IQ motif and Sec7 domain-1

Overview


Name	IQ motif and Sec7 domain-1 (AFJ24772.1)
Smed ID	SMED30033566
Length (bp)	2940

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of IQ motif and Sec7 domain-1 (SMED30033566) t-SNE clustered cells

Violin plots show distribution of expression levels for IQ motif and Sec7 domain-1 (SMED30033566) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of IQ motif and Sec7 domain-1 (SMED30033566) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for IQ motif and Sec7 domain-1 (SMED30033566) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033566

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
posterior side	SMED30033566	h1SMcG0011066	dd_Smed_v4_7415_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30033566	h1SMcG0011066	dd_Smed_v4_7415_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30033566	h1SMcG0011066	dd_Smed_v6_7415_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Symbol;Acc:HGNC:29112])

HSP 1 Score: 308.145 bits (788), Expect = 1.588e-90
Identity = 169/364 (46.43%), Postives = 231/364 (63.46%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRPR---NLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KGV YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G      L P     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  397 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 758

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Symbol;Acc:HGNC:29112])

HSP 1 Score: 307.76 bits (787), Expect = 2.067e-90
Identity = 169/364 (46.43%), Postives = 231/364 (63.46%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRPR---NLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KGV YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G      L P     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  397 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 758

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Symbol;Acc:HGNC:29112])

HSP 1 Score: 310.842 bits (795), Expect = 2.481e-90
Identity = 169/364 (46.43%), Postives = 231/364 (63.46%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRPR---NLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KGV YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G      L P     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  519 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 880

HSP 2 Score: 57.3806 bits (137), Expect = 1.446e-7
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S+++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   80 RRPKLQHSTSILRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 172

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Symbol;Acc:HGNC:29112])

HSP 1 Score: 310.842 bits (795), Expect = 2.901e-90
Identity = 169/364 (46.43%), Postives = 231/364 (63.46%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRPR---NLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KGV YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G      L P     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  520 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 881

HSP 2 Score: 57.3806 bits (137), Expect = 1.351e-7
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S+++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   81 RRPKLQHSTSILRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 173

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Symbol;Acc:HGNC:29112])

HSP 1 Score: 311.612 bits (797), Expect = 1.408e-89
Identity = 168/358 (46.93%), Postives = 228/358 (63.69%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRPR---NLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KGV YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G      L P     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  511 KRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 866

HSP 2 Score: 57.7658 bits (138), Expect = 1.198e-7
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S+++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   66 RRPKLQHSTSILRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 158

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
Match: bris-1 (BRag/Iqsec/Schizo related Arf GEF family member [Source:UniProtKB/TrEMBL;Acc:U4PLL0])

HSP 1 Score: 251.521 bits (641), Expect = 2.036e-73
Identity = 134/363 (36.91%), Postives = 213/363 (58.68%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVD------DGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD--GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSP 2261
            ++  KR YRI LN FNK   +GV  L  + FV+ SP+ LA  L  R+G+S+  IG+Y+G       +  LK+F  ++D+R  E+D+ALR  + FF +P E++KI  I++ F   Y + N +         DTI +L++AIIML+TD+++PN+++  +M++ +F+ NLR  D      +G+DI+   L  IYDRIK  E+K   DH  QV+++D+   G  +PR L +  RRLVCYCRL +V D  K+    A +R+VFLFND++V+ KGV++      G  Y  +    L    +  F+   Y FG+ +   ++    FN R   DR  FV D+ E++ E +EM+++R+E E+ +   + + P
Sbjct:   78 DQERKRQYRIALNFFNKKPERGVQLLTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLSFAIIMLNTDLHSPNVKQ--RMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDDHVAQVQRVDRAIVGKDKPR-LTETPRRLVCYCRLQQVSDPTKRQSSSARERDVFLFNDMIVVAKGVRRGSTSMAGCTYTLKQWTLLLGAHVTEFQRGQYEFGLTITCPNKDKIHFNARNFEDRCHFVADVTESIREATEMEQVRLEMEMEQHTTTTIRP 437

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
Match: bris-1 (BRag/Iqsec/Schizo related Arf GEF family member [Source:UniProtKB/TrEMBL;Acc:U4PLL0])

HSP 1 Score: 251.136 bits (640), Expect = 2.801e-73
Identity = 134/363 (36.91%), Postives = 213/363 (58.68%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVD------DGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD--GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSP 2261
            ++  KR YRI LN FNK   +GV  L  + FV+ SP+ LA  L  R+G+S+  IG+Y+G       +  LK+F  ++D+R  E+D+ALR  + FF +P E++KI  I++ F   Y + N +         DTI +L++AIIML+TD+++PN+++  +M++ +F+ NLR  D      +G+DI+   L  IYDRIK  E+K   DH  QV+++D+   G  +PR L +  RRLVCYCRL +V D  K+    A +R+VFLFND++V+ KGV++      G  Y  +    L    +  F+   Y FG+ +   ++    FN R   DR  FV D+ E++ E +EM+++R+E E+ +   + + P
Sbjct:   83 DQERKRQYRIALNFFNKKPERGVQLLTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLSFAIIMLNTDLHSPNVKQ--RMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDDHVAQVQRVDRAIVGKDKPR-LTETPRRLVCYCRLQQVSDPTKRQSSSARERDVFLFNDMIVVAKGVRRGSTSMAGCTYTLKQWTLLLGAHVTEFQRGQYEFGLTITCPNKDKIHFNARNFEDRCHFVADVTESIREATEMEQVRLEMEMEQHTTTTIRP 442

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
Match: bris-1 (BRag/Iqsec/Schizo related Arf GEF family member [Source:UniProtKB/TrEMBL;Acc:U4PLL0])

HSP 1 Score: 251.136 bits (640), Expect = 1.158e-72
Identity = 134/363 (36.91%), Postives = 213/363 (58.68%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVD------DGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD--GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSP 2261
            ++  KR YRI LN FNK   +GV  L  + FV+ SP+ LA  L  R+G+S+  IG+Y+G       +  LK+F  ++D+R  E+D+ALR  + FF +P E++KI  I++ F   Y + N +         DTI +L++AIIML+TD+++PN+++  +M++ +F+ NLR  D      +G+DI+   L  IYDRIK  E+K   DH  QV+++D+   G  +PR L +  RRLVCYCRL +V D  K+    A +R+VFLFND++V+ KGV++      G  Y  +    L    +  F+   Y FG+ +   ++    FN R   DR  FV D+ E++ E +EM+++R+E E+ +   + + P
Sbjct:  142 DQERKRQYRIALNFFNKKPERGVQLLTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLSFAIIMLNTDLHSPNVKQ--RMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDDHVAQVQRVDRAIVGKDKPR-LTETPRRLVCYCRLQQVSDPTKRQSSSARERDVFLFNDMIVVAKGVRRGSTSMAGCTYTLKQWTLLLGAHVTEFQRGQYEFGLTITCPNKDKIHFNARNFEDRCHFVADVTESIREATEMEQVRLEMEMEQHTTTTIRP 501

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
Match: bris-1 (BRag/Iqsec/Schizo related Arf GEF family member [Source:UniProtKB/TrEMBL;Acc:U4PLL0])

HSP 1 Score: 251.906 bits (642), Expect = 4.366e-72
Identity = 134/359 (37.33%), Postives = 211/359 (58.77%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVD------DGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD--GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSP 2261
            KR YRI LN FNK   +GV  L  + FV+ SP+ LA  L  R+G+S+  IG+Y+G       +  LK+F  ++D+R  E+D+ALR  + FF +P E++KI  I++ F   Y + N +         DTI +L++AIIML+TD+++PN+++  +M++ +F+ NLR  D      +G+DI+   L  IYDRIK  E+K   DH  QV+++D+   G  +PR L +  RRLVCYCRL +V D  K+    A +R+VFLFND++V+ KGV++      G  Y  +    L    +  F+   Y FG+ +   ++    FN R   DR  FV D+ E++ E +EM+++R+E E+ +   + + P
Sbjct:  225 KRQYRIALNFFNKKPERGVQLLTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLSFAIIMLNTDLHSPNVKQ--RMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDDHVAQVQRVDRAIVGKDKPR-LTETPRRLVCYCRLQQVSDPTKRQSSSARERDVFLFNDMIVVAKGVRRGSTSMAGCTYTLKQWTLLLGAHVTEFQRGQYEFGLTITCPNKDKIHFNARNFEDRCHFVADVTESIREATEMEQVRLEMEMEQHTTTTIRP 580

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
Match: gbf-1 (pep chromosome:WBcel235:III:11751320:11773681:-1 gene:WBGene00007703.1 transcript:C24H11.7a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:gbf-1)

HSP 1 Score: 104.76 bits (260), Expect = 2.294e-22
Identity = 62/210 (29.52%), Postives = 107/210 (50.95%), Query Frame = 3

Query: 1185 QAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNI-RKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRK 1811
            Q   +++ KRL      +FN++  KG+++L     +      L ++L +   + + +I DY+ + K     E L  FV+     N  +D+ALR  L  F++PGES +I  +M+ F E +   N + +  +    D    L+YAIIML+ D +NP   R Q  M+ + F  NL   +D +D +P +L  +Y  IKT E+   ++    V++
Sbjct:  624 QIIEQKKRKRLIAEGTELFNQSPKKGIAFLREKGILGHDEQSLVQWLRTNPQLDKKAIADYICNRKH---AEVLNAFVKSFPFENTRLDVALRMFLETFRLPGESAEIALVMQHFSEEWFRANNEPFFHV----DAAFTLSYAIIMLNVDQHNPQAKRSQPPMTVDCFRRNLSGTNDSRDFDPEMLADMYQAIKTEEIVMPAEQKGTVKE 826

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
Match: siz (gene:FBgn0026179 transcript:FBtr0111038)

HSP 1 Score: 333.954 bits (855), Expect = 2.586e-97
Identity = 169/360 (46.94%), Postives = 240/360 (66.67%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR--DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRS-NVSPG 2264
            +E   KR YR+ LN+FNK   KG++YLIR  F+E +P  +A+FL++RKG+SR  IG+YLG+ ++      L  F   +D+  +++D+ALR   ++F++PGE+QKI+ +ME F + Y E N     ++ ++ DTI +LA+AIIML+TD++ PN++ + +M  E+FI NLR +DD  DI+ ++L  IYDR+K+ E K  SDH  QV K+     G  +  NL  PHRRLVCYCRL+E+ D  KK+R G HQREVFLFNDLLVITK +  +KK  V Y  RN+  L    + L +   YPF IQL +  D +IL TFN R   DR +F EDL E++SE+ EM+ LRIE EL +Q+ + N +PG
Sbjct:  647 SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRL-RSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVG--KKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITK-IFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPG 1002

HSP 2 Score: 55.4546 bits (132), Expect = 2.884e-7
Identity = 28/63 (44.44%), Postives = 42/63 (66.67%), Query Frame = 3

Query:  219 SYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKL----KLEKRVSRRL 395
            +YELS+DL EK+IE  ER++GG  ++  AA  IQ ++R Y + K +  +    K EKR+SRR+
Sbjct:  197 AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRM 258

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
Match: siz (gene:FBgn0026179 transcript:FBtr0301602)

HSP 1 Score: 333.569 bits (854), Expect = 3.519e-97
Identity = 169/360 (46.94%), Postives = 240/360 (66.67%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR--DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRS-NVSPG 2264
            +E   KR YR+ LN+FNK   KG++YLIR  F+E +P  +A+FL++RKG+SR  IG+YLG+ ++      L  F   +D+  +++D+ALR   ++F++PGE+QKI+ +ME F + Y E N     ++ ++ DTI +LA+AIIML+TD++ PN++ + +M  E+FI NLR +DD  DI+ ++L  IYDR+K+ E K  SDH  QV K+     G  +  NL  PHRRLVCYCRL+E+ D  KK+R G HQREVFLFNDLLVITK +  +KK  V Y  RN+  L    + L +   YPF IQL +  D +IL TFN R   DR +F EDL E++SE+ EM+ LRIE EL +Q+ + N +PG
Sbjct:  657 SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRL-RSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVG--KKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITK-IFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPG 1012

HSP 2 Score: 55.0694 bits (131), Expect = 3.254e-7
Identity = 28/63 (44.44%), Postives = 42/63 (66.67%), Query Frame = 3

Query:  219 SYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKL----KLEKRVSRRL 395
            +YELS+DL EK+IE  ER++GG  ++  AA  IQ ++R Y + K +  +    K EKR+SRR+
Sbjct:  207 AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRM 268

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
Match: siz (gene:FBgn0026179 transcript:FBtr0078290)

HSP 1 Score: 333.569 bits (854), Expect = 9.706e-97
Identity = 168/355 (47.32%), Postives = 238/355 (67.04%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR--DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRS-NVSPG 2264
            KR YR+ LN+FNK   KG++YLIR  F+E +P  +A+FL++RKG+SR  IG+YLG+ ++      L  F   +D+  +++D+ALR   ++F++PGE+QKI+ +ME F + Y E N     ++ ++ DTI +LA+AIIML+TD++ PN++ + +M  E+FI NLR +DD  DI+ ++L  IYDR+K+ E K  SDH  QV K+     G  +  NL  PHRRLVCYCRL+E+ D  KK+R G HQREVFLFNDLLVITK +  +KK  V Y  RN+  L    + L +   YPF IQL +  D +IL TFN R   DR +F EDL E++SE+ EM+ LRIE EL +Q+ + N +PG
Sbjct:  755 KRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRL-RSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVG--KKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITK-IFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPG 1105

HSP 2 Score: 55.4546 bits (132), Expect = 3.087e-7
Identity = 28/63 (44.44%), Postives = 42/63 (66.67%), Query Frame = 3

Query:  219 SYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKL----KLEKRVSRRL 395
            +YELS+DL EK+IE  ER++GG  ++  AA  IQ ++R Y + K +  +    K EKR+SRR+
Sbjct:  300 AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRM 361

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
Match: siz (gene:FBgn0026179 transcript:FBtr0078289)

HSP 1 Score: 332.413 bits (851), Expect = 2.890e-96
Identity = 168/355 (47.32%), Postives = 238/355 (67.04%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR--DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRS-NVSPG 2264
            KR YR+ LN+FNK   KG++YLIR  F+E +P  +A+FL++RKG+SR  IG+YLG+ ++      L  F   +D+  +++D+ALR   ++F++PGE+QKI+ +ME F + Y E N     ++ ++ DTI +LA+AIIML+TD++ PN++ + +M  E+FI NLR +DD  DI+ ++L  IYDR+K+ E K  SDH  QV K+     G  +  NL  PHRRLVCYCRL+E+ D  KK+R G HQREVFLFNDLLVITK +  +KK  V Y  RN+  L    + L +   YPF IQL +  D +IL TFN R   DR +F EDL E++SE+ EM+ LRIE EL +Q+ + N +PG
Sbjct:  767 KRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRL-RSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVG--KKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITK-IFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPG 1117

HSP 2 Score: 55.4546 bits (132), Expect = 3.092e-7
Identity = 28/63 (44.44%), Postives = 42/63 (66.67%), Query Frame = 3

Query:  219 SYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKL----KLEKRVSRRL 395
            +YELS+DL EK+IE  ER++GG  ++  AA  IQ ++R Y + K +  +    K EKR+SRR+
Sbjct:  312 AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRM 373

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
Match: step (gene:FBgn0086779 transcript:FBtr0085910)

HSP 1 Score: 120.553 bits (301), Expect = 9.530e-29
Identity = 67/184 (36.41%), Postives = 109/184 (59.24%), Query Frame = 3

Query: 1239 FNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSD 1790
            FN +  KG+ YL+  + +   P  +A FL   +G+++ +IGDYLG  K+D   + LK FV + D  N  +  ALR  L  F++PGE+QKI  +ME F + Y + N    P I  N DT  +L++AIIML+T ++NP+++   K + ++FI   R +++G D+   +L ++Y+ I+T   K   D
Sbjct:   89 FNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGE-KNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLN----PDIFTNTDTCYVLSFAIIMLNTSLHNPSVKD--KPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQD 265

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Acc:ZDB-GENE-120813-1])

HSP 1 Score: 307.76 bits (787), Expect = 2.175e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP G++L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  526 KRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLVGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGVRLTSALPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 881

HSP 2 Score: 71.2478 bits (173), Expect = 4.902e-12
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   77 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 169

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Acc:ZDB-GENE-120813-1])

HSP 1 Score: 308.531 bits (789), Expect = 3.706e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP G++L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  644 KRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLVGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGVRLTSALPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 999

HSP 2 Score: 71.633 bits (174), Expect = 4.458e-12
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:  195 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 287

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1a [Source:NCBI gene;Acc:100334106])

HSP 1 Score: 303.523 bits (776), Expect = 4.171e-88
Identity = 162/358 (45.25%), Postives = 226/358 (63.13%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    F+  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+Q HRRLVCYCRLFEV D  +  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  +YP GI+L       D ++L  FN     DRKRF+ DL E+++EV EM++ RIE EL KQ+
Sbjct:  515 KRQYRIGLNLFNKKPEKGIQYLTERGFIPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDELDFSGMELDEALRKFQAQIRVQGEAQKVERLIEAFSQRYCICNHDVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKIERKMKLEDFVKNLRGVDDGEDIPREMLVGIYERIQKKELKTNEDHVSQVQKVEKLIVGKKQMGSLHHGLGCVLSQAHRRLVCYCRLFEVPDPNRLQKLGQHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVMLFENQFYPNGIRLTSAIPGADFKVLINFNAPNIQDRKRFISDLRESIAEVQEMEKYRIESELEKQK 870

HSP 2 Score: 69.707 bits (169), Expect = 1.568e-11
Identity = 40/107 (37.38%), Postives = 70/107 (65.42%), Query Frame = 3

Query:  204 RPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSY 512
            R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R YQ+ K++++L+    E R+SRR+ L   N     S+ +P  +H+   S  E  + +L +++S+
Sbjct:  127 RSLSESYELSTDLQDKKVEMLERKYGGRFITRHAARTIQTAFRHYQMNKNFERLRSSMSENRMSRRILLS--NMRMQFSFEAPEKVHS---SFFEGRQMSLMEESSH 228

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
Match: IQSEC1 (IQ motif and Sec7 domain ArfGEF 1a [Source:NCBI gene;Acc:100334106])

HSP 1 Score: 303.138 bits (775), Expect = 8.464e-88
Identity = 162/358 (45.25%), Postives = 226/358 (63.13%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    F+  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+Q HRRLVCYCRLFEV D  +  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  +YP GI+L       D ++L  FN     DRKRF+ DL E+++EV EM++ RIE EL KQ+
Sbjct:  464 KRQYRIGLNLFNKKPEKGIQYLTERGFIPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDELDFSGMELDEALRKFQAQIRVQGEAQKVERLIEAFSQRYCICNHDVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKIERKMKLEDFVKNLRGVDDGEDIPREMLVGIYERIQKKELKTNEDHVSQVQKVEKLIVGKKQMGSLHHGLGCVLSQAHRRLVCYCRLFEVPDPNRLQKLGQHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVMLFENQFYPNGIRLTSAIPGADFKVLINFNAPNIQDRKRFISDLRESIAEVQEMEKYRIESELEKQK 819

HSP 2 Score: 69.3218 bits (168), Expect = 1.758e-11
Identity = 46/144 (31.94%), Postives = 85/144 (59.03%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSYEDLVIE 530
            +R +L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R YQ+ K++++L+    E R+SRR+ L   N     S+ +P  +H+   S  E  + +L +++S+   +++
Sbjct:   52 QRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKKVEMLERKYGGRFITRHAARTIQTAFRHYQMNKNFERLRSSMSENRMSRRILLS--NMRMQFSFEAPEKVHS---SFFEGRQMSLMEESSHIGAMVQ 183

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
Match: iqsec2a (IQ motif and Sec7 domain ArfGEF 2a [Source:ZFIN;Acc:ZDB-GENE-170302-3])

HSP 1 Score: 292.352 bits (747), Expect = 1.373e-83
Identity = 159/378 (42.06%), Postives = 234/378 (61.90%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVV 2315
            +RRH   YRI LN+FNK   KG+ YLI   FV  +P  +A+F++ RKG+SR  IG++LG+ +     + L   +  +D    ++D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VD+GQDI  ++L  IY RI+  E++T  DH  QV+ +++   G  +P  L+ PHRRLVC C+L+EV D  +  R G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L ++++++F+  YY  GI+L       + ++L  FN  +  DR RF  DL E+++EV +M++ R+E EL K Q+  + PG     V+  G    E V
Sbjct:  585 QRRH---YRIGLNLFNKKPEKGIQYLIERGFVSDTPVGIARFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVLDEMDFSGMDLDDALRKFQAQIKVQGEAQKVERLVEAFSQRYCVCNPALVRQF-QNPDTIFILAFAIILLNTDMYSPNVKAERKMKLEDFIKNLRGVDNGQDIPRDLLVGIYQRIQKWELRTNDDHVSQVQAVERVIVGK-KP-VLSLPHRRLVCCCQLYEVPDPNRPQRSGVHQREVFLFNDLLVVTKIFQK-KKTSVTYSFRQSFPLVEMQVHMFQNSYYAHGIRLTSAMPGAERKVLIVFNAPSQQDRTRFTSDLRESIAEVQDMEKYRVESELEK-QKGVMRPGLLSGEVSSVGGMKTEAV 954

HSP 2 Score: 64.3142 bits (155), Expect = 7.670e-10
Identity = 29/75 (38.67%), Postives = 56/75 (74.67%), Query Frame = 3

Query:  204 RPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTH 419
            + L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R++RR+ L ++ + 
Sbjct:  105 KALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQYRMNKNFQRLRSSASESRMTRRIILSNMRSQ 179

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
Match: IQSEC2 (IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:100485600])

HSP 1 Score: 290.812 bits (743), Expect = 2.500e-82
Identity = 157/365 (43.01%), Postives = 231/365 (63.29%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVSPG 2264
            N+   +R YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  N ++D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +P  L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L  +++ LF+  YY +GI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N SPG
Sbjct:  517 NDVVQRRQYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSNMDLDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPVLVRQF-RNPDTIFILAFAIILLNTDMYSPSVKPERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGK-KPV-LSLPHRRLVCCCQLYEVPDPNRPQRMGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVDMQMQLFQNSYYQYGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGVMRPNTSPG 877

HSP 2 Score: 68.9366 bits (167), Expect = 3.869e-11
Identity = 39/107 (36.45%), Postives = 70/107 (65.42%), Query Frame = 3

Query:  186 DNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTH-----NNSSYNSPTIHATTQSILESV 482
            +N+RS + L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L ++         + S+N+P       S+ E V
Sbjct:  108 ENKRS-KALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQYSFEEYDKSHNAPYFQGKPVSLDEGV 213

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
Match: IQSEC2 (IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:100485600])

HSP 1 Score: 290.426 bits (742), Expect = 2.815e-82
Identity = 157/365 (43.01%), Postives = 231/365 (63.29%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVSPG 2264
            N+   +R YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  N ++D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +P  L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L  +++ LF+  YY +GI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N SPG
Sbjct:  509 NDVVQRRQYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSNMDLDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPVLVRQF-RNPDTIFILAFAIILLNTDMYSPSVKPERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGK-KPV-LSLPHRRLVCCCQLYEVPDPNRPQRMGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVDMQMQLFQNSYYQYGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGVMRPNTSPG 869

HSP 2 Score: 68.9366 bits (167), Expect = 3.731e-11
Identity = 39/107 (36.45%), Postives = 70/107 (65.42%), Query Frame = 3

Query:  186 DNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTH-----NNSSYNSPTIHATTQSILESV 482
            +N+RS + L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L ++         + S+N+P       S+ E V
Sbjct:  100 ENKRS-KALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQYSFEEYDKSHNAPYFQGKPVSLDEGV 205

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
Match: IQSEC2 (IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:100485600])

HSP 1 Score: 290.426 bits (742), Expect = 3.828e-82
Identity = 156/365 (42.74%), Postives = 230/365 (63.01%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVSPG 2264
            N+   +R YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  N ++D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +   L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L  +++ LF+  YY +GI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N SPG
Sbjct:  472 NDVVQRRQYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSNMDLDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPVLVRQF-RNPDTIFILAFAIILLNTDMYSPSVKPERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG--KKPVLSLPHRRLVCCCQLYEVPDPNRPQRMGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVDMQMQLFQNSYYQYGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGVMRPNTSPG 832

HSP 2 Score: 68.9366 bits (167), Expect = 4.106e-11
Identity = 39/107 (36.45%), Postives = 70/107 (65.42%), Query Frame = 3

Query:  186 DNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTH-----NNSSYNSPTIHATTQSILESV 482
            +N+RS + L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L ++         + S+N+P       S+ E V
Sbjct:   76 ENKRS-KALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQYSFEEYDKSHNAPYFQGKPVSLDEGV 181

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
Match: IQSEC2 (IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:100485600])

HSP 1 Score: 290.812 bits (743), Expect = 4.756e-82
Identity = 156/365 (42.74%), Postives = 230/365 (63.01%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVSPG 2264
            N+   +R YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  N ++D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +   L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L  +++ LF+  YY +GI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N SPG
Sbjct:  457 NDVVQRRQYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSNMDLDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPVLVRQF-RNPDTIFILAFAIILLNTDMYSPSVKPERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG--KKPVLSLPHRRLVCCCQLYEVPDPNRPQRMGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVDMQMQLFQNSYYQYGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGVMRPNTSPG 817

HSP 2 Score: 68.5514 bits (166), Expect = 5.915e-11
Identity = 39/107 (36.45%), Postives = 70/107 (65.42%), Query Frame = 3

Query:  186 DNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTH-----NNSSYNSPTIHATTQSILESV 482
            +N+RS + L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L ++         + S+N+P       S+ E V
Sbjct:   71 ENKRS-KALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQYSFEEYDKSHNAPYFQGKPVSLDEGV 176

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
Match: IQSEC2 (IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:100485600])

HSP 1 Score: 291.197 bits (744), Expect = 4.861e-82
Identity = 156/365 (42.74%), Postives = 230/365 (63.01%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVSPG 2264
            N+   +R YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  N ++D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +   L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L  +++ LF+  YY +GI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N SPG
Sbjct:  492 NDVVQRRQYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSNMDLDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPVLVRQF-RNPDTIFILAFAIILLNTDMYSPSVKPERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG--KKPVLSLPHRRLVCCCQLYEVPDPNRPQRMGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVDMQMQLFQNSYYQYGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGVMRPNTSPG 852

HSP 2 Score: 68.5514 bits (166), Expect = 5.671e-11
Identity = 39/107 (36.45%), Postives = 70/107 (65.42%), Query Frame = 3

Query:  186 DNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTH-----NNSSYNSPTIHATTQSILESV 482
            +N+RS + L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L ++         + S+N+P       S+ E V
Sbjct:   96 ENKRS-KALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQYSFEEYDKSHNAPYFQGKPVSLDEGV 201

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
Match: Iqsec1 (IQ motif and Sec7 domain 1 [Source:MGI Symbol;Acc:MGI:1196356])

HSP 1 Score: 308.145 bits (788), Expect = 1.456e-89
Identity = 167/364 (45.88%), Postives = 229/364 (62.91%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KG+ YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+V+EV EM++ RIE EL KQ+
Sbjct:  517 SNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQK 878

HSP 2 Score: 57.3806 bits (137), Expect = 9.427e-8
Identity = 40/100 (40.00%), Postives = 64/100 (64.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR  L+ S++V   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   79 RRPRLQHSTSVLRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 171

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
Match: Iqsec1 (IQ motif and Sec7 domain 1 [Source:MGI Symbol;Acc:MGI:1196356])

HSP 1 Score: 308.916 bits (790), Expect = 3.045e-89
Identity = 167/364 (45.88%), Postives = 229/364 (62.91%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KG+ YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+V+EV EM++ RIE EL KQ+
Sbjct:  607 SNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQK 968

HSP 2 Score: 57.3806 bits (137), Expect = 1.027e-7
Identity = 40/100 (40.00%), Postives = 64/100 (64.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR  L+ S++V   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:  169 RRPRLQHSTSVLRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 261

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
Match: Iqsec1 (IQ motif and Sec7 domain 1 [Source:MGI Symbol;Acc:MGI:1196356])

HSP 1 Score: 309.301 bits (791), Expect = 4.797e-89
Identity = 167/364 (45.88%), Postives = 229/364 (62.91%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KG+ YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+V+EV EM++ RIE EL KQ+
Sbjct:  503 SNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQK 864

HSP 2 Score: 57.7658 bits (138), Expect = 8.770e-8
Identity = 40/100 (40.00%), Postives = 64/100 (64.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR  L+ S++V   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   65 RRPRLQHSTSVLRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 157

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
Match: Iqsec2 (IQ motif and Sec7 domain 2 [Source:MGI Symbol;Acc:MGI:3528396])

HSP 1 Score: 289.656 bits (740), Expect = 6.081e-83
Identity = 167/404 (41.34%), Postives = 243/404 (60.15%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVS-PGYKDEHVNFPGRNSQEVVRRKDLSTFGYSTSVDEAKLSPS 2381
            +RRH   YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  + ++D ALR   S  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +P  L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L ++ + LF+  YY FGI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N S PG   + VN        + R     T+G    +    LS S
Sbjct:  548 QRRH---YRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQF-RNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGK-KP-VLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVN------GTLARSSLEDTYGAGDGLKRGALSSS 938

HSP 2 Score: 64.3142 bits (155), Expect = 7.426e-10
Identity = 30/67 (44.78%), Postives = 52/67 (77.61%), Query Frame = 3

Query:  210 LTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L
Sbjct:  114 LSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL 180

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
Match: Iqsec2 (IQ motif and Sec7 domain 2 [Source:MGI Symbol;Acc:MGI:3528396])

HSP 1 Score: 289.271 bits (739), Expect = 8.563e-82
Identity = 167/404 (41.34%), Postives = 243/404 (60.15%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL-----RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVS-PGYKDEHVNFPGRNSQEVVRRKDLSTFGYSTSVDEAKLSPS 2381
            +RRH   YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  + ++D ALR   S  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +P  L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L ++ + LF+  YY FGI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N S PG   + VN        + R     T+G    +    LS S
Sbjct:  753 QRRH---YRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQF-RNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGK-KP-VLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVN------GTLARSSLEDTYGAGDGLKRGALSSS 1143

HSP 2 Score: 63.5438 bits (153), Expect = 1.376e-9
Identity = 30/67 (44.78%), Postives = 52/67 (77.61%), Query Frame = 3

Query:  210 LTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L
Sbjct:  319 LSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL 385

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
Match: sp|Q6DN90|IQEC1_HUMAN (IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IQSEC1 PE=1 SV=1)

HSP 1 Score: 310.842 bits (795), Expect = 1.191e-89
Identity = 169/364 (46.43%), Postives = 231/364 (63.46%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRPR---NLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KGV YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G      L P     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  519 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 880

HSP 2 Score: 57.3806 bits (137), Expect = 6.944e-7
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S+++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   80 RRPKLQHSTSILRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 172

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
Match: sp|Q8R0S2|IQEC1_MOUSE (IQ motif and SEC7 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Iqsec1 PE=1 SV=2)

HSP 1 Score: 308.145 bits (788), Expect = 1.018e-88
Identity = 167/364 (45.88%), Postives = 229/364 (62.91%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KG+ YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+V+EV EM++ RIE EL KQ+
Sbjct:  517 SNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQK 878

HSP 2 Score: 57.3806 bits (137), Expect = 6.594e-7
Identity = 40/100 (40.00%), Postives = 64/100 (64.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR  L+ S++V   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR  +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   79 RRPRLQHSTSVLRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 171

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
Match: sp|Q5DU25|IQEC2_MOUSE (IQ motif and SEC7 domain-containing protein 2 OS=Mus musculus OX=10090 GN=Iqsec2 PE=1 SV=3)

HSP 1 Score: 289.656 bits (740), Expect = 2.845e-80
Identity = 166/404 (41.09%), Postives = 242/404 (59.90%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL-----RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVS-PGYKDEHVNFPGRNSQEVVRRKDLSTFGYSTSVDEAKLSPS 2381
            +RRH   YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  + ++D ALR   S  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +   L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L ++ + LF+  YY FGI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N S PG   + VN        + R     T+G    +    LS S
Sbjct:  743 QRRH---YRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQF-RNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG--KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVN------GTLARSSLEDTYGAGDGLKRGALSSS 1133

HSP 2 Score: 64.3142 bits (155), Expect = 6.202e-9
Identity = 30/67 (44.78%), Postives = 52/67 (77.61%), Query Frame = 3

Query:  210 LTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L
Sbjct:  309 LSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL 375

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
Match: sp|Q5JU85|IQEC2_HUMAN (IQ motif and SEC7 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=IQSEC2 PE=1 SV=2)

HSP 1 Score: 289.656 bits (740), Expect = 3.267e-80
Identity = 160/372 (43.01%), Postives = 233/372 (62.63%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL-----RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ---RSNVS-PGYKDEHVN 2285
            +RRH   YRI LN+FNK   KG+ YLI   F+  +P  +A F++ RKG+SR  IG++LG+ +     + L   V  +D  + ++D ALR   S  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+P+++ + KM  ++FI NLR VD+G+DI  ++L  IY RI+  E++T  DH  QV+ +++   G  +   L+ PHRRLVC C+L+EV D  +  R+G HQREVFLFNDLLV+TK  QK KK  V Y  R +  L ++ + LF+  YY FGI+L       + ++L  FN  +  DR RF  DL E+++EV EM++ R+E EL KQ+   R N S PG   + VN
Sbjct:  753 QRRH---YRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQF-RNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG--KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQK-KKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVN 1117

HSP 2 Score: 64.3142 bits (155), Expect = 6.370e-9
Identity = 30/67 (44.78%), Postives = 52/67 (77.61%), Query Frame = 3

Query:  210 LTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            L+ SYELS DL++K++E  ER++GG + S +AAR IQ+++R+Y++ K++++L+    E R+SRR+ L
Sbjct:  319 LSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL 385

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
Match: sp|Q3TES0|IQEC3_MOUSE (IQ motif and SEC7 domain-containing protein 3 OS=Mus musculus OX=10090 GN=Iqsec3 PE=1 SV=1)

HSP 1 Score: 279.641 bits (714), Expect = 2.165e-77
Identity = 154/350 (44.00%), Postives = 215/350 (61.43%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLR-----RDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KRLYRI LN+FN N  KG+ +LI   F+  +P  +A FL+ RKG+SR  IG++LG++K     + L   V  +D  N E+D ALR   +  ++ GE+QK++ ++E F + Y   N +   Q   NPDTI ILA+AII+L+TDMY+PNI+   KM  E+FI NLR VDDG DI   ++  IY+RI+  E+K+  DH   V K+++   G      L+ PHRRLVC  RLFEV D  K  +  AHQREVFLFNDLLVI K   K+K       C+    LG +  +LFE  YY  GI L       + + +  F    + + ++FVEDL E+++EV+E++++RIE EL KQQ
Sbjct:  656 KRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQF-HNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVG--MKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLG-MRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQ 1001

HSP 2 Score: 63.1586 bits (152), Expect = 1.330e-8
Identity = 31/71 (43.66%), Postives = 47/71 (66.20%), Query Frame = 3

Query:  198 SQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            S  P    YELS DL+ K+IE  E ++GG   S +AA  IQ+++R+YQL K+++K++   LE R+ RR+ L
Sbjct:  280 SHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISL 350

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
Match: I1ZIB8 (IQ motif and Sec7 domain-1 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 434.876 bits (1117), Expect = 6.561e-143
Identity = 208/210 (99.05%), Postives = 208/210 (99.05%), Query Frame = 3

Query: 1491 GESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDG-QDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEI 2117
            GESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDG QDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPF IQLRRDDEI
Sbjct:   21 GESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGSQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFXIQLRRDDEI 230

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
Match: A0A5J4NP14 (IQ motif and SEC7 domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0008865 PE=4 SV=1)

HSP 1 Score: 423.32 bits (1087), Expect = 9.840e-126
Identity = 202/374 (54.01%), Postives = 268/374 (71.66%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD-GVMYQCRNTISLGKVEIYLFETIYYPFGIQL-------------------------RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQ 2240
            E+R KRLYRI LNIFNK+ +KGV +LIR+ F++ SP+ +A+FL++RKG+SR +IGDYLG+TKD++A  T + F+R +D R +E+D ALR LLS F+ PGESQKI  ++ EFQ +Y+EQN        +NPD++M+LAYAI+MLHTDMY+PN+R Q KM++++F+ NLR VD G+D++ N+L A+YDR+   EM    DHTDQVRKI QH +G LRP NL  P RRLVCYCRL+EV D  KK+R GAHQREVFLFNDLL++TKGVQK++KD  + YQ R +++L  V +  FET ++P G++L                              IL T NT+T SDR RF+EDL E + EV+EMDRLRIEEE+ KQ
Sbjct:  761 EKRRKRLYRIGLNIFNKSPIKGVDFLIRYNFLDCSPDTIARFLLTRKGLSRIAIGDYLGNTKDEMAVVTTQQFMRELDFREQEVDEALRSLLSCFRTPGESQKIVHLLTEFQSAYVEQNSARVKAQFRNPDSVMVLAYAIVMLHTDMYSPNVRTQSKMTRDQFVRNLRGVDGGEDLDRNLLLAVYDRVHLCEMTVLPDHTDQVRKIQQHLTGPLRPINLALPSRRLVCYCRLYEVPDKNKKERPGAHQREVFLFNDLLLVTKGVQKKRKDAAIAYQVRASLNLLGVRLITFETPHHPHGLELVLPIPERTEAVNAKESGLTGSALPPASQARILITLNTKTMSDRARFMEDLQECILEVTEMDRLRIEEEVAKQ 1134

HSP 2 Score: 97.0561 bits (240), Expect = 1.445e-16
Identity = 59/151 (39.07%), Postives = 88/151 (58.28%), Query Frame = 3

Query:  216 VSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVK---------NNLKKQNSYEDLVIEQAYRDW--DRDISQDLIDANTKTIEPKCVTNDEHKSA 635
            +SYEL EDLR KEIE  ER +GGR ++ +AAR+IQ++YREY+LR +Y ++ LEK   R+ D  S  + N  +++S  +  T+   L+ VK         + L+   S EDLV+EQAY DW      +Q    A+T + +  C   +E  S+
Sbjct:  233 LSYELGEDLRAKEIELIERCYGGRMRAQRAARIIQNAYREYRLRTEYARICLEK---RKPD--SCASANVLAFSSKHVLTTSTRALDDVKFLNGSCPVRSTLRSSGSLEDLVLEQAYVDWALKAATAQTSCGASTNS-DSACAVGNEQTSS 377

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
Match: A0A183A8K0 (SEC7 domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS3285 PE=4 SV=1)

HSP 1 Score: 414.461 bits (1064), Expect = 5.720e-125
Identity = 199/375 (53.07%), Postives = 267/375 (71.20%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD-GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRD--------------------------DEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQ 2240
            E+R KR+YRI LNIFNK+ LKG+ +LI++ F++ +P  +A+FL++RKG+SR +IGDYLG+TKD+LA  T + F+R +D R +E+D ALR LLS F+ PGESQKI  ++ EFQ +Y+EQN        +NPD++M+LAYAI+MLHTDMY+PN+R Q KM+++EF+ NLR VD G+D++ N+L AIYDRI+  EM    DHTDQVRKI QH +G LRP NL  P RRLVCYCRL+EV D  K++R GAHQREVFLFNDLL+ITK VQK+++D  + YQ R +++L  V +  FET ++P G++L                               IL T NT+T SDR RF+EDL E + EV+EMDR+RIE+E+ KQ
Sbjct:  453 EKRRKRIYRIGLNIFNKSPLKGIEFLIKYGFLDCTPETVARFLLTRKGLSRVAIGDYLGNTKDELAMTTTRQFMRELDFREQEVDDALRSLLSCFRTPGESQKIVHLLTEFQAAYIEQNSARVKAQFRNPDSVMVLAYAIVMLHTDMYSPNVRPQSKMTRDEFVRNLRGVDAGEDLDRNLLLAIYDRIQQREMSVAPDHTDQVRKIQQHLTGPLRPLNLALPQRRLVCYCRLYEVPDKNKRERPGAHQREVFLFNDLLLITKAVQKKRRDAAIAYQVRVSLNLLGVRLVAFETPHHPHGLELLLPIGESNVSLNSKESGLNPAAPLTPDGRARILVTLNTKTLSDRARFMEDLQECIVEVAEMDRIRIEDEVAKQ 827

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
Match: A0A504YVF3 (IQ motif and SEC7 domain-containing protein 1 OS=Fasciola gigantica OX=46835 GN=FGIG_07309 PE=4 SV=1)

HSP 1 Score: 419.468 bits (1077), Expect = 7.861e-125
Identity = 201/377 (53.32%), Postives = 268/377 (71.09%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD-GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRD--------------------------DEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQR 2246
            E+R KR+YRI LNIFNK+ LKGV +LI++ F++ +P  +A+FL++RKG+SR +IGDYLG+TKD+LA  T + F+R +D R +E+D ALR LLS F+ PGESQKI  ++ EFQ +Y+EQN        +N D++M+LAYAI+MLHTDMY+PN+R Q KM+++EF+ NLR VD G+D++ N+L AIYDRI+  EM   +DHTDQVRKI QH +G LRP NL  P RRLVCYCRL+EV D  K++R G+HQREVFLFNDLL+ITK VQK+++D  V YQ R ++SL  + +  FET Y+P G++L                               IL T NT+T SDR RF+EDL E + EV+EMDR+RIEEE+ KQ +
Sbjct:  677 EKRRKRVYRIGLNIFNKSPLKGVEFLIKYGFLDCAPETIARFLLTRKGLSRVAIGDYLGNTKDELAMTTTRQFMRELDFREQEVDEALRSLLSCFRTPGESQKIVHLLTEFQAAYVEQNSARVKAQFRNVDSVMVLAYAIVMLHTDMYSPNVRPQSKMTRDEFVRNLRGVDAGEDLDRNLLLAIYDRIQQREMSVAADHTDQVRKIQQHLTGPLRPLNLAIPQRRLVCYCRLYEVPDKNKRERPGSHQREVFLFNDLLLITKAVQKKRRDAAVAYQVRISLSLLGIRLTAFETAYHPHGLELLLPVGESNISLNSKESGLNPAAPFTTDGRARILVTLNTKTLSDRARFMEDLQECIVEVAEMDRIRIEEEVIKQMQ 1053

HSP 2 Score: 101.679 bits (252), Expect = 5.287e-18
Identity = 62/146 (42.47%), Postives = 83/146 (56.85%), Query Frame = 3

Query:  183 YDNQRSQRPL-----TVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLKLEKRVSRRLD-LPSINTHNNSSYNSPTIHATTQSILESVKNNLKKQN------------------SYEDLVIEQAYRDW 548
            +D   S RPL      VSYELSEDLR KEIE  ER +GGR ++ +AARVIQ+ YR+Y+LR +Y +L+LEK  +R+LD +P ++    SS  +     T  +IL      L ++N                  S EDLV+EQAY DW
Sbjct:   96 HDALGSPRPLRSDLANVSYELSEDLRAKEIELIERCYGGRLRAQRAARVIQNCYRDYRLRTEYARLRLEKCSNRKLDPIPQMSPTVKSSCAT-VCGTTIPTILSPPSTGLAQKNESHLSSSPYRRPALHSSGSLEDLVLEQAYVDW 240

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
Match: A0A4E0RD19 (IQ motif and SEC7 domain-containing protein 1 OS=Fasciola hepatica OX=6192 GN=D915_004509 PE=4 SV=1)

HSP 1 Score: 418.313 bits (1074), Expect = 1.919e-124
Identity = 201/377 (53.32%), Postives = 268/377 (71.09%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKD-GVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRD--------------------------DEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQR 2246
            E+R KR+YRI LNIFNK+ LKGV +LI++ F++ +P  +A+FL++RKG+SR +IGDYLG+TKD+LA  T + F+R +D R +E+D ALR LLS F+ PGESQKI  ++ EFQ +Y+EQN        +N D++M+LAYAI+MLHTDMY+PN+R Q KM+++EF+ NLR VD G+D++ N+L AIYDRI+  EM   +DHTDQVRKI QH +G LRP NL  P RRLVCYCRL+EV D  K++R G+HQREVFLFNDLL+ITK VQK+++D  V YQ R ++SL  + +  FET Y+P G++L                               IL T NT+T SDR RF+EDL E + EV+EMDR+RIEEE+ KQ +
Sbjct:  677 EKRRKRVYRIGLNIFNKSPLKGVEFLIKYGFLDCAPETIARFLLTRKGLSRVAIGDYLGNTKDELAMTTTRQFMRELDFREQEVDEALRSLLSCFRTPGESQKIVHLLTEFQAAYVEQNSARVKAQFRNVDSVMVLAYAIVMLHTDMYSPNVRPQSKMTRDEFVRNLRGVDAGEDLDRNLLLAIYDRIQQREMSVAADHTDQVRKIQQHLTGPLRPLNLAIPQRRLVCYCRLYEVPDKNKRERPGSHQREVFLFNDLLLITKAVQKKRRDAAVAYQVRISLSLLGIRLTAFETAYHPHGLELLLPVGESNISLNSKESGLNPAAPFTTDGRARILVTLNTKTLSDRARFMEDLQECIVEVAEMDRIRIEEEVVKQMQ 1053

HSP 2 Score: 102.834 bits (255), Expect = 2.254e-18
Identity = 65/162 (40.12%), Postives = 88/162 (54.32%), Query Frame = 3

Query:  135 SAVDTHQFQVNCINVSYDNQRSQRPL-----TVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLKLEKRVSRRLD-LPSINTHNNSSYNSPTIHATTQSILESVKNNLKKQN------------------SYEDLVIEQAYRDW 548
            S +D+    V      +D   S RPL      VSYELSEDLR KEIE  ER +GGR ++ +AARVIQ+ YR+Y+LR +Y +L+LEK  +R+LD +P ++    SS  +     T  +IL      L ++N                  S EDLV+EQAY DW
Sbjct:   80 SCLDSGCLVVRDFGTDHDALGSPRPLRSDLANVSYELSEDLRAKEIELIERCYGGRLRAQRAARVIQNCYRDYRLRTEYARLRLEKCSNRKLDPIPQMSPTVKSSCAT-VCGTTIPTILSPPSTGLAQKNESHPSSSPYRRPALHSSGSLEDLVLEQAYVDW 240

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1-like [Source:NCBI gene;Acc:103026485])

HSP 1 Score: 308.531 bits (789), Expect = 9.206e-89
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L +FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  503 KRYYRIGLNLFNKKPEKGIQYLTERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRQKELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADVKVLISFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 858

HSP 2 Score: 71.2478 bits (173), Expect = 4.343e-12
Identity = 48/144 (33.33%), Postives = 81/144 (56.25%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSYEDLVIE 530
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++   ER++GGR+ S  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L   N     S+  P  +H+   S  E  + +L  + S    V++
Sbjct:   56 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVAMLERKYGGRFISRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLS--NMRMQFSFEGPEKVHS---SFFEGKQMSLSDEGSQMGAVVQ 187

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1-like [Source:NCBI gene;Acc:103026485])

HSP 1 Score: 308.531 bits (789), Expect = 1.075e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L +FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  519 KRYYRIGLNLFNKKPEKGIQYLTERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRQKELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADVKVLISFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 874

HSP 2 Score: 71.2478 bits (173), Expect = 4.113e-12
Identity = 48/144 (33.33%), Postives = 81/144 (56.25%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSYEDLVIE 530
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++   ER++GGR+ S  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L   N     S+  P  +H+   S  E  + +L  + S    V++
Sbjct:   72 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVAMLERKYGGRFISRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLS--NMRMQFSFEGPEKVHS---SFFEGKQMSLSDEGSQMGAVVQ 203

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1-like [Source:NCBI gene;Acc:103026485])

HSP 1 Score: 308.531 bits (789), Expect = 1.129e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L +FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  524 KRYYRIGLNLFNKKPEKGIQYLTERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRQKELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADVKVLISFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 879

HSP 2 Score: 71.2478 bits (173), Expect = 4.050e-12
Identity = 48/144 (33.33%), Postives = 81/144 (56.25%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSYEDLVIE 530
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++   ER++GGR+ S  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L   N     S+  P  +H+   S  E  + +L  + S    V++
Sbjct:   77 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVAMLERKYGGRFISRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLS--NMRMQFSFEGPEKVHS---SFFEGKQMSLSDEGSQMGAVVQ 208

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1-like [Source:NCBI gene;Acc:103026485])

HSP 1 Score: 308.531 bits (789), Expect = 1.243e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L +FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  523 KRYYRIGLNLFNKKPEKGIQYLTERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRQKELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADVKVLISFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 878

HSP 2 Score: 71.2478 bits (173), Expect = 3.981e-12
Identity = 48/144 (33.33%), Postives = 81/144 (56.25%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSYEDLVIE 530
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++   ER++GGR+ S  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L   N     S+  P  +H+   S  E  + +L  + S    V++
Sbjct:   76 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVAMLERKYGGRFISRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLS--NMRMQFSFEGPEKVHS---SFFEGKQMSLSDEGSQMGAVVQ 207

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1-like [Source:NCBI gene;Acc:103026485])

HSP 1 Score: 308.531 bits (789), Expect = 1.253e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   +L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L +FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  527 KRYYRIGLNLFNKKPEKGIQYLTERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRQKELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADVKVLISFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 882

HSP 2 Score: 71.633 bits (174), Expect = 3.885e-12
Identity = 48/144 (33.33%), Postives = 81/144 (56.25%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDLPSINTHNNSSYNSP-TIHATTQSILESVKNNLKKQNSYEDLVIE 530
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++   ER++GGR+ S  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L   N     S+  P  +H+   S  E  + +L  + S    V++
Sbjct:   80 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSTDLQDKQVAMLERKYGGRFISRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLS--NMRMQFSFEGPEKVHS---SFFEGKQMSLSDEGSQMGAVVQ 211

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007609.1 (pep scaffold:Pmarinus_7.0:GL477333:80854:108205:-1 gene:ENSPMAG00000006851.1 transcript:ENSPMAT00000007609.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 309.686 bits (792), Expect = 1.114e-95
Identity = 164/361 (45.43%), Postives = 231/361 (63.99%), Query Frame = 3

Query: 1194 NERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLN------QPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL-----RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            N+   KRLYRI LN+FNK + KG+ +L+   F+  +P  +A+FL+ RKG+SR  IGD+LG+ +     + L   V  +D    +ID ALR      ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TD Y+PN++ + KM  E+FI NLR VDDG+DI   +L +IYDRI   E+KT  DH  QV K+++   G    R L+       PHRRLVCYCRLFEV D  +  ++G HQRE+FLFND LV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI++       D ++L  FN    +DRK+FV+DL E+++EV EM+++RIE EL KQ+
Sbjct:   32 NDVIRKRLYRIGLNLFNKKAEKGLQFLMERGFIPDTPYGVAQFLLQRKGLSRQMIGDFLGNRQKQFNRDVLDCVVEEMDFAGMDIDEALRKFQGQVRVQGEAQKVERMIEAFSQRYCVCNSVLLRQF-RNPDTIFILAFAIILLNTDRYSPNVKAERKMKLEDFIKNLRGVDDGKDIPREMLLSIYDRISKKELKTNEDHVSQVAKVEKSIVGKKPVRGLHVHCVLALPHRRLVCYCRLFEVPDTNRPQKLGLHQREIFLFNDFLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIKIVSAVPGADTKVLMVFNAPNPTDRKKFVDDLRESIAEVQEMEKIRIESELDKQK 390

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Acc:ZDB-GENE-120813-1])

HSP 1 Score: 301.597 bits (771), Expect = 3.609e-88
Identity = 167/378 (44.18%), Postives = 230/378 (60.85%), Query Frame = 3

Query: 1167 QKSCYCQA-ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKN---PDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRP----------RNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL-----RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            Q  C   A +N+   KR YRI LN+FNK   KGV+YL+   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N    P + KN   PDTI ILA+AI++L+TDMY+PN++ + KM  ++F+ NLR VDDG DI   IL  IY+RI+  E+KT  DH  QV  +++   G  +P          + L+ PHRRLVCYCRLFEV D  +  ++G HQRE+FLFNDLLV+TK   KRK     Y  R +  L  ++++LFE  YY  GI+L       + EIL  FN     DRK+FVEDL E+ SEV EM++ RIE EL KQ+
Sbjct:  445 QGGCDSPAFSNDIIRKRQYRIGLNLFNKKPEKGVAYLMERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQRAFNRDVLDCVVDEMDFSGMELDEALRMFQAHIRVQGEAQKVERLIEAFSQRYCMCN----PGVVKNFQNPDTIFILAFAIVLLNTDMYSPNVKPERKMKLDDFVKNLRGVDDGADIPREILVGIYERIQRGELKTNDDHVTQVANVEKTIVGK-KPVIVLIHKNIQKVLSLPHRRLVCYCRLFEVPDPNRPQKLGLHQREIFLFNDLLVVTKIFHKRKHS-TSYSFRQSFPLYGMQVHLFENQYYQHGIRLVSSTPGSETEILVIFNAPNPEDRKKFVEDLKESTSEVQEMEKYRIEVELEKQK 816

HSP 2 Score: 67.781 bits (164), Expect = 9.894e-12
Identity = 41/106 (38.68%), Postives = 67/106 (63.21%), Query Frame = 3

Query:  111 RRSELRRS-SAVDTHQFQVN-CINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSR--RLDLPS 407
            RR+  +RS SA+   Q Q +     +    R +  L  SYELS DL++K++E  ER++GG Y S +AA  IQ+++REYQ++K +++++    E RVS+  R+ LP+
Sbjct:   16 RRASFQRSNSALRRAQQQADDGTTAATAAARRKHSLAGSYELSSDLQDKQVEMLERKYGGHYISRRAACTIQTAFREYQMKKQFRRIRDSMCENRVSKGTRMQLPT 121

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Acc:ZDB-GENE-120813-1])

HSP 1 Score: 227.254 bits (578), Expect = 2.988e-67
Identity = 117/241 (48.55%), Postives = 159/241 (65.98%), Query Frame = 3

Query: 1581 NPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHF---------------SGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            NPDTI ILA+AII+L+TDMY+PN++ + KM  ++F+ NLR VDDG DI   IL  IY+RI+  E++T  DH  QV K+++                  GH     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  Q RKK+ VMY  R + SL  ++++LFE  +YP GI++       + ++LA FN     DRK+FV+DL E+++EV EM++ RIE EL KQ+
Sbjct:   17 NPDTIFILAFAIILLNTDMYSPNVKPERKMRLDDFVKNLRGVDDGADIPREILVGIYERIQKQELRTNDDHVTQVTKVEKSIVGKKPVMPATSRPSVRGHGDKNALSLPHRRLVCYCRLFEVPDPTKPQKLGLHQREIFLFNDLLVVTKIFQ-RKKNAVMYSFRQSFSLYGMQVHLFENQFYPHGIKIMSAVPGAETKVLALFNAPNPQDRKKFVDDLKESIAEVQEMEKHRIETELEKQK 256

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Acc:ZDB-GENE-120813-1])

HSP 1 Score: 231.491 bits (589), Expect = 1.144e-66
Identity = 117/232 (50.43%), Postives = 161/232 (69.40%), Query Frame = 3

Query: 1581 NPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGH-----LRP-RNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            NPDTI ILA+AII+L+TDMY+PN++ + KM  ++F+ NLR VDDG DI   IL  IY+RI+  E++T  DH  QV K+++   G      L P   L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK + +RKK+ VMY  R + SL  ++++LFE  +YP GI++       + ++LA FN     DRK+FV+DL E+++EV EM++ RIE EL KQ+
Sbjct:   17 NPDTIFILAFAIILLNTDMYSPNVKPERKMRLDDFVKNLRGVDDGADIPREILVGIYERIQKQELRTNDDHVTQVTKVEKSIVGKKPVIPLHPFLALSLPHRRLVCYCRLFEVPDPTKPQKLGLHQREIFLFNDLLVVTK-IFQRKKNAVMYSFRQSFSLYGMQVHLFENQFYPHGIKIMSAVPGAETKVLALFNAPNPQDRKKFVDDLKESIAEVQEMEKHRIETELEKQK 247

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001471.1 (pep scaffold:Pmarinus_7.0:GL477283:166775:173339:-1 gene:ENSPMAG00000001328.1 transcript:ENSPMAT00000001471.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 128.642 bits (322), Expect = 2.000e-34
Identity = 67/177 (37.85%), Postives = 108/177 (61.02%), Query Frame = 3

Query: 1242 NKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKF---FVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIK 1763
            N+   KG+++L+   FV  + +  A FL+ RKG+SR  IG++LG+ +     + L+    FV  +D    E+D ALR   +  ++ GE+QK++ ++E F   Y   N      +C   DT+ +LA+AI++L+TDMY+P++R   KM  ++FI NLR VDDG+DI  + L  IY+RI+
Sbjct:    1 NRKPEKGLAFLVSRGFVGATASAAAHFLLQRKGLSRQMIGEFLGNRQRPFNRDVLEVSRCFVDEMDFSGLELDEALRLFQTHVRLQGEAQKVERLVEVFSRRYCACNPAVVSALCSE-DTVFVLAFAIVLLNTDMYSPSVRHDRKMRLDDFIKNLRGVDDGEDIPRDFLVGIYERIR 176

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Yeast
Match: SEC7 (Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles [Source:SGD;Acc:S000002577])

HSP 1 Score: 117.857 bits (294), Expect = 3.278e-27
Identity = 69/205 (33.66%), Postives = 112/205 (54.63%), Query Frame = 3

Query: 1182 CQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFV-EPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDH 1793
             Q  N +  K     C+ IFN    K +  LI+  F+ + SP  +AK+L+  +G+   ++GDYLG   DD     +  FV   D     I  ALR  L  F++PGE QKI   M +F E +++QN    P +    DT  +L+Y++IML+TD+++  I+  +KMS +EF+ N   +D+G+D+  + L  +++ I   E+K  S+ 
Sbjct:  819 TQFENLKLRKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWLLETEGLDMAAVGDYLGE-GDDKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQN----PGVFSKADTAYVLSYSLIMLNTDLHSSQIK--NKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANNEIKLISEQ 1016

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Yeast
Match: GEA1 (Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication [Source:SGD;Acc:S000003792])

HSP 1 Score: 88.1965 bits (217), Expect = 4.126e-18
Identity = 68/224 (30.36%), Postives = 113/224 (50.45%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPN-ILAKFLMSRKG-ISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESY-----------------------MEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDH 1793
            +R  K  + +C+  FN+ + KG+  LI   F++   N  +A FL    G +++ +IG  L   K    T  LK F+ + D +   +D A+R LL+ F++PGESQ+I+ I+E F   Y                       M ++     Q   + D++ +L+Y+IIML+TD +NP + K H M+ +++ +NLR   +G+D     L  IY  IK  E+    +H
Sbjct:  538 QRDRKTEFILCVETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPK---KTSLLKEFIDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIHVQ--PDADSVFVLSYSIIMLNTDSHNPQV-KDH-MTFDDYSNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEH 754

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Yeast
Match: GEA2 (Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication [Source:SGD;Acc:S000000748])

HSP 1 Score: 86.6557 bits (213), Expect = 1.198e-17
Identity = 68/213 (31.92%), Postives = 112/213 (52.58%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEP-SPNILAKFLMSRKG-ISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQ------------ICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDH 1793
            +R  K  +  C N FN+   KG+  LI   F+   S   +A+FL +    +++ +IG  L H         L  ++R+ D     +D A+R LL+ F++PGESQ+I+ I+E F  +Y E NQ + P             +  + D++ IL+Y+IIML+TD++NP + K+H MS E++  NL+   + +D     L  IY  I+  E+    +H
Sbjct:  556 KRDRKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPD---KVSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCE-NQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQV-KEH-MSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEH 762

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Yeast
Match: SYT1 (Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain [Source:SGD;Acc:S000006299])

HSP 1 Score: 71.633 bits (174), Expect = 4.312e-13
Identity = 46/164 (28.05%), Postives = 82/164 (50.00%), Query Frame = 3

Query: 1320 FLMSRKGISRFSIGDYLGHTKDDLATETLKFFV-RMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQ-----ICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRN--VDDGQDINPNILTAIYDRIKTAEMKTFS 1787
            FL+      +F IG  L    D+     L + +    + +N  +DIALR LL F ++P E+Q+I  ++  F  +Y +  + +  +        N D +  +A++++MLHTD +NPN   + KM+K +F+  + N     G +I   +LT  Y+ +   E   F+
Sbjct:  466 FLIKLAPYGKF-IGIILTEKDDEFKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQVYFIAFSLLMLHTDYFNPN--NKSKMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKESPKFN 626

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
Match: EDO34882 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SN35])

HSP 1 Score: 231.491 bits (589), Expect = 2.651e-66
Identity = 131/351 (37.32%), Postives = 203/351 (57.83%), Query Frame = 3

Query: 1188 AANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQK-RKKDGV-MYQCRNTISLGKVEIYLFETIYYPFGIQL--RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEE 2228
            AA+ +  K   RI +N FN+   KGV+YLI  + ++ +P  +AKFL+S  G+S+  +G+YLG+ ++D     LK F    D    EID+ALR  L+ F+IPGE+QKI+ +ME F E Y+  N           D ++ILA+AI+ML+TD+++PN++K  +M++E+FI NL   ++G +     L  IY R+   E     DH     K+++   G +    L   HR L     LFE+ D  KK++   H R +F+FND++V+TK   +  ++DG   Y  +++  L  V+I +F   YYP+GIQL  R   +++ATFN      RK FVE+L+E + E + M+  RI  E
Sbjct:   26 AADLKPQKLEMRIGINQFNRKPEKGVTYLIAHQVIDDNPEAVAKFLLSEHGVSKQRLGEYLGNLQNDFNMAVLKCFAESFDFTGMEIDVALRTFLAQFRIPGEAQKIERLMEVFAEQYISCNPT---DDTSAQDKVLILAFAIVMLNTDLHSPNVKK--RMTQEDFIRNLEGTNNGGNFPSESLAGIYRRVFKKEFTPARDHVTMTAKLEKKIVGKMPWTTLAALHRYLRMLTPLFEIRDPNKKEK--THPRVIFVFNDMIVVTKERGRPGQRDGYHFYSYKHSFLLSGVKISVFTNDYYPWGIQLYSRLQSQVVATFNATDERTRKVFVEELLECIEETNAMENDRIATE 369

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
Match: EDO38004 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEA8])

HSP 1 Score: 115.546 bits (288), Expect = 1.900e-27
Identity = 65/187 (34.76%), Postives = 109/187 (58.29%), Query Frame = 3

Query: 1239 FNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDM---RNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSD 1790
            F+ +  KG+ YL+    +  +P  LA FL+  +G+++  IG+YLG  K+      L  F + VD+   ++  +  ALR  L  F++PGE+QKI  +ME F + Y   N    P +  + DT  +L++AII+L+T ++NPN++   K + E+FI   R ++ G+D++ + L A+YD IK+ E K   D
Sbjct:   68 FSMDPQKGIDYLVMHGLLNNTPEDLADFLLKEEGLNKTQIGNYLGENKE----FNLDVFAKFVDLHKFKDMILVQALRQFLWSFRLPGEAQKIDRMMEAFAQKYCADN----PGLFTSTDTCYVLSFAIILLNTSLHNPNVK--DKPTVEKFIQMNRGINCGEDLDRDFLVALYDSIKSEEFKIPED 244

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
Match: EDO31538 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXN1])

HSP 1 Score: 111.694 bits (278), Expect = 6.806e-25
Identity = 67/205 (32.68%), Postives = 109/205 (53.17%), Query Frame = 3

Query: 1200 RRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEP--SPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVR 1808
            ++ K+L +     FN    KG+ +L     +     P  +A+ L     + + +IG+Y+G  KD+  ++ L  FVR  +  +  +D  LR  L  F++PGES  I+ IME F E + E N    P++  N D +  LAYA+IML+ D +N NI++Q  M  E+F  NLR ++ G D    +L  I+  IK  E+   ++ T ++R
Sbjct:  674 KQRKKLLQAGSEHFNNKPKKGIEFLQEHGLLHTPLDPEEMARLLRENPRLDKKTIGEYIGK-KDN--SKVLDAFVRSFEFHDLRVDEGLRQFLESFRLPGESPVIEHIMEFFSEVFFECN----PEVYANKDAVFTLAYAVIMLNVDQHNANIKQQKPMVLEDFKRNLRKINGGNDFPATMLEEIFTCIKNEEIVMPAERTGRIR 871

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
Match: EDO41902 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S350])

HSP 1 Score: 105.145 bits (261), Expect = 7.514e-23
Identity = 59/180 (32.78%), Postives = 102/180 (56.67%), Query Frame = 3

Query: 1239 FNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMK 1778
            FNKN  KG+ +L     +  S   +A+FL   + + +  IG+ +G   DD + + +  +V  +D  + E   +LR  L+ F++PGE+QKI  +ME+F   Y + N      +  + D   +LAY+IIML TD++NP +++  K++KE++    R ++D +D+    L  IYD I+  E+K
Sbjct:  691 FNKNPKKGMKFLQENGLLGMSAGEVAEFLHGDERLDKMQIGELIG-DNDDFSKQVMYEYVDKLDFTDMEFVSSLRLFLTNFRLPGEAQKIDRLMEKFASRYFDTNPN--NSVFASADAAYVLAYSIIMLTTDLHNPQVKR--KITKEQYCSMNRGINDSKDLPQEYLEGIYDEIQHNEIK 865

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
Match: EDO29395 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T3S2])

HSP 1 Score: 87.8113 bits (216), Expect = 2.093e-19
Identity = 40/91 (43.96%), Postives = 61/91 (67.03%), Query Frame = 3

Query: 1257 KGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEF 1529
            KGV+YLI  + ++ +P  +AKFL+S  G+S+  +G+YLG+ ++D     LK F    D    EID+ALR  L+ F+IPGE+QKI+ +ME+ 
Sbjct:   78 KGVTYLIAHQVIDDNPEAVAKFLLSEHGVSKQRLGEYLGNLQNDFNMAVLKCFAESFDFTGMEIDVALRTFLAQFRIPGEAQKIERLMEDI 168

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1 [Source:NCBI gene;Acc:101172493])

HSP 1 Score: 306.22 bits (783), Expect = 1.468e-88
Identity = 165/364 (45.33%), Postives = 230/364 (63.19%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KG+ YL    F+  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D ++ E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  583 SNDVIRKRHYRIGLNLFNKKPEKGIQYLTERGFIPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFQSMELDEALRKFQNHIRVQGEAQKVERLIEAFSQRYCICNPTVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRETLVGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADMKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 944

HSP 2 Score: 71.633 bits (174), Expect = 3.548e-12
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:  134 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSADLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 226

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1 [Source:NCBI gene;Acc:101157125])

HSP 1 Score: 306.99 bits (785), Expect = 2.753e-88
Identity = 164/358 (45.81%), Postives = 226/358 (63.13%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQ--------PHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG  YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   IL  IY+RI+  E++T  DH  QV+K+++   G     +L+Q        PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YY  G++L       D ++L  FN     DRKRF +DL E+++EV EM++ RIE EL KQ+
Sbjct:  514 KRHYRIGLNLFNKKPEKGTQYLIDRNFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIKVQGEAQKVERLIEAFSQRYCICNPGVVQQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREILVGIYERIRKRELRTNEDHVSQVQKVEKLIVGKKPIGSLHQGIGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYTNGVRLTSAIPGADIKVLINFNAPNPQDRKRFTDDLRESIAEVQEMEKYRIESELEKQK 869

HSP 2 Score: 60.077 bits (144), Expect = 1.206e-8
Identity = 40/100 (40.00%), Postives = 66/100 (66.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RRS+L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   75 RRSKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 167

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
Match: iqsec1b (IQ motif and Sec7 domain ArfGEF 1 [Source:NCBI gene;Acc:101157125])

HSP 1 Score: 306.605 bits (784), Expect = 3.319e-88
Identity = 164/358 (45.81%), Postives = 226/358 (63.13%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQ--------PHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG  YLI   FV  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D    E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+F+ NLR VDDG+DI   IL  IY+RI+  E++T  DH  QV+K+++   G     +L+Q        PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YY  G++L       D ++L  FN     DRKRF +DL E+++EV EM++ RIE EL KQ+
Sbjct:  498 KRHYRIGLNLFNKKPEKGTQYLIDRNFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIKVQGEAQKVERLIEAFSQRYCICNPGVVQQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREILVGIYERIRKRELRTNEDHVSQVQKVEKLIVGKKPIGSLHQGIGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYTNGVRLTSAIPGADIKVLINFNAPNPQDRKRFTDDLRESIAEVQEMEKYRIESELEKQK 853

HSP 2 Score: 59.6918 bits (143), Expect = 1.377e-8
Identity = 40/100 (40.00%), Postives = 66/100 (66.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RRS+L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   59 RRSKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSSDLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 151

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1 [Source:NCBI gene;Acc:101172493])

HSP 1 Score: 306.99 bits (785), Expect = 3.356e-88
Identity = 165/364 (45.33%), Postives = 230/364 (63.19%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            +N+   KR YRI LN+FNK   KG+ YL    F+  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D ++ E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  524 SNDVIRKRHYRIGLNLFNKKPEKGIQYLTERGFIPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFQSMELDEALRKFQNHIRVQGEAQKVERLIEAFSQRYCICNPTVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRETLVGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADMKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 885

HSP 2 Score: 72.0182 bits (175), Expect = 2.372e-12
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   75 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSADLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 167

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
Match: IQSEC1 (IQ motif and SEC7 domain-containing protein 1 [Source:NCBI gene;Acc:101172493])

HSP 1 Score: 306.99 bits (785), Expect = 4.298e-88
Identity = 164/358 (45.81%), Postives = 227/358 (63.41%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSG--------HLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRR-----DDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQ 2243
            KR YRI LN+FNK   KG+ YL    F+  +P  +A FL+ RKG+SR  IG++LG+ +     + L   V  +D ++ E+D ALR   +  ++ GE+QK++ ++E F + Y   N     Q  +NPDTI ILA+AII+L+TDMY+PN++ + KM  E+FI NLR VDDG+DI    L  IY+RI+  E+KT  DH  QV+K+++   G        H     L+ PHRRLVCYCRLFEV D  K  ++G HQRE+FLFNDLLV+TK  QK KK+ V Y  R + SL  +++ LFE  YYP GI+L       D ++L  FN     DRK+F +DL E+++EV EM++ RIE EL KQ+
Sbjct:  548 KRHYRIGLNLFNKKPEKGIQYLTERGFIPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFQSMELDEALRKFQNHIRVQGEAQKVERLIEAFSQRYCICNPTVVRQF-RNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRETLVGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKLQKLGLHQREIFLFNDLLVVTKIFQK-KKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAIPGADMKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK 903

HSP 2 Score: 72.0182 bits (175), Expect = 2.510e-12
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3

Query:  111 RRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLK---LEKRVSRRLDL 401
            RR +L+ S ++   Q +   I  S       R L+ SYELS DL++K++E  ER++GGR+ +  AAR IQ+++R+YQ+ K++++L+    E R+SRR+ L
Sbjct:   93 RRPKLQHSQSILRKQAEEEAIKRS-------RSLSESYELSADLQDKQVEMLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVL 185

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST
Match: SMESG000057299.1 (SMESG000057299.1)

HSP 1 Score: 1605.5 bits (4156), Expect = 0.000e+0
Identity = 814/818 (99.51%), Postives = 817/818 (99.88%), Query Frame = 3

Query:   90 MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVKNNLKKQNSYEDLVIEQAYRDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDXXXXXXXXXXXXXGTFXXXXXXXXXXXXXXNNLSTCASKCIGXXXXXXXXXXXXPCQKSIVAVSDSKKPTLPKCNKPIPISHSTTLCDTKRQGSLSKTCPGNVTVCCDLNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLSNPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTFGYSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNVYNQQNRISGDSGLQEDIE 2543
            MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAAR+IQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVKN+LKKQNSYEDLVIEQAYRDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDASSMSMTPSPTAPGTFSILSSSPSLVISKSNNLSTCASKCIGSSSNSAIINSSSPCQKSIVAVSDSKKPTLPKCNKPIPISHSTTLCDT+RQGSLSKTCPGNVTVCCDLNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLSNPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTF YSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNVYNQQNRISGDSGLQEDIE
Sbjct:    1 MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARIIQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVKNDLKKQNSYEDLVIEQAYRDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDASSMSMTPSPTAPGTFSILSSSPSLVISKSNNLSTCASKCIGSSSNSAIINSSSPCQKSIVAVSDSKKPTLPKCNKPIPISHSTTLCDTRRQGSLSKTCPGNVTVCCDLNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLSNPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTFVYSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNVYNQQNRISGDSGLQEDIE 818

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST
Match: SMESG000057299.1 (SMESG000057299.1)

HSP 1 Score: 1577.76 bits (4084), Expect = 0.000e+0
Identity = 782/818 (95.60%), Postives = 789/818 (96.45%), Query Frame = 3

Query:   90 MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVKNNLKKQNSYEDLVIEQAYRDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDXXXXXXXXXXXXXGTFXXXXXXXXXXXXXXNNLSTCASKCIGXXXXXXXXXXXXPCQKSIVAVSDSKKPTLPKCNKPIPISHSTTLCDTKRQGSLSKTCPGNVTVCCDLNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLSNPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTFGYSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNVYNQQNRISGDSGLQEDIE 2543
            MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAAR+IQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVKN+LKKQNSYEDLVIEQAYRDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDASSMSMTPSPTAPGTFSI              LS+  S  I  +  ++      PCQKSIVAVSDSKKPTLPKCNKPIPISHSTTLCDT+RQGSLSKTCPGNVTVCCDLNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLSNPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTF YSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNVYNQQNRISGDSGLQEDIE
Sbjct:    1 MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSEDLREKEIEFTERRFGGRYKSHQAARIIQSSYREYQLRKDYKKLKLEKRVSRRLDLPSINTHNNSSYNSPTIHATTQSILESVKNDLKKQNSYEDLVIEQAYRDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDASSMSMTPSPTAPGTFSI--------------LSSSPSLVISKTIINSSS----PCQKSIVAVSDSKKPTLPKCNKPIPISHSTTLCDTRRQGSLSKTCPGNVTVCCDLNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLSNPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTFVYSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNVYNQQNRISGDSGLQEDIE 800

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST
Match: SMESG000042180.1 (SMESG000042180.1)

HSP 1 Score: 313.153 bits (801), Expect = 5.173e-93
Identity = 160/345 (46.38%), Postives = 232/345 (67.25%), Query Frame = 3

Query: 1209 KRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQ--QFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL--RRDDEILATFNTRTASDRKRFVEDLIETVSEVSEMDRLRIEEEL 2231
            KR+YR+ LN+FN+N + G++YLI+ +F++P P+ +AKFL+++ GISR ++GDY+G   D LA +  K+F+R ++M+NKE+D ALR  + +  +PGESQKI  +MEEF+E+Y+ QN   QF     K+ DTIM+LAYAIIML TD +N +I+K  KM+ E+F++NLR VD+  DI+ NIL  IY R+   E+KT  DHTDQVR+++    G  +P +L    RR +CYCRL E++D  KK++  AHQREVFLFNDLL+ITK   K +K+   YQCR  + L  +++  F    Y FGI L  R+ +E +   N     D+K+F  DL + + E  EM ++   E L
Sbjct:  369 KRMYRVGLNLFNRNPVVGINYLIKNQFIKPHPSHIAKFLLTKNGISRNAVGDYIGLLNDPLALQVTKYFLRRINMKNKEVDEALRSFIYYVHLPGESQKISHLMEEFKETYVHQNDRSQF-----KSLDTIMVLAYAIIMLQTDAHNLSIKKNEKMTLEQFVNNLRGVDENNDIDRNILEPIYMRVTGKELKTMPDHTDQVRRLNDIICGPNKPADLVNRVRRFMCYCRLSEIVDDNKKNKPAAHQREVFLFNDLLMITKLQNKSRKED-QYQCRYALPLVDLQVKQFRMTNYEFGIHLMKRKANESIIKLNALCQLDQKKFFFDLSDCIFESLEMSKINQSESL 707

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST
Match: SMESG000081851.1 (SMESG000081851.1)

HSP 1 Score: 185.267 bits (469), Expect = 2.375e-50
Identity = 110/301 (36.54%), Postives = 175/301 (58.14%), Query Frame = 3

Query: 1197 ERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCRLFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTISLGKVEIYLFETIYYPFGIQL 2099
            ERR  RL  +  NIFN+N  KG+S+LI+   +E  P  + + L++ +GIS F  G+YL    + LA  T   +++ +  ++  I+  LR L S  +IPGESQ + SI+E F + Y+ QN     ++ KN +TI+ILAY I+MLHT ++N    K+ K++KE F+H  + + + + IN + L  +Y+ +K  +M   SD TDQVR I    +G   P++L Q +R+ +C     E+    KK    +H R ++LFNDLL++TK     +K   +Y+ +  ISL  + + LF   YY  G++L
Sbjct:  118 ERR--RLLTLGKNIFNRNCNKGISFLIQHNIIEEDPEFIVR-LLNSEGISVFVKGEYLSQPNNSLAKATKNKYLKKISFQDCSIEKGLRRLFSQVRIPGESQNLVSILEGFSDEYLFQNPHISSKL-KNENTIVILAYGILMLHTGVHNKCAAKKDKLTKESFLHLFKCIYEEEIINNDFLGELYENVKRKKMSVISDITDQVRNIFMSLTGRF-PKDLIQKYRKFICVYSCNEIYQINKKPDSHSHSRVLYLFNDLLLVTK-----EKSKGIYRFKRVISLSGLRVELFSAEYYGHGLRL 408

[Close]

BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST
Match: SMESG000041501.1 (SMESG000041501.1)

HSP 1 Score: 121.324 bits (303), Expect = 1.723e-27
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 3

Query: 1191 ANERRHKRLYRICLNIFNKNSLKGVSYLIRFKFVEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRNKEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYME---QNQQFWPQICKNPDTIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNILTAIYDRIKTAEMK 1778
            A  ++ K L+   +N+FNK  LKG++YL     +  S   +A+FL     + + +IGD+LG   +    E +  FV   +   KE   +LR  LS F++PGE+QKI  +ME+F   Y E    N QF     K+ DT  +LAY+IIML TD+++  I+ +++M KEE+I   R +++  D++   L  IYD I   E+K
Sbjct:  600 ATRKQQKELFENGINLFNKKPLKGLNYLQNQTLLGTSVEDVAEFLHKDDRLDKTAIGDFLGEN-EKYNIEVMYAFVDQFEFTEKEFVASLRDFLSGFRLPGEAQKIDRLMEKFAARYCECNPTNSQF-----KSADTAYVLAYSIIMLTTDLHSSQIKSRNRMRKEEYIKMNRGINESGDLDIEYLGNIYDEIAGNEIK 792

The following BLAST results are available for this feature:

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Yeast
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IQSEC1	1.588e-90	46.43	IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Sym...	[more]
IQSEC1	2.067e-90	46.43	IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Sym...	[more]
IQSEC1	2.481e-90	46.43	IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Sym...	[more]
IQSEC1	2.901e-90	46.43	IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Sym...	[more]
IQSEC1	1.408e-89	46.93	IQ motif and Sec7 domain ArfGEF 1 [Source:HGNC Sym...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
bris-1	2.036e-73	36.91	BRag/Iqsec/Schizo related Arf GEF family member [...	[more]
bris-1	2.801e-73	36.91	BRag/Iqsec/Schizo related Arf GEF family member [...	[more]
bris-1	1.158e-72	36.91	BRag/Iqsec/Schizo related Arf GEF family member [...	[more]
bris-1	4.366e-72	37.33	BRag/Iqsec/Schizo related Arf GEF family member [...	[more]
gbf-1	2.294e-22	29.52	pep chromosome:WBcel235:III:11751320:11773681:-1 g...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
siz	2.586e-97	46.94	gene:FBgn0026179 transcript:FBtr0111038	[more]
siz	3.519e-97	46.94	gene:FBgn0026179 transcript:FBtr0301602	[more]
siz	9.706e-97	47.32	gene:FBgn0026179 transcript:FBtr0078290	[more]
siz	2.890e-96	47.32	gene:FBgn0026179 transcript:FBtr0078289	[more]
step	9.530e-29	36.41	gene:FBgn0086779 transcript:FBtr0085910	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
iqsec1b	2.175e-88	45.81	IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Ac...	[more]
iqsec1b	3.706e-88	45.81	IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Ac...	[more]
IQSEC1	4.171e-88	45.25	IQ motif and Sec7 domain ArfGEF 1a [Source:NCBI ge...	[more]
IQSEC1	8.464e-88	45.25	IQ motif and Sec7 domain ArfGEF 1a [Source:NCBI ge...	[more]
iqsec2a	1.373e-83	42.06	IQ motif and Sec7 domain ArfGEF 2a [Source:ZFIN;Ac...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IQSEC2	2.500e-82	43.01	IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:1...	[more]
IQSEC2	2.815e-82	43.01	IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:1...	[more]
IQSEC2	3.828e-82	42.74	IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:1...	[more]
IQSEC2	4.756e-82	42.74	IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:1...	[more]
IQSEC2	4.861e-82	42.74	IQ motif and Sec7 domain 2 [Source:NCBI gene;Acc:1...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Iqsec1	1.456e-89	45.88	IQ motif and Sec7 domain 1 [Source:MGI Symbol;Acc:...	[more]
Iqsec1	3.045e-89	45.88	IQ motif and Sec7 domain 1 [Source:MGI Symbol;Acc:...	[more]
Iqsec1	4.797e-89	45.88	IQ motif and Sec7 domain 1 [Source:MGI Symbol;Acc:...	[more]
Iqsec2	6.081e-83	41.34	IQ motif and Sec7 domain 2 [Source:MGI Symbol;Acc:...	[more]
Iqsec2	8.563e-82	41.34	IQ motif and Sec7 domain 2 [Source:MGI Symbol;Acc:...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6DN90\|IQEC1_HUMAN	1.191e-89	46.43	IQ motif and SEC7 domain-containing protein 1 OS=H...	[more]
sp\|Q8R0S2\|IQEC1_MOUSE	1.018e-88	45.88	IQ motif and SEC7 domain-containing protein 1 OS=M...	[more]
sp\|Q5DU25\|IQEC2_MOUSE	2.845e-80	41.09	IQ motif and SEC7 domain-containing protein 2 OS=M...	[more]
sp\|Q5JU85\|IQEC2_HUMAN	3.267e-80	43.01	IQ motif and SEC7 domain-containing protein 2 OS=H...	[more]
sp\|Q3TES0\|IQEC3_MOUSE	2.165e-77	44.00	IQ motif and SEC7 domain-containing protein 3 OS=M...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
I1ZIB8	6.561e-143	99.05	IQ motif and Sec7 domain-1 (Fragment) OS=Schmidtea...	[more]
A0A5J4NP14	9.840e-126	54.01	IQ motif and SEC7 domain-containing protein OS=Par...	[more]
A0A183A8K0	5.720e-125	53.07	SEC7 domain-containing protein OS=Echinostoma capr...	[more]
A0A504YVF3	7.861e-125	53.32	IQ motif and SEC7 domain-containing protein 1 OS=F...	[more]
A0A4E0RD19	1.919e-124	53.32	IQ motif and SEC7 domain-containing protein 1 OS=F...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IQSEC1	9.206e-89	45.81	IQ motif and SEC7 domain-containing protein 1-like...	[more]
IQSEC1	1.075e-88	45.81	IQ motif and SEC7 domain-containing protein 1-like...	[more]
IQSEC1	1.129e-88	45.81	IQ motif and SEC7 domain-containing protein 1-like...	[more]
IQSEC1	1.243e-88	45.81	IQ motif and SEC7 domain-containing protein 1-like...	[more]
IQSEC1	1.253e-88	45.81	IQ motif and SEC7 domain-containing protein 1-like...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000007609.1	1.114e-95	45.43	pep scaffold:Pmarinus_7.0:GL477333:80854:108205:-1...	[more]
iqsec1b	3.609e-88	44.18	IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Ac...	[more]
iqsec1b	2.988e-67	48.55	IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Ac...	[more]
iqsec1b	1.144e-66	50.43	IQ motif and Sec7 domain ArfGEF 1b [Source:ZFIN;Ac...	[more]
ENSPMAT00000001471.1	2.000e-34	37.85	pep scaffold:Pmarinus_7.0:GL477283:166775:173339:-...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4


Match Name	E-value	Identity	Description
SEC7	3.278e-27	33.66	Guanine nucleotide exchange factor (GEF) for ADP r...	[more]
GEA1	4.126e-18	30.36	Guanine nucleotide exchange factor for ADP ribosyl...	[more]
GEA2	1.198e-17	31.92	Guanine nucleotide exchange factor for ADP ribosyl...	[more]
SYT1	4.312e-13	28.05	Guanine nucleotide exchange factor (GEF) for Arf p...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO34882	2.651e-66	37.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38004	1.900e-27	34.76	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31538	6.806e-25	32.68	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41902	7.514e-23	32.78	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29395	2.093e-19	43.96	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IQSEC1	1.468e-88	45.33	IQ motif and SEC7 domain-containing protein 1 [Sou...	[more]
iqsec1b	2.753e-88	45.81	IQ motif and Sec7 domain ArfGEF 1 [Source:NCBI gen...	[more]
iqsec1b	3.319e-88	45.81	IQ motif and Sec7 domain ArfGEF 1 [Source:NCBI gen...	[more]
IQSEC1	3.356e-88	45.33	IQ motif and SEC7 domain-containing protein 1 [Sou...	[more]
IQSEC1	4.298e-88	45.81	IQ motif and SEC7 domain-containing protein 1 [Sou...	[more]

BLAST of IQ motif and Sec7 domain-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000057299.1	0.000e+0	99.51	SMESG000057299.1	[more]
SMESG000057299.1	0.000e+0	95.60	SMESG000057299.1	[more]
SMESG000042180.1	5.173e-93	46.38	SMESG000042180.1	[more]
SMESG000081851.1	2.375e-50	36.54	SMESG000081851.1	[more]
SMESG000041501.1	1.723e-27	36.18	SMESG000041501.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30033566
GenBank	AFJ24772.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033566 ID=SMED30033566|Name=IQ motif and Sec7 domain-1|organism=Schmidtea mediterranea sexual|type=transcript|length=2940bp
TCTATATAAATCTTATATGATATTGTGAGATATGTAATGTTTAAAACATT
TATTTCAATCTTTAATTTTTATAAAATATCCGCTAAATTATGAACAATGA
TGGAATTAAGAGACGATCAGAACTGCGTCGTTCTTCTGCAGTTGATACGC
ATCAATTTCAAGTAAATTGCATCAATGTTTCTTACGATAATCAAAGGTCA
CAAAGACCTTTAACTGTGAGTTATGAATTGAGCGAAGATTTGCGAGAAAA
AGAAATAGAATTTACTGAACGTCGATTTGGAGGAAGATACAAATCTCATC
AAGCAGCAAGAGTAATTCAAAGTTCTTATCGAGAATATCAGTTGCGTAAA
GATTATAAAAAACTCAAACTTGAAAAACGAGTATCTCGTCGATTGGATCT
ACCATCGATAAACACTCACAATAATTCATCTTATAATTCGCCAACAATTC
ACGCTACAACTCAATCGATATTGGAGTCAGTGAAGAATAATTTAAAAAAA
CAAAACAGTTACGAAGATTTGGTGATTGAACAGGCATACAGAGATTGGGA
TAGAGATATTTCTCAAGATTTAATTGATGCAAATACGAAAACCATTGAAC
CAAAGTGTGTAACTAACGATGAACATAAATCCGCAATTAACGACAGTGGA
GAAGAATCAGTTGATGCGTCGTCAATGTCCATGACTCCTTCTCCAACTGC
TCCAGGAACCTTTTCCATTTTATCTTCTAGTCCTTCATTAGTCATATCAA
AAAGTAACAATCTCTCTACTTGTGCTTCCAAATGCATAGGTTCATCATCG
AATTCAGCAATCATTAATTCAAGCTCTCCTTGTCAGAAGTCGATTGTTGC
CGTATCGGATTCAAAGAAGCCAACACTACCGAAGTGCAATAAGCCCATTC
CAATTTCCCACAGTACTACGCTCTGTGATACCAAGCGTCAGGGATCTCTA
TCAAAAACGTGCCCGGGAAATGTGACGGTTTGTTGTGACCTAAATAATTC
GTTCCATGCAGCATCAACATCTCCAAAATACAAGAACGAATTCGGTTGTT
GTTCTCGTTCGAACATCTACAGTCCGATGTATCAGTGTAATTCGGGATCG
AAGCAATTCTCACCGAATTCTCTCGCCGGCTATTTGTCGAATCCCCGATT
GATCGGTGGCAAATTCCAGAAATCTTGCTATTGTCAGGCAGCCAACGAGA
GACGTCATAAACGATTGTATAGGATTTGTCTCAATATTTTCAACAAAAAC
TCATTGAAAGGTGTATCGTATTTAATTCGTTTCAAATTCGTCGAACCGTC
TCCAAATATCTTAGCGAAATTCTTAATGTCTCGTAAAGGTATTAGTAGAT
TTAGTATTGGGGATTATTTAGGTCATACCAAAGATGATCTTGCAACCGAA
ACTCTGAAATTCTTTGTCCGAATGGTCGATATGAGAAATAAAGAAATAGA
TATCGCCCTTAGGCATTTACTGTCTTTTTTCCAAATTCCGGGAGAATCTC
AAAAAATCAAAAGTATCATGGAAGAATTCCAAGAATCTTACATGGAGCAA
AATCAGCAATTTTGGCCTCAAATCTGTAAAAATCCTGACACCATCATGAT
ATTAGCCTATGCGATTATTATGCTGCATACAGATATGTATAATCCTAATA
TTCGAAAGCAACATAAGATGTCAAAAGAAGAATTTATACATAATCTCAGG
AATGTCGACGATGGTCAAGATATTAATCCAAATATACTTACGGCCATCTA
CGACAGAATTAAAACAGCTGAAATGAAAACGTTCTCTGATCATACAGACC
AAGTGCGTAAGATTGACCAACATTTCAGTGGGCATTTGCGTCCAAGAAAC
CTTAATCAGCCTCACAGACGCTTGGTGTGTTACTGTAGATTATTTGAGGT
GATCGATTGTTATAAAAAAGATAGAATCGGTGCTCATCAACGAGAAGTTT
TTCTTTTTAACGATCTTTTGGTTATAACCAAGGGAGTTCAAAAACGCAAA
AAGGATGGTGTTATGTATCAATGCAGAAATACCATTTCACTTGGAAAAGT
TGAAATTTATTTATTCGAAACAATTTACTATCCATTCGGAATCCAACTGA
GACGTGATGATGAAATATTAGCCACATTTAATACCAGAACAGCGTCAGAC
CGCAAGAGATTTGTTGAAGATCTAATTGAAACAGTTTCTGAAGTTAGTGA
AATGGATAGACTTCGAATTGAGGAGGAATTGTTTAAGCAGCAGAGATCCA
ATGTTTCACCAGGATATAAAGATGAGCATGTAAATTTTCCGGGTCGAAAT
TCACAAGAAGTTGTTAGAAGAAAAGATTTATCAACTTTTGGATATTCGAC
GTCTGTGGATGAGGCTAAATTGTCACCGAGCAAGCATCACCAACGATCAT
CTAGTCATGGAGGCCACATTATTGGTATGAATTCGGATGTTTATTCACCA
AATAAAAATGTTGATATCGATGGGCCTCATTCAAATGTCTATAATCAACA
AAATAGAATCAGTGGAGATAGTGGATTACAGGAAGACATCGAATGAATCC
AATCAAATTCACATTCTCATGCTCAGTATTGACAATTTATACTTTGTATT
TCTAGTTTTAGAGAAAATGTCTGATGTAGTCGGTTCTATTGTTCGCTAAT
GAATCGTTCGGCTATTTCATCAGTCAATGTTTGACTGGTAAATAGATATT
TTTTTTCGCATTTTTTATTTAGTTTTTTTCTGGTTGATAAAAATGTCATT
ATAAAAATTTCATGGCAATGATAATAGAGTGGAAATGTTTCTGTAGAATT
TACAAATTCTGGATTCGCCTGTTGGGTTTTGATGATGGAGTGAATTTCAA
CATTTTTTATTAGTTTTTTTTATCGTGATCTTTATGATATTGATAATTGC
AATAATGATGATTTTGTTGTAGTTATTATTATTATTATTA

protein sequence of SMED30033566-orf-1

>SMED30033566-orf-1 ID=SMED30033566-orf-1|Name=SMED30033566-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=819bp
MNNDGIKRRSELRRSSAVDTHQFQVNCINVSYDNQRSQRPLTVSYELSED
LREKEIEFTERRFGGRYKSHQAARVIQSSYREYQLRKDYKKLKLEKRVSR
RLDLPSINTHNNSSYNSPTIHATTQSILESVKNNLKKQNSYEDLVIEQAY
RDWDRDISQDLIDANTKTIEPKCVTNDEHKSAINDSGEESVDASSMSMTP
SPTAPGTFSILSSSPSLVISKSNNLSTCASKCIGSSSNSAIINSSSPCQK
SIVAVSDSKKPTLPKCNKPIPISHSTTLCDTKRQGSLSKTCPGNVTVCCD
LNNSFHAASTSPKYKNEFGCCSRSNIYSPMYQCNSGSKQFSPNSLAGYLS
NPRLIGGKFQKSCYCQAANERRHKRLYRICLNIFNKNSLKGVSYLIRFKF
VEPSPNILAKFLMSRKGISRFSIGDYLGHTKDDLATETLKFFVRMVDMRN
KEIDIALRHLLSFFQIPGESQKIKSIMEEFQESYMEQNQQFWPQICKNPD
TIMILAYAIIMLHTDMYNPNIRKQHKMSKEEFIHNLRNVDDGQDINPNIL
TAIYDRIKTAEMKTFSDHTDQVRKIDQHFSGHLRPRNLNQPHRRLVCYCR
LFEVIDCYKKDRIGAHQREVFLFNDLLVITKGVQKRKKDGVMYQCRNTIS
LGKVEIYLFETIYYPFGIQLRRDDEILATFNTRTASDRKRFVEDLIETVS
EVSEMDRLRIEEELFKQQRSNVSPGYKDEHVNFPGRNSQEVVRRKDLSTF
GYSTSVDEAKLSPSKHHQRSSSHGGHIIGMNSDVYSPNKNVDIDGPHSNV
YNQQNRISGDSGLQEDIE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal
PLANA:0000418	head
PLANA:0002056	medial muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR033742	IQSEC_PH
IPR035999	Sec7_dom_sf
IPR000904	Sec7_dom
IPR001849	PH_domain
IPR023394	Sec7_C_sf
IPR011993	PH-like_dom_sf
IPR000048	IQ_motif_EF-hand-BS

Vocabulary: **molecular function**
Term	Definition
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0032012	regulation of ARF protein signal transduction
GO:0043547	positive regulation of GTPase activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000904	Sec7 domain	SMART	SM00222	sec7_5	coord: 370..562 e-value: 2.2E-51 score: 186.7
IPR000904	Sec7 domain	PFAM	PF01369	Sec7	coord: 374..561 e-value: 1.3E-52 score: 178.1
IPR000904	Sec7 domain	PROSITE	PS50190	SEC7	coord: 366..560 score: 33.206
IPR000904	Sec7 domain	CDD	cd00171	Sec7	coord: 373..562 e-value: 8.79373E-54 score: 182.422
IPR023394	Sec7, C-terminal domain superfamily	GENE3D	G3DSA:1.10.1000.11		coord: 448..566 e-value: 2.1E-38 score: 132.7
IPR033742	IQ motif and SEC7 domain-containing protein, PH domain	PFAM	PF16453	IQ_SEC7_PH	coord: 587..717 e-value: 2.6E-48 score: 163.5
IPR011993	PH-like domain superfamily	GENE3D	G3DSA:2.30.29.30		coord: 585..718 e-value: 4.8E-47 score: 161.2
None	No IPR available	GENE3D	G3DSA:1.10.220.20		coord: 357..447 e-value: 9.7E-19 score: 68.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 758..777
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 799..818
None	No IPR available	PANTHER	PTHR10663	GUANYL-NUCLEOTIDE EXCHANGE FACTOR	coord: 18..764
None	No IPR available	PANTHER	PTHR10663:SF342	FI21420P1	coord: 18..764
None	No IPR available	SUPERFAMILY	SSF50729	PH domain-like	coord: 586..706
IPR000048	IQ motif, EF-hand binding site	PROSITE	PS50096	IQ	coord: 69..97 score: 8.444
IPR035999	Sec7 domain superfamily	SUPERFAMILY	SSF48425	Sec7 domain	coord: 371..571