LETM1 and EF-hand domain-containing protein 1, mitochondrial

Overview


Name	LETM1 and EF-hand domain-containing protein 1, mitochondrial
Smed ID	SMED30033722
Length (bp)	2713

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of LETM1 and EF-hand domain-containing protein 1, mitochondrial (SMED30033722) t-SNE clustered cells

Violin plots show distribution of expression levels for LETM1 and EF-hand domain-containing protein 1, mitochondrial (SMED30033722) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of LETM1 and EF-hand domain-containing protein 1, mitochondrial (SMED30033722) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033722

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30033722	SMESG000064220.1	dd_Smed_v4_4348_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30033722	SMESG000064220.1	dd_Smed_v4_4348_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
ovary	SMED30033722	SMESG000064220.1	SMED30033722	smed_20140614	PMID:279364
testis	SMED30033722	SMESG000064220.1	SMED30033722	smed_20140614	PMID:279364

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
Match: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:6556])

HSP 1 Score: 299.286 bits (765), Expect = 1.879e-88
Identity = 230/601 (38.27%), Postives = 353/601 (58.74%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGT--EERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE---DKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIES-AIANLEEAKTLF---------HKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            RV DEL HYYHGF+L + D  +A  +L R+  GH+LTRRER+Q +R  AD+ R+VPFLVF++VPFMEFLLP  +K FP MLPSTF+T+S  +E + ++L+ KLE+AKFLQ+ I E A K K  KG       FS F ++ RE+G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL M++R +K DD++IA EG+D + V ELQ   R RGMR+ GV E+RLR QL QWL L L +++PT+LL+LSR MYLP+TL+P +QLK  +  LP+ V+  A++K      E+VD K KLE   +E+  I +E                E+ K SE   D  P   + + + P T P  E+   V +S+ +      K+  P+    ++    ++   I S A + L+E K             KE++    E  +EI K LS + E   V+  E K+ K L+ ++ +MI +I+  +  +E++ +    +  +  P  E V++V  +             IN    ++ +K + ++    K  ++ + LDE+KDGK+ +D LVK+I+L++  +V + +S++A+++  +
Sbjct:  156 RVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSAT--KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREK------------ELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETL------KDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE--ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAEL-------------INA---MKQVKHIPES----KLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATL 714

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
Match: LETM2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:14648])

HSP 1 Score: 201.06 bits (510), Expect = 9.627e-56
Identity = 139/270 (51.48%), Postives = 187/270 (69.26%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIK-GDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            ++ DEL +YY+GF L + D  VA  ++ RL  G  LTRRER++L+RT  D  R+VPF+VF+IVPFMEFLLP +LK FP MLPSTF++ESK +E   +K+  KLE+AKFLQE + E A +   K GD    T  S ++KQ  ++G    T++I+RFS LFED++ LE L+   L ALCKLL++ T G   LLRFQL MK++ +K DD++IA EG+  + V ELQ   R RGMRS G+ E +LR QL++W  L L++ VP +LLLLSR  YL
Sbjct:   78 KIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDAS--TQLSSYVKQV-QTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYL 344

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
Match: LETM2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:14648])

HSP 1 Score: 201.06 bits (510), Expect = 2.668e-55
Identity = 139/270 (51.48%), Postives = 187/270 (69.26%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIK-GDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            ++ DEL +YY+GF L + D  VA  ++ RL  G  LTRRER++L+RT  D  R+VPF+VF+IVPFMEFLLP +LK FP MLPSTF++ESK +E   +K+  KLE+AKFLQE + E A +   K GD    T  S ++KQ  ++G    T++I+RFS LFED++ LE L+   L ALCKLL++ T G   LLRFQL MK++ +K DD++IA EG+  + V ELQ   R RGMRS G+ E +LR QL++W  L L++ VP +LLLLSR  YL
Sbjct:  125 KIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDAS--TQLSSYVKQV-QTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYL 391

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
Match: LETM2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:14648])

HSP 1 Score: 162.155 bits (409), Expect = 1.148e-42
Identity = 106/270 (39.26%), Postives = 145/270 (53.70%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIK-GDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            ++ DEL +YY+GF L + D  VA  ++ RL  G  LTRRER++  +    MA                                                 KLE+AKFLQE + E A +   K GD    T  S ++KQ  ++G    T++I+RFS LFED++ LE L+   L ALCKLL++ T G   LLRFQL MK++ +K DD++IA EG+  + V ELQ   R RGMRS G+ E +LR QL++W  L L++ VP +LLLLSR  YL
Sbjct:   78 KIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAV------------------------------------------------KLELAKFLQETMTEMARRNRAKMGDAS--TQLSSYVKQV-QTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYL 296

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
Match: LETM2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:14648])

HSP 1 Score: 161.384 bits (407), Expect = 5.127e-42
Identity = 106/270 (39.26%), Postives = 145/270 (53.70%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIK-GDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            ++ DEL +YY+GF L + D  VA  ++ RL  G  LTRRER++  +    MA                                                 KLE+AKFLQE + E A +   K GD    T  S ++KQ  ++G    T++I+RFS LFED++ LE L+   L ALCKLL++ T G   LLRFQL MK++ +K DD++IA EG+  + V ELQ   R RGMRS G+ E +LR QL++W  L L++ VP +LLLLSR  YL
Sbjct:  125 KIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAV------------------------------------------------KLELAKFLQETMTEMARRNRAKMGDAS--TQLSSYVKQV-QTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYL 343

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Celegans
Match: letm-1 (LETM1 (Leucine zipper, EF-hand, TransMembrane mitochondrial protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q9XVL7])

HSP 1 Score: 267.314 bits (682), Expect = 4.793e-77
Identity = 228/625 (36.48%), Postives = 356/625 (56.96%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAE-SATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANE-GIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIEL-KSVESPDTAPISEIL-----TVVKESDKVEIQKQDKEPKPIPVVTEQ------VIGAQDLAQIESAIAN--LEEAK--TLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSL-----EKTGDHEKWVTILSLL---DEDKDGKIEMDHLVKMIKLL-NSIEVKLPSSEIAKLLEVIDKEAIIA 2321
            PL  R+  EL HYYHGF+L   +  V+   L  + +G TL+RRER+QLVRT +D+ R+VPF  FIIVPFME  LP ++K FP MLPSTF+  SK++E   +++K ++E+AKFLQ+ I E    +KT   +      F+ F+K+ R  G  V  +++L+FS LFEDE+TL++L+   L++LC+L+ IN++G P +LRFQL MK+R+LK DD+ IA E G+D +   +LQ   R RGMR+ GV+E RL+ QL QWL LSL  KVP  LLLLSR +YLPE ++  ++LK  +  LP  ++ T K K    E  ++D K ++E+I+  +  I  E++  +  K+A         KE  +KA + E  K V+    A + E+       V   S   E     KEP   P   ++       +  +DL+ IE  I    ++EAK   L  +E++   KE   EI+ +     ET        K  K L  KL+ MI++++  V+ +           ED+K  I E++   ++++S    +KKER + + DV++S+  L     E+  D E+   I +LL   DED DG ++   ++++I+LL    +V + ++++A ++  + KE  +A
Sbjct:   90 PLKDRIIHELKHYYHGFRLLALETRVSAKYLWTVLRGATLSRRERQQLVRTVSDLFRLVPFSFFIIVPFMELALPIFIKLFPGMLPSTFQESSKEEEKWRKQVKLRVEMAKFLQDTIEEIGLERKTRNKESTRSLEFALFIKKVRNEGGYVSNEELLKFSKLFEDEITLDNLSMGQLRSLCRLMSINSLGSPEILRFQLNMKIRELKADDKQIAAEGGVDALSSIDLQSACRARGMRAIGVSEERLKEQLVQWLELSLNDKVPPALLLLSRTLYLPEEVSFPDRLKAIVQNLPDGLAETTKQKLTEMEGGQIDHKARIELIRSIESAIANEKKDEEKKKKAAEEALKS--KEEAEKAKVQEKEKLVDVAAQAIVHELKKDIYDAVASTSSTTEA----KEPAAKPSEAKEEKKEDITVDKKDLSHIEEIIVGGPIKEAKHDILGLREKVLEHKEDLMEINSLDGAFAET--------KIAKRLRHKLNSMIEDVDSMVDKL-----------EDEKRNIREMLIDPTVENSVD--LKKEREVRIQDVIDSLAKLKESKGEQADDGEQRERIEALLKTIDEDSDGIVDKQLVLEVIELLEKHTDVHVSAAQMASMIGTLKKEDEVA 687

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Celegans
Match: letm-1 (LETM1 (Leucine zipper, EF-hand, TransMembrane mitochondrial protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q9XVL7])

HSP 1 Score: 267.314 bits (682), Expect = 6.360e-77
Identity = 228/625 (36.48%), Postives = 356/625 (56.96%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAE-SATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANE-GIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIEL-KSVESPDTAPISEIL-----TVVKESDKVEIQKQDKEPKPIPVVTEQ------VIGAQDLAQIESAIAN--LEEAK--TLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSL-----EKTGDHEKWVTILSLL---DEDKDGKIEMDHLVKMIKLL-NSIEVKLPSSEIAKLLEVIDKEAIIA 2321
            PL  R+  EL HYYHGF+L   +  V+   L  + +G TL+RRER+QLVRT +D+ R+VPF  FIIVPFME  LP ++K FP MLPSTF+  SK++E   +++K ++E+AKFLQ+ I E    +KT   +      F+ F+K+ R  G  V  +++L+FS LFEDE+TL++L+   L++LC+L+ IN++G P +LRFQL MK+R+LK DD+ IA E G+D +   +LQ   R RGMR+ GV+E RL+ QL QWL LSL  KVP  LLLLSR +YLPE ++  ++LK  +  LP  ++ T K K    E  ++D K ++E+I+  +  I  E++  +  K+A         KE  +KA + E  K V+    A + E+       V   S   E     KEP   P   ++       +  +DL+ IE  I    ++EAK   L  +E++   KE   EI+ +     ET        K  K L  KL+ MI++++  V+ +           ED+K  I E++   ++++S    +KKER + + DV++S+  L     E+  D E+   I +LL   DED DG ++   ++++I+LL    +V + ++++A ++  + KE  +A
Sbjct:   90 PLKDRIIHELKHYYHGFRLLALETRVSAKYLWTVLRGATLSRRERQQLVRTVSDLFRLVPFSFFIIVPFMELALPIFIKLFPGMLPSTFQESSKEEEKWRKQVKLRVEMAKFLQDTIEEIGLERKTRNKESTRSLEFALFIKKVRNEGGYVSNEELLKFSKLFEDEITLDNLSMGQLRSLCRLMSINSLGSPEILRFQLNMKIRELKADDKQIAAEGGVDALSSIDLQSACRARGMRAIGVSEERLKEQLVQWLELSLNDKVPPALLLLSRTLYLPEEVSFPDRLKAIVQNLPDGLAETTKQKLTEMEGGQIDHKARIELIRSIESAIANEKKDEEKKKKAAEEALKS--KEEAEKAKVQEKEKLVDVAAQAIVHELKKDIYDAVASTSSTTEA----KEPAAKPSEAKEEKKEDITVDKKDLSHIEEIIVGGPIKEAKHDILGLREKVLEHKEDLMEINSLDGAFAET--------KIAKRLRHKLNSMIEDVDSMVDKL-----------EDEKRNIREMLIDPTVENSVD--LKKEREVRIQDVIDSLAKLKESKGEQADDGEQRERIEALLKTIDEDSDGIVDKQLVLEVIELLEKHTDVHVSAAQMASMIGTLKKEDEVA 687

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Fly
Match: Letm1 (gene:FBgn0284252 transcript:FBtr0072349)

HSP 1 Score: 266.544 bits (680), Expect = 4.891e-75
Identity = 146/310 (47.10%), Postives = 208/310 (67.10%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAG-TEERVD 1460
            PL  R+ DELVHYYHGF+L F D+ +   +L R+  G TLTRRE KQL RT++D+ R++PF VFIIVPFME LLP ++KFFP MLPSTF+T +  +E + Q L  +LE+AKFLQ+ + +   +   +    +   F  F  + R     V   +I++F+  F+DE+TL+SL+ + L ALC++L++NTIG   LLRFQL +K+R L  DD++IA EG+D + + ELQQ  + RGMR+YG+ E RLR+QL +W+ LSL ++VP TLLLLSR M + +     ++LK+ I VLP  V    +   G +E +VD
Sbjct:  180 PLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHK-EHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAHTRHAIGESEGKVD 488

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Fly
Match: Letm1 (gene:FBgn0284252 transcript:FBtr0072348)

HSP 1 Score: 266.544 bits (680), Expect = 4.891e-75
Identity = 146/310 (47.10%), Postives = 208/310 (67.10%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAG-TEERVD 1460
            PL  R+ DELVHYYHGF+L F D+ +   +L R+  G TLTRRE KQL RT++D+ R++PF VFIIVPFME LLP ++KFFP MLPSTF+T +  +E + Q L  +LE+AKFLQ+ + +   +   +    +   F  F  + R     V   +I++F+  F+DE+TL+SL+ + L ALC++L++NTIG   LLRFQL +K+R L  DD++IA EG+D + + ELQQ  + RGMR+YG+ E RLR+QL +W+ LSL ++VP TLLLLSR M + +     ++LK+ I VLP  V    +   G +E +VD
Sbjct:  180 PLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHK-EHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAHTRHAIGESEGKVD 488

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Fly
Match: Letm1 (gene:FBgn0284252 transcript:FBtr0072347)

HSP 1 Score: 266.544 bits (680), Expect = 4.891e-75
Identity = 146/310 (47.10%), Postives = 208/310 (67.10%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAG-TEERVD 1460
            PL  R+ DELVHYYHGF+L F D+ +   +L R+  G TLTRRE KQL RT++D+ R++PF VFIIVPFME LLP ++KFFP MLPSTF+T +  +E + Q L  +LE+AKFLQ+ + +   +   +    +   F  F  + R     V   +I++F+  F+DE+TL+SL+ + L ALC++L++NTIG   LLRFQL +K+R L  DD++IA EG+D + + ELQQ  + RGMR+YG+ E RLR+QL +W+ LSL ++VP TLLLLSR M + +     ++LK+ I VLP  V    +   G +E +VD
Sbjct:  180 PLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHK-EHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAHTRHAIGESEGKVD 488

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
Match: letm1 (leucine zipper-EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:570745])

HSP 1 Score: 328.946 bits (842), Expect = 1.322e-99
Identity = 231/598 (38.63%), Postives = 360/598 (60.20%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE----DKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            RV DE+ HYYHGF+L + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R ++ DD++IA EG+D +   ELQ   R RGMR+ GV E RLR QL QWL L L + +PT+LLLLSR M+LP+TL+P +QLK  +  LP+ ++  A++K    +  +VD KTKLE   +E+  I +E    +  +     LAD   K  E     +A ++E++     D       + V   S+ +    +D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI + LS + +   V+  E K+ + LS +++ MI  ++K +  +E +           K V++  M     DS  +P I  E  I++N+++  +K ++   +H K ++I   LDE+KDGKI++D ++K+++L++  ++ + ++++A+++
Sbjct:  163 RVIDEVKHYYHGFRLLWIDTTIAVRMLWRVLNGHILSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKASKGNVTE--EFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELER-----LADAAEKAKEQTQSQEAEVLEVEGERRVDAEHALSSVDVAIHSETL----RDTAPVLEGIKGEE-ITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVE--ESKASQRLSKRVNRMIGRMDKIITELEKD-----------KMVLDGQM-----DSETTPPI-GENLISINELITVMKQIQNIPEH-KLLSIADALDENKDGKIDIDDVIKVVELIDKEDIDISTNQVAEIM 728

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
Match: letm1 (leucine zipper-EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:570745])

HSP 1 Score: 327.791 bits (839), Expect = 3.267e-99
Identity = 231/603 (38.31%), Postives = 361/603 (59.87%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE----DKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIK-----KERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            RV DE+ HYYHGF+L + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R ++ DD++IA EG+D +   ELQ   R RGMR+ GV E RLR QL QWL L L + +PT+LLLLSR M+LP+TL+P +QLK  +  LP+ ++  A++K    +  +VD KTKLE   +E+  I +E    +  +     LAD   K  E     +A ++E++     D       + V   S+ +    +D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI + LS + +   V+  E K+ + LS +++ MI  ++K +  +E +           K V++  M     DS  +P I      +E  I++N+++  +K ++   +H K ++I   LDE+KDGKI++D ++K+++L++  ++ + ++++A+++
Sbjct:  147 RVIDEVKHYYHGFRLLWIDTTIAVRMLWRVLNGHILSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKASKGNVTE--EFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELER-----LADAAEKAKEQTQSQEAEVLEVEGERRVDAEHALSSVDVAIHSETL----RDTAPVLEGIKGEE-ITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVE--ESKASQRLSKRVNRMIGRMDKIITELEKD-----------KMVLDGQM-----DSETTPPIGVFLSYRENLISINELITVMKQIQNIPEH-KLLSIADALDENKDGKIDIDDVIKVVELIDKEDIDISTNQVAEIM 718

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
Match: letm1 (leucine zipper-EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:570745])

HSP 1 Score: 325.865 bits (834), Expect = 2.855e-98
Identity = 231/608 (37.99%), Postives = 361/608 (59.38%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE----DKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIK----------KERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            RV DE+ HYYHGF+L + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R ++ DD++IA EG+D +   ELQ   R RGMR+ GV E RLR QL QWL L L + +PT+LLLLSR M+LP+TL+P +QLK  +  LP+ ++  A++K    +  +VD KTKLE   +E+  I +E    +  +     LAD   K  E     +A ++E++     D       + V   S+ +    +D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI + LS + +   V+  E K+ + LS +++ MI  ++K +  +E +           K V++  M     DS  +P I           +E  I++N+++  +K ++   +H K ++I   LDE+KDGKI++D ++K+++L++  ++ + ++++A+++
Sbjct:  163 RVIDEVKHYYHGFRLLWIDTTIAVRMLWRVLNGHILSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKASKGNVTE--EFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELER-----LADAAEKAKEQTQSQEAEVLEVEGERRVDAEHALSSVDVAIHSETL----RDTAPVLEGIKGEE-ITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVE--ESKASQRLSKRVNRMIGRMDKIITELEKD-----------KMVLDGQM-----DSETTPPIGLFFEKRSDLPRENLISINELITVMKQIQNIPEH-KLLSIADALDENKDGKIDIDDVIKVVELIDKEDIDISTNQVAEIM 739

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
Match: letm2 (leucine zipper-EF-hand containing transmembrane protein 2 [Source:ZFIN;Acc:ZDB-GENE-090521-4])

HSP 1 Score: 204.527 bits (519), Expect = 6.854e-57
Identity = 162/322 (50.31%), Postives = 217/322 (67.39%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEERVDP-KTKLEVIKEEQKVI 1505
            +V DEL HYYHGF+L   D  +A  ++ RL  G  LTRRER++L+RT AD+ R+VPF++F+IVPFMEFLLP +LK FP MLPSTF+TE+K +E   + L  KLE+AKFLQE IAE A + K   GD  +   FS +++Q R +G    T+DI++FS LFEDE+TLE L    L ALCKLL++  IG   LLRFQL M++R +K DD+MIA EG+  + V ELQ   R RGMRS G+  ++LR QL QWL L L++ VP +LLLLSR MYL + LTP+  +   +  L KT  N   ++A T  + +P  + +EV+ +   VI
Sbjct:  122 KVLDELKHYYHGFRLLGIDTKIAGRMVWRLLHGQQLTRRERRRLMRTCADLFRLVPFMLFVIVPFMEFLLPVFLKLFPEMLPSTFETETKKEEKQKKGLAAKLELAKFLQETIAEMARRNKAAVGD--ETQKFSTYVQQVRHTGEQPSTKDIVKFSKLFEDELTLEHLERPQLVALCKLLELQPIGTNNLLRFQLMMQLRTIKADDEMIATEGVSVMTVAELQAACRSRGMRSLGLTTDQLRQQLQQWLDLHLKENVPPSLLLLSRAMYLTD-LTPKPPVIPPVPKLEKT--NAPPVEADTSAKGNPLSSSVEVMVDSAPVI 438

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
Match: letm2 (leucine zipper-EF-hand containing transmembrane protein 2 [Source:ZFIN;Acc:ZDB-GENE-090521-4])

HSP 1 Score: 160.999 bits (406), Expect = 3.695e-42
Identity = 129/325 (39.69%), Postives = 175/325 (53.85%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEERVDP-KTKLEVIKEEQKVI 1505
            L  +V DEL HYYHGF+L   D  +A  ++ RL  G  LTRRER++  +    +A                                                 KLE+AKFLQE IAE A + K   GD  +   FS +++Q R +G    T+DI++FS LFEDE+TLE L    L ALCKLL++  IG   LLRFQL M++R +K DD+MIA EG+  + V ELQ   R RGMRS G+  ++LR QL QWL L L++ VP +LLLLSR MYL + LTP+  +   +  L KT  N   ++A T  + +P  + +EV+ +   VI
Sbjct:  119 LGQKVLDELKHYYHGFRLLGIDTKIAGRMVWRLLHGQQLTRRERRREEKQKKGLA------------------------------------------------AKLELAKFLQETIAEMARRNKAAVGD--ETQKFSTYVQQVRHTGEQPSTKDIVKFSKLFEDELTLEHLERPQLVALCKLLELQPIGTNNLLRFQLMMQLRTIKADDEMIATEGVSVMTVAELQAACRSRGMRSLGLTTDQLRQQLQQWLDLHLKENVPPSLLLLSRAMYLTD-LTPKPPVIPPVPKLEKT--NAPPVEADTSAKGNPLSSSVEVMVDSAPVI 390

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
Match: anapc1 (anaphase promoting complex subunit 1 [Source:Xenbase;Acc:XB-GENE-5894738])

HSP 1 Score: 318.931 bits (816), Expect = 1.646e-95
Identity = 235/609 (38.59%), Postives = 378/609 (62.07%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLK-AGTE-ERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKE------------SDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DE+ HYYHGF+L + D  +A  +L+++  GH ++RRER+Q +R  AD+ R+VPFLVF+IVPFMEFLLP  LK FP MLPSTF+T SK +E + ++L+ KLE+AKFLQ+ I E A + K  KGD      F+ F ++ R +G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R +K DD++IA+EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L++++PT+LLLLSR +YLP+TL+P +QLK  +  LP++V+  A++K A  E E+VD KTKLE   +E++ I +E +  +  +     LAD   KES+  A  ++++S  +P+ A   E+ T   +            S++ EI K D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI K LS + +   ++  E K+ K L+ +++ MI +++K +  +E E K           V++E +   S+         +E  +++N+++  ++ ++K  + +K   I + LDE+KDGKI++D + K+++L++  ++ + +S++A+++E++
Sbjct:  158 KVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVT--AEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMER-----LAD-AAKESQQVAAKVDVQS--APEEAISGEMKTATADTAAEPAVAQMSASEQAEILK-DTAPVLEGIKGEE-ITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQ--ETKASKILTKRVNRMIGQMDKIISELENEEK-----------VLDEHIEKGSVPPVGLYFAFRENLVSINELISIMRHIQKIPE-QKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELL 740

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
Match: anapc1 (anaphase promoting complex subunit 1 [Source:Xenbase;Acc:XB-GENE-5894738])

HSP 1 Score: 315.849 bits (808), Expect = 4.339e-95
Identity = 229/599 (38.23%), Postives = 370/599 (61.77%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLK-AGTE-ERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIE--LKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DE+ HYYHGF+L + D  +A  +L+++  GH ++RRER+Q +R  AD+ R+VPFLVF+IVPFMEFLLP  LK FP MLPSTF+T SK +E + ++L+ KLE+AKFLQ+ I E A + K  KGD      F+ F ++ R +G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R +K DD++IA+EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L++++PT+LLLLSR +YLP+TL+P +QLK  +  LP++V+  A++K A  E E+VD KTKLE   +E++ I +E +  +  +     LAD   +  +  A ++   L  VE   T   S+   ++K++  V           +  +  + I  +++  +  A   L+E K L    KEE+  LK       E  +EI K LS + +   ++  E K+ K L+ +++ MI +++K +  +E E K           V++E +   S+     PV   E  +++N+++  ++ ++K  + +K   I + LDE+KDGKI++D + K+++L++  ++ + +S++A+++E++
Sbjct:  117 KVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVT--AEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMER-----LADAAKESQQVAAKVMASLLNGVELCGTGATSQDSEILKDTAPV-----------LEGIKGEEITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQ--ETKASKILTKRVNRMIGQMDKIISELENEEK-----------VLDEHIEKGSV----PPV--GENLVSINELISIMRHIQKIPE-QKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELL 677

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
Match: anapc1 (anaphase promoting complex subunit 1 [Source:Xenbase;Acc:XB-GENE-5894738])

HSP 1 Score: 315.849 bits (808), Expect = 6.087e-95
Identity = 233/597 (39.03%), Postives = 367/597 (61.47%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLK-AGTE-ERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DE+ HYYHGF+L + D  +A  +L+++  GH ++RRER+Q +R  AD+ R+VPFLVF+IVPFMEFLLP  LK FP MLPSTF+T SK +E + ++L+ KLE+AKFLQ+ I E A + K  KGD      F+ F ++ R +G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R +K DD++IA+EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L++++PT+LLLLSR +YLP+TL+P +QLK  +  LP++V+  A++K A  E E+VD KTKLE   +E++ I +E +  +  +     LAD   KES+  A             A +   +  +  S++ EI K D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI K LS + +   ++  E K+ K L+ +++ MI +++K +  +E E K  D   E                SS  P+   E  +++N+++  ++ ++K  + +K   I + LDE+KDGKI++D + K+++L++  ++ + +S++A+++E++
Sbjct:  130 KVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVT--AEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMER-----LAD-AAKESQQVA-------------AKVMATVAQMSASEQAEILK-DTAPVLEGIKGEE-ITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQ--ETKASKILTKRVNRMIGQMDKIISELENEEKVLDEHIEK--------------GSSDCPL---ENLVSINELISIMRHIQKIPE-QKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELL 683

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
Match: anapc1 (anaphase promoting complex subunit 1 [Source:Xenbase;Acc:XB-GENE-5894738])

HSP 1 Score: 311.612 bits (797), Expect = 1.951e-93
Identity = 231/600 (38.50%), Postives = 369/600 (61.50%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLK-AGTE-ERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIE--LKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPI-PVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DE+ HYYHGF+L + D  +A  +L+++  GH ++RRER+Q +R  AD+ R+VPFLVF+IVPFMEFLLP  LK FP MLPSTF+T SK +E + ++L+ KLE+AKFLQ+ I E A + K  KGD      F+ F ++ R +G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R +K DD++IA+EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L++++PT+LLLLSR +YLP+TL+P +QLK  +  LP++V+  A++K A  E E+VD KTKLE   +E++ I +E +  +  +     LAD   +  +  A ++   L  VE      +SEIL               K+  P+   +  + I  +++  +  A   L+E K L    KEE+  LK       E  +EI K LS + +   ++  E K+ K L+ +++ MI +++K +  +E E K           V++E +   S+     PV   E  +++N+++  ++ ++K  + +K   I + LDE+KDGKI++D + K+++L++  ++ + +S++A+++E++
Sbjct:  133 KVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVT--AEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMER-----LADAAKESQQVAAKVMASLLNGVE------LSEIL---------------KDTAPVLEGIKGEEITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQ--ETKASKILTKRVNRMIGQMDKIISELENEEK-----------VLDEHIEKGSV----PPV--GENLVSINELISIMRHIQKIPE-QKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELL 684

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
Match: anapc1 (anaphase promoting complex subunit 1 [Source:Xenbase;Acc:XB-GENE-5894738])

HSP 1 Score: 309.686 bits (792), Expect = 1.055e-92
Identity = 229/599 (38.23%), Postives = 367/599 (61.27%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLK-AGTE-ERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIE--LKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DE+ HYYHGF+L + D  +A  +L+++  GH ++RRER+Q +R  AD+ R+VPFLVF+IVPFMEFLLP  LK FP MLPSTF+T SK +E + ++L+ KLE+AKFLQ+ I E A + K  KGD      F+ F ++ R +G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R +K DD++IA+EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L++++PT+LLLLSR +YLP+TL+P +QLK  +  LP++V+  A++K A  E E+VD KTKLE   +E++ I +E +  +  +     LAD   +  +  A ++   L  VE          L+ +  S++ EI K D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI K LS + +   ++  E K+ K L+ +++ MI +++K +  +E E               E+V+              +E  +++N+++  ++ ++K  + +K   I + LDE+KDGKI++D + K+++L++  ++ + +S++A+++E++
Sbjct:  129 KVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVT--AEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMER-----LADAAKESQQVAAKVMASLLNGVE----------LSQMSASEQAEILK-DTAPVLEGIKGEE-ITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQ--ETKASKILTKRVNRMIGQMDKIISELENE---------------EKVLYFAF----------RENLVSINELISIMRHIQKIPE-QKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELL 680

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Mouse
Match: Letm1 (leucine zipper-EF-hand containing transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:1932557])

HSP 1 Score: 295.049 bits (754), Expect = 3.382e-87
Identity = 225/604 (37.25%), Postives = 351/604 (58.11%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAG--TEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAP-------ISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAK---------TLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DEL HYYHGF+L + D  +A  +L R+  GHTLTRRER+Q +R  AD+ R+VPFLVF++VPFMEFLLP  +K FP MLPSTF+T+S  +E + ++L+ KLE+AKFLQ+ I E A K K  KG+      FS F ++ RE+G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL M++R +K DD++I+ EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L  ++PT+LL+LSR MYLP+TL+P +QLK  +  LP+ V+  A++K      E+VD K KLE   +E+  I             E+  A E +K+ + +     L     P+  P        SE+LT             D  P  +  +  + I  +++  +  A + L+E K             KE++    E  +EI K LS + E   ++  E  + K LS ++ +MI +I+  +  +E        +++D K        +    S+P+     E  I++ +++ ++K ++   +H K +++ S LD++KDG I +D LVK+I L+N  +V++ ++++A+++  +
Sbjct:  155 KVLDELRHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATK--DFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQ-------QEHLEELKRASEAVKDIQPEVAEATLPGRPGPEPQPPVDDVILPSEVLT-------------DTAPV-LEGLKGEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIE--ESAASKRLSKRVQQMIGQIDGLITQLET-------TQQDGK--------LGPSQSTPT----GESVISITELISAMKQIKHIPEH-KLISLTSALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATL 713

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Mouse
Match: Letm2 (leucine zipper-EF-hand containing transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:2444979])

HSP 1 Score: 199.904 bits (507), Expect = 3.786e-55
Identity = 137/270 (50.74%), Postives = 186/270 (68.89%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIK-GDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            ++ +EL +YY GF L + D  VA  I+ RL  G+ LTRRER++L+RT AD+ R+VPF+VFIIVPFMEFL+P +LK FP MLPSTF++ESK +E   + +  KLEIAKFLQE + E A +   K GD    +  S ++KQ  ++G    T++I+RFS LF+D++ LE L+   L ALCKLL++ T G   LLRFQL M ++ +K DD++IA EG+  + V ELQ   R RGMRS G+ E +L  QL+ WL L L++ VP +LLLLSR  YL
Sbjct:  123 KIVNELKYYYKGFSLLWIDTKVAARIVWRLLHGNALTRRERRRLLRTCADVFRLVPFMVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKTMAAKLEIAKFLQETMTEMARRNRAKLGDAS--SQLSSYVKQV-QTGHKPSTKEIVRFSKLFKDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMTLKSIKADDEIIAKEGVKALSVSELQSACRARGMRSLGLTEEQLCQQLTGWLDLHLKENVPPSLLLLSRTFYL 389

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Mouse
Match: Letm2 (leucine zipper-EF-hand containing transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:2444979])

HSP 1 Score: 81.6481 bits (200), Expect = 2.105e-16
Identity = 79/157 (50.32%), Postives = 107/157 (68.15%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIK-GDGVDLTTFSDFMKQARESGLTVDTQDILRFSH 1013
            ++ +EL +YY GF L + D  VA  I+ RL  G+ LTRRER++L+RT AD+ R+VPF+VFIIVPFMEFL+P +LK FP MLPSTF++ESK +E   + +  KLEIAKFLQE + E A +   K GD    +  S ++KQ    GL V  Q +L +S+
Sbjct:  123 KIVNELKYYYKGFSLLWIDTKVAARIVWRLLHGNALTRRERRRLLRTCADVFRLVPFMVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKTMAAKLEIAKFLQETMTEMARRNRAKLGDAS--SQLSSYVKQVM--GL-VPGQRLLGWSY 274

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Mouse
Match: Letm2 (leucine zipper-EF-hand containing transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:2444979])

HSP 1 Score: 65.855 bits (159), Expect = 2.071e-11
Identity = 56/97 (57.73%), Postives = 74/97 (76.29%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQ 836
            ++ +EL +YY GF L + D  VA  I+ RL  G+ LTRRER++L+RT AD+ R+VPF+VFIIVPFMEFL+P +LK FP MLPSTF++ESK    IL+
Sbjct:  123 KIVNELKYYYKGFSLLWIDTKVAARIVWRLLHGNALTRRERRRLLRTCADVFRLVPFMVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKVHGILK 219

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
Match: sp|Q5ZK33|LETM1_CHICK (Mitochondrial proton/calcium exchanger protein OS=Gallus gallus OX=9031 GN=LETM1 PE=2 SV=1)

HSP 1 Score: 336.265 bits (861), Expect = 2.057e-101
Identity = 234/598 (39.13%), Postives = 362/598 (60.54%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAG--TEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEP-KPIPVVTEQVIG----AQDLAQIESAIANLEEAK------TLFHKEEIGVLKESRKEISKI--LSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            R+ DEL HYYHGF+L + D  +A  +L R+  G+TL+RRER+Q +R  AD+ R+VPFLVF++VPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A K K  KG+      FS F ++ RE+G     ++ILRFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL M++R +K DD+MIA EG+D + V ELQ   R RGMR+ GV E RLR QL QWL L L +++PT+LL+LSR MYLP+TL+P +QLK  +  LP++V+  A++K      E+VD K +LE   +E+  I    + ++  +   I  A E  KE+   A  ++L+S    + A +    + V    K E+ K D E  K    V E + G     +++  +  A   L+E K          +E  G ++E  +++ +I  LS + +   V+  E K+ K L+ +++ MI +I+K +  +E   K  D             + +   DS P+     E  I++ +++ ++K ++K  + EK   I   LDE+KDGKI++D++VK+++L++  +V + +S++A+++
Sbjct:  153 RIVDELKHYYHGFRLLWIDTKIAARMLWRILHGNTLSRRERRQFLRICADLFRLVPFLVFLVVPFMEFLLPVALKLFPNMLPSTFETKSKKEERLKKQLRVKLELAKFLQDTIEEMALKNKAAKGNVT--KDFSTFFQKIRETGERPSNEEILRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRTIKADDKMIAEEGVDSLTVKELQAACRARGMRALGVTEERLREQLKQWLDLHLNQEIPTSLLILSRAMYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAEVEGEKVDNKARLEATLQEEAAIR---KENEEKEMERITEAAEKAKETLQVAA-MKLESAVDLEPAVLQVKESQVAMDSKQELAKADMETLKDTAPVLEGIKGEEITKEEIDMLSDACNKLQEQKKSLTKEKEELEELKGDIQEYNEDLQEIKELSKAGQEEVVE--ESKASKRLTKRVNRMIGQIDKIINELETNQKTVD-------------VKLDRGDSPPA----GENLISIAELINAMKQIQKIPE-EKLTRIAEALDENKDGKIDIDNVVKVVELIDKEDVDIGTSQVAEIM 724

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
Match: sp|Q0VCA3|LETM1_BOVIN (Mitochondrial proton/calcium exchanger protein OS=Bos taurus OX=9913 GN=LETM1 PE=2 SV=1)

HSP 1 Score: 332.798 bits (852), Expect = 2.607e-100
Identity = 230/608 (37.83%), Postives = 360/608 (59.21%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGT--EERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLAD-------EVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKE---------EIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            PL  RV DEL HYYHGF+L + D  +A  +L R+  GH+LTRRER+Q +R  AD+ R+VPFL F++VPFMEFLLP  +K FP MLPSTF+T+S  +E + ++L+ KLE+AKFLQ+ I E A K K  KG       FS F ++ RE+G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL M++R +K DD++IA EG+D + V ELQ   R RGMR+ GV E+RLR QL QWL L L +++PT+LL+LSR MYLPETL+P +QLK  +  LP+ V+  A++K      E+VD K KLE   +E+  I +E    +  ++++  +A        EV+ E     P+ EL+  E   T P SE+L   K+S  V           +  + E+ I  +++  + +A + L+E K    KE         ++    +  +EI K LS + E   V+  E K+ K L+ ++ +MI +++  +  +E + K                     +  +       E  I+V++++ ++K ++   +  K +++ S LD++KDGK+++D LVK+I+L++  +V + +S++A+++  +
Sbjct:  138 PLGQRVLDELRHYYHGFRLLWIDTKIAARMLWRILHGHSLTRRERRQFLRICADLFRLVPFLFFVVVPFMEFLLPVAVKLFPNMLPSTFETQSSKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSAT--KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLELHLHQEIPTSLLILSRAMYLPETLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQRKSQAAVAQAAKEVEPEVVAEGAPGRPVAELQPEEPAVTLP-SEVL---KDSAPV-----------LEGLKEEEITQEEIDVLSNACSKLKEQKKSLTKEKEELELLKGDVQDYSQDLQEIKKELSKTGEEMYVE--ESKASKRLTKRVQQMIGQMDSLLAQLEADQKAG------------------RLGPAAEAAPAGETVISVSELINAMKQIKHIPES-KLLSLASALDDNKDGKVDIDDLVKVIELVDKEDVHISTSQVAEIVATL 707

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
Match: sp|Q1LY46|LETM1_DANRE (Mitochondrial proton/calcium exchanger protein OS=Danio rerio OX=7955 GN=letm1 PE=3 SV=2)

HSP 1 Score: 328.946 bits (842), Expect = 9.982e-99
Identity = 231/598 (38.63%), Postives = 360/598 (60.20%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE----DKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            RV DE+ HYYHGF+L + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R ++ DD++IA EG+D +   ELQ   R RGMR+ GV E RLR QL QWL L L + +PT+LLLLSR M+LP+TL+P +QLK  +  LP+ ++  A++K    +  +VD KTKLE   +E+  I +E    +  +     LAD   K  E     +A ++E++     D       + V   S+ +    +D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI + LS + +   V+  E K+ + LS +++ MI  ++K +  +E +           K V++  M     DS  +P I  E  I++N+++  +K ++   +H K ++I   LDE+KDGKI++D ++K+++L++  ++ + ++++A+++
Sbjct:  163 RVIDEVKHYYHGFRLLWIDTTIAVRMLWRVLNGHILSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKASKGNVTE--EFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELER-----LADAAEKAKEQTQSQEAEVLEVEGERRVDAEHALSSVDVAIHSETL----RDTAPVLEGIKGEE-ITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVE--ESKASQRLSKRVNRMIGRMDKIITELEKD-----------KMVLDGQM-----DSETTPPI-GENLISINELITVMKQIQNIPEH-KLLSIADALDENKDGKIDIDDVIKVVELIDKEDIDISTNQVAEIM 728

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BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
Match: sp|Q0VA06|LETM1_XENTR (Mitochondrial proton/calcium exchanger protein OS=Xenopus tropicalis OX=8364 GN=letm1 PE=2 SV=1)

HSP 1 Score: 318.161 bits (814), Expect = 1.399e-94
Identity = 237/609 (38.92%), Postives = 379/609 (62.23%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLK-AGTE-ERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKE------------SDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLF--HKEEIGVLK-------ESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            +V DE+ HYYHGF+L + D  +A  +L+++  GH ++RRER+Q +R  AD+ R+VPFLVF+IVPFMEFLLP  LK FP MLPSTF+T SK +E + ++L+ KLE+AKFLQ+ I E A + K  KGD      F+ F ++ R +G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL MK+R +K DD++IA+EG+D + V ELQ   R RGMR+ GV E+RL+ QL QWL L L++++PT+LLLLSR +YLP+TL+P +QLK  +  LP++V+  A++K A  E E+VD KTKLE   +E++ I +E +  +  +     LAD   KES+  A  ++++S  +P+ A   E+ T   +            S++ EI K D  P    +  E+ I  +++  +  A   L+E K L    KEE+  LK       E  +EI K LS + +   ++  E K+ K L+ +++ MI +++K +  +E E K           V++E +   S+     PV   E  +++N+++  ++ ++K  + +K   I + LDE+KDGKI++D + K+++L++  ++ + +S++A+++E++
Sbjct:  158 KVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVT--AEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMER-----LAD-AAKESQQVAAKVDVQS--APEEAISGEMKTATADTAAEPAVAQMSASEQAEILK-DTAPVLEGIKGEE-ITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQ--ETKASKILTKRVNRMIGQMDKIISELENEEK-----------VLDEHIEKGSV----PPV--GENLVSINELISIMRHIQKIPE-QKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELL 734

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
Match: sp|O95202|LETM1_HUMAN (Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1)

HSP 1 Score: 299.286 bits (765), Expect = 9.025e-88
Identity = 230/601 (38.27%), Postives = 353/601 (58.74%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGT--EERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE---DKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIES-AIANLEEAKTLF---------HKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVI 2300
            RV DEL HYYHGF+L + D  +A  +L R+  GH+LTRRER+Q +R  AD+ R+VPFLVF++VPFMEFLLP  +K FP MLPSTF+T+S  +E + ++L+ KLE+AKFLQ+ I E A K K  KG       FS F ++ RE+G     ++I+RFS LFEDE+TL++L    L ALCKLL++ +IG    LRFQL M++R +K DD++IA EG+D + V ELQ   R RGMR+ GV E+RLR QL QWL L L +++PT+LL+LSR MYLP+TL+P +QLK  +  LP+ V+  A++K      E+VD K KLE   +E+  I +E                E+ K SE   D  P   + + + P T P  E+   V +S+ +      K+  P+    ++    ++   I S A + L+E K             KE++    E  +EI K LS + E   V+  E K+ K L+ ++ +MI +I+  +  +E++ +    +  +  P  E V++V  +             IN    ++ +K + ++    K  ++ + LDE+KDGK+ +D LVK+I+L++  +V + +S++A+++  +
Sbjct:  156 RVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSAT--KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREK------------ELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETL------KDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE--ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAEL-------------INA---MKQVKHIPES----KLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATL 714

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
Match: A0A4S2LGI3 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009031 PE=4 SV=1)

HSP 1 Score: 397.897 bits (1021), Expect = 4.740e-121
Identity = 268/672 (39.88%), Postives = 387/672 (57.59%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTA---KLKAGTEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE-------DKAPII------ELKSVES-PDTAPI-----SEILTVVKESDK----------VEIQKQDKEP----------KPIPVVTEQV--------------IGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDET-----APVKQPEEKSVKNLSSKLDEMIDEIEKTVEHI--------------EVEAKKA-DPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKEAIIAE 2324
            LW R K E+VHYYHGF+L   ++ +A GI  RL +GH L+RRERKQLVRT AD+ R+VPF +FIIVPFMEFLLPFYLKFFPFMLPSTFK ++ + E I Q+LK KLE+ +FLQE +  +            +  F DF+K+ +ESG     ++I RFS LFED+VTLESL  K LK LC+LL + TIGP  LLRFQ+ ++VRQLK +D++IA EG+DKIPVWELQ L +ERGMR+ G+ E RLR QL+QWL+L LEK VP TLLL SR +++ +T + +  LK+AI  LP + S  A    L++     +DP+ K+E++++EQ  I   R             +    K          DKAP +      EL+S E+  D API     +E+L  V ++ K          V I   D++P           P PV   +               I A DL QIE+AI+   E+    H+E +  LKE   E +K +   +        PV +   K+   L++++ +MI+E++  +E +              EV  K A +PSE+ +  +++ + A              +R +++ND+L +++ ++K  D  KW  IL +LDED+DGKIE+ H++ +++LL +  VKL S E+ ++LE++D E + AE
Sbjct:  136 LWQRAKKEIVHYYHGFRLLGLEVRIATGICFRLLRGHALSRRERKQLVRTVADIIRLVPFAIFIIVPFMEFLLPFYLKFFPFMLPSTFKDKTSESERIRQRLKAKLEMTRFLQETLHHTTGTALEASGSPTVDEFQDFLKKVQESGQPATAEEITRFSKLFEDQVTLESLEMKQLKMLCQLLSLPTIGPSNLLRFQIWLRVRQLKAEDRLIAKEGLDKIPVWELQSLCQERGMRALGLTEERLRSQLAQWLALHLEKNVPVTLLLFSRALHVTQTSSGDLPLKEAIAQLPPSASEQAAALALESTPHAELDPRAKMELLRKEQASIKAARVQRDQELAELKSTSQAEGKTEPTTDEKLVDKAPTVKGLPKEELESGEAIVDQAPIVAAEKAEVLNTVTDTTKISHISTSEPSVTIAAPDEKPAVDAVTRISEAPAPVAASEPATAVIDKTNEEDTEISADDLNQIETAIS---ESSDALHEEALDGLKEEVAETTKRIKQHEAALVSVDRPVDKRTRKAANRLAARVGQMIEEMDTMIEKLNDERKQLLKNIELREVHVKHATEPSEQTE--MLDAIQA------------DHQRVVDINDLLLALRRIQKVPDDTKWEKILKVLDEDQDGKIELQHVLSVVELLGTENVKLSSKEVKRVLEMVDNEHLAAE 790

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
Match: A0A4S2LFQ1 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009031 PE=4 SV=1)

HSP 1 Score: 392.504 bits (1007), Expect = 5.790e-119
Identity = 268/677 (39.59%), Postives = 388/677 (57.31%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTA---KLKAGTEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESE-------DKAPII------ELKSVES-PDTAPI-----SEILTVVKESDK----------VEIQKQDKEP----------KPIPVVTEQV--------------IGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDET-----APVKQPEEKSVKNLSSKLDEMIDEIEKTVEHI--------------EVEAKKA-DPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHL-----VKMIKLLNSIEVKLPSSEIAKLLEVIDKEAIIAE 2324
            LW R K E+VHYYHGF+L   ++ +A GI  RL +GH L+RRERKQLVRT AD+ R+VPF +FIIVPFMEFLLPFYLKFFPFMLPSTFK ++ + E I Q+LK KLE+ +FLQE +  +            +  F DF+K+ +ESG     ++I RFS LFED+VTLESL  K LK LC+LL + TIGP  LLRFQ+ ++VRQLK +D++IA EG+DKIPVWELQ L +ERGMR+ G+ E RLR QL+QWL+L LEK VP TLLL SR +++ +T + +  LK+AI  LP + S  A    L++     +DP+ K+E++++EQ  I   R             +    K          DKAP +      EL+S E+  D API     +E+L  V ++ K          V I   D++P           P PV   +               I A DL QIE+AI+   E+    H+E +  LKE   E +K +   +        PV +   K+   L++++ +MI+E++  +E +              EV  K A +PSE+ +  +++ + A              +R +++ND+L +++ ++K  D  KW  IL +LDED+DGKIE+ H+     +++++LL +  VKL S E+ ++LE++D E + AE
Sbjct:  136 LWQRAKKEIVHYYHGFRLLGLEVRIATGICFRLLRGHALSRRERKQLVRTVADIIRLVPFAIFIIVPFMEFLLPFYLKFFPFMLPSTFKDKTSESERIRQRLKAKLEMTRFLQETLHHTTGTALEASGSPTVDEFQDFLKKVQESGQPATAEEITRFSKLFEDQVTLESLEMKQLKMLCQLLSLPTIGPSNLLRFQIWLRVRQLKAEDRLIAKEGLDKIPVWELQSLCQERGMRALGLTEERLRSQLAQWLALHLEKNVPVTLLLFSRALHVTQTSSGDLPLKEAIAQLPPSASEQAAALALESTPHAELDPRAKMELLRKEQASIKAARVQRDQELAELKSTSQAEGKTEPTTDEKLVDKAPTVKGLPKEELESGEAIVDQAPIVAAEKAEVLNTVTDTTKISHISTSEPSVTIAAPDEKPAVDAVTRISEAPAPVAASEPATAVIDKTNEEDTEISADDLNQIETAIS---ESSDALHEEALDGLKEEVAETTKRIKQHEAALVSVDRPVDKRTRKAANRLAARVGQMIEEMDTMIEKLNDERKQLLKNIELREVHVKHATEPSEQTE--MLDAIQA------------DHQRVVDINDLLLALRRIQKVPDDTKWEKILKVLDEDQDGKIELQHVLSLKNLQVVELLGTENVKLSSKEVKRVLEMVDNEHLAAE 795

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
Match: C1LG65 (Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 388.267 bits (996), Expect = 3.021e-118
Identity = 281/716 (39.25%), Postives = 417/716 (58.24%), Query Frame = 3

Query:  309 HLFAKKFLFGHIHFGFFENNRYL--HTTVFIRCLNDKKESIEKPLGEKMLTSNEDTKGVELXXXXXXXXXXXXXXXXPLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTA---KLKAGTEERVDPKTKLEVIKEEQKVI-----HXXXXXXXXXXXXXIVLADEVLKESEDKAPIIE-LKSVESPDTAP-ISEILTVVKESDKVEIQKQDKEPKPIPVV------------------------------TEQV--IGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVK---NLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKER--YINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKE 2309
            +  A +FLF H+     ++++ +  H    I  +N KK  IE P+ E   T++ +          +  +  K+  K  LW+R+K E+VHYYHG +L   ++G+A GI  R+  GHTLTRRERKQLVRT AD+ R+VPF VFIIVPFME LLPFYLKFFPFMLPSTFK +S +   I Q+LK KLE+  FLQE + ++        D   +  F +F+K+ ++SG     +DI RFS LFED+VTL+SL+ K L+ LC+LL + TIGP  LLRFQ+ M+VRQLK +D++IA+EG+D IP WELQ L +ERGMRS G+ + +L+ QLS+WL+L LE+ VP TLLL SR +++ + L  +  L+QAI  LP + S+ A    L+      +DP TK++V++EEQ  I       ++E  +  K  ++  A   L E +D+AP+++ LK+ E     P +++  T + E+  +++Q     P   PV                               TE++  I A DLA+I SAIA   E+      E I  LKE   E +K+   ++  A  +  +++  K    L S++D +I E++  V+++  +  +   + ED++  I+E    K   S     IK ++   +++ D+L S+K +    D+ KW  IL LLDED DGKIEM HL+ +I+LL +  VKL S EIA++LE+ D E
Sbjct:   58 YFSANRFLFAHV-----QDSKRIEKHIDFPIWIINPKK--IETPIPEVNNTTSSNPSVQPTSEEPNKNNNEKKITKPSLWVRIKKEIVHYYHGIRLLVLEVGIASGICFRVLGGHTLTRRERKQLVRTLADILRLVPFAVFIIVPFMELLLPFYLKFFPFMLPSTFKDKSAEANAIQQRLKAKLELTHFLQETLLQTTGAIKSDSDTPTVDEFQEFIKKVQKSGEQAQAKDITRFSKLFEDQVTLDSLDNKQLRMLCQLLSLPTIGPSHLLRFQIWMRVRQLKAEDKLIASEGVDHIPPWELQSLCQERGMRSVGLPKEKLQSQLSEWLNLHLEQNVPITLLLFSRALHVTQALVDQNPLQQAIAQLPPSASSEAVARVLETTPHGELDPVTKIKVLREEQDSIKAERVQRKQELVEKQKAEQVKTATTGLPE-DDQAPLLKGLKNEELDKFTPGLTDSATSMSETTGIQLQMSKPAPNVQPVAMKEELVTGRLKGDADITPSFVDFEKPKTPDTEEITEISAGDLAEIRSAIA---ESTPELRDETIHELKEQVAETAKLQRQAELVAAEQVSDKRKSKAALRLGSRVDRLIKEMDMMVDNLNDKRVQLLKNIEDREIHIQESTEAKE-RSKIMDEIKADQDLMVDIKDLLISLKRIRNVPDNTKWEKILKLLDEDHDGKIEMKHLLSVIELLGTENVKLSSKEIARILEMFDNE 761

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
Match: A0A4Z2DSX9 (Mitochondrial proton/calcium exchanger protein isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_008746 PE=4 SV=1)

HSP 1 Score: 385.956 bits (990), Expect = 2.416e-117
Identity = 282/716 (39.39%), Postives = 416/716 (58.10%), Query Frame = 3

Query:  309 HLFAKKFLFGHIHFGFFENNRYL--HTTVFIRCLNDKKESIEKPLGEKMLTSNEDTKGVELXXXXXXXXXXXXXXXXPLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTA---KLKAGTEERVDPKTKLEVIKEEQKVIHXXXXXXXX-----XXXXXIVLADEVLKESEDKAPIIE-LKSVESPDTAP-ISEILTVVKESDKVEIQKQDKEPKPIPVV------------------------------TEQV--IGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVK---NLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKER--YINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKE 2309
            +  A +FLF H+     ++++ +  H    I  +N KK  IE P+ E   T++ +          +  +  K+  K  LW+R+K E+VHYYHG +L   ++G+A GI  R+  GHTLTRRERKQLVRT AD+ R+VPF VFIIVPFME LLPFYLKFFPFMLPSTFK +S +   I Q+LK KLE+  FLQE + ++        D   +  F +F+K+ ++SG     +DI RFS LFED+VTL+SL+ K L+ LC+LL + TIGP  LLRFQ+ M+VRQLK +D++IA+EG+D IP WELQ L +ERGMRS G+ + +L+ QLS+WL+L LE+ VP TLLL SR +++ + L  +  L+QAI  LP + S+ A    L+      +DP TK++V++EEQ  I  ER   K       K  ++  A   L E +D+AP+++ LK+ E     P +++  T + E+  +++Q     P   PV                               TE++  I A DLA+I SAIA   E+      E I  LKE   E +K+   ++  A  +  +++  K    L S++D +I E++  V+++  +  +   + ED++  I+E    K   S     IK ++   +++ D+L S+K +    D+ KW  IL +LDED DGKIEM HL+ +I+LL +  VKL S EIA++LE+ D E
Sbjct:   51 YFSANRFLFAHV-----QDSKRIEKHIDFPIWIINPKK--IETPIPEVNNTTSSNPSVQPTSEEPNKNNNEKKITKPSLWVRIKKEIVHYYHGIRLLVLEVGIASGICFRVLGGHTLTRRERKQLVRTLADILRLVPFAVFIIVPFMELLLPFYLKFFPFMLPSTFKDKSAEANAIQQRLKAKLELTHFLQETLLQTTGAIKSDSDTPTVDEFQEFIKKVQKSGEQAQAKDITRFSKLFEDQVTLDSLDNKQLRMLCQLLSLPTIGPSHLLRFQIWMRVRQLKAEDKLIASEGVDHIPPWELQSLCQERGMRSVGLPKEKLQSQLSEWLNLHLEQNVPITLLLFSRALHVTQALVDQNPLQQAIAQLPPSASSEAVARVLETTPHGELDPVTKIKVLREEQDSIKAERVQRKQEFVEKQKAEQVKTATTGLPE-DDQAPLLKGLKNEELDKFTPGLTDSATSMSETTGIQLQISKPAPNVQPVAMKEELVTGRLKGDADITPSFVDFEKPKTPDTEEITEISAGDLAEIRSAIA---ESTPELRDETIHELKEQVAETAKLQRQAELVAAEQVSDKRKSKAALRLGSRVDRLIKEMDMMVDNLNDKRVQLLKNIEDREIHIQESTEAKE-RSKIMDEIKADQDLMVDIKDLLISLKRIRNVPDNTKWEKILKVLDEDHDGKIEMKHLLSVIELLGTENVKLSSKEIARILEMFDNE 754

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BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
Match: A0A095AGV8 (LETM1 and EF-hand domain-containing protein 1, mitochondrial OS=Schistosoma haematobium OX=6185 GN=MS3_01288 PE=4 SV=1)

HSP 1 Score: 385.185 bits (988), Expect = 5.589e-117
Identity = 267/658 (40.58%), Postives = 394/658 (59.88%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTA---KLKAGTEERVDPKTKLEVIKEEQKVIHXXXXX--------XXXXXXXXIVLADEVLKESEDKAPIIE-LKSVESPDTAPI-SEILTVVKESDKVEIQKQDKEP--------------------------------KPIPVVTEQV--IGAQDLAQIESAIA----NLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEH-----------IEVEAKKADPSEEDKK--PVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKEAI 2315
            P+WIR+KD +VHYYHGF+L   ++ +A GI  R+  GHTLTRRERKQLVRT AD+ R++PF VFIIVPFME L+PFY+KFFPFMLPSTFK +S +   I Q+LK KLE+  FLQE + ++A       D   +T F +F+K+ ++SG     +DI RFS LFED+VTL+SL+ K L+ LC+LL + TIGP  LLRFQ+ ++VRQLK +D++IANEG+D+IP WELQ L +ERGMRS G+ + +L+ QLS+WL L LEK VP TLLL SR +++ + L  +  L+QAI  LP + S+ A    L+    + +DP TK++V++EEQ  I  ER           K+ K   I+     L E  D+AP+++ LK+ E     P+ ++  T + ES   EIQ + ++P                                KP    TE+V  I A DLA+I SAIA    +L+       KE++  L++ R+  ++++++ + T   K    K+  +L S+L+ +I E++  V+            IEV     + S E K+   +++++ A              +R +++ND+L S+K ++   D  +W  IL +LDED DGKIE++H++ +I+LL S  VKL   EIA++LE+ID E +
Sbjct:  126 PMWIRIKDGIVHYYHGFRLLGLEIRIASGICFRVLGGHTLTRRERKQLVRTLADILRLLPFSVFIIVPFMEILIPFYVKFFPFMLPSTFKDKSTEANAIQQRLKAKLELTHFLQETLMQTAGALKSSSDAPTVTEFQEFIKKVQKSGEQAQAKDITRFSKLFEDQVTLDSLDNKQLRMLCRLLSLPTIGPSHLLRFQIWIRVRQLKAEDKLIANEGVDQIPPWELQSLCQERGMRSVGLPKEKLQSQLSEWLDLHLEKNVPITLLLFSRALHVTQALVDQNPLQQAIAQLPPSASSEAVARVLETTPHDELDPVTKIKVLREEQDSIKAERVQRKQELIEKQKSEKGKTIITG---LPEG-DQAPLLKGLKNEELDKVTPVLTDSATFMSES--TEIQSEIRKPVQNIQPIDTLQTSVNAKSKDDSHIDSLPVKSEKPKTSDTEEVTEISAGDLAEIHSAIAESTRHLDSETIDELKEQVAKLQQKRQ--AELVASEEVTDKRK---SKAALHLESRLERLIKEMDTMVDRLNDKRTQLLKDIEVFESHINESTESKERSKIMDQIKA------------DHDRMVDINDLLISLKRIQNIPDDTRWEKILKVLDEDHDGKIELNHILSVIELLGSENVKLSGKEIARVLEMIDNEHL 760

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Cavefish
Match: letm1 (leucine zipper and EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:103046373])

HSP 1 Score: 314.309 bits (804), Expect = 2.568e-94
Identity = 224/593 (37.77%), Postives = 356/593 (60.03%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGD-GVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESP-------DTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEE-KSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            RV DE+ HYYHGF+L + D  +A  +L R+  G+ L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ + E A +   K D G     FS F ++ R+SG     + I+RFS LFEDE+TL++L    L ALC+LL++ +IG    LRFQL MK+R ++ DD++IA EG+D + V ELQ   R RGMR+ GV E RL+ QL QWL L L + +PT+LLLLSR M+LP+TL+P +QLK  +  LP+ V+  A++K    +  +VD KTKLE + +E+  I +E    +  +     LAD   K  E +     L SV+         DTAP+ E +    + +++  ++ D        + EQ        +    + +      L + E+   L+E +KE+SK       T   KQ EE K+ K+LS +++ MI  ++K +  +E +           K V++  M      S+ +P +  E  I++N+++  ++ ++   + +K ++I   LDE+KDGKI++D ++K+++L++  ++ + ++++A+++
Sbjct:  169 RVIDEIKHYYHGFRLLWIDTTIAGRMLWRVLNGNALSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTVEEIALRN--KADKGTVTEEFSTFFQKIRDSGERPSNEQIIRFSKLFEDELTLDNLTRPQLVALCRLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLNVNELQAACRVRGMRALGVTEERLKEQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIVAKEAQVKVAELDFSKVDNKTKLETMLQEEAAILQENREKEMER-----LADAAEKAKEQQEAEAALSSVDVAIHSETLRDTAPVLEGI----KGEEITKEEIDMLSDACTKLKEQKKLLTKEKEELEELKD----DVLEYSED---LEEIKKELSK-------TGQEKQVEESKASKHLSRRVNRMIGRMDKIINELEKD-----------KLVLDGQMG-----SATTPPV-GENLISINELITVMRHIQSIPE-QKLLSIAEALDENKDGKIDIDDVMKVVELIDKEDIDINTTQVAEIM 718

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Cavefish
Match: letm1 (leucine zipper and EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:103046373])

HSP 1 Score: 313.538 bits (802), Expect = 7.099e-94
Identity = 224/602 (37.21%), Postives = 358/602 (59.47%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGD-GVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESP-------DTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEE-KSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPV---------IKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLL 2291
            RV DE+ HYYHGF+L + D  +A  +L R+  G+ L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ + E A +   K D G     FS F ++ R+SG     + I+RFS LFEDE+TL++L    L ALC+LL++ +IG    LRFQL MK+R ++ DD++IA EG+D + V ELQ   R RGMR+ GV E RL+ QL QWL L L + +PT+LLLLSR M+LP+TL+P +QLK  +  LP+ V+  A++K    +  +VD KTKLE + +E+  I +E    +  +     LAD   K  E +     L SV+         DTAP+ E +    + +++  ++ D        + EQ        +    + +      L + E+   L+E +KE+SK       T   KQ EE K+ K+LS +++ MI  ++K +  +E +           K V++  M      ++  PV         +++E  I++N+++  ++ ++   + +K ++I   LDE+KDGKI++D ++K+++L++  ++ + ++++A+++
Sbjct:  169 RVIDEIKHYYHGFRLLWIDTTIAGRMLWRVLNGNALSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTVEEIALRN--KADKGTVTEEFSTFFQKIRDSGERPSNEQIIRFSKLFEDELTLDNLTRPQLVALCRLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLNVNELQAACRVRGMRALGVTEERLKEQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIVAKEAQVKVAELDFSKVDNKTKLETMLQEEAAILQENREKEMER-----LADAAEKAKEQQEAEAALSSVDVAIHSETLRDTAPVLEGI----KGEEITKEEIDMLSDACTKLKEQKKLLTKEKEELEELKD----DVLEYSED---LEEIKKELSK-------TGQEKQVEESKASKHLSRRVNRMIGRMDKIINELEKD-----------KLVLDGQMG----SATTPPVGLFFEKRSDLQRENLISINELITVMRHIQSIPE-QKLLSIAEALDENKDGKIDIDDVMKVVELIDKEDIDINTTQVAEIM 729

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Cavefish
Match: letm2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:NCBI gene;Acc:103024686])

HSP 1 Score: 204.912 bits (520), Expect = 4.462e-57
Identity = 152/270 (56.30%), Postives = 192/270 (71.11%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            RV DEL HYYHGF+L   D  +A  ++ RL  G  LTRRER++L+RT AD+ R+VPF+VFIIVPFMEFLLP +LK FP MLPSTF+TESK +E   + L  KLE+AKFLQE IAE A + K   GD  +   FS +++Q R +G    T+DI++FS LFEDE+TLE L    L ALCKLL++  IG   LLRFQL M++R +K DD+MI+ EG+  + V ELQ  SR RGMRS G+  ++LR QL QWL L L++ VP +LLLLSR MYL
Sbjct:  117 RVLDELKHYYHGFRLLGIDTKIAGRMVWRLLHGQQLTRRERRRLMRTCADLFRLVPFMVFIIVPFMEFLLPVFLKLFPEMLPSTFETESKKEEKQKKGLAAKLELAKFLQETIAEMARRNKAAVGD--ETQQFSTYVQQVRHTGEQPTTKDIVKFSKLFEDELTLEHLERPQLVALCKLLELQPIGTNNLLRFQLMMQLRTIKTDDEMISKEGVAAMTVAELQAASRSRGMRSLGLTTDQLRQQLQQWLDLHLKENVPPSLLLLSRAMYL 384

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000480.1 (pep scaffold:Pmarinus_7.0:GL485460:9771:10305:1 gene:ENSPMAG00000000433.1 transcript:ENSPMAT00000000480.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 87.0409 bits (214), Expect = 1.090e-20
Identity = 58/93 (62.37%), Postives = 69/93 (74.19%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESK 815
            L  RV  EL HYYHGF+L   D  VA  I+ ++  G  L RRER+QL+RT AD+ R++PFLVFIIVPFMEFLLP +LK FP MLPSTF+T SK
Sbjct:   19 LGARVVAELRHYYHGFRLLGIDTRVAARIVWQILHGSQLNRRERRQLLRTCADLFRLLPFLVFIIVPFMEFLLPVFLKLFPNMLPSTFETLSK 111

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Yeast
Match: MDM38 (Mitochondrial protein; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome [Source:SGD;Acc:S000005387])

HSP 1 Score: 138.658 bits (348), Expect = 1.149e-34
Identity = 99/277 (35.74%), Postives = 161/277 (58.12%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAK----FLQEAIAESA--TKKTIKGDGVDLTTFSDFMKQ---ARESG-LTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLS 1337
            L ++VK  L HY +G KL  +++ V+  +L +  +G+ L+RRER QL RT  D+ R++PF  F+I+PF E  LPF LK FP +LPST+++  KDK+    KL   +EI K    FL E + ES   T  TI+ +      F +F ++   A+E   +T    +I   + +F+++  L++L+   L A+ K + +   G   +LR+Q+  K++ +  DD+ I  EG++ +   EL Q    RGM++YGV++  L   L  WL L L +K+P+ L++LS
Sbjct:   83 LMVKVKHALKHYANGTKLLGYEIKVSTKLLIKFAQGYELSRRERNQLRRTMGDVFRLIPFSAFLIIPFAELFLPFALKLFPNLLPSTYES-GKDKQAKRNKL---IEIRKKTSEFLHETLEESNLITYNTIE-NAEKKQKFLNFFRKLYSAKEGKIMTFQHDEISAIAQMFKNDSVLDNLSRPQLAAMSKFMSLRPFGNDNMLRYQIRSKLKDIMNDDKTIDYEGVESLSQEELYQACVSRGMKAYGVSKEDLVDNLKVWLELRLRQKIPSVLMVLS 354

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Yeast
Match: YLH47 (Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome [Source:SGD;Acc:S000006329])

HSP 1 Score: 136.346 bits (342), Expect = 1.408e-34
Identity = 112/381 (29.40%), Postives = 196/381 (51.44%), Query Frame = 3

Query:  534 PLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVD---LTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPE---EQLKQAILVLPKTVSNTAKLKAGTEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTV 1658
            P  ++++  L HY+ G KL   ++ ++  +L +   G+ LTRRE  QL RT+ D+ R+VPF  F+I+PF E LLPF LK FP +LPST+++ SK +E  L+ L+      K + E I  +  K   K + +       F+ F    R +G+    Q ++  + LF D+  L+++   YL AL K +++   G   +LR+++  K+ +LK DD  I  E  +++ + EL+     RG+RS  V  + L   L  WL++ L+ K+P+TLL+++         + E   + L   ++ +P  + +  K+    E+    K KL   K+ ++     +E  +  + A + + DE+  + +DK        V+  DT PI E   +
Sbjct:   80 PFKVKMQKALRHYWDGSKLLGLEIKISSKLLMKSAAGYPLTRRENLQLKRTTQDIVRLVPFAAFLIIPFAELLLPFALKLFPNLLPSTYES-SKKRENKLENLRN---TRKLMSEIIKNN--KSHFKPNNISEEQKALFNRFYTHVRATGVPESRQQLIEVARLFTDDTVLDNVTRPYLIALAKYMNLQPFGTDVMLRYRIRYKMLELKKDDLSIYYEDAEQLSLSELKTACASRGIRSVDVEPSVLYSNLRLWLNMRLKDKIPSTLLIMATAYNYGNVQSKESLYDALCDVLIGIPDELYHEVKVNVVKEDEASAKQKL---KQLREQEEIMKEEEQQEENAIVSVKDELSLDDQDKNIDAAAPDVKPHDTKPIGEAAAI 451

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Nematostella
Match: EDO43248 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZB3])

HSP 1 Score: 268.47 bits (685), Expect = 9.169e-80
Identity = 157/331 (47.43%), Postives = 228/331 (68.88%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESA-TKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLS-----QWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAG--TEERVDPKTKLEVIK-EEQKV 1502
            LW +VK E VHYY+GFKL +F+  ++  +L ++  G +LTRRER+Q +RT ADM R+VPFLVF+++PFMEFLLP  +K FP MLPSTF+ +SK +E   ++LKGK+E+AKFLQ+ + E A T K  K  G  + +F++F  + R  G     +DIL+FS LFEDE+TL++++   LKA+  LL + + G    LRFQL+MK+RQL+ DD MI  EG+D + V ELQ   + RGMR+ GV E RLR+ L+     QWL L L+++VP +LLL+SR +YLPET++  ++LK+ +  LP  +    ++K    + E VD K +LE+++ EEQK+
Sbjct:    8 LWEKVKHEAVHYYNGFKLLYFETRISLRLLWQVMNGKSLTRRERRQFLRTVADMFRLVPFLVFLVIPFMEFLLPVAVKLFPNMLPSTFEDKSKKEEARRKELKGKIELAKFLQDTVEEMAVTAKQKKNQGA-VVSFANFFDKIRTRGEQPSNEDILKFSKLFEDEITLDNMSRGQLKAINGLLLLPSYGTNNYLRFQLQMKLRQLRTDDLMIKKEGVDSLNVQELQSACQARGMRAIGVPEARLRFFLTLVFILQWLELHLDEEVPISLLLMSRALYLPETVSNVDKLKETLSKLPNNLVGETEVKLAELSGELVDNKLRLEILRLEEQKI 337

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Nematostella
Match: EDO28252 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T702])

HSP 1 Score: 135.191 bits (339), Expect = 1.199e-36
Identity = 71/148 (47.97%), Postives = 103/148 (69.59%), Query Frame = 3

Query:  987 TQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLS-----QWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTV 1415
             +DIL+FS LFEDE+TL++++   LKA+  LL + + G    LRFQL+MK+RQL+ DD MI  EG+D + V ELQ   + RGMR+ GV E RLR+ L+     QWL L L+++VP +LLL+SR +YLPET++  ++LK+ +  LP  +
Sbjct:    6 NEDILKFSKLFEDEITLDNMSRGQLKAINGLLLLPSYGTNNYLRFQLQMKLRQLRTDDLMIKKEGVDSLNVQELQSACQARGMRAIGVPEARLRFFLTLVFILQWLELHLDEEVPISLLLMSRALYLPETVSNVDKLKETLSKLPNNL 153

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
Match: letm1 (leucine zipper and EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:101165019])

HSP 1 Score: 320.857 bits (821), Expect = 1.502e-96
Identity = 228/620 (36.77%), Postives = 362/620 (58.39%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXX-----------XIVLADEVLKESEDKAPIIELKSVESP----DTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAK---------TLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIK-----KERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKE 2309
            RV DE+ HYYHGFKL + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I++FS LFEDE+TL++L    L ALC+LL++ +IG    LRFQL MK+R ++ DD++IA EG+  + V E+Q   R RGMR+ GV E RLR QL QWL L L +++PT+LLLLSR MYLP+TL+P +QLK  +  LP+ V+  A+LK    E  +VD KTKLE + +E+  I ++ +  +  + A           E+ LA    + SE +   ++           DTAP+ + L +     +  ++ QD+E           I  +++  +  A + L+E K             K+++    E  +EI K  S S +   ++  E K+ K LS ++  MI  I+K +  +          E DK      V+    +DS  +P +      +E  I++ +++  ++ ++   + EK + I   LD++KDGK+++D ++K+++L++  ++ + +S++A ++ ++ KE
Sbjct:  166 RVVDEIWHYYHGFKLLWIDTTIAGRMLWRILNGHPLSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKAAKGNVTE--EFSTFFQKIRDSGERPSNEQIIKFSKLFEDELTLDNLTRPQLVALCRLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVKSLNVNEVQAACRVRGMRALGVTEERLREQLGQWLELHLNQQIPTSLLLLSRAMYLPDTLSPADQLKTTLQTLPEMVTKEAQLKVAEMELSKVDNKTKLETMLQEEAAIRQDTKDREMERLADAAEKAAKEEGELELAASRARYSEAETASLKANGASHSETLRDTAPVVDGLKL-----QTYLRFQDEE-----------ITKEEIDLLSDACSKLKEQKRLLTLEKEELEDLKDDVQEYNEDLEEIKKEFSKSGQEKAIE--ESKASKRLSKRVTRMIGRIDKIITEL----------ENDK------VILDGQVDSGATPPVGLFYTFRENLISITELINVMRQIQNIPE-EKLLRIAEALDDNKDGKVDIDDVIKVVELIDKEDIDVSTSQVADIMVMLQKE 748

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
Match: letm1 (leucine zipper and EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:101165019])

HSP 1 Score: 319.701 bits (818), Expect = 5.650e-96
Identity = 225/615 (36.59%), Postives = 360/615 (58.54%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXX-----------XIVLADEVLKESEDKAPIIELKSVESP----DTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAK---------TLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKE 2309
            RV DE+ HYYHGFKL + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I++FS LFEDE+TL++L    L ALC+LL++ +IG    LRFQL MK+R ++ DD++IA EG+  + V E+Q   R RGMR+ GV E RLR QL QWL L L +++PT+LLLLSR MYLP+TL+P +QLK  +  LP+ V+  A+LK    E  +VD KTKLE + +E+  I ++ +  +  + A           E+ LA    + SE +   ++           DTAP+ + L +     +  ++ QD+E           I  +++  +  A + L+E K             K+++    E  +EI K  S S +   ++  E K+ K LS ++  MI  I+K +  +E +    D   +        +   K  D++      +E  I++ +++  ++ ++   + EK + I   LD++KDGK+++D ++K+++L++  ++ + +S++A ++ ++ KE
Sbjct:  166 RVVDEIWHYYHGFKLLWIDTTIAGRMLWRILNGHPLSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKAAKGNVTE--EFSTFFQKIRDSGERPSNEQIIKFSKLFEDELTLDNLTRPQLVALCRLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVKSLNVNEVQAACRVRGMRALGVTEERLREQLGQWLELHLNQQIPTSLLLLSRAMYLPDTLSPADQLKTTLQTLPEMVTKEAQLKVAEMELSKVDNKTKLETMLQEEAAIRQDTKDREMERLADAAEKAAKEEGELELAASRARYSEAETASLKANGASHSETLRDTAPVVDGLKL-----QTYLRFQDEE-----------ITKEEIDLLSDACSKLKEQKRLLTLEKEELEDLKDDVQEYNEDLEEIKKEFSKSGQEKAIE--ESKASKRLSKRVTRMIGRIDKIITELENDKVILDGQVDSGATPPVGLFLTKYSDATSLFYTFRENLISITELINVMRQIQNIPE-EKLLRIAEALDDNKDGKVDIDDVIKVVELIDKEDIDVSTSQVADIMVMLQKE 759

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
Match: letm1 (leucine zipper and EF-hand containing transmembrane protein 1 [Source:NCBI gene;Acc:101165019])

HSP 1 Score: 319.316 bits (817), Expect = 7.598e-96
Identity = 222/601 (36.94%), Postives = 361/601 (60.07%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATK-KTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEE--RVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKP-IPVVTEQVIGAQDLAQIESAIANLEEAK---------TLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKE 2309
            RV DE+ HYYHGFKL + D  +A  +L R+  GH L+RRER+Q +RT AD+ R++PFLVFIIVPFMEFLLP  LK FP MLPSTF+T+SK +E + ++L+ KLE+AKFLQ+ I E A + K  KG+  +   FS F ++ R+SG     + I++FS LFEDE+TL++L    L ALC+LL++ +IG    LRFQL MK+R ++ DD++IA EG+  + V E+Q   R RGMR+ GV E RLR QL QWL L L +++PT+LLLLSR MYLP+TL+P +QLK  +  LP+ V+  A+LK    E  +VD KTKLE + +E+  I ++ +  +  +     LAD   K ++++   +EL    +   A  SE  T   +++     +  ++  P +  + ++ I  +++  +  A + L+E K             K+++    E  +EI K  S S +   ++  E K+ K LS ++  MI  I+K +  +E +    D   +        +   K  D++      +E  I++ +++  ++ ++   + EK + I   LD++KDGK+++D ++K+++L++  ++ + +S++A ++ ++ KE
Sbjct:  166 RVVDEIWHYYHGFKLLWIDTTIAGRMLWRILNGHPLSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKAAKGNVTE--EFSTFFQKIRDSGERPSNEQIIKFSKLFEDELTLDNLTRPQLVALCRLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVKSLNVNEVQAACRVRGMRALGVTEERLREQLGQWLELHLNQQIPTSLLLLSRAMYLPDTLSPADQLKTTLQTLPEMVTKEAQLKVAEMELSKVDNKTKLETMLQEEAAIRQDTKDREMER-----LADAAEKAAKEEG-ELEL----AASRARYSEAETASLKANGASHSETLRDTAPVVDGLKDEEITKEEIDLLSDACSKLKEQKRLLTLEKEELEDLKDDVQEYNEDLEEIKKEFSKSGQEKAIE--ESKASKRLSKRVTRMIGRIDKIITELENDKVILDGQVDSGATPPVGLFLTKYSDATSLFYTFRENLISITELINVMRQIQNIPE-EKLLRIAEALDDNKDGKVDIDDVIKVVELIDKEDIDVSTSQVADIMVMLQKE 751

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
Match: letm2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:NCBI gene;Acc:101174432])

HSP 1 Score: 201.445 bits (511), Expect = 7.391e-56
Identity = 150/273 (54.95%), Postives = 193/273 (70.70%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTT-FSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            L+ RV DEL HYY+GF+L   D+ +A  ++ RL  G  LTRRER++L+RT AD+ R+VPF+VFIIVPFMEFLLP +LK FP MLPSTF+TESK +E   + L  KLE+AKFLQE I+E A +   K    D T  FS ++++ R +G    T+DI+RFS LFEDE+TLE L    L ALCKLL++  IG   LLRFQL MK+R ++ DD+MI+ EG+  + V ELQ   R RGMRS G+  ++LR QL QWL L L++ VP +LLLLSR MYL
Sbjct:  145 LYQRVVDELKHYYNGFRLLGIDIKIAGRMVWRLLHGQLLTRRERRRLLRTCADLFRLVPFIVFIIVPFMEFLLPVFLKLFPEMLPSTFETESKKEEKQKKGLAAKLELAKFLQETISEMALRNRAKAQTEDETQRFSKYVQEVRGTGEQPTTKDIVRFSKLFEDELTLEHLERPQLVALCKLLELQPIGTNNLLRFQLMMKLRGIRSDDEMISAEGVAALSVSELQAACRSRGMRSLGLTTDQLRQQLQQWLDLHLKENVPPSLLLLSRAMYL 417

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
Match: letm2 (leucine zipper and EF-hand containing transmembrane protein 2 [Source:NCBI gene;Acc:101174432])

HSP 1 Score: 202.216 bits (513), Expect = 8.229e-56
Identity = 150/273 (54.95%), Postives = 193/273 (70.70%), Query Frame = 3

Query:  537 LWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTT-FSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYL 1352
            L+ RV DEL HYY+GF+L   D+ +A  ++ RL  G  LTRRER++L+RT AD+ R+VPF+VFIIVPFMEFLLP +LK FP MLPSTF+TESK +E   + L  KLE+AKFLQE I+E A +   K    D T  FS ++++ R +G    T+DI+RFS LFEDE+TLE L    L ALCKLL++  IG   LLRFQL MK+R ++ DD+MI+ EG+  + V ELQ   R RGMRS G+  ++LR QL QWL L L++ VP +LLLLSR MYL
Sbjct:  145 LYQRVVDELKHYYNGFRLLGIDIKIAGRMVWRLLHGQLLTRRERRRLLRTCADLFRLVPFIVFIIVPFMEFLLPVFLKLFPEMLPSTFETESKKEEKQKKGLAAKLELAKFLQETISEMALRNRAKAQTEDETQRFSKYVQEVRGTGEQPTTKDIVRFSKLFEDELTLEHLERPQLVALCKLLELQPIGTNNLLRFQLMMKLRGIRSDDEMISAEGVAALSVSELQAACRSRGMRSLGLTTDQLRQQLQQWLDLHLKENVPPSLLLLSRAMYL 417

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Planmine SMEST
Match: SMESG000064220.1 (SMESG000064220.1)

HSP 1 Score: 1315.83 bits (3404), Expect = 0.000e+0
Identity = 708/711 (99.58%), Postives = 710/711 (99.86%), Query Frame = 3

Query:  225 MNLKYIIRNAGFSAVLFSPSRKIVNNKNHLFAKKFLFGHIHFGFFENNRYLHTTVFIRCLNDKKESIEKPLGEKMLTSNEDTKGVELXXXXXXXXXXXXXXXXPLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKEAIIAETKKDPTPNENQ 2357
            MNLKYIIRNAGFSA+LFSPSRKIVNNKNHLFAKKFLFGHIHFGFFENNRYLHTTVFIRCLNDKKESIEKPLGEKMLTSNEDTKGVELKSSSS+TSISKEKVKKPLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEFLLPFYLKFFPFMLPSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEERVDPKTKLEVIKEEQKVIHEEREASKASKEAEIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYI VNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKEAIIAETKKDPTPNENQ
Sbjct:    1 MNLKYIIRNAGFSAILFSPSRKIVNNKNHLFAKKFLFGHIHFGFFENNRYLHTTVFIRCLNDKKESIEKPLGEKMLTSNEDTKGVELKSSSSSTSISKEKVKKPLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEFLLPFYLKFFPFMLPSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKAGTEERVDPKTKLEVIKEEQKVIHEEREASKASKEAEIVLADEVLKESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYIKVNDVLESIKSLEKTGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKEAIIAETKKDPTPNENQ 711

[Close]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Planmine SMEST
Match: SMESG000055346.1 (SMESG000055346.1)

HSP 1 Score: 441.425 bits (1134), Expect = 3.091e-143
Identity = 272/591 (46.02%), Postives = 387/591 (65.48%), Query Frame = 3

Query:  546 RVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQLVRTSADMARMVPFLVFIIVPFMEXXXXXXXXXXXXXXXSTFKTESKDKEFILQKLKGKLEIAKFLQEAIAES-ATKKTIKGDGVDLTTFSDFMKQARESGLTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQLEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQLSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNTAKLKA-GTEERVDPKTKLEVIKEEQKVIHXXXXXXXXXXXXXIVLADEVLKESED--KAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVVTEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSDETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKPVIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEK-TGDHEKWVTILSLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVID 2303
            ++K+E VHYYHGF+LF+ ++G+  GIL RL+ G TLTRRERKQLVRT AD+ R+ PF+VFI VPF+E LLP Y++FFPFM+PSTF+  SKD E   Q LK KLE+AKFLQ+ + E+ +  K      V L +F+ FMKQ RESG T +T DIL+FS LFEDEVTLESL+ + LKALCKLL+I ++GP A L F L +KV  LK+DD+MIA EGIDK+P +ELQQ+ RERGMR+ GV+E RLR+QLSQWL LS+EK+VP +LLLLSR MYLP+ L+PE+QL +AIL LP+ VS  A L++  T+ + D KTK E++ EEQK+I +E+             ADE  KES+   K  +I        DTA I     V  E DK      D + K    ++E+ I   DL QIE+AI ++    T + +EE+  LKE   E+   + T           +K    L+ KL+ MI+E++  ++ ++V+          ++ +I ++   ++ +++      +ER + ++D++ ++K L+  +GD EKW  IL++LDEDKDG IE+ H+ +++ +L S EVKL S ++ +L++ ID
Sbjct:  145 KIKNECVHYYHGFRLFYLEVGITGGILYRLSSGRTLTRRERKQLVRTVADLVRLAPFVVFIAVPFLELLLPLYIRFFPFMMPSTFQHSSKDTEKTRQLLKCKLEMAKFLQDTLEETRSINKYSSEASVTLESFNLFMKQVRESGQTANTDDILKFSRLFEDEVTLESLDHRQLKALCKLLEIQSVGPKAFLSFHLRIKVHMLKIDDRMIAREGIDKLPAFELQQICRERGMRAVGVSEERLRFQLSQWLKLSIEKQVPISLLLLSRTMYLPDQLSPEQQLTKAILHLPEVVSKEASLRSVRTDNKFDNKTKWELMSEEQKLIAKEQ-------------ADE--KESQRIVKETLI--------DTAAI-----VAVEKDK----PLDVDSKR-SAISEESISTSDLNQIENAIESISNNNTAWQEEELDELKEQAAELHDQVET-----------KKGSNRLNKKLNNMIEEMDSLLDRLKVK----------QENIIHDIKVGQTSETA------EERVVAISDLMNALKQLKSASGDDEKWQRILTVLDEDKDGHIELHHMTEILDMLGSEEVKLSSKDMGRLIDAID 675

The following BLAST results are available for this feature:

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Celegans
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Fly
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Mouse
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Cavefish
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Sea Lamprey
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Yeast
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Nematostella
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Planmine SMEST

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
LETM1	1.879e-88	38.27	leucine zipper and EF-hand containing transmembran...	[more]
LETM2	9.627e-56	51.48	leucine zipper and EF-hand containing transmembran...	[more]
LETM2	2.668e-55	51.48	leucine zipper and EF-hand containing transmembran...	[more]
LETM2	1.148e-42	39.26	leucine zipper and EF-hand containing transmembran...	[more]
LETM2	5.127e-42	39.26	leucine zipper and EF-hand containing transmembran...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
letm-1	4.793e-77	36.48	LETM1 (Leucine zipper, EF-hand, TransMembrane mito...	[more]
letm-1	6.360e-77	36.48	LETM1 (Leucine zipper, EF-hand, TransMembrane mito...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Letm1	4.891e-75	47.10	gene:FBgn0284252 transcript:FBtr0072349	[more]
Letm1	4.891e-75	47.10	gene:FBgn0284252 transcript:FBtr0072348	[more]
Letm1	4.891e-75	47.10	gene:FBgn0284252 transcript:FBtr0072347	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
letm1	1.322e-99	38.63	leucine zipper-EF-hand containing transmembrane pr...	[more]
letm1	3.267e-99	38.31	leucine zipper-EF-hand containing transmembrane pr...	[more]
letm1	2.855e-98	37.99	leucine zipper-EF-hand containing transmembrane pr...	[more]
letm2	6.854e-57	50.31	leucine zipper-EF-hand containing transmembrane pr...	[more]
letm2	3.695e-42	39.69	leucine zipper-EF-hand containing transmembrane pr...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
anapc1	1.646e-95	38.59	anaphase promoting complex subunit 1 [Source:Xenba...	[more]
anapc1	4.339e-95	38.23	anaphase promoting complex subunit 1 [Source:Xenba...	[more]
anapc1	6.087e-95	39.03	anaphase promoting complex subunit 1 [Source:Xenba...	[more]
anapc1	1.951e-93	38.50	anaphase promoting complex subunit 1 [Source:Xenba...	[more]
anapc1	1.055e-92	38.23	anaphase promoting complex subunit 1 [Source:Xenba...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Letm1	3.382e-87	37.25	leucine zipper-EF-hand containing transmembrane pr...	[more]
Letm2	3.786e-55	50.74	leucine zipper-EF-hand containing transmembrane pr...	[more]
Letm2	2.105e-16	50.32	leucine zipper-EF-hand containing transmembrane pr...	[more]
Letm2	2.071e-11	57.73	leucine zipper-EF-hand containing transmembrane pr...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5ZK33\|LETM1_CHICK	2.057e-101	39.13	Mitochondrial proton/calcium exchanger protein OS=...	[more]
sp\|Q0VCA3\|LETM1_BOVIN	2.607e-100	37.83	Mitochondrial proton/calcium exchanger protein OS=...	[more]
sp\|Q1LY46\|LETM1_DANRE	9.982e-99	38.63	Mitochondrial proton/calcium exchanger protein OS=...	[more]
sp\|Q0VA06\|LETM1_XENTR	1.399e-94	38.92	Mitochondrial proton/calcium exchanger protein OS=...	[more]
sp\|O95202\|LETM1_HUMAN	9.025e-88	38.27	Mitochondrial proton/calcium exchanger protein OS=...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4S2LGI3	4.740e-121	39.88	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
A0A4S2LFQ1	5.790e-119	39.59	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
C1LG65	3.021e-118	39.25	Leucine zipper-EF-hand-containing transmembrane pr...	[more]
A0A4Z2DSX9	2.416e-117	39.39	Mitochondrial proton/calcium exchanger protein iso...	[more]
A0A095AGV8	5.589e-117	40.58	LETM1 and EF-hand domain-containing protein 1, mit...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
letm1	2.568e-94	37.77	leucine zipper and EF-hand containing transmembran...	[more]
letm1	7.099e-94	37.21	leucine zipper and EF-hand containing transmembran...	[more]
letm2	4.462e-57	56.30	leucine zipper and EF-hand containing transmembran...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000000480.1	1.090e-20	62.37	pep scaffold:Pmarinus_7.0:GL485460:9771:10305:1 ge...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
MDM38	1.149e-34	35.74	Mitochondrial protein; forms a complex with Mba1p ...	[more]
YLH47	1.408e-34	29.40	Mitochondrial inner membrane protein; exposed to t...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO43248	9.169e-80	47.43	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO28252	1.199e-36	47.97	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
letm1	1.502e-96	36.77	leucine zipper and EF-hand containing transmembran...	[more]
letm1	5.650e-96	36.59	leucine zipper and EF-hand containing transmembran...	[more]
letm1	7.598e-96	36.94	leucine zipper and EF-hand containing transmembran...	[more]
letm2	7.391e-56	54.95	leucine zipper and EF-hand containing transmembran...	[more]
letm2	8.229e-56	54.95	leucine zipper and EF-hand containing transmembran...	[more]

BLAST of LETM1 and EF-hand domain-containing protein 1, mitochondrial vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000064220.1	0.000e+0	99.58	SMESG000064220.1	[more]
SMESG000055346.1	3.091e-143	46.02	SMESG000055346.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033722 ID=SMED30033722|Name=LETM1 and EF-hand domain-containing protein 1, mitochondrial|organism=Schmidtea mediterranea sexual|type=transcript|length=2713bp
TTATCAATGTCCGTATAAATAATGCAAATAGTTAAATTTTTGTTAAATTT
GTTCGAACTTAAGTAACTCAAAAATTTAGAGTTGCTTAATATAAAGTTTC
GTAAATGCCTATTTATTACTAATTTAATTTTAAATCACATAGAAATTTTC
TGCTTCTAAAAGTTTTTCTTCAAAAAATAAACATTATTTTTCAGATTACT
TATTTATTTTTAAGAATTTCTAAAATGAATTTAAAGTACATAATCAGAAA
TGCTGGATTCTCGGCTGTATTATTTTCACCATCTCGAAAAATTGTAAATA
ATAAAAATCATTTATTCGCAAAGAAATTTTTATTTGGACATATCCATTTC
GGATTTTTTGAAAACAATCGATATTTACATACTACTGTGTTTATTAGATG
TTTAAATGACAAAAAAGAAAGCATTGAGAAACCATTGGGTGAAAAGATGT
TGACATCAAATGAAGACACCAAAGGTGTTGAATTAAAATCATCGTCTTCT
ACAACCAGTATTTCAAAAGAAAAGGTTAAGAAACCTTTATGGATTAGAGT
TAAAGATGAATTAGTGCATTACTATCATGGTTTTAAATTATTTTTCTTTG
ATCTTGGAGTTGCTTGTGGAATTTTAAAAAGACTTACCAAGGGACATACT
CTAACAAGACGGGAAAGGAAACAGTTAGTTAGAACATCAGCTGATATGGC
CAGGATGGTTCCATTTTTAGTATTCATTATTGTACCGTTCATGGAGTTCC
TCTTACCATTTTATTTGAAATTTTTTCCGTTTATGTTACCCAGTACTTTC
AAAACCGAATCTAAAGACAAAGAATTCATACTTCAAAAACTGAAAGGAAA
ACTAGAAATCGCGAAATTCTTACAAGAAGCCATTGCTGAAAGTGCGACGA
AAAAGACAATTAAAGGGGATGGCGTAGATTTGACTACATTCAGTGATTTT
ATGAAACAGGCTAGAGAATCGGGTCTTACTGTTGACACGCAAGATATTTT
GCGATTTTCACATTTGTTTGAAGATGAAGTCACCTTAGAGTCGTTAAATC
CAAAATATTTGAAAGCCCTTTGTAAACTTTTGGATATTAATACTATTGGA
CCACCTGCATTATTGAGATTTCAATTGGAAATGAAAGTACGACAATTAAA
AGTTGATGATCAGATGATTGCAAATGAAGGTATTGATAAAATTCCTGTAT
GGGAATTACAACAATTATCTCGAGAAAGAGGAATGAGATCTTATGGTGTT
AATGAAAATCGTTTACGATATCAGCTATCTCAGTGGCTTAGTCTAAGTCT
GGAAAAAAAGGTTCCTACAACACTTCTATTATTATCAAGGGTAATGTATT
TACCAGAAACTCTGACTCCAGAGGAACAGCTGAAACAAGCCATTCTTGTG
TTGCCTAAGACAGTTTCAAATACAGCGAAACTTAAAGCTGGCACTGAAGA
ACGAGTTGATCCTAAAACTAAATTAGAAGTTATCAAAGAAGAGCAAAAAG
TTATCCACGAAGAAAGGGAAGCCAGTAAAGCATCGAAAGAAGCTGAAATT
GTTTTGGCAGATGAAGTTTTAAAGGAATCTGAAGATAAAGCTCCAATAAT
AGAACTAAAATCAGTTGAAAGCCCTGATACTGCCCCAATTTCCGAAATTC
TCACAGTAGTTAAAGAATCCGATAAAGTCGAAATTCAAAAACAAGATAAA
GAACCTAAACCTATCCCTGTTGTAACGGAACAAGTGATAGGTGCTCAAGA
TCTTGCTCAAATCGAATCAGCTATTGCTAATCTTGAAGAGGCCAAAACCT
TATTCCATAAAGAAGAAATTGGTGTTTTGAAAGAAAGCAGAAAAGAAATT
TCTAAAATTTTAAGCACATCTGATGAAACTGCACCAGTAAAACAACCAGA
GGAAAAATCTGTTAAGAATTTATCCAGTAAACTTGATGAGATGATTGATG
AAATTGAAAAAACTGTGGAACACATTGAAGTGGAAGCTAAAAAAGCTGAT
CCCAGCGAAGAGGACAAAAAGCCAGTGATAGAAGAAGTTATGGCAGTGAA
ATCAATTGATAGTAGTCCATCTCCGGTTATCAAAAAAGAACGTTACATAA
ATGTAAATGATGTTCTGGAAAGTATTAAGAGTCTTGAGAAAACTGGTGAT
CATGAGAAATGGGTGACAATTCTGTCTTTATTGGATGAAGATAAAGATGG
GAAAATAGAAATGGACCATTTGGTGAAAATGATCAAATTGTTGAATTCGA
TTGAAGTTAAGCTGCCTTCCTCAGAAATCGCTAAACTTCTGGAGGTTATT
GATAAAGAAGCAATAATTGCTGAGACGAAAAAAGATCCAACACCTAATGA
GAATCAATAAAAGTTTTAGGAATGATTTTGTGTAGCATCGTAATTTATTT
GAATAAACTTAGAATTAATTACTATGAATACAATTTATACAAATTGATGT
TTTCAGTTGGTACTTTTGGTAACGCCTGCAAATGAGTTGTTGAGATTTCC
TTTCCCTCTATCCGAGTATGGCATTTGTTTTGGCAAAAATTATATTGATT
GAATTTGACATGAAAAGAAATCAGTGGTGAAAATTAAAATAAGTTCTTAA
TATTAAAATTAATATTGATCGCATTTCATAAATACATTCCAAATTTGCTA
GGTTATTAAATAGCTTCGGTGAGCAATGGAATATATTCTGAATCTACTTG
GCCTTTGTGAAAT

protein sequence of SMED30033722-orf-1

>SMED30033722-orf-1 ID=SMED30033722-orf-1|Name=SMED30033722-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=712bp
MNLKYIIRNAGFSAVLFSPSRKIVNNKNHLFAKKFLFGHIHFGFFENNRY
LHTTVFIRCLNDKKESIEKPLGEKMLTSNEDTKGVELKSSSSTTSISKEK
VKKPLWIRVKDELVHYYHGFKLFFFDLGVACGILKRLTKGHTLTRRERKQ
LVRTSADMARMVPFLVFIIVPFMEFLLPFYLKFFPFMLPSTFKTESKDKE
FILQKLKGKLEIAKFLQEAIAESATKKTIKGDGVDLTTFSDFMKQARESG
LTVDTQDILRFSHLFEDEVTLESLNPKYLKALCKLLDINTIGPPALLRFQ
LEMKVRQLKVDDQMIANEGIDKIPVWELQQLSRERGMRSYGVNENRLRYQ
LSQWLSLSLEKKVPTTLLLLSRVMYLPETLTPEEQLKQAILVLPKTVSNT
AKLKAGTEERVDPKTKLEVIKEEQKVIHEEREASKASKEAEIVLADEVLK
ESEDKAPIIELKSVESPDTAPISEILTVVKESDKVEIQKQDKEPKPIPVV
TEQVIGAQDLAQIESAIANLEEAKTLFHKEEIGVLKESRKEISKILSTSD
ETAPVKQPEEKSVKNLSSKLDEMIDEIEKTVEHIEVEAKKADPSEEDKKP
VIEEVMAVKSIDSSPSPVIKKERYINVNDVLESIKSLEKTGDHEKWVTIL
SLLDEDKDGKIEMDHLVKMIKLLNSIEVKLPSSEIAKLLEVIDKEAIIAE
TKKDPTPNENQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000204	ovary
PLANA:0000208	testis
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR011992	EF-hand-dom_pair
IPR011685	LETM1
IPR033122	LETM1_RBD
IPR002048	EF_hand_dom

Vocabulary: **molecular function**
Term	Definition
GO:0043022	ribosome binding
GO:0005509	calcium ion binding

Vocabulary: **cellular component**
Term	Definition
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **biological process**
Term	Definition
GO:0006875	cellular metal ion homeostasis
GO:0042407	cristae formation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 510..530
None	No IPR available	COILS	Coil	Coil	coord: 563..587
None	No IPR available	PANTHER	PTHR14009:SF1	MITOCHONDRIAL PROTON/CALCIUM EXCHANGER PROTEIN	coord: 86..584
None	No IPR available	PANTHER	PTHR14009	LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN	coord: 86..584
None	No IPR available	TMHMM	TMhelix		coord: 162..184
IPR011685	LETM1-like	PFAM	PF07766	LETM1	coord: 106..371 e-value: 6.0E-92 score: 307.8
IPR033122	Letm1 ribosome-binding domain	PROSITE	PS51758	LETM1_RBD	coord: 204..423 score: 23.621
IPR002048	EF-hand domain	PROSITE	PS50222	EF_HAND_2	coord: 641..676 score: 10.05
IPR011992	EF-hand domain pair	SUPERFAMILY	SSF47473	EF-hand	coord: 623..694