RRM domain-containing protein

Overview
NameRRM domain-containing protein
Smed IDSMED30033721
Length (bp)2486
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of RRM domain-containing protein (SMED30033721) t-SNE clustered cells

Violin plots show distribution of expression levels for RRM domain-containing protein (SMED30033721) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RRM domain-containing protein (SMED30033721) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RRM domain-containing protein (SMED30033721) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30033721

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30033721SMESG000019202.1 SmedASXL_010580SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
neuronSMED30033721SMESG000019202.1 dd_Smed_v4_37545_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30033721SMESG000019202.1 dd_Smed_v6_37545_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30033721SMESG000019202.1 OX_Smed_1.0.16860ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
reproductive organSMED30033721SMESG000019202.1 Contig41290newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30033721SMESG000019202.1 Contig41290uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Celegans
Match: deg-1 (Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:P24585])

HSP 1 Score: 55.8398 bits (133), Expect = 1.239e-7
Identity = 27/60 (45.00%), Postives = 42/60 (70.00%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKK 2246
            +QL  E+ +ES +Y + NL++D GG LGL+LGFSV++++E+  L V +I   F S  E+K
Sbjct:  687 EQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEEK 746
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Celegans
Match: deg-1 (Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:P24585])

HSP 1 Score: 55.8398 bits (133), Expect = 1.239e-7
Identity = 27/60 (45.00%), Postives = 42/60 (70.00%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKK 2246
            +QL  E+ +ES +Y + NL++D GG LGL+LGFSV++++E+  L V +I   F S  E+K
Sbjct:  687 EQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEEK 746
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Celegans
Match: deg-1 (Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:P24585])

HSP 1 Score: 55.8398 bits (133), Expect = 1.239e-7
Identity = 27/60 (45.00%), Postives = 42/60 (70.00%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKK 2246
            +QL  E+ +ES +Y + NL++D GG LGL+LGFSV++++E+  L V +I   F S  E+K
Sbjct:  687 EQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEEK 746
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Celegans
Match: unc-8 (Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:Q21974])

HSP 1 Score: 51.2174 bits (121), Expect = 3.229e-6
Identity = 22/48 (45.83%), Postives = 33/48 (68.75%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQL 2210
            +QL  E  +E+  Y + NL SD GG +GL++GFSV++  E AELF ++
Sbjct:  632 EQLNFESLKETAGYTLVNLFSDFGGNIGLWIGFSVITFAEFAELFCEI 679
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Celegans
Match: unc-8 (Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:Q21974])

HSP 1 Score: 51.2174 bits (121), Expect = 3.319e-6
Identity = 22/48 (45.83%), Postives = 33/48 (68.75%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQL 2210
            +QL  E  +E+  Y + NL SD GG +GL++GFSV++  E AELF ++
Sbjct:  673 EQLNFESLKETAGYTLVNLFSDFGGNIGLWIGFSVITFAEFAELFCEI 720
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Fly
Match: Nach (gene:FBgn0024319 transcript:FBtr0445749)

HSP 1 Score: 50.0618 bits (118), Expect = 7.413e-6
Identity = 34/108 (31.48%), Postives = 52/108 (48.15%), Query Frame = 3 
Query:  702 RLIKSFCKHTSGHG--FAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYG-----VNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEI 1004
            R    FC  +S HG  + +  ++ ++V L+W+LI V+ FI  VV   +    Y DY      +N     TP N+L  P +TICP+  F   +S    N+   P   E+
Sbjct:   25 RTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVV---MARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAEL 129
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Fly
Match: Nach (gene:FBgn0024319 transcript:FBtr0087116)

HSP 1 Score: 50.0618 bits (118), Expect = 7.914e-6
Identity = 34/108 (31.48%), Postives = 52/108 (48.15%), Query Frame = 3 
Query:  702 RLIKSFCKHTSGHG--FAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYG-----VNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEI 1004
            R    FC  +S HG  + +  ++ ++V L+W+LI V+ FI  VV   +    Y DY      +N     TP N+L  P +TICP+  F   +S    N+   P   E+
Sbjct:   25 RTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVV---MARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAEL 129
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Fly
Match: Nach (gene:FBgn0024319 transcript:FBtr0445750)

HSP 1 Score: 50.0618 bits (118), Expect = 8.734e-6
Identity = 34/108 (31.48%), Postives = 52/108 (48.15%), Query Frame = 3 
Query:  702 RLIKSFCKHTSGHG--FAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYG-----VNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEI 1004
            R    FC  +S HG  + +  ++ ++V L+W+LI V+ FI  VV   +    Y DY      +N     TP N+L  P +TICP+  F   +S    N+   P   E+
Sbjct:   25 RTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVV---MARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAEL 129
[Close]
BLAST of RRM domain-containing protein vs. UniProt/SwissProt
Match: sp|P24585|DEG1_CAEEL (Degenerin deg-1 OS=Caenorhabditis elegans OX=6239 GN=deg-1 PE=1 SV=2)

HSP 1 Score: 55.8398 bits (133), Expect = 1.577e-6
Identity = 27/60 (45.00%), Postives = 42/60 (70.00%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKK 2246
            +QL  E+ +ES +Y + NL++D GG LGL+LGFSV++++E+  L V +I   F S  E+K
Sbjct:  687 EQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEEK 746
[Close]
BLAST of RRM domain-containing protein vs. TrEMBL
Match: A0A1I8I9S9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 120.168 bits (300), Expect = 5.505e-24
Identity = 133/579 (22.97%), Postives = 249/579 (43.01%), Query Frame = 3 
Query:  624 EINKSENDHSFYSND--------PEKEDNDTESVRLIKSFCKHTSGHGFAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSL---TPDTTEIYKGTTFAELFSRYVDIWMPITGNISS--ITYARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSP--NEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKI-IRENSGSVCFDNPNDIVIKGYGLN-EMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASS---VIPDSASFCHEISS---------LLSTKLNNSFIMLNPKDNTDVI--------ANLKKNYLCHKTQISLLENEKFPETCLPACVESTYR---------YEVSSSKLERQLIGFKGVYNESINEIIPL-LQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIH 2219
            EI K     S  + D        P +ED +  S  ++  F   T+ HGF  IV+++  +R++W L++V+ F G  +H   L+ +Y  Y + +    + + +   PD+T+C   ++    +  + +  +   T  T        F    +     W    G      I Y+   +    Y I     + DI   I +K+  +++D + A    + F C T +P +R +NS++D  A  +I ++F     DQ+     +P  +     G  + +  PN  PN   +  +V    +K    +  +   R+     C+++ ND+ I+    +  +++Y Y+QS C E +  + + + C C S   +  +    +  S  +C ++           L ++  N S  +L  K ++ V+           +  + CH    +L +     ETC P+CV  TY+         +++     ER L  F+  YN S+ + +P+ L +  ++   I +   ++ +  F   V       L     +E  SYP+  L S++GGILGLY+G SV+S+ E  E    L +H
Sbjct:    3 EIKKENAAQSGITGDEPQDSDKKPSQEDGNG-SAGIVSEFFVTTTAHGFLHIVQNSIYLRIVWALLIVIAFGGFGLHLSTLVEKYLSYPLTTEIRYS-EVEFEFPDVTVCLTTKYRHCLNIDVRDPRIGLVTNSTVPSLGNYNFWSALNNTFTFWKQAYGLKDDLLIKYSTVGMRSYTYEINITNRRTDIATGIEYKQKALNLDNVVAYDDPELFRCATVRPKNRAINSVND--AMGLILSIF-----DQYIGNKTTPLIDRAWVAGVRVTLSEPNARPNLI-NSFIVPPGTIKHTKVSMTRQEKRKTPKQDCYESSNDLPIQVLNPDGTLSSYRYTQSDCRELELQKYVMRKCGCVSNFKLVPAEFKSLSGSLKYCLDLDPTILKAKKIFLANSSSNGSQTLLVEKFDSSVVPMELILAQTGFRAQHECHLK--ALGDFVASAETCPPSCVAYTYQAYSSESLWPFQIDQYFAERILNLFQSAYNYSLEKGLPVPLFKCFEAGATITSRDYWKMIGYFNRVV--ISSNSLRGTQYQEKESYPLAGLFSNMGGILGLYVGVSVISVCEFLEFLTLLTVH 567
[Close]
BLAST of RRM domain-containing protein vs. TrEMBL
Match: A0A267G3Q5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003120g3 PE=3 SV=1)

HSP 1 Score: 112.849 bits (281), Expect = 4.312e-22
Identity = 132/536 (24.63%), Postives = 220/536 (41.04%), Query Frame = 3 
Query:  687 DTESVRLIKSFCKHTSGHGFAKIVE-STRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNS--SFYTTPDNQLVMPDITICPNQRFYF--FESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWMPITGNISSIT----YARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVK--QFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASS----VIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENE------KFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTV-------EVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQL 2210
            ++ S +L+K FC+ TS HGF KI + S+ L R++W+LI++  F G   H I L  R+ +  VN+  S Y+T     V PDI+IC    F    +E +P   S   P            EL S     W P   + S I      +  S + +    K+ +               ++  + +  P +  F C TF P  R L    + D  + +  + YVG +  F ++  S       G    +H   T P    +G  V        Q  + +  ++R+ +       P + V + YG  ++  Y YS   C        + ++C C SEIL   +    +   + +FCH I        N   +  +    ++  +++++   CH   I+ +  +      K    C   C  + Y   V  +K        +    E+    +   +    S EV++     E L +  + + +F   +LTV        +  E+ +Y   NL SDIGGILGL+LG S++S  E  ELF+QL
Sbjct:   34 ESPSKKLLKQFCESTSAHGFHKIFQGSSILHRIVWLLIIITAFSGFSAHLISLFSRFNEGPVNTEISVYST---NFVFPDISICATSHFSLRRYERNPKIRSLNKP----------IKELVSDIRSFWDPNNESDSEINGDLLNSLKSYLHEVNITKQSQEMILHCDFAGTICSYINFTE-YIDPNY--FSCFTFSPRERHLLVGGERDGGLSV--IMYVGDMMNFISEEDSLR--YSKGFRAVIHEKGTRPEM-LEGFYVQEHACTYVQLGYTEEVVLRKCAEEESLQ-PLEFVDR-YG--KVTQYRYSVRDCQVNLYQNFLNESCRCVSEILPLPAKFRNITRHNITFCHHI--------NEERLKQSRGAKSNDSSSVREKQECHDNAINEIHKQVSAKKTKKDSYCPLKCNNTRYEMRVMQNKWPNDANETRQALWEATQRTMHEARSRGDSTEVLEEIM--EHLKNDPYALQRFA--KLTVYSHSTMGNIVRENWAYLARNLASDIGGILGLWLGVSIISTFEFFELFIQL 532
[Close]
BLAST of RRM domain-containing protein vs. TrEMBL
Match: A0A1I8IIE8 (RRM domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 114.005 bits (284), Expect = 6.855e-22
Identity = 138/540 (25.56%), Postives = 220/540 (40.74%), Query Frame = 3 
Query:  702 RLIKSFCKHTSGHGFAKIVESTR--LVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNS--SFYTTPDNQLVMPDITICPNQ---RFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWMP---ITGNIS---SITYARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYR--SLVKQFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASSVIPDSAS--FCHEIS--SLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENEK---FPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKS----VEVIKAAANYEFLTDFKFTVSKF-IPKQLTV-EVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSK 2237
            +LI+ FC  TS HGF KIVE+    L R  W+ I++    G   H   L  RY +  VN+  S Y T   + V PD+TIC      R  + ++ P+   SL   T E         L       W P      NIS    + ++  S +R+  +I + R +  +               L+  P +  F C TF P  R L    + D  + +  + YVG +  F    +S +     G    +H P T P    +G  V R  S   Q  + +  +++  S    F       +  Y  N +  Y Y+   C+       +   C+C SE L   + +  + S  FCH IS  SL+ +    +          +  A  ++   CH + +S +  +     P+ C   C    Y    + ++             E++   I L  ++       VE+ +  ++      F+ + +K  I    T+  V  ES +YP  NL SDIGGILGL+LG S++S  E  ELF +L+  +F  +K
Sbjct:   25 KLIRQFCDSTSAHGFHKIVENGEGALHRAAWLFIILAAGAGFTAHLFALFSRYLERPVNTETSVYGT---KFVFPDVTICATSHFSRLRYQQNPPV--PSLNISTHE---------LLHHIRTFWDPGENADTNISINADVMHSIKSYLRE-LNITKQRQEMILHCDFAGDSCSYRNFSLYVDPNY--FSCYTFAPTERHLIVGGERDGGLNV--IMYVGDVKNFITGEESLS--YSEGFRAVIHEPGTRPELL-EGFYVQRDTSTYVQLGYTEEVVLKNCSLDANFQTVK--FVDRY--NRITEYRYTIRDCLVNTYQTYLRTNCSCVSEALPLPANLNSNLSVPFCHSISRESLMESIDQQAATEAEAAIERNQAAEHRR--ACHDSVVSEIHKKTSGLAPDVCPLRCKNVRYEMRFTQNRWPSACNETSQALAEAVERTIALAAEQGDDLTTLVEIQRRMSDEHREPAFRESFAKLTIYTHSTMGSVMRESWAYPDRNLASDIGGILGLWLGVSIISTFEFLELFARLLFWHFPLTK 536
[Close]
BLAST of RRM domain-containing protein vs. TrEMBL
Match: A0A267EAK0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003120g1 PE=3 SV=1)

HSP 1 Score: 109.768 bits (273), Expect = 4.272e-21
Identity = 131/536 (24.44%), Postives = 219/536 (40.86%), Query Frame = 3 
Query:  687 DTESVRLIKSFCKHTSGHGFAKIVE-STRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNS--SFYTTPDNQLVMPDITICPNQRFYF--FESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWMPITGNISSIT----YARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVK--QFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASS----VIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENE------KFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTV-------EVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQL 2210
            ++ S +L+K FC+ TS HGF KI + S+ L R++W+LI++  F G   H I L  R+ +  VN+  S Y+T     V PDI+IC    F    +E +P   S   P            EL S     W P   + S I      +  S + +    K+ +               ++  + +  P +  F C TF P  R L    + D  + +  + YVG +  F ++  S       G    +    T P    +G  V        Q  + +  ++R+ +       P + V + YG  ++  Y YS   C        + ++C C SEIL   +    +   + +FCH I        N   +  +    ++  +++++   CH   I+ +  +      K    C   C  + Y   V  +K        +    E+    +   +    S EV++     E L +  + + +F   +LTV        +  E+ +Y   NL SDIGGILGL+LG S++S  E  ELF+QL
Sbjct:   34 ESPSKKLLKQFCESTSAHGFHKIFQGSSILHRIVWLLIIITAFSGFSAHLISLFSRFNEGPVNTEISVYST---NFVFPDISICATSHFSLRRYERNPKIRSLNKP----------IKELVSDIRSFWDPNNESDSEINGDLLNSLKSYLHEVNITKQSQEMILHCDFAGTICSYINFTE-YIDPNY--FSCFTFSPRERHLLVGGERDGGLSV--IMYVGDMMNFISEEDSLR--YSKGFRAVIQEKGTRPEM-LEGFYVQEHACTYVQLGYTEEVVLRKCAEEESLQ-PLEFVDR-YG--KVTQYRYSVRDCQVNLYQNFLNESCRCVSEILPLPAKFRNITRHNITFCHHI--------NEERLKQSRGAKSNDSSSVREKQECHDNAINEIHKQVSAKKTKKDSYCPLKCNNTRYEMRVMQNKWPNDANETRQALWEATQRTMHEARSRGDSTEVLEEIM--EHLKNDPYALQRFA--KLTVYSHSTMGNIVRENWAYLARNLASDIGGILGLWLGVSIISTFEFFELFIQL 532
[Close]
BLAST of RRM domain-containing protein vs. TrEMBL
Match: A0A1I8J7I0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 90.1225 bits (222), Expect = 1.115e-14
Identity = 118/555 (21.26%), Postives = 225/555 (40.54%), Query Frame = 3 
Query:  669 PEKEDNDTESVRLIKSFCKHTSGHGFAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSL---TPDTTEIYKGTTFAELFSRYVDIWMPITGNISS--ITYARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSP--NEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKI-IRENSGSVCFDNPNDIVIKGYGLN-EMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASS---VIPDSASFCHEISS---------LLSTKLNNSFIMLNPKDNTDVI--------ANLKKNYLCHKTQISLLENEKFPETCLPACVESTYR---------YEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIH 2219
            P +ED +  S  ++  F   T+ HGF  IV+++  +R++W L++V+ F G  +H   L+ +Y  Y + +    + + +   PD+T+C   ++    +  + +  +   T  T        F    +     W    G      I Y+   +    Y I     + DI   I +K+  +++D + A    + F C T +P  R +NS+  +DA  +I ++F     DQ+     +P  +     G  + +  PN  PN   +  +V    +K    +  +   R+     C+++ ND+ I+    +  +++Y Y+QS C E +  + + + C C S   +  +    +  S  +C ++           L ++  N S  +L  K ++ V+           +  + CH    +L +     ETC P+CV  TY+         +++     ER L  F+  YN S+ + +P+        +  +A A      D+   +  F P                           GLY+G SV+S+ E  E    L +H
Sbjct:   26 PSQEDGNG-SAGIVSEFFVTTTAHGFLHIVQNSIYLRIVWALLIVIAFGGFGLHLSTLVEKYLSYPLTTEIRYS-EVEFEFPDVTVCLTTKYRHCLNIDVRDPRIGLVTNSTVPSLGNYHFWSALNNTFTFWKQAYGLKDDLLIKYSTVGMRGYTYEINITNRRTDIATGIEYKQKALNLDNVVAYDDPELFRCATVRPKDRAINSV--NDAMGLILSIF-----DQYIGNKTTPLIDRAWVAGVRVTLSEPNARPNLI-NSFIVPPGTIKHTKVSMTRQEKRKTPKQDCYESSNDLPIQVLNPDGTLSSYRYTQSDCRELELQKYVMRKCGCVSNFKLVPAEFKSLSGSLKYCLDLDPTILKAKKIFLANSSSNGSQTLLVEKFDSSVVPMELILAQTGFRAQHECHLK--ALGDFVASAETCPPSCVAYTYQAYSSESLWPFQIDQYFAERILNLFQSAYNYSLEKGLPV-----PLFKCFEAGATIT-SKDYWKMIGYFQPG--------------------------GLYVGVSVISVCEFLEFLTLLTVH 536
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Nematostella
Match: EDO36191 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJB5])

HSP 1 Score: 52.7582 bits (125), Expect = 4.619e-7
Identity = 26/59 (44.07%), Postives = 36/59 (61.02%), Query Frame = 3 
Query: 2043 FTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIH 2219
            F   K   ++L  E    SLSYP+ENLL D+GG LGL++G SV++  E  +L V L  +
Sbjct:  399 FLRVKLYYEELNRETITYSLSYPVENLLGDVGGQLGLWIGVSVITCAEFLKLLVDLAWY 457
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Nematostella
Match: EDO37667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF92])

HSP 1 Score: 51.6026 bits (122), Expect = 9.759e-7
Identity = 36/125 (28.80%), Postives = 64/125 (51.20%), Query Frame = 3 
Query: 1845 ETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIH 2219
            E C P C E  ++  +SS++       ++  +   ++E+     +E+K   V+ A A+        F   +   ++L  EV EE  SY + N +SDIGG LGL++G S ++  E+ EL + + +H
Sbjct:  118 EKCRPPCNEEVFKLSISSARWPTD--DYEAHF---LDEL-----KEDKGF-VLPANADARAY----FVKLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALH 227
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Nematostella
Match: EDO49452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGQ6])

HSP 1 Score: 50.8322 bits (120), Expect = 1.492e-6
Identity = 21/60 (35.00%), Postives = 40/60 (66.67%), Query Frame = 3 
Query: 2067 KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKK 2246
            +++ V + ++  +Y  E+L  DIGG +GL+LG S++++LE  +L  +++IH F   K +K
Sbjct:  384 EEMQVTLIQQRQAYDQESLFGDIGGQVGLFLGASILTVLEFLDLLWRILIHKFKKRKNRK 443
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Nematostella
Match: EDO31696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX71])

HSP 1 Score: 50.8322 bits (120), Expect = 1.538e-6
Identity = 47/154 (30.52%), Postives = 65/154 (42.21%), Query Frame = 3 
Query: 1806 KTQISLLENEKFPET-CLPACVESTYRYEVS-----SSKLERQLIG--FKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEK 2243
            K +  L  NE    T C PAC E  YR   S     S + +  +I   F G++N S +      +     V +     NY            FI         EES++Y + N LSDIGG LGL++G SVM+  E+ EL + +    F     K
Sbjct:  276 KVKFKLSRNELGCSTACGPACREEAYRLTSSFAVWPSQRYQNSIIDNLFDGIFNYSRS----WFRDNYLEVNIFFKELNY------------FI---------EESVAYELVNFLSDIGGQLGLWVGVSVMTGAEVVELALLIFFKVFCRKPRK 404
[Close]
BLAST of RRM domain-containing protein vs. Ensembl Nematostella
Match: EDO37452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFR0])

HSP 1 Score: 51.2174 bits (121), Expect = 1.654e-6
Identity = 37/136 (27.21%), Postives = 64/136 (47.06%), Query Frame = 3 
Query: 1818 SLLENEKF--PETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIH 2219
            SL ++ K    E C P C E  ++  +SS++            ++     +  L+++   V    A A   F+        +   ++L  EV EE  SY + N +SDIGG LGL++G S ++  E+ EL + + +H
Sbjct: 1000 SLYQDNKLGCSEKCRPPCNEEVFKLSISSARWPT---------DDYEAHFLDELKEDKGFVLPANADARAYFVK------LQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALH 1120
[Close]
BLAST of RRM domain-containing protein vs. Planmine SMEST
Match: SMESG000019202.1 (SMESG000019202.1)

HSP 1 Score: 1093.18 bits (2826), Expect = 0.000e+0
Identity = 546/552 (98.91%), Postives = 549/552 (99.46%), Query Frame = 3 
Query:  594 MKSSFDNKSFEINKSENDHSFYSNDPEKEDNDTESVRLIKSFCKHTSGHGFAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWMPITGNISSITYARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASSVIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKKG 2249
            MKSSFDNKSFEINKSENDHSFYSNDPEKEDNDTESVRLIKSFCKHTSGHGFAKIVESTRLVRLIWILIM+LTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIW PITGNISSITYARYSIMRQAYSIKRLRGKNDIIIKINFKKIQ+SVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKIIRENSGSVCFD PNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSE+LIASSVIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYE LTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKKG
Sbjct:    1 MKSSFDNKSFEINKSENDHSFYSNDPEKEDNDTESVRLIKSFCKHTSGHGFAKIVESTRLVRLIWILIMMLTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWTPITGNISSITYARYSIMRQAYSIKRLRGKNDIIIKINFKKIQISVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKIIRENSGSVCFDKPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSELLIASSVIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYELLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEKKG 552
[Close]
BLAST of RRM domain-containing protein vs. Planmine SMEST
Match: SMESG000013072.1 (SMESG000013072.1)

HSP 1 Score: 211.846 bits (538), Expect = 3.348e-59
Identity = 140/513 (27.29%), Postives = 261/513 (50.88%), Query Frame = 3 
Query:  702 RLIKSFCKHTSGHGFAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITICPNQRFYFFESSPLFN---SSLTPDTTEIYKGTTFAELFSRYVDIWMPITGNISSITYARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITD--PGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASSVIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDV-------IANLKKNYLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFV 2204
            ++ ++FC  T+ HGF K++E T+++R+IWI IM +T  GL+   ++L+ R     +N+       ++  MPD+TICP QRF+F++   L N    + TP    +    +F + F +   IW  +     +    RYSI++ + ++  LRG NDI++K N+    VS ++       D F C+ F+P  R + +L++     +I  +  +G  D +E+  +S +E+     GS++++H P T+P F++   +V R  + Q +  + +       + C +N + + I+     +++ + Y+QS C+  +K   IY+ CNC SEIL     IP++   CH+IS  L   ++NSF     KDN            +L+ N+ CH   +    ++     C   C   T+ Y+VS   ++  +  F+ +  E+ +E+I            ++   N EF    K      +PK   + + +E+L Y +    SD+GG +GL++GF+++++ ++ EL +
Sbjct:   34 QIWETFCLKTNAHGFFKVIEDTKIMRIIWICIMCVTVSGLLALIVVLLERLLASNLNAEVEIKSKHEFSMPDVTICPKQRFFFYDEKLLTNYIIPAFTPSDIAVLNNISFYQYFIQSSLIWNILGFEADANKLGRYSILQISQNLNLLRGPNDILVKTNYLTRNVSSNEFHFLMRPDGFRCLIFRPNDRNIKTLNEIPDLFLIILIPMIGNDDIYESIFQSSSEVEQMRSGSSIFIHPPMTLPEFETQELIVPRDNLLQLAIERNEYYLYEINNKCQNNNSPLRIRQS--EKISEFLYTQSGCLNLRKQLYIYRNCNCVSEILFLPEEIPETVIPCHQISVEL---ISNSF-----KDNYTAWLVQQPSARSLQLNHQCHDKFLLSFNSDNEINNCPVPCDSVTFTYDVSLLNIKDIVPQFQPLIFEAASEVIAKFANSTVPTGQVENLYNIEF--SMKLGFMSLLPKSFKITIMKETLVYQLGQFFSDVGGSMGLFVGFTIITLFDLMELLI 534
[Close]
BLAST of RRM domain-containing protein vs. Planmine SMEST
Match: SMESG000079502.1 (SMESG000079502.1)

HSP 1 Score: 105.531 bits (262), Expect = 2.019e-23
Identity = 128/556 (23.02%), Postives = 227/556 (40.83%), Query Frame = 3 
Query:  663 NDPEKEDNDTESVR-LIKSFCKHTSGHGFAKIVESTRLV-RLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFY--TTPDNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWMPITGNISSITYARYSIMRQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQ----MKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEILIASSVIP----DSASFCHEIS-SLLSTKLNNSFIMLNP----KDNTDVIANLKKNYLCHKTQISLLENEKFPETCLPACVESTY------------------RYEVSSSKLERQLIGFKGVYNESINEI-IPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIP-KQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIH 2219
            +D   ++N T SV+     +   T+ HGF +IV +  +  ++IW+  M++   GL  HF+ L++ + ++ V +      TP      P + ICP   +       LFN+        I    TF ++F  + + W  +       T +R S    AY +++L    D  +   +   Q      F      +  C+    P+  +    +S       N+F+    D   +     + + + I +  S +   S +  P+F ++     R  +     +         G  CF NP++  I  +  ++   + Y+QSLC+  KK   +   C C SE L   S       +   FCH++S   ++  + N+ + L      K++  +I N K    CH   +S+ +++    TC P C   +Y                   Y      +   L+     YN S++E  +  LQQ              E L  +K    K +P +Q  +++ E+  SYP+ N LS  G ILGL++G SV+S+ EI + F+  I H
Sbjct:   20 SDINFQNNRTSSVKEYFYEWASTTTTHGFLQIVTTKTITGKIIWLTFMIVAISGLSYHFVTLLIGHLNHEVQTEMSKDVTPYE---TPSLVICPEIPYV-----NLFNTE-----KAIISNLTFLDIFQLFNNFWSTVNQTTEIKTKSRLSFAPYAYELQQLVLAEDFQLICKYNAEQKCNSFTFMVQDLSN--CIKIDIPTSTVTQPFNS------LNIFFAYNFDSSRDSSVAFLDNKDIIAERKSFITFQSKDEYPDFNTNRIFGIRQQMAAIYLDIRVQQLFQVGDSCFVNPSNYEILSFD-SKKTQFAYTQSLCMMLKKQASVKDNCGCYSETLPIESTTQYSKIEQIPFCHKMSRGFINFLIGNANLTLYSLTLEKESIKLIQNSK----CHDNYLSIWQDDG---TCKPKCTTKSYSTGYVLYNQWPLSFLTSQEYSDIQGAINMTLMKKAAKYNLSLSEFRLSALQQ-------------LEELVIYKMGAFKVMPSRQYGLQIIEKE-SYPLANFLSSFGAILGLWIGMSVISIFEILQ-FIYTICH 531
[Close]
BLAST of RRM domain-containing protein vs. Planmine SMEST
Match: SMESG000079503.1 (SMESG000079503.1)

HSP 1 Score: 95.1301 bits (235), Expect = 4.929e-20
Identity = 119/526 (22.62%), Postives = 216/526 (41.06%), Query Frame = 3 
Query:  717 FCKHTSGHGFAKIVESTRLV-RLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFYTTPDNQLVMPDITIC---PNQRFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRYVDIWMPITGNISSITYARYSIM--RQAYSIKRLRGXXXXXXXXXXXXXQVSVDKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFENQMKSPNEITDPGSTLYM--------HSPNTMPNFKSDGHMVYRSLVKQFSFN---QAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEIL----IASSVIPDSASFCHEISSLLSTKLN---NSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNE-SINEIIPLLQQENKSVEVIKAAANY-------EFLTDFKFTVSKFIPKQLTVEVTEESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAEL 2198
            F   T  HGF ++  +  L  R++WI+IM LTF GL+ HFI +++ +  + V +           MP + IC   P  + +  +   +FN              T +  F  +   W  +    +    +R+SI    Q Y +  L  ++  +       ++ +V         D  VC     P      L  +  ++   N++Y      F +    PN        +Y+         +    PNF S     ++  +   + N   Q + + +NS   C  NP  + I  YG N +  ++Y++SLC+  KK   I++ C C SE L     + ++  D   FCH++S      L    N   +LN K+     A L  + +CH      L +     +C+  C   +Y +  + + +    + F    N+  I++I   + Q+     V +    Y       + +++ K    K +P+  +     ES +YP+ N LS IG IL L++G S+++++E  E+
Sbjct:   41 FASTTKAHGFLQVATTEALSGRILWIIIMALTFGGLIFHFITMLMIFLAHEVQTEMVNNAV-PFEMPTVIICPDAPYAKLFKVDRPVIFN-------------MTLSGAFDTFNAFWKLVNKTTNIQEKSRFSIAPYAQEYQLFTL-SEDLTVFCKYNNAVKCNVSNFMIE---DLSVCAKIDIP------LDTTKTSLSQLNVWY----SFFTDASYLPNTTFYNSKYMYILRTAYLTYQAKEEYPNFHSTRISGFKQFMTTINLNIRIQNEFLVKNS---CLSNPEPMKILSYG-NAILQFSYTKSLCLMVKKQNYIFQNCKCFSEALPIPNYSDNITIDIVPFCHKLSKGFIEYLKTIPNPINILNNKET----AQLTSSSVCHD---HFLNSWIDDGSCISPCTSKSYSWS-NINAVSWPTVTFTNTPNKILISDIQSNINQKMAKYNVTENDLVYSTIKTTSDIISNRKLGSFKIVPQTPSGLKITESENYPLTNFLSTIGSILVLWVGISIINIIEFFEM 526
[Close]
BLAST of RRM domain-containing protein vs. Planmine SMEST
Match: SMESG000053471.1 (SMESG000053471.1)

HSP 1 Score: 74.7146 bits (182), Expect = 1.298e-13
Identity = 76/300 (25.33%), Postives = 131/300 (43.67%), Query Frame = 3 
Query: 1383 TLYMHSPNTMPN---FKSDGHMVYRSLVKQFSFNQAKIIRENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCRSEIL-----IASSVIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKNYLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYNESINEIIPLLQQEN---KSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTEESLSYPIEN------LLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFIS 2231
             +Y+H   T PN    ++  +  + ++  + S+N+          VC D   DI +     +E+ T+TYS+SLC +     +I+ TCNC SE L         V  +  ++CH I   L    N++           +I  +K    CH     L+ N  +      +C +    Y+VS      QL     V    +N    L    N   K  +   + + ++ L D           Q+ ++ + E L +   N       LS+IGGI+GLY+G+S ++++EI   FV+LI+++FI+
Sbjct:  220 AVYLHPLGTYPNGLALEAVKNQYFLNINYELSYNRL---------VCNDVFEDIKVLSRLNDEILTFTYSKSLCDQISTQRIIFATCNCISETLPIPNDFYGIVYNNVDNYCHAIWGGLLDASNSTV--------ESIIERVK----CHD---KLINNMSY------SCPQKCNYYDVSVFSQYSQLKTTTEVLKNFVNLYNYLKSTNNTNKKQRQFFDSQSYFKLLNDLNINSPTEAFLQIGIDYSPEVLMFESRNAFDKMAFLSEIGGIMGLYMGWSAITVIEIIVFFVELIVYHFIA 489
The following BLAST results are available for this feature:
BLAST of RRM domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
deg-11.239e-745.00Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
deg-11.239e-745.00Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
deg-11.239e-745.00Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
unc-83.229e-645.83Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
unc-83.319e-645.83Degenerin unc-8 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
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BLAST of RRM domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Nach7.413e-631.48gene:FBgn0024319 transcript:FBtr0445749[more]
Nach7.914e-631.48gene:FBgn0024319 transcript:FBtr0087116[more]
Nach8.734e-631.48gene:FBgn0024319 transcript:FBtr0445750[more]
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BLAST of RRM domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 1
Match NameE-valueIdentityDescription
sp|P24585|DEG1_CAEEL1.577e-645.00Degenerin deg-1 OS=Caenorhabditis elegans OX=6239 ... [more]
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BLAST of RRM domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8I9S95.505e-2422.97Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267G3Q54.312e-2224.63Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8IIE86.855e-2225.56RRM domain-containing protein OS=Macrostomum ligna... [more]
A0A267EAK04.272e-2124.44Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8J7I01.115e-1421.26Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of RRM domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO361914.619e-744.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO376679.759e-728.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO494521.492e-635.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316961.538e-630.52Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374521.654e-627.21Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of RRM domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RRM domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000019202.10.000e+098.91SMESG000019202.1[more]
SMESG000013072.13.348e-5927.29SMESG000013072.1[more]
SMESG000079502.12.019e-2323.02SMESG000079502.1[more]
SMESG000079503.14.929e-2022.62SMESG000079503.1[more]
SMESG000053471.11.298e-1325.33SMESG000053471.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033721 ID=SMED30033721|Name=RRM domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2486bp
AATTTGAATAACTTGATAATTATTAGTAACTAATATGGAAATGTATCTTC
TTTCTTATATTTGTATTTTATTTTATGCAAATTTATAGCATCCATCCAAT
ATATAATAAAATATACTGTTATATGTAAAACTTATTAAAATTCTTTAGTC
ATTATTATAAATTATATTTTTAAAAATCATAATTTTTTGAACATGGCGTT
AAAGTGAATTGAAAACCCTATTACGTTGAATACCTGCAGACTTTACAATG
TGAACAAAAACTTACTATTATTCTAAAATGTTTAACAATAGATACATTGA
TGCGCAAATGGAGTTTTAAAAATTAAAAGAATACAAAAAAATGTTGAAGT
ATCATTTTATAATATATTCATTTATTTTCAGAATATAGATTAATCTTTTG
TTTTAAATTTATATTTAACAAAAGATTAATCCATAGTTTGTTATGAAATA
AAAGTAAAGAATGTTAATAAAGAGAATCGATCAAAAATGAAAAAGATAAA
AGTTTTGTTTTACTTAAATCGGTATAGATTGGTAAATATTAACAATAGCT
TTGAAATTGGCATTTATTTTGAGATTTTATTTTTGATTTAGAAATGAAAT
CATCATTCGATAACAAATCTTTTGAAATTAACAAATCTGAAAATGATCAC
AGTTTCTATTCAAATGATCCTGAAAAAGAAGATAACGACACTGAATCAGT
GAGGTTGATTAAATCCTTTTGTAAGCATACAAGTGGGCATGGATTTGCAA
AAATTGTCGAAAGTACTAGATTGGTTCGTTTGATTTGGATATTGATAATG
GTGTTGACATTTATTGGGCTGGTAGTTCATTTTATCCTATTAATTCTAAG
ATACTTTGATTATGGGGTAAATTCATCTTTTTATACGACCCCTGACAATC
AGTTAGTAATGCCAGATATAACAATTTGCCCAAATCAGCGCTTTTATTTT
TTTGAAAGCAGTCCTCTATTCAACTCATCTCTAACTCCAGATACTACAGA
GATATATAAAGGTACAACCTTTGCAGAATTGTTTTCTCGCTATGTTGACA
TTTGGATGCCTATTACTGGAAACATCTCTTCCATAACTTATGCAAGATAT
TCAATAATGAGACAAGCTTATTCTATCAAAAGATTGAGAGGAAAAAATGA
CATAATAATAAAAATAAATTTTAAGAAAATTCAAGTATCCGTAGATAAGC
TGTTTGCCACTCCAACATTTGATAGTTTTGTCTGTGTGACTTTCAAACCT
CCAAGTCGAGTGTTAAATTCTCTTAGTGACTCAGATGCAACTGTGATAAT
TACTAATATGTTTTATGTTGGAGCACTGGACCAATTTGAAAACCAAATGA
AGTCGCCTAATGAAATAACCGATCCAGGTTCGACTTTATACATGCACTCT
CCTAATACCATGCCAAACTTTAAGAGTGATGGTCACATGGTTTATAGAAG
TCTTGTAAAGCAATTTTCTTTTAATCAAGCTAAAATAATAAGAGAAAATA
GTGGCAGTGTTTGTTTTGATAACCCTAATGATATTGTCATAAAAGGATAC
GGTTTGAATGAAATGAATACCTACACTTATTCCCAATCTCTGTGCGTGGA
AACAAAAAAAAGTGAAATGATTTATAAAACATGCAATTGTCGTTCAGAAA
TTTTGATTGCTTCATCTGTTATTCCAGATTCCGCGTCTTTCTGTCATGAG
ATTTCCTCTCTGCTATCGACAAAATTAAATAATTCATTTATAATGTTAAA
TCCAAAGGACAACACAGACGTTATTGCAAATTTGAAAAAAAACTATTTGT
GTCATAAAACGCAAATTAGTCTATTAGAAAATGAAAAATTCCCCGAAACA
TGTTTACCAGCATGTGTTGAAAGTACCTATCGGTATGAAGTTTCATCCTC
AAAATTAGAGCGACAGTTAATTGGGTTTAAAGGGGTTTATAATGAATCTA
TCAATGAAATAATACCTCTTCTTCAACAAGAGAACAAATCAGTTGAAGTC
ATTAAAGCGGCCGCAAATTATGAATTTCTCACGGACTTCAAGTTTACGGT
TTCAAAGTTCATTCCGAAACAACTAACAGTTGAAGTTACCGAAGAAAGTT
TGTCATATCCGATTGAAAATTTATTGTCTGATATTGGAGGAATTTTGGGA
TTATATTTAGGATTTTCGGTGATGTCAATGCTGGAGATTGCAGAATTGTT
TGTACAACTGATTATACACAATTTCATTAGTTCCAAAGAAAAGAAAGGCT
AAATATTTCAAAATATTGCACATAAAAATTAGGATAATATGTTGTTTAAT
CAAGTAAAATAAACATCATTTTCTGCTAAATTATTTAAAATTTTTTTGAT
ACAATTTGATTATTGGTTAACTTGCGTAGAAAGTTTTATTATCATTTAGT
TATTGTTGATGTGATTTCTAGTCCGAAGGAGACTGATAAACGGTCGAGAT
GTATAGCGAGATGTTATACAATATATTCACTTAGAG
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protein sequence of SMED30033721-orf-1

>SMED30033721-orf-1 ID=SMED30033721-orf-1|Name=SMED30033721-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=553bp
MKSSFDNKSFEINKSENDHSFYSNDPEKEDNDTESVRLIKSFCKHTSGHG
FAKIVESTRLVRLIWILIMVLTFIGLVVHFILLILRYFDYGVNSSFYTTP
DNQLVMPDITICPNQRFYFFESSPLFNSSLTPDTTEIYKGTTFAELFSRY
VDIWMPITGNISSITYARYSIMRQAYSIKRLRGKNDIIIKINFKKIQVSV
DKLFATPTFDSFVCVTFKPPSRVLNSLSDSDATVIITNMFYVGALDQFEN
QMKSPNEITDPGSTLYMHSPNTMPNFKSDGHMVYRSLVKQFSFNQAKIIR
ENSGSVCFDNPNDIVIKGYGLNEMNTYTYSQSLCVETKKSEMIYKTCNCR
SEILIASSVIPDSASFCHEISSLLSTKLNNSFIMLNPKDNTDVIANLKKN
YLCHKTQISLLENEKFPETCLPACVESTYRYEVSSSKLERQLIGFKGVYN
ESINEIIPLLQQENKSVEVIKAAANYEFLTDFKFTVSKFIPKQLTVEVTE
ESLSYPIENLLSDIGGILGLYLGFSVMSMLEIAELFVQLIIHNFISSKEK
KG*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0003723RNA binding
GO:0005272sodium channel activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 394..414
NoneNo IPR availableGENE3DG3DSA:1.10.287.820coord: 300..424
e-value: 2.6E-32
score: 114.3
NoneNo IPR availableGENE3DG3DSA:1.10.3590.10coord: 115..262
e-value: 2.6E-32
score: 114.3
NoneNo IPR availableGENE3DG3DSA:2.60.470.10coord: 92..503
e-value: 2.6E-32
score: 114.3
NoneNo IPR availableGENE3DG3DSA:1.10.287.770coord: 62..533
e-value: 2.6E-32
score: 114.3
NoneNo IPR availableTMHMMTMhelixcoord: 63..85
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 501..515
score: 46.4
coord: 102..118
score: 25.65
coord: 515..531
score: 48.24
coord: 62..79
score: 18.22
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 42..535
e-value: 4.8E-53
score: 180.7
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 37..545