Protein kinase

Overview


Name	Protein kinase
Smed ID	SMED30033533
Length (bp)	1855

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein kinase (SMED30033533) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase (SMED30033533) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase (SMED30033533) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase (SMED30033533) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033533

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
posterior side	SMED30033533	h1SMcG0008462	dd_Smed_v4_5742_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30033533	h1SMcG0008462	dd_Smed_v4_5742_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30033533	h1SMcG0006046	Contig3808	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30033533	h1SMcG0008462	Contig3808	GPL15192	PMID:29674431 Fincher et al., 2018
oocyte	SMED30033533	h1SMcG0008462	Contig33666	newmark_ests	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30033533	h1SMcG0008462	Contig33666	newmark_ests	PMID:28434803 Rouhana et al., 2017
epidermis	SMED30033533	h1SMcG0008462	dd_Smed_v4_5742_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Protein kinase vs. Ensembl Human
Match: MAP2K2 (mitogen-activated protein kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6842])

HSP 1 Score: 342.813 bits (878), Expect = 4.816e-112
Identity = 182/325 (56.00%), Postives = 231/325 (71.08%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQK+ L  F   K ++G++  +D   + ELG GNGGVV KV+H+PS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYMAPERL G  Y+  SD+WS+GLSL ELA G YPIPP   ++  + F   +   E    H ++       + +       +  MAIFELL YIV+ PPP LP+  F+ +F  F+N CL K P++R  L+ML  H FI
Sbjct:   45 ELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI 369

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BLAST of Protein kinase vs. Ensembl Human
Match: MAP2K1 (mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840])

HSP 1 Score: 340.502 bits (872), Expect = 2.724e-111
Identity = 189/361 (52.35%), Postives = 241/361 (66.76%), Query Frame = 1

Query:  436 PISASSSIYLNRPVSDCTNRNSNYS-----ENVATNIHEITV--QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFID-HLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P    + I LN P  D +  N   S     E +   + E+ +  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +  +        G  L +     + PMAIFELL YIV+ PPP LP   FS  F  F+N CL K P++R  L+ L  H FI
Sbjct:    2 PKKKPTPIQLN-PAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361

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BLAST of Protein kinase vs. Ensembl Human
Match: MAP2K2 (mitogen-activated protein kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6842])

HSP 1 Score: 323.939 bits (829), Expect = 5.016e-106
Identity = 158/277 (57.04%), Postives = 198/277 (71.48%), Query Frame = 1

Query:  694 MARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSI 1509
            MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYMAPERL G  Y+  SD+WS+GLSL ELA G YPIPP   ++  + F   +   E    H ++       + +       +  MAIFELL YIV+ PPP LP+  F+ +F  F+N CL K P++R  L+ML  H FI    +
Sbjct:    1 MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEV 277

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BLAST of Protein kinase vs. Ensembl Human
Match: AC011005.1 (novel protein similar to mitogen-activated protein kinase kinase 2 MAP2K2)

HSP 1 Score: 321.627 bits (823), Expect = 8.089e-104
Identity = 183/348 (52.59%), Postives = 237/348 (68.10%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGT--KLQAIQASEKGP-MAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTS-EIKREYKSTSKS 1560
            E+  QQK+ L  F   K ++G++  +D     EL  GNGGVV KV+H+PS  IMARK IHLEIKPAIR QI+RE QVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD  LK+A R PE I+  ++ +VLRGL YLR+   I+HR+VKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYMAPERL G  Y+  S +WS+ LSL ELA   YPIPP   ++  + F   +   E    H +++  G+  +  +    +  P MAIFELL YIV  PPP LP+  F+ +F  F+N CL K P++R  L+ML  H FI      +L++ + K    +TS S
Sbjct:   45 ELDEQQKR-LEAFLTQKAKVGELKDDDFERTSELDAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIREHQVLHECNSPYIVGFYGAFYCDREISICMEHMDGGSLDQGLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRNVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSVIWSMDLSLVELAIERYPIPPPDAKELEAIFGQPVVDREEGEPHSISSWPGSPGRPNSGYGMDSLPAMAIFELLDYIVKEPPPKLPNGVFTPDFQEFVNKCLIKNPTERADLKMLTNHAFIKRSEACLLSNHQAKHTLMNTSNS 391

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BLAST of Protein kinase vs. Ensembl Human
Match: MAP2K5 (mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6845])

HSP 1 Score: 229.18 bits (583), Expect = 3.638e-68
Identity = 123/272 (45.22%), Postives = 166/272 (61.03%), Query Frame = 1

Query:  679 PSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            PS +I+A K I L+I   ++ QIM EL++L+ C+S YI+G+YG++ VE  ISIC E+MDGGSLD+  K     PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   SDVWSLG+S  ELA G +P P            I KN+                       G +   +LL  IVD   P LP   FS  F+ FI  C++K+P +R + E L  H FI
Sbjct:  151 PSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYP-----------QIQKNQ-----------------------GSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 383

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BLAST of Protein kinase vs. Ensembl Celegans
Match: mek-2 (Dual specificity mitogen-activated protein kinase kinase mek-2 [Source:UniProtKB/Swiss-Prot;Acc:Q10664])

HSP 1 Score: 308.531 bits (789), Expect = 2.429e-99
Identity = 166/320 (51.88%), Postives = 217/320 (67.81%), Query Frame = 1

Query:  538 ITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
            +T  Q Q L  F  +K+ I +++ + + T  ELG GNGGVV K  H+ +  IMARK +HLEIKP++R QI++EL VLH CNSP+IVG+YG++    +ISICMEYMDG SLD++LKK GR PE  V  I+ +V+RGL YL+  + I+HRDVKPSN+LVN  G++KLCDFGVSG LIDSMANSFVGTRSYMAPERLTG  Y   SD+WS GLSL EL  G YP+P     ++ + F++ +NE  +   +   N         S    MAIFE+L YIV+ PPPTLP   F+   + F++ CL+K PS+R +L+ L    F  
Sbjct:   47 LTEPQTQRLSEFLQVKEGIKELSEDMLQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENEIELADSLEEPN-----YHPPSNPASMAIFEMLDYIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLKSLTADVFFT 361

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BLAST of Protein kinase vs. Ensembl Celegans
Match: sek-1 (Dual specificity mitogen-activated protein kinase kinase sek-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EDF7])

HSP 1 Score: 159.458 bits (402), Expect = 1.297e-43
Identity = 117/328 (35.67%), Postives = 174/328 (53.05%), Query Frame = 1

Query:  598 DVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLH--DCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRF----PEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGE---QYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLP-DFCFSSNFLSFINYCLKKEPSDR------LSLEMLEKHKFIAADSIAILTSEI 1530
            ++A  D++ LEELGKG  G+V K++H+ S  IMA K I   I    + Q++ EL      DC  P +V +YG+   E ++ ICME MD  SLD   + A +     PEP +  +  SV+ GL ++++ L++IHRDVKPSNIL+N  G VK+CDFG+SG L +SMA +   G + YM PER+ GE    Y+  +DVWSLG+++ E+A G +P                                      A+ K P   FE L  +V  PPP LP +  FS +   F+  CL+K+ ++R      L++  +E+ +     S+A   +EI
Sbjct:   44 EIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDC-CPQMVRFYGAMFREGDVWICMEVMDT-SLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVGTHPY-------------------------------------ANWKTP---FEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFINEI 329

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Query:  598 DVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLH--DCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRF----PEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGE---QYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLP-DFCFSSNFLSFINYCLKKEPSDR------LSLEMLEKHKFIAADSIAILTSEI 1530
            ++A  D++ LEELGKG  G+V K++H+ S  IMA K I   I    + Q++ EL      DC  P +V +YG+   E ++ ICME MD  SLD   + A +     PEP +  +  SV+ GL ++++ L++IHRDVKPSNIL+N  G VK+CDFG+SG L +SMA +   G + YM PER+ GE    Y+  +DVWSLG+++ E+A G +P                                      A+ K P   FE L  +V  PPP LP +  FS +   F+  CL+K+ ++R      L++  +E+ +     S+A   +EI
Sbjct:   44 EIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDC-CPQMVRFYGAMFREGDVWICMEVMDT-SLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVGTHPY-------------------------------------ANWKTP---FEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFINEI 329

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BLAST of Protein kinase vs. Ensembl Celegans
Match: jkk-1 (Dual specificity mitogen-activated protein kinase kinase jkk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EDT6])

HSP 1 Score: 155.606 bits (392), Expect = 3.052e-41
Identity = 97/279 (34.77%), Postives = 143/279 (51.25%), Query Frame = 1

Query:  688 QIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILK----KAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANS-FVGTRSYMAPERLTGE---QYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPD---FCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKF 1491
            ++MA K ++         +I+R+++++  CNSP+IV  YG +  ++ + ICM+ M      L+ +    K   FPE +  HI  S +  L YL++   IIHRD+KPSNIL +  G+VKLCDFG+SG + DSMA+S   G   YMAPERLT E   +Y+  SDVWSLG+++ +L TG+YP P    E   +  +I  N N                                     P P+L +     FS  F+ F++ CL+K+  +R     L KH F
Sbjct:  144 KLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGLYPFPLNDME--FTTLTIIANLNL------------------------------------PSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDF 384

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BLAST of Protein kinase vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 149.058 bits (375), Expect = 8.847e-38
Identity = 102/291 (35.05%), Postives = 150/291 (51.55%), Query Frame = 1

Query:  688 QIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMAN--SFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA-ADSIAILTSEIKR--EYK 1545
            +++A K I LE        I +E+QVL  C+S Y+  Y+GS+   +++ I MEY+ GGS  L L K+G+  E  +A I   +L+GL YL  +   IHRD+K +N+LV+  GDVK+ DFGV+G+L +++    +FVG+  +MAPE +    Y+  +D+WSLG++  ELA G  P   + P + L  F I KN                                       PPP L    +S  F  F+  CL K+P +R S   L KH+FI  A   +IL   I+R  EY+
Sbjct:   43 RVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSA-LDLTKSGKLDESHIAVILREILKGLEYLH-SERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVL--FLIPKN---------------------------------------PPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYR 290

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BLAST of Protein kinase vs. Ensembl Fly
Match: Dsor1 (gene:FBgn0010269 transcript:FBtr0340120)

HSP 1 Score: 330.872 bits (847), Expect = 8.945e-108
Identity = 180/317 (56.78%), Postives = 229/317 (72.24%), Query Frame = 1

Query:  544 VQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
             ++K+I + F + K++IG+++ ED+  L ELG GNGGVV KV+H  +  IMARK IHLE+KPAI+ QI+REL+VLH+CN P+IVG+YG+++ + EISICMEYMDGGSLDLILK+AGR PE I+  IT +VL+GL YLR    IIHRDVKPSNILVN  G++K+CDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WSLGLSL E+A G+YPIPP       S F+ +          A E+G      +A     MAIFELL YIV+ PPP L    FS+ F  F++ CLKK+P +R  L+ L  H +I
Sbjct:   61 TERKRIKM-FLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADN----------AEESGQPTDEPRA-----MAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI 361

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BLAST of Protein kinase vs. Ensembl Fly
Match: Dsor1 (gene:FBgn0010269 transcript:FBtr0071313)

HSP 1 Score: 330.872 bits (847), Expect = 9.134e-108
Identity = 180/317 (56.78%), Postives = 229/317 (72.24%), Query Frame = 1

Query:  544 VQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
             ++K+I + F + K++IG+++ ED+  L ELG GNGGVV KV+H  +  IMARK IHLE+KPAI+ QI+REL+VLH+CN P+IVG+YG+++ + EISICMEYMDGGSLDLILK+AGR PE I+  IT +VL+GL YLR    IIHRDVKPSNILVN  G++K+CDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WSLGLSL E+A G+YPIPP       S F+ +          A E+G      +A     MAIFELL YIV+ PPP L    FS+ F  F++ CLKK+P +R  L+ L  H +I
Sbjct:   64 TERKRIKM-FLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADN----------AEESGQPTDEPRA-----MAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI 364

[Close]

BLAST of Protein kinase vs. Ensembl Fly
Match: lic (gene:FBgn0261524 transcript:FBtr0073720)

HSP 1 Score: 158.303 bits (399), Expect = 5.198e-43
Identity = 101/281 (35.94%), Postives = 145/281 (51.60%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQV-LHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAG----RFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGE----QYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            ++ ++A K I + +    + +++ +L + +   + PY V +YG+ + E ++ ICME M   SLD    K      R  E ++  I  SV+  L YL   L +IHRDVKPSNIL+N  G VK+CDFG+SG L+DS+A +   G + YMAPER+  +    QY+  SDVWSLG+ + E+ATG YP                  +N+                    + P   FE L  +V+  PP LP+  FS  F  FI  CL+KE   R + E L KH FI
Sbjct:   68 TDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVM-STSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPY-----------------DNW--------------------RTP---FEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI 307

[Close]

BLAST of Protein kinase vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0334320)

HSP 1 Score: 159.073 bits (401), Expect = 1.600e-42
Identity = 108/284 (38.03%), Postives = 149/284 (52.46%), Query Frame = 1

Query:  685 EQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSP-YIVGYYGSYHVETEISICMEYMDGGSLD----LILKKAGR-FPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGEQ---YNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTL----PDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            +++MA K I   +    + Q++ +L+V+   N   YIV +YG+   E +  ICME MD  SLD     I +K  R  PE I+A IT + +  L YL++ L IIHRDVKPSNIL++  GD+KLCDFG+SG+L+DS+A +   G R YMAPER+  E+   Y+  SDVWSLG++L E+ATG +P       K+ S                                   +FE L  +V   PP L        FS  F+ F+N CL K+ SDR     L +  FI
Sbjct:  145 DKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDT-SLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY-----RKWDS-----------------------------------VFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI 387

[Close]

BLAST of Protein kinase vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0081892)

HSP 1 Score: 159.073 bits (401), Expect = 1.600e-42
Identity = 108/284 (38.03%), Postives = 149/284 (52.46%), Query Frame = 1

Query:  685 EQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSP-YIVGYYGSYHVETEISICMEYMDGGSLD----LILKKAGR-FPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGEQ---YNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTL----PDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            +++MA K I   +    + Q++ +L+V+   N   YIV +YG+   E +  ICME MD  SLD     I +K  R  PE I+A IT + +  L YL++ L IIHRDVKPSNIL++  GD+KLCDFG+SG+L+DS+A +   G R YMAPER+  E+   Y+  SDVWSLG++L E+ATG +P       K+ S                                   +FE L  +V   PP L        FS  F+ F+N CL K+ SDR     L +  FI
Sbjct:  145 DKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDT-SLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY-----RKWDS-----------------------------------VFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI 387

[Close]

BLAST of Protein kinase vs. Ensembl Zebrafish
Match: map2k2a (mitogen-activated protein kinase kinase 2a [Source:ZFIN;Acc:ZDB-GENE-041027-1])

HSP 1 Score: 335.88 bits (860), Expect = 1.216e-109
Identity = 181/321 (56.39%), Postives = 227/321 (70.72%), Query Frame = 1

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQ++ L  F   K ++G++  ED   + ELG GNGGVV KV+HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SDVWS+GLSL ELA G YPIPP   ++  + F   +        H M+       + +       +  MAIFELL YIV+ PPP LP   F+++F  F+  CL K P+DR  L+ML  H FI
Sbjct:   46 QQRKRLEAFLTQKAQVGELKDEDFEPICELGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRYPIPPPDAKELEAIFGRPVLDAGGAEGHSMSPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPHGVFTTDFEEFVTKCLIKNPADRADLKMLMGHTFI 366

[Close]

BLAST of Protein kinase vs. Ensembl Zebrafish
Match: map2k2b (mitogen-activated protein kinase kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080219-34])

HSP 1 Score: 335.495 bits (859), Expect = 1.643e-109
Identity = 184/317 (58.04%), Postives = 222/317 (70.03%), Query Frame = 1

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGP-MAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQK+ L  F   K  +G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   IIHRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SDVWS+GLSL ELA G YPIPP   ++    F     +       +T    +      S  GP MAIFELL YIV+ PPP LP   F+ +F  F+  CL K P+DR  L+ML  H FI
Sbjct:   48 QQKKRLEAFLTQKANLGELKDDDFQHICELGAGNGGVVNKVCHKPSGLVMARKLIHLEIKPAIRHQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMENMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIIHRDVKPSNILVNCRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRYPIPPPDAKELEGIFGRALMDVGDSETHSTSPRPRPPGRPISGHGPVMAIFELLDYIVNEPPPKLPHGVFTPDFQDFVTNCLIKNPADRADLKMLMNHTFI 364

[Close]

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGP-MAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQK+ L  F   K  +G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   IIHRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SDVWS+GLSL ELA G YPIPP   ++    F     +       +T    +      S  GP MAIFELL YIV+ PPP LP   F+ +F  F+  CL K P+DR  L+ML  H FI
Sbjct:   48 QQKKRLEAFLTQKANLGELKDDDFQHICELGAGNGGVVNKVCHKPSGLVMARKLIHLEIKPAIRHQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMENMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIIHRDVKPSNILVNCRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRYPIPPPDAKELEGIFGRALMDVGDSETHSTSPRPRPPGRPISGHGPVMAIFELLDYIVNEPPPKLPHGVFTPDFQDFVTNCLIKNPADRADLKMLMNHTFI 364

[Close]

BLAST of Protein kinase vs. Ensembl Zebrafish
Match: map2k1 (mitogen-activated protein kinase kinase 1 [Source:ZFIN;Acc:ZDB-GENE-040426-2759])

HSP 1 Score: 326.635 bits (836), Expect = 4.442e-106
Identity = 178/323 (55.11%), Postives = 226/323 (69.97%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFID-HLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQK+ L  F   K+++G++  +D   + ELG GNGGVV KV H+PS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME MDGGSLD  LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G +PIPP   ++    F   +  + +  D        G    +     + PMAIFELL YIV+ PPP LP   F + F  F+N CL K P++R  L+ L  H FI
Sbjct:   42 ELDEQQKKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVLHRPSGFIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMENMDGGSLDQCLKKAGKIPEQILGKVSIAVIKGLSYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRFPIPPPDAKELEQIFGQPLEGDPSASDTSPKPRPPGRPGSSYGPDSRPPMAIFELLDYIVNEPPPKLPSI-FGAEFQDFVNKCLIKNPAERADLKQLMVHSFI 363

[Close]

BLAST of Protein kinase vs. Ensembl Zebrafish
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:ZFIN;Acc:ZDB-GENE-030131-1517])

HSP 1 Score: 223.016 bits (567), Expect = 1.132e-65
Identity = 119/272 (43.75%), Postives = 163/272 (59.93%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
             ++I+A K I L+I   ++ QIM EL++L+ C+SPYI+ +Y ++ VE  ISIC E+MDGGSLD+      R PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   SDVWS+G+S  ELA G +P P            I KN+                       G +   +LL  IVD  PP LP   FS  F+ FI  C++K P +R +   L  H FI 
Sbjct:  188 GKRIVAVKVIPLDITVELQKQIMSELEILYKCDSPYIIKFYSAFFVENRISICTEFMDGGSLDVYW----RIPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSVGISFMELALGSFPYP-----------QIQKNQ-----------------------GSLMPLQLLQCIVDEDPPVLPVGQFSEKFVHFITQCMRKLPKERPAPNNLMDHPFIV 420

[Close]

BLAST of Protein kinase vs. Ensembl Xenopus
Match: pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Source:Xenbase;Acc:XB-GENE-482674])

HSP 1 Score: 338.961 bits (868), Expect = 1.338e-110
Identity = 178/323 (55.11%), Postives = 228/323 (70.59%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKP+  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +     +A       + I +     + PMAIFELL YIV+ PPP LP   F + F  F+N CL K P++R  L+ L  H FI
Sbjct:   41 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVEGDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCLVKNPAERADLKQLMVHSFI 363

[Close]

BLAST of Protein kinase vs. Ensembl Xenopus
Match: pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Source:Xenbase;Acc:XB-GENE-482674])

HSP 1 Score: 337.806 bits (865), Expect = 2.052e-110
Identity = 178/323 (55.11%), Postives = 228/323 (70.59%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKP+  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +     +A       + I +     + PMAIFELL YIV+ PPP LP   F + F  F+N CL K P++R  L+ L  H FI
Sbjct:   23 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVEGDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCLVKNPAERADLKQLMVHSFI 345

[Close]

BLAST of Protein kinase vs. Ensembl Xenopus
Match: pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Source:Xenbase;Acc:XB-GENE-482674])

HSP 1 Score: 323.553 bits (828), Expect = 5.807e-105
Identity = 170/307 (55.37%), Postives = 218/307 (71.01%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKE 1446
            E+  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKP+  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +     +A       + I +     + PMAIFELL YIV+ PPP LP   F + F  F+N C  K+
Sbjct:   41 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVEGDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCFIKQ 347

[Close]

BLAST of Protein kinase vs. Ensembl Xenopus
Match: pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Source:Xenbase;Acc:XB-GENE-482674])

HSP 1 Score: 318.161 bits (814), Expect = 1.284e-103
Identity = 168/301 (55.81%), Postives = 215/301 (71.43%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFIN 1428
            E+  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKP+  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +     +A       + I +     + PMAIFELL YIV+ PPP LP   F + F  F+N
Sbjct:   23 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVEGDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVN 323

[Close]

BLAST of Protein kinase vs. Ensembl Xenopus
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:549042])

HSP 1 Score: 225.328 bits (573), Expect = 2.278e-66
Identity = 123/273 (45.05%), Postives = 164/273 (60.07%), Query Frame = 1

Query:  679 PSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
            PS +I+A K I L+I   ++ QIM EL++L+ C+S YI+G+YG++ VE  ISIC E+MDGGSLD+  K     PE ++  I  +VL+GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER+ GEQY   SDVWSLG+S  ELA G +P P            I KN                        G +   ++L  IVD   P LP   FS +F+ FI  C++K P +R + E L  H FI 
Sbjct:  187 PSGKILAVKVIPLDITVELQRQIMSELEILYKCDSLYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----IPEQVLGRIAVAVLKGLTYLW-SLKILHRDVKPSNMLVNTRGHVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERIAGEQYGIHSDVWSLGISFMELALGRFPYP-----------QIQKNH-----------------------GSLMPLQILQCIVDEECPVLPLGEFSESFVHFITQCMRKPPKERPAPEELMDHPFIV 420

[Close]

BLAST of Protein kinase vs. Ensembl Mouse
Match: Map2k1 (mitogen-activated protein kinase kinase 1 [Source:MGI Symbol;Acc:MGI:1346866])

HSP 1 Score: 343.199 bits (879), Expect = 1.732e-112
Identity = 190/361 (52.63%), Postives = 242/361 (67.04%), Query Frame = 1

Query:  436 PISASSSIYLNRPVSDCTNRNSNYS-----ENVATNIHEITV--QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFID-HLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P    + I LN P  D +  N   S     E +   + E+ +  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F  H   +  +        G  L +     + PMAIFELL YIV+ PPP LP   FS  F  F+N CL K P++R  L+ L  H FI
Sbjct:    2 PKKKPTPIQLN-PAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361

[Close]

BLAST of Protein kinase vs. Ensembl Mouse
Match: Map2k2 (mitogen-activated protein kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346867])

HSP 1 Score: 339.732 bits (870), Expect = 5.791e-111
Identity = 178/321 (55.45%), Postives = 229/321 (71.34%), Query Frame = 1

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQ++ L  F   K ++G++  +D   + ELG GNGGVV K +H+PS  IMARK IHLEIKPA+R QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL ELA G YPIPP   ++  ++F   +    +   H ++       + I       +  MAIFELL YIV+ PPP LP   FSS+F  F+N CL K P++R  L++L  H FI
Sbjct:   49 QQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI 369

[Close]

BLAST of Protein kinase vs. Ensembl Mouse
Match: Map2k2 (mitogen-activated protein kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346867])

HSP 1 Score: 338.961 bits (868), Expect = 9.602e-111
Identity = 178/322 (55.28%), Postives = 229/322 (71.12%), Query Frame = 1

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGTKLQAIQASE----KGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQ++ L  F   K ++G++  +D   + ELG GNGGVV K +H+PS  IMARK IHLEIKPA+R QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL ELA G YPIPP   ++  ++F   +    +   H ++       + I        +  MAIFELL YIV+ PPP LP   FSS+F  F+N CL K P++R  L++L  H FI
Sbjct:   49 QQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI 370

[Close]

BLAST of Protein kinase vs. Ensembl Mouse
Match: Map2k5 (mitogen-activated protein kinase kinase 5 [Source:MGI Symbol;Acc:MGI:1346345])

HSP 1 Score: 228.024 bits (580), Expect = 1.650e-67
Identity = 123/273 (45.05%), Postives = 166/273 (60.81%), Query Frame = 1

Query:  679 PSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
            PS +I+A K I L+I   ++ QIM EL++L+ C+S YI+G+YG++ VE  ISIC E+MDGGSLD+  K     PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   SDVWSLG+S  ELA G +P P            I KN+                       G +   +LL  IVD   P LP   FS  F+ FI  C++K+P +R + E L  H FI 
Sbjct:  187 PSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----IPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYP-----------QIQKNQ-----------------------GSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420

[Close]

BLAST of Protein kinase vs. Ensembl Mouse
Match: Map2k3 (mitogen-activated protein kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346868])

HSP 1 Score: 167.548 bits (423), Expect = 4.229e-46
Identity = 115/316 (36.39%), Postives = 165/316 (52.22%), Query Frame = 1

Query:  592 IGDVAFE----DIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQV-LHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDL----ILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGE----QYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
            IGD  FE    D++T+ ELG+G  GVV KV+H  S  IMA K I   +    + +++ +L + +   +  Y V +YG+   E ++ ICME MD  SLD     +L+K  + PE I+  I  S++R L +L   L +IHRDVKPSN+L+N EG VK+CDFG+SG L+DS+A +   G + YMAPER+  E     YN  SDVWSLG+++ E+A   +P    G                                          F+ L  +V+ P P LP   FS  F+ F + CL+K P++R+S   L +H F  
Sbjct:   52 IGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWG----------------------------------------TPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFT 326

[Close]

BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|P31938|MP2K1_MOUSE (Dual specificity mitogen-activated protein kinase kinase 1 OS=Mus musculus OX=10090 GN=Map2k1 PE=1 SV=2)

HSP 1 Score: 343.199 bits (879), Expect = 1.211e-111
Identity = 190/361 (52.63%), Postives = 242/361 (67.04%), Query Frame = 1

Query:  436 PISASSSIYLNRPVSDCTNRNSNYS-----ENVATNIHEITV--QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFID-HLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P    + I LN P  D +  N   S     E +   + E+ +  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F  H   +  +        G  L +     + PMAIFELL YIV+ PPP LP   FS  F  F+N CL K P++R  L+ L  H FI
Sbjct:    2 PKKKPTPIQLN-PAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361

[Close]

BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|P36507|MP2K2_HUMAN (Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1)

HSP 1 Score: 342.813 bits (878), Expect = 2.313e-111
Identity = 182/325 (56.00%), Postives = 231/325 (71.08%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFS--IHKNENFIDHLMATENGTKLQAIQA---SEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQK+ L  F   K ++G++  +D   + ELG GNGGVV KV+H+PS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYMAPERL G  Y+  SD+WS+GLSL ELA G YPIPP   ++  + F   +   E    H ++       + +       +  MAIFELL YIV+ PPP LP+  F+ +F  F+N CL K P++R  L+ML  H FI
Sbjct:   45 ELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI 369

[Close]

BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|Q91447|MP2K1_SERCA (Dual specificity mitogen-activated protein kinase kinase 1 (Fragment) OS=Serinus canaria OX=9135 GN=MAP2K1 PE=2 SV=1)

HSP 1 Score: 342.043 bits (876), Expect = 3.591e-111
Identity = 180/323 (55.73%), Postives = 232/323 (71.83%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIH-KNENFIDHLMATEN--GTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKPS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F    + ++ +      +   G  + +  +  + PMAIFELL YIV+ PPP LP+  F S F  F+N CL K P++R  L+ L  H FI
Sbjct:   34 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPVEGDSPVTETSPRQRAPGRPMSSYGSDSRPPMAIFELLDYIVNEPPPKLPNGVFGSEFQDFVNKCLIKNPAERADLKQLMIHAFI 356

[Close]

BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|P29678|MP2K1_RABIT (Dual specificity mitogen-activated protein kinase kinase 1 OS=Oryctolagus cuniculus OX=9986 GN=MAP2K1 PE=1 SV=2)

HSP 1 Score: 340.887 bits (873), Expect = 1.125e-110
Identity = 189/361 (52.35%), Postives = 241/361 (66.76%), Query Frame = 1

Query:  436 PISASSSIYLNRPVSDCTNRNSNYS-----ENVATNIHEITV--QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFID-HLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P    + I LN P  D +  N   S     E +   + E+ +  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +  +        G  L +     + PMAIFELL YIV+ PPP LP   FS  F  F+N CL K P++R  L+ L  H FI
Sbjct:    2 PKKKPTPIQLN-PAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361

[Close]

BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|Q02750|MP2K1_HUMAN (Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2)

HSP 1 Score: 340.502 bits (872), Expect = 1.308e-110
Identity = 189/361 (52.35%), Postives = 241/361 (66.76%), Query Frame = 1

Query:  436 PISASSSIYLNRPVSDCTNRNSNYS-----ENVATNIHEITV--QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFID-HLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P    + I LN P  D +  N   S     E +   + E+ +  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F      +  +        G  L +     + PMAIFELL YIV+ PPP LP   FS  F  F+N CL K P++R  L+ L  H FI
Sbjct:    2 PKKKPTPIQLN-PAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361

[Close]

BLAST of Protein kinase vs. TrEMBL
Match: A0A193PD23 (MAPK/ERK kinase 1/2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 736.487 bits (1900), Expect = 0.000e+0
Identity = 381/476 (80.04%), Postives = 419/476 (88.03%), Query Frame = 1

Query:  178 MSQRSPKNHLNLMLPSKDTCKGIEISETASNNIRNKESPKSDSHESNNFEIPSIVQDVFPRSDAIETDCAQSNECLTELINNVYLTPISASSSIYLNRPVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKSTSKSHELFVGQYVQKIMLL 1605
            M+Q+S KNHLNLMLPS++    +E       N+ ++++ K ++ E N  +IPSI+QD  P+SD +E D  Q NE  + LINNVYL P S SSS+YLNR +++C NR+ N SE    NI EI+++Q+QILLNFQ +KK+IGDV  +DIITLEELGKGNGGVV KVKHKPS QIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYM+GGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPV PEKFLSAFSIHK+ENFIDHL ATENGTKLQAIQ SEKG MAIFELLSYIVDYPPPTLP+FCFSSNFLSFINYCLKKEP+DRLSLEMLEKHKFIAADSIAIL SEI ++Y   SKS E+ VG+Y+QKIMLL
Sbjct:    1 MTQKSLKNHLNLMLPSQEAKTDMEFRGKTICNLNHEDNSKIENLELNQLDIPSIIQDNIPKSDLVENDI-QLNE--SYLINNVYLAPNSVSSSLYLNRVLNECVNRDFNSSEIKLQNIQEISLRQQQILLNFQKLKKKIGDVLSDDIITLEELGKGNGGVVTKVKHKPSCQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMNGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVSPEKFLSAFSIHKSENFIDHLRATENGTKLQAIQTSEKGSMAIFELLSYIVDYPPPTLPEFCFSSNFLSFINYCLKKEPNDRLSLEMLEKHKFIAADSIAILISEINKDY-VFSKSSEILVGRYIQKIMLL 472

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BLAST of Protein kinase vs. TrEMBL
Match: A0A430QH14 (Mitogen-activated protein kinase kinase 1 OS=Schistosoma bovis OX=6184 GN=DC041_0000407 PE=4 SV=1)

HSP 1 Score: 426.402 bits (1095), Expect = 1.983e-139
Identity = 220/357 (61.62%), Postives = 272/357 (76.19%), Query Frame = 1

Query:  487 TNRNSNYSENVATNIHEITVQ-----QKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEK-FLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKRE 1539
            +NR S    +VA  + ++ +Q     Q++ L  F   K++IG++  ED   L ELGKGNGGVV++V+H  +  IMA+KNIHLEIKP ++TQI+RELQVLHDCNSPYIVGYYG++  + +IS+CMEYMDGGSLD++L  AGR PEPIVA I  SV+RGL+YLR+ LHIIHRDVKPSNILVN  GDVKLCDFGVSG+LIDS+ANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSL ELATG YPIP +  E  +LSAFS H++ N   HL A + G  L A+ +   GPMAIFELLSYIVD PPP LP FCFS +F+  ++ CL++  SDR SLE L KH+F+   + A  +  ++R+
Sbjct:  145 SNRISTGPVDVAEVLKQLAIQDLDDNQRRRLSAFVADKQKIGELHPEDFEKLNELGKGNGGVVSRVRHTTTGLIMAKKNIHLEIKPIVKTQIIRELQVLHDCNSPYIVGYYGAFFADGDISLCMEYMDGGSLDIVLLHAGRLPEPIVAKILYSVIRGLVYLREVLHIIHRDVKPSNILVNRTGDVKLCDFGVSGQLIDSLANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLVELATGRYPIPAIEDENVYLSAFSSHRDVNLEQHLEAAKEGKPLPAVNSPSSGPMAIFELLSYIVDQPPPRLPKFCFSDDFIDLVDSCLRRPASDRPSLENLLKHRFVVTAAGACPSGNVQRQ 501

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BLAST of Protein kinase vs. TrEMBL
Match: A0A094ZYV9 (Protein kinase domain-containing protein (Fragment) OS=Schistosoma haematobium OX=6185 GN=MS3_08613 PE=3 SV=1)

HSP 1 Score: 420.239 bits (1079), Expect = 2.787e-139
Identity = 215/338 (63.61%), Postives = 263/338 (77.81%), Query Frame = 1

Query:  529 IHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEK-FLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKRE 1539
            I ++   Q++ L  F   K++IG++  ED   L ELGKGNGGVV++V+H  +  IMA+KNIHLEIKP ++TQI+RELQVLHDCNSPYIVGYYG++  + +IS+CMEYMDGGSLD++L  AGR PEPIVA I  SV+RGL+YLR+ LHIIHRDVKPSNILVN  GDVKLCDFGVSG+LIDS+ANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSL ELATG YPIP +  E  +LSAFS H++ N   HL A + G  L A+ +   GPMAIFELLSYIVD PPP LP FCFS +F+  ++ CL++  SDR SLE L KH+F+   + A  +  ++R+
Sbjct:    6 IQDLDDNQRRRLSAFVADKQKIGELHPEDFEKLNELGKGNGGVVSRVRHTTTGLIMAKKNIHLEIKPIVKTQIIRELQVLHDCNSPYIVGYYGAFFADGDISLCMEYMDGGSLDIVLLHAGRLPEPIVAKILYSVIRGLVYLREVLHIIHRDVKPSNILVNRTGDVKLCDFGVSGQLIDSLANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLVELATGRYPIPAIEDENVYLSAFSSHRDVNLEQHLEAAKEGKPLPAVNSPSSGPMAIFELLSYIVDQPPPCLPKFCFSDDFIDLVDSCLRRPASDRPSLENLLKHRFVVTAAGACPSGNVQRQ 343

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BLAST of Protein kinase vs. TrEMBL
Match: A0A3Q0KDI9 (Protein kinase OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 425.631 bits (1093), Expect = 4.664e-139
Identity = 220/357 (61.62%), Postives = 272/357 (76.19%), Query Frame = 1

Query:  487 TNRNSNYSENVATNIHEITVQ-----QKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEK-FLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKRE 1539
            +NR S    +VA  + ++ +Q     Q++ L  F   K++IG++  ED   L ELGKGNGGVV++V+H  +  IMA+KNIHLEIKP ++TQI+RELQVLHDCNSPYIVGYYG++  + +IS+CMEYMDGGSLD++L  AGR PEPIVA I  SV+RGL+YLR+ LHIIHRDVKPSNILVN  GDVKLCDFGVSG+LIDS+ANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSL ELATG YPIP +  EK +LSAFS  ++ N   HL A + G  L A+ +   GPMAIFELLSYIVD PPP LP FCFS +F+  ++ CL++  SDR SLE L KH+F+   + A  +  ++R+
Sbjct:  143 SNRISTGPVDVAEVLKQLAIQDLDDNQRRRLSAFVADKQKIGELHPEDFEKLNELGKGNGGVVSRVRHTTTGLIMAKKNIHLEIKPIVKTQIIRELQVLHDCNSPYIVGYYGAFFADGDISLCMEYMDGGSLDIVLLHAGRLPEPIVAKILYSVIRGLVYLREVLHIIHRDVKPSNILVNRTGDVKLCDFGVSGQLIDSLANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLVELATGRYPIPAIEDEKVYLSAFSSQRDVNLEQHLEAAKEGKPLPAVNSPSSGPMAIFELLSYIVDQPPPRLPKFCFSDDFIDLVDSCLRRPASDRPSLENLLKHRFVVTAAGACPSGNVQRQ 499

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BLAST of Protein kinase vs. TrEMBL
Match: G4VT52 (Protein kinase OS=Schistosoma mansoni OX=6183 GN=Smp_026510 PE=4 SV=1)

HSP 1 Score: 423.705 bits (1088), Expect = 2.658e-138
Identity = 215/339 (63.42%), Postives = 264/339 (77.88%), Query Frame = 1

Query:  526 NIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEK-FLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKRE 1539
            +I ++   Q++ L  F   K++IG++  ED   L ELGKGNGGVV++V+H  +  IMA+KNIHLEIKP ++TQI+RELQVLHDCNSPYIVGYYG++  + +IS+CMEYMDGGSLD++L  AGR PEPIVA I  SV+RGL+YLR+ LHIIHRDVKPSNILVN  GDVKLCDFGVSG+LIDS+ANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSL ELATG YPIP +  EK +LSAFS  ++ N   HL A + G  L A+ +   GPMAIFELLSYIVD PPP LP FCFS +F+  ++ CL++  SDR SLE L KH+F+   + A  +  ++R+
Sbjct:  160 SIQDLDDNQRRRLSAFVADKQKIGELHPEDFEKLNELGKGNGGVVSRVRHTTTGLIMAKKNIHLEIKPIVKTQIIRELQVLHDCNSPYIVGYYGAFFADGDISLCMEYMDGGSLDIVLLHAGRLPEPIVAKILYSVIRGLVYLREVLHIIHRDVKPSNILVNRTGDVKLCDFGVSGQLIDSLANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLVELATGRYPIPAIEDEKVYLSAFSSQRDVNLEQHLEAAKEGKPLPAVNSPSSGPMAIFELLSYIVDQPPPRLPKFCFSDDFIDLVDSCLRRPASDRPSLENLLKHRFVVTAAGACPSGNVQRQ 498

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BLAST of Protein kinase vs. Ensembl Cavefish
Match: map2k2b (mitogen-activated protein kinase kinase 2 [Source:NCBI gene;Acc:103030512])

HSP 1 Score: 340.887 bits (873), Expect = 1.147e-111
Identity = 184/317 (58.04%), Postives = 227/317 (71.61%), Query Frame = 1

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGP-MAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQK+ L  F   K ++G++  +D   + ELG GNGGVV KV HKPS  IMARK IHLEIK AIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SDVWS+GLSL EL+ G YPIPP  P++  + F      N     ++T    +      S  GP MAIFELL YIV+ PPP LP   F+++F  F+  CL K P+DR  L+ML  H FI
Sbjct:   48 QQKKRLEAFLTQKAKVGELKDDDFQRICELGAGNGGVVNKVCHKPSGLIMARKLIHLEIKQAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELSIGRYPIPPPDPKELEAIFG-RPLMNMEGETLSTSPRPRPPGRPVSGHGPAMAIFELLDYIVNEPPPKLPHGVFTADFQDFVTKCLIKNPADRADLKMLMNHTFI 363

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BLAST of Protein kinase vs. Ensembl Cavefish
Match: map2k1 (mitogen-activated protein kinase kinase 1 [Source:NCBI gene;Acc:103028644])

HSP 1 Score: 328.946 bits (842), Expect = 5.929e-107
Identity = 177/323 (54.80%), Postives = 227/323 (70.28%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATE---NGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQK+ L  F   K+++G++  +D   + ELG GNGGVV KV H+PS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD  LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G +PIPP   ++    F +    +      + +    G    +     + PMAIFELL YIV+ PPP LP   F + F  F+N CL K P++R  L+ L  H FI
Sbjct:   42 ELDEQQKKRLEAFLTQKQKVGELKDDDFEKICELGAGNGGVVFKVSHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQSLKKAGKIPEQILGKVSIAVIKGLSYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRFPIPPPDAKELEQIFGLPMEGDPSSSEASPKPRPPGRPSSSYGPDSRPPMAIFELLDYIVNEPPPKLPGI-FGTEFQDFVNKCLIKNPAERADLKQLMVHSFI 363

[Close]

BLAST of Protein kinase vs. Ensembl Cavefish
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:103027486])

HSP 1 Score: 213.386 bits (542), Expect = 2.605e-62
Identity = 135/342 (39.47%), Postives = 192/342 (56.14%), Query Frame = 1

Query:  469 RPVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            RPVS  +   S+   N   ++ + + + K+IL N        G +  +DI   E+LG GNGG V K  H   ++++A K I L+I   ++ QIM EL++L+ C+SPYI+ +Y ++ VE  ISIC E+MDGGSLD+      R PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   SDVWS+G+S  E                     I KN+                       G +   +LL  IVD  PP  P   FS  F++FI  C++K+P +R +   L  H FI
Sbjct:  124 RPVSSSSRGPSDPLPN--NSLKKSSAELKKILTN--------GQINEQDIQYQEQLGHGNGGTVYKAYHLLGKRVLAVKVIPLDITAELQKQIMSELEILYKCDSPYIITFYSAFFVENRISICTEFMDGGSLDVYR----RIPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSVGISFME---------------------IQKNQ-----------------------GSLMPLQLLQCIVDEDPPVFPVGQFSDKFVNFITQCMRKQPKERPAPNNLMDHHFI 406

[Close]

BLAST of Protein kinase vs. Ensembl Cavefish
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:103027486])

HSP 1 Score: 209.149 bits (531), Expect = 2.576e-60
Identity = 137/354 (38.70%), Postives = 201/354 (56.78%), Query Frame = 1

Query:  469 RPVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLS--YIVDY----------PPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            RPVS  +   S+   N   ++ + + + K+IL N        G +  +DI   E+LG GNGG V K  H   ++++A K I L+I   ++ QIM EL++L+ C+SPYI+ +Y ++ VE  ISIC E+MDGGSLD+      R PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   SDVWS+G+S  E                     I KN+  +  L   +      ++Q      +++FEL S  Y+V +           PP  P   FS  F++FI  C++K+P +R +   L  H FI
Sbjct:  124 RPVSSSSRGPSDPLPN--NSLKKSSAELKKILTN--------GQINEQDIQYQEQLGHGNGGTVYKAYHLLGKRVLAVKVIPLDITAELQKQIMSELEILYKCDSPYIITFYSAFFVENRISICTEFMDGGSLDVYR----RIPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSVGISFME---------------------IQKNQGSLMPLQLLQCIVDETSVQG-----LSLFELESRLYVVLHCTASNKRGVQDPPVFPVGQFSDKFVNFITQCMRKQPKERPAPNNLMDHHFI 436

[Close]

BLAST of Protein kinase vs. Ensembl Cavefish
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:103027486])

HSP 1 Score: 206.453 bits (524), Expect = 5.956e-60
Identity = 111/274 (40.51%), Postives = 159/274 (58.03%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLS---YIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
             ++++A K I L+I   ++ QIM EL++L+ C+SPYI+ +Y ++ VE  ISIC E+MDGGSLD+      R PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   SDVWS+G+S  E+                                      K + IQ ++   M I  L+    Y V   PP  P   FS  F++FI  C++K+P +R +   L  H FI
Sbjct:  150 GKRVLAVKVIPLDITAELQKQIMSELEILYKCDSPYIITFYSAFFVENRISICTEFMDGGSLDV----YRRIPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSVGISFMEV--------------------------------------KFRKIQKNQGSLMVICFLMEFSLYCVFQDPPVFPVGQFSDKFVNFITQCMRKQPKERPAPNNLMDHHFI 380

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BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004725.1 (pep scaffold:Pmarinus_7.0:GL477683:141377:157028:-1 gene:ENSPMAG00000004255.1 transcript:ENSPMAT00000004725.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 327.02 bits (837), Expect = 5.196e-108
Identity = 176/307 (57.33%), Postives = 217/307 (70.68%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTK---------LQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFIN 1428
            E+  QQK+ L  F   K+++G++  +D   L ELG GNGGVV KV HKPS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLDL+LKKAGR PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G YPIPP   ++    F     E       A +N T            A     + PMAIFELL YIV+ PPP LP   F+ +F  F+N
Sbjct:   19 ELDEQQKKRLEAFLTQKQKVGELKDDDFEKLSELGAGNGGVVTKVLHKPSALIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDLVLKKAGRIPEEILGKVSIAVIKGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPEAKELEGIFGKAVTEG----AEAMQNNTSPRPRPPGRPGSAYNMDARPPMAIFELLDYIVNEPPPKLPCTVFTQDFQDFVN 321

[Close]

BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: map2k4b (mitogen-activated protein kinase kinase 4b [Source:ZFIN;Acc:ZDB-GENE-080721-13])

HSP 1 Score: 164.081 bits (414), Expect = 1.911e-45
Identity = 114/309 (36.89%), Postives = 162/309 (52.43%), Query Frame = 1

Query:  598 DVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILK-----KAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERL----TGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            D   +D+  L E+G+G  G V K++H  S  IMA K I   +    + Q++ +L V+   + PYIV ++G+   E +  ICME M   S D   K          PE I+  IT + ++ L YL++ L IIHRDVKPSNIL++  G++KLCDFG+SG+L+DS+A +   G R YMAPER+    + + Y+  SDVWSLG++L ELATG +P P     K+ S F         D L     G   Q   + E+                        FS++F++F+N CL K+ S R     L KH FI
Sbjct:   61 DFTADDLKDLGEIGRGAYGSVNKMQHNHSAHIMAVKRIRSTVDEKEQKQLLMDLDVVMSSDCPYIVQFFGALFREGDCWICMELM-STSFDKFYKFVYCTSDDVIPEEILGKITLATVKALNYLKENLKIIHRDVKPSNILLDRRGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLIELATGKFPYP-----KWNSVF---------DQLTQVVKGDPPQLSNSEERQ-----------------------FSASFINFVNSCLTKDESRRPKYRELLKHPFI 331

[Close]

BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239])

HSP 1 Score: 158.303 bits (399), Expect = 1.552e-43
Identity = 106/310 (34.19%), Postives = 161/310 (51.94%), Query Frame = 1

Query:  598 DVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQV-LHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDL----ILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGE----QYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
            +V  +D+ ++ ELG+G  GVV +V+H PS  IMA K I   +    + +++ +L + +   + PY V +YG+   E ++ ICME MD  SLD     +++K    PE I+  I+ ++++ L +L   L +IHRDVKPSN+L+N +G VK+CDFG+SG L+DS+A +   G + YMAPER+  E     YN  SD+WSLG+++ ELA   +P    G                                          F+ L  +V+ P P LP   FS  F+ F   CLKK P++R +   L  + F  
Sbjct:   60 EVKADDLESICELGRGAYGVVERVRHTPSGTIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPYTVTFYGALFREGDVWICMELMDT-SLDKFYKKVIEKGLTIPEDILGKISVAIVKALEHLHSKLSVIHRDVKPSNVLINTQGHVKMCDFGISGYLVDSVAKTLDAGCKPYMAPERINPEINQKGYNVKSDIWSLGITMIELAILKFPYESWG----------------------------------------TPFQQLKQVVEEPSPQLPPENFSPEFVDFSTLCLKKNPNERPTYAELMDNTFFG 328

[Close]

BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: map2k7 (mitogen-activated protein kinase kinase 7 [Source:ZFIN;Acc:ZDB-GENE-090312-186])

HSP 1 Score: 152.91 bits (385), Expect = 2.037e-41
Identity = 116/351 (33.05%), Postives = 175/351 (49.86%), Query Frame = 1

Query:  472 PVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVL---HDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANS-FVGTRSYMAPERL-----TGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLP-DFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P S  +   S  S  +   + EI  Q   + L+ +  +  I ++      TL E+G G  G V K+++KP+  I+A K +          +I+ +L V+   HDC  PYIV  +GS+   T++ I ME M   +  L  +  G  PE I+  +T ++++ L YL++   +IHRDVKPSNIL++  G +KLCDFG+SGRL+DS A +   G  +YMAPER+     T   Y+  +DVWSLG+SL ELATG +P            +   K +                            FE+L+ ++   PP LP D  FS +F +F+  CL K+   R     L +H F+
Sbjct:   33 PSSYGSTPRSLESVEIDQKLQEIMNQTGFLTLDGKRYRADISELE-----TLGEMGSGTCGQVWKMRYKPTSHILAVKQMRRSGNKDENKRILMDLDVVLKSHDC--PYIVQCHGSFITNTDVFIAMELMGTCAEKLKKRIQGPIPENILGKMTVAIVKALSYLKEKHGVIHRDVKPSNILLDSRGRIKLCDFGISGRLVDSKAKTRGAGCAAYMAPERIDPPDPTHPDYDIRADVWSLGISLVELATGQFP------------YQNCKTD----------------------------FEVLTKVLQEDPPLLPSDMGFSLDFQAFVKDCLTKDHRKRPKYNKLLEHAFL 336

[Close]

BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 148.673 bits (374), Expect = 2.202e-39
Identity = 108/302 (35.76%), Postives = 157/302 (51.99%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGS-LDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVK--PSNILVNMEGDVKLCDFGVSGRLIDSM--ANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI--AADSIAILTSEIKREYKSTSKSHE 1566
            +++++A K I LE        I +E+ VL  C+SPY+  Y+GSY   T++ I MEY+ GGS LDLI  K G   E  +A I   +L+GL YL  +   IHRD+K   +N+L++ +GDVKL DFGV+G+L D+    N+FVGT  +MAPE +    Y+  +D+WSLG++  ELA G  P   + P + L  F I KN                                        PPTL +  +S  F  F++ CL K+P  R + + L KHKFI  +A   + LT  I R  +  ++ H+
Sbjct:   48 TKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLI--KPGPLEEHQIATILREILKGLDYLH-SERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVL--FLIPKNN---------------------------------------PPTL-EGNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQRSAKKTSYLTELIDRYKRWKAEGHD 304

[Close]

BLAST of Protein kinase vs. Ensembl Yeast
Match: PBS2 (MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003664])

HSP 1 Score: 214.157 bits (544), Expect = 2.072e-61
Identity = 131/307 (42.67%), Postives = 178/307 (57.98%), Query Frame = 1

Query:  601 VAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKA---GRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNM-EGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTG-----EQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            +  +++  L+ELG GN G V+KV HKP+  IMA K + LE+  A   QI+ EL+VLH CNSPYIV +YG++ +E  + +CMEYMDGGSLD I  ++   G   EP +A I  +V+ GL  L++  +IIHRDVKP+NIL +  +G VKLCDFGVSG L+ S+A + +G +SYMAPER+         Y   SD+WSLGLS+ E+A G YP PP               E + +                       IF  LS IVD PPP LP   FSS+   F++ CL+K P  R +   L +H ++
Sbjct:  355 ITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPP---------------ETYDN-----------------------IFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWL 623

[Close]

BLAST of Protein kinase vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061])

HSP 1 Score: 184.111 bits (466), Expect = 9.541e-52
Identity = 114/285 (40.00%), Postives = 155/285 (54.39%), Query Frame = 1

Query:  682 SEQIMARKNIH-LEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVE--TEISICMEYMDGGSLDL----ILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPP-----PTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAA 1500
             +++ A K I+ +   P  + QI RELQ      S YIV YYG +  E  + I I MEYM G SL+     +LK+ GR  E ++  I  SVLRGL YL +   +IHRD+KP NIL+N +G++KLCDFGVSG  ++S+A +F GT  YMAPER+ G+ Y+   DVWSLGL+L E+A G +P            F   K          T+N              +A  ELL+ I+ + P     P L D  +S  F SFI+YCLKK+  +R S   + KH +I  
Sbjct:  236 GKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHER-KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFP------------FESDK---------ITQN--------------VAPIELLTMILTFSPQLKDEPEL-DISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVG 483

[Close]

BLAST of Protein kinase vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 180.644 bits (457), Expect = 1.966e-50
Identity = 114/285 (40.00%), Postives = 152/285 (53.33%), Query Frame = 1

Query:  688 QIMARKNIH-LEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVE--TEISICMEYMDGGSLDLI----LKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEK--GPMAIFELLSYIVDYPPPTLPD-----FCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAA 1500
            +I A K I+ L   P  + QI RELQ      S YIV YYG +  +  + I I MEYM G SLD I    L++ GR  E ++  I  +VLRGL YL +   +IHRD+KP NIL+N  G VKLCDFGVSG  ++S+A +F GT  YMAPER+ G+ Y+  SDVWSLGL++ E+A G +P                                      +SEK    +A FELL +I+ +  P L D       +S +F SFI+YCLKK+  +R S   +  H +I  
Sbjct:  245 KIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPC-------------------------------------SSEKMAANIAPFELLMWILTF-TPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIKG 490

[Close]

BLAST of Protein kinase vs. Ensembl Yeast
Match: STE7 (Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway [Source:SGD;Acc:S000002318])

HSP 1 Score: 175.637 bits (444), Expect = 1.604e-48
Identity = 118/318 (37.11%), Postives = 165/318 (51.89%), Query Frame = 1

Query:  601 VAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIK-PAIRTQIMRELQVLHDCNSPY--IVGYYGSY---HVETEISICMEYMDGGSLDLILK-------------KAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLP-DFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            +  +D++ L ++G GN G V K  H P  +I+A+K I +E     I  Q++REL ++ +   P+  I+ +YG+Y   H+  EI I MEY D GSLD IL              K   F E  ++ I   VL GL +L +   IIHRD+KPSN+L+N +G +KLCDFGVS +LI+S+A++FVGT +YM+PER+ G  Y+   DVWSLGL + EL TG +P                         +   N T           P  I +LL  IV+ P P LP D  +S     F+N C  K   +R S+  L  H  I
Sbjct:  186 IQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNV-KPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFP-------------------------LGGHNDT-----------PDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLI 466

[Close]

BLAST of Protein kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 122.094 bits (305), Expect = 3.208e-29
Identity = 85/259 (32.82%), Postives = 129/259 (49.81%), Query Frame = 1

Query:  745 IMRELQVLHDCNS-PYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALH---IIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDS--MANSFVGTRSYMAPER-LTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAA 1500
            + RE+Q L        I  YYGSY  +T + I ME+  GGSL  +L+  G+  E  +  I    +R L+   K +H   +IHRD+K +N+L+  EG+VKLCDFGV+ ++  +     +  GT  +MAPE  + G  Y+T  D+WSLG++  E+ATG  P                    + D          ++A++A           +  I+   PP L D  +S++   FI  CL ++P +RLS + L K KFI A
Sbjct:   66 VQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLR-PGKIDEKYIGVI----MRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPP--------------------YCD----------VEALRA-----------MQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRA 278

[Close]

BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO45553 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSF4])

HSP 1 Score: 348.206 bits (892), Expect = 2.018e-115
Identity = 190/327 (58.10%), Postives = 234/327 (71.56%), Query Frame = 1

Query:  526 NIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATEN---GTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIA 1497
            N+ EI   Q++ L  F N K++IG+++ +D   + ELG GNGGVV KV HKP+  IMARK IHLE+KPAIRTQI+REL+VLHDCNSPYIVG++G+++ + EISICME+MDGGSLDLILKKAGR PE I+  I+ +VL+GL YLR+   IIHRDVKPSNILVN  G++K+CDFGVSG+LIDSMANSFVGTRSYM+PERL G QY   SD+WS GLSL E+A G YPIPP  P++     S  +  + +   M+      G +  +   +E  PMAIFELL YIV+ PPP LP   FS  F  F+  CL K P  R  L  L  HKFIA
Sbjct:   12 NLDEI---QRRRLEEFLNEKRKIGELSNDDFEKITELGAGNGGVVTKVLHKPTGLIMARKLIHLEVKPAIRTQIIRELKVLHDCNSPYIVGFFGAFYSDGEISICMEHMDGGSLDLILKKAGRIPEDILGKISIAVLKGLCYLREIHQIIHRDVKPSNILVNSRGEIKMCDFGVSGQLIDSMANSFVGTRSYMSPERLQGNQYTIQSDIWSFGLSLVEMAIGRYPIPPPDPQEIEKVLS--REPSSMASPMSVGRLPPGVRPPSGVNNETRPMAIFELLDYIVNEPPPILPGAHFSPEFCEFVQKCLVKNPKQRADLTYLMTHKFIA 333

[Close]

BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO40740 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6F5])

HSP 1 Score: 229.18 bits (583), Expect = 1.514e-68
Identity = 119/271 (43.91%), Postives = 169/271 (62.36%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            + +I+A K I L++ P ++ QI+ E+++   C SPYI+ +YG++ VE  IS+C EYMDGGSLD+     G  PEP++  I  +V++GL YL   L I+HRDVKPSNILVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER+ G++Y+ LS+VWSLG+SL E+A+G +P   V  +  L+++    N  F                       +   ELL  IV   PP LPD  FS  F+ F+  C++K PS RL+ E +  H FI
Sbjct:  175 TRRIIAVKVIPLDVTPEVQRQIISEMEISFQCASPYIIEFYGAFFVENRISMCTEYMDGGSLDMY----GSIPEPVLGRIAVAVVKGLAYL-WGLKIMHRDVKPSNILVNTRGQVKLCDFGVSRQLVNSIATTYVGTNAYMAPERILGDEYSILSEVWSLGVSLLEMASGRFPYLKVSIQ--LASYFFFGNHCF-----------------------LVPIELLQCIVHEAPPRLPDHLFSPVFVDFVAQCMQKSPSTRLTPEAVLDHIFI 415

[Close]

BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO48408 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJN6])

HSP 1 Score: 154.836 bits (390), Expect = 1.667e-42
Identity = 98/290 (33.79%), Postives = 146/290 (50.34%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQV-LHDCNSPYIVGYYGSYHVETEISICMEYMD----------GGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERL----TGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTL---PDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            S   MA K I   +    + Q++ +L V +   N P+IV +YG+   E +  ICME M+           GS++ I+      PE I++ +  +V++ L YL++ L+IIHRDVKPSNIL++  G +KLCDFG+SG L+DS+A +   G + YMAPER+      + Y+  SDVWS G+++ EL+TG++P P                                           ++F+ LS +VD  PP L   P+   S   L+F+N CL KE   R     L  H+FI
Sbjct:   31 SNTFMAVKRIRSTVDQKDQKQLLMDLDVVMRSSNCPFIVRFYGALFTEGDAWICMELMEISFDKCYKLVYGSIEQII------PEEILSKVAYAVVKALDYLKRELNIIHRDVKPSNILLDRNGAIKLCDFGISGHLVDSIAKTRDAGCKPYMAPERIDPSSCRQGYDIRSDVWSFGITMIELSTGVFPYPKWN----------------------------------------SVFDQLSQVVDGDPPQLSNTPEMMRSPELLNFVNICLSKEVEKRPKYNELLNHQFI 274

[Close]

BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO38062 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDX6])

HSP 1 Score: 155.992 bits (393), Expect = 1.814e-42
Identity = 106/309 (34.30%), Postives = 154/309 (49.84%), Query Frame = 1

Query:  598 DVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQV-LHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDL----ILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPERLTGEQ----YNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            D   +D+  + ELG G  G V ++ H P+  +MA K I   +    + +++ +L + +   + PY V +YG+   E ++ ICME M     DL      K   R PE ++  I  SV+  L YL   L +IHRDVKPSNILV+  G+ KLCDFG+SG+L+DS+A +   G + YMAPER+  ++    Y+  SD+WSLG+++ ELATG +P                                         K P   FE L  +V  P P+LP+  FS NF  F+   L K   +R +   L +H FI
Sbjct:   52 DCQADDLQEIRELGHGAYGYVYEMLHVPTSTVMAVKKIRANVNSTEQKRLLMDLDISMRVSDYPYTVHFYGALFREGDVWICMELMKTSLYDLYKQVFSKPDRRIPEEVLGKIAVSVVSALEYLHSNLKVIHRDVKPSNILVDERGNFKLCDFGISGQLVDSLAKTVDAGCKPYMAPERINPDRDMKGYDIRSDIWSLGITMIELATGKFPY-------------------------------------TQWKTP---FEQLKQVVHEPSPSLPEGPFSLNFRDFVTKSLIKNYKERPNYNQLLEHPFI 320

[Close]

BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 150.984 bits (380), Expect = 3.359e-40
Identity = 107/292 (36.64%), Postives = 151/292 (51.71%), Query Frame = 1

Query:  682 SEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGS-LDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSM--ANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI-AADSIAILTSEIKREYK 1545
            + +++A K I LE        I +E+ VL  C+S Y+  Y+GSY   T++ I MEY+ GGS LDL+  KAG   E  +A I   VL+GL YL     + HRD+K +N+L++  GDVKL DFGV+G+L D++   N+FVGT  +MAPE +    Y++ +D+WSLG++  ELA G  P   + P + L  F I KN                                        PP L    FS  F  F++ CL K+P+DR + + L KH+FI  A   A L   I+R  K
Sbjct:   33 TNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLM--KAGNIEEFYIATILREVLKGLDYLHTEKKL-HRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLHPMRVL--FLIPKNN---------------------------------------PPELTG-NFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFIKTAKKNAYLVELIERHKK 279

[Close]

BLAST of Protein kinase vs. Ensembl Medaka
Match: map2k2a (mitogen-activated protein kinase kinase 2 [Source:NCBI gene;Acc:101173453])

HSP 1 Score: 337.035 bits (863), Expect = 4.148e-110
Identity = 182/319 (57.05%), Postives = 226/319 (70.85%), Query Frame = 1

Query:  547 QQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKF--LSAFSIHKNENFIDHLMATE-NGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            QQ++ L  F   K ++G++  ED   + ELG GNGGVV KV+HKPS  +MARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD +LK+A R PE I+  ++ +VLRGL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SDVWS+GLSL ELA G YPIPP   ++   +  F+I        H       G  +       +  MAIFELL YIV+ PPP LP   F+S+F  F+  CL K P++R  L+ML  H FI
Sbjct:   48 QQRKRLEAFLTQKAQVGELKDEDFEPICELGAGNGGVVNKVRHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRYPIPPPDAKELEAIFGFAILDGAEGEPHTQRPRPPGRPVSGHGVDSRPAMAIFELLDYIVNEPPPKLPHGVFTSDFQDFVTKCLIKNPAERADLKMLMSHTFI 366

[Close]

BLAST of Protein kinase vs. Ensembl Medaka
Match: map2k1 (mitogen-activated protein kinase kinase 1 [Source:NCBI gene;Acc:101162677])

HSP 1 Score: 330.487 bits (846), Expect = 1.281e-107
Identity = 178/322 (55.28%), Postives = 226/322 (70.19%), Query Frame = 1

Query:  535 EITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKF--LSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            E+  QQ++ L  F   K+++G++  +D   + ELG GNGGVV KV H+PS  IMARK IHLEIKPAIR QI+RELQVLH+CNSPYIVG+YG+++ + EISICME+MDGGSLD  LKKAG+ PE I+  ++ +V++GL YLR+   I+HRDVKPSNILVN  G++KLCDFGVSG+LIDSMANSFVGTRSYM+PERL G  Y+  SD+WS+GLSL E+A G +PIPP    +   +  F +       +       G    +     + PMAIFELL YIV+ PPP LP   FSS F  F+N CL K P++R  L+ L  H FI
Sbjct:   42 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKICELGAGNGGVVFKVSHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQSLKKAGKIPEQILGKVSIAVIKGLSYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRFPIPPPDSRELEKIFGFPVEGETASSESPKPRPPGRPGSSYGPDSRPPMAIFELLDYIVNEPPPKLPAI-FSSEFQDFVNKCLIKNPAERADLKQLVVHPFI 362

[Close]

BLAST of Protein kinase vs. Ensembl Medaka
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:101169919])

HSP 1 Score: 219.935 bits (559), Expect = 3.324e-65
Identity = 139/342 (40.64%), Postives = 197/342 (57.60%), Query Frame = 1

Query:  472 PVSDCTNRNSNYSENVATN-IHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P SD T+     S+++A N + + + + K+IL N Q I         +DI   E LG GNGG V K  H    +++A K I L+I   ++ QIM EL++L+ C+SPYI+ ++ ++ VE  ISIC E+MDGGSLD+        PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   +DVWS+G+S  ELA G++P P            I KN+                       G +   +LL  IVD  PP LP   FS  F+ FI  C+++ P +R +   L  H FI
Sbjct:   77 PESDSTHA---VSDSIANNSLKKSSAELKKILTNGQQINA-------QDIHYQELLGHGNGGTVYKAYHVLGNRVLAVKVIPLDITVELQKQIMSELEILYKCDSPYIITFFSAFFVENRISICTEFMDGGSLDVY----KTIPELVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHADVWSVGISFMELALGMFPYP-----------QIQKNQ-----------------------GSLIPLQLLQCIVDEDPPVLPVGEFSEMFVHFITLCMQRNPKERPAPNNLMDHPFI 369

[Close]

BLAST of Protein kinase vs. Ensembl Medaka
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:101169919])

HSP 1 Score: 220.32 bits (560), Expect = 8.301e-65
Identity = 139/342 (40.64%), Postives = 197/342 (57.60%), Query Frame = 1

Query:  472 PVSDCTNRNSNYSENVATN-IHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            P SD T+     S+++A N + + + + K+IL N Q I         +DI   E LG GNGG V K  H    +++A K I L+I   ++ QIM EL++L+ C+SPYI+ ++ ++ VE  ISIC E+MDGGSLD+        PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   +DVWS+G+S  ELA G++P P            I KN+                       G +   +LL  IVD  PP LP   FS  F+ FI  C+++ P +R +   L  H FI
Sbjct:  125 PESDSTHA---VSDSIANNSLKKSSAELKKILTNGQQINA-------QDIHYQELLGHGNGGTVYKAYHVLGNRVLAVKVIPLDITVELQKQIMSELEILYKCDSPYIITFFSAFFVENRISICTEFMDGGSLDVY----KTIPELVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHADVWSVGISFMELALGMFPYP-----------QIQKNQ-----------------------GSLIPLQLLQCIVDEDPPVLPVGEFSEMFVHFITLCMQRNPKERPAPNNLMDHPFI 417

[Close]

BLAST of Protein kinase vs. Ensembl Medaka
Match: map2k5 (mitogen-activated protein kinase kinase 5 [Source:NCBI gene;Acc:101169919])

HSP 1 Score: 209.149 bits (531), Expect = 4.371e-61
Identity = 138/332 (41.57%), Postives = 191/332 (57.53%), Query Frame = 1

Query:  472 PVSDCTNRNSNYSENVATN-IHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLS 1464
            P SD T+     S+++A N + + + + K+IL N Q I         +DI   E LG GNGG V K  H    +++A K I L+I   ++ QIM EL++L+ C+SPYI+ ++ ++ VE  ISIC E+MDGGSLD+        PE ++  I  +V++GL YL  +L I+HRDVKPSN+LVN  G VKLCDFGVS +L++S+A ++VGT +YMAPER++GEQY   +DVWS+G+S  ELA G++P P            I KN+                       G +   +LL  IVD  PP LP   FS  F+ FI  C  K  S RLS
Sbjct:   77 PESDSTHA---VSDSIANNSLKKSSAELKKILTNGQQINA-------QDIHYQELLGHGNGGTVYKAYHVLGNRVLAVKVIPLDITVELQKQIMSELEILYKCDSPYIITFFSAFFVENRISICTEFMDGGSLDV----YKTIPELVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHADVWSVGISFMELALGMFPYP-----------QIQKNQ-----------------------GSLIPLQLLQCIVDEDPPVLPVGEFSEMFVHFITLC--KLVSARLS 357

[Close]

BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000004166.1 (SMESG000004166.1)

HSP 1 Score: 947.192 bits (2447), Expect = 0.000e+0
Identity = 475/476 (99.79%), Postives = 476/476 (100.00%), Query Frame = 1

Query:  178 MSQRSPKNHLNLMLPSKDTCKGIEISETASNNIRNKESPKSDSHESNNFEIPSIVQDVFPRSDAIETDCAQSNECLTELINNVYLTPISASSSIYLNRPVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKSTSKSHELFVGQYVQKIMLL 1605
            MSQRSPKNHLNLMLPSKDTCKGIEISETASNNIRNKESPKSDSHESNNFEIPSIVQDVFPRSDAIETDCAQSNECLTELINNVYLTPISASSSIYLNRPVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELGKGNGGVVAKVKHKPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVN+EGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKSTSKSHELFVGQYVQKIMLL
Sbjct:    1 MSQRSPKNHLNLMLPSKDTCKGIEISETASNNIRNKESPKSDSHESNNFEIPSIVQDVFPRSDAIETDCAQSNECLTELINNVYLTPISASSSIYLNRPVSDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITLEELGKGNGGVVAKVKHKPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNIEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKSTSKSHELFVGQYVQKIMLL 476

[Close]

BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000040086.1 (SMESG000040086.1)

HSP 1 Score: 405.601 bits (1041), Expect = 1.774e-136
Identity = 208/337 (61.72%), Postives = 258/337 (76.56%), Query Frame = 1

Query:  550 QKQILLNFQNIKKRIGDVAFEDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKSTSKS 1560
            Q+Q L  F   KK I +++ +D   + ELGKGNGGVV+KV++KP+  IMARKNIHLEIKPA++ QI+RELQVLHDCNSPYIVGY+G++  + +IS CMEYM+ GSLDL++K AGR PEPIVA IT SV+ GL+YLR+ L IIHRDVKPSNILVN EG+VKLCDFGVSG+LIDSMANSFVGTRSYMAPERL GE+YN  SDVWSLGLSL EL+TG YPIPP   E FLS FS  +  N  +HL A   G KL+A+Q S+   MAIFELL+YIVDYPPP +P+FCFS +F++F++ CL++  SDR  LE L  ++ +   +  +  S  K E+ +   S
Sbjct:   74 QRQKLFEFVAKKKNISELSADDFEFIAELGKGNGGVVSKVRYKPTNLIMARKNIHLEIKPAVKAQIIRELQVLHDCNSPYIVGYFGAFFSDGDISFCMEYMNSGSLDLVMKNAGRLPEPIVAKITVSVVNGLLYLREELDIIHRDVKPSNILVNSEGEVKLCDFGVSGQLIDSMANSFVGTRSYMAPERLIGEEYNVRSDVWSLGLSLIELSTGRYPIPPAKEEDFLSTFSQDRQANLAEHLEAALYGKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSEDFINFVHSCLQENASDRPRLESLLTYQLLLNPNKYLEQSHKKYEFSTIEVS 410

[Close]

BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000057661.1 (SMESG000057661.1)

HSP 1 Score: 160.229 bits (404), Expect = 1.239e-43
Identity = 110/320 (34.38%), Postives = 169/320 (52.81%), Query Frame = 1

Query:  577 NIKKRIGDVAF--EDIITLEELXXXXXXXXXXXXXXPSEQIMARKNIHLEIKPAIRTQIMRELQV-LHDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKA-----GRFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSF-VGTRSYMAPER----LTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPD-FCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFI 1494
            NI  +  D+ F  ED+  L E+G+G  G V ++ H+ ++Q+MA K I   +  + +   + +L V +   N P+IV +YG+   E +  ICME M   SLD   +        + PE I+  +    ++ L YL+  L +IHRDVKPSN+L++ +G++KLCDFG+SG+LIDS+A S   G + YMAPER    L+ + Y+  SDVWSLG+++ EL TG +P P                        A E                ++FE L+ ++   PP++ D   FS  F +FI  CL+K+ S R   + L++H F 
Sbjct:   39 NIPNKCSDLVFVSEDLQDLGEIGRGAYGSVNRMIHRKTDQLMAVKRIRSTLDESQQYSTLNDLDVIMKSANCPFIVRFYGALFREGDCWICMELM-STSLDKFYRYVYVHLKEKIPEKILGKVAVGTVKALDYLKVELRVIHRDVKPSNVLIDRDGNIKLCDFGISGQLIDSIAKSRDAGCKPYMAPERIHPKLSAKGYDIRSDVWSLGITMIELGTGKFPYP------------------------AWE----------------SVFEQLTCVLHGDPPSVNDSMGFSRQFQNFIERCLEKDYSKRPRYDELKQHPFF 317

[Close]

BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000007331.1 (SMESG000007331.1)

HSP 1 Score: 163.31 bits (412), Expect = 7.329e-43
Identity = 100/274 (36.50%), Postives = 150/274 (54.74%), Query Frame = 1

Query:  742 QIMRELQVL---HDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAG-RFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFV-GTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKS 1548
            +I R+L V+   HDC  P+IV  YG +   +E+ ICME M    LD +LK     FPE ++  ++C++++ L YL+    I+HRD+KPSN+L++  G+VKLCDFG+S +L DS+ANS   G   YMAPERL    Y+  +DVWSLG+SL ELA G +PI                            +G K +            FE+++ I+D  PP+LP+  +S  F  F++ CL+K+ ++R   + L    F    ++  L  +I R Y+S
Sbjct:  117 RIFRDLDVVTRCHDC--PFIVTCYGIFISPSEVWICMEEM-STCLDKLLKFLNCPFPEYVIGKVSCAIIKALQYLKTKHDIMHRDIKPSNMLLSDRGEVKLCDFGISAKLKDSIANSRQPGCIGYMAPERLNSSTYDVRADVWSLGMSLVELAIGKFPI----------------------------DGLKSE------------FEIMARIIDGKPPSLPEGVYSEAFNKFVSSCLQKDFNNRPKYDKLVSADFYRMHNVEPL--DILRWYRS 345

[Close]

BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000007331.1 (SMESG000007331.1)

HSP 1 Score: 163.31 bits (412), Expect = 7.534e-43
Identity = 100/274 (36.50%), Postives = 150/274 (54.74%), Query Frame = 1

Query:  742 QIMRELQVL---HDCNSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAG-RFPEPIVAHITCSVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMANSFV-GTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKFLSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPPPTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSEIKREYKS 1548
            +I R+L V+   HDC  P+IV  YG +   +E+ ICME M    LD +LK     FPE ++  ++C++++ L YL+    I+HRD+KPSN+L++  G+VKLCDFG+S +L DS+ANS   G   YMAPERL    Y+  +DVWSLG+SL ELA G +PI                            +G K +            FE+++ I+D  PP+LP+  +S  F  F++ CL+K+ ++R   + L    F    ++  L  +I R Y+S
Sbjct:  121 RIFRDLDVVTRCHDC--PFIVTCYGIFISPSEVWICMEEM-STCLDKLLKFLNCPFPEYVIGKVSCAIIKALQYLKTKHDIMHRDIKPSNMLLSDRGEVKLCDFGISAKLKDSIANSRQPGCIGYMAPERLNSSTYDVRADVWSLGMSLVELAIGKFPI----------------------------DGLKSE------------FEIMARIIDGKPPSLPEGVYSEAFNKFVSSCLQKDFNNRPKYDKLVSADFYRMHNVEPL--DILRWYRS 349

The following BLAST results are available for this feature:

BLAST of Protein kinase vs. Ensembl Human
BLAST of Protein kinase vs. Ensembl Celegans
BLAST of Protein kinase vs. Ensembl Fly
BLAST of Protein kinase vs. Ensembl Zebrafish
BLAST of Protein kinase vs. Ensembl Xenopus
BLAST of Protein kinase vs. Ensembl Mouse
BLAST of Protein kinase vs. UniProt/SwissProt
BLAST of Protein kinase vs. TrEMBL
BLAST of Protein kinase vs. Ensembl Cavefish
BLAST of Protein kinase vs. Ensembl Sea Lamprey
BLAST of Protein kinase vs. Ensembl Yeast
BLAST of Protein kinase vs. Ensembl Nematostella
BLAST of Protein kinase vs. Ensembl Medaka
BLAST of Protein kinase vs. Planmine SMEST

BLAST of Protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MAP2K2	4.816e-112	56.00	mitogen-activated protein kinase kinase 2 [Source:...	[more]
MAP2K1	2.724e-111	52.35	mitogen-activated protein kinase kinase 1 [Source:...	[more]
MAP2K2	5.016e-106	57.04	mitogen-activated protein kinase kinase 2 [Source:...	[more]
AC011005.1	8.089e-104	52.59	novel protein similar to mitogen-activated protein...	[more]
MAP2K5	3.638e-68	45.22	mitogen-activated protein kinase kinase 5 [Source:...	[more]

BLAST of Protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mek-2	2.429e-99	51.88	Dual specificity mitogen-activated protein kinase ...	[more]
sek-1	1.297e-43	35.67	Dual specificity mitogen-activated protein kinase ...	[more]
sek-1	1.297e-43	35.67	Dual specificity mitogen-activated protein kinase ...	[more]
jkk-1	3.052e-41	34.77	Dual specificity mitogen-activated protein kinase ...	[more]
gck-1	8.847e-38	35.05	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]

BLAST of Protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dsor1	8.945e-108	56.78	gene:FBgn0010269 transcript:FBtr0340120	[more]
Dsor1	9.134e-108	56.78	gene:FBgn0010269 transcript:FBtr0071313	[more]
lic	5.198e-43	35.94	gene:FBgn0261524 transcript:FBtr0073720	[more]
Mkk4	1.600e-42	38.03	gene:FBgn0024326 transcript:FBtr0334320	[more]
Mkk4	1.600e-42	38.03	gene:FBgn0024326 transcript:FBtr0081892	[more]

BLAST of Protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map2k2a	1.216e-109	56.39	mitogen-activated protein kinase kinase 2a [Source...	[more]
map2k2b	1.643e-109	58.04	mitogen-activated protein kinase kinase 2b [Source...	[more]
map2k2b	1.643e-109	58.04	mitogen-activated protein kinase kinase 2b [Source...	[more]
map2k1	4.442e-106	55.11	mitogen-activated protein kinase kinase 1 [Source:...	[more]
map2k5	1.132e-65	43.75	mitogen-activated protein kinase kinase 5 [Source:...	[more]

BLAST of Protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pik3cb	1.338e-110	55.11	phosphatidylinositol-4,5-bisphosphate 3-kinase cat...	[more]
pik3cb	2.052e-110	55.11	phosphatidylinositol-4,5-bisphosphate 3-kinase cat...	[more]
pik3cb	5.807e-105	55.37	phosphatidylinositol-4,5-bisphosphate 3-kinase cat...	[more]
pik3cb	1.284e-103	55.81	phosphatidylinositol-4,5-bisphosphate 3-kinase cat...	[more]
map2k5	2.278e-66	45.05	mitogen-activated protein kinase kinase 5 [Source:...	[more]

BLAST of Protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Map2k1	1.732e-112	52.63	mitogen-activated protein kinase kinase 1 [Source:...	[more]
Map2k2	5.791e-111	55.45	mitogen-activated protein kinase kinase 2 [Source:...	[more]
Map2k2	9.602e-111	55.28	mitogen-activated protein kinase kinase 2 [Source:...	[more]
Map2k5	1.650e-67	45.05	mitogen-activated protein kinase kinase 5 [Source:...	[more]
Map2k3	4.229e-46	36.39	mitogen-activated protein kinase kinase 3 [Source:...	[more]

BLAST of Protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P31938\|MP2K1_MOUSE	1.211e-111	52.63	Dual specificity mitogen-activated protein kinase ...	[more]
sp\|P36507\|MP2K2_HUMAN	2.313e-111	56.00	Dual specificity mitogen-activated protein kinase ...	[more]
sp\|Q91447\|MP2K1_SERCA	3.591e-111	55.73	Dual specificity mitogen-activated protein kinase ...	[more]
sp\|P29678\|MP2K1_RABIT	1.125e-110	52.35	Dual specificity mitogen-activated protein kinase ...	[more]
sp\|Q02750\|MP2K1_HUMAN	1.308e-110	52.35	Dual specificity mitogen-activated protein kinase ...	[more]

BLAST of Protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A193PD23	0.000e+0	80.04	MAPK/ERK kinase 1/2 OS=Dugesia japonica OX=6161 PE...	[more]
A0A430QH14	1.983e-139	61.62	Mitogen-activated protein kinase kinase 1 OS=Schis...	[more]
A0A094ZYV9	2.787e-139	63.61	Protein kinase domain-containing protein (Fragment...	[more]
A0A3Q0KDI9	4.664e-139	61.62	Protein kinase OS=Schistosoma mansoni OX=6183 PE=4...	[more]
G4VT52	2.658e-138	63.42	Protein kinase OS=Schistosoma mansoni OX=6183 GN=S...	[more]

BLAST of Protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map2k2b	1.147e-111	58.04	mitogen-activated protein kinase kinase 2 [Source:...	[more]
map2k1	5.929e-107	54.80	mitogen-activated protein kinase kinase 1 [Source:...	[more]
map2k5	2.605e-62	39.47	mitogen-activated protein kinase kinase 5 [Source:...	[more]
map2k5	2.576e-60	38.70	mitogen-activated protein kinase kinase 5 [Source:...	[more]
map2k5	5.956e-60	40.51	mitogen-activated protein kinase kinase 5 [Source:...	[more]

BLAST of Protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000004725.1	5.196e-108	57.33	pep scaffold:Pmarinus_7.0:GL477683:141377:157028:-...	[more]
map2k4b	1.911e-45	36.89	mitogen-activated protein kinase kinase 4b [Source...	[more]
map2k6	1.552e-43	34.19	mitogen-activated protein kinase kinase 6 [Source:...	[more]
map2k7	2.037e-41	33.05	mitogen-activated protein kinase kinase 7 [Source:...	[more]
stk25a	2.202e-39	35.76	serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G...	[more]

BLAST of Protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
PBS2	2.072e-61	42.67	MAP kinase kinase of the HOG signaling pathway; ac...	[more]
MKK2	9.541e-52	40.00	MAPKK involved in the protein kinase C signaling p...	[more]
MKK1	1.966e-50	40.00	MAPKK involved in the protein kinase C signaling p...	[more]
STE7	1.604e-48	37.11	Signal transducing MAP kinase kinase; involved in ...	[more]
KIC1	3.208e-29	32.82	Protein kinase of the PAK/Ste20 family, required f...	[more]

BLAST of Protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO45553	2.018e-115	58.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40740	1.514e-68	43.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48408	1.667e-42	33.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38062	1.814e-42	34.30	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31934	3.359e-40	36.64	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map2k2a	4.148e-110	57.05	mitogen-activated protein kinase kinase 2 [Source:...	[more]
map2k1	1.281e-107	55.28	mitogen-activated protein kinase kinase 1 [Source:...	[more]
map2k5	3.324e-65	40.64	mitogen-activated protein kinase kinase 5 [Source:...	[more]
map2k5	8.301e-65	40.64	mitogen-activated protein kinase kinase 5 [Source:...	[more]
map2k5	4.371e-61	41.57	mitogen-activated protein kinase kinase 5 [Source:...	[more]

BLAST of Protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000004166.1	0.000e+0	99.79	SMESG000004166.1	[more]
SMESG000040086.1	1.774e-136	61.72	SMESG000040086.1	[more]
SMESG000057661.1	1.239e-43	34.38	SMESG000057661.1	[more]
SMESG000007331.1	7.329e-43	36.50	SMESG000007331.1	[more]
SMESG000007331.1	7.534e-43	36.50	SMESG000007331.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033533 ID=SMED30033533|Name=Protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1855bp
TATTGGTTATATAATTAAACTTATTGTGGTGTCTATAATTTGTGAAATGT
GTTCCTATATATATCTATAGCTGTTGATTATATTTTGCATCAAATTTAAG
TGCTAGAATTGATTGTAACTTTTTCAGGTTTAGATTGGCTACACAGGATC
AGTTTTTCTTAAAATTTTTTTTCATAAATGAGCCAAAGAAGTCCGAAAAA
CCATTTAAATCTAATGCTGCCCAGTAAAGATACTTGTAAAGGAATTGAGA
TATCTGAAACAGCGTCGAATAATATTCGAAATAAAGAAAGTCCTAAATCG
GATAGTCACGAATCTAATAATTTTGAAATACCATCTATCGTGCAAGATGT
TTTTCCGAGATCCGATGCCATTGAAACTGATTGTGCTCAGTCAAATGAAT
GTTTAACGGAATTAATTAATAATGTTTATTTAACTCCAATATCTGCCTCG
TCTAGCATATACTTGAATCGACCCGTCAGTGATTGTACAAATAGAAATTC
AAATTATTCAGAAAATGTCGCAACAAATATTCACGAAATCACTGTTCAGC
AGAAACAAATCCTTTTGAATTTTCAAAATATTAAAAAAAGAATAGGCGAT
GTTGCTTTTGAAGATATAATCACTTTGGAGGAATTAGGGAAAGGAAATGG
TGGAGTAGTAGCCAAAGTTAAGCATAAGCCATCTGAGCAGATTATGGCTA
GGAAAAATATCCATTTGGAAATCAAGCCAGCGATTCGCACCCAAATCATG
AGAGAACTACAGGTTCTTCATGACTGTAATTCACCCTATATTGTTGGATA
CTATGGATCATATCATGTTGAAACAGAAATATCAATATGTATGGAATATA
TGGATGGTGGTAGTCTCGACTTGATTCTTAAAAAAGCTGGACGTTTTCCA
GAACCTATCGTTGCTCACATAACATGCTCGGTTTTACGTGGACTTATATA
TTTAAGAAAAGCATTACATATTATTCACAGAGATGTCAAACCTTCAAATA
TTTTAGTAAACATGGAAGGAGATGTTAAATTATGTGATTTCGGTGTAAGT
GGAAGATTAATTGACTCAATGGCAAATTCTTTTGTTGGTACTAGATCCTA
TATGGCACCAGAACGGCTTACAGGCGAGCAATATAACACTCTCAGTGATG
TATGGAGTCTCGGTTTGTCATTGGCAGAATTAGCAACCGGTATTTATCCG
ATTCCTCCTGTGGGACCGGAAAAATTTCTATCAGCTTTTTCAATTCATAA
AAATGAGAACTTTATTGACCATCTAATGGCTACTGAAAACGGAACAAAGT
TGCAAGCGATTCAAGCCTCAGAAAAAGGACCCATGGCGATATTCGAATTG
CTCTCTTATATTGTCGACTATCCGCCACCGACATTGCCGGATTTCTGTTT
TTCATCGAATTTTTTGTCGTTCATTAATTATTGCTTGAAAAAAGAACCTA
GTGACCGCTTGAGCTTGGAAATGTTGGAGAAACACAAATTCATTGCCGCG
GACTCTATTGCGATATTAACATCAGAGATTAAACGAGAATATAAATCGAC
AAGCAAATCACACGAATTGTTTGTCGGTCAATATGTGCAAAAGATTATGT
TATTGTAGAAAATGCATCAGAATATTTTTTTCAATGAACAAATTTTGAAT
CCTTTATCGATAAGATCTTGAGTTCTTGTATTTCTCGATATTTTCAGAAA
ATGAAAAATTACAAAATATCATTTTTTCTCTTAAAAATTTTAATTTTTCG
CCACAAAACTTTCAGCGATACGAAAAATTCTGATCAGTAAATATACTGAT
GACGTTAAAGGTAAAAATTTCGAACTCTAGCGGTAAAAAAAATTTTACTT
TATAA

protein sequence of SMED30033533-orf-1

>SMED30033533-orf-1 ID=SMED30033533-orf-1|Name=SMED30033533-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=477bp
MSQRSPKNHLNLMLPSKDTCKGIEISETASNNIRNKESPKSDSHESNNFE
IPSIVQDVFPRSDAIETDCAQSNECLTELINNVYLTPISASSSIYLNRPV
SDCTNRNSNYSENVATNIHEITVQQKQILLNFQNIKKRIGDVAFEDIITL
EELGKGNGGVVAKVKHKPSEQIMARKNIHLEIKPAIRTQIMRELQVLHDC
NSPYIVGYYGSYHVETEISICMEYMDGGSLDLILKKAGRFPEPIVAHITC
SVLRGLIYLRKALHIIHRDVKPSNILVNMEGDVKLCDFGVSGRLIDSMAN
SFVGTRSYMAPERLTGEQYNTLSDVWSLGLSLAELATGIYPIPPVGPEKF
LSAFSIHKNENFIDHLMATENGTKLQAIQASEKGPMAIFELLSYIVDYPP
PTLPDFCFSSNFLSFINYCLKKEPSDRLSLEMLEKHKFIAADSIAILTSE
IKREYKSTSKSHELFVGQYVQKIMLL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000074	oocyte
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal
PLANA:0000231	vitelline gland

Vocabulary: **INTERPRO**
Term	Definition
IPR000719	Prot_kinase_dom
IPR008271	Ser/Thr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0043539	protein serine/threonine kinase activator activity
GO:0047485	protein N-terminus binding

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0000187	activation of MAPK activity
GO:0001932	regulation of protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021697	cerebellar cortex formation
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0030878	thyroid gland development
GO:0032872	regulation of stress-activated MAPK cascade
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048538	thymus development
GO:0048679	regulation of axon regeneration
GO:0048870	cell motility
GO:0050772	positive regulation of axonogenesis
GO:0060020	Bergmann glial cell differentiation
GO:0060324	face development
GO:0060425	lung morphogenesis
GO:0060440	trachea formation
GO:0060502	epithelial cell proliferation involved in lung morphogenesis
GO:0060674	placenta blood vessel development
GO:0060711	labyrinthine layer development
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090170	regulation of Golgi inheritance
GO:0090398	cellular senescence
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641	regulation of early endosome to late endosome transport

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0070062	extracellular exosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 147..439 e-value: 5.4E-77 score: 271.8
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 150..439 e-value: 3.9E-61 score: 206.7
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 147..439 score: 42.534
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 227..463 e-value: 5.9E-60 score: 204.7
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 116..226 e-value: 1.6E-38 score: 133.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 27..49
None	No IPR available	PANTHER	PTHR47448	FAMILY NOT NAMED	coord: 98..440
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 265..277
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 153..176
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 139..442