slc46a-4

Overview


Name	slc46a-4 (AKN21696.1)
Smed ID	SMED30033628
Length (bp)	1791

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of slc46a-4 (SMED30033628) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for slc46a-4 (SMED30033628) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033628

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
parenchymal cell	SMED30033628	SMESG000065066.1	dd_Smed_v4_15244_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of slc46a-4 vs. Ensembl Human
Match: SLC46A1 (solute carrier family 46 member 1 [Source:HGNC Symbol;Acc:HGNC:30521])

HSP 1 Score: 56.6102 bits (135), Expect = 9.252e-8
Identity = 101/463 (21.81%), Postives = 192/463 (41.47%), Query Frame = 1

Query:  373 CRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRI--------VCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEE-------------KLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKY-LNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIG-ISTLNHHLKLK 1692
            CR    VE L+FL     + +  +  Q+++H+    L +      G   N S     ++     V+ L+ ++ + +++G  +  LF+S      +   GRR L++ + +G  ++++    ++     +  F+    L  L G    L +  F+ +A+ S   +R  R+        V G++AS LG        G+ ++  G+  PF +A  + +    Y  FC  ++  E +              +L + P   +  + +  A   L+ F V+ + FG        A +IL    +S P+C +S  IGY  + + L       L    L +Y L +  V  I L+F +L  +   +A     ++  +G   LS    P I+  LSKL     Q  LF  +  +       +  +   LY  TL   +   +L+     G+  + ++LIG +   + HL+ +
Sbjct:   21 CRGP--VEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQE-----VETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLG--------GHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHL--ALYSLAIFVVITVHFG--------AQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLT--SLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLL---GAGLLLIPAVLIGMLEKADPHLEFQ 453

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BLAST of slc46a-4 vs. Ensembl Human
Match: SLC46A1 (solute carrier family 46 member 1 [Source:HGNC Symbol;Acc:HGNC:30521])

HSP 1 Score: 50.0618 bits (118), Expect = 9.408e-6
Identity = 68/318 (21.38%), Postives = 134/318 (42.14%), Query Frame = 1

Query:  373 CRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRI--------VCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEE-------------KLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEIL 1263
            CR    VE L+FL     + +  +  Q+++H+    L +      G   N S     ++     V+ L+ ++ + +++G  +  LF+S      +   GRR L++ + +G  ++++    ++     +  F+    L  L G    L +  F+ +A+ S   +R  R+        V G++AS LG        G+ ++  G+  PF +A  + +    Y  FC  ++  E +              +L + P   +  + +  A   L+ F V+ + FG        A +IL    +S P+C +S  IGY  + + L
Sbjct:   21 CRGP--VEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQE-----VETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLG--------GHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHL--ALYSLAIFVVITVHFG--------AQDILTLYELSTPLCWDSKLIGYGSAAQHL 313

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BLAST of slc46a-4 vs. Ensembl Zebrafish
Match: SLC46A3 (si:dkey-5g14.1 [Source:ZFIN;Acc:ZDB-GENE-091204-361])

HSP 1 Score: 62.7734 bits (151), Expect = 5.723e-10
Identity = 85/390 (21.79%), Postives = 174/390 (44.62%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLAN-ASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKP-EIEEKLDLKPTILEFSEII---FSAKNILSSFTVVLLMFGFFYVG--ETAASEILYYIFMSYPICMNSIQIGY--SISLEILVLNIGLILSGTILNKYLNELVVILICLSF-GLL-FNIQMI---YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLF 1503
            ++++ +E ++ +Y         +++Q++Y ++ L +      VS N    + +++    + ++VQ  +  + M   L   I  L  +   +  + + GR+I II   IG  I ++    + F   +L   I    +  L GG   +   CFS +A+     + + LR+    +   + A + S+STGY +   GF  PF  + I  V  + Y IF LE+++  +  E L     +   +  I   F+  +   ++ +VLL+  F  +    T    I     ++ P+C   I +GY  + S  I +         + +  +L  L +  I ++F G+L   + M+   +AKT  ++++     + +   FP ++  +SK+ + + Q  LF
Sbjct:    2 KRLYFIEPVVAIYAFASFMLYPLIQQYVYRRLWLEITNSTYPVSENTSQCAANSSNHTSRQEEVQKAASLFSMYTDLSSMIPSLIVTLLLVSYSDQRGRKITIIMPLIGTLIYTLSFLTVSFFQLNLYLLIVASFVSALFGGIGTMLGGCFSYVADLCEDGKQKTLRMAVVDMMIGMLAGVASISTGYFLHAAGFNWPFFTSAIFQVVNLLYAIFILEETRVIDRSETLACCQALRNLACSIYSLFAGGSRRRTWVLVLLIITFSSLSFVNTGGLSIFTLYELNEPLCWTEILVGYGSAASTSIFIT--------SFVGVFLFSLCLPNIAIAFIGMLSVAVSMLMTGFAKTTLTMFLVRIPAMFAIMPFPVLRSMMSKVVSKSEQGALF 383

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BLAST of slc46a-4 vs. Ensembl Zebrafish
Match: SLC46A3 (si:dkey-5g14.1 [Source:ZFIN;Acc:ZDB-GENE-091204-361])

HSP 1 Score: 62.3882 bits (150), Expect = 6.920e-10
Identity = 85/390 (21.79%), Postives = 174/390 (44.62%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLAN-ASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKP-EIEEKLDLKPTILEFSEII---FSAKNILSSFTVVLLMFGFFYVG--ETAASEILYYIFMSYPICMNSIQIGY--SISLEILVLNIGLILSGTILNKYLNELVVILICLSF-GLL-FNIQMI---YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLF 1503
            ++++ +E ++ +Y         +++Q++Y ++ L +      VS N    + +++    + ++VQ  +  + M   L   I  L  +   +  + + GR+I II   IG  I ++    + F   +L   I    +  L GG   +   CFS +A+     + + LR+    +   + A + S+STGY +   GF  PF  + I  V  + Y IF LE+++  +  E L     +   +  I   F+  +   ++ +VLL+  F  +    T    I     ++ P+C   I +GY  + S  I +         + +  +L  L +  I ++F G+L   + M+   +AKT  ++++     + +   FP ++  +SK+ + + Q  LF
Sbjct:    2 KRLYFIEPVVAIYAFASFMLYPLIQQYVYRRLWLEITNSTYPVSENTSQCAANSSNHTSRQEEVQKAASLFSMYTDLSSMIPSLIVTLLLVSYSDQRGRKITIIMPLIGTLIYTLSFLTVSFFQLNLYLLIVASFVSALFGGIGTMLGGCFSYVADLCEDGKQKTLRMAVVDMMIGMLAGVASISTGYFLHAAGFNWPFFTSAIFQVVNLLYAIFILEETRVIDRSETLACCQALRNLACSIYSLFAGGSRRRTWVLVLLIITFSSLSFVNTGGLSIFTLYELNEPLCWTEILVGYGSAASTSIFIT--------SFVGVFLFSLCLPNIAIAFIGMLSVAVSMLMTGFAKTTLTMFLVRIPAMFAIMPFPVLRSMMSKVVSKSEQGALF 383

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Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLAN-ASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKP-EIEEKLDLKPTILEFSEII---FSAKNILSSFTVVLLMFGFFYVG--ETAASEILYYIFMSYPICMNSIQIGY--SISLEILVLNIGLILSGTILNKYLNELVVILICLSF-GLL-FNIQMI---YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLF 1503
            ++++ +E ++ +Y         +++Q++Y ++ L +      VS N    + +++    + ++VQ  +  + M   L   I  L  +   +  + + GR+I II   IG  I ++    + F   +L   I    +  L GG   +   CFS +A+     + + LR+    +   + A + S+STGY +   GF  PF  + I  V  + Y IF LE+++  +  E L     +   +  I   F+  +   ++ +VLL+  F  +    T    I     ++ P+C   I +GY  + S  I +         + +  +L  L +  I ++F G+L   + M+   +AKT  ++++     + +   FP ++  +SK+ + + Q  LF
Sbjct:    2 KRLYFIEPVVAIYAFASFMLYPLIQQYVYRRLWLEITNSTYPVSENTSQCAANSSNHTSRQEEVQKAASLFSMYTDLSSMIPSLIVTLLLVSYSDQRGRKITIIMPLIGTLIYTLSFLTVSFFQLNLYLLIVASFVSALFGGIGTMLGGCFSYVADLCEDGKQKTLRMAVVDMMIGMLAGVASISTGYFLHAAGFNWPFFTSAIFQVVNLLYAIFILEETRVIDRSETLACCQALRNLACSIYSLFAGGSRRRTWVLVLLIITFSSLSFVNTGGLSIFTLYELNEPLCWTEILVGYGSAASTSIFIT--------SFVGVFLFSLCLPNIAIAFIGMLSVAVSMLMTGFAKTTLTMFLVRIPAMFAIMPFPVLRSMMSKVVSKSEQGALF 383

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BLAST of slc46a-4 vs. Ensembl Zebrafish
Match: slc46a3 (solute carrier family 46 member 3 [Source:ZFIN;Acc:ZDB-GENE-100105-2])

HSP 1 Score: 56.225 bits (134), Expect = 7.341e-8
Identity = 88/428 (20.56%), Postives = 186/428 (43.46%), Query Frame = 1

Query:  442 VMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLAN--------ASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEK-----------SKPEIEEKLDLKP-----TILEFSEIIFSAKNILSSFTVVLLM--FGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLS 1647
            +++Q++Y ++   L  F    +  + ++  SN +       VQ  +  +++   L F I  L ++   +  +   GR++ I+   +G  + ++   L+   ++SL+  +    + GL GG   L   CF+ +A+           V    L ++ GV+       + S+ TG+ IK  GF  PF+ A  + +  + Y +  L++           S P   E   L+      T L+   ++F+A N   +  ++L++  F FF +       I     ++ P+C + + +GY  +L   +  +       +L++ L +  +IL+ L       I   +AKT   +++     +LS    P ++  +SK+ + + Q  +F  +  +E+    +S +V   +Y  T           L+ F+G +F+L+
Sbjct:   24 LLQQYVYRRLWFELSGFI--YTSESLSHCSSNHSYITLHQAVQKETSLFLLHSELCFLIPSLISALLLVSYSDYCGRKVAIVPPLVGEALHALSYVLVSRFSFSLNYLLASSFMSGLMGGPPTLIGGCFAYVADLCGEDLEGQKTVRMARLDMILGVLT-----GLASLCTGFFIKAAGFTWPFLTAVFLHLINLLYVLVVLKESLVLPNSAVSTSSPSASEAPRLRQTQALTTRLQGVYLLFAASNRRRNVVLLLMLAAFAFFKLALQGGWSIFILYELNTPLCWSEVFVGYGSALSTAIYLVSFA-GVALLSRCLPDAYIILLGLMSVAAGLIMAAFAKTTLLMFLVRLPLLLSIMPTPVLRSMMSKIVSGSEQGAMFACVAFVEMLSVGVSFTVFNSIYAAT-----------LSWFSGFSFLLA 432

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BLAST of slc46a-4 vs. Ensembl Xenopus
Match: slc46a1 (solute carrier family 46 (folate transporter), member 1 [Source:NCBI gene;Acc:100145771])

HSP 1 Score: 72.7886 bits (177), Expect = 6.174e-13
Identity = 91/422 (21.56%), Postives = 188/422 (44.55%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAA--IGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIF---------SAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLS------FGLLFNIQMI----YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQ 1593
            VE ++FL       +  +  Q+++ ++   + F  N      C  + S +T   Q + V+ L+ ++ + I+LG  +  LF+       + + GRR ++ +  IG  +++    +++++   +  F+    + G++G   ++ + CF+ +A+ S  ++R  R+   ++ + LG A  + S+  G+  K  G++ PF +   +++    Y  FC+E+S   +++K   +       +  F         + +  L  +++ LL+    ++G   A  +     +SYP+C +S  IGY  + E L          T L+  L  L +  +CL+       G + NI  +     A T   ++  +G    + +  P I+  LSK+     Q  LF  +  +E     L+ +V   LY  TL   Q
Sbjct:   34 VEPVLFLSMFALALQGPLTTQYLWDRLSADIGF--NGTRILDCTVNGSKSTGALQQE-VETLTSHWSLYINLGGFLVGLFSVMLLGPWSDKVGRRPVLFFPCIGLALQAALYLVVMYQELHVAYFLIGRFISGISGDFNMILAGCFAYIADVSDRQSRTFRVA--ILEACLGIAGMVASIIGGHWRKAQGYINPFWLVFAVNLFTAVYVYFCVEES---VKDKKPARLFTHRHYQTFFRLFTVSGENNRRRKLCLYSLALLVVVTVHMG---AKNLFVLYELSYPLCWDSDLIGYGSAAEHL----------TYLSS-LAGLRLFQLCLADSWVAEMGFISNISGLVVISLASTTPVMFTGYGLRFFAMATTPVIRSKLSKMVEEGEQGALFSSVACVEGLSYLLATAVFNSLYPATLHFMQ 433

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BLAST of slc46a-4 vs. Ensembl Xenopus
Match: SLC46A3 (solute carrier family 46 member 3 [Source:NCBI gene;Acc:100492828])

HSP 1 Score: 60.8474 bits (146), Expect = 3.293e-9
Identity = 82/412 (19.90%), Postives = 178/412 (43.20%), Query Frame = 1

Query:  442 VMKQFIYHK--VKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASK-VENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKS--KPEIEEKLDLKPTILE-FSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSY----PICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLS 1647
            +++Q++Y +  ++   D F N  + + C  +QS+    +Q +  +  SL +   + L   I  L  +   +    R GR+  I+   +G  +  +  C + F    L        + G  GG       CFS +A+ SK  + +N+RI    +   + + +  +++GY I+  GF   F++  ++ +  + Y  F LE++  + E ++ +  K    E F+ +    +N      VVL +    ++    A+     +F  Y    P+C +S+ +G+  +       +G      + ++ L +  ++ I ++  +   I + ++ T  ++ +     + ++   P ++  +SK+   N Q  LF  +  LE   G L+ ++   +Y  T           +  F G +F+LS
Sbjct:   37 LIQQYVYSRMLIEGSSDGFINGNNISHCETNQSDPAYIHQKEVQKRASL-FSSTLDLSALIPSLVMALILVSYGDRHGRKASILLPCLGALLSVLIYCAIAFFTLPLAVLYLSYVISGFMGGFATFIGGCFSYVADLSKDAQKKNIRIAFVDMVLGVSSGLAGIASGYFIRELGFNWSFLIPGLLHIINICYICFFLEETVQRSEFQQPVLSKEGFTELFTGVFLLFRNASCKKRVVLTLLLLAFMLYLLANFGAVSLFTLYELDAPLCWDSVLVGWGSAFSTFCF-VGSFFGVYLFSRCLKDAYIVFIGMTSWIGGIILVAFSTTTIAMMLVRIPLLFAAMPLPVLRSIMSKVVLENEQGALFACIACLESITGVLTITIFSAVYAAT-----------VMWFPGFSFLLS 435

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BLAST of slc46a-4 vs. Ensembl Mouse
Match: Slc46a1 (solute carrier family 46, member 1 [Source:MGI Symbol;Acc:MGI:1098733])

HSP 1 Score: 62.003 bits (149), Expect = 1.255e-9
Identity = 101/456 (22.15%), Postives = 194/456 (42.54%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQS--NATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRI--------VCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEK----LDLKPTILEFSEIIFSAKNI-------LSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGI-STLNHHLKLK 1692
            VE L+FL     + +  +  Q+++H+       F  E+  N   + ++  N +      +V+ L+ ++ + +++G  +  LF S      + R GRR L++ + +G  +++V    ++     +  F+    L  L G    L +  F+ +A+ S   +R  R+        V G +AS LG        G+ ++  G+  PF +A  + +    Y  FC  ++  E +      L    +I     +    K+        L+ F VV + FG        A +IL    +S P+C +S  IGY  + + L      +L   +L   L +  V  I L+F +L  +   +A     ++  +G   LS    P I+  LSKL + + Q  LF  +  +      ++  +   +Y  TL   +   +L+     G+ F+ ++LIG+   +N H + +
Sbjct:   25 VEPLVFLANFALVLQGPLTTQYLWHR-------FSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLG--------GHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFG--------AQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLT-SLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLL---GAGLLFIPAILIGVLEKVNPHPEFQ 453

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BLAST of slc46a-4 vs. Ensembl Mouse
Match: Slc46a2 (solute carrier family 46, member 2 [Source:MGI Symbol;Acc:MGI:1353616])

HSP 1 Score: 60.4622 bits (145), Expect = 4.082e-9
Identity = 88/411 (21.41%), Postives = 181/411 (44.04%), Query Frame = 1

Query:  490 FENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKT-YGFLPPFIVATIISVGCVSYPIF------CLEKSKP-EIEEKLD-----------LKPTILEFSEIIFS----AKNILSSFTVVLLMFGFFYVGETAAS---EILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILI-CLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFM 1641
            F++E +G + NYS + +  +YQ D+ Q    N+ +  +L   +  L ++     ++ R+ R+I I  + +GF +  +   L +  +W ++       L+GL G     +S   +L +       R++R++   +   L    GS+++G++ K   G     ++ T  SVGC ++ +F       + +SKP ++   +D           L P   +   +  +     K   S   VV L+F    + + AA    +++    +  P+  N +Q+GY ++   ++  I   L   + ++   +  +I+I  LSFG    + + + K     YIA    + +      I+  +SKL   +    +F+ L +     G ++ ++   +YQ TL+ +      I TCF   +F+
Sbjct:   48 FKSE-AGGSSNYSANQSLVEYQEDQQQKAISNFNIIYNLVLGLTPLLSAYGLGWLSDRYHRKISICTAMLGFLLSRIGLLLKVMLDWPVEVMYGAAALNGLCGSFSAYWSGVMALGSLGCSEGRRSVRLILIDLVLGLAGFSGSMASGHLFKQIVGHSAQGLLLTACSVGCAAFALFYSLFVLKVPESKPNKVHPTVDTVSGMMGTYRTLDPDQQDKQNVPRNPRTPGKGKSSQREVVALLFVGAIIYDLAAVGTVDVMALFVLKEPLHWNQVQLGYGMASGYIIF-ITSFLGVLVFSRCFRDTTMIIIGMLSFGS-GALLLAFVKETYMFYIARAIMLFALIPITTIRSAMSKLIKDSSYGKIFVILQLCLTLTGVVTSTIYNKIYQLTLDKF------IGTCFVLSSFL 449

[Close]

BLAST of slc46a-4 vs. UniProt/SwissProt
Match: sp|Q6DCX5|PCFT_XENLA (Proton-coupled folate transporter OS=Xenopus laevis OX=8355 GN=slc46a1 PE=2 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 1.757e-13
Identity = 95/423 (22.46%), Postives = 190/423 (44.92%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAA--IGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSA-------------KNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLS------FGLLFNIQMI----YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLE 1584
            VE ++FL       +  +  Q+++ ++   + F      G A N S+S   E+    +V+ L+ ++ + I+LG  +  LF+       + + GRR +++   IG  +++    L++++   +  F+    + G++G   ++ + CF+ +A+ S  ++R  R+   V+ + LG A  + S+  G+  K  G++ PF +   +++    Y  FC+E+S   +++K   KP  L F+   + +             +  L  +++ LL+    ++G   A  +     +SYP+C +S  IGY  + E L          T L+  L  L +  +CL+       G + NI  +     A T   ++  +G    + +  P I+  LSK+     Q  LF  +  +E     L+  +   LY  TL 
Sbjct:   27 VEPVIFLSMFALALQGPLATQYLWDRLSADIGFNGTRTVGCAMNGSKSAGPEQ---QEVETLTAHWSLYINLGGFLVGLFSVMLLGPWSDKVGRRPVLMLPCIGLALQAAVYLLVMYQELHVGYFLIGRFISGISGDFNMILAGCFAYIADVSDRQSRTFRVA--VLEACLGIAGMVASIIGGHWRKAQGYINPFWLVFAVNLFTALYVYFCVEES---VKDK---KPARL-FTHRHYQSFFRLFTVQGENNRRRKLFLYSLALLVVVTVHMG---AKNLFVLYELSYPLCWDSDLIGYGSAAEHL----------TYLSS-LAGLRLFQLCLADSWVAEMGFISNISGLVVISLASTTPIMFTGYGLRFFAMATTPVIRSKLSKMVEEGEQGALFSSVACVEGLSFLLATGLFNSLYPATLH 423

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BLAST of slc46a-4 vs. UniProt/SwissProt
Match: sp|Q5F4B8|S46A3_CHICK (Solute carrier family 46 member 3 OS=Gallus gallus OX=9031 GN=SLC46A3 PE=2 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 2.417e-12
Identity = 101/457 (22.10%), Postives = 194/457 (42.45%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDK-------VQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVE-NRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASE------ILYYIFMSY------------------PICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMI-YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLS 1647
            RK+  VE ++F+Y       S V++QFIY K+      +E E +  A +   S+  E+ +S         +Q  +  + M + L  ++  L  +   +      GR+  ++   IG  I  +   ++ + +W          + GL G         F+ +A+    E  +  RI    +   + + +  +S+GY ++  GF   F  A+++ V  + Y  F L+ +   I E     P  L + E      ++  +F+ V ++F      +TA S+      +L +IFM+Y                  P+C   + IGY  +     +++   L   + +K L ++ ++ I + F  +  I M  +AKT   +++    ++ S    P ++  LSK+  P+ Q  +F  +  LEV  G +S SV  ++Y  T           +  F+G +F+LS
Sbjct:    2 RKVLLVEPVIFIYIFASSLTSPVVQQFIYRKL------WEEEYNSTAISSDNSSHCERNKSSPTYVMEKAIQEKTSFFNMQLDLTGAVPSLIVAFIIVANGDHQGRKKSLVLPSIGALIADIFLTIVSYFSWPTSVLFLATFISGLFGSMATFLGGGFAYIADQCHDEKQKTTRIAVIDLIFGVVSGLAGLSSGYFLREMGFTWTFATASLLHVVNIIYITFFLQDTV-HISEFQQQAP--LSYKE------HLKETFSGVYMLF------KTAPSKKRILIIVLLFIFMTYLFTMFGGSSLFTLYELDEPLCWTEVYIGYGAA-AFTSISLTSFLGVYLFSKCLKDIYIVFIGI-FSYIGGIVMAAFAKTTLLMFLVRVPSLFSIMPIPVLRSMLSKVVLPSEQGAVFACIACLEVLTGTISLSVFNVIYAAT-----------VAWFSGFSFLLS 424

[Close]

BLAST of slc46a-4 vs. UniProt/SwissProt
Match: sp|Q5EBA8|PCFT_RAT (Proton-coupled folate transporter OS=Rattus norvegicus OX=10116 GN=Slc46a1 PE=2 SV=1)

HSP 1 Score: 65.855 bits (159), Expect = 5.304e-10
Identity = 103/454 (22.69%), Postives = 194/454 (42.73%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRI--------VCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEK----LDLKPTILEFSEIIFSAKNI-------LSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGI-STLNHHLKLK 1692
            VE L+FL     + +  +  Q+I+H++   L +       N  N S     ++     V+ L+ ++ + +++G  +  LF S      + R GRR L++ + +G  +++V    ++     +  F+    L  L G    L +  F+ +A+ S   +R  R+        V G +AS LG        G+ ++  G+  PF +A  + +    Y  FC  ++  E +      L    +I++   +    K+        L+ F VV + FG        A +IL    +S P+C +S  IGY  + + L      +L   +L   L +  V  I L+F +L  +   +A     ++  +G   LS    P I+  LSKL + + Q  LF  +  +      ++  +   LY  TL   +   +L+     G+ F+ ++LIG+   +N H + +
Sbjct:   25 VEPLVFLANFALVLQGPLTTQYIWHRISTELGYNGTRHRENCGNQSADPVLKE-----VETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLQLHIGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLG--------GHWLRAQGYANPFWLALAVLIVMTLYAAFCFGETVKEPKSTRLFTLRHHRSIVQLYVVPAPEKSRMHLALYSLAIFVVVTVHFG--------AQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLT-SLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSLYPATLNFMKGFPFLL---GAGLLFIPAILIGVLEKVNPHPEFQ 453

[Close]

BLAST of slc46a-4 vs. UniProt/SwissProt
Match: sp|Q6PEM8|PCFT_MOUSE (Proton-coupled folate transporter OS=Mus musculus OX=10090 GN=Slc46a1 PE=1 SV=1)

HSP 1 Score: 62.003 bits (149), Expect = 8.775e-9
Identity = 101/456 (22.15%), Postives = 194/456 (42.54%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQS--NATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRI--------VCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEK----LDLKPTILEFSEIIFSAKNI-------LSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGI-STLNHHLKLK 1692
            VE L+FL     + +  +  Q+++H+       F  E+  N   + ++  N +      +V+ L+ ++ + +++G  +  LF S      + R GRR L++ + +G  +++V    ++     +  F+    L  L G    L +  F+ +A+ S   +R  R+        V G +AS LG        G+ ++  G+  PF +A  + +    Y  FC  ++  E +      L    +I     +    K+        L+ F VV + FG        A +IL    +S P+C +S  IGY  + + L      +L   +L   L +  V  I L+F +L  +   +A     ++  +G   LS    P I+  LSKL + + Q  LF  +  +      ++  +   +Y  TL   +   +L+     G+ F+ ++LIG+   +N H + +
Sbjct:   25 VEPLVFLANFALVLQGPLTTQYLWHR-------FSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLG--------GHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFG--------AQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLT-SLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLL---GAGLLFIPAILIGVLEKVNPHPEFQ 453

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BLAST of slc46a-4 vs. UniProt/SwissProt
Match: sp|Q8CA03|TSCOT_MOUSE (Thymic stromal cotransporter protein OS=Mus musculus OX=10090 GN=Slc46a2 PE=1 SV=2)

HSP 1 Score: 60.4622 bits (145), Expect = 2.855e-8
Identity = 88/411 (21.41%), Postives = 181/411 (44.04%), Query Frame = 1

Query:  490 FENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKT-YGFLPPFIVATIISVGCVSYPIF------CLEKSKP-EIEEKLD-----------LKPTILEFSEIIFS----AKNILSSFTVVLLMFGFFYVGETAAS---EILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILI-CLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFM 1641
            F++E +G + NYS + +  +YQ D+ Q    N+ +  +L   +  L ++     ++ R+ R+I I  + +GF +  +   L +  +W ++       L+GL G     +S   +L +       R++R++   +   L    GS+++G++ K   G     ++ T  SVGC ++ +F       + +SKP ++   +D           L P   +   +  +     K   S   VV L+F    + + AA    +++    +  P+  N +Q+GY ++   ++  I   L   + ++   +  +I+I  LSFG    + + + K     YIA    + +      I+  +SKL   +    +F+ L +     G ++ ++   +YQ TL+ +      I TCF   +F+
Sbjct:   48 FKSE-AGGSSNYSANQSLVEYQEDQQQKAISNFNIIYNLVLGLTPLLSAYGLGWLSDRYHRKISICTAMLGFLLSRIGLLLKVMLDWPVEVMYGAAALNGLCGSFSAYWSGVMALGSLGCSEGRRSVRLILIDLVLGLAGFSGSMASGHLFKQIVGHSAQGLLLTACSVGCAAFALFYSLFVLKVPESKPNKVHPTVDTVSGMMGTYRTLDPDQQDKQNVPRNPRTPGKGKSSQREVVALLFVGAIIYDLAAVGTVDVMALFVLKEPLHWNQVQLGYGMASGYIIF-ITSFLGVLVFSRCFRDTTMIIIGMLSFGS-GALLLAFVKETYMFYIARAIMLFALIPITTIRSAMSKLIKDSSYGKIFVILQLCLTLTGVVTSTIYNKIYQLTLDKF------IGTCFVLSSFL 449

[Close]

BLAST of slc46a-4 vs. TrEMBL
Match: A0A0H3YJH7 (Slc46a-4 OS=Schmidtea mediterranea OX=79327 GN=slc46a-4 PE=2 SV=1)

HSP 1 Score: 932.169 bits (2408), Expect = 0.000e+0
Identity = 467/467 (100.00%), Postives = 467/467 (100.00%), Query Frame = 1

Query:  310 MNIEAETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEHQET 1710
            MNIEAETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEHQET
Sbjct:    1 MNIEAETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEHQET 467

[Close]

BLAST of slc46a-4 vs. TrEMBL
Match: A0A0H3YFD5 (Slc46a-3 OS=Schmidtea mediterranea OX=79327 GN=slc46a-3 PE=2 SV=1)

HSP 1 Score: 301.212 bits (770), Expect = 6.949e-92
Identity = 171/434 (39.40%), Postives = 274/434 (63.13%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDF-FENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIE-EKLDLKPTILEFSEIIFSA---------KNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFML 1644
            R+ FGVE L+  YG   L +++VM+QFIY++V +  +    N+     CN + S +++K ++DK+Q ++ +++M ISLG SIA + T+PF+ + + R+GRR++ +  G G F+KSV E L I+  W +  FIY+ET +GLTG    + S+ FS +A+ S    R  RI    I  A+GA + S+S+GYMI TY +  PF+ +T+ +  C+ YP+F +  SKP  +  K+++KP +  + ++   A         ++ILS   +VL++F F+ VGE +  ++     MSYPICM SIQIG    L I+ +N+G  LS  +LN+  ++LVVI++CL FG+ FN+QM +A +  + +IA GSN+LS SAFPF +G+LSK T    Q  LF GL ++E   G ++K +++  YQ+TL+ +   V++ + CF+ VAF+L
Sbjct:   34 RRFFGVEPLLLFYGFASLMQTTVMQQFIYYRVGIIYNITAPNQTLAFVCNRT-SGSSDKDKTDKLQEINSHFLMLISLGSSIASILTAPFYSVFSDRYGRRLMFLIPGTGIFVKSVLELLAIYYLWPITTFIYMETFYGLTGAYNFVISLGFSYVADRSGHGTRTCRIAFVGIMIAIGAFVASLSSGYMITTYRYFVPFLASTVAAFLCLIYPLFLMMDSKPISDLSKVNMKPIMAVWKQLTSLATVHKKQSRNESILS--ILVLIIFAFYNVGEMSGVDLQTPYLMSYPICMTSIQIGLYGILNIVAINLGAGLSTAMLNRCFSDLVVIVLCLIFGMAFNLQMAFATSPLAAFIATGSNLLSFSAFPFFRGFLSKRTKSTEQGALFGGLVLIETVCGAITKVLMLYFYQKTLQTFNGLVFIFIGCFSLVAFIL 464

[Close]

BLAST of slc46a-4 vs. TrEMBL
Match: A0A0H3YJM6 (Slc46a-2 OS=Schmidtea mediterranea OX=79327 GN=slc46a-2 PE=2 SV=1)

HSP 1 Score: 234.187 bits (596), Expect = 2.619e-66
Identity = 154/450 (34.22%), Postives = 243/450 (54.00%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFS--------AKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEH 1701
            R+   VE LM +Y +I   + +VM Q++Y++V   L+   N      CN + +  +EK ++DK+Q +     M I L  SI  + T+PF+ + + RFGR+++ I  G G F+KSV E L+I   W L  F+  E  +GL GG     S+ +S +A+ S  + R  R+    +   LGA + S+ +G  IK   +  P+I   ++++ C  YPIF L K  P+I    D K TI+   E + S         K   +   +V ++F F+YV E +   +     MSYPICM++IQ+    +  +L LN+G+ ++   L+K+ ++L ++  CL  G+ + +QM +A +V  +YIA  SN+ S SAFPFI+GY+SK   PN Q  LF GL + E   G ++K + I  Y+ T   +   VYL+LT F+ +A +L L      L    KLK E 
Sbjct:   39 RRCVTVEPLMLMYVVILYLQMTVMGQYVYYRVGKDLNLTTNGNLAYVCNRNVTGGSEKEKTDKLQEIYTYNTMFIQLSSSIFTILTAPFYSVFSDRFGRKLMFILPGGGAFVKSVIEILIIVYEWPLYIFVITEGFYGLFGGFNFATSLSYSYIADISTQKERTKRMGIMGVLMGLGALLVSLVSGIWIKYRNYKEPYIFTGVVALLCFLYPIFLL-KEPPKIN---DPKKTIISPIEQMKSIVKVYWDKPKEYRALLILVFVLFNFYYVSEMSGLSLSGTYLMSYPICMDTIQLSIFGASNMLALNLGIGITIIFLSKFFSDLFLVFFCLLSGIAYLLQMAFAVSVTQVYIAAASNLFSFSAFPFIRGYMSKRMGPNEQGALFGGLALSETVCGAITKVITIYFYRETFRIFHGMVYLLLTGFSVIACVLILF----ALPIDRKLKAEE 480

[Close]

BLAST of slc46a-4 vs. TrEMBL
Match: A0A401SAI9 (MFS domain-containing protein OS=Chiloscyllium punctatum OX=137246 GN=chiPu_0005820 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 3.399e-18
Identity = 101/444 (22.75%), Postives = 209/444 (47.07%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKV---KLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISL-----GFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIE-TLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILS--------SFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILI---CLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLS 1647
            +++F VE ++ LY + +L +  +M+Q+IY ++   +    + +NE   N+  Y   +    ++ + VQ LS ++ M ++L      F +  +  S      +  +GRR+ ++   IG  I S+    + + +W +  F++I   L    GG   ++   F+ +A+ S  E++N+R+    +   L   IG++++GY++ T GF   F++A++I+   V Y IF L++S     ++ +      +F EI     N+ +          +++LL F  + +    +  +     ++ P+C N++ IGY  S   L+  +   L   + ++YL +  ++LI    L+ G+   I  ++A     +++     + +    P ++  +SK+ +P  Q  LF  +  LE     +S  V   +Y  T+             FTG +FML+
Sbjct:   23 KRLFLVEPVVALYTLPNLADELLMQQYIYRRIWTRETNSSYVQNE--NNSYCYQNHSDPVYFKQEVVQELSSHFFMYVTLIKFLPNFIVTFVLGS-----YSDHYGRRLSLLLPTIGALISSLAFLAMTYFSWPIH-FLFIPVALSACFGGFTTVFGGAFAYVADVSSSEHKNMRMALLDMIVGLMGGIGTITSGYLLNTLGFNWLFLIASLINFANVVYIIFFLDESVQVSRDEQNEGSGNGKFREIFAGILNLWTGSNFRKRVQISLMLLTFSVYALASFGSGGLFTLYELNAPLCWNAVLIGYG-SAAGLITFLTSFLGVALFSRYLEDHFIVLIGTLSLAGGM---IVAVFATITLVMFLVRLVCLFAVMPLPVLRSMMSKIVSPKDQGVLFACVACLENLSATISSVVFNNVYAATIHG-----------FTGFSFMLA 443

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BLAST of slc46a-4 vs. TrEMBL
Match: V3ZU71 (Uncharacterized protein (Fragment) OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_73586 PE=4 SV=1)

HSP 1 Score: 97.4413 bits (241), Expect = 5.319e-18
Identity = 108/433 (24.94%), Postives = 188/433 (43.42%), Query Frame = 1

Query:  385 FGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVS------GNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANAS-KVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCL-----EKSKPEIEEKLDLKPTI-LEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYL-NELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFM 1641
            F V F + LY +  ++   +  Q+I  ++ L L    N  +       NACN S     +     +   LSL Y +   +      L   P    +    GRRIL I   +G F+K V   L+++ + +L+       + GL G    +    F+  A+ +   +NR + I C     A+ A++G++S+G++IK+ G+  P ++  I +   ++   FCL     EK +PE      +K      FS     +K +L S  + +  FG   V    + E +Y   +  P C NS++IGY  +L + V     ILS   L  Y  +E + IL         +I ++               ++ SS  P  +  +SK+T P  Q  LF  + ++E      S S+  ++Y  T+E ++  V+ ++  F  +A M
Sbjct:    1 FVVGFGIILYMLSAISIVPLTSQYIVSRLSLSLKV-NNSTNISVVNVSNACNGSILGPEQIKIQKEASLLSLYYALTSGVAAIAINLILGPLSDFI----GRRILFIIPIVGLFLKCVITSLIVYFDLNLNLMYLASAVDGLCGSYYAILVASFTYSADVTVPGKNRTVAIACMEGCLAVAASVGALSSGFLIKSTGYFYPVLMFAIAAAINLTLTFFCLPETLTEKKQPEKSPLYHIKKVFGFYFSN---GSKRLLYSVLMGMFFFGVVVVLGRTSLETIYQ--LGEPFCWNSVKIGYFGALRLTVQFSCSILSIKFLQNYFKDEYISIL---------SIPVV--------------GIIGSSTVPIARSLMSKMTPPEKQGALFASIAIVETVCNSASNSLYNLVYNATVEHFKGAVWFMMAGFCIIAIM 400

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BLAST of slc46a-4 vs. Ensembl Cavefish
Match: si:dkey-5g14.1 (solute carrier family 46 member 3-like [Source:NCBI gene;Acc:103033173])

HSP 1 Score: 58.5362 bits (140), Expect = 1.105e-8
Identity = 97/470 (20.64%), Postives = 203/470 (43.19%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKV--KLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLAN-ASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSK----PEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMF------GFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGI------STLNHHLKLKIEHQET*SNSDV 1728
            +K + VE ++ +Y         +++Q++Y ++  ++    +    + + C+ + SN T  +   +VQ  +  + M   L   I  L  +   +  + + GR+I II   +G  +  +    + F   +L   I    +  L GG   +   CFS +A+     + + LR+    +   L + +  +S+GY ++  GF  P + A  + +  + Y +F LE+S+       E+       I   +  I++   + S    VLL+F       F +      + +  Y+ ++ P+C + I IGY+ +L   V     +     L++ L ELV++ I +       + M +AKT   +++     VL+   FP ++  +SK+ + + Q  LF  +  ++     L+ +    +Y  T+  +    +L+     G+  +   L+GI         ++   L +E  +T  N+ V
Sbjct:    2 KKFYFVEPVVAVYSFACFLLYPLVQQYVYRRLWQEITNTSYPALDTSSRCDTNSSNHTSHHY--EVQQAASLFSMYSELFSLIPSLIATLVLVAYSDQRGRKITIILPLVGSLVYCLAFLAVSFFELNLYLLIIASFVSSLFGGIGTMLGGCFSYVADLCEDGKQKTLRMAGVDMVIGLFSGVALISSGYFLRETGFNWPLVTAGTVHLVNLLYSVFFLEESRVIESSVAEDNRTCGEAIRRLTFGIYNLFALGSRRRNVLLVFLITIISTFSFANFGGLTVVTLYV-LNEPLCWSEILIGYASALSTTVFVTSFV-GVYFLSRCLPELVIVFIGMLSVFTGMVMMAFAKTTLMMFLVRIPMVLAIMPFPVLRSMMSKVVSKSEQGALFAWVAFVDSLSTNLASAAFNSVYSSTVAWFPGFAFLLA---AGICLIPMALLGILRCLQLREEDNTENLLVEDTQTTENAPV 464

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BLAST of slc46a-4 vs. Ensembl Cavefish
Match: slc46a3 (solute carrier family 46 member 3 [Source:ZFIN;Acc:ZDB-GENE-100105-2])

HSP 1 Score: 55.4546 bits (132), Expect = 1.133e-7
Identity = 97/460 (21.09%), Postives = 195/460 (42.39%), Query Frame = 1

Query:  442 VMKQFIYHKVKLCLDFFENEVSGNA--CNYSQSNATEKYQS----DKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSL--------LANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCL-EKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFG------------------FFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQM-IYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSL---LIGISTLNHHLKLKIEHQET 1710
            +++Q+IY ++         ++SG+    N +QS+ +  Y +      VQ  + ++++   L F +  LFTSP  +  +   GR+  ++   +G    +    ++   + +L   +    L GL GG   L   CFS         LA    V    L +V GV++      +GS+ TG+ I+  GF  PF+ A+I+ +  + Y +  L E     +        +++E   +   A+ +      V L+F                   F+ V       I     ++ P+C N + + Y  +L  L+  +       +L+++L +  + L+ L   +   + M  +AKT   +++     +LS    P ++  +SKL   + Q  LF  +  +E+    L+  V   +Y  T           ++ F+G +F+L+    +I I+ +   L L+++ +E+
Sbjct:   24 LLQQYIYRRLW-------QQLSGHPYPSNQNQSHCSSNYTNLSLQQAVQTETSHFLLQSELCFILPSLFTSPLLVSYSDYGGRKSAMVPPLLGDLFFTFHYFIVSRFSLNLSYVLAAAFLTGLLGGPTTLTGGCFSYVADYCREELAGQKTVRMARLDMVLGVLS-----GLGSLCTGFFIRAAGFSWPFLCASILHLLNLIYVLIILKEPPGQNLPPSPSSPGSVIEPPRLS-QAQAMTGRLQGVYLLFAASTRRRRTVLLLLLTAYIFYKVSNMGGMSIFILYELNAPLCWNEVLVSYGSALSTLIY-LSSFTGVALLSRWLPDAPIALLGL-LSIAVGLSMAAFAKTTLLMFLVRLPLLLSMMPAPVMRAMMSKLVLSSEQGALFACVAFVEMLSMGLAFPVFSSVYAAT-----------ISWFSGFSFLLAAGVTIIPITLIGCVLWLRLDVEES 457

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Query:  442 VMKQFIYHKVKLCLDFFENEVSGNA--CNYSQSNATEKYQS----DKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSL--------LANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCL-EKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFG------------------FFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQM-IYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSL---LIGISTLNHHLKLKIEHQET 1710
            +++Q+IY ++         ++SG+    N +QS+ +  Y +      VQ  + ++++   L F +  LFTSP  +  +   GR+  ++   +G    +    ++   + +L   +    L GL GG   L   CFS         LA    V    L +V GV++      +GS+ TG+ I+  GF  PF+ A+I+ +  + Y +  L E     +        +++E   +   A+ +      V L+F                   F+ V       I     ++ P+C N + + Y  +L  L+  +       +L+++L +  + L+ L   +   + M  +AKT   +++     +LS    P ++  +SKL   + Q  LF  +  +E+    L+  V   +Y  T           ++ F+G +F+L+    +I I+ +   L L+++ +E+
Sbjct:   24 LLQQYIYRRLW-------QQLSGHPYPSNQNQSHCSSNYTNLSLQQAVQTETSHFLLQSELCFILPSLFTSPLLVSYSDYGGRKSAMVPPLLGDLFFTFHYFIVSRFSLNLSYVLAAAFLTGLLGGPTTLTGGCFSYVADYCREELAGQKTVRMARLDMVLGVLS-----GLGSLCTGFFIRAAGFSWPFLCASILHLLNLIYVLIILKEPPGQNLPPSPSSPGSVIEPPRLS-QAQAMTGRLQGVYLLFAASTRRRRTVLLLLLTAYIFYKVSNMGGMSIFILYELNAPLCWNEVLVSYGSALSTLIY-LSSFTGVALLSRWLPDAPIALLGL-LSIAVGLSMAAFAKTTLLMFLVRLPLLLSMMPAPVMRAMMSKLVLSSEQGALFACVAFVEMLSMGLAFPVFSSVYAAT-----------ISWFSGFSFLLAAGVTIIPITLIGCVLWLRLDVEES 457

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BLAST of slc46a-4 vs. Ensembl Cavefish
Match: si:ch211-262i1.4 (si:ch211-262i1.4 [Source:ZFIN;Acc:ZDB-GENE-140106-10])

HSP 1 Score: 49.6766 bits (117), Expect = 5.963e-6
Identity = 68/262 (25.95%), Postives = 119/262 (45.42%), Query Frame = 1

Query:  472 KLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTS-PFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLD-AFIYI-ETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVS--YPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGY 1242
            KL   FFE  ++     Y+ S  T   Q D+ Q  S  + +  S+  ++A + ++ P   +  RR G ++ +I S +G  +  +C  LL+F  W L   F+++   ++GL+GGA   ++   +L A +SK  +R L++   ++  A    +G + +GY+ +  G     ++   IS   VS  Y  F L  S    E+K  L            +A  +L S  V+      F +G   A  IL    +  P+  +S+  GY
Sbjct:   16 KLGTSFFEMSLTLTV--YNVSLETADGQVDQAQAASSRFFLIHSIICTVAAMLSTVPLGRVADRR-GPKVFLIMSQLGS-VMGMC-VLLVFLFWKLPLEFLFLGSAVYGLSGGAPAYWAGVVALAALSSKQRHRTLKLNVPLLLFA--GVLGGLLSGYVYQI-GHKGVVLIGMAISFSVVSLLYSTFLLSGSVQNSEDKELLLSRAGRSERTNRAAVGLLISAMVL------FMLGMIGAENILTLYVLKPPLSWDSVWAGY 263

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BLAST of slc46a-4 vs. Ensembl Sea Lamprey
Match: slc46a3 (solute carrier family 46 member 3 [Source:ZFIN;Acc:ZDB-GENE-100105-2])

HSP 1 Score: 75.0998 bits (183), Expect = 1.299e-14
Identity = 93/425 (21.88%), Postives = 192/425 (45.18%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSS----FTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNV-LSSSAFP--FIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFML 1644
            VE ++ L+       S + +Q+IY +     +F  N+ +G+ C+ + S+  ++ + +     SL  V    +GF  AVL  S    + +   GRR+++I   IG+ ++S+   L++     L        L G TGG   + +  F+ L + +   N N+R+ C  +   +   IG+V +G+M++  G+   ++   +I V C+ Y    LE++  +          +   + + F       S      ++L+ F F+ + E   S  +    M  P+C +++ +GY  ++   +  I   +  T+L++ L++  + LI +S    F + M     V++  + F   + L  +  P   ++  +SK   P+ Q  LF  +  LE+  G +   V   +Y  T+  +   V+L+ +    + F++
Sbjct:    7 VEPIVALFAFAVFLSSPLNQQYIYRRFG---NFSTNDSTGSTCSPNGSDVEDELEKEAQAAASLFQVRLDLVGFLPAVL-ASLVLGVYSDTSGRRLMMILPCIGYSLESIVYILIVSLELPLPWLYLGCLLRGATGGYASILAGSFAYLTDVANPANLNMRVACLDMLIGISGGIGAVISGHMLQAMGYAFVYLCVCLILVLCIIYVACVLEETITKDIHVRSCTTPLRATTTVPFVQPGGPGSKRWRLALLLVAFTFYLLAEIGGSLPVSLFEMKAPLCWDALLLGYGSAVGFAIF-ITSFVGVTVLSRCLSDPPIALIGIS---TFTVGMAMICGVQTTLMMFLVRLPLMFTIMPVAVMRSMMSKTVLPSEQGTLFSLVGSLELLAGIVGSVVFNNVYAVTVGWFACLVFLLSSAVAVIPFLI 423

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BLAST of slc46a-4 vs. Ensembl Nematostella
Match: EDO38916 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBG4])

HSP 1 Score: 66.6254 bits (161), Expect = 9.234e-12
Identity = 86/395 (21.77%), Postives = 172/395 (43.54%), Query Frame = 1

Query:  403 MFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNAC-NYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASAL---GAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSK-PE--IEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMF--GFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEV---FLGCLSKS 1551
            +++YGI  L    V++QF+Y K+     FF +  S   C N ++ N+T      +VQ  +    +GI++  S+  +  S      +   GR+  I+   IG  +++VC  ++++ +  +        L+G +G    L     + +A+++    R LR+    I  AL   G  +  +++G  I   GF  P+       V    Y IF + +++ P+   E+        L+    ++S         ++LL        V       ++    +  P+C ++  +GY  ++  LV+  G +     L K+++EL +  + L   +   +   ++ T   ++I     +L+ +  P  KG LS++ + + Q  LF  +  LE    F+G L+ S
Sbjct:    7 LYVYGI--LMHGPVIQQFVYSKIAKQKGFFYDPSSHTGCGNETRYNSTLHNLEQEVQATAAYVQIGITMFESLPSIVLSLMVGSWSDCHGRKPAILLPVIGSMLEAVCVLIVMYCDLDVYVLFIGALLNGCSGYLPTLLMGIMAYIADSTDESQRALRL---AIMEALVFTGGMVSQLTSGLWIDKLGFTGPYWFIFGCLVIAFFYTIFLVPETRFPDENTEKSRFFSCKTLKRIWKVYSTPRDGGRKNMLLLTLNDALTQVAIQGVGPVMTLYILHSPLCFSADDLGYFSAVRFLVMGFGAVFGLKFLVKWIDELSISRLGLLTTIGTYVLFGFSTTRAMVFIVGAVGLLNGAVAPVFKGMLSRIVSRDEQGALFSFVASLETLCSFIGALTLS 396

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BLAST of slc46a-4 vs. Ensembl Nematostella
Match: EDO42708 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0P7])

HSP 1 Score: 59.6918 bits (143), Expect = 1.903e-9
Identity = 74/407 (18.18%), Postives = 168/407 (41.28%), Query Frame = 1

Query:  394 EFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNAC-NYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPF-IVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVL--------------LMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFG-------------SNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEV 1527
            E ++FLY         V++Q++Y ++     F  +      C N +  NAT ++   +VQ L+    +GI +  ++  +  S          GRR  +    +G  ++S+   L+++  W +       +++GL G    +     + +A+ +  + R+LR+         GA +  +++G  I+ Y F+ P+  + + +S+ C+   I  + +S+P         P +++      S +++ + + V +              L  G   +     + ++    +  P+C +   +GY  +L  L + +G +L   +L ++L+             + NI  +   +  + YI FG             + +      P ++G +S++ + + Q  LF  +  LE+
Sbjct:   13 EIVVFLYAYGLFMHVPVIQQYVYSRIAKSKGFPYDAHKKTGCGNITILNATMQHIEQEVQSLASYVHLGIVMFAALPSVVMSLLIGSWTDSRGRRPALFLPALGSTLESIVVILVMYFEWPIYVLFVGASINGLCGSFTTIIMGTMAYIADTTHEDQRSLRLAILEFMVFFGAMVSQLTSGLWIEKYSFIIPYWFILSCLSLSCILV-IAIVPESRP---------PDVIQNKTAFCSCRSLQNVYKVYMTPREGGRRNLFLLTLSSGVTNLILQGVAGVIVLFVLHTPLCFSPKLVGYLSALRYLSIGVGAVLGIKVLGRWLS-------------VINISRVGMLSTMASYILFGFSTKIFIVFLVPFAGLFMGCVVPILRGIMSRIVSQDEQGALFSAVASLEM 396

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BLAST of slc46a-4 vs. Ensembl Nematostella
Match: EDO32892 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STS4])

HSP 1 Score: 58.9214 bits (141), Expect = 3.117e-9
Identity = 80/393 (20.36%), Postives = 168/393 (42.75%), Query Frame = 1

Query:  391 VEFLMFLYGIIDLTESSVMKQFIYHKV---KLCLDFFENEVSGNACNYSQ-SNATEKYQ--SDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPE-IEEKLDLKPTILEFSE---IIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNV-----LSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLE 1524
            VE ++F Y    +    V++Q+I+ ++   K     + N  S   C   Q +N++E+      +VQ  +    MG+ L  S   L  +      + R GRR  +     G  ++S    ++++    +   +  E ++G  G    +    FS +A+ ++   R  R+      + +   +  +++G+ I   GF  P+ +  I++   + Y  F L +S+ + + EK  ++   L+      +IF+        T+ +++ G   V       +     +  P+C N+I IGY + L   V  +G +L    L   L+E  ++ + +   +   + M +  + K++++  G ++     L     P I+  +SK+   + Q  LF  +  LE
Sbjct:    5 VEPVIFCYAFGIILHVPVIQQYIHQRLSEGKGLTYEYNNTDSRTTCEPIQMANSSEETLELQKEVQAEASYMQMGLVLSVSTPSLLVALLLGAWSDRAGRRRAMAMPIFGSAVESAIILVIMYFELPVTFLLLAEFINGSCGFFPTMVLSVFSYIADITEESQRAFRLGILEAIAFISGMLSHLTSGWWINNLGFRAPYWLLLILNTFALLYVTFILPESRAKHVMEKSKVRVLSLDHIRAIVMIFTKSRDPQRMTIFMVISGLMIVSSIGFGSVFVLYALDRPLCCNAILIGYYLGLSFFVQAVGAVLGLKYLRLCLSETALMQVGMVSIISSLVVMAFVTSKKTLFV--GKSLPFVACLGGVPTPTIRAMMSKMVDADGQGALFAAVASLE 395

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BLAST of slc46a-4 vs. Ensembl Nematostella
Match: EDO48562 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIS8])

HSP 1 Score: 52.373 bits (124), Expect = 3.885e-7
Identity = 84/426 (19.72%), Postives = 180/426 (42.25%), Query Frame = 1

Query:  343 RP-TQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVS--YPIFCLEKSKPEIEEKLDLKPTILEFSEIIF----SAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILS---GTILNKYLNELVVILICLSFGLLFNIQMI-YAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLED 1587
            RP + L  P    +   VE  +F Y    + E  V++Q++Y +    L    N  +   C+ +  N+T +  +D VQ  +  Y++  +L   +  + T+      + + GR+ L++    G  + +      ++ +  L   I    ++G+ G    +     + +A+ +  + R +++      + L   +G  S+G  I   G+   F    I+S+  ++  Y +F L +S P+   +   K   LE  + ++      ++      V+ L+  FF   +   + +       YP+C ++  +GY +   + V   G +L    G+++   L       I   F L+  + MI +++T   ++++  +N+ S    P I+  +S++     Q  LF  L  LE      S+ +   LY  ++ +
Sbjct:    6 RPISWLKNP---HRAVTVEITIFFYIAGMILELPVLQQYLYERAAKELKI-NNTSNTTICSPNDLNSTGQSANDAVQEKASQYILAYNLALQLPAVLTACLLGTWSDKNGRKPLMLIVAFGAIVDASVALFTVYTDGPLYPLIIGGGINGVMGFYPTMVLALLAYIADTTPSKRRAIKLAVLEALAFLSGTLGHFSSGIYIHHLGYKATFW--GILSLHLINFIYLLFFLPESMPKQRIEQSGKCLTLEQVKSVYMVYLKKRDGRWILCVLSLLSVFFLFAQYIVTTLGVLYGKRYPLCWSAELVGYFLGTLLCVKAFGAVLGIWLGSLMK--LTNYTAAQIGTLF-LIAGLTMIGFSQTTFLMFMSCVANLFSGVPQPCIRAQMSQMVGKEEQGALFAILASLESLTNFTSQLIFNPLYAWSIAN 422

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BLAST of slc46a-4 vs. Ensembl Nematostella
Match: EDO27580 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T8V4])

HSP 1 Score: 50.0618 bits (118), Expect = 5.607e-7
Identity = 54/220 (24.55%), Postives = 101/220 (45.91%), Query Frame = 1

Query:  379 KIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLI-FRNWSLDAFIYIETLHGLTGG-AMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKS 1032
            K   VE ++FLY       S +++Q  Y K+  C + +   V  N  +Y         + + VQ  + N++   +L  ++  + +S      + R GR+ ++I   +G  + ++   L + F + +++  I    + G  GG A  L SV FS +A+ +   +R LRI        LG ++G +  G M+   GF+  F +A  ++    +Y  F L +S
Sbjct:    8 KSITVEPVLFLYMFCTFMSSPLLQQLAYRKI--CKEHYNTSVCNNLSDYQN-------EQNYVQTSTSNWMRYQALALALPSIASSLVLGAWSDRVGRKAIMILPPVGNILMNINYMLNVHFFSLNVNYLIIGIVIAGTFGGFATTLLSV-FSYMADITDKSHRTLRISILESMVFLGGSVGELVAGVMLDHSGFMATFGLALGLNCCIAAYVTFILPES 217

[Close]

BLAST of slc46a-4 vs. Ensembl Medaka
Match: si:dkey-5g14.1 (solute carrier family 46 member 3 [Source:NCBI gene;Acc:101171853])

HSP 1 Score: 68.1662 bits (165), Expect = 1.082e-11
Identity = 115/465 (24.73%), Postives = 208/465 (44.73%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSD---KVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIET--LHGLTGGAMILYSVCFSLLANASKVE-NRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKS--KP-------EIEEKLDLKPTIL----EFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFM-LSLLIGISTLNHHLKLKIEHQET 1710
            ++++ VE ++ LY         +++Q+IY ++ L L      +S N+   + SN++   Q+D   +VQ  +  + M   L  +I  L  +   +  + R GR+I II   IG  I +     L    + L+ ++ I +  L  L GG       CF+ +A+  K E  R LR+    +   L + + ++STGY ++  GF  PF+ + +     + Y IF LE++   P       E   +  LK  +      FS +    K +L+    +   F F YVG  +   ++    ++ P+C N + IGY  +L   V          +    + +L++IL+ +       I M +AKT   ++I     +LS   FP ++  +SK  + + Q  LF  L+ LE     +S  V   +Y  T+  Y   V+++     G+ F+ LS L  ++ +   +  +I   ET
Sbjct:    2 KRLYLVEPVVALYAFSSFLIYPLVQQYIYRRLWLQLTNTAYPISSNSSRCAPSNSSSN-QTDFHKEVQKQASLFSMYSELLSTIPSLIVTLLLVAYSDRGGRKITIIMPLIGSLIYA--SSFLTVSFFELNIYLLIGSSFLSSLFGGLGTFLGGCFAYIADLCKNERQRTLRMAGVDMMIGLLSGVAAISTGYFLRAAGFNWPFLTSLLCQCLTLLYAIFILEETVKAPNEGDIFDESTRRHALKYMVCGVYQTFSGLTSKCKILLALMMFIFTSFSFAYVGGIS---LVTLYELNEPLCWNEVLIGYGSALSTTVFLTSFAGVAALTYCRVPQLLIILLGILSVASGMILMSFAKTTVLMFIVRIPMLLSIMPFPVLRSMMSKNISKSEQGALFACLSFLESLTNNVSSGVFNSIYAATVAWYPGFVFIL---SAGLCFIPLSALGVVALIGTDVSTEIGRPET 457

[Close]

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSD---KVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIET--LHGLTGGAMILYSVCFSLLANASKVE-NRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKS--KP-------EIEEKLDLKPTIL----EFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFM-LSLLIGISTLNHHLKLKIEHQET 1710
            ++++ VE ++ LY         +++Q+IY ++ L L      +S N+   + SN++   Q+D   +VQ  +  + M   L  +I  L  +   +  + R GR+I II   IG  I +     L    + L+ ++ I +  L  L GG       CF+ +A+  K E  R LR+    +   L + + ++STGY ++  GF  PF+ + +     + Y IF LE++   P       E   +  LK  +      FS +    K +L+    +   F F YVG  +   ++    ++ P+C N + IGY  +L   V          +    + +L++IL+ +       I M +AKT   ++I     +LS   FP ++  +SK  + + Q  LF  L+ LE     +S  V   +Y  T+  Y   V+++     G+ F+ LS L  ++ +   +  +I   ET
Sbjct:    2 KRLYLVEPVVALYAFSSFLIYPLVQQYIYRRLWLQLTNTAYPISSNSSRCAPSNSSSN-QTDFHKEVQKQASLFSMYSELLSTIPSLIVTLLLVAYSDRGGRKITIIMPLIGSLIYA--SSFLTVSFFELNIYLLIGSSFLSSLFGGLGTFLGGCFAYIADLCKNERQRTLRMAGVDMMIGLLSGVAAISTGYFLRAAGFNWPFLTSLLCQCLTLLYAIFILEETVKAPNEGDIFDESTRRHALKYMVCGVYQTFSGLTSKCKILLALMMFIFTSFSFAYVGGIS---LVTLYELNEPLCWNEVLIGYGSALSTTVFLTSFAGVAALTYCRVPQLLIILLGILSVASGMILMSFAKTTVLMFIVRIPMLLSIMPFPVLRSMMSKNISKSEQGALFACLSFLESLTNNVSSGVFNSIYAATVAWYPGFVFIL---SAGLCFIPLSALGVVALIGTDVSTEIGRPET 457

[Close]

BLAST of slc46a-4 vs. Ensembl Medaka
Match: si:dkey-5g14.1 (solute carrier family 46 member 3 [Source:HGNC Symbol;Acc:HGNC:27501])

HSP 1 Score: 66.2402 bits (160), Expect = 4.094e-11
Identity = 106/434 (24.42%), Postives = 198/434 (45.62%), Query Frame = 1

Query:  442 VMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSD---KVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIET--LHGLTGGAMILYSVCFSLLANASKVE-NRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKS--KP-------EIEEKLDLKPTIL----EFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVIL---ICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILT--CFTGVAFMLSLLIGISTL 1671
            +++Q+IY ++ L L      +S N+   + SN++   Q+D   +VQ  +  + M   L  +I  L  +   +  + R GR+I II   IG  I +     L    + L+ ++ I +  L  L GG       C++ +A+  K E  R LR+    + S L + + ++STGY ++  GF  PF+ + +     + Y IF LE++   P       E   +  LK  +      FS +    K +L+    +   F F ++G    S +  Y  ++ P+C N + IGY  +L   V  I       +    + +L+++L   + ++ G+   I M +AKT   ++I     +LS+  FP ++  +SK  + +    LF   + LE+    +S  V   +Y  T+  Y   V+ +    CF  +++ + +++  S L
Sbjct:   24 LVQQYIYRRLWLQLTNTTYPISSNSSRCAPSNSSSN-QTDFHKEVQKQASLFSMYSELLSTIPSLIVTLLLVAYSDRGGRKITIIMPLIGSLIYA--SSFLTVSFFELNIYLLIGSSFLSSLFGGLGTFLGGCYAYIADLCKNERQRTLRMAGVDMMSGLLSGVAAISTGYFLRAAGFNWPFLTSLLCQCLTLLYAIFILEETVKAPNEGDIFDESTRRHALKFLVCGVYQTFSGLSSKCKILLALMMFIFTSFSFAFIG--GISLVTLYE-LNKPLCWNEVLIGYGSALSTTVSLISFAGVAALTYCRVPQLLIVLLGILSVASGM---ILMSFAKTTVLMFIVNIPMLLSNMPFPVLRSMMSKNISKSEHGALFACFSFLEILTINVSFGVFNSIYAATVAWYPGFVFSLSAGLCFIPLSWNMVIIVTFSAL 448

[Close]

BLAST of slc46a-4 vs. Planmine SMEST
Match: SMESG000065066.1 (SMESG000065066.1)

HSP 1 Score: 925.62 bits (2391), Expect = 0.000e+0
Identity = 463/467 (99.14%), Postives = 466/467 (99.79%), Query Frame = 1

Query:  310 MNIEAETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEHQET 1710
            MNI+AETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETL+GLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEI+FSAKNILSSFTVVLLMFGFFYVGETAASEILYYI MSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEHQET
Sbjct:    1 MNIQAETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLYGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEILFSAKNILSSFTVVLLMFGFFYVGETAASEILYYILMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEHQET 467

[Close]

BLAST of slc46a-4 vs. Planmine SMEST
Match: SMESG000065064.1 (SMESG000065064.1)

HSP 1 Score: 299.671 bits (766), Expect = 7.102e-95
Identity = 171/434 (39.40%), Postives = 273/434 (62.90%), Query Frame = 1

Query:  376 RKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDF-FENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIE-EKLDLKPTILEFSEIIFSA---------KNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFML 1644
            R+ FGVE L+  YG   L +++VM+QFIY++V +  +    N+     CN + S +++K ++DK+Q ++ +++M ISLG SIA + T+PF+ + + R+GRR++ +  G G F+KSV E L I+  W +  FIY+ET +GLTG    + S+ FS +A+ S    R  RI    I  A+GA + S+S+GYMI TY +  PF+ +T+ +  C+ YP+F +  SKP  +  K+++KP +  + ++   A         ++ILS   +VL++F F+ VGE +  ++     MSYPICM SIQIG    L I+ +N+G  LS  +LN+  ++LVVI +CL FG+ FN+QM +A +  + +IA GSN+LS SAFPF +G+LSK T    Q  LF GL ++E   G ++K +++  YQ+TL+ +   V++ + CF+ VAF+L
Sbjct:   34 RRFFGVEPLLLFYGFASLMQTTVMQQFIYYRVGIIYNITAPNQTLAFVCNRT-SGSSDKDKTDKLQEINSHFLMLISLGSSIASILTAPFYSVFSDRYGRRLMFLIPGSGIFVKSVLELLAIYYLWPITTFIYMETFYGLTGAYNFVISLGFSYVADRSGHGTRTCRIAFVGIMIAIGAFVASLSSGYMITTYRYFVPFLASTVAAFLCLIYPLFLMMDSKPISDLSKVNMKPIMAVWKQLTSLATVHKKQSRNESILS--ILVLIIFAFYNVGEMSGVDLQTPYLMSYPICMTSIQIGLYGILNIVAINLGAGLSTAMLNRCFSDLVVIALCLIFGMAFNLQMAFATSPLAAFIATGSNLLSFSAFPFFRGFLSKRTKSTEQGALFGGLVLIETVCGAITKVLMLYFYQKTLQTFNGLVFIFIGCFSLVAFIL 464

[Close]

BLAST of slc46a-4 vs. Planmine SMEST
Match: SMESG000065078.1 (SMESG000065078.1)

HSP 1 Score: 216.853 bits (551), Expect = 5.630e-64
Identity = 142/424 (33.49%), Postives = 228/424 (53.77%), Query Frame = 1

Query:  454 FIYHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLDLKPTILEFSEIIFS--------AKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLLFNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEH 1701
            ++Y++V   L+   N      CN + +  +EK ++DK+Q +     M I L  SI  + T+PF+ + + RFGR+++ I  G G F+KSV E L+I   W L  F+  E  +GL GG     S+ +S +A+ S  + R  R+    +   LGA + S+ +G  IK   +  P+I   ++++ C  YPIF L K  P+I    D K TI+   E + S         K   +   +V ++F F+YV E +   +     MSYPICM++IQ+    +  +L LN+G+ ++   L+K+ ++L ++  CL  G+ + +QM +A +V  +Y+A  SN+ S SAFPFI+G++SK   PN Q  LF GL + E   G ++K + I  Y+ T   +   VYL+LT F+ +A +L L      L    KLK E 
Sbjct:    2 YVYYRVGKDLNLTTNGNLAYVCNRNVTGGSEKEKTDKLQEIYTYNTMFIQLSSSIFTILTAPFYSVFSDRFGRKLMFILPGGGAFVKSVIEILIIVYEWPLYIFVITEGFYGLFGGFNFATSLSYSYIADISTQKERTKRMGIMGVLMGLGALLVSLVSGIWIKYRNYKEPYIFTGVVALLCFLYPIFLL-KEPPKIN---DPKKTIISPIEQMKSIVKVYWDKPKEYRALLILVFVLFNFYYVSEMSGLSLSGTYLMSYPICMDTIQLSIFGASNMLALNLGIGITIIFLSKFFSDLFLVFFCLLSGIAYLLQMAFAVSVTQVYLAAASNLFSFSAFPFIRGFMSKRMGPNEQGALFGGLALSETVCGAITKVITIYFYRETFRIFHGMVYLLLTGFSVIACVLILF----ALPIDRKLKAEE 417

[Close]

BLAST of slc46a-4 vs. Planmine SMEST
Match: SMESG000080390.1 (SMESG000080390.1)

HSP 1 Score: 89.3521 bits (220), Expect = 1.261e-18
Identity = 129/463 (27.86%), Postives = 209/463 (45.14%), Query Frame = 1

Query:  325 ETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFIYHKVKLCLDFFENEVSGNAC---NYSQ--SNATEKYQSDKVQYLSLNYVMGISLGFSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLDAFIYIETLHGLTG--GAMILYSVCFSLLANASKVENRNLRIVCGVIASALGAAIGSVSTGYMIKTYGFLPPFIVATII-SVGCVSYPIFCLEKSKPEIEEK---LDLKPTILEFSEIIFSAKN-----ILSSFTVVLLMFGFFYVGETAASEILYYIFMSYPICMNSIQIGYSISLEILVLNIGLILSGTILNKY--LNELVVI----LICLSFGLLFNIQMIYAKTV-KSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFML 1644
            E +     T +S  S+      +   M L  I +L + ++M Q+IY+++    D   NE S + C   N+S   SN   + QS   QY   N    +S G  I  +    F  +++  +GR+++I+ S IG FI ++   LLI  N  L  +I  + L GL G  GAM++    FSL+++++   NRN  I+   IA  L         G  ++   FL P +   II S+  V Y      ++K     +     +K TI +  E+ ++ K      I S+ +  +  F FF       + I  Y+F   P C NS  +GY  S+   ++  G+ILS  +L KY  +NE+++I    L  +   LLF I   YAK++   + I  G ++ S ++   ++   SK  +P     LF  ++  E     L   V   +Y  TL  Y   VY        +AF+L
Sbjct:    3 EDNIKDNKTMMSSKSYAV----IGLFMVLCYIGNLGQYTIMGQYIYYRISSDEDLVRNE-SVSQCSKVNFSSNFSNTQNRVQSSAAQY---NIYAQLSSG--IPSMIVVIFSGVLSDFYGRKLVILISWIGSFIGTIFNILLISLNGPLWVYIVGQFLSGLGGNYGAMLV--GVFSLVSDSTGHRNRNFGIIIIEIALGLSMITSQALLGKWLRLNNFLWPIVTFGIIFSLSGVMYLFLKETRNKRMTGNRNIQFHMKMTISKMIELFYNNKKFNFLLIFSTISFFIHTFNFF----GNMTLITVYLF-GRPFCWNSEILGYYRSISSAIVQFGIILSFLML-KYMRMNEILIIEVGFLTNILSKLLFAIAPSYAKSICDYLIIIAGFDLFSGASVSLLRSVSSKHVSPEDYGTLFGMMSSFETLSSLLGGVVYNGIYDATLSFYYGFVYCFAVVLLSIAFVL 447

[Close]

BLAST of slc46a-4 vs. Planmine SMEST
Match: SMESG000065078.1 (SMESG000065078.1)

HSP 1 Score: 65.0846 bits (157), Expect = 3.500e-12
Identity = 40/99 (40.40%), Postives = 55/99 (55.56%), Query Frame = 1

Query: 1405 IAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIGLTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIGISTLNHHLKLKIEH 1701
            +A  SN+ S SAFPFI+G++SK   PN Q  LF GL + E   G ++K + I  Y+ T   +   VYL+LT F+ +A +L L      L    KLK E 
Sbjct:   62 MAAASNLFSFSAFPFIRGFMSKRMGPNEQGALFGGLALSETVCGAITKVITIYFYRETFRIFHGMVYLLLTGFSVIACVLILF----ALPIDRKLKAEE 156

The following BLAST results are available for this feature:

BLAST of slc46a-4 vs. Ensembl Human
BLAST of slc46a-4 vs. Ensembl Celegans
BLAST of slc46a-4 vs. Ensembl Fly
BLAST of slc46a-4 vs. Ensembl Zebrafish
BLAST of slc46a-4 vs. Ensembl Xenopus
BLAST of slc46a-4 vs. Ensembl Mouse
BLAST of slc46a-4 vs. UniProt/SwissProt
BLAST of slc46a-4 vs. TrEMBL
BLAST of slc46a-4 vs. Ensembl Cavefish
BLAST of slc46a-4 vs. Ensembl Sea Lamprey
BLAST of slc46a-4 vs. Ensembl Yeast
BLAST of slc46a-4 vs. Ensembl Nematostella
BLAST of slc46a-4 vs. Ensembl Medaka
BLAST of slc46a-4 vs. Planmine SMEST

BLAST of slc46a-4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
SLC46A1	9.252e-8	21.81	solute carrier family 46 member 1 [Source:HGNC Sym...	[more]
SLC46A1	9.408e-6	21.38	solute carrier family 46 member 1 [Source:HGNC Sym...	[more]

BLAST of slc46a-4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of slc46a-4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of slc46a-4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
SLC46A3	5.723e-10	21.79	si:dkey-5g14.1 [Source:ZFIN;Acc:ZDB-GENE-091204-36...	[more]
SLC46A3	6.920e-10	21.79	si:dkey-5g14.1 [Source:ZFIN;Acc:ZDB-GENE-091204-36...	[more]
SLC46A3	6.920e-10	21.79	si:dkey-5g14.1 [Source:ZFIN;Acc:ZDB-GENE-091204-36...	[more]
slc46a3	7.341e-8	20.56	solute carrier family 46 member 3 [Source:ZFIN;Acc...	[more]

BLAST of slc46a-4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
slc46a1	6.174e-13	21.56	solute carrier family 46 (folate transporter), mem...	[more]
SLC46A3	3.293e-9	19.90	solute carrier family 46 member 3 [Source:NCBI gen...	[more]

BLAST of slc46a-4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Slc46a1	1.255e-9	22.15	solute carrier family 46, member 1 [Source:MGI Sym...	[more]
Slc46a2	4.082e-9	21.41	solute carrier family 46, member 2 [Source:MGI Sym...	[more]

BLAST of slc46a-4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6DCX5\|PCFT_XENLA	1.757e-13	22.46	Proton-coupled folate transporter OS=Xenopus laevi...	[more]
sp\|Q5F4B8\|S46A3_CHICK	2.417e-12	22.10	Solute carrier family 46 member 3 OS=Gallus gallus...	[more]
sp\|Q5EBA8\|PCFT_RAT	5.304e-10	22.69	Proton-coupled folate transporter OS=Rattus norveg...	[more]
sp\|Q6PEM8\|PCFT_MOUSE	8.775e-9	22.15	Proton-coupled folate transporter OS=Mus musculus ...	[more]
sp\|Q8CA03\|TSCOT_MOUSE	2.855e-8	21.41	Thymic stromal cotransporter protein OS=Mus muscul...	[more]

BLAST of slc46a-4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0H3YJH7	0.000e+0	100.00	Slc46a-4 OS=Schmidtea mediterranea OX=79327 GN=slc...	[more]
A0A0H3YFD5	6.949e-92	39.40	Slc46a-3 OS=Schmidtea mediterranea OX=79327 GN=slc...	[more]
A0A0H3YJM6	2.619e-66	34.22	Slc46a-2 OS=Schmidtea mediterranea OX=79327 GN=slc...	[more]
A0A401SAI9	3.399e-18	22.75	MFS domain-containing protein OS=Chiloscyllium pun...	[more]
V3ZU71	5.319e-18	24.94	Uncharacterized protein (Fragment) OS=Lottia gigan...	[more]

BLAST of slc46a-4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
si:dkey-5g14.1	1.105e-8	20.64	solute carrier family 46 member 3-like [Source:NCB...	[more]
slc46a3	1.133e-7	21.09	solute carrier family 46 member 3 [Source:ZFIN;Acc...	[more]
slc46a3	1.133e-7	21.09	solute carrier family 46 member 3 [Source:ZFIN;Acc...	[more]
si:ch211-262i1.4	5.963e-6	25.95	si:ch211-262i1.4 [Source:ZFIN;Acc:ZDB-GENE-140106-...	[more]

BLAST of slc46a-4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
slc46a3	1.299e-14	21.88	solute carrier family 46 member 3 [Source:ZFIN;Acc...	[more]

BLAST of slc46a-4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of slc46a-4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO38916	9.234e-12	21.77	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42708	1.903e-9	18.18	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32892	3.117e-9	20.36	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48562	3.885e-7	19.72	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO27580	5.607e-7	24.55	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of slc46a-4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
si:dkey-5g14.1	1.082e-11	24.73	solute carrier family 46 member 3 [Source:NCBI gen...	[more]
si:dkey-5g14.1	1.082e-11	24.73	solute carrier family 46 member 3 [Source:NCBI gen...	[more]
si:dkey-5g14.1	4.094e-11	24.42	solute carrier family 46 member 3 [Source:HGNC Sym...	[more]

BLAST of slc46a-4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000065066.1	0.000e+0	99.14	SMESG000065066.1	[more]
SMESG000065064.1	7.102e-95	39.40	SMESG000065064.1	[more]
SMESG000065078.1	5.630e-64	33.49	SMESG000065078.1	[more]
SMESG000080390.1	1.261e-18	27.86	SMESG000080390.1	[more]
SMESG000065078.1	3.500e-12	40.40	SMESG000065078.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30033628
GenBank	AKN21696.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033628 ID=SMED30033628|Name=slc46a-4|organism=Schmidtea mediterranea sexual|type=transcript|length=1791bp
ATTTTCTTTCATCTATTCCATTGTAATTTTAATATAAATATTTAGTTGTA
GTGACAAACTGTGAAGAATTATATCCGTAAGCATCTGGTAACATCTGAAT
GAACTATTTATTTATTTCATTCGTAATCTCTTGAAAAGTGTCCGTCTATT
AACATAACATACAAGTTTGACGAACCAGATAGTGAATCGAAAGACAAATC
ACGTTGCGAGAGCGAATTATTCGAGAAAAGTTTCTACGAGTGTTCATTAT
AGACTTTATTCACATCGTTCCGCTTGAATTGTAATTACATCTTTTACGGC
ATTGTTGCAATGAATATTGAGGCCGAAACCGACTGCTTGTTGCGCCCAAC
CCAATTGTCCAAACCATCATTTTGTCGGAAAATATTCGGAGTTGAATTTT
TAATGTTCTTATATGGAATAATCGACTTGACTGAATCTAGCGTAATGAAA
CAATTTATTTATCACAAAGTCAAACTTTGTTTAGATTTTTTCGAAAATGA
AGTCTCAGGCAACGCTTGCAATTATAGTCAGTCAAATGCCACAGAAAAAT
ATCAAAGTGATAAAGTTCAATACCTTTCCTTAAATTATGTAATGGGGATA
AGTTTGGGGTTTTCTATTGCCGTTTTATTTACGTCTCCATTTCATTTAAT
TGTGGCGAGACGATTCGGTCGGAGGATTTTGATAATTTATTCTGGAATAG
GATTTTTTATCAAATCAGTCTGTGAGTGCTTACTAATATTTCGGAACTGG
TCTTTGGATGCATTCATTTACATTGAAACTTTGCATGGATTAACTGGGGG
AGCCATGATTCTTTATAGCGTTTGCTTTAGTTTATTAGCTAATGCGTCGA
AAGTAGAAAACAGAAATCTTCGAATTGTTTGTGGAGTCATTGCCAGTGCT
CTTGGCGCTGCAATAGGGTCAGTCTCCACGGGTTACATGATCAAAACGTA
TGGTTTTCTTCCTCCATTCATTGTGGCAACAATTATTTCGGTGGGATGTG
TTTCCTACCCGATATTTTGTCTTGAGAAATCAAAACCTGAAATTGAAGAA
AAATTAGATTTGAAACCAACGATCTTGGAATTTTCTGAAATTATTTTCTC
AGCGAAAAACATTTTGTCGAGTTTTACAGTGGTGCTTTTGATGTTTGGGT
TCTTCTATGTCGGAGAAACTGCTGCCAGTGAAATTTTATATTATATTTTC
ATGTCTTACCCGATATGCATGAATTCTATACAGATTGGATACAGTATTTC
TTTGGAAATTTTGGTTTTGAATATAGGACTGATACTTTCTGGAACCATTC
TAAATAAATATTTGAATGAACTTGTCGTTATCTTGATATGCCTAAGTTTC
GGTCTCTTATTCAATATCCAGATGATCTATGCTAAAACAGTTAAATCAAT
TTATATTGCTTTCGGGTCGAATGTTTTATCATCAAGTGCTTTTCCATTCA
TCAAAGGATACCTTTCCAAGCTGACAGCACCAAATCTTCAAACTTACCTA
TTCATTGGGTTGACTGTACTAGAAGTTTTTCTAGGGTGTTTATCAAAGTC
AGTAGTGATCATTTTATACCAAAGAACCTTGGAAGACTACCAAGAAACGG
TTTATTTAATTTTAACATGTTTCACTGGAGTCGCTTTCATGTTATCACTA
TTAATAGGAATTTCGACCCTAAATCACCATTTGAAGCTAAAGATTGAACA
TCAAGAAACATAATCAAATTCAGATGTTTGGTTTAAAGATTTCTCAGAAA
TAATTTTTTTATAAATAAATTTGATATACACTTTAGTTAAC

protein sequence of SMED30033628-orf-1

>SMED30033628-orf-1 ID=SMED30033628-orf-1|Name=SMED30033628-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=468bp
MNIEAETDCLLRPTQLSKPSFCRKIFGVEFLMFLYGIIDLTESSVMKQFI
YHKVKLCLDFFENEVSGNACNYSQSNATEKYQSDKVQYLSLNYVMGISLG
FSIAVLFTSPFHLIVARRFGRRILIIYSGIGFFIKSVCECLLIFRNWSLD
AFIYIETLHGLTGGAMILYSVCFSLLANASKVENRNLRIVCGVIASALGA
AIGSVSTGYMIKTYGFLPPFIVATIISVGCVSYPIFCLEKSKPEIEEKLD
LKPTILEFSEIIFSAKNILSSFTVVLLMFGFFYVGETAASEILYYIFMSY
PICMNSIQIGYSISLEILVLNIGLILSGTILNKYLNELVVILICLSFGLL
FNIQMIYAKTVKSIYIAFGSNVLSSSAFPFIKGYLSKLTAPNLQTYLFIG
LTVLEVFLGCLSKSVVIILYQRTLEDYQETVYLILTCFTGVAFMLSLLIG
ISTLNHHLKLKIEHQET*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0022857	transmembrane transporter activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036259	MFS_trans_sf
IPR011701	MFS
IPR020846	MFS_dom

Vocabulary: **cellular component**
Term	Definition
GO:0016021	integral component of membrane
GO:0016020	membrane

Vocabulary: **biological process**
Term	Definition
GO:0055085	transmembrane transport

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR011701	Major facilitator superfamily	PFAM	PF07690	MFS_1	coord: 95..392 e-value: 3.2E-14 score: 52.6
None	No IPR available	GENE3D	G3DSA:1.20.1250.20		coord: 81..450 e-value: 4.7E-19 score: 70.4
None	No IPR available	PANTHER	PTHR23507	FAMILY NOT NAMED	coord: 23..452
None	No IPR available	CDD	cd17386	MFS_SLC46	coord: 98..449 e-value: 1.77446E-18 score: 84.6367
None	No IPR available	TMHMM	TMhelix		coord: 363..385
None	No IPR available	TMHMM	TMhelix		coord: 94..116
None	No IPR available	TMHMM	TMhelix		coord: 430..452
None	No IPR available	TMHMM	TMhelix		coord: 398..420
None	No IPR available	TMHMM	TMhelix		coord: 338..358
None	No IPR available	TMHMM	TMhelix		coord: 155..177
None	No IPR available	TMHMM	TMhelix		coord: 123..145
None	No IPR available	TMHMM	TMhelix		coord: 272..294
None	No IPR available	TMHMM	TMhelix		coord: 216..238
None	No IPR available	TMHMM	TMhelix		coord: 309..331
None	No IPR available	TMHMM	TMhelix		coord: 189..211
None	No IPR available	TMHMM	TMhelix		coord: 21..38
IPR036259	MFS transporter superfamily	SUPERFAMILY	SSF103473	MFS general substrate transporter	coord: 89..457

Main menu

slc46a-4

Zeng et. al., 2018

▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Owlery

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