Calcium activated potassium channel subunit
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033475 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Calcium activated potassium channel subunit vs. TrEMBL
Match: A0A1I8G080 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 137.887 bits (346), Expect = 4.734e-36 Identity = 78/217 (35.94%), Postives = 121/217 (55.76%), Query Frame = 2 Query: 227 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKH---KVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFY----KDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 M ++ D++CN +G++K+ +LA TL T G+I+ IL+ L+++PY E ++ + C Y I K+ CE+KC+K+ S F C I+VS + + G L++N TFS+ +++C T PCL +N F +L + F C Y K T VLL+++ S +CI+WP + GL L T+YCAGC +W+QDKTVIA Sbjct: 1 MALKRCDRLCNVHGLAKLIFLACITLITCGVIVGTILVPLIILPYSRESRFADANCTYLTEHLIAKL---PCESKCSKDKSSFPCYSIRVSISQTNQT----GMLYENFITFSERHDEPINQCGTAPCLSQAAENVAMTTRFIRTLRKSRSFPCHYQPASKPGGPTPVLLHRIFSRRQATHCIIWPAVAVAAGLSLLVSTYYCAGCTVWTQDKTVIA 210
BLAST of Calcium activated potassium channel subunit vs. TrEMBL
Match: A0A1I8G034 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 135.576 bits (340), Expect = 3.722e-35 Identity = 78/217 (35.94%), Postives = 121/217 (55.76%), Query Frame = 2 Query: 227 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKH---KVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFY----KDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 M ++ D++CN +G++K+ +LA TL T G+I+ IL+ L+++PY E ++ + C Y I K+ CE+KC+K+ S F C I+VS + + G L++N TFS+ +++C T PCL +N F +L + F C Y K T VLL+++ S +CI+WP + GL L T+YCAGC +W+QDKTVIA Sbjct: 1 MALKRCDRLCNVHGLAKLIFLACITLITCGVIVGTILVPLIILPYSRESRFADANCTYLTEHLIAKL---PCESKCSKDKSSFPCYSIRVSISQTNQT----GMLYENFITFSERHDEPINQCGTAPCLSQAAENVAMTTRFIRTLRKSRSFPCHYQPASKPGGPTPVLLHRIFSRRQATHCIIWPAVAVAAGLALLVSTYYCAGCTVWTQDKTVIA 210
BLAST of Calcium activated potassium channel subunit vs. TrEMBL
Match: A0A1I8GE69 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 126.331 bits (316), Expect = 1.304e-31 Identity = 71/213 (33.33%), Postives = 121/213 (56.81%), Query Frame = 2 Query: 227 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDET---TNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 M ++ ++CN GI+K +L +L T G+I+ IL YL+++PY E ++ T+C Y G ++ ++I CE+KC K+ S + C ++V+ + + G LF+N T+ + CS+ PCL +N + ++L RR F C+++ ++ +VLL K+ + +C +WP +++G I L T YCAGC +W+QDKTVIA Sbjct: 1 MALRRCHRLCNVMGIAKYVFLTCVSLITCGVIVGGILAYLIILPYYREARFEQTSCVYL-GEEMKRII--DCESKCAKDRSSYPCYMVRVNISGVPEQ----GVLFENFLTYLEQDKTNCSSAPCLPEAVENVEMTRRYIKTLRRRRNFTCYFRGPDSRQKNSVLLTKIYTKEQAKHCAIWPAFAVSIGAIVLIGTHYCAGCTVWTQDKTVIA 206
BLAST of Calcium activated potassium channel subunit vs. TrEMBL
Match: A0A1I8HKS0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 126.331 bits (316), Expect = 1.450e-31 Identity = 71/213 (33.33%), Postives = 121/213 (56.81%), Query Frame = 2 Query: 227 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDET---TNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 M ++ ++CN GI+K +L +L T G+I+ IL YL+++PY E ++ T+C Y G ++ ++I CE+KC K+ S + C ++V+ + + G LF+N T+ + CS+ PCL +N + ++L RR F C+++ ++ +VLL K+ + +C +WP +++G I L T YCAGC +W+QDKTVIA Sbjct: 1 MALRRCHRLCNVIGIAKYVFLTCVSLITCGVIVGGILAYLIILPYYREARFEQTSCVYL-GEEMKRII--DCESKCAKDRSSYPCYMVRVNISGVPEQ----GVLFENFLTYLEQDKTNCSSAPCLPEAVENVEMTRRYIKTLRRRRNFTCYFRGPDSRQKNSVLLTKIYTKEQAKHCAIWPAFAVSIGAIVLIGTHYCAGCTVWTQDKTVIA 206
BLAST of Calcium activated potassium channel subunit vs. TrEMBL
Match: A0A4S2LYB8 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_004041 PE=4 SV=1) HSP 1 Score: 127.102 bits (318), Expect = 1.632e-31 Identity = 77/194 (39.69%), Postives = 106/194 (54.64%), Query Frame = 2 Query: 275 KVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 K+TYL AT+ T LIIECILL LVV+PYL E + T C Y GS+I + +K CENKC+K+ S F C+ + V+Y K + Q LFDN+ T+ + C+T C E NR F++ + R F CF +D LL+K P + N + WP TLL + + L + W C+ W + TVIA Sbjct: 55 KITYLTCATVITTSLIIECILLRLVVMPYLHESGFSATRCVYI-GSRIIQNAVK-CENKCSKDRSTFQCIRVMVAYAK--NNQNYTANLFDNIATYQHYHTLGCATSSCQRRNEANRASVEEFHQLIRRSARFDCFTHEDHVNEALLHKFYGPATLFNTLFWPLTLLVISSLVLMVVWIYDRCRAWGDENTVIA 244
BLAST of Calcium activated potassium channel subunit vs. Planmine SMEST
Match: SMESG000032303.1 (SMESG000032303.1) HSP 1 Score: 404.06 bits (1037), Expect = 4.443e-144 Identity = 210/210 (100.00%), Postives = 210/210 (100.00%), Query Frame = 2 Query: 227 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCTLLTLGLISLFLTWYCAGCKIWSQDKTVIA Sbjct: 1 MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCTLLTLGLISLFLTWYCAGCKIWSQDKTVIA 210
BLAST of Calcium activated potassium channel subunit vs. Planmine SMEST
Match: SMESG000053268.1 (SMESG000053268.1) HSP 1 Score: 162.925 bits (411), Expect = 3.636e-49 Identity = 89/208 (42.79%), Postives = 134/208 (64.42%), Query Frame = 2 Query: 254 CNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILK-----KCENKCTKETSFFYCLFIKVSYKKIHS--KQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 CN GISK+ YL+S T T+G I+ECILL+L++ PYL+EQ++ TTC Y S + IL +CENKCTK+T F C+++ V+Y +S +QL GYL+D RT++++K +CST PC LL DN W ++F+ +LY + F C+Y + +VLLYKL +++++CI+WP + +GL+ + T AGC +W + VIA Sbjct: 13 CNETGISKLIYLSSMTFLTSGFILECILLHLMLTPYLAEQEFEQTTCVYRNSS--SRFILLSDLQLRCENKCTKDTGKFPCVWLLVNYVIPNSGQRQLQDGYLYDYYRTYNRYKKQRCSTSPCHLLLSDNIDWVISFDRTLYSKHNFSCYYNTKDHMSVLLYKLYPKSLILHCILWPFGIFIVGLVGITFTALIAGCDVWKNEDVVIA 218
BLAST of Calcium activated potassium channel subunit vs. Planmine SMEST
Match: SMESG000017226.1 (SMESG000017226.1) HSP 1 Score: 119.398 bits (298), Expect = 3.518e-32 Identity = 65/194 (33.51%), Postives = 109/194 (56.19%), Query Frame = 2 Query: 275 KVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 K+ YLAS ++F + I+ CIL++LV+IPYL E +I+ C+ E +++G + +CENKC+K+ S F CL I V+Y++ + ++ YL++++ T + C+T PC DN FN + R+ F CF + LLYK + ++C +WP L+ SL + + C++W D+TVI+ Sbjct: 40 KIIYLASISIFVSTFIVVCILMHLVIIPYLHETSFISAQCNLNE-TRMGDEV--RCENKCSKDRSKFKCLQIIVNYRR--NNKMFSAYLYEHVATLRHFSKNHCATSPCHKEEIDNYLIVSRFNRDIKRQRNFNCFTSIKHPSEALLYKFYDASTFLHCTLWPLLLIVSSATSLTVIYQIDKCRVWHDDRTVIS 228
BLAST of Calcium activated potassium channel subunit vs. Planmine SMEST
Match: SMESG000055809.1 (SMESG000055809.1) HSP 1 Score: 105.145 bits (261), Expect = 6.365e-27 Identity = 69/208 (33.17%), Postives = 109/208 (52.40%), Query Frame = 2 Query: 263 YGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYK------KIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDN----RRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQDKTVIA 856 + + K Y++S ++ +G IIECILL+L++ PY E ++++ C S + KC NKC+KE S F+C +KV Y+ ++ ++ GYLFD + T K +KC PC L DN R + + L + F C+ T VLLYK S ++CI+WP TL+ L + + L ++ CK+W+ DK +I Sbjct: 10 HSVLKFLYISSLSVAVSGFIIECILLHLIISPYGHETQFVDGKCTVLNISTRYGI---KCVNKCSKERSKFFCSTVKVKYQSKISLGRLSNQTWYHGYLFDQITTLHNFKDEKCIISPCYKLKLDNYIETRNFLHVHFDHLESNSAFPCYVNRYLTNEVLLYKFYSYETYISCILWPITLIVLSVFIILLCYWIDRCKVWANDKAIIT 214
BLAST of Calcium activated potassium channel subunit vs. Planmine SMEST
Match: SMESG000047387.1 (SMESG000047387.1) HSP 1 Score: 93.5893 bits (231), Expect = 7.255e-23 Identity = 57/188 (30.32%), Postives = 95/188 (50.53%), Query Frame = 2 Query: 275 KVTYLASATLFTAGLIIECILLYLVVIPYLSEQKYINTTCHYTEGSKIGKMILKKCENKCTKETSFFYCLFIKVSYKKIHSKQLTIGYLFDNLRTFSKHKVDKCSTMPCLGLLEDNRRWAMAFNESLYRRTYFQCFYKDDETTNVLLYKLQSPTIVMNCIVWPCXXXXXXXXXXXXXWYCAGCKIWSQ 838 K Y++ +TL LI+ IL++LVVIP+ E + ++TC + + KCENKC+K+ S F CL I Y + Q + Y++D++ T S ++ +C+ PC +DN F + + F C+ + VLLYK S + +C+ WP LL + L+ L + + C +W+ Sbjct: 14 KFLYISCSTLSLCALIVGAILIHLVVIPFTHENSFYSSTCTLINTNITTSI---KCENKCSKDRSMFPCLQITAKYTDL--DQEFLAYVYDHIATLSHYRKSQCAISPCFSSTKDNGIIVSEFQSRMRKTPTFACYINAEHRDEVLLYKFYSIGMFWHCVAWPSGLLVISLLILAVLYSKDKCNVWND 196 The following BLAST results are available for this feature:
BLAST of Calcium activated potassium channel subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Calcium activated potassium channel subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Calcium activated potassium channel subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033475 ID=SMED30033475|Name=Calcium activated potassium channel subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=884bpback to top protein sequence of SMED30033475-orf-1 >SMED30033475-orf-1 ID=SMED30033475-orf-1|Name=SMED30033475-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=211bp MTVQALDKICNYYGISKVTYLASATLFTAGLIIECILLYLVVIPYLSEQKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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