFPPK+   F+ W+  AG + I+ +DL  AR++L   G   T   GI+GFCWGGK +  AC            +T GVS+HGA      V    VPM+F+PAGDDP++D ++ +L  K  G  C +HRFD   HGFAAARGDWN  +T+++I K ++L+  F NKF
Sbjct:   52 SSMEEQGIKVCCTSGTPTATGGCEKYTPLGTVACLSTSGPRGYLAMPSATQVTNKSAILLVYDIFGFDIVQTRRFADLLAEKTRMRVLMPDFFRGQPWLLQNFPPKDRSHFINWVEQAGRWDIISEDLKCAREYLLTNGLDATASFGIIGFCWGGKQAIRACSGQSHARHLGFSFTAGVSLHGAFFGPDDVEHATVPMLFMPAGDDPAIDPLKAVLDKKPFGHQCAYHRFDTETHGFAAARGDWNIPHTRQAIEKALTLTAEFFNKF 318
[Close]
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A4S2LFZ4 (DLH domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009126 PE=4 SV=1)

HSP 1 Score: 241.891 bits (616), Expect = 3.107e-75
Identity = 123/266 (46.24%), Postives = 164/266 (61.65%), Query Frame = 1 
Query:  109 SNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDL-----KLYHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG--TTNKPGILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843
            S+M++ GIKVCC+SG P +       + +  L  L       Y+T        N + LI+VYDIFG ++ QTRRFADLLAE +   VVMPDFFRG+PW L NFPPK+  EF+KW+  AGS+ +V  DL  A +FL   G  ++   GI+GFCWGGK +  AC  D +          GVS+HGA +      D+ VPM+F+PAGDDP +  ++ +L  K  G  C +HRFD   HGFAAARGDWN  +T+E+I+K + L+ NF NK
Sbjct:   27 SSMKESGIKVCCSSGTPSATGGCGDYSPVGKLVQLTASGPAAYYTRPKEGPLCNSSALIVVYDIFGIDILQTRRFADLLAERTHRRVVMPDFFRGRPWLLKNFPPKDGGEFVKWVETAGSWDVVSADLKSAHEFLLADGLNSSAPLGIIGFCWGGKQAVRACSGDSHARELGFKFLAGVSLHGAFLGPEDAEDLTVPMLFMPAGDDPDVGPIKVILDKKPFGAQCAYHRFDSETHGFAAARGDWNVPHTREAIMKALDLTANFFNK 292
[Close]
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A1S8WYI4 (Carboxymethylenebutenolidase OS=Opisthorchis viverrini OX=6198 GN=X801_04659 PE=4 SV=1)

HSP 1 Score: 236.113 bits (601), Expect = 2.796e-73
Identity = 122/267 (45.69%), Postives = 162/267 (60.67%), Query Frame = 1 
Query:  106 FSNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKL-----YHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG-TTNKP-GILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843
             S+M++ GIKVCC+SG P +       + +  L  L       Y+T        + + LI++YDIFG ++ QTRRF DLLAE +   VVMPD FRG PW L NFPPKN  EF+KW+  AGS+ IV  DL  A +FL   G +++ P GILGFCWGGK +  AC  D +          GVS+HGA +       + VPM+F+PAGDDP +  ++ +L  K  G  C +HRFD   HGFAAARGDWN  +T+E+I+K + L+V F NK
Sbjct:    1 MSSMKESGIKVCCSSGTPSATGGCGDYSPVGKLVQLAAPGPTAYYTQPKEGPLCSNSALIVIYDIFGIDILQTRRFVDLLAEKTHRRVVMPDVFRGHPWLLKNFPPKNGGEFVKWVETAGSWEIVSADLKSAHEFLLADGLSSSAPLGILGFCWGGKQAIRACSGDSHASKLGFKFLAGVSLHGAFLGPEDAKHVTVPMLFMPAGDDPDIGPIKEILDKKPFGTQCAYHRFDSETHGFAAARGDWNVPHTREAIMKALDLAVEFFNK 267
[Close]
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A074ZZR4 (DLH domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_01045 PE=4 SV=1)

HSP 1 Score: 234.572 bits (597), Expect = 1.321e-72
Identity = 121/267 (45.32%), Postives = 161/267 (60.30%), Query Frame = 1 
Query:  106 FSNMEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKL-----YHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG-TTNKP-GILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843
             S+M++ GIKVCC+SG P +       + +  L  L       Y+         + + LI++YDIFG ++ QTRRF DLLAE +   VVMPD FRG PW L NFPPKN  EF+KW+  AGS+ IV  DL  A +FL   G +++ P GILGFCWGGK +  AC  D +          GVS+HGA +       + VPM+F+PAGDDP +  ++ +L  K  G  C +HRFD   HGFAAARGDWN  +T+E+I+K + L+V F NK
Sbjct:    1 MSSMKESGIKVCCSSGTPSATGGCGDYSPVGKLVQLAAPGPTAYYAQPKEGPLCSNSALIVIYDIFGIDILQTRRFVDLLAEKTHRRVVMPDVFRGHPWLLKNFPPKNGGEFVKWVETAGSWEIVSADLKSAHEFLLADGLSSSAPLGILGFCWGGKQAIRACSGDSHASKLGFKFLAGVSLHGAFLGPEDAKHVTVPMLFMPAGDDPDIGPIKEILDKKPFGTQCAYHRFDSETHGFAAARGDWNVPHTREAIMKALDLAVEFFNK 267
[Close]
BLAST of DLH domain-containing protein vs. TrEMBL
Match: A0A419Q1Y0 (Carboxymethylenebutenolidase-like protein OS=Clonorchis sinensis OX=79923 GN=CMBL PE=4 SV=1)

HSP 1 Score: 236.498 bits (602), Expect = 8.032e-72
Identity = 123/268 (45.90%), Postives = 163/268 (60.82%), Query Frame = 1 
Query:  106 FSNMEKEGIKVCCTSGQPKSD------SYVSKGTEINTLSDLKLYHTGSG-----NKNGLILVYDIFGFNVNQTRRFADLLAEHSFN-VVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAG--TTNKPGILGFCWGGKMSAYACQTDFYT--------CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNK 843
             S M+K GI+VCC SG+P +       S V K  ++ T S    Y+T        N + LI++YDIFG ++ QTRRFADLLAE +   VVMPD FRG+PW L NFPPK+  EF+KW+  AGS+ +V  DL  A +FL   G  ++   GILGFCWGGK +  AC  D Y          GVS+HGA +       + VPM+F+PAGDDP +  ++ +L  K  G  C +HRFD   HGFAAARGDWN  +T+++I+K + L+  F NK
Sbjct:  125 MSPMKKHGIRVCCRSGRPSATGGCGNYSPVGKVVQL-TRSGPAAYYTRPKRGRLLNSSALIVIYDIFGIDILQTRRFADLLAERTHRRVVMPDVFRGRPWLLKNFPPKDGGEFIKWVETAGSWDVVSADLKSAHEFLLADGLNSSAPLGILGFCWGGKQAIQACSGDSYARKLGFKFLAGVSLHGAFLGPEDAKHVTVPMLFMPAGDDPDIGPIKVILDKKPFGAQCAYHRFDSETHGFAAARGDWNVSHTRKAIMKALDLTAEFFNK 391
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Cavefish
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:103047512])

HSP 1 Score: 90.5077 bits (223), Expect = 5.859e-21
Identity = 68/235 (28.94%), Postives = 113/235 (48.09%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP-----SLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y S G E+  +  +K Y     +  +  +I++ DIFG+ +  TR  AD++A + +  + PDFF GK PWS    P  +   F +WL D    T + K++ V   +L +   + + G++GFCWGG  + Y + Q      GVSV+G    +    ++K P +F+ A +D       +  +E  LK K    D     F    HGF   + +  +E  +  I +     +N+LNK+
Sbjct:   17 EYGSLGEEVQ-IDHIKAYVVKPKAPTEKAIIVIQDIFGWQLPNTRYMADMVASNGYIAICPDFFVGKQPWS----PTDDWATFQQWLEDKNP-TKINKEVDVVLKYLKEKCGSKRIGVVGFCWGGVATHYISLQYPEIKAGVSVYGIVREKEDRYELKSPTLFIFAENDAVIPLEQVTTLEANLKDKC-KVDFQVKIFPDQTHGFVHRKREDINEADRRYIQEARGDLINWLNKY 244
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Sea Lamprey
Match: cmbl (carboxymethylenebutenolidase homolog (Pseudomonas) [Source:ZFIN;Acc:ZDB-GENE-071004-21])

HSP 1 Score: 90.8929 bits (224), Expect = 9.616e-22
Identity = 68/238 (28.57%), Postives = 113/238 (47.48%), Query Frame = 1 
Query:  172 YVSKGTEINT------LSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF-YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGK---DCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
            Y  +G E+        LS  +    G  +  GLI++ DI+G+ +  TR  AD LA   +  ++PDFF GK PWS    P  +   F +WL D  + T +  ++  A D+L K     + G+LGFCWGG    +   T+     GVS +G    E     +K P++++   +DP   LD V+ +L+ + + +   D     F    HGF   + +      ++ I +  +  + +LNK+
Sbjct:   18 YSGQGQEVRAGHVDSYLSAAQPGANGEASVRGLIIIQDIYGWKLPNTRFIADWLAGQGYTCIVPDFFLGKEPWS----PSHDWSTFQEWLKDKQA-TNIGTEIDAAMDYLKKECGVQRIGVLGFCWGGLAVHHLLLTNSELQAGVSCYGIIKIEESRYALKNPVLYIFGENDPLIPLDTVQ-LLEKRLVAECQVDVQVKVFPGQTHGFVHRKHEDISPADEQHIKEARANLLAWLNKY 249
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Sea Lamprey
Match: cmbl (carboxymethylenebutenolidase homolog (Pseudomonas) [Source:ZFIN;Acc:ZDB-GENE-071004-21])

HSP 1 Score: 91.2781 bits (225), Expect = 9.619e-22
Identity = 77/285 (27.02%), Postives = 124/285 (43.51%), Query Frame = 1 
Query:   31 KTKLLTIIMVTNLFVKNRNFNLIRLFSNMEKEGIKVCCTSGQPKSDSYVSKGTEINT------LSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDF-YTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGK---DCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
            K K         +FV   + N       M  E     C  G      Y  +G E+        LS  +    G  +  GLI++ DI+G+ +  TR  AD LA   +  ++PDFF GK PWS    P  +   F +WL D  + T +  ++  A D+L K     + G+LGFCWGG    +   T+     GVS +G    E     +K P++++   +DP   LD V+ +L+ + + +   D     F    HGF   + +      ++ I +  +  + +LNK+
Sbjct:    1 KQKFPPPPRGPPVFVNEHSENSQGRGEKMANEAKPCPCELGDVMP--YSGQGQEVRAGHVDSYLSAAQPGANGEASVRGLIIIQDIYGWKLPNTRFIADWLAGQGYTCIVPDFFLGKEPWS----PSHDWSTFQEWLKDKQA-TNIGTEIDAAMDYLKKECGVQRIGVLGFCWGGLAVHHLLLTNSELQAGVSCYGIIKIEESRYALKNPVLYIFGENDPLIPLDTVQ-LLEKRLVAECQVDVQVKVFPGQTHGFVHRKHEDISPADEQHIKEARANLLAWLNKY 277
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Medaka
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:101171616])

HSP 1 Score: 90.1225 bits (222), Expect = 8.060e-21
Identity = 74/235 (31.49%), Postives = 111/235 (47.23%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGKDCVFHR---FDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y   G E+  +  +K Y     S     +I+++DIFG+ +  TR  A++LA   +  V PDFF GK PWS    P  +  +F +WL D    TI  K++    ++L +     + G +GFCWGG  + Y A Q      GVSV+G          +K P +F+ A  D    LD V N L++K   K  V H+   F    HGF   + +  +   K  I +     +N+LNK+
Sbjct:   17 EYGGLGQEVQ-MEHIKAYVVKPTSPKDKAVIVIHDIFGWQLPNTRYMAEMLAADGYIAVCPDFFVGKEPWS----PAGDWSKFQEWLQDKKPTTI-NKEVDAVLNYLKEQCGAKRIGTVGFCWGGVATHYIALQYPEVKAGVSVYGIVREREDRYALKSPTLFIFAEVDQVIPLDQV-NALEAKLKEKCTVEHQVKIFPGQTHGFVHRKREDINPADKPYIQEARKDMLNWLNKY 244
[Close]
BLAST of DLH domain-containing protein vs. Ensembl Medaka
Match: cmbl (carboxymethylenebutenolidase homolog [Source:NCBI gene;Acc:101171616])

HSP 1 Score: 90.1225 bits (222), Expect = 8.060e-21
Identity = 74/235 (31.49%), Postives = 111/235 (47.23%), Query Frame = 1 
Query:  169 SYVSKGTEINTLSDLKLY--HTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGK-PWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAY-ACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDP--SLDGVENMLKSKSIGKDCVFHR---FDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKF 846
             Y   G E+  +  +K Y     S     +I+++DIFG+ +  TR  A++LA   +  V PDFF GK PWS    P  +  +F +WL D    TI  K++    ++L +     + G +GFCWGG  + Y A Q      GVSV+G          +K P +F+ A  D    LD V N L++K   K  V H+   F    HGF   + +  +   K  I +     +N+LNK+
Sbjct:   17 EYGGLGQEVQ-MEHIKAYVVKPTSPKDKAVIVIHDIFGWQLPNTRYMAEMLAADGYIAVCPDFFVGKEPWS----PAGDWSKFQEWLQDKKPTTI-NKEVDAVLNYLKEQCGAKRIGTVGFCWGGVATHYIALQYPEVKAGVSVYGIVREREDRYALKSPTLFIFAEVDQVIPLDQV-NALEAKLKEKCTVEHQVKIFPGQTHGFVHRKREDINPADKPYIQEARKDMLNWLNKY 244
[Close]
BLAST of DLH domain-containing protein vs. Planmine SMEST
Match: SMESG000077560.1 (SMESG000077560.1)

HSP 1 Score: 509.605 bits (1311), Expect = 0.000e+0
Identity = 245/246 (99.59%), Postives = 245/246 (99.59%), Query Frame = 1 
Query:  115 MEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFAK 852
            MEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDFY CGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFAK
Sbjct:    1 MEKEGIKVCCTSGQPKSDSYVSKGTEINTLSDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFFRGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNKPGILGFCWGGKMSAYACQTDFYRCGVSVHGAGITEHLVNDIKVPMMFLPAGDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESILKVISLSVNFLNKFAK 246
The following BLAST results are available for this feature:
BLAST of DLH domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CMBL8.354e-1625.64carboxymethylenebutenolidase homolog [Source:HGNC ... [more]
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BLAST of DLH domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DLH domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DLH domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cmbl1.590e-2230.77carboxymethylenebutenolidase homolog (Pseudomonas)... [more]
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BLAST of DLH domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cmbl1.689e-1728.94carboxymethylenebutenolidase homolog [Source:NCBI ... [more]
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BLAST of DLH domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Cmbl5.563e-1726.69carboxymethylenebutenolidase-like (Pseudomonas) [S... [more]
Cmbl2.477e-1628.16carboxymethylenebutenolidase-like (Pseudomonas) [S... [more]
Cmbl2.566e-929.41carboxymethylenebutenolidase-like (Pseudomonas) [S... [more]
Cmbl1.278e-634.48carboxymethylenebutenolidase-like (Pseudomonas) [S... [more]
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BLAST of DLH domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O14359|YB4E_SCHPO4.121e-1830.17Uncharacterized AIM2 family protein C30D10.14 OS=S... [more]
sp|Q7TP52|CMBL_RAT6.519e-1727.90Carboxymethylenebutenolidase homolog OS=Rattus nor... [more]
sp|Q6P7K0|CMBL_XENTR8.946e-1728.94Carboxymethylenebutenolidase homolog OS=Xenopus tr... [more]
sp|Q8R1G2|CMBL_MOUSE3.892e-1626.69Carboxymethylenebutenolidase homolog OS=Mus muscul... [more]
sp|Q5XH09|CMBL_XENLA2.183e-1529.86Carboxymethylenebutenolidase homolog OS=Xenopus la... [more]
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BLAST of DLH domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5J4NS282.904e-7746.44DLH domain-containing protein OS=Paragonimus weste... [more]
A0A4S2LFZ43.107e-7546.24DLH domain-containing protein OS=Opisthorchis feli... [more]
A0A1S8WYI42.796e-7345.69Carboxymethylenebutenolidase OS=Opisthorchis viver... [more]
A0A074ZZR41.321e-7245.32DLH domain-containing protein OS=Opisthorchis vive... [more]
A0A419Q1Y08.032e-7245.90Carboxymethylenebutenolidase-like protein OS=Clono... [more]
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BLAST of DLH domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cmbl5.859e-2128.94carboxymethylenebutenolidase homolog [Source:NCBI ... [more]
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BLAST of DLH domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cmbl9.616e-2228.57carboxymethylenebutenolidase homolog (Pseudomonas)... [more]
cmbl9.619e-2227.02carboxymethylenebutenolidase homolog (Pseudomonas)... [more]
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BLAST of DLH domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DLH domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DLH domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cmbl8.060e-2131.49carboxymethylenebutenolidase homolog [Source:NCBI ... [more]
cmbl8.060e-2131.49carboxymethylenebutenolidase homolog [Source:NCBI ... [more]
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BLAST of DLH domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000077560.10.000e+099.59SMESG000077560.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033810 ID=SMED30033810|Name=DLH domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=921bp
ATTTGCAAAATTATAAATGTTTCATAAATAAAAACTAAATTATTAACCAT
AATAATGGTTACAAATTTGTTTGTTAAGAATAGAAATTTTAACTTAATAA
GACTATTTTCCAATATGGAAAAAGAAGGTATTAAAGTATGCTGTACATCT
GGTCAACCTAAATCTGATTCTTATGTCAGCAAAGGAACAGAAATAAATAC
ATTATCTGATCTAAAATTATATCACACTGGTAGTGGAAATAAAAATGGAC
TCATTCTTGTTTATGATATTTTTGGATTCAATGTCAACCAAACTAGACGA
TTTGCAGATTTATTAGCTGAACATTCCTTTAATGTTGTAATGCCGGATTT
TTTCCGAGGTAAACCGTGGAGCTTAAGTAATTTTCCTCCAAAGAATAACG
ACGAATTTATGAAATGGTTGAATGATGCTGGATCTTATACTATTGTGGAA
AAGGATTTGATTGTAGCAAGAGATTTCTTAAGTAAAGCAGGTACCACTAA
TAAGCCTGGTATTTTAGGATTTTGTTGGGGAGGAAAAATGTCTGCTTACG
CTTGTCAAACTGACTTTTATACGTGTGGCGTGTCGGTTCATGGGGCAGGA
ATCACTGAACATTTAGTAAATGATATAAAAGTTCCCATGATGTTTTTACC
TGCTGGTGACGATCCATCATTAGACGGAGTGGAAAATATGCTGAAATCCA
AATCAATAGGAAAAGATTGTGTATTTCATCGCTTTGACAAAATGAAGCAT
GGATTTGCGGCTGCTAGGGGAGACTGGAACGATGAAAATACAAAAGAATC
TATTTTAAAGGTTATTTCTCTTTCTGTCAACTTTTTGAATAAATTTGCCA
AATAAGCAAATAAAATTCGTCGACTTAATTTGGTATATGGTTCAATAAAT
TTTTATAAATTGAAAAAAAAA
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protein sequence of SMED30033810-orf-1

>SMED30033810-orf-1 ID=SMED30033810-orf-1|Name=SMED30033810-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=267bp
MVTNLFVKNRNFNLIRLFSNMEKEGIKVCCTSGQPKSDSYVSKGTEINTL
SDLKLYHTGSGNKNGLILVYDIFGFNVNQTRRFADLLAEHSFNVVMPDFF
RGKPWSLSNFPPKNNDEFMKWLNDAGSYTIVEKDLIVARDFLSKAGTTNK
PGILGFCWGGKMSAYACQTDFYTCGVSVHGAGITEHLVNDIKVPMMFLPA
GDDPSLDGVENMLKSKSIGKDCVFHRFDKMKHGFAAARGDWNDENTKESI
LKVISLSVNFLNKFAK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000429neoblast
PLANA:0002089reproductive organ
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR002925Dienelactn_hydro
IPR029058AB_hydrolase
Vocabulary: molecular function
TermDefinition
GO:0016787hydrolase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002925Dienelactone hydrolasePFAMPF01738DLHcoord: 62..249
e-value: 2.4E-20
score: 73.0
IPR029058Alpha/Beta hydrolase foldGENE3DG3DSA:3.40.50.1820coord: 42..264
e-value: 3.2E-32
score: 113.9
IPR029058Alpha/Beta hydrolase foldSUPERFAMILYSSF53474alpha/beta-Hydrolasescoord: 55..253
NoneNo IPR availablePANTHERPTHR47668FAMILY NOT NAMEDcoord: 27..263