Tetraspanin
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033611 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Tetraspanin vs. Ensembl Fly
Match: Tsp66E (gene:FBgn0035936 transcript:FBtr0076507) HSP 1 Score: 50.447 bits (119), Expect = 1.228e-6 Identity = 28/75 (37.33%), Postives = 40/75 (53.33%), Query Frame = 3 Query: 741 IQAKFKCCGADNSTDFISNP--TSNKNYGVIPYSCCILNDPSFQVTY-SNCTANPSTTNSNMATGCYDKL--WVI 950 + F CCG ++ DF ++P + K IP +CCIL D + V +CT NPS +NS GCY+ W+I Sbjct: 155 LMGNFGCCGINDYHDFDASPAWVNGKGNRTIPDACCILKDVAKLVPRDEDCTTNPSDSNSFYKKGCYEVFTEWLI 229
BLAST of Tetraspanin vs. Ensembl Fly
Match: Tsp66E (gene:FBgn0035936 transcript:FBtr0076506) HSP 1 Score: 50.447 bits (119), Expect = 1.228e-6 Identity = 28/75 (37.33%), Postives = 40/75 (53.33%), Query Frame = 3 Query: 741 IQAKFKCCGADNSTDFISNP--TSNKNYGVIPYSCCILNDPSFQVTY-SNCTANPSTTNSNMATGCYDKL--WVI 950 + F CCG ++ DF ++P + K IP +CCIL D + V +CT NPS +NS GCY+ W+I Sbjct: 155 LMGNFGCCGINDYHDFDASPAWVNGKGNRTIPDACCILKDVAKLVPRDEDCTTNPSDSNSFYKKGCYEVFTEWLI 229
BLAST of Tetraspanin vs. Ensembl Fly
Match: Tsp66E (gene:FBgn0035936 transcript:FBtr0076508) HSP 1 Score: 50.447 bits (119), Expect = 1.228e-6 Identity = 28/75 (37.33%), Postives = 40/75 (53.33%), Query Frame = 3 Query: 741 IQAKFKCCGADNSTDFISNP--TSNKNYGVIPYSCCILNDPSFQVTY-SNCTANPSTTNSNMATGCYDKL--WVI 950 + F CCG ++ DF ++P + K IP +CCIL D + V +CT NPS +NS GCY+ W+I Sbjct: 155 LMGNFGCCGINDYHDFDASPAWVNGKGNRTIPDACCILKDVAKLVPRDEDCTTNPSDSNSFYKKGCYEVFTEWLI 229
BLAST of Tetraspanin vs. Ensembl Xenopus
Match: fam110d (family with sequence similarity 110 member D [Source:Xenbase;Acc:XB-GENE-920630]) HSP 1 Score: 48.521 bits (114), Expect = 8.619e-6 Identity = 25/80 (31.25%), Postives = 41/80 (51.25%), Query Frame = 3 Query: 732 IDVIQAKFKCCGADNSTDFISNPTSNKNYGVIPYSCCILNDPSFQVTYSNCTANPSTTNSNMATGCYDKLWVILNSYSTY 971 ++ IQ + +CCG N TD+ + +N+ IP +CC TY+ C N + + + GC+DKL LN + T+ Sbjct: 134 VNKIQKELRCCGLHNYTDWEATSWYRQNF-TIPKTCC-------NETYTTCYGNTTESKAFYQEGCFDKLHHRLNYFMTW 205
BLAST of Tetraspanin vs. TrEMBL
Match: A0A267GPF0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig019757g1 PE=3 SV=1) HSP 1 Score: 84.3445 bits (207), Expect = 1.940e-14 Identity = 80/264 (30.30%), Postives = 131/264 (49.62%), Query Frame = 3 Query: 228 DIGKCXXXXXXXXXXXXASALIVIGALLQWGSESVKSTIIPGISKLAAPN---STTISMTDLSKILSDYVAVLGNAXXXXXXXXXXXXXXXXXXXXXXXXXXRLLMXXXXXXXXXXXXXXXXXXXXXXXKRTDLQTSAKYFYKSFLKDKYVFXXXXXXXXXXXXXXDPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNYG---------VIPYSCCILNDPSFQVTYSNCTANPSTTNSNM-ATGCYDKLWVILNSYSTYAAY 980 + KC+L +N + + + L +IG +L WG V + +S + + ST +S +DL K+L + + AG+ + +G+ L I G G CC+S+LL+I+Y+V+ + + + + + ++T + +K +Y S + T I+D+IQA+ CCG DN T + T N Y V+P SCC ++ +F+ TY NCT +P + NSNM GCY KLW ++YS YA Y Sbjct: 17 QVAKCVLGAINGILITIGVVLAIIGCILHWGGNLVFQLLSAALSNIGSSQIGSSTPLSFSDLQKVLGTWSVYVSYAGIALLAVGLFLVATGIIGAIGACCNSKLLIIVYIVIMAVLALACAGLAAGYIINKNLMRTEGAKQMTTLVKSEY---------KGRGSANEFTNILDLIQARVPCCGVDNYTIYHEFNTWNSTYQLKNGTYIDEVLPESCCKISGATFEPTYENCTYSPDSQNSNMYEGGCYTKLWNAFDTYSAYATY 271
BLAST of Tetraspanin vs. TrEMBL
Match: A0A1I8G566 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 80.1073 bits (196), Expect = 2.287e-12 Identity = 75/240 (31.25%), Postives = 122/240 (50.83%), Query Frame = 3 Query: 288 LIVIGALLQWGSESVKSTIIPGISKLAAPNSTTISMTDLSKILSDYVAVLGNAXXXXXXXXXXXXXXXXXXXXXXXXXXRLLMXXXXXXXXXXXXXXXXXXXXXXXKRTDLQTSAKYFYKSFLKDKYVFXXXXXXXXXXXXXXDPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNY--------GVIPYSCCILNDPSFQVTYSNCTANPSTTNSN-MATGCYDKLWVILNSYSTYAAY 980 L + GAL WG ++V + I ++K ++ IS+ ++ +L + L AG+I+F +GI L + I G G+CC ++L+I Y V V + +I + V + D+ + L+ +Y + S + + T I+D+IQA+ CCG DN TDF ++ N+ Y P SCC++ PS + Y C + P++ NSN M GCY KLW + ++YS Y Y Sbjct: 30 LTIFGALFYWGQQAVYNWISSMLAKSDVGSTRQISLEEIQAVLGAWSRYLTYAGVILFGLGIALVGLAIIGYIGMCCEFKVLVIAYTVTVGAFGVGCIGVVISYGVFKKDMVHFGRTEMLKLLRQRY---------NNSGTPNEFTTILDLIQARMPCCGVDNYTDFYNSTGWNRTYIQDKVEYNLTAPISCCMITGPSMRPDYPECVSAPNSNNSNYMVGGCYGKLWAMFDNYSAYTMY 260 HSP 2 Score: 78.1814 bits (191), Expect = 1.153e-11 Identity = 37/93 (39.78%), Postives = 54/93 (58.06%), Query Frame = 3 Query: 717 DPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNY------GVI----PYSCCILNDPSFQVTYSNCTANPSTTNSNMATGCYDKLWVILNSYS 965 D + I+D++Q + CCG N T+F S N+ Y G I P +CC L F+ ++NCT +P+ NSN+ TGCYDKLW L++Y+ Sbjct: 415 DFSKILDIVQGQLDCCGVTNYTEFYSAGQWNRTYYYSDSVGYIQLTAPIACCKLRKSDFEPQFANCTLSPTAQNSNIHTGCYDKLWEFLDTYA 507
BLAST of Tetraspanin vs. TrEMBL
Match: A0A267FF84 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006986g1 PE=3 SV=1) HSP 1 Score: 78.1814 bits (191), Expect = 2.490e-12 Identity = 37/93 (39.78%), Postives = 54/93 (58.06%), Query Frame = 3 Query: 717 DPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNY------GVI----PYSCCILNDPSFQVTYSNCTANPSTTNSNMATGCYDKLWVILNSYS 965 D + I+D++Q + CCG N T+F S N+ Y G I P +CC L F+ ++NCT +P+ NSN+ TGCYDKLW L++Y+ Sbjct: 170 DFSKILDIVQGQLDCCGVTNYTEFYSAGQWNRTYYYSDSVGYIQLTAPIACCKLRKSDFEPQFANCTLSPTAQNSNIHTGCYDKLWEFLDTYA 262
BLAST of Tetraspanin vs. TrEMBL
Match: A0A1I8J561 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 79.7221 bits (195), Expect = 3.451e-12 Identity = 75/240 (31.25%), Postives = 121/240 (50.42%), Query Frame = 3 Query: 288 LIVIGALLQWGSESVKSTIIPGISKLAAPNSTTISMTDLSKILSDYVAVLGNAXXXXXXXXXXXXXXXXXXXXXXXXXXRLLMXXXXXXXXXXXXXXXXXXXXXXXKRTDLQTSAKYFYKSFLKDKYVFXXXXXXXXXXXXXXDPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNY--------GVIPYSCCILNDPSFQVTYSNCTANPSTTNSN-MATGCYDKLWVILNSYSTYAAY 980 L + GAL WG ++V + I ++K ++ IS+ ++ +L + L AG+I+F +GI L + I G G+CC ++L+I Y V V + +I + V + D+ + L+ +Y + S + + T I+D+IQA+ CCG DN TDF + N+ Y P SCC++ PS + Y C + P++ NSN M GCY KLW + ++YS Y Y Sbjct: 30 LTIFGALFYWGQQAVYNWISSMLAKSDVGSTRQISLEEIQAVLGAWSRYLTYAGVILFGLGIALVGLAIIGYIGMCCEFKVLVIAYTVTVGAFGVGCIGVVISYGVFKKDMVHFGRTEMLKLLRQRY---------NNSGTPNEFTTILDLIQARMPCCGVDNYTDFYNATGWNRTYIQDKVEYNLTAPISCCMITGPSMRPDYPECVSAPNSNNSNYMVGGCYGKLWAMFDNYSAYTMY 260 HSP 2 Score: 75.485 bits (184), Expect = 7.309e-11 Identity = 36/93 (38.71%), Postives = 53/93 (56.99%), Query Frame = 3 Query: 717 DPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNY------GVI----PYSCCILNDPSFQVTYSNCTANPSTTNSNMATGCYDKLWVILNSYS 965 D + I+D++Q + CCG N T+F S N+ Y G I P +CC L F+ ++NCT +P+ NSN+ T CYDKLW L++Y+ Sbjct: 415 DFSKILDIVQGQLDCCGVTNYTEFYSAGQWNRTYYYSDSVGYIQLTAPIACCKLRKSDFEPQFANCTLSPTAQNSNIHTACYDKLWEFLDTYA 507
BLAST of Tetraspanin vs. TrEMBL
Match: A0A1I8IT22 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 75.0998 bits (183), Expect = 1.009e-11 Identity = 38/93 (40.86%), Postives = 52/93 (55.91%), Query Frame = 3 Query: 717 DPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNYG----------VIPYSCCILNDPSFQVTYSNCTANPSTTNSNMATGCYDKLWVILNSYS 965 D + ++D+IQ + +CCG DN TDF S N+ Y V P SCC L+ +F+ NCT NP+ +NSN CY KLW IL +Y+ Sbjct: 99 DFSKVLDIIQGRLECCGIDNFTDFYSASQWNRTYYLSSESRYVTLVAPLSCCQLSMTTFEPVDKNCTYNPTPSNSNYMKSCYGKLWDILTTYA 191
BLAST of Tetraspanin vs. Planmine SMEST
Match: SMESG000049184.1 (SMESG000049184.1) HSP 1 Score: 332.028 bits (850), Expect = 2.355e-112 Identity = 275/281 (97.86%), Postives = 277/281 (98.58%), Query Frame = 3 Query: 219 MCKDIGKCXXXXXXXXXXXXASALIVIGALLQWGSESVKSTIIPGISKLAAPNSTTISMTDLSKILSDYVAVLGNAXXXXXXXXXXXXXXXXXXXXXXXXXXRLLMXXXXXXXXXXXXXXXXXXXXXXXKRTDLQTSAKYFYKSFLKDKYVFXXXXXXXXXXXXXXDPTGIIDVIQAKFKCCGADNSTDFISNPTSNKNYGVIPYSCCILNDPSFQVTYSNCTANPSTTNSNMATGCYDKLWVILNSYSTYAAYXXXXXXXXXXXXXXXXXXXQKSYRDKE 1061 MCKDIGKCILIIVNILFLLVASALIVIGALLQWGS++VKSTIIPGISKLAAPNS TISMTDLSKILSDYVAVLGNAGLIIFIIGIILFVICICGTCGVCCSSRLLMIIYLVLTLTIWVLIVIFIIVFFVKRTDLQTSAK FYKSFLKDKYVFNNGSNALSASSSGLDPTGIIDVIQAKFKCCGADNSTDFISNPT NKNYGVIPYSCCILNDPSFQVTYSNCT NPSTTNSNMATGCYDKLWVILNSYSTYAAYGLVGLGIILLILIIIAGVLQKSYRDKE Sbjct: 1 MCKDIGKCILIIVNILFLLVASALIVIGALLQWGSDTVKSTIIPGISKLAAPNSATISMTDLSKILSDYVAVLGNAGLIIFIIGIILFVICICGTCGVCCSSRLLMIIYLVLTLTIWVLIVIFIIVFFVKRTDLQTSAKDFYKSFLKDKYVFNNGSNALSASSSGLDPTGIIDVIQAKFKCCGADNSTDFISNPTYNKNYGVIPYSCCILNDPSFQVTYSNCTTNPSTTNSNMATGCYDKLWVILNSYSTYAAYGLVGLGIILLILIIIAGVLQKSYRDKE 281 The following BLAST results are available for this feature:
BLAST of Tetraspanin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 3
BLAST of Tetraspanin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Tetraspanin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Tetraspanin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Tetraspanin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tetraspanin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Tetraspanin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033611 ID=SMED30033611|Name=Tetraspanin|organism=Schmidtea mediterranea sexual|type=transcript|length=1323bpback to top protein sequence of SMED30033611-orf-1 >SMED30033611-orf-1 ID=SMED30033611-orf-1|Name=SMED30033611-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=282bp MCKDIGKCILIIVNILFLLVASALIVIGALLQWGSESVKSTIIPGISKLAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|