Tyrosine-protein kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033752 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 17Note: Hover over icons to view figure legend
Homology
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: CSK (C-terminal Src kinase [Source:HGNC Symbol;Acc:HGNC:2444]) HSP 1 Score: 351.288 bits (900), Expect = 1.902e-116 Identity = 174/377 (46.15%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRI+Y + +IDEE YF +L +LVE Y SDA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP+F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: CSK (C-terminal Src kinase [Source:HGNC Symbol;Acc:HGNC:2444]) HSP 1 Score: 351.288 bits (900), Expect = 1.902e-116 Identity = 174/377 (46.15%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRI+Y + +IDEE YF +L +LVE Y SDA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP+F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: CSK (C-terminal Src kinase [Source:HGNC Symbol;Acc:HGNC:2444]) HSP 1 Score: 351.288 bits (900), Expect = 1.902e-116 Identity = 174/377 (46.15%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRI+Y + +IDEE YF +L +LVE Y SDA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP+F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: MATK (megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6906]) HSP 1 Score: 304.294 bits (778), Expect = 6.286e-98 Identity = 152/381 (39.90%), Postives = 235/381 (61.68%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILS 1200
L M W+HG I+ + A Q L P E+GLFL+RES +PGD+ LCV + V HYR+++ + TIDE +F +L ++VE Y D + T L +P K G +AGW+ L L +G+G+F V + Y G+ +A K + D+T + E +VMT ++H+NLV+ G+++ +Y++ E++ G+LVN+LRTRG++ + L FS++VA GM YLE K LVHRDLA RNIL+ +++VAK++DFGL + R+P+KWTAPEA+K+ +F+ SD+WSFGV+LWE++S+G+ PY +S++ V +E+G+R+ P+ CP ++ LM + W PA RP F++ + L L S + S
Sbjct: 76 LSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK---SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPAS 449
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: MATK (megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6906]) HSP 1 Score: 303.908 bits (777), Expect = 2.823e-97 Identity = 152/381 (39.90%), Postives = 235/381 (61.68%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILS 1200
L M W+HG I+ + A Q L P E+GLFL+RES +PGD+ LCV + V HYR+++ + TIDE +F +L ++VE Y D + T L +P K G +AGW+ L L +G+G+F V + Y G+ +A K + D+T + E +VMT ++H+NLV+ G+++ +Y++ E++ G+LVN+LRTRG++ + L FS++VA GM YLE K LVHRDLA RNIL+ +++VAK++DFGL + R+P+KWTAPEA+K+ +F+ SD+WSFGV+LWE++S+G+ PY +S++ V +E+G+R+ P+ CP ++ LM + W PA RP F++ + L L S + S
Sbjct: 118 LSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK---SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPAS 491
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 324.709 bits (831), Expect = 2.069e-105 Identity = 158/388 (40.72%), Postives = 239/388 (61.60%), Query Frame = 1
Query: 76 WYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPL---------------PKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGI-KEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYE---LGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
W+H I+RE E+LL + +G FL+RES N+PGDFTLC+ + V+HYRI + T D+EEYFS+L +LV Y DA+GL L P+ S F+ AG V + +D+ + +G G+F +V YK + +A K + + + EA M + H NLV G+V+D +Y++TEYM NG+L++ LR+RG+ + +MF++++ GM YLE K +VHRDLA RN+LLD ++VAK++DFGL ++ +S G+ PIKWTAPEA++++QF+ SD+WSFG++LWEI+SFG++PY I +Q V+ IE+G+R+ P+ CPPEI+ +M+ W ++ RP+F Q + LTTI N+
Sbjct: 151 WFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNT 538
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 324.709 bits (831), Expect = 2.069e-105 Identity = 158/388 (40.72%), Postives = 239/388 (61.60%), Query Frame = 1
Query: 76 WYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPL---------------PKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGI-KEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYE---LGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
W+H I+RE E+LL + +G FL+RES N+PGDFTLC+ + V+HYRI + T D+EEYFS+L +LV Y DA+GL L P+ S F+ AG V + +D+ + +G G+F +V YK + +A K + + + EA M + H NLV G+V+D +Y++TEYM NG+L++ LR+RG+ + +MF++++ GM YLE K +VHRDLA RN+LLD ++VAK++DFGL ++ +S G+ PIKWTAPEA++++QF+ SD+WSFG++LWEI+SFG++PY I +Q V+ IE+G+R+ P+ CPPEI+ +M+ W ++ RP+F Q + LTTI N+
Sbjct: 151 WFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNT 538
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 325.094 bits (832), Expect = 1.356e-104 Identity = 158/388 (40.72%), Postives = 239/388 (61.60%), Query Frame = 1
Query: 76 WYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPL---------------PKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGI-KEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYE---LGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
W+H I+RE E+LL + +G FL+RES N+PGDFTLC+ + V+HYRI + T D+EEYFS+L +LV Y DA+GL L P+ S F+ AG V + +D+ + +G G+F +V YK + +A K + + + EA M + H NLV G+V+D +Y++TEYM NG+L++ LR+RG+ + +MF++++ GM YLE K +VHRDLA RN+LLD ++VAK++DFGL ++ +S G+ PIKWTAPEA++++QF+ SD+WSFG++LWEI+SFG++PY I +Q V+ IE+G+R+ P+ CPPEI+ +M+ W ++ RP+F Q + LTTI N+
Sbjct: 236 WFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNT 623
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 325.094 bits (832), Expect = 1.356e-104 Identity = 158/388 (40.72%), Postives = 239/388 (61.60%), Query Frame = 1
Query: 76 WYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPL---------------PKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGI-KEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYE---LGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
W+H I+RE E+LL + +G FL+RES N+PGDFTLC+ + V+HYRI + T D+EEYFS+L +LV Y DA+GL L P+ S F+ AG V + +D+ + +G G+F +V YK + +A K + + + EA M + H NLV G+V+D +Y++TEYM NG+L++ LR+RG+ + +MF++++ GM YLE K +VHRDLA RN+LLD ++VAK++DFGL ++ +S G+ PIKWTAPEA++++QF+ SD+WSFG++LWEI+SFG++PY I +Q V+ IE+G+R+ P+ CPPEI+ +M+ W ++ RP+F Q + LTTI N+
Sbjct: 236 WFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNT 623
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: abl-1 (Tyrosine-protein kinase abl-1 [Source:UniProtKB/Swiss-Prot;Acc:P03949]) HSP 1 Score: 259.61 bits (662), Expect = 4.371e-76 Identity = 143/384 (37.24%), Postives = 212/384 (55.21%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKS----GLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGK--ILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR--ETDSY--ELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
L WYHG I+R +E +L G FL+RES G +T+ V + V HYRI D ++ I +E F +L ELV + A+GL+ L P K GL P W R + + LG G + +V++ ++K +A K + + + + EA++M + H+NLV+ G+ Y++TE+M NG+L+ YLR KS + PI + + +A GMSYLE + +HRDLA RN L+ ++ + KIADFGL R + D+Y G + PIKWTAPE + N FS SD+W+FGV+LWEI ++G PY G+ + +V +E GFR+ PQ CPP +Y LM W +P+ RP F+ H L +++S
Sbjct: 174 LDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNA----PDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLISS 553
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Csk (gene:FBgn0262081 transcript:FBtr0300549) HSP 1 Score: 390.578 bits (1002), Expect = 1.379e-128 Identity = 193/384 (50.26%), Postives = 264/384 (68.75%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELG-GRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNS 1191
++ EV L +M W+HG ITR+ AE LL PRE+GLFL+RES N+PGD+TLCVC+Q V+HYR+ Y + + TID+EEYF +L +LV Y +DA+GL T L K LPK G + F GWV P L L E +GKG+F +V + + +A K +++ + EASVMTT+ H NLV+F GLV S +YL+TEYM GSLV+YLR+RG+ IT +Q++F+ + A GM YLE K +VHRDLA RN+L+ ++ VAK++DFGL RE + Y L G++PIKWTAPEA+KN +FS SDMWSFG++LWEIYSFG++PY I + V+ +E G+++ P+ CPPEIY +M AW +NPA RP F + KV +LN+ +
Sbjct: 344 SRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKY-LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVK-MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL-KVKLQLLNNATA 723
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Csk (gene:FBgn0262081 transcript:FBtr0300547) HSP 1 Score: 390.578 bits (1002), Expect = 1.379e-128 Identity = 193/384 (50.26%), Postives = 264/384 (68.75%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELG-GRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNS 1191
++ EV L +M W+HG ITR+ AE LL PRE+GLFL+RES N+PGD+TLCVC+Q V+HYR+ Y + + TID+EEYF +L +LV Y +DA+GL T L K LPK G + F GWV P L L E +GKG+F +V + + +A K +++ + EASVMTT+ H NLV+F GLV S +YL+TEYM GSLV+YLR+RG+ IT +Q++F+ + A GM YLE K +VHRDLA RN+L+ ++ VAK++DFGL RE + Y L G++PIKWTAPEA+KN +FS SDMWSFG++LWEIYSFG++PY I + V+ +E G+++ P+ CPPEIY +M AW +NPA RP F + KV +LN+ +
Sbjct: 344 SRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKY-LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVK-MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL-KVKLQLLNNATA 723
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Csk (gene:FBgn0262081 transcript:FBtr0300548) HSP 1 Score: 390.578 bits (1002), Expect = 1.379e-128 Identity = 193/384 (50.26%), Postives = 264/384 (68.75%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELG-GRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNS 1191
++ EV L +M W+HG ITR+ AE LL PRE+GLFL+RES N+PGD+TLCVC+Q V+HYR+ Y + + TID+EEYF +L +LV Y +DA+GL T L K LPK G + F GWV P L L E +GKG+F +V + + +A K +++ + EASVMTT+ H NLV+F GLV S +YL+TEYM GSLV+YLR+RG+ IT +Q++F+ + A GM YLE K +VHRDLA RN+L+ ++ VAK++DFGL RE + Y L G++PIKWTAPEA+KN +FS SDMWSFG++LWEIYSFG++PY I + V+ +E G+++ P+ CPPEIY +M AW +NPA RP F + KV +LN+ +
Sbjct: 344 SRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKY-LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVK-MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL-KVKLQLLNNATA 723
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Csk (gene:FBgn0262081 transcript:FBtr0299728) HSP 1 Score: 390.578 bits (1002), Expect = 1.379e-128 Identity = 193/384 (50.26%), Postives = 264/384 (68.75%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELG-GRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNS 1191
++ EV L +M W+HG ITR+ AE LL PRE+GLFL+RES N+PGD+TLCVC+Q V+HYR+ Y + + TID+EEYF +L +LV Y +DA+GL T L K LPK G + F GWV P L L E +GKG+F +V + + +A K +++ + EASVMTT+ H NLV+F GLV S +YL+TEYM GSLV+YLR+RG+ IT +Q++F+ + A GM YLE K +VHRDLA RN+L+ ++ VAK++DFGL RE + Y L G++PIKWTAPEA+KN +FS SDMWSFG++LWEIYSFG++PY I + V+ +E G+++ P+ CPPEIY +M AW +NPA RP F + KV +LN+ +
Sbjct: 344 SRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKY-LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVK-MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL-KVKLQLLNNATA 723
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Csk (gene:FBgn0262081 transcript:FBtr0300546) HSP 1 Score: 391.734 bits (1005), Expect = 4.558e-128 Identity = 193/384 (50.26%), Postives = 264/384 (68.75%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELG-GRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNS 1191
++ EV L +M W+HG ITR+ AE LL PRE+GLFL+RES N+PGD+TLCVC+Q V+HYR+ Y + + TID+EEYF +L +LV Y +DA+GL T L K LPK G + F GWV P L L E +GKG+F +V + + +A K +++ + EASVMTT+ H NLV+F GLV S +YL+TEYM GSLV+YLR+RG+ IT +Q++F+ + A GM YLE K +VHRDLA RN+L+ ++ VAK++DFGL RE + Y L G++PIKWTAPEA+KN +FS SDMWSFG++LWEIYSFG++PY I + V+ +E G+++ P+ CPPEIY +M AW +NPA RP F + KV +LN+ +
Sbjct: 426 SRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKY-LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVK-MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL-KVKLQLLNNATA 805
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: csk (C-terminal Src kinase [Source:ZFIN;Acc:ZDB-GENE-061103-493]) HSP 1 Score: 355.14 bits (910), Expect = 3.512e-118 Identity = 169/381 (44.36%), Postives = 248/381 (65.09%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSD-KIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSK 1185
KS L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRIIY + +IDEEEYF +L +L+E Y DA+GL T L KP G F ++GW R L L + +GKG+F +V Y+GK +A KC+ + + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG++ I + FS++V M YLE + VHRDLA RN+L+ ++ +AK++DFGL +E S + ++P+KWT+PEA++ +FS SD+WS+G++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ RP+F+ + L I+ ++
Sbjct: 72 KSASKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIIY-HNGKLSIDEEEYFENLMQLMEHYTKDADGLCTRLIKPKIMEGTV---AAQDEFSRSGWALNRKELKLIQTIGKGEFGDVMVGDYRGKKVAVKCIKHDATAQAF-VAEASVMTQLRHNNLVQLLGVIVEEKGSLYIVTEYMAKGSLVDYLRSRGRTVIGGDRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTAKLPVKWTSPEALREKKFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFRDLREKLQDIITNE 447
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070705-183]) HSP 1 Score: 315.849 bits (808), Expect = 5.753e-103 Identity = 154/368 (41.85%), Postives = 233/368 (63.32%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVL 1164
L M W+HG I + A L P E+GLFL+RESV +PGDF LCVC+ V HYR+IY + + TID ++F +L +++EFY + + T L KP K GL + ++GW+ L L E +G+G+F VF Y G+ +A K +I+ ++E SVMT + H+NLV G+++ + ++++TE M G+LVN+LR+RG+ ++ I L F+++V GM +LE K L+HRDLA RNIL+ ++ VAKI+DFGL R ++P+KWTAPEA+KN +FS SD+WS+GV+LWEI+S+G+ PY ++V V +E+G+R+ P CP ++YS+M + W P RP+F + + L
Sbjct: 75 LSLMPWFHGKIAGQQAVDKLKPTEDGLFLVRESVRHPGDFVLCVCFSQKVFHYRVIY-QDNKLTIDNMQFFDNLIDMIEFYSRNRGAIATLLLKPKKKEGLKSAETKL---LKSGWLLDLSKLTLGEIIGEGEFGAVFAGEYTGQRVAVK-IIKCDVTAQAFLEETSVMTNLHHKNLVPLLGVIL-HNGLHIVTELMTKGNLVNFLRSRGRFAVSVIQLLRFALDVCEGMEHLESKKLLHRDLAGRNILVSEDGVAKISDFGLARVGSMAVDNSKLPVKWTAPEALKNKKFSTQSDVWSYGVLLWEIFSYGRQPYPKMTVNEVKECVEKGYRMDPPDECPADVYSIMTSCWQTEPKKRPSFHKLRERL 436
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070705-183]) HSP 1 Score: 315.464 bits (807), Expect = 7.826e-103 Identity = 154/368 (41.85%), Postives = 233/368 (63.32%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVL 1164
L M W+HG I + A L P E+GLFL+RESV +PGDF LCVC+ V HYR+IY + + TID ++F +L +++EFY + + T L KP K GL + ++GW+ L L E +G+G+F VF Y G+ +A K +I+ ++E SVMT + H+NLV G+++ + ++++TE M G+LVN+LR+RG+ ++ I L F+++V GM +LE K L+HRDLA RNIL+ ++ VAKI+DFGL R ++P+KWTAPEA+KN +FS SD+WS+GV+LWEI+S+G+ PY ++V V +E+G+R+ P CP ++YS+M + W P RP+F + + L
Sbjct: 72 LSLMPWFHGKIAGQQAVDKLKPTEDGLFLVRESVRHPGDFVLCVCFSQKVFHYRVIY-QDNKLTIDNMQFFDNLIDMIEFYSRNRGAIATLLLKPKKKEGLKSAETKL---LKSGWLLDLSKLTLGEIIGEGEFGAVFAGEYTGQRVAVK-IIKCDVTAQAFLEETSVMTNLHHKNLVPLLGVIL-HNGLHIVTELMTKGNLVNFLRSRGRFAVSVIQLLRFALDVCEGMEHLESKKLLHRDLAGRNILVSEDGVAKISDFGLARVGSMAVDNSKLPVKWTAPEALKNKKFSTQSDVWSYGVLLWEIFSYGRQPYPKMTVNEVKECVEKGYRMDPPDECPADVYSIMTSCWQTEPKKRPSFHKLRERL 433
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: abl2 (c-abl oncogene 2, non-receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-020809-2]) HSP 1 Score: 280.026 bits (715), Expect = 2.460e-87 Identity = 151/395 (38.23%), Postives = 219/395 (55.44%), Query Frame = 1
Query: 22 SKYMLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG--IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR----ETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKN 1188
S Y+ N E H WYHGP++R AE LL G FL+RES + PG ++ + Y+ V HYRI + + E FS+L ELV + + A+GLVT L P PK P V + W R + ++ LG G + EV+ +K L D V +KEASVM V+H NLVQ G+ Y++TEYM +G+L++YLR + + + L + ++ M YLE+K+ +HRDLA RN L+ +N V K+ADFGL R +T + G + PIKWTAPE++ N FS SD+W+FGV+LWEI ++G PY GI + V +E+G+R+ P+ CPP++Y LM A W +P RP+F + H+ T+ + +
Sbjct: 117 SNYITPVNSLEKH----SWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTASDGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEASVMKEVKHPNLVQLLGVCTLEPPFYIVTEYMPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPLDRPSFAEIHQAFETMFHDSS 505
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: abl2 (c-abl oncogene 2, non-receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-020809-2]) HSP 1 Score: 278.1 bits (710), Expect = 9.843e-83 Identity = 151/392 (38.52%), Postives = 218/392 (55.61%), Query Frame = 1
Query: 22 SKYMLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG--IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR----ETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILN 1179
S Y+ N E H WYHGP++R AE LL G FL+RES + PG ++ + Y+ V HYRI + + E FS+L ELV + + A+GLVT L P PK P V + W R + ++ LG G + EV+ +K L D V +KEASVM V+H NLVQ G+ Y++TEYM +G+L++YLR + + + L + ++ M YLE+K+ +HRDLA RN L+ +N V K+ADFGL R +T + G + PIKWTAPE++ N FS SD+W+FGV+LWEI ++G PY GI + V +E+G+R+ P+ CPP++Y LM A W +P RP+F + H+ T+ +
Sbjct: 117 SNYITPVNSLEKH----SWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTASDGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEASVMKEVKHPNLVQLLGVCTLEPPFYIVTEYMPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPLDRPSFAEIHQAFETMFH 502
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: csk (C-terminal Src kinase [Source:NCBI gene;Acc:100216174]) HSP 1 Score: 351.288 bits (900), Expect = 5.473e-117 Identity = 170/377 (45.09%), Postives = 247/377 (65.52%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVI-DSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRIIY + +IDEEEYF +L +LVE Y +DA+GL T L KP G F ++GW L L +GKG+F +V ++G +A KC I++ + EA VMT ++H NLVQ G+++ D ++++TE+M GSLV+YLR+RG+S + L FS++V+ GM+YLE + VHRDLA RN+L+ + +AK++DFGL +E + + ++P+KWTAPEA+++ FS SD+WSFG++LWEIYSFG++PY I+++ V+ ++E G+++ P CPP +Y LM W ++P RP F+ + L I
Sbjct: 34 KSGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSG-KLSIDEEEYFENLMQLVEHYTNDADGLCTNLMKPKLVEGTV---AAQDEFSRSGWALKMRDLKLLHTIGKGEFGDVMLGEHQGVKVAVKC-IKNDATAQAFVAEAMVMTQLQHNNLVQLLGVIVEDKSGLFIVTEFMAKGSLVDYLRSRGRSVLGGECLLKFSLDVSEGMAYLESNNFVHRDLAARNVLVSEENIAKVSDFGLTKEASAIQDTSKLPVKWTAPEALRDKLFSTKSDVWSFGILLWEIYSFGRVPYPRIALKDVVPKVENGYKMDAPDGCPPVVYDLMKQCWHLDPKQRPTFRNLREQLEHI 405
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: csk (C-terminal Src kinase [Source:NCBI gene;Acc:100216174]) HSP 1 Score: 350.517 bits (898), Expect = 3.985e-116 Identity = 170/377 (45.09%), Postives = 247/377 (65.52%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVI-DSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRIIY + +IDEEEYF +L +LVE Y +DA+GL T L KP G F ++GW L L +GKG+F +V ++G +A KC I++ + EA VMT ++H NLVQ G+++ D ++++TE+M GSLV+YLR+RG+S + L FS++V+ GM+YLE + VHRDLA RN+L+ + +AK++DFGL +E + + ++P+KWTAPEA+++ FS SD+WSFG++LWEIYSFG++PY I+++ V+ ++E G+++ P CPP +Y LM W ++P RP F+ + L I
Sbjct: 78 KSGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSG-KLSIDEEEYFENLMQLVEHYTNDADGLCTNLMKPKLVEGTV---AAQDEFSRSGWALKMRDLKLLHTIGKGEFGDVMLGEHQGVKVAVKC-IKNDATAQAFVAEAMVMTQLQHNNLVQLLGVIVEDKSGLFIVTEFMAKGSLVDYLRSRGRSVLGGECLLKFSLDVSEGMAYLESNNFVHRDLAARNVLVSEENIAKVSDFGLTKEASAIQDTSKLPVKWTAPEALRDKLFSTKSDVWSFGILLWEIYSFGRVPYPRIALKDVVPKVENGYKMDAPDGCPPVVYDLMKQCWHLDPKQRPTFRNLREQLEHI 449
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: csk (C-terminal Src kinase [Source:NCBI gene;Acc:100216174]) HSP 1 Score: 346.665 bits (888), Expect = 1.006e-114 Identity = 170/379 (44.85%), Postives = 247/379 (65.17%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVI-DSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQ--FSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRIIY + +IDEEEYF +L +LVE Y +DA+GL T L KP G F ++GW L L +GKG+F +V ++G +A KC I++ + EA VMT ++H NLVQ G+++ D ++++TE+M GSLV+YLR+RG+S + L FS++V+ GM+YLE + VHRDLA RN+L+ + +AK++DFGL +E + + ++P+KWTAPEA+++ FS SD+WSFG++LWEIYSFG++PY I+++ V+ ++E G+++ P CPP +Y LM W ++P RP F+ + L I
Sbjct: 72 KSGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSG-KLSIDEEEYFENLMQLVEHYTNDADGLCTNLMKPKLVEGTV---AAQDEFSRSGWALKMRDLKLLHTIGKGEFGDVMLGEHQGVKVAVKC-IKNDATAQAFVAEAMVMTQLQHNNLVQLLGVIVEDKSGLFIVTEFMAKGSLVDYLRSRGRSVLGGECLLKFSLDVSEGMAYLESNNFVHRDLAARNVLVSEENIAKVSDFGLTKEASAIQDTSKLPVKWTAPEALRDKASLFSTKSDVWSFGILLWEIYSFGRVPYPRIALKDVVPKVENGYKMDAPDGCPPVVYDLMKQCWHLDPKQRPTFRNLREQLEHI 445
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: gpn2 (GPN-loop GTPase 2 [Source:Xenbase;Acc:XB-GENE-5751862]) HSP 1 Score: 323.939 bits (829), Expect = 4.546e-106 Identity = 161/378 (42.59%), Postives = 242/378 (64.02%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTIL 1176
K + L M W+HG IT A Q L P+E GLFL+RESV +PGD+ LCVC++D V HYRI ++ + ID + F++L +++E+Y + L T L KP K G+ +AGW+ L L + +G+G+F +V + Y G+ +A K + D+T + E + MT ++H+NLV G+++ + + L+ E M G+LVNYLR+RG+S + P L+FS+++ GM YLE K LVHRDLA RNIL+ + AKI+DFGL + + R+PIKWTAPEA++N +FS SD+WSFGV+LWE+YS+G+ PY +SV+ V+ +++G+R+ P+NCPP IYS+M + W +P RP FK+ + L T++
Sbjct: 64 KVDAKLSVMPWFHGAITGVQAVQQLQPKENGLFLVRESVRHPGDYVLCVCFKDEVTHYRI-SNQGGKLNIDLTQNFNNLMDMIEYYSAHQGVLTTRLIKPKCKQGMI---SAEQKLAKAGWLLNFQNLTLGKKIGEGEFGDVLQGEYMGRPVAIKNI--KCDMTAQNFLSETATMTKLQHKNLVNLLGVIL-KNGLLLVMELMSKGNLVNYLRSRGRSMVPPYQLLIFSMDIVQGMEYLELKRLVHRDLAARNILVSEKGEAKISDFGLSKPQLQQDDLSRLPIKWTAPEALQNYKFSSRSDVWSFGVLLWEVYSYGRAPYPKMSVREVIEAVKKGYRMEAPENCPPMIYSIMKSCWEADPGKRPTFKKLKEKLETMM 434
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: gpn2 (GPN-loop GTPase 2 [Source:Xenbase;Acc:XB-GENE-5751862]) HSP 1 Score: 322.013 bits (824), Expect = 7.618e-105 Identity = 164/397 (41.31%), Postives = 246/397 (61.96%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSSRC*CEFLFSI 1233
K + L M W+HG IT A Q L P+E GLFL+RESV +PGD+ LCVC++D V HYRI ++ + ID + F++L +++E+Y + L T L KP K G+ +AGW+ L L + +G+G+F +V + Y G+ +A K + D+T + E + MT ++H+NLV G+++ + + L+ E M G+LVNYLR+RG+S + P L+FS+++ GM YLE K LVHRDLA RNIL+ + AKI+DFGL + + R+PIKWTAPEA++N +FS SD+WSFGV+LWE+YS+G+ PY +SV+ V+ +++G+R+ P+NCPP IYS+M + W +P RP FK+ ++S R FLF++
Sbjct: 70 KVDAKLSVMPWFHGAITGVQAVQQLQPKENGLFLVRESVRHPGDYVLCVCFKDEVTHYRI-SNQGGKLNIDLTQNFNNLMDMIEYYSAHQGVLTTRLIKPKCKQGMI---SAEQKLAKAGWLLNFQNLTLGKKIGEGEFGDVLQGEYMGRPVAIKNI--KCDMTAQNFLSETATMTKLQHKNLVNLLGVIL-KNGLLLVMELMSKGNLVNYLRSRGRSMVPPYQLLIFSMDIVQGMEYLELKRLVHRDLAARNILVSEKGEAKISDFGLSKPQLQQDDLSRLPIKWTAPEALQNYKFSSRSDVWSFGVLLWEVYSYGRAPYPKMSVREVIEAVKKGYRMEAPENCPPMIYSIMKSCWEADPGKRPTFKK-------------QLMSPRATNPFLFTV 446
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Csk (c-src tyrosine kinase [Source:MGI Symbol;Acc:MGI:88537]) HSP 1 Score: 350.517 bits (898), Expect = 2.317e-116 Identity = 173/377 (45.89%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRI+Y + +IDEE YF +L +LVE Y +DA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Csk (c-src tyrosine kinase [Source:MGI Symbol;Acc:MGI:88537]) HSP 1 Score: 350.517 bits (898), Expect = 2.317e-116 Identity = 173/377 (45.89%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRI+Y + +IDEE YF +L +LVE Y +DA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Csk (c-src tyrosine kinase [Source:MGI Symbol;Acc:MGI:88537]) HSP 1 Score: 350.517 bits (898), Expect = 2.317e-116 Identity = 173/377 (45.89%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRI+Y + +IDEE YF +L +LVE Y +DA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Matk (megakaryocyte-associated tyrosine kinase [Source:MGI Symbol;Acc:MGI:99259]) HSP 1 Score: 304.679 bits (779), Expect = 2.755e-98 Identity = 153/375 (40.80%), Postives = 233/375 (62.13%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
L M W+HG I+ + A Q L P E+GLFL+RES +PGD+ LCV + V HYR+++ + TIDE F +L ++VE Y D + T L KP K G +AGW+ L L +G+G+F V + Y G+ +A K + D+T + E +VMT ++H+NLV+ G+++ +Y++ E++ G+LVN+LRTRG++ ++ L F+++VA GM YLE K LVHRDLA RNIL+ +++VAK++DFGL + R+P+KWTAPEA+KN +FS SD+WSFGV+LWE++S+G+ PY +S++ V +E+G+R+ P CP +++LM + W PA RP F++ + L L S
Sbjct: 75 LSLMPWFHGKISGQEAIQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDEAVCFCNLMDMVEHYTKDKGAICTKLVKPRRKQG---AKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--KCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPDGCPGSVHTLMGSCWEAEPARRPPFRKIVEKLGRELRS 442
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Matk (megakaryocyte-associated tyrosine kinase [Source:MGI Symbol;Acc:MGI:99259]) HSP 1 Score: 304.679 bits (779), Expect = 2.755e-98 Identity = 153/375 (40.80%), Postives = 233/375 (62.13%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
L M W+HG I+ + A Q L P E+GLFL+RES +PGD+ LCV + V HYR+++ + TIDE F +L ++VE Y D + T L KP K G +AGW+ L L +G+G+F V + Y G+ +A K + D+T + E +VMT ++H+NLV+ G+++ +Y++ E++ G+LVN+LRTRG++ ++ L F+++VA GM YLE K LVHRDLA RNIL+ +++VAK++DFGL + R+P+KWTAPEA+KN +FS SD+WSFGV+LWE++S+G+ PY +S++ V +E+G+R+ P CP +++LM + W PA RP F++ + L L S
Sbjct: 75 LSLMPWFHGKISGQEAIQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDEAVCFCNLMDMVEHYTKDKGAICTKLVKPRRKQG---AKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--KCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPDGCPGSVHTLMGSCWEAEPARRPPFRKIVEKLGRELRS 442
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P41239|CSK_CHICK (Tyrosine-protein kinase CSK OS=Gallus gallus OX=9031 GN=CSK PE=2 SV=1) HSP 1 Score: 356.295 bits (913), Expect = 8.882e-118 Identity = 172/377 (45.62%), Postives = 248/377 (65.78%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ + L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRIIY + +IDEE YF +L +LVE Y +DA+GL + L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ +AK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CP +Y +M W ++P HRP+F Q + L I
Sbjct: 72 KAGIKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSS-SKLSIDEEVYFENLMQLVEHYTTDADGLCSRLIKPKVMEGTV---AAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHI 443
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P41240|CSK_HUMAN (Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1) HSP 1 Score: 351.288 bits (900), Expect = 9.133e-116 Identity = 174/377 (46.15%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRI+Y + +IDEE YF +L +LVE Y SDA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP+F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P32577|CSK_RAT (Tyrosine-protein kinase CSK OS=Rattus norvegicus OX=10116 GN=Csk PE=1 SV=1) HSP 1 Score: 350.903 bits (899), Expect = 1.074e-115 Identity = 173/377 (45.89%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRI+Y + +IDEE YF +L +LVE Y +DA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P41241|CSK_MOUSE (Tyrosine-protein kinase CSK OS=Mus musculus OX=10090 GN=Csk PE=1 SV=2) HSP 1 Score: 350.517 bits (898), Expect = 1.621e-115 Identity = 173/377 (45.89%), Postives = 246/377 (65.25%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV + V+HYRI+Y + +IDEE YF +L +LVE Y +DA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV---AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHI 443
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q0VBZ0|CSK_BOVIN (Tyrosine-protein kinase CSK OS=Bos taurus OX=9913 GN=CSK PE=2 SV=1) HSP 1 Score: 350.132 bits (897), Expect = 2.242e-115 Identity = 174/377 (46.15%), Postives = 245/377 (64.99%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK-IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
K+ L M W+HG ITRE AE+LL P E GLFL+RES NYPGD+TLCV V+HYRI+Y + +IDEE YF +L +LVE Y SDA+GL T L KP G F ++GW L L + +GKG+F +V Y+G +A KC I++ + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ ++ VAK++DFGL +E S + G++P+KWTAPEA++ +FS SD+WSFG++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y +M W ++ A RP+F Q + L I
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLCPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTV---AAQDEFFRSGWALNMKDLKLLQTIGKGEFGDVMLGDYRGNKVAVKC-IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFLQLREQLERI 443
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A443RF52 (Tyrosine-protein kinase OS=Dinothrombium tinctorium OX=1965070 GN=B4U79_10615 PE=3 SV=1) HSP 1 Score: 404.445 bits (1038), Expect = 8.622e-135 Identity = 195/384 (50.78%), Postives = 264/384 (68.75%), Query Frame = 1
Query: 37 NTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEEC---LGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILN 1179
N ++EV L +M W+HG I RE AE LL PRE+GLFL+RES N+PGD+TLCVCY++ V+HYR+IY K + TIDEEE+F +L +LVE Y DA+GL T L +PK G + F++AGWV P LD +C LGKG+F +V A Y+G+ +A K +I SS + EAS+MT++RH+NLVQ G+V D I L+TEYM GSLV+YLR+RG+ +TP +Q+ F+I+ GM+YLE K +VHRDLA RN+L+ + VAK+ DFGL RE GG+ PIKWTAPEA+K ++FS SDMWSFG++LWEIYSFG++PY I + V+ +E+G+++ P CP EIY +M AW ++P RP+F K L + L
Sbjct: 13 NFKRAEVKLNAMPWFHGKIRREEAECLLQPREDGLFLVRESTNFPGDYTLCVCYKNKVEHYRVIY-KDNKLTIDEEEFFENLSQLVEHYQKDADGLCTRLRDSVPKRGGLEFSVDSKAFEKAGWVIPLADLDFGDCREVLGKGEFGDVRLAWYRGQKVAVKILIDSSKAAQSFLAEASLMTSLRHKNLVQLMGVVFDGGTICLVTEYMAKGSLVDYLRSRGRLHVTPRDQINFAIDTCAGMAYLESKHVVHRDLAARNVLISEECVAKVCDFGLAREESFNLEGGKFPIKWTAPEALKYHRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLVDVVKHVEKGYKMEAPDGCPSEIYEIMRQAWDLDPEARPSFAVVLKKLESFLK 395
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A1E1XQP7 (Tyrosine-protein kinase OS=Amblyomma sculptum OX=1581419 PE=2 SV=1) HSP 1 Score: 399.438 bits (1025), Expect = 2.632e-132 Identity = 194/386 (50.26%), Postives = 271/386 (70.21%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHY-FQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR-ETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI-LNSKNSI 1194
++EV L SM W+HG I+RE AE LL PRE+GLFL+RES NYPGD+TLCVC++ V+HYR+IY + + TIDEEEYF L +L+E Y DA+GL T L++ +PK G + + H F+ AGW + L + E +GKG+F +V A+YKG+ +A K + +S I EAS+MT++RH NLVQ GLVI+ + ++TEYM GSLV+YLR+RG+ +T ++Q+ F+ + GM+YLE K +VHRDLA RN+L+ + VAK++DFGL R E+D+ E GG+ PIKWTAPEA+K N+FS SDMWSFG++LWEIYSFG++PY I + V+ + +G+R+ P+ CP E+Y LM AAW P RP F Q + L + L ++N+I
Sbjct: 62 RAEVKLNSMPWFHGKISRERAEMLLQPREDGLFLVRESTNYPGDYTLCVCFRSKVEHYRVIY-RLGKLTIDEEEYFEGLPQLIEHYEQDADGLCTRLSRSVPKQGGEV--AIDHRAFEMAGWAIKKQDLQVIENIGKGEFGDVLLANYKGQKVAVKKIKESGKNML--IAEASLMTSLRHPNLVQLLGLVIEESSLQIVTEYMAKGSLVDYLRSRGRLHVTRLDQINFATDTCAGMAYLESKHVVHRDLAARNVLISDDCVAKVSDFGLARDESDNLE-GGKFPIKWTAPEALKCNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVRHVSKGYRMESPEGCPSEVYELMRAAWQEEPQERPTFAQVLRKLQGLRLEAQNAI 441
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: T1JDP9 (Tyrosine-protein kinase OS=Strigamia maritima OX=126957 PE=3 SV=1) HSP 1 Score: 398.667 bits (1023), Expect = 3.361e-132 Identity = 185/380 (48.68%), Postives = 258/380 (67.89%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
+SEV L +M W+HG I RE AE+LLHPR++GLFL+RES NYPGD+TLCVC+ V+HYR+IY K + TIDEEE+F +L +LVE Y DA+GL T L + +PK G + F+ AGWV + L L E +GKG+F +V + +G+ +A K + SS + EASVMT++RH NLVQ G+V D +YL+TE+M GSLV+YLR+RG+ +T +Q+ F+ + M+YLE K +VHRDLA RN+L+ AK++DFGL R+ + GG+ PIKWTAPEA+++++FS SDMWSFG++LWEIYSFG++PY I + V+ +E+G+R+ P+ CPPE+Y +M AW + P RP F K L + S
Sbjct: 49 KRSEVKLNAMPWFHGKIVRELAEELLHPRQDGLFLVRESTNYPGDYTLCVCFNQKVEHYRVIY-KDNKLTIDEEEFFENLTQLVEHYEKDADGLCTQLKRSVPKKGSLDFSVDSKAFEMAGWVINKSDLKLGEVIGKGEFGDVVLGNLRGQKVAVKTLKDSSKAAQQFLAEASVMTSLRHPNLVQMIGVVFDWPSVYLVTEFMGKGSLVDYLRSRGRLHVTKKDQINFACDTCAAMAYLESKKVVHRDLAARNVLISDEATAKVSDFGLARDESFNQEGGKFPIKWTAPEALRHSKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVQHVEKGYRMEAPEGCPPEVYEIMRKAWDLQPELRPTFSDVLKSLEHLRTS 427
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A087UEP1 (Tyrosine-protein kinase (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_19905 PE=3 SV=1) HSP 1 Score: 399.438 bits (1025), Expect = 3.861e-132 Identity = 186/376 (49.47%), Postives = 260/376 (69.15%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
+SEV L +M W+HG ITR+ AE LL PRE+GLFL+RES N+PGD+TLCVC+++ V+HYR+IY K+ + TIDEEEYF +L LVE Y +DA+GL T L +PK G P + F++AGW D L L E LGKG+F +V ++G+ +A K + +S + EASVMT++ H+NLVQ G+V + IY++TEYM GSLV+YLR+RG+ +T +Q+ F+ + GM+YLE + +VHRDLA RN+L+ VAK+ DFGL RE GG+ PIKWTAPEA+++++FS SDMWSFG++LWEIYSFG++PY I + V+ +E+G+R+ P+ CP EIY +M AW + P +RP F + K L +
Sbjct: 71 RSEVKLNAMPWFHGKITRDEAEALLQPREDGLFLVRESTNFPGDYTLCVCFKNKVEHYRVIY-KENKLTIDEEEYFENLSRLVEHYQNDADGLCTRLKLSVPKKGGPEFSVDSQEFEKAGWTIKLDDLKLGEVLGKGEFGDVVLGCFRGQKVAVKVLKDNSKAAQTFLAEASVMTSLSHRNLVQLLGVVFNWPSIYIVTEYMSKGSLVDYLRSRGRLHVTKQDQIHFATDTCAGMAYLESRQVVHRDLAARNVLISDENVAKVCDFGLAREKSFNLEGGKFPIKWTAPEALRHSKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEKGYRMEAPEGCPTEIYDIMKQAWDLEPENRPTFAEVLKRLEEL 445
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A2J7RIA3 (Tyrosine-protein kinase OS=Cryptotermes secundus OX=105785 GN=Csk PE=3 SV=1) HSP 1 Score: 397.512 bits (1020), Expect = 1.355e-131 Identity = 186/370 (50.27%), Postives = 259/370 (70.00%), Query Frame = 1
Query: 43 NKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDK--IYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFK 1146
K+EV L +M W+HG I+R+ AEQLL P+E+GLFL+RES N+PGD+TLCVCYQ V+HYR+ Y K + TID+EE+F +L +LVE Y DA+GL T LTK LPK G + F +AGWV L+L E +GKG+F +V +G +A K + SS+ + EAS+MT++RH+NLVQ GLV ++ IYL+TEYM GSLV+YLR+RG+ +T +Q+ F+ + GM YLE + +VHRDLA RN+L+ + VAK++DFGL RE + GG++PIKWTAPEA+K ++FS SDMWSFG++LWEIYSFG++PY I + V+ +E+G+++ P+ CPPE+Y +M AW + P RP F+
Sbjct: 55 KKAEVKLNAMPWFHGKISRDRAEQLLSPKEDGLFLVRESTNFPGDYTLCVCYQGKVEHYRVKY-KDNQLTIDDEEFFENLSQLVEHYEQDADGLCTQLTKSLPKKGKQDFCVDTKAFVEAGWVIQEHELELRESIGKGEFGDVMLGILRGDKVAVKMLKDSSEAAQKFLAEASLMTSLRHENLVQLLGLVFNNKNKHIYLVTEYMSKGSLVDYLRSRGRLHVTKKDQINFAFDTCSGMEYLESRKVVHRDLAARNVLISEEGVAKVSDFGLAREENFTLEGGKLPIKWTAPEALKQSKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEKGYKMEAPEGCPPEVYEIMRQAWDLQPDKRPTFR 423
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: csk (tyrosine-protein kinase CSK [Source:NCBI gene;Acc:103033740]) HSP 1 Score: 348.206 bits (892), Expect = 1.276e-115 Identity = 169/377 (44.83%), Postives = 241/377 (63.93%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSD-KIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITRE AE+LL+P E GLFL+RES N+PGD+TLCV V+HYRI+Y + + +IDEEE+F +L +LVE Y DA+GL T L KP G F ++GW R L L + +GKG+F +V Y+G +A KC+ + + EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG++ I L FS+NV M YLE + VHRDLA RN+L+ + +AK++DFGL +E S + ++P+KWTAPEA++ FS SD+WS+G++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y++M W ++ RP F L I
Sbjct: 72 KSGGKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNFPGDYTLCVSCDGKVEHYRIVY-QNCKLSIDEEEFFENLMQLVEHYTKDADGLCTRLIKPKLMEGTV---AAQDEFSRSGWALNRKELKLLQAIGKGEFGDVMVGDYRGTKVAVKCIKHDATAQAF-VAEASVMTQMRHNNLVQLLGVIVEEKGSLYIVTEYMAKGSLVDYLRSRGRTIIGGDCLLKFSMNVCEAMEYLEANNFVHRDLAARNVLVSDDNIAKVSDFGLTKEASSTQDTAKLPVKWTAPEALREKTFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYNIMKQCWTLDVNMRPTFNALRDSLQDI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: CSK (C-terminal Src kinase [Source:NCBI gene;Acc:103023502]) HSP 1 Score: 344.739 bits (883), Expect = 3.037e-114 Identity = 167/377 (44.30%), Postives = 244/377 (64.72%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDS-DKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITR+ AE+LL+P E GL+L+RES NYPGD+TLCV + V+HYRIIY + +IDEEE+F +L +LVE Y DA+GL T L KP G F ++GW R L L + +GKG+F +V Y+G +A KC+ + I EASVMT +RH NLVQ G++++ ++++TEYM GSLV+YLR+RG++ + L FS++V M YLE + VHRDLA RN+L+ ++ +AK++DFGL +E S + ++P+KWT+PEA++ +FS SD+WS+GV+LWEIYSFG++PY I ++ V+ +E+G+++ P CP +Y LM W ++ RP+F+ + L I
Sbjct: 72 KSGGKLSLMPWFHGKITRDQAERLLYPPETGLYLVRESTNYPGDYTLCVSCEGKVEHYRIIY-HNGKLSIDEEEFFENLMQLVEHYTKDADGLCTRLIKPKLMEGTV---AAQDEFSRSGWALSRKDLKLIQTIGKGEFGDVMVGDYRGTKVAVKCIKHDATAQAF-IAEASVMTQLRHNNLVQLLGVIVEERGSLFIVTEYMAKGSLVDYLRSRGRTVLGGDCLLKFSLDVCEAMEYLEVNNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTAKLPVKWTSPEALREKRFSTKSDVWSYGVLLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDAPDGCPAVVYDLMKQCWTLDSVMRPSFRMLREKLQHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: CSK (C-terminal Src kinase [Source:NCBI gene;Acc:103023502]) HSP 1 Score: 344.739 bits (883), Expect = 3.598e-114 Identity = 167/377 (44.30%), Postives = 244/377 (64.72%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDS-DKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITR+ AE+LL+P E GL+L+RES NYPGD+TLCV + V+HYRIIY + +IDEEE+F +L +LVE Y DA+GL T L KP G F ++GW R L L + +GKG+F +V Y+G +A KC+ + I EASVMT +RH NLVQ G++++ ++++TEYM GSLV+YLR+RG++ + L FS++V M YLE + VHRDLA RN+L+ ++ +AK++DFGL +E S + ++P+KWT+PEA++ +FS SD+WS+GV+LWEIYSFG++PY I ++ V+ +E+G+++ P CP +Y LM W ++ RP+F+ + L I
Sbjct: 75 KSGGKLSLMPWFHGKITRDQAERLLYPPETGLYLVRESTNYPGDYTLCVSCEGKVEHYRIIY-HNGKLSIDEEEFFENLMQLVEHYTKDADGLCTRLIKPKLMEGTV---AAQDEFSRSGWALSRKDLKLIQTIGKGEFGDVMVGDYRGTKVAVKCIKHDATAQAF-IAEASVMTQLRHNNLVQLLGVIVEERGSLFIVTEYMAKGSLVDYLRSRGRTVLGGDCLLKFSLDVCEAMEYLEVNNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTAKLPVKWTSPEALREKRFSTKSDVWSYGVLLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDAPDGCPAVVYDLMKQCWTLDSVMRPSFRMLREKLQHI 446
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:NCBI gene;Acc:103034670]) HSP 1 Score: 328.561 bits (841), Expect = 2.938e-108 Identity = 164/385 (42.60%), Postives = 246/385 (63.90%), Query Frame = 1
Query: 58 HLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLT---FVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSS 1203
+L M W+HG I+ A L P E+GLFL+RES+ +PGD+ LCV ++ V HYR+IY + + TID ++F +L ++VEFY + LVT L KP K G ++ + GW+ GL L E +G+G+F V++ Y G+ +A K + SD+T F+G E SVMT ++H+NLVQ G+++ + +Y++TE+M G+LVNYLR+RG+S I+ + L +++ V GM YLE K LVHRDLA RNILL ++ VAK++DFGL + ++P+KWTAPE +KN + S SD+WS+GV+LWEI+S+G PY +S+Q V ++EQG+R+ P+ CPPE+Y++M W P RP+F + ++L + S S
Sbjct: 49 NLSLMPWFHGKISGPEAVSKLRPMEDGLFLVRESIRHPGDYVLCVSFKQEVIHYRVIY-QDSKLTIDSTQHFYNLIDMVEFYSKNKGALVTTLQKPKQKEGARSAALQLY---KTGWLLDLAGLTLGESIGEGEFGAVYEGEYMGRKVAVKNI--KSDVTAQAFLG--ETSVMTKLQHKNLVQLLGVILH-NGLYIVTEFMAKGNLVNYLRSRGRSVISTVQLLHYALEVCEGMEYLECKKLVHRDLAARNILLSEDNVAKVSDFGLAKVDSQAFDNTKLPVKWTAPEGLKNKKISTRSDVWSYGVLLWEIFSYGMQPYPKMSLQEVKEQVEQGYRMEAPEACPPEVYTIMRDCWEKEPKMRPSFHKLRELLQAEVTKHESSTGS 424
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:NCBI gene;Acc:103034670]) HSP 1 Score: 328.561 bits (841), Expect = 7.092e-108 Identity = 164/385 (42.60%), Postives = 246/385 (63.90%), Query Frame = 1
Query: 58 HLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLT---FVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSS 1203
+L M W+HG I+ A L P E+GLFL+RES+ +PGD+ LCV ++ V HYR+IY + + TID ++F +L ++VEFY + LVT L KP K G ++ + GW+ GL L E +G+G+F V++ Y G+ +A K + SD+T F+G E SVMT ++H+NLVQ G+++ + +Y++TE+M G+LVNYLR+RG+S I+ + L +++ V GM YLE K LVHRDLA RNILL ++ VAK++DFGL + ++P+KWTAPE +KN + S SD+WS+GV+LWEI+S+G PY +S+Q V ++EQG+R+ P+ CPPE+Y++M W P RP+F + ++L + S S
Sbjct: 76 NLSLMPWFHGKISGPEAVSKLRPMEDGLFLVRESIRHPGDYVLCVSFKQEVIHYRVIY-QDSKLTIDSTQHFYNLIDMVEFYSKNKGALVTTLQKPKQKEGARSAALQLY---KTGWLLDLAGLTLGESIGEGEFGAVYEGEYMGRKVAVKNI--KSDVTAQAFLG--ETSVMTKLQHKNLVQLLGVILH-NGLYIVTEFMAKGNLVNYLRSRGRSVISTVQLLHYALEVCEGMEYLECKKLVHRDLAARNILLSEDNVAKVSDFGLAKVDSQAFDNTKLPVKWTAPEGLKNKKISTRSDVWSYGVLLWEIFSYGMQPYPKMSLQEVKEQVEQGYRMEAPEACPPEVYTIMRDCWEKEPKMRPSFHKLRELLQAEVTKHESSTGS 451
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: abl1 (c-abl oncogene 1, non-receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-100812-9]) HSP 1 Score: 264.233 bits (674), Expect = 1.022e-78 Identity = 143/394 (36.29%), Postives = 218/394 (55.33%), Query Frame = 1
Query: 22 SKYMLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYK--GKILAAKCVIQSSDLTFVG--IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR----ETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILN 1179
S Y+ N E H WYHGPI+R AE LL G FL+RES + PG ++ + + V HYRI +Y + E FS+L ELV + S A+GL+ L P PK P V + + W R + ++ LG G + EV++ K + +A K + D V +KEA++M ++H NLVQ G+ Y++TE+M +G+L++YLR + +T + L + ++ M YLE+K+ +HRDLA RN L+ ++ + K+ADFGL R +T + G + PIKWTAPE++ N+F +FGV+LWEI ++G PY G+ + V +E+G+R+ P+ CPP +Y LM A W N A RP+F + H+ T+ +
Sbjct: 88 SNYITPVNSLEKH----SWYHGPISRNAAEYLLSSGINGSFLLRESESSPGQLSISLRCEGRVYHYRINTASDGKYFVSSESRFSTLAELVHHHSSVADGLIVPLHYPAPKRTKPTVYGVSPTYDR--WEIERTDITMKHKLGGGQYGEVYEGLKKKYSRTVAVKTLNPREDTMEVEEFLKEAAMMKEIKHPNLVQLLGVCTREPPFYIVTEFMTHGNLLDYLRECNRDEVTAVVLLHMATQISSAMEYLEKKNFIHRDLAARNCLVAESHMVKVADFGLSRLMTGDTYTARAGAKFPIKWTAPESLAYNKFCAPVSCSAFGVLLWEIATYGMSPYPGVDLSQVYERLERGYRMEQPEGCPPRVYQLMQACWQWNAADRPSFAEIHQTFETMFH 475
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 244.588 bits (623), Expect = 8.563e-77 Identity = 139/373 (37.27%), Postives = 212/373 (56.84%), Query Frame = 1
Query: 76 WYHGPITRETAEQLLHPR--EEGLFLIRESVNYPGDFTLCVCYQDGVQ-----HYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAG---WVFPRDGLDLEECLGKGDFAEVFKAHY-KGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR--ETDSY--ELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQ 1149
W+ G I+R A +LL R + G FLIRES + G + L V D +Q HY I + +TI++ FS+L++LV ++ +ANGL K L + PV W R ++L LG G F EV++ + K +A K + + + + EA +M H NL+Q + + + IY++TE M+NGSL+ YL+ + + + ++ VA GM+YLE ++ +HRDLA RNIL+ N+ K+ADFGL R + D Y GG+ P+KWTAPEA ++F+ SD+WSFG++L+EI ++GK+PY+G++ V+ E+E G+R+PCP NCP + YS+M W A RP+F Q
Sbjct: 1 WFFGKISRADAVKLLLARGNDHGSFLIRESESKHGAYALSVSEWDALQGVEVRHYHIQPLEGGGFTINKRAAFSTLQDLVRHHVLEANGL-----KSLILYVCMVTSPVTFGLSHDTVDQWEVKRSSIELLRQLGAGQFGEVYEGLWNKTTRVAVKTLKPGAMVPEEFLAEAHIMKRFTHCNLIQLYAVCTTEEPIYIITELMVNGSLLQYLQNDEGGVLKMCHLINMAVQVASGMAYLEAQNYIHRDLAARNILVGDNLTCKVADFGLARVIKDDEYIAREGGKFPVKWTAPEAANYSRFTIKSDVWSFGILLYEIVTYGKVPYAGMTNAEVLEELEHGYRMPCPTNCPRDFYSIMYNCWHKEEACRPSFLQ 368
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006670.1 (pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene:ENSPMAG00000006016.1 transcript:ENSPMAT00000006670.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 243.817 bits (621), Expect = 1.585e-76 Identity = 132/345 (38.26%), Postives = 196/345 (56.81%), Query Frame = 1
Query: 136 GLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHY-KGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR-----ETDSYE--LGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFK 1146
G FL+R+S ++L V D V+HY+I +K + I F++L +LV+ Y DANGL L +P K +P + W PR + L + LG G F EV++ + K +A K + Q + ++EA +M +RH L+Q + + + IY++TE M NGSL NYL+T + + + + VA GM+YLE ++ +HRDLA RNIL+ ++ K+ADFGL R D YE +G + PIKWTAPEA N+FS SD+WSFGV+L EI ++GKLPY G + V++ +++G+R+PCP CP Y LM W ++ RP F+
Sbjct: 18 GSFLVRQSETSGHGYSLSVRDGDTVKHYKIRVLEKGSFFITRRNQFATLRDLVQSYSRDANGLCVTLNQPCLKKEMPQTEGLSSDMADK-WEIPRSSVQLVKRLGAGQFGEVWQGLWNKTTPVAIKTLKQGTMDRDDFLREAQLMKRLRHPKLIQLYAVCTQEEPIYIITELMSNGSLANYLQTPEGRSLDLVELVDMAAQVAAGMAYLEAQNYIHRDLAARNILVAEHNACKVADFGLARVIKMSNEDEYEARVGSKFPIKWTAPEAANYNRFSIKSDVWSFGVLLHEIITYGKLPYPGQTNAEVLAAVDRGYRMPCPPGCPQAFYDLMLECWNVDDQARPTFE 361
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 242.276 bits (617), Expect = 4.108e-75 Identity = 139/378 (36.77%), Postives = 211/378 (55.82%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQ--LLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRII-YDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPV---IHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLT---FVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR-----ETDSYE--LGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFK 1146
L + W+ G I R AE+ L G FLIR+S + D++L V V+HYRI D+ + I F +L ELV++Y S+++GL L KP + I P + Y W PR + L++ LG G F EV++ + L A ++ + F+G EA +M +RH NL+Q + + + IY++TE M +GSL++YLR + + + +A GM+YLE ++ +HRDLA RNIL+ + V K+ADFGL R D YE G +VPIKWTAPEAV ++FS SD+WSFG++L+E+ ++G++PY + V+ ++++G+R+P P NCPP YS+M W RP F+
Sbjct: 65 LDAEPWFFGDIKRADAEKYLLADVNTTGAFLIRQSESRKTDYSLSVRDGSTVKHYRIRQLDENGGFFISRRVTFQNLIELVQYYKSNSDGLCMALQKPC----VVIEAPTTIGLSYNTVDKWEIPRASIQLQKRLGAGMFGEVWQGLWNNSTLVAVKTLKPGAMKKEEFIG--EAQIMKQLRHANLIQLYAVCSQEEPIYIITELMRHGSLLDYLRGPLGKQLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDNCPPLFYSIMLECWNKKEEERPTFE 436
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72]) HSP 1 Score: 241.891 bits (616), Expect = 1.953e-74 Identity = 141/375 (37.60%), Postives = 215/375 (57.33%), Query Frame = 1
Query: 76 WYHGPITRETAEQ--LLHPREEGLFLIRESVNYPGDFTLCVCYQ-----DGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKI-LAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR--ETDSYEL--GGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVL 1164
W+ ++R+ AE+ LL + G +LIR+S G ++L V D V+HY+I K Y I F +L+ELV +Y A+GL L KP + I P +++ W PR+ + LE+ LG G F +V+ Y K +A K + S ++EA++M T++H LV+ H +V D + I+++TEYM GSL+++L+T S + + VA GM+++E K+ +HRDL NIL++ N+V KIADFGL R E + Y G + PIKWTAPEA+ FS SD+WSFG++L E+ +FG++PY G++ V+ +E+G+R+P P NCP E+YS+M W P RP F+ +L
Sbjct: 129 WFFKGLSRKDAERQLLLCGNKIGSYLIRDSETNKGSYSLSVRDHIVEVGDTVKHYKIRTLDKGGYFITSRITFHTLQELVVYYHLKADGLCQKLGKPC----IAIQPQ--KPWEKDAWEIPRESIKLEKKLGAGQFGDVWMGVYNKKTKVAVKMMKPGSMAPQAFLEEANLMKTLQHDKLVRLHAVVTD-EPIFIVTEYMEKGSLLDFLKTSEGSRLKQPKMIDMCAQVAEGMAFIEDKNYIHRDLRAANILVNVNLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEMVTFGRIPYPGMTNPEVIRSLERGYRMPKPDNCPCELYSIMQECWRQKPEERPTFEYLQSLL 496
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 112.849 bits (281), Expect = 6.435e-27 Identity = 70/245 (28.57%), Postives = 122/245 (49.80%), Query Frame = 1
Query: 433 LEECLGKGDFAEVFKA--HYKGKILAAKCVIQSSDLTFVGI-KEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHK 1158
L++ +G+G + V+KA + +++A K V+ +D I E S++ + H N+V++HG + S ++Y+L EY NGSL L +R +G++ + G+ YL + ++HRD+ NILL + K+ADFG+ +S L + W APE + N S +SD+WS G + E+ + PY ++ ++ +E P P + + + +V N RP Q K
Sbjct: 27 LKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSL-RRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNP-PYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLSKCFVKNMYKRPTADQLLK 268
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 106.301 bits (264), Expect = 9.969e-25 Identity = 79/254 (31.10%), Postives = 130/254 (51.18%), Query Frame = 1
Query: 439 ECLGKGDFAEVFKAH--YKGKILAAKCV----IQSSDLTFVGIKEA-----SVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRET-DSY---ELGGRVPIKWTAPEAVKNNQ-FSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRL-PCPQNCPPEIYSL----MDAAWVINPAHRP 1137
E +GKG F V+ G+++A K V S + + EA S + + H N+VQ+ G ++ L EY+ GS+ + +R G+ I L + V G++YL K ++HRD+ N+LLD++ + KI+DFG+ R++ D Y ++ R + W APE V Q +S D+WS G ++ E+++ GK P+S + V M +I + P P++ P I + +DA + INP RP
Sbjct: 1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHL--TTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRP 1429
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 93.5893 bits (231), Expect = 1.240e-20 Identity = 65/206 (31.55%), Postives = 108/206 (52.43%), Query Frame = 1
Query: 547 IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDS----YELGGRVPIKWTAPEAVKNNQFS-PMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQ 1149
I+EAS+ + H ++ + + S+ Y+L EY+ G L++Y+ G I F+ +A + YL ++VHRDL NI++ + KI DFGL DS + G + + APE +K N ++ P D+WSFGVVL+ + GK+P+ + + +I+QG ++ PQ+ E+ SL+ V++P R KQ
Sbjct: 192 IREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHG--SIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGS--LYFAAPELLKANPYTGPEVDVWSFGVVLF-VLVCGKVPFDDENSSVLHEKIKQG-KVEYPQHLSIEVISLLSKMLVVDPKRRATLKQ 391
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 91.2781 bits (225), Expect = 5.630e-20 Identity = 73/248 (29.44%), Postives = 113/248 (45.56%), Query Frame = 1
Query: 445 LGKGDFAEVFK-AHYKGKILAAKCV----IQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLC-----RETDSYELGGRVPIKWTAPEAV--KNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIE-QGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQ 1149
LG+G FA F+ G+I AAK V I+S + E + ++ H N+VQF D +Y+L E NGSL+ L+ R +T F+ + + Y+ + ++HRDL NI D N KI DFGL Y + G P + APE + K++ S D+WS GV+L+ + GK P+ V + I+ + F P + E L+ ++P RP+ +
Sbjct: 88 LGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRR--KVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICG-TP-NYIAPEVLMGKHSGHSFEVDIWSLGVMLYALL-IGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTE 330
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 88.9669 bits (219), Expect = 1.091e-19 Identity = 59/218 (27.06%), Postives = 110/218 (50.46%), Query Frame = 1
Query: 376 PVIHYFQQAGWVFPRDGLDLEECLGKGDFAEV--FKAHYKGKILAAKCVIQSSDLTFVGIK----EASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETD--SYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPY 1005
P++ Y +G + + LG G F V ++++ G+ A K + + + + ++ E +++ V H +++ G DS +++++ +Y+ G L + LR + + P+ + ++ V + YL KD+++RDL NILLDKN KI DFG + +Y L G + APE V ++ D WSFGV+++E+ + G P+
Sbjct: 72 PMLQYRDTSG-KYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLR-KSQRFPNPVAKF-YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTP--DYIAPEVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPF 283
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18]) HSP 1 Score: 230.72 bits (587), Expect = 1.946e-72 Identity = 109/267 (40.82%), Postives = 164/267 (61.42%), Query Frame = 1
Query: 406 WVFPRDGLDLEECLGKGDFAEVFKAHYK--GKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR--ETDSYEL--GGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKN 1188
W R + ++ LG G + EV++ +K K +A K + + + +KEASVM ++HQNLVQ G+ Y++TE+M+NG+L++YLR+ + + + + V MSYLE + +HRDLA RN L+ N + K+ADFGL R D Y G + PIKWTAPEA+ +N FS SD+W+FG++LWE+ ++G PY GI + V +++ G+R+PCP+ CPPE+YSLM W +P RP+FK+ H+ L T+ S N
Sbjct: 7 WEIERTEIAMKHKLGGGQYGEVYEGTWKKYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSN 273
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO35408 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ9]) HSP 1 Score: 186.422 bits (472), Expect = 1.262e-55 Identity = 96/281 (34.16%), Postives = 157/281 (55.87%), Query Frame = 1
Query: 406 WVFPRDGLDLEECLGKGDFAEVFKAHYK-------GKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGK---------SGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSY-------ELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILN 1179
W PRD + L + +G+G F VF K I K V D+ + ++ + H N+V G +Y++TEY+ G+L++ LR + S +T + L +++V+ GM ++ K VHRDLA RN+L+ + AK+ADFGL R D Y GGR+PIKW APEA+++ ++ +D+WSFGV+LWEI + G+ PY G+ + ++ ++ G+++PCP +C E+YS+M++ W + P+ RP F + K+LT +L+
Sbjct: 4 WEIPRDCVTLGDRIGEGQFGIVFAGTVKIGEDTIKAAIKCIKDVDDRYDMKDLKLEMEMMKEIGYHPNVVSLIGTCTIETPLYIITEYVSGGNLLDQLRQSRRTDSKYVNVNSTLTSRDLLRIALDVSRGMRHIAMKKFVHRDLAARNVLMTDTLTAKVADFGLAR--DIYCEGKYVKTGGGRLPIKWMAPEAIRDQVYTTQTDVWSFGVLLWEIVTLGRSPYPGVPIAMLLEKLLYGYKMPCPSHCSEEVYSVMESCWQLEPSARPGFGELSKILTEMLS 282
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8]) HSP 1 Score: 189.119 bits (479), Expect = 4.477e-55 Identity = 103/262 (39.31%), Postives = 157/262 (59.92%), Query Frame = 1
Query: 427 LDLEECLGKGDFAEVFKAHYKGK-----ILAAKCVIQSSDLTFVG--IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETD--SYEL-GGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
L LE+ +G G+F +V+K K +A K + Q S G + EASVM N++ G+V + + ++TE+M NGSL N+L+ + S ++ I + + +A GM YL + + VHRDLA RNIL+ + +V K+ADFGL RE + +YE GG++P++WTAPEA+K +FS SD+WS+G++LWE +SF + PY S VM +E G+RLP P +CP I+ +M W + RP+F K L +++ S
Sbjct: 58 LKLEKVIGGGEFGDVYKGTLKRPGENTIPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKTHPLMIVTEFMSNGSLDNFLK-KMDSKLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSRELEDSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPPMSCPKVIHQIMLECWDADRTKRPSFALIVKQLDSLIRS 318
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO37886 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEI8]) HSP 1 Score: 182.57 bits (462), Expect = 5.844e-54 Identity = 102/295 (34.58%), Postives = 159/295 (53.90%), Query Frame = 1
Query: 400 AGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIK----------------EASVMTTV-RHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRG--------------KSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRE---TDSY--ELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTIL 1176
A W FP L L+E LG G F +V KA G IL+ ++S+ T V +K E +M + H+N++ G + + L+ EY +G+L+ +LRTR K+ T +Q++ + +A GM +L K +HRDLA RN+L+D+ KI DFGL R+ TD Y + G +P+KW APEA+ + ++S +D+W+FGVVLWEI + G PY G+ ++ ++ I +G R+ P++CPPEIY++M W + RP F + + + IL
Sbjct: 6 ADWEFPEKRLILQEVLGSGAFGQVIKAEAIG-ILSLSARDKTSEATTVAVKMLKENASESDYKDLASELKIMIHLGEHKNIINLLGACTRGENLMLILEYAKHGNLLQFLRTRRDIYEPTWKKTTFNPKTEFTLADQVVDAYQIAQGMDFLASKKCIHRDLAARNVLVDEGYALKIGDFGLARDIYKTDLYVKKGAGLLPVKWMAPEALFDREYSSKTDVWAFGVVLWEILTLGGSPYPGVPLEQLLDYINEGKRMAQPRDCPPEIYAIMCDCWSLEQDRRPTFAELVRRIERIL 299
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7]) HSP 1 Score: 184.496 bits (467), Expect = 1.683e-53 Identity = 98/278 (35.25%), Postives = 154/278 (55.40%), Query Frame = 1
Query: 418 RDGLDLEECLGKGDFAEVFKAHYKG----------KILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDS--------YEL-GGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSI 1194
+D L LE +G G+FA+V++ KIL ++ + V EAS+M H N++ G++ + + ++TE++ NGSL N+L++ +T + + VA GM+YL + + +HRDLA RNIL+ N+ AK++DFGL RE D Y+ GG++P++WTAPEA++ +FS SD+WS+G++LWEI SFG+ PY VM +E G+RLP P CP I++LM W RP F + ++ S + +
Sbjct: 24 KDDLKLEIIIGGGEFADVYRGVLTNEDKTQEKVAVKILKPGSSHKNREDFCV---EASIMGQFDHPNVIALKGVITRTRPMMIITEFLENGSLDNFLKS-NDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAPMKCPKVIHNLMLDCWDKEKTSRPKFADIVRRFDEVIRSPDKM 297
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: CSK (C-terminal Src kinase [Source:NCBI gene;Acc:101160398]) HSP 1 Score: 353.599 bits (906), Expect = 1.031e-118 Identity = 171/368 (46.47%), Postives = 242/368 (65.76%), Query Frame = 1
Query: 73 VWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDS-DKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
+W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRIIY + TIDEEEYF +L +LVE Y DA+GL T L KP G F ++GW R L L + +GKG+F +V Y+G +A KC I++ I EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ + +AK++DFGL +E S + ++P+KWT+PEA++ +FS SD+WS+G++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y LM W ++ A RP+F+ + L I
Sbjct: 1 IWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIIY-HNGKLTIDEEEYFENLMQLVEHYTKDADGLCTRLIKPKLMEGTV---AAQDEFSRSGWALNRKELKLLQTIGKGEFGDVILGDYRGTRVAVKC-IKNDATAQAFIAEASVMTQLRHNNLVQLLGVIVEERGSLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSDDNIAKVSDFGLTKEASSIQDTAKLPVKWTSPEALREKRFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPVVYDLMKQCWTLDAAMRPSFRMLREKLQHI 363
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: CSK (C-terminal Src kinase [Source:NCBI gene;Acc:101160398]) HSP 1 Score: 355.525 bits (911), Expect = 1.740e-118 Identity = 175/377 (46.42%), Postives = 245/377 (64.99%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDS-DKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTI 1173
KS L M W+HG ITRE AE+LL+P E GLFL+RES NYPGD+TLCV V+HYRIIY + TIDEEEYF +L +LVE Y DA+GL T L KP G F ++GW R L L + +GKG+F +V Y+G +A KC I++ I EASVMT +RH NLVQ G++++ +Y++TEYM GSLV+YLR+RG+S + L FS++V M YLE + VHRDLA RN+L+ + +AK++DFGL +E S + ++P+KWT+PEA++ +FS SD+WS+G++LWEIYSFG++PY I ++ V+ +E+G+++ P CPP +Y LM W ++ A RP+F+ + L I
Sbjct: 72 KSGGKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIIY-HNGKLTIDEEEYFENLMQLVEHYTKDADGLCTRLIKPKLMEGTV---AAQDEFSRSGWALNRKELKLLQTIGKGEFGDVILGDYRGTRVAVKC-IKNDATAQAFIAEASVMTQLRHNNLVQLLGVIVEERGSLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSDDNIAKVSDFGLTKEASSIQDTAKLPVKWTSPEALREKRFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPVVYDLMKQCWTLDAAMRPSFRMLREKLQHI 443
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: ENSORLT00000006131.2 (tyrosine-protein kinase CSK [Source:NCBI gene;Acc:101158271]) HSP 1 Score: 350.903 bits (899), Expect = 1.255e-116 Identity = 169/381 (44.36%), Postives = 250/381 (65.62%), Query Frame = 1
Query: 46 KSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSD-KIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSK 1185
K++ L M W+HG ITR+ AE+LL+P E GLFL+RES N+PGD+TLCV V+HYRIIY + TIDEE YF +L +L+E Y DA+GL T L KP + G F ++GW R L L++ +GKG+F +V Y+G +A KC I++ I EASVMT +RH NLVQ G++++ + +Y++TEYM G LV+YLR+RG++ + L F+I+V M+YLE + VHRDLA RN+L+ + +AK++DFGL +E S + ++P+KWTAPEA++ FS SD+WS+G++LWEIYSFG++PY I ++ V+ +E+G+++ CP CP +Y++M W ++P RP+F+ + L I + K
Sbjct: 72 KTDGKLSLMPWFHGKITRDQAERLLNPPETGLFLVRESTNFPGDYTLCVSCDGKVEHYRIIY-HNGKLTIDEEVYFENLMQLMEHYTKDADGLCTKLIKPKLEEGTV---AAQDEFSRSGWSMNRKDLKLQQVIGKGEFGDVMVGDYRGTKVAVKC-IKNDATAQAFIAEASVMTQMRHNNLVQLLGVIVEENGSLYIVTEYMAKGCLVDYLRSRGRTVLGGEALLKFAIDVCEAMAYLETNNFVHRDLAARNVLVSDDNIAKVSDFGLTKEASSTQDTAKLPVKWTAPEALREKNFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDCPDGCPEVVYNIMKQCWNLDPGARPSFQMLKEWLHHISHKK 447
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: matk (megakaryocyte-associated tyrosine kinase [Source:NCBI gene;Acc:101164299]) HSP 1 Score: 303.138 bits (775), Expect = 5.634e-98 Identity = 154/383 (40.21%), Postives = 239/383 (62.40%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSSR 1206
L M W+HG I+ A L P E+GLFL+RESV +PGD+ LCV + V HYR+IY + + TID ++YF +L +++EFY + + + T LTKP K G + GW+ L L +G+G+F V++ Y G+ +A K + D+T ++E +VMT ++H+NLV+ G++++ ++++TE M+ G+LVN+LRTRG+S +T I +S++V GM YLE K LVHRDLA RNIL+ + AKI+DFGL + ++PIKWTAPEA+ +FS SD+WS+GV+LWEI+S+G+ PY +S++ V +++E G+R+ P++CP +YSLM W P RP F + + L + ++ L ++
Sbjct: 73 LSLMPWFHGKISGSEAVCQLQPAEDGLFLVRESVRHPGDYVLCVSFSGEVIHYRVIY-QDNKLTIDNKQYFYNLIDMIEFYSKNKDSIATTLTKPKQKQGTK---SAELELSKMGWLLDMTKLRLGGIIGEGEFGAVYEGEYVGQRVAVKTI--KCDVTAQAFLQETAVMTKLQHKNLVRLLGVILNKG-LHIVTELMIKGNLVNFLRTRGRSVVTSIQLFRYSLDVCEGMEYLESKKLVHRDLAARNILVSDDNAAKISDFGLTKVVSKEADKAKLPIKWTAPEALTKEKFSTKSDVWSYGVLLWEIFSYGRQPYPKMSLKDVQAKVEAGYRMEAPEDCPANVYSLMKLCWEQEPRRRPGFPKLREKLEREMGKRSPGLPAK 448
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: matk (megakaryocyte-associated tyrosine kinase [Source:NCBI gene;Acc:101164299]) HSP 1 Score: 303.138 bits (775), Expect = 5.634e-98 Identity = 154/383 (40.21%), Postives = 239/383 (62.40%), Query Frame = 1
Query: 61 LQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSSR 1206
L M W+HG I+ A L P E+GLFL+RESV +PGD+ LCV + V HYR+IY + + TID ++YF +L +++EFY + + + T LTKP K G + GW+ L L +G+G+F V++ Y G+ +A K + D+T ++E +VMT ++H+NLV+ G++++ ++++TE M+ G+LVN+LRTRG+S +T I +S++V GM YLE K LVHRDLA RNIL+ + AKI+DFGL + ++PIKWTAPEA+ +FS SD+WS+GV+LWEI+S+G+ PY +S++ V +++E G+R+ P++CP +YSLM W P RP F + + L + ++ L ++
Sbjct: 73 LSLMPWFHGKISGSEAVCQLQPAEDGLFLVRESVRHPGDYVLCVSFSGEVIHYRVIY-QDNKLTIDNKQYFYNLIDMIEFYSKNKDSIATTLTKPKQKQGTK---SAELELSKMGWLLDMTKLRLGGIIGEGEFGAVYEGEYVGQRVAVKTI--KCDVTAQAFLQETAVMTKLQHKNLVRLLGVILNKG-LHIVTELMIKGNLVNFLRTRGRSVVTSIQLFRYSLDVCEGMEYLESKKLVHRDLAARNILVSDDNAAKISDFGLTKVVSKEADKAKLPIKWTAPEALTKEKFSTKSDVWSYGVLLWEIFSYGRQPYPKMSLKDVQAKVEAGYRMEAPEDCPANVYSLMKLCWEQEPRRRPGFPKLREKLEREMGKRSPGLPAK 448
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000059351.1 (SMESG000059351.1) HSP 1 Score: 822.772 bits (2124), Expect = 0.000e+0 Identity = 392/393 (99.75%), Postives = 392/393 (99.75%), Query Frame = 1
Query: 31 MLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSSRC 1209
MLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHY GKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSSRC
Sbjct: 1 MLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYNGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKNSILSSRC 393
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000016115.1 (SMESG000016115.1) HSP 1 Score: 296.59 bits (758), Expect = 3.258e-95 Identity = 163/420 (38.81%), Postives = 235/420 (55.95%), Query Frame = 1
Query: 76 WYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTK--PLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCV---IQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCRETDSYELG----------------------------------------------GRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNS 1182
WYHG ++R AE+ L P E G FLIR S +PGD+T+CV + D VQ Y +IY K YT+DE+ +F+S+ EL+E Y DA+GL LTK PKS L Y + + + L +G G+F+EV + Y+ ++A KC+ I ++ T E S+M + H +LV F G+ ++ +Y++TEYM NGSLVNYLR+RG++ I +Q+ F+I+ GM YLE+ LVHRDLA RNILL+ +VAK++DFGL R DS GR+P+KWTAPEA+ +N+++ SD+WSFG++LWEI+SFG+ PY I +V + G+R+ P++ P +IY LM W + P RP F + HK+L + S
Sbjct: 72 WYHGKVSRSLAEERLMPCENGTFLIRSSDKFPGDYTICVKFND-VQFYHVIYSNKG-YTLDEDSWFASMPELIEHYQKDADGLCCTLTKCYESPKSRL-------DYLDENVLNIKFEEIKLGPKIGCGEFSEVLQGEYQDTVVAVKCLKKPINFAEKTLFTF-EFSLMAKLNHPHLVTFKGISSSNESVYIITEYMENGSLVNYLRSRGRTVIKTNDQIKFAIDSCSGMCYLEEHCLVHRDLAARNILLNAKLVAKVSDFGLARVDDSRTNSENCNNNLNSNSKNHSSKTPSPKLMLNVVNDLVSLPTSSVDDNTTSVGRIPVKWTAPEALTHNKYTNKSDVWSFGILLWEIFSFGRTPYPRIYANNVKQHLLNGYRMESPEDTPNDIYELMRDCWALEPEKRPTFCEIHKILHKKMKS 481
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000042606.1 (SMESG000042606.1) HSP 1 Score: 258.84 bits (660), Expect = 1.284e-76 Identity = 140/396 (35.35%), Postives = 217/396 (54.80%), Query Frame = 1
Query: 22 SKYMLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYKGKILAAKCVIQSSDLTFVG--IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR---ETDSY--ELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKN 1188
S ++ + + +LQ WYHG I R AE LL+ G FL+RES + ++ + Y+ + H+RI D +Y + E + F ++ +L++++ A+GL L P PK V W R + ++ LG G + V++A +K + +D+T ++EA +M +++H NLV+ G+ Y++ E+M NG+L+ YLRTR K + P L +I +A GM YLEQ + +HRDLA RN L+ ++ + K+ADFGL R D+Y +G + PIKWTAPE + NQFS SD+W+FGV+LWE+ ++G PY GI +Q V +E+G + P CP IY +M W P RP+FK H L +L++ N
Sbjct: 120 SDFIEESQDCDSYLQQFKWYHGAIPRSFAEYLLNSGITGSFLVRESESNRRLRSISLRYEGKIWHFRISKDYNNKYYVTENQRFDTISKLIDYHSKFADGLPCQLLFPAPKRAQATVFGVGENDSADIWEIDRTEIMMKNQLGSGQYGIVYEAFWKKYSITVAVKTVKTDITVADDFLEEARLMKSLQHPNLVRLLGVCTQEPPNYIIAEFMENGNLLEYLRTRSKEDLPPPVLLYMAIQIAAGMEYLEQHNFIHRDLAARNCLVGQDNIVKVADFGLARCMERDDTYTAHVGAKFPIKWTAPEGLAYNQFSTKSDVWAFGVLLWELATYGMTPYPGIELQDVYVYLEKGNIMNRPAGCPDNIYDIMKQCWQWFPESRPSFKDLHNELEKMLSNIN 515
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000056885.1 (SMESG000056885.1) HSP 1 Score: 255.758 bits (652), Expect = 6.407e-76 Identity = 147/415 (35.42%), Postives = 226/415 (54.46%), Query Frame = 1
Query: 37 NTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYD-KKQRYTIDEEEYFSSLEELVEFYISDANGLVTCLTKPLPK----------------------SGLPIYPPVIHYFQQAGWVFPRDGLDLEECLGKGDFAEVFKAHYK--GKILAAKCVIQSSDLTFVG-IKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSINVACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR---ETDSY--ELGGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFKQAHKVLTTILNSKN 1188
N ++ L + WYHG ITR+ E LL G +L+R S + PG ++ + Y V HYRI +D K+ Y I E F ++ L++ + + +GL+ L P+PK S LP++ V W R + + + LG G + +V++A +K ++A K + + +L +KEA VM +RH+NLVQ G+ I YL+TEY+ G+L+++LR + +TP L + +A GM+YLE+ + +HRDLA RN L+ N + K+ DFGL R DSY ++G + PIKWTAPE + N+FS SD+W+FGVVLWE+ ++G PY GI + V +E+G+R+ P+ CP +Y +M W +P RP+F Q + L I S+N
Sbjct: 102 NKPANDSQLMAYQWYHGNITRQEGEHLLRSGINGSYLVRASESQPGQLSVTLRYDGRVYHYRIGFDIDKKLYYITENHKFPTVAFLIQHHSTFPDGLICALLYPVPKKVRTTNNEKVISKKSDFNISSSSQLPMFEDV------ENWEIDRSEILMHQKLGGGQYGDVYEAVWKRYNVVIAVKTLKEDLNLKIEDFLKEALVMKNLRHKNLVQLLGVCIKEPPFYLITEYISKGNLLHFLRKCNQLEVTPSILLYMATQIADGMTYLEENNFIHRDLAARNCLVGDNYLLKVGDFGLARYIQRDDSYTAKIGAKFPIKWTAPEGLAFNKFSSKSDIWAFGVVLWELATYGLSPYPGIELHDVYHILEKGYRMDRPEGCPEIVYGIMLQCWQWDPLLRPSFAQLYSKLYYICFSQN 510
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000016930.1 (SMESG000016930.1) HSP 1 Score: 245.358 bits (625), Expect = 6.353e-74 Identity = 145/387 (37.47%), Postives = 224/387 (57.88%), Query Frame = 1
Query: 49 SEVHLQSMVWYHGPITRETAEQLLHPRE--EGLFLIRESVNYPGDFTLCVCYQDGVQHYRIIYDKKQRYTIDEEE--------YFSSLEELVEFYISDANGLVTCLTKPLPKSGLPIYPPVIHYFQQAG---WVFPRDGLDLEECLGKGDFAEVFKAHY-KGKILAAKCVIQSSDLTFVGIKEASVMTTVRHQNLVQFHGLVIDSDKIYLLTEYMLNGSLVNYLRTRGKSGITPINQLMFSIN-VACGMSYLEQKDLVHRDLACRNILLDKNMVAKIADFGLCR----ETDSYEL--GGRVPIKWTAPEAVKNNQFSPMSDMWSFGVVLWEIYSFGKLPYSGISVQHVMSEIEQGFRLPCPQNCPPEIYSLMDAAWVINPAHRPNFK 1146
S+ +++ W+ I+R+ +E+LL + +G FLIR S P +L V Y V HYR+ +K+R+ EE F +L ELV+FY ++ANGL LT+ P+ PPVI + W R+ ++L + LG G+F EV++ + K +A K + + +KEA +M + H NLV+ + + D + IY++TE M GSL+ YLR GK T + +LM ++ +A GM+YLE++ +HRDLA RNIL+ +N + KIADFGL R +D+Y G + PIKWTAPEA +F+ SD+WS+G+VL+EI + G+ P+ ++ + ++E+G+R+P P NCP E+Y +M W P +RP FK
Sbjct: 229 SKGSVEAEDWFFYNISRKDSERLLLLKGNIQGTFLIRGSETMPDQLSLSVNYNGTVNHYRV---RKRRFPESMEEGFCITSRKMFFALPELVDFYSTEANGLCCKLTRACPRP-----PPVISDLSRNTRDRWEINRNSIELLKKLGSGNFGEVYQGIWNKTTDVAVKTLKPGTMAKEEFLKEARIMKRLNHSNLVRLYAVCSD-EPIYIVTELMTKGSLLEYLREEGKH--TELKELMDMMSQIANGMAYLEKEGYIHRDLAARNILIGENNICKIADFGLTRVIQGSSDTYNARQGAKFPIKWTAPEAALMGKFTVKSDVWSYGIVLYEIITHGQTPFPAMNNTQTLQQVEKGYRMPKPSNCPQELYKVMLYCWEALPENRPTFK 604 The following BLAST results are available for this feature:
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tyrosine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033752 ID=SMED30033752|Name=Tyrosine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1445bpback to top protein sequence of SMED30033752-orf-1 >SMED30033752-orf-1 ID=SMED30033752-orf-1|Name=SMED30033752-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=394bp MLNTNKSEVHLQSMVWYHGPITRETAEQLLHPREEGLFLIRESVNYPGDFback to top Annotated Terms
The following terms have been associated with this transcript:
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